has_part
gene_ontology
BFO:0000051
http://purl.org/obo/owl/BFO#BFO_0000051
OBO_REL:has_part
http://purl.org/obo/owl/OBO_REL#OBO_REL_has_part
part_of
gene_ontology
BFO:0000050
http://purl.org/obo/owl/BFO#BFO_0000050
OBO_REL:part_of
http://purl.org/obo/owl/OBO_REL#OBO_REL_part_of
adjacent_to
in spatial proximity to, but not overlapping
RO:overlaps
http://purl.org/obo/owl/RO#RO_overlaps
attaches_to
boundary_part_of
X boundary_part_of Y if (1) X part_of Y and (2) all parts of Y that are adjacent_to the exterior are parts of X. For example, between a membrane and the organelle it is part of
bounded_by
does NOT imply part of (a boundary is ny necessity between two things). E.g. GO:0030287 cell wall-bounded periplasmic space. x and y are externally connected and the whole of the external boundary of x is in contact with y. (ie holes don't count)
bounds
completely_bounded_by
TODO - change many of the existing bounded_by relations to this
x and y are externally connected and the whole boundary of x is in contact with y.
complex_of
Example: polysome complex_of ribosome
X complex_of Y all instance of X has_part y1 and has_part y2 where y1 and y2 are distinct instances of Y
continuous_with
shares fiat boundary with
enclosed_by
similar to bounded_by but not necessarily adjacent.
extrinsic_to
has_part
inner_part_of
lacks_part
lumen_of
placeholder relation until the relevant membrane term has been declared. X lumen_of Y if X is a lumen and there exists some membrane Z such that X bounded_by Z and Z boundary_part_of Y.
negatively_regulates
gene_ontology
RO:0002212
http://purl.org/obo/owl/RO#RO_0002212
occurs in
gene_ontology
BFO:0000066
http://purl.org/obo/owl/BFO#BFO_0000066
outer_part_of
overlaps
x overlaps y if there is some region that is part of both x and y
partially_enclosed_by
a cross-section of x is lumen_of y. i.e. x is an invagination within y
perforates
x perforates y if x is part of y and x surrounds a space that is adjacent_to the inside and outside of y
positively_regulates
gene_ontology
RO:0002213
http://purl.org/obo/owl/RO#RO_0002213
reachable_over_adjacent_to
regulates
gene_ontology
RO:0002211
http://purl.org/obo/owl/RO#RO_0002211
results_in
This relation is currently used to connect two regulation processes p1 and p2, such that if r1 regulates p1 and r2 regulates p2, and r1 results_in r2 then the regulation of p1 is required for the regulation of p2. For an example of use, see GO:0035958 'regulation of glyoxylate cycle by regulation of transcription from RNA polymerase II promoter'. Note that a precise definition of this relation is under discussion. After it has been formalized it will be added to RO, where it will have a RO ID. Note that the existing identifier and label are subject to change.
gene_ontology
spans
A spans B iff A overlaps B and A overlaps the two regions on either side of B
phosphopyruvate hydratase complex
cellular_component
A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
enolase complex
repairosome
This term was made obsolete because 'repairosome' has fallen out of use in the literature, and the large complex described in the definition has not been confirmed to exist. The term has also confused annotators.
cellular_component
OBSOLETE. A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage.
PMID:9852079
http://purl.org/obo/owl/PMID#PMID_9852079
PMID:10681587
http://purl.org/obo/owl/PMID#PMID_10681587
nucleotide-excision repair complex
Note that process information is included in the term and definition for the purpose of describing and distinguishing the complex.
cellular_component
Any complex formed of proteins that act in nucleotide-excision repair.
PMID:10915862
http://purl.org/obo/owl/PMID#PMID_10915862
nucleotide-excision repair factor 1 complex
Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
cellular_component
One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively.
PMID:10915862
http://purl.org/obo/owl/PMID#PMID_10915862
XPA-ERCC1-ERCC4 complex
PMID:8197175
http://purl.org/obo/owl/PMID#PMID_8197175
NEF1 complex
nucleotide-excision repair factor 2 complex
Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
cellular_component
NEF2 complex
One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p.
PMID:10915862
http://purl.org/obo/owl/PMID#PMID_10915862
nucleotide-excision repair factor 3 complex
Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
cellular_component
One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (Core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. Note that Ssl2p is also called Rad25p).
PMID:7813015
http://purl.org/obo/owl/PMID#PMID_7813015
PMID:14500720
http://purl.org/obo/owl/PMID#PMID_14500720
PMID:10915862
http://purl.org/obo/owl/PMID#PMID_10915862
NEF3 complex
nucleotide-excision repair factor 4 complex
Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
cellular_component
NEF4 complex
One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p.
PMID:10915862
http://purl.org/obo/owl/PMID#PMID_10915862
histone deacetylase complex
Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone deacetylase activity ; GO:0004407'.
cellular_component
A protein complex that possesses histone deacetylase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
HDAC complex
RNA polymerase I transcription factor complex
cellular_component
A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase I.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
histone acetyltransferase complex
Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone acetyltransferase activity ; GO:0004402'.
cellular_component
A protein complex that possesses histone acetyltransferase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
histone acetylase complex
SAGA complex
cellular_component
Spt-Ada-Gcn5-acetyltransferase complex
A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery.
PMID:10637607
http://purl.org/obo/owl/PMID#PMID_10637607
PMID:17337012
http://purl.org/obo/owl/PMID#PMID_17337012
PCAF complex
See also the cellular component term 'SAGA complex ; GO:0000124'.
cellular_component
A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs.
PMID:10637607
http://purl.org/obo/owl/PMID#PMID_10637607
SPT3-TAF9-PCAF acetylase complex
PMID:18838386
http://purl.org/obo/owl/PMID#PMID_18838386
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
PCAF histone acetylase-associated complex
transcription factor TFIIIB complex
cellular_component
A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF.
PMID:11433012
http://purl.org/obo/owl/PMID#PMID_11433012
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
transcription factor TFIIIC complex
cellular_component
A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions.
PMID:11433012
http://purl.org/obo/owl/PMID#PMID_11433012
PMID:16751097
http://purl.org/obo/owl/PMID#PMID_16751097
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
incipient cellular bud site
cellular_component
The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence.
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
polarisome
cellular_component
Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p.
PMID:14998522
http://purl.org/obo/owl/PMID#PMID_14998522
PMID:9632790
http://purl.org/obo/owl/PMID#PMID_9632790
PMID:14734532
http://purl.org/obo/owl/PMID#PMID_14734532
alpha-1,6-mannosyltransferase complex
cellular_component
A large, multiprotein complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins.
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
PMID:10037752
http://purl.org/obo/owl/PMID#PMID_10037752
PMID:11095735
http://purl.org/obo/owl/PMID#PMID_11095735
PMID:18083825
http://purl.org/obo/owl/PMID#PMID_18083825
Golgi cis cisterna
cellular_component
The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
Golgi trans cisterna
cellular_component
late Golgi
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
Golgi membrane
cellular_component
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cellular bud neck contractile ring
cellular_component
neck ring
A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae.
PMID:16009555
http://purl.org/obo/owl/PMID#PMID_16009555
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
cellular bud neck septin ring
cellular_component
A ring-shaped structure that forms at the site of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange.
PMID:16009555
http://purl.org/obo/owl/PMID#PMID_16009555
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
exocyst
cellular_component
A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.
PMID:9700152
http://purl.org/obo/owl/PMID#PMID_9700152
Sec6/8 complex
Wikipedia:Exocyst
http://purl.org/obo/owl/Wikipedia#Wikipedia_Exocyst
1,3-beta-D-glucan synthase complex
cellular_component
(1->3)-beta-glucan synthase complex
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
1,3-beta-glucan synthase complex
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain.
EC:2.4.1.34
http://purl.org/obo/owl/EC#EC_2.4.1.34
ubiquitin ligase complex
cellular_component
A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex.
PMID:9529603
http://purl.org/obo/owl/PMID#PMID_9529603
nuclear ubiquitin ligase complex
cellular_component
A ubiquitin ligase complex found in the nucleus.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cytoplasmic ubiquitin ligase complex
cellular_component
A ubiquitin ligase complex found in the cytoplasm.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
protein phosphatase type 2A complex
cellular_component
A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:17245430
http://purl.org/obo/owl/PMID#PMID_17245430
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
protein phosphatase type 1 complex
cellular_component
A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:ssd
http://purl.org/obo/owl/GOC#GOC_ssd
ribonuclease MRP complex
cellular_component
A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication.
PMID:7510714
http://purl.org/obo/owl/PMID#PMID_7510714
PMID:10690410
http://purl.org/obo/owl/PMID#PMID_10690410
PMID:14729943
http://purl.org/obo/owl/PMID#PMID_14729943
GOC:sgd_curators
http://purl.org/obo/owl/GOC#GOC_sgd_curators
ribonuclease mitochondrial RNA processing complex
RNase MRP complex
nuclear exosome (RNase complex)
cellular_component
Complex of 3'-5' exoribonucleases found in the nucleus.
PMID:10465791
http://purl.org/obo/owl/PMID#PMID_10465791
eukaryotic exosome multienzyme ribonuclease complex
nuclear exosome (ribonuclease complex)
nuclear exosome multienzyme ribonuclease complex
cytoplasmic exosome (RNase complex)
cellular_component
prokaryotic exosome multienzyme ribonuclease complex
cytoplasmic exosome multienzyme ribonuclease complex
cytoplasmic exosome (ribonuclease complex)
Complex of 3'-5' exoribonucleases found in the cytoplasm.
PMID:10465791
http://purl.org/obo/owl/PMID#PMID_10465791
exosome (RNase complex)
Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies.
cellular_component
exosome (ribonucleasease complex)
Complex of 3'-5' exoribonucleases.
PMID:10465791
http://purl.org/obo/owl/PMID#PMID_10465791
exosome multienzyme ribonuclease complex
cytosolic large ribosomal subunit
This term was made obsolete because more specific children exist.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
cytosolic small ribosomal subunit
This term was made obsolete because more specific children exist.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
tRNA-intron endonuclease complex
cellular_component
SEN complex
PMID:22391451
http://purl.org/obo/owl/PMID#PMID_22391451
GOC:se
http://purl.org/obo/owl/GOC#GOC_se
A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.
EC:3.1.27.9
http://purl.org/obo/owl/EC#EC_3.1.27.9
tRNA splicing endonuclease complex
PMID:22391451
http://purl.org/obo/owl/PMID#PMID_22391451
GOC:se
http://purl.org/obo/owl/GOC#GOC_se
vacuolar hydrogen-transporting ATPase
This term was made obsolete because more specific terms were created.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
V-ATPase
vacuolar proton-transporting V-type ATPase, V0 domain
Note that this domain often consists of five subunits, although in some mammalian tissues it may have an additional subunit.
cellular_component
The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:16449553
http://purl.org/obo/owl/PMID#PMID_16449553
vacuolar hydrogen ion-transporting ATPase V0 domain
vacuolar proton-transporting V-type ATPase, V1 domain
Note that this domain generally consists of eight subunits.
cellular_component
vacuolar hydrogen ion-transporting ATPase V1 domain
The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.
PMID:16449553
http://purl.org/obo/owl/PMID#PMID_16449553
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
plasma membrane proton-transporting V-type ATPase, V0 domain
cellular_component
The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
plasma membrane hydrogen ion-transporting ATPase V0 domain
plasma membrane proton-transporting V-type ATPase, V1 domain
cellular_component
The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
plasma membrane hydrogen ion-transporting ATPase V1 domain
nuclear chromosome
cellular_component
A chromosome found in the nucleus of a eukaryotic cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
nuclear interphase chromosome
cytoplasmic chromosome
cellular_component
A chromosome found in the cytoplasm.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cytoplasmic interphase chromosome
nuclear mitotic chromosome
This term was made obsolete because it is based on a temporal division of the cell cycle.
cellular_component
OBSOLETE. A chromosome found in the nucleus during mitosis.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cytoplasmic mitotic chromosome
This term was made obsolete because it is based on a temporal division of the cell cycle.
cellular_component
OBSOLETE. A chromosome found in the cytoplasm during mitosis.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
nuclear interphase chromosome
This term was made obsolete because it is based on a temporal division of the cell cycle.
cellular_component
OBSOLETE. A chromosome found in the nucleus during interphase.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cytoplasmic interphase chromosome
This term was made obsolete because it is based on a temporal division of the cell cycle.
cellular_component
OBSOLETE. A chromosome found in the cytoplasm during interphase.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
astral microtubule
cellular_component
Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
pericentriolar material
cellular_component
A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
commitment complex
cellular_component
A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript.
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
PMID:9150140
http://purl.org/obo/owl/PMID#PMID_9150140
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
mammalian spliceosomal complex E
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
mammalian spliceosomal E complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
yeast spliceosomal complex CC
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
mitochondrial chromosome
cellular_component
NIF_Subcellular:sao1186327184
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1186327184
mtDNA
A chromosome found in the mitochondrion of a eukaryotic cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mitochondrial DNA
mitochondrial genome
cell fraction
Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. It is advised that this term should only be used in a manual annotation statement where it is possible to apply an experimental evidence code and only if no other experimental evidence exists for an equivalent in vivo subcellular location.
cellular_component
A generic term for parts of cells prepared by disruptive biochemical techniques.
GOC:ma
http://purl.org/obo/owl/GOC#GOC_ma
mitochondrial proton-transporting ATP synthase, stator stalk
cellular_component
One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core.
PMID:10838056
http://purl.org/obo/owl/PMID#PMID_10838056
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
cellular_component
The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:10838056
http://purl.org/obo/owl/PMID#PMID_10838056
proton-transporting ATP synthase complex, catalytic core F(1)
hydrogen-transporting ATP synthase, F1 sector
mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
cellular_component
All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins.
PMID:10838056
http://purl.org/obo/owl/PMID#PMID_10838056
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
integral to membrane of membrane fraction
Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. It is advised that this term should only be used in a manual annotation statement where it is possible to apply an experimental evidence code and only if no other experimental evidence exists for an equivalent in vivo subcellular location.
cellular_component
Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes.
PMID:10512869
http://purl.org/obo/owl/PMID#PMID_10512869
peripheral to membrane of membrane fraction
Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. It is advised that this term should only be used in a manual annotation statement where it is possible to apply an experimental evidence code and only if no other experimental evidence exists for an equivalent in vivo subcellular location.
cellular_component
Peripheral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH.
PMID:10512869
http://purl.org/obo/owl/PMID#PMID_10512869
extrinsic to vacuolar membrane
cellular_component
Loosely bound to one or the other surface of the vacuolar membrane, but not integrated into the hydrophobic region.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
cyclin-dependent protein kinase holoenzyme complex
cellular_component
CDK holoenzyme
Cyclin-dependent protein kinases (CDKs) are heterodimeric enzymes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
PMID:11602261
http://purl.org/obo/owl/PMID#PMID_11602261
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
cytoplasmic cyclin-dependent protein kinase holoenzyme complex
cellular_component
Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
CDK holoenzyme
plastid large ribosomal subunit
cellular_component
The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
plastid small ribosomal subunit
cellular_component
The smaller of the two subunits of a plastid ribosome.
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
organellar ribosome
cellular_component
A ribosome contained within a subcellular membrane-bounded organelle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
organellar small ribosomal subunit
cellular_component
The smaller of the two subunits of an organellar ribosome.
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
organellar large ribosomal subunit
cellular_component
The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
storage vacuole
cellular_component
A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
lytic vacuole
cellular_component
A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
fungal-type vacuole
cellular_component
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0879693649
http://purl.org/obo/owl/ISBN#ISBN_0879693649
vacuole, cell cycle-correlated morphology
plant-type vacuole
cellular_component
vacuole, cell cycle-independent morphology
A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0815316208
http://purl.org/obo/owl/ISBN#ISBN_0815316208
protein storage vacuole
cellular_component
A storage vacuole that contains a lytic vacuole; identified in plants.
PMID:11739409
http://purl.org/obo/owl/PMID#PMID_11739409
lytic vacuole within protein storage vacuole
cellular_component
A membrane-bounded compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole.
PMID:11739490
http://purl.org/obo/owl/PMID#PMID_11739490
fungal-type vacuole lumen
cellular_component
The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
lumen of vacuole with cell cycle-correlated morphology
fungal-type vacuole membrane
cellular_component
fungal-type vacuolar membrane
The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
membrane of vacuole with cell cycle-correlated morphology
plant-type vacuole lumen
cellular_component
The volume enclosed within the vacuolar membrane of a vacuole that retains the same shape regardless of cell cycle phase. An example of this is found in Arabidopsis thaliana.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
lumen of vacuole with cell cycle-independent morphology
contractile vacuole
cellular_component
Wikipedia:Contractile_vacuole
http://purl.org/obo/owl/Wikipedia#Wikipedia_Contractile_vacuole
A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. Its function is probably osmoregulatory.
PMID:10503189
http://purl.org/obo/owl/PMID#PMID_10503189
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
telomerase catalytic core complex
cellular_component
The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition.
PMID:11884619
http://purl.org/obo/owl/PMID#PMID_11884619
plastid-encoded plastid RNA polymerase complex A
cellular_component
A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex.
PMID:10946105
http://purl.org/obo/owl/PMID#PMID_10946105
PEP-A
plastid-encoded plastid RNA polymerase complex B
cellular_component
PEP-B
A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation.
PMID:10946105
http://purl.org/obo/owl/PMID#PMID_10946105
cytosolic DNA-directed RNA polymerase complex
cellular_component
The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity.
PMID:11158566
http://purl.org/obo/owl/PMID#PMID_11158566
transcription export complex
cellular_component
TREX complex
The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans.
PMID:11979277
http://purl.org/obo/owl/PMID#PMID_11979277
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
THO complex
cellular_component
The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:11979277
http://purl.org/obo/owl/PMID#PMID_11979277
PMID:11060033
http://purl.org/obo/owl/PMID#PMID_11060033
PMID:16983072
http://purl.org/obo/owl/PMID#PMID_16983072
cellular bud neck septin structure
cellular_component
Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
pre-autophagosomal structure
cellular_component
perivacuolar space
phagophore assembly site
isolation membrane
phagophore
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
PAS
A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
PMID:12048214
http://purl.org/obo/owl/PMID#PMID_12048214
PMID:11689437
http://purl.org/obo/owl/PMID#PMID_11689437
PMID:12554655
http://purl.org/obo/owl/PMID#PMID_12554655
EKC/KEOPS complex
cellular_component
Kinase, putative Endopeptidase and Other Proteins of Small size protein complex
Endopeptidase-like Kinase Chromatin-associated protein complex
A protein complex proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
PMID:16874308
http://purl.org/obo/owl/PMID#PMID_16874308
PMID:16564010
http://purl.org/obo/owl/PMID#PMID_16564010
HIR complex
cellular_component
A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:16303565
http://purl.org/obo/owl/PMID#PMID_16303565
PMID:17180700
http://purl.org/obo/owl/PMID#PMID_17180700
HIRA complex
PMID:19620282
http://purl.org/obo/owl/PMID#PMID_19620282
PMID:20976105
http://purl.org/obo/owl/PMID#PMID_20976105
DNA-directed RNA polymerase IV complex
GO:0000420
cellular_component
DNA-directed RNA polymerase IVa complex
RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol IV is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. The largest and second-largest subunits of Pol IV are the catalytic subunits and share similarity with the corresponding subunits of other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase V, while the largest subunit is found only in RNAP IV complex.
PMID:15692015
http://purl.org/obo/owl/PMID#PMID_15692015
PMID:15766525
http://purl.org/obo/owl/PMID#PMID_15766525
PMID:16140984
http://purl.org/obo/owl/PMID#PMID_16140984
PMID:19110459
http://purl.org/obo/owl/PMID#PMID_19110459
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
DNA-directed RNA polymerase V complex
GO:0080137
cellular_component
DNA-directed RNA polymerase IVb complex
RNA polymerase V is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol V is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensus sequence as well as other sequences. The remainder of the complex is composed of smaller subunits.
PMID:19110459
http://purl.org/obo/owl/PMID#PMID_19110459
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:16140984
http://purl.org/obo/owl/PMID#PMID_16140984
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
autophagic vacuole membrane
cellular_component
autophagosome membrane
The lipid bilayer surrounding an autophagic vacuole, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
GOC:isa_complete
http://purl.org/obo/owl/GOC#GOC_isa_complete
plastid-encoded plastid RNA polymerase complex
cellular_component
An RNA polymerase complex containing polypeptides encoded by the plastid genome. Plastid-encoded DNA-directed RNA polymerases resemble eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:pj
http://purl.org/obo/owl/GOC#GOC_pj
DNA-directed RNA polymerase complex
cellular_component
A protein complex that possesses DNA-directed RNA polymerase activity.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
core TFIIH complex portion of holo TFIIH complex
cellular_component
The core TFIIH complex when it is part of the general transcription factor TFIIH. In S. cerevisiae, it is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p. In humans, it is composed of ERCC2, p62, p55, p44, p34.
PMID:14500720
http://purl.org/obo/owl/PMID#PMID_14500720
PMID:7813015
http://purl.org/obo/owl/PMID#PMID_7813015
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
core TFIIH complex
cellular_component
The 5 subunit core of TFIIH that has tightly associated subunits and is found in both the general transcription factor holo-TFIIH and in the nucleotide-excision repair factor 3 complex. In S. cerevisiae, it is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4. In humans, it is composed of XPD, p62, p55, p44, p34.
PMID:7813015
http://purl.org/obo/owl/PMID#PMID_7813015
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:14500720
http://purl.org/obo/owl/PMID#PMID_14500720
core TFIIH complex portion of NEF3 complex
cellular_component
The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). In S. cerevisiae, it is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. In humans, it is composed of ERCC2, p62, p55, p44, p34.
PMID:7813015
http://purl.org/obo/owl/PMID#PMID_7813015
PMID:14500720
http://purl.org/obo/owl/PMID#PMID_14500720
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
SSL2-core TFIIH complex
cellular_component
A complex which is part of both the general transcription factor TFIIH and the nucleotide-excision repair factor 3 complex. It is composed of the tightly associated 5 subunit core TFIIH subcomplex plus one additional, more loosely associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB.
PMID:7813015
http://purl.org/obo/owl/PMID#PMID_7813015
PMID:14500720
http://purl.org/obo/owl/PMID#PMID_14500720
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
SSL2-core TFIIH complex portion of NEF3 complex
cellular_component
The SSL2-core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). It is composed of the tightly associated 5 subunit core TFIIH subcomplex plus one additional, less tighly associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:14500720
http://purl.org/obo/owl/PMID#PMID_14500720
PMID:7813015
http://purl.org/obo/owl/PMID#PMID_7813015
SSL2-core TFIIH complex portion of holo TFIIH complex
cellular_component
The SSL2-core TFIIH complex when it is part of the general transcription factor TFIIH. It is composed of the tightly associated five subunit core TFIIH subcomplex plus one additional, less tighly associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:7813015
http://purl.org/obo/owl/PMID#PMID_7813015
PMID:14500720
http://purl.org/obo/owl/PMID#PMID_14500720
MIS12/MIND type complex
cellular_component
A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1.
PMID:16585270
http://purl.org/obo/owl/PMID#PMID_16585270
PMID:14633972
http://purl.org/obo/owl/PMID#PMID_14633972
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
Mis12 complex
THO complex part of transcription export complex
cellular_component
The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.
PMID:11979277
http://purl.org/obo/owl/PMID#PMID_11979277
PMID:16983072
http://purl.org/obo/owl/PMID#PMID_16983072
PMID:11060033
http://purl.org/obo/owl/PMID#PMID_11060033
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
THO complex part of TREX complex
nucleoplasmic THO complex
cellular_component
The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.
PMID:16983072
http://purl.org/obo/owl/PMID#PMID_16983072
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:11060033
http://purl.org/obo/owl/PMID#PMID_11060033
PMID:11979277
http://purl.org/obo/owl/PMID#PMID_11979277
RNA polymerase I upstream activating factor complex
cellular_component
A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p.
PMID:11500378
http://purl.org/obo/owl/PMID#PMID_11500378
RNA polymerase I upstream activation factor complex
UAF
proteasome complex
cellular_component
26S proteasome
A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
proteasome regulatory particle (sensu Bacteria)
This term was made obsolete because there is no ubiquitin in bacteria and they do not have proteasome regulatory particles. Instead they have proteasome-activating nucleotidase.
cellular_component
26S proteasome
OBSOLETE. A multisubunit complex that recognizes and unfolds ubiquitinated proteins, and translocates them to the core complex in an ATP dependent manner. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2).
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
Note that this term should not be confused with 'GPI-anchor transamidase complex ; GO:0042765', which represents a distinct complex with a different catalytic activity.
cellular_component
An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast.
PMID:10944123
http://purl.org/obo/owl/PMID#PMID_10944123
PMID:15163411
http://purl.org/obo/owl/PMID#PMID_15163411
GOC:kp
http://purl.org/obo/owl/GOC#GOC_kp
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
GPI-GlcNAc transferase complex
GPI-GnT complex
GPI-N-acetylglucosaminyltransferase complex
chromosome, centromeric region
Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
cellular_component
chromosome, centric region
centromere
The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
chromosome, pericentric region
kinetochore
GO:0005699
cellular_component
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
Wikipedia:Kinetochore
http://purl.org/obo/owl/Wikipedia#Wikipedia_Kinetochore
condensed chromosome kinetochore
cellular_component
A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
condensed nuclear chromosome kinetochore
cellular_component
A multisubunit complex that is located at the centromeric region of a condensed chromosome in the nucleus and provides an attachment point for the spindle microtubules.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
condensed chromosome, centromeric region
Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
cellular_component
condensed chromosome, centric region
The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
condensed chromosome, centromere
condensed chromosome, pericentric region
condensed nuclear chromosome, centromeric region
Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
cellular_component
condensed nuclear chromosome, pericentric region
The region of a condensed chromosome in the nucleus that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
condensed nuclear chromosome, centromere
condensed nuclear chromosome, centric region
chromosome, telomeric region
Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
cellular_component
telomere
The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
telomere cap complex
Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome.
cellular_component
A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
nuclear telomere cap complex
Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome.
cellular_component
A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
nuclear chromosome, telomeric region
Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
cellular_component
nuclear chromosome, telomere
The terminal region of a linear chromosome in the nucleus that includes the telomeric DNA repeats and associated proteins.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
chromatin
GO:0005717
cellular_component
NIF_Subcellular:sao1615953555
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1615953555
chromosome scaffold
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
PMID:20404130
http://purl.org/obo/owl/PMID#PMID_20404130
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
nucleosome
cellular_component
GO:0005718
A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
Wikipedia:Nucleosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Nucleosome
cytoplasmic nucleosome
cellular_component
A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the cytoplasm into higher order structures.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
nuclear nucleosome
cellular_component
A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
cytoplasmic chromatin
cellular_component
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the cytoplasm.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
PMID:20404130
http://purl.org/obo/owl/PMID#PMID_20404130
nuclear chromatin
cellular_component
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
PMID:20404130
http://purl.org/obo/owl/PMID#PMID_20404130
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
euchromatin
cellular_component
Wikipedia:Euchromatin
http://purl.org/obo/owl/Wikipedia#Wikipedia_Euchromatin
A dispersed and relatively uncompacted form of chromatin.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
NIF_Subcellular:sao445485807
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao445485807
heterochromatin
cellular_component
Wikipedia:Heterochromatin
http://purl.org/obo/owl/Wikipedia#Wikipedia_Heterochromatin
NIF_Subcellular:sao581845896
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao581845896
A compact and highly condensed form of chromatin.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
condensed chromosome
Note that this term can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes an 'open mitosis' in which the nuclear envelope breaks down during mitosis.
cellular_component
cytoplasmic mitotic chromosome
metaphase chromosome
mitotic chromosome
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
condensed nuclear chromosome
Note that this term and its children can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes a 'closed mitosis' in which the nuclear envelope does not break down during mitosis and for gene products that localize to a meiotic chromosome.
cellular_component
nuclear mitotic chromosome
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
meiotic chromosome
synaptonemal complex
GO:0005716
cellular_component
A proteinaceous scaffold found between homologous chromosomes during meiosis.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
Wikipedia:Synaptonemal_complex
http://purl.org/obo/owl/Wikipedia#Wikipedia_Synaptonemal_complex
condensin complex
GO:0005676
GO:0008620
cellular_component
A multisubunit protein complex that plays a central role in chromosome condensation.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
SMC complex
13S condensin complex
condensin core heterodimer
GO:0008621
cellular_component
8S condensin complex
The core heterodimer of a condensin complex, a multisubunit protein complex that plays a central role in chromosome condensation.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
Smc2-Smc4 complex
nuclear cohesin complex
Note that this term and its children should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i.e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used.
cellular_component
A cohesin complex required for cohesion between sister chromatids that remain in the nucleus.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
nuclear condensin complex
cellular_component
A multisubunit protein complex that plays a central role in the condensation of chromosomes that remain in the nucleus.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
lateral element
cellular_component
axial element
GOC:ascb_2009
http://purl.org/obo/owl/GOC#GOC_ascb_2009
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
A proteinaceous core found between sister chromatids during meiotic prophase.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
central element
cellular_component
A structural unit of the synaptonemal complex found between the lateral elements.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
transverse filament
cellular_component
A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
sex chromosome
cellular_component
A chromosome involved in sex determination.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
W chromosome
cellular_component
Wikipedia:ZW_sex-determination_system
http://purl.org/obo/owl/Wikipedia#Wikipedia_ZW_sex-determination_system
The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females.
ISBN:0321000382
http://purl.org/obo/owl/ISBN#ISBN_0321000382
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
X chromosome
cellular_component
The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males.
ISBN:0582227089
http://purl.org/obo/owl/ISBN#ISBN_0582227089
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Wikipedia:X_chromosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_X_chromosome
Y chromosome
cellular_component
The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males.
ISBN:0582227089
http://purl.org/obo/owl/ISBN#ISBN_0582227089
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Wikipedia:Y_chromosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Y_chromosome
Z chromosome
cellular_component
Wikipedia:ZW_sex-determination_system
http://purl.org/obo/owl/Wikipedia#Wikipedia_ZW_sex-determination_system
The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females.
ISBN:0321000382
http://purl.org/obo/owl/ISBN#ISBN_0321000382
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
origin recognition complex
cellular_component
origin of replication recognition complex
Wikipedia:Origin_recognition_complex
http://purl.org/obo/owl/Wikipedia#Wikipedia_Origin_recognition_complex
A multisubunit complex that is located at the replication origins of a chromosome.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
ORC
cytoplasmic origin of replication recognition complex
cellular_component
A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
cytoplasmic ORC
prokaryotic ORC
GINS complex
cellular_component
A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks.
PMID:16990792
http://purl.org/obo/owl/PMID#PMID_16990792
PMID:17467990
http://purl.org/obo/owl/PMID#PMID_17467990
GOC:rn
http://purl.org/obo/owl/GOC#GOC_rn
PMID:12730134
http://purl.org/obo/owl/PMID#PMID_12730134
Go, Ichi, Ni and San complex
Swr1 complex
cellular_component
SWR-C
A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.
PMID:14690608
http://purl.org/obo/owl/PMID#PMID_14690608
PMID:14645854
http://purl.org/obo/owl/PMID#PMID_14645854
ESCRT I complex
cellular_component
Endosomal Sorting Complex Required for Transport
An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes.
PMID:12900393
http://purl.org/obo/owl/PMID#PMID_12900393
PMID:12892785
http://purl.org/obo/owl/PMID#PMID_12892785
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
ESCRT II complex
cellular_component
An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes.
PMID:12900393
http://purl.org/obo/owl/PMID#PMID_12900393
PMID:12892785
http://purl.org/obo/owl/PMID#PMID_12892785
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
Endosomal Sorting Complex Required for Transport
ESCRT III complex
cellular_component
An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes.
PMID:12900393
http://purl.org/obo/owl/PMID#PMID_12900393
PMID:12892785
http://purl.org/obo/owl/PMID#PMID_12892785
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
Endosomal Sorting Complex Required for Transport
COMA complex
cellular_component
A multiprotein complex in yeast consisting of Ctf19p, Okp1p, Mcm21p, and Ame1p. This complex bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly.
GOC:se
http://purl.org/obo/owl/GOC#GOC_se
PMID:14633972
http://purl.org/obo/owl/PMID#PMID_14633972
Ctf19p-Okp1p-Mcm1p-Ame1p complex
nuclear MIS12/MIND type complex
cellular_component
A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:14633972
http://purl.org/obo/owl/PMID#PMID_14633972
GOC:se
http://purl.org/obo/owl/GOC#GOC_se
Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex
MIND complex
ER ubiquitin ligase complex
cellular_component
A ubiquitin ligase complex found in the ER.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
Hrd1p ubiquitin ligase complex
cellular_component
A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
PMID:16873066
http://purl.org/obo/owl/PMID#PMID_16873066
Doa10p ubiquitin ligase complex
cellular_component
A multiprotein complex that recognizes and ubiquitinates membranes proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
PMID:16873066
http://purl.org/obo/owl/PMID#PMID_16873066
Ssm4p ubiquitin ligase complex
Hrd1p ubiquitin ligase ERAD-M complex
cellular_component
A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
PMID:16873066
http://purl.org/obo/owl/PMID#PMID_16873066
Hrd1p ubiquitin ligase ERAD-L complex
cellular_component
A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
PMID:16873066
http://purl.org/obo/owl/PMID#PMID_16873066
PMID:16873065
http://purl.org/obo/owl/PMID#PMID_16873065
spindle pole
GO:0030615
cellular_component
Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
equatorial microtubule organizing center
cellular_component
A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis.
PMID:11792817
http://purl.org/obo/owl/PMID#PMID_11792817
EMTOC
equatorial microtubule organising centre
gamma-tubulin ring complex, centrosomal
cellular_component
GO:0000925
GO:0000926
gamma-tubulin large complex, centrosomal
A centrosome-localized multiprotein complex composed of gamma-tubulin and other non-tubulin proteins assembled into a ring structure that is thought to be the unit of nucleation at the minus end of a microtubule. Gamma-tubulin small complexes are thought to be the core repeating units of the ring.
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
PMID:17021256
http://purl.org/obo/owl/PMID#PMID_17021256
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:12134075
http://purl.org/obo/owl/PMID#PMID_12134075
gamma-tubulin small complex, centrosomal
cellular_component
A centrosomal complex usually comprising two gamma-tubulin molecules, at least two conserved non-tubulin proteins that multimerize along with additional non-tubulin proteins in animal cells into larger functional complexes. Gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex. An example of this structure is found in Mus musculus.
PMID:12134075
http://purl.org/obo/owl/PMID#PMID_12134075
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
gamma-tubulin small complex, spindle pole body
cellular_component
Tub4 complex
A complex composed of two gamma-tubulin molecules and conserved non-tubulin proteins isolated by fractionation from cells. The complex, approximately 6S-9S, is analogous to the small complex in animal cells but contains fewer subunits, and is not thought to multimerize into larger functional units, like complexes in those organisms. An example of this structure is found in Saccharomyces cerevisiae.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:12134075
http://purl.org/obo/owl/PMID#PMID_12134075
gamma-tubulin complex
cellular_component
A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species.
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
PMID:12134075
http://purl.org/obo/owl/PMID#PMID_12134075
gamma-tubulin large complex
cellular_component
GO:0000929
A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe.
PMID:12134075
http://purl.org/obo/owl/PMID#PMID_12134075
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
cytoplasmic mRNA processing body
cellular_component
cytoplasmic foci
P-body
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci.
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
PMID:12730603
http://purl.org/obo/owl/PMID#PMID_12730603
P body
Wikipedia:P_body
http://purl.org/obo/owl/Wikipedia#Wikipedia_P_body
adventitious septum
cellular_component
A cell septum whose formation is independent of nuclear division.
ISBN:0471940526
http://purl.org/obo/owl/ISBN#ISBN_0471940526
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
porous cell septum
cellular_component
A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments.
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
porous septum
barrier septum
cellular_component
A septum which spans a cell and does not allow exchange of organelles or cytoplasm between compartments.
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
complete septum
primary cell septum
cellular_component
primary septum
A cell septum that forms following nuclear division.
ISBN:0471940526
http://purl.org/obo/owl/ISBN#ISBN_0471940526
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
dolipore septum
cellular_component
A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome).
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
GARP complex
cellular_component
Golgi associated retrograde protein complex
VFT tethering complex
Vps fifty three tethering complex
A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles.
PMID:10637310
http://purl.org/obo/owl/PMID#PMID_10637310
PMID:12077354
http://purl.org/obo/owl/PMID#PMID_12077354
PMID:12446664
http://purl.org/obo/owl/PMID#PMID_12446664
GOC:rn
http://purl.org/obo/owl/GOC#GOC_rn
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
condensed chromosome inner kinetochore
cellular_component
inner centromere core complex
inner kinetochore of condensed chromosome
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome.
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
PMID:11483983
http://purl.org/obo/owl/PMID#PMID_11483983
PMID:10619130
http://purl.org/obo/owl/PMID#PMID_10619130
inner kinetochore plate
condensed chromosome outer kinetochore
cellular_component
The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.
PMID:11483983
http://purl.org/obo/owl/PMID#PMID_11483983
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
outer kinetochore plate
outer kinetochore of condensed chromosome
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
condensed nuclear chromosome inner kinetochore
cellular_component
The region of a condensed nuclear chromosome kinetochore closest to centromeric DNA; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome.
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
PMID:10619130
http://purl.org/obo/owl/PMID#PMID_10619130
PMID:1148398
http://purl.org/obo/owl/PMID#PMID_1148398
inner kinetochore of condensed nuclear chromosome
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
condensed nuclear chromosome outer kinetochore
cellular_component
outer kinetochore of condensed nuclear chromosome
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
The region of a condensed nuclear chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.
PMID:1148398
http://purl.org/obo/owl/PMID#PMID_1148398
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
retrotransposon nucleocapsid
cellular_component
VLP
A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog.
PMID:10861903
http://purl.org/obo/owl/PMID#PMID_10861903
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
Virus-like particle
Wikipedia:Virus-like_particle
http://purl.org/obo/owl/Wikipedia#Wikipedia_Virus-like_particle
Prp19 complex
cellular_component
nineteen complex
NTC
Prp19/CDC5 complex
A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p.
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
PMID:16540691
http://purl.org/obo/owl/PMID#PMID_16540691
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
protein-DNA-RNA complex
cellular_component
A macromolecular complex containing protein, DNA, and RNA molecules.
GOC:txnOH
http://purl.org/obo/owl/GOC#GOC_txnOH
mating projection base
cellular_component
conjugation tube base
base of shmoo tip
The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone.
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
mitochondrial sorting and assembly machinery complex
See also the cellular component term 'mitochondrial outer membrane translocase complex ; GO:0005742'.
cellular_component
TOB complex
SAM complex
A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex.
PMID:12891361
http://purl.org/obo/owl/PMID#PMID_12891361
presequence translocase-associated import motor
cellular_component
mitochondrial import motor
PAM complex
Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the presequence translocase complex; hydrolyzes ATP to provide the force to drive import of proteins into the mitochondrial matrix.
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
PMID:14517234
http://purl.org/obo/owl/PMID#PMID_14517234
PMID:14638855
http://purl.org/obo/owl/PMID#PMID_14638855
pre-sequence translocase-associated import motor
hyphal tip
cellular_component
The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation.
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
voltage-gated sodium channel complex
cellular_component
voltage-dependent sodium channel complex
voltage-sensitive sodium channel complex
voltage gated sodium channel complex
A sodium channel in a cell membrane whose opening is governed by the membrane potential.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
NIF_Subcellular:sao785001660
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao785001660
outer dense fiber
cellular_component
outer dense fibre
Structure or material found in the flagella of mammalian sperm that surrounds each of the nine microtubule doublets, giving a 9 + 9 + 2 arrangement rather than the 9 + 2 pattern usually seen. These dense fibers are stiff and noncontractile.
ISBN:0824072820
http://purl.org/obo/owl/ISBN#ISBN_0824072820
microfibril
cellular_component
Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins.
URL:http://www.xrefer.com/entry/490235
http://www.xrefer.com/entry/490235
fibrillin
extended fibrils
elastin
This term was made obsolete because it represents a gene product.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cornified envelope
cellular_component
An insoluble protein structure formed under the plasma membrane of cornifying epithelial cells.
PMID:11112355
http://purl.org/obo/owl/PMID#PMID_11112355
radial spoke
cellular_component
Wikipedia:Radial_spoke
http://purl.org/obo/owl/Wikipedia#Wikipedia_Radial_spoke
Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules.
PMID:9450971
http://purl.org/obo/owl/PMID#PMID_9450971
ISBN:0124325653
http://purl.org/obo/owl/ISBN#ISBN_0124325653
radial spokehead
cellular_component
Protein complex forming part of eukaryotic flagellar apparatus.
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
radial spoke stalk
cellular_component
Globular portion of the radial spoke that projects towards the central pair of microtubules.
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
fibrillar center
cellular_component
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
PMID:10754561
http://purl.org/obo/owl/PMID#PMID_10754561
fibrillar centre
dense fibrillar component
cellular_component
A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins.
PMID:10754561
http://purl.org/obo/owl/PMID#PMID_10754561
granular component
cellular_component
A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm.
PMID:10754561
http://purl.org/obo/owl/PMID#PMID_10754561
acrosomal vesicle
cellular_component
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
ISBN:0124325653
http://purl.org/obo/owl/ISBN#ISBN_0124325653
acrosome
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
Wikipedia:Acrosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Acrosome
acrosomal granule
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
male germ cell nucleus
cellular_component
GO:0043081
male germ-cell nucleus
The nucleus of a male germ cell, a reproductive cell in males.
CL:0000015
http://purl.org/obo/owl/CL#CL_0000015
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
female germ cell nucleus
cellular_component
GO:0043080
The nucleus of the female germ cell, a reproductive cell in females.
CL:0000021
http://purl.org/obo/owl/CL#CL_0000021
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
female germ-cell nucleus
axonemal dynein heavy chain
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
axonemal dynein intermediate chain
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
axonemal dynein intermediate light chain
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
axonemal dynein light chain
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
cytoplasmic dynein heavy chain
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
cytoplasmic dynein intermediate chain
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
cytoplasmic dynein intermediate light chain
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
cytoplasmic dynein light chain
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
intermediate filament associated protein
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
IFAP
OBSOLETE. Proteins that associate with intermediate filaments and function in the supramolecular organization of cellular intermediate filament networks.
GOC:ajp
http://purl.org/obo/owl/GOC#GOC_ajp
PMID:9484600
http://purl.org/obo/owl/PMID#PMID_9484600
type I intermediate filament associated protein
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
OBSOLETE. Low molecular weight (10-45 kDa) proteins that associate with intermediate filaments by lateral binding of the filaments and have the effect of creating tight macrofilament aggregates.
PMID:9484600
http://purl.org/obo/owl/PMID#PMID_9484600
GOC:ajp
http://purl.org/obo/owl/GOC#GOC_ajp
type II intermediate filament associated protein
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
OBSOLETE. High molecular weight (100-300 kDa) proteins that associate with intermediate filaments to cross-link them into loose networks.
PMID:9484600
http://purl.org/obo/owl/PMID#PMID_9484600
GOC:ajp
http://purl.org/obo/owl/GOC#GOC_ajp
type III intermediate filament associated protein
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
OBSOLETE. Proteins that associate with the ends of intermediate filaments and couple the intermediate filaments to the plasma membrane.
PMID:9484600
http://purl.org/obo/owl/PMID#PMID_9484600
GOC:ajp
http://purl.org/obo/owl/GOC#GOC_ajp
stress fiber
cellular_component
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
PMID:16651381
http://purl.org/obo/owl/PMID#PMID_16651381
stress fibre
actin cable
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ruffle
cellular_component
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
ISBN:0124325653
http://purl.org/obo/owl/ISBN#ISBN_0124325653
membrane ruffle
sex chromatin
cellular_component
A condensed mass of compacted chromatin that represents an inactivated X chromosome.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
Barr body
cellular_component
Wikipedia:Barr_body
http://purl.org/obo/owl/Wikipedia#Wikipedia_Barr_body
A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
XY body
cellular_component
A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
photoreceptor outer segment
cellular_component
The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes.
ISBN:0824072820
http://purl.org/obo/owl/ISBN#ISBN_0824072820
immunological synapse
cellular_component
An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
GOC:mgi_curators
http://purl.org/obo/owl/GOC#GOC_mgi_curators
PMID:11244041
http://purl.org/obo/owl/PMID#PMID_11244041
PMID:11376300
http://purl.org/obo/owl/PMID#PMID_11376300
c-SMAC
PMID:14724296
http://purl.org/obo/owl/PMID#PMID_14724296
supramolecular activation cluster
PMID:14724296
http://purl.org/obo/owl/PMID#PMID_14724296
Wikipedia:Immunological_synapse
http://purl.org/obo/owl/Wikipedia#Wikipedia_Immunological_synapse
phagocytic cup
cellular_component
An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.
PMID:10358769
http://purl.org/obo/owl/PMID#PMID_10358769
photoreceptor inner segment
cellular_component
The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
PMID:12019563
http://purl.org/obo/owl/PMID#PMID_12019563
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
uropod
cellular_component
A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
ISBN:0781735149
http://purl.org/obo/owl/ISBN#ISBN_0781735149
PMID:12714569
http://purl.org/obo/owl/PMID#PMID_12714569
PMID:12787750
http://purl.org/obo/owl/PMID#PMID_12787750
uropodium
distal pole complex
retractile pole
female pronucleus
cellular_component
The pronucleus originating from the ovum that is being fertilized.
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
male pronucleus
cellular_component
The pronucleus originating from the spermatozoa that was involved in fertilization.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
plasma membrane enriched fraction
Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. It is advised that this term should only be used in a manual annotation statement where it is possible to apply an experimental evidence code and only if no other experimental evidence exists for an equivalent in vivo subcellular location.
cellular_component
The fraction of cells, prepared by disruptive biochemical methods, that is enriched for plasma membranes.
GOC:mgi_curators
http://purl.org/obo/owl/GOC#GOC_mgi_curators
PMID:11562363
http://purl.org/obo/owl/PMID#PMID_11562363
PMID:15601832
http://purl.org/obo/owl/PMID#PMID_15601832
PME fraction
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
inner acrosomal membrane
Note that this term is not a descendant of 'organelle inner membrane ; GO:0019866' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer.
cellular_component
The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
PMID:3899643
http://purl.org/obo/owl/PMID#PMID_3899643
PMID:8936405
http://purl.org/obo/owl/PMID#PMID_8936405
acrosomal membrane
cellular_component
The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
outer acrosomal membrane
Note that this term is not a descendant of 'organelle outer membrane ; GO:0031968' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer.
cellular_component
The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
PMID:8936405
http://purl.org/obo/owl/PMID#PMID_8936405
caveolar macromolecular signaling complex
cellular_component
caveolar macromolecular signalling complex
A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3).
PMID:16648270
http://purl.org/obo/owl/PMID#PMID_16648270
polkadots
Note that polkadots also contains some amount of MALT1. Interaction with MALT1 is required for formation of the polkadots.
cellular_component
A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals.
PMID:16495340
http://purl.org/obo/owl/PMID#PMID_16495340
PMID:14724296
http://purl.org/obo/owl/PMID#PMID_14724296
podosome
Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
cellular_component
An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
PMID:12837608
http://purl.org/obo/owl/PMID#PMID_12837608
PMID:15890982
http://purl.org/obo/owl/PMID#PMID_15890982
Wikipedia:Podosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Podosome
BRCA2-BRAF35 complex
cellular_component
A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis.
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
PMID:11207365
http://purl.org/obo/owl/PMID#PMID_11207365
semaphorin receptor complex
cellular_component
A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.
PMID:12367632
http://purl.org/obo/owl/PMID#PMID_12367632
PMID:10934324
http://purl.org/obo/owl/PMID#PMID_10934324
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
PMID:12613544
http://purl.org/obo/owl/PMID#PMID_12613544
plexin-neurophilin complex
polycystin complex
Different forms of the complex differing in type of N-glycosylation of polycystin-1 can exist (endoglycosidase sensitive and endoglycosidase resistant).
cellular_component
A stable heterodimeric complex composed of polycystin-1 and polycystin-2.
PMID:11901144
http://purl.org/obo/owl/PMID#PMID_11901144
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
nuclear cluster
cellular_component
Discrete hetero-chromatin-containing foci in interphase nuclei, which comprise clusters of centromeric DNA (as defined by gamma-satellite sequences and the abundance of heterochromatin protein 1 (HP-1).
PMID:9413993
http://purl.org/obo/owl/PMID#PMID_9413993
stereocilia coupling link
cellular_component
A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle.
PMID:16775142
http://purl.org/obo/owl/PMID#PMID_16775142
stereocilia tip link
cellular_component
A stereocilia link that is formed by a fine filament running more or less vertically upward from the tip of each shorter stereocilium to attach at a higher point on its adjacent taller neighbor. Tilting the bundle puts tension on the filaments, which pull on mechanically gated ion channels in the membrane of the stereocilia.
PMID:1108787
http://purl.org/obo/owl/PMID#PMID_1108787
stereocilia ankle link
cellular_component
A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia.
PMID:17567809
http://purl.org/obo/owl/PMID#PMID_17567809
stereocilia ankle link complex
cellular_component
A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin.
PMID:16775142
http://purl.org/obo/owl/PMID#PMID_16775142
cytosolic tRNA wobble base thiouridylase complex
cellular_component
Cut1-Cut2 complex
tRNA thiouridylase
A complex of two proteins involved in the thiolation of U34 in glutamate, lysine, and glutamine tRNAs of eukaryotes.
PMID:18391219
http://purl.org/obo/owl/PMID#PMID_18391219
VRK3/VHR/ERK complex
cellular_component
A ternary complex consisting of VRK3, VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway.
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
PMID:16845380
http://purl.org/obo/owl/PMID#PMID_16845380
3-methylcrotonyl-CoA carboxylase complex, mitochondrial
cellular_component
A heterodimeric complex having 3-methylcrotonyl-CoA carboxylase activity. The alpha subunit has a covalently bound biotin essential for the ATP-dependent carboxylation. The beta subunit possess carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA.
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
PMID:15868465
http://purl.org/obo/owl/PMID#PMID_15868465
manchette
cellular_component
A conical shaped array of microtubules that completely covers the nucleus of a spermatid, thought to be involved in sperm head elongation.
PMID:15018141
http://purl.org/obo/owl/PMID#PMID_15018141
palmitoyltransferase complex
cellular_component
A protein complex with palmitoyltransferase activity.
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
homodimeric serine palmitoyltransferase complex
This complex occurs primarily in bacteria.
cellular_component
A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine.
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
5-lipoxygenase complex
cellular_component
An nuclear membrane protein complex having arachidonate 5-lipoxygenase activity.
PMID:19075240
http://purl.org/obo/owl/PMID#PMID_19075240
creatine kinase complex
cellular_component
A protein complex having creatine kinase activity.
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
cytosolic creatine kinase complex
cellular_component
A dimeric protein complex having creatine kinase activity.
PMID:173175
http://purl.org/obo/owl/PMID#PMID_173175
mitochondrial creatine kinase complex
cellular_component
An octomeric protein complex having creatine kinase activity.
PMID:16236486
http://purl.org/obo/owl/PMID#PMID_16236486
ribose phosphate diphosphokinase complex
In mammals, the complex consists of two non-identical catalytic subunits and two non-identical regulatory subunits.
cellular_component
phosphoribosylpyrophosphate synthetase complex
PMID:9348095
http://purl.org/obo/owl/PMID#PMID_9348095
PRPP synthetase complex
PMID:9348095
http://purl.org/obo/owl/PMID#PMID_9348095
A protein complex having ribose phosphate diphosphokinase activity.
GO:hjd
http://purl.org/obo/owl/GO#GO_hjd
PMID:9348095
http://purl.org/obo/owl/PMID#PMID_9348095
MAML1-RBP-Jkappa- ICN1 complex
cellular_component
MAML1-CSL-ICN1
MAML1-CSL-Notch1 complex
MAML1-RBP-Jkappa-Notch1 complex
A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
PMID:16510869
http://purl.org/obo/owl/PMID#PMID_16510869
CORUM:2949
http://purl.org/obo/owl/CORUM#CORUM_2949
xanthine dehydrogenase complex
cellular_component
A homodimeric protein complex having xanthine dehydrogenase activity.
PMID:8224915
http://purl.org/obo/owl/PMID#PMID_8224915
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
sperm protein complex
cellular_component
A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction.
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
PMID:21880732
http://purl.org/obo/owl/PMID#PMID_21880732
MECO complex
cellular_component
meta-coactivator complex
A highly stable complex composed of the ATAC complex and the mediator complex (also called TRAP or MED). MECO binds and regulates the transcription of a subset of non-coding RNAs transcribed by RNA polymerase II.
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
PMID:20508642
http://purl.org/obo/owl/PMID#PMID_20508642
protein
Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
ribozyme
Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
nucleic acid
Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
RNA
Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
cytosolic tRNA
Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
mitochondrial tRNA
Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
cytosolic ribosomal RNA
Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
mitochondrial rRNA
Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
untranslated RNA
Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
RNA polymerase II transcribed untranslated RNA
Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
telomerase RNA
This term was made obsolete because it represents a gene product.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
DNA
Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
cellular_component
Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
cellular_component
GO:0008372
cellular component
NIF_Subcellular:sao1337158144
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1337158144
cellular component unknown
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
extracellular region
Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'.
cellular_component
Wikipedia:Extracellular
http://purl.org/obo/owl/Wikipedia#Wikipedia_Extracellular
extracellular
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
fibrinogen complex
cellular_component
fibrinogen gamma chain
fibrinogen beta chain
fibrinogen alpha chain
A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
fibrinogen
proteinaceous extracellular matrix
cellular_component
A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
membrane attack complex
cellular_component
membrane attack complex protein beta2 chain
membrane attack complex protein alphaM chain
A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
ISBN:0781735149
http://purl.org/obo/owl/ISBN#ISBN_0781735149
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
ISBN:068340007X
http://purl.org/obo/owl/ISBN#ISBN_068340007X
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
Wikipedia:Complement_membrane_attack_complex
http://purl.org/obo/owl/Wikipedia#Wikipedia_Complement_membrane_attack_complex
MAC
TCC
terminal complement complex
membrane attack complex protein alphaM chain
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
collagen
cellular_component
Wikipedia:Collagen
http://purl.org/obo/owl/Wikipedia#Wikipedia_Collagen
other collagen
Any of the various assemblies in which collagen chains form a left-handed triple helix; may assemble into higher order structures.
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
collagen type XV
cellular_component
A collagen homotrimer of alpha1(XV) chains; a chondroitin sulfate proteoglycan often found in specialized basement membranes.
PMID:11937714
http://purl.org/obo/owl/PMID#PMID_11937714
PMID:11158616
http://purl.org/obo/owl/PMID#PMID_11158616
fibrillar collagen
cellular_component
Any collagen polymer in which collagen triple helices associate to form fibrils.
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
collagen type I
cellular_component
A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils.
GOC:sl
http://purl.org/obo/owl/GOC#GOC_sl
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Wikipedia:Collagen_type_I
http://purl.org/obo/owl/Wikipedia#Wikipedia_Collagen_type_I
collagen type II
cellular_component
A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils.
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
Wikipedia:Collagen_type_II
http://purl.org/obo/owl/Wikipedia#Wikipedia_Collagen_type_II
collagen type III
cellular_component
A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils.
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
collagen type IV
cellular_component
Wikipedia:Collagen_type_IV
http://purl.org/obo/owl/Wikipedia#Wikipedia_Collagen_type_IV
A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form nets within basement membranes.
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
collagen type V
cellular_component
A collagen heterotrimer containing type V alpha chains; [alpha1(V)]2alpha2(V) and alpha1(V)alpha2(V)alpha3(V) trimers have been observed; type V collagen triple helices associate to form fibrils.
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
collagen type VI
cellular_component
A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils.
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
collagen type VII
cellular_component
A collagen homotrimer of alpha1(VII) chains; type VII collagen triple helices form antiparallel dimer, which in turn associate laterally to form anchoring fibrils that connect type IV collagen in the basal lamina to plaques in the underlying connective tissue.
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
collagen type VIII
cellular_component
A collagen heterotrimer containing type VIII alpha chains; [alpha1(VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets.
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
collagen type XI
cellular_component
A collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils.
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
FACIT collagen
cellular_component
Any collagen polymer associated with collagen fibrils and in which the collagen monomers contain two or more relatively short triple-helical domains connected by non-triple-helical sequences; the acronym FACIT stands for fibril-associated collagen with interrupted triple helix.
ISBN:0198599587
http://purl.org/obo/owl/ISBN#ISBN_0198599587
Wikipedia:FACIT_collagen
http://purl.org/obo/owl/Wikipedia#Wikipedia_FACIT_collagen
collagen type IX
cellular_component
A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils.
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
collagen type XII
cellular_component
A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures.
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
collagen type XIV
cellular_component
A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures.
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
collagen type XVI
cellular_component
A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:12782140
http://purl.org/obo/owl/PMID#PMID_12782140
short-chain collagen
cellular_component
Any assembly of collagen in which the collagen chains are relatively short compared to the fibrillar collagens.
ISBN:0198599587
http://purl.org/obo/owl/ISBN#ISBN_0198599587
collagen type X
cellular_component
A collagen homotrimer of alpha1(X) chains; type X collagen triple helices may form nets.
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
collagen type XIII
cellular_component
A collagen homotrimer of alpha1(XIII) chains; type X collagen triple helices span lipid bilayer membranes.
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
classical-complement-pathway C3/C5 convertase complex
cellular_component
A heterodimeric protein complex that catalyzes the cleavage of complement components C3 and C5, and acts in the classical pathway of complement activation; consists of one monomer of C2a and one monomer of C4b; C2a is the catalytic subunit, but cannot catalyze cleavage alone.
BRENDA:3.4.21.43
http://purl.org/obo/owl/BRENDA#BRENDA_3.4.21.43
URL:http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Complement.html
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Complement.html
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
complement component C1 complex
cellular_component
A protein complex composed of six subunits of C1q, each formed of the three homologous polypeptide chains C1QA, C1QB, and C1QB, and tetramer of two C1QR and two C1QS polypeptide chains.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
ISBN:0781735149
http://purl.org/obo/owl/ISBN#ISBN_0781735149
complement component C1q complex
complement component C2 complex
This term was made obsolete because prior to cleavage, complement component C2 is a single polypeptide rather than a complex, and after cleavage the products do not remain physically associated; there is thus no known biological entity corresponding to "complement C2 complex".
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
basement membrane
Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer.
cellular_component
Wikipedia:Basement_membrane
http://purl.org/obo/owl/Wikipedia#Wikipedia_Basement_membrane
A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
basal lamina
cellular_component
Wikipedia:Basal_lamina
http://purl.org/obo/owl/Wikipedia#Wikipedia_Basal_lamina
A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
NIF_Subcellular:sao1397492660
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1397492660
basement lamina
laminin-1 complex
cellular_component
A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:10842354
http://purl.org/obo/owl/PMID#PMID_10842354
laminin-2 complex
cellular_component
A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:10842354
http://purl.org/obo/owl/PMID#PMID_10842354
laminin-3 complex
cellular_component
A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains.
MEDLINE:95005761
http://purl.org/obo/owl/MEDLINE#MEDLINE_95005761
laminin-4 complex
cellular_component
A laminin complex composed of alpha2, beta2 and gamma1 polypeptide chains.
PMID:10842354
http://purl.org/obo/owl/PMID#PMID_10842354
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
laminin-5 complex
cellular_component
A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:10842354
http://purl.org/obo/owl/PMID#PMID_10842354
laminin-6 complex
cellular_component
A laminin complex composed of alpha3, beta1 and gamma1 polypeptide chains.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:10842354
http://purl.org/obo/owl/PMID#PMID_10842354
laminin-7 complex
cellular_component
A laminin complex composed of alpha3, beta2 and gamma1 polypeptide chains.
PMID:10842354
http://purl.org/obo/owl/PMID#PMID_10842354
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
laminin receptor protein
This term was made obsolete because it is out of date. It seems to be referring to the non-integrin 34/67kDa laminin receptor, which new research has shown to actually be a ribosomal protein of the SP2 family.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
interstitial matrix
cellular_component
A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens.
PMID:8450001
http://purl.org/obo/owl/PMID#PMID_8450001
extracellular space
Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term.
cellular_component
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
NIF_Subcellular:sao1425028079
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1425028079
intercellular space
larval serum protein complex
cellular_component
A multisubunit protein complex which, in Drosophila, is a heterohexamer of three subunits, alpha, beta and gamma. The complex is thought to store amino acids for synthesis of adult proteins.
PMID:6781759
http://purl.org/obo/owl/PMID#PMID_6781759
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
larval serum protein-1
This term was made obsolete because it represents a gene product.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
LSP1
cell wall
cellular_component
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
Wikipedia:Cell_wall
http://purl.org/obo/owl/Wikipedia#Wikipedia_Cell_wall
ascospore wall
cellular_component
The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi.
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
ISBN:0879693568
http://purl.org/obo/owl/ISBN#ISBN_0879693568
fungal-type spore wall
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cellular bud scar
cellular_component
Crater-like ring of chitinous scar tissue located on the surface of the mother cell. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis and septation. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age.
GOC:rn
http://purl.org/obo/owl/GOC#GOC_rn
PMID:14600225
http://purl.org/obo/owl/PMID#PMID_14600225
PMID:2005820
http://purl.org/obo/owl/PMID#PMID_2005820
intracellular
cellular_component
nucleocytoplasm
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
internal to cell
protoplasm
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
Wikipedia:Intracellular
http://purl.org/obo/owl/Wikipedia#Wikipedia_Intracellular
protoplast
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cell
cellular_component
NIF_Subcellular:sao1813327414
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1813327414
Wikipedia:Cell_(biology)
http://purl.org/obo/owl/Wikipedia#Wikipedia_Cell_(biology)
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
membrane fraction
Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. It is advised that this term should only be used in a manual annotation statement where it is possible to apply an experimental evidence code and only if no other experimental evidence exists for an equivalent in vivo subcellular location.
cellular_component
That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes.
GOC:ma
http://purl.org/obo/owl/GOC#GOC_ma
soluble fraction
Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. It is advised that this term should only be used in a manual annotation statement where it is possible to apply an experimental evidence code and only if no other experimental evidence exists for an equivalent in vivo subcellular location.
cellular_component
That fraction of cells, prepared by disruptive biochemical methods, that is soluble in water.
GOC:ma
http://purl.org/obo/owl/GOC#GOC_ma
soluble
insoluble fraction
Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. It is advised that this term should only be used in a manual annotation statement where it is possible to apply an experimental evidence code and only if no other experimental evidence exists for an equivalent in vivo subcellular location.
cellular_component
That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water.
GOC:ma
http://purl.org/obo/owl/GOC#GOC_ma
particle-bound
ascus
This term was made obsolete because it is a type of cell rather than a cellular component. To update annotations, consider the external ontology term 'ascus ; FAO:0000014'.
cellular_component
OBSOLETE. A sac-like fruiting body (ascomycete Fungi); contains ascospores (typically eight in number).
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
prospore membrane
cellular_component
FSM
forespore membrane
The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe.
ISBN:0879693649
http://purl.org/obo/owl/ISBN#ISBN_0879693649
ascospore-type prospore membrane
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
dityrosine layer of spore wall
cellular_component
The outermost layer of the spore wall, as described in Saccharomyces.
ISBN:0879693568
http://purl.org/obo/owl/ISBN#ISBN_0879693568
chitosan layer of spore wall
cellular_component
The second outermost layer of the spore wall, as described in Saccharomyces.
ISBN:0879693568
http://purl.org/obo/owl/ISBN#ISBN_0879693568
inner layer of spore wall
cellular_component
Either of the two innermost layers of the spore wall, as described in Saccharomyces.
ISBN:0879693568
http://purl.org/obo/owl/ISBN#ISBN_0879693568
ascus lipid particle
cellular_component
ascus lipid droplet
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
Any particle of coalesced lipids in an ascus or ascospore. May include associated proteins.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:12702293
http://purl.org/obo/owl/PMID#PMID_12702293
nucleus
cellular_component
Wikipedia:Cell_nucleus
http://purl.org/obo/owl/Wikipedia#Wikipedia_Cell_nucleus
cell nucleus
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
NIF_Subcellular:sao1702920020
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1702920020
nuclear envelope
cellular_component
GO:0005636
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
Wikipedia:Nuclear_envelope
http://purl.org/obo/owl/Wikipedia#Wikipedia_Nuclear_envelope
nuclear inner membrane
cellular_component
The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.
GOC:ma
http://purl.org/obo/owl/GOC#GOC_ma
inner envelope
NIF_Subcellular:sao1612527463
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1612527463
inner nuclear membrane
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:21411627
http://purl.org/obo/owl/PMID#PMID_21411627
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
lamin filament
cellular_component
type V intermediate filament
Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
integral to nuclear inner membrane
cellular_component
Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the nuclear inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
nuclear outer membrane
cellular_component
outer envelope
NIF_Subcellular:sao1617136075
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1617136075
The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
perinuclear membrane
nuclear envelope lumen
Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'.
cellular_component
GO:0005653
perinuclear space
nuclear membrane lumen
The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
nuclear intermembrane space
annulate lamellae
cellular_component
Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER.
PMID:12631728
http://purl.org/obo/owl/PMID#PMID_12631728
nuclear pore
GO:0005644
cellular_component
Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
NIF_Subcellular:sao220861693
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao220861693
Wikipedia:Nuclear_pore
http://purl.org/obo/owl/Wikipedia#Wikipedia_Nuclear_pore
nuclear pore membrane protein
nucleopore
GOC:al
http://purl.org/obo/owl/GOC#GOC_al
PMID:7603572
http://purl.org/obo/owl/PMID#PMID_7603572
nuclear pore complex
NPC
RAN-binding protein
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
importin
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
karyopherin
importin, alpha-subunit
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
karyopherin-alpha
importin, beta-subunit
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
karyopherin-beta1
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
transportin
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
karyopherin-beta2
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
importin, alpha-subunit transport factor
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
CAS
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
exportin
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
nuclear lamina
cellular_component
Wikipedia:Nuclear_lamina
http://purl.org/obo/owl/Wikipedia#Wikipedia_Nuclear_lamina
The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
ISBN:0716731363
http://purl.org/obo/owl/ISBN#ISBN_0716731363
NIF_Subcellular:sao1455996588
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1455996588
nucleoplasm
cellular_component
That part of the nuclear content other than the chromosomes or the nucleolus.
GOC:ma
http://purl.org/obo/owl/GOC#GOC_ma
ISBN:0124325653
http://purl.org/obo/owl/ISBN#ISBN_0124325653
NIF_Subcellular:sao661522542
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao661522542
Wikipedia:Nucleoplasm
http://purl.org/obo/owl/Wikipedia#Wikipedia_Nucleoplasm
nucleolar ribonuclease P complex
cellular_component
nucleolar RNase P complex
A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules.
PMID:12045094
http://purl.org/obo/owl/PMID#PMID_12045094
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
pre-replicative complex
cellular_component
A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins.
PMID:15222894
http://purl.org/obo/owl/PMID#PMID_15222894
pre-RC
replication fork
cellular_component
The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Wikipedia:Replication_fork
http://purl.org/obo/owl/Wikipedia#Wikipedia_Replication_fork
replication focus
alpha DNA polymerase:primase complex
cellular_component
DNA polymerase alpha:primase complex
heterotetrameric polymerase alpha holoenzyme
A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:11395402
http://purl.org/obo/owl/PMID#PMID_11395402
pol-prim
primosome
delta-DNA polymerase cofactor complex
This term was made obsolete because it refers to two distinct complexes, PCNA and Replication factor C (RFC), the latter of which is already represented as a separate, unrelated GO term (DNA replication factor C complex ; GO:0005663). In addition, the phrase 'delta-DNA polymerase cofactor' to represent both PCNA and RFC is not used in current literature.
cellular_component
OBSOLETE. A complex of proteins that interacts with delta-DNA polymerase, promoting elongation. In humans it is a heteropentamer of subunits of 140/145, 40, 38, 37 and 36.5 kDa, which form a complex with the proliferating cell nuclear antigen (PCNA) in the presence of ATP.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
delta DNA polymerase cofactor complex
DNA replication factor A complex
cellular_component
SSB
single-stranded DNA-binding protein complex
RPA
replication protein A
A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa.
PMID:9242902
http://purl.org/obo/owl/PMID#PMID_9242902
Wikipedia:Replication_protein_A
http://purl.org/obo/owl/Wikipedia#Wikipedia_Replication_protein_A
DNA replication factor C complex
cellular_component
activator 1 complex
RFC complex
A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase.
PMID:16172520
http://purl.org/obo/owl/PMID#PMID_16172520
PMID:14614842
http://purl.org/obo/owl/PMID#PMID_14614842
PMID:14646196
http://purl.org/obo/owl/PMID#PMID_14646196
nuclear origin of replication recognition complex
cellular_component
A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
eukaryotic ORC
nuclear ORC
DNA-directed RNA polymerase II, core complex
cellular_component
RNAP II complex
RNA polymerase II complex
RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
DNA-directed RNA polymerase III complex
cellular_component
RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
DNA-directed RNA polymerase III activity
transcription factor complex
cellular_component
A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
RNA polymerase transcription factor SL1 complex
cellular_component
TIF-IB
CORUM:480
http://purl.org/obo/owl/CORUM#CORUM_480
PMID:15691654
http://purl.org/obo/owl/PMID#PMID_15691654
selectivity factor SL1 complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48.
PMID:15691654
http://purl.org/obo/owl/PMID#PMID_15691654
transcription factor TFIID complex
cellular_component
A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
ISBN:0879695501
http://purl.org/obo/owl/ISBN#ISBN_0879695501
ISBN:0471953393
http://purl.org/obo/owl/ISBN#ISBN_0471953393
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
transcription-activating factor, 30kD
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
Ada2/Gcn5/Ada3 transcription activator complex
In human, this complex is composed of GCN5 or PCAF, ADA2a, ADA3, ZZZ3, ATAC2, SGF29, HCF1, WDR5,YEATS2, NC2-beta, and MBIP.
cellular_component
GO:0002928
Ada Two-A containing complex
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
PMID:18838386
http://purl.org/obo/owl/PMID#PMID_18838386
A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues.
PMID:10637607
http://purl.org/obo/owl/PMID#PMID_10637607
Ada-Two-A-containing complex
ATAC complex
PMID:18838386
http://purl.org/obo/owl/PMID#PMID_18838386
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
transcription factor TFIIA complex
cellular_component
A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).
PMID:17560669
http://purl.org/obo/owl/PMID#PMID_17560669
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
transcription factor TFIIE complex
cellular_component
A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH.
PMID:16547462
http://purl.org/obo/owl/PMID#PMID_16547462
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
transcription factor TFIIF complex
cellular_component
A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation.
PMID:7597077
http://purl.org/obo/owl/PMID#PMID_7597077
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
holo TFIIH complex
cellular_component
A complex that contains kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. In S. cerevisiae, it is composed of the 5-subunit core (Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p), Ssl2p, and TFIIK (Kin28p, Ccl1p, and Tfb3p). All of the subunits have equivalents in humans: the 5 subunit core is composed of ERCC2, p62, p55, p44, p34; the equivalent of the TFIIK subcomplex is composed of MO15, Mat1, and a cyclin; the human equivalent of Ssl2p is XPB.
PMID:14500720
http://purl.org/obo/owl/PMID#PMID_14500720
PMID:7813015
http://purl.org/obo/owl/PMID#PMID_7813015
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
chromatin silencing complex
cellular_component
Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
chromatin assembly complex
cellular_component
nucleosome assembly complex
Any protein complex that acts in the formation of nucleosomes or higher order chromatin structure.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
anaphase-promoting complex
Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein.
cellular_component
APC
A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
PMID:10465783
http://purl.org/obo/owl/PMID#PMID_10465783
PMID:10611969
http://purl.org/obo/owl/PMID#PMID_10611969
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
GOC:jh
http://purl.org/obo/owl/GOC#GOC_jh
cyclosome
anaphase promoting complex
Wikipedia:Anaphase-promoting_complex
http://purl.org/obo/owl/Wikipedia#Wikipedia_Anaphase-promoting_complex
spliceosomal complex
cellular_component
spliceosome
spliceosome complex
Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Wikipedia:Spliceosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Spliceosome
U5 snRNP
cellular_component
A ribonucleoprotein complex that contains small nuclear RNA U5.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
snRNP U5
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
U7 snRNP
cellular_component
A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs.
PMID:12872004
http://purl.org/obo/owl/PMID#PMID_12872004
snRNP U7
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
U2-type spliceosomal complex
A U2-type complex refers to any of the snRNP-based complexes that form during splicing that uses U2 (as opposed to U12). There are complexes that form during U2-splicing that don't necessarily contain the U2 snRNP.
cellular_component
GT-AG spliceosome
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
major spliceosomal complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:11343900
http://purl.org/obo/owl/PMID#PMID_11343900
major (U2-type) spliceosomal complex
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
U1 snRNP
cellular_component
A ribonucleoprotein complex that contains small nuclear RNA U1.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
snRNP U1
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
U2 snRNP
U2 snRNP refers to the U2 small nuclear RNA and the proteins that associate with it. U2 snRNP is not considered to be a type of spliceosomal complex by itself.
cellular_component
snRNP U2
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A ribonucleoprotein complex that contains small nuclear RNA U2.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
17S U2 snRNP
U4 snRNP
cellular_component
A ribonucleoprotein complex that contains small nuclear RNA U4.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
snRNP U4
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
U6 snRNP
cellular_component
snRNP U6
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A ribonucleoprotein complex that contains small nuclear RNA U6.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
U12-type spliceosomal complex
cellular_component
minor (U12-type) spliceosomal complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:11971955
http://purl.org/obo/owl/PMID#PMID_11971955
PMID:11574683
http://purl.org/obo/owl/PMID#PMID_11574683
AT-AC spliceosomal complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
minor spliceosomal complex
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Wikipedia:Minor_spliceosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Minor_spliceosome
U4atac snRNP
cellular_component
snRNP U4atac
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A ribonucleoprotein complex that contains small nuclear RNA U4atac.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
U6atac snRNP
cellular_component
A ribonucleoprotein complex that contains small nuclear RNA U6atac.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
snRNP U6atac
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
U11 snRNP
cellular_component
A ribonucleoprotein complex that contains small nuclear RNA U11.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
12S U11 snRNP
snRNP U11
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
U12 snRNP
cellular_component
snRNP U12
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A ribonucleoprotein complex that contains small nuclear RNA U12.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
chromosome
cellular_component
interphase chromosome
prophase chromosome
Wikipedia:Chromosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Chromosome
chromatid
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
chromatid
This term was made obsolete because it is not a unique subcellular component, i.e. the difference between this term and 'chromosome' is based on temporal and process distinctions.
cellular_component
OBSOLETE. One of the two daughter strands of a duplicated chromosome that become apparent between early prophase and metaphase in mitosis and between diplotene and second metaphase in meiosis.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
telomere
This term was made obsolete because the definition was too sequence oriented and too restrictive.
cellular_component
OBSOLETE. A complex of DNA and protein that seals the end of a chromosome. The telomeric DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA.
PMID:11352055
http://purl.org/obo/owl/PMID#PMID_11352055
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
telomerase holoenzyme complex
cellular_component
Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits.
PMID:11884619
http://purl.org/obo/owl/PMID#PMID_11884619
centromere
This term was made obsolete because it is a genetically defined region and not a specific subcellular localization.
cellular_component
OBSOLETE. The region of a eukaryotic chromosome that is attached to the spindle during nuclear division. It is defined genetically as the region of the chromosome that always segregates at the first division of meiosis; the region of the chromosome in which no crossing over occurs. At the start of M phase, each chromosome consists of two sister chromatids with a constriction at a point which forms the centromere. During late prophase two kinetochores assemble on each centromere, one kinetochore on each sister chromatid.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
polytene chromosome
cellular_component
Wikipedia:Polytene_chromosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Polytene_chromosome
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
polytene chromosome chromocenter
cellular_component
polytene chromosome chromocentre
A region at which the centric regions of polytene chromosomes are joined together.
ISBN:0120649012
http://purl.org/obo/owl/ISBN#ISBN_0120649012
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
polytene chromosome weak point
cellular_component
A region of the polytene chromosome where the diameter is considerably decreased, probably resulting from local differences in chromosome organization.
ISBN:0120649012
http://purl.org/obo/owl/ISBN#ISBN_0120649012
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
constriction
polytene chromosome puff
cellular_component
A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
ISBN:0120649012
http://purl.org/obo/owl/ISBN#ISBN_0120649012
polytene chromosome band
cellular_component
A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band.
PMID:11361342
http://purl.org/obo/owl/PMID#PMID_11361342
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
polytene chromosome interband
cellular_component
A stretch of less tightly packed chromatin along the polytene chromosome, found between bands.
PMID:11361342
http://purl.org/obo/owl/PMID#PMID_11361342
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
polytene chromosome ectopic fiber
cellular_component
polytene chromosome ectopic fibre
A thread-like connection joining two regions of ectopically paired polytene chromosomes.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
ISBN:0120649012
http://purl.org/obo/owl/ISBN#ISBN_0120649012
interphase chromosome
This term was made obsolete because it is based on a temporal division of the cell cycle.
cellular_component
OBSOLETE. A chromosome found in the cell during interphase of the cell cycle. Chromosomes are usually decondensed during interphase and each long DNA molecule in a chromosome is divided into a large number of discrete domains that are folded differently.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
mitotic chromosome
This term was made obsolete because it is based on a process.
cellular_component
OBSOLETE. A chromosome involved in the process of mitosis.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
prophase chromosome
This term was made obsolete because it is based on a temporal division of the cell cycle.
cellular_component
OBSOLETE. A chromosome found in the cell during prophase.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
metaphase chromosome
This term was made obsolete because it is based on a temporal division of the cell cycle.
cellular_component
OBSOLETE. A chromosome found in the cell during metaphase. Typically, sister chromatids are held together at their centromeres and chromosomes are covered with a large number of molecules, including ribonucleoproteins.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
meiotic chromosome
This term was made obsolete because it is based on a process.
cellular_component
OBSOLETE. A chromosome involved in the process of meiosis.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
chiasma
cellular_component
A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
Wikipedia:Chiasma_(genetics)
http://purl.org/obo/owl/Wikipedia#Wikipedia_Chiasma_(genetics)
recombination nodule
cellular_component
An electron dense structure that is associated with meiotic chromosomes.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
early recombination nodule
cellular_component
An electron dense structure that is associated with meiotic chromosomes in leptotene or zygotene during meiosis I.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
late recombination nodule
cellular_component
An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I.
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
nuclear euchromatin
cellular_component
The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
nuclear heterochromatin
cellular_component
A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
centromeric heterochromatin
cellular_component
A region of heterochromatin located near the centromere of a chromosome.
PMID:12019236
http://purl.org/obo/owl/PMID#PMID_12019236
centric heterochromatin
beta-heterochromatin
cellular_component
A diffusely banded region of heterochromatin located between euchromatin and alpha-heterochromatin in the polytene chromosome chromocenter; normally replicated during polytenization.
PMID:11404334
http://purl.org/obo/owl/PMID#PMID_11404334
PMID:8878678
http://purl.org/obo/owl/PMID#PMID_8878678
alpha-heterochromatin
cellular_component
A small, compact region of heterochromatin located in the middle of the polytene chromosome chromocenter, which undergoes little or no replication during polytenization.
PMID:8878678
http://purl.org/obo/owl/PMID#PMID_8878678
nuclear telomeric heterochromatin
cellular_component
Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
intercalary heterochromatin
cellular_component
Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes.
PMID:14579245
http://purl.org/obo/owl/PMID#PMID_14579245
perichromatin fibrils
cellular_component
Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts.
PMID:14731598
http://purl.org/obo/owl/PMID#PMID_14731598
extrachromosomal circular DNA
cellular_component
Circular DNA structures that are not part of a chromosome.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
extrachromosomal rDNA circle
cellular_component
Circular DNA molecules encoding ribosomal RNA that are replicated independently of chromosomal replication. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats.
PMID:12044934
http://purl.org/obo/owl/PMID#PMID_12044934
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
extrachromosomal ribosomal DNA circle
2-micrometer circle DNA
cellular_component
A plasmid commonly found in Saccharomyces, inherited in a non-Mendelian manner and often present in 100-400 copies.
PMID:12073320
http://purl.org/obo/owl/PMID#PMID_12073320
nucleolus
cellular_component
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
NIF_Subcellular:sao1820400233
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1820400233
Wikipedia:Nucleolus
http://purl.org/obo/owl/Wikipedia#Wikipedia_Nucleolus
nucleolus organizer region
cellular_component
Wikipedia:Nucleolus_organizer_region
http://purl.org/obo/owl/Wikipedia#Wikipedia_Nucleolus_organizer_region
nucleolus organizer complex
nucleolus organiser region
NOR
A region of a chromosome where nucleoli form during interphase, and where genes encoding the largest rRNA precursor transcript are tandemly arrayed.
PMID:14504406
http://purl.org/obo/owl/PMID#PMID_14504406
small nucleolar ribonucleoprotein complex
Note that 'nucleolar' in the term name is part of the RNA family designation 'small nucleolar', and does not necessarily reflect the location of the complex.
cellular_component
snoRNP
A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type.
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
small nucleolar ribonucleoprotein
small nucleolar RNA
This term was made obsolete because it represents a gene product.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
snoRNA
box C + D snoRNP protein
This term was made obsolete because it represents a gene product.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
box H + ACA snoRNP protein
This term was made obsolete because it represents a gene product.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
DNA-directed RNA polymerase I complex
cellular_component
DNA-directed RNA polymerase I activity
RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
cytoplasm
cellular_component
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
Wikipedia:Cytoplasm
http://purl.org/obo/owl/Wikipedia#Wikipedia_Cytoplasm
mitochondrion
cellular_component
NIF_Subcellular:sao1860313010
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1860313010
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
Wikipedia:Mitochondrion
http://purl.org/obo/owl/Wikipedia#Wikipedia_Mitochondrion
mitochondria
mitochondrial envelope
cellular_component
The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.
GOC:pz
http://purl.org/obo/owl/GOC#GOC_pz
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
mitochondrial outer membrane
cellular_component
outer mitochondrial membrane
Wikipedia:Outer_mitochondrial_membrane
http://purl.org/obo/owl/Wikipedia#Wikipedia_Outer_mitochondrial_membrane
NIF_Subcellular:sao1289741256
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1289741256
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
mitochondrial outer membrane translocase complex
cellular_component
GIP complex
TOM complex
A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments.
PMID:12581629
http://purl.org/obo/owl/PMID#PMID_12581629
mitochondrial inner membrane
cellular_component
inner mitochondrial membrane
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
Wikipedia:Inner_mitochondrial_membrane
http://purl.org/obo/owl/Wikipedia#Wikipedia_Inner_mitochondrial_membrane
NIF_Subcellular:sao1371347282
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1371347282
mitochondrial inner membrane presequence translocase complex
See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
cellular_component
Tim23 complex
mitochondrial inner membrane translocase complex
mitochondrial inner membrane pre-sequence translocase complex
The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.
EC:3.6.3.51
http://purl.org/obo/owl/EC#EC_3.6.3.51
PMID:8851659
http://purl.org/obo/owl/PMID#PMID_8851659
m-AAA complex
cellular_component
Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria.
PMID:12417197
http://purl.org/obo/owl/PMID#PMID_12417197
PMID:21147776
http://purl.org/obo/owl/PMID#PMID_21147776
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
mitochondrial respiratory chain
cellular_component
mitochondrial electron transport chain
The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
mitochondrial respiratory chain complex I
GO:0005748
cellular_component
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
mitochondrial respiratory chain complex II
GO:0030390
cellular_component
GO:0019738
GO:0009362
GO:0008136
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
mitochondrial fumarate reductase complex
mitochondrial respiratory chain complex III
GO:0015008
cellular_component
mitochondrial electron transport complex III
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
mitochondrial cytochrome bc1 complex
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
mitochondrial cytochrome bc(1) complex
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
mitochondrial ubiquinol-cytochrome-c reductase complex
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
mitochondrial complex III
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
mitochondrial ubiquinol-cytochrome c oxidoreductase complex
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
mitochondrial respiratory chain complex IV
GO:0005752
cellular_component
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
mitochondrial proton-transporting ATP synthase complex
GO:0016470
cellular_component
mitochondrial respiratory chain complex V
A proton-transporting ATP synthase complex found in the mitochondrial membrane.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mitochondrial proton-transporting ATP synthase, catalytic core
cellular_component
The hexamer, comprising three alpha and three beta subunits, that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:10838056
http://purl.org/obo/owl/PMID#PMID_10838056
hydrogen-transporting ATP synthase, coupling factor CF(0)
This term was made obsolete because more specific terms were created.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
mitochondrial proton-transporting ATP synthase, central stalk
cellular_component
One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; rotates within the catalytic core during catalysis.
PMID:10838056
http://purl.org/obo/owl/PMID#PMID_10838056
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
mitochondrial permeability transition pore complex
cellular_component
A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol.
PMID:10393078
http://purl.org/obo/owl/PMID#PMID_10393078
mitochondrial PT pore complex
mitochondrial intermembrane space
cellular_component
GO:0031971
NIF_Subcellular:sao118944228
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao118944228
mitochondrial membrane lumen
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mitochondrial envelope lumen
mitochondrial matrix
cellular_component
GO:0031980
mitochondrial lumen
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
GOC:as
http://purl.org/obo/owl/GOC#GOC_as
mitochondrial stroma
Wikipedia:Mitochondrial_matrix
http://purl.org/obo/owl/Wikipedia#Wikipedia_Mitochondrial_matrix
NIF_Subcellular:sao-1899375636
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao-1899375636
NIF_Subcellular:sao1804523077
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1804523077
gamma DNA polymerase complex
cellular_component
A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA.
PMID:12045093
http://purl.org/obo/owl/PMID#PMID_12045093
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
mitochondrial ribosome
cellular_component
A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
55S ribosome, mitochondrial
mitochondrial large ribosomal subunit
cellular_component
39S ribosomal subunit, mitochondrial
The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
mitochondrial small ribosomal subunit
cellular_component
mitochondrial ribosomal SSU complex
28S ribosomal subunit, mitochondrial
mitochondrial ribosomal small subunit complex
The smaller of the two subunits of a mitochondrial ribosome.
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
lysosome
cellular_component
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
Wikipedia:Lysosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Lysosome
NIF_Subcellular:sao585356902
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao585356902
lysosomal membrane
cellular_component
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
primary lysosome
cellular_component
A lysosome before it has fused with a vesicle or vacuole.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
NIF_Subcellular:sao1140587416
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1140587416
secondary lysosome
cellular_component
Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
NIF_Subcellular:sao1549842807
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1549842807
endosome
cellular_component
Wikipedia:Endosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Endosome
NIF_Subcellular:sao1720343330
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1720343330
A membrane-bounded organelle to which materials ingested by endocytosis are delivered.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
PMID:19696797
http://purl.org/obo/owl/PMID#PMID_19696797
early endosome
cellular_component
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:19696797
http://purl.org/obo/owl/PMID#PMID_19696797
late endosome
cellular_component
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
PMID:2557062
http://purl.org/obo/owl/PMID#PMID_2557062
PMID:11964142
http://purl.org/obo/owl/PMID#PMID_11964142
PVC
prevacuolar compartment
multivesicular body
cellular_component
NIF_Subcellular:sao2045955158
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao2045955158
A type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
PMID:11566881
http://purl.org/obo/owl/PMID#PMID_11566881
multivesicular endosome
PMID:12122203
http://purl.org/obo/owl/PMID#PMID_12122203
MVB
MVE
PMID:12122203
http://purl.org/obo/owl/PMID#PMID_12122203
vacuole
cellular_component
Wikipedia:Vacuole
http://purl.org/obo/owl/Wikipedia#Wikipedia_Vacuole
vacuolar carboxypeptidase Y
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
vacuolar membrane
cellular_component
The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
vacuolar lumen
cellular_component
The volume enclosed within the vacuolar membrane.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
autophagic vacuole
cellular_component
A double-membrane-bounded compartment in which endogenous cellular material is sequestered; known as autophagosome in yeast.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
PMID:11099404
http://purl.org/obo/owl/PMID#PMID_11099404
autophagosome
peroxisome
cellular_component
GO:0019818
peroxisome vesicle
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
UniProtKB-KW:KW-0576
http://purl.org/obo/owl/UniProtKB-KW#UniProtKB-KW_KW-0576
PMID:9302272
http://purl.org/obo/owl/PMID#PMID_9302272
GOC:pm
http://purl.org/obo/owl/GOC#GOC_pm
peroxisomal
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
Wikipedia:Peroxisome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Peroxisome
NIF_Subcellular:sao499555322
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao499555322
peroxisomal membrane
cellular_component
peroxisome membrane
The lipid bilayer surrounding a peroxisome.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
integral to peroxisomal membrane
cellular_component
Penetrating at least one phospholipid bilayer of a peroxisomal membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
extrinsic to intraperoxisomal membrane
cellular_component
Loosely bound to the intraperoxisomal surface of the peroxisomal membrane, but not integrated into the hydrophobic region.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intra-peroxisomal peripheral membrane
peroxisome targeting signal receptor complex
This term was made obsolete because it represents a single polypeptide rather than a complex; all known peroxisome targeting signal receptors are monomeric.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
peroxisomal matrix
GO:0031909
cellular_component
The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
peroxisomal lumen
endoplasmic reticulum
cellular_component
ER
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
Wikipedia:Endoplasmic_reticulum
http://purl.org/obo/owl/Wikipedia#Wikipedia_Endoplasmic_reticulum
NIF_Subcellular:sao1036339110
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1036339110
Sec61 translocon complex
cellular_component
Sec61p-Sbh1p-Sss1p complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events.
PMID:18166647
http://purl.org/obo/owl/PMID#PMID_18166647
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
signal recognition particle receptor complex
cellular_component
SR complex
docking protein complex
A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
signal recognition particle, endoplasmic reticulum targeting
cellular_component
GO:0005855
A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
Wikipedia:Signal_recognition_particle
http://purl.org/obo/owl/Wikipedia#Wikipedia_Signal_recognition_particle
signal sequence receptor complex
SRP
signal peptidase complex
cellular_component
A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space.
GOC:sgd_curators
http://purl.org/obo/owl/GOC#GOC_sgd_curators
PMID:1846444
http://purl.org/obo/owl/PMID#PMID_1846444
PMID:7615509
http://purl.org/obo/owl/PMID#PMID_7615509
endoplasmic reticulum lumen
GO:0016022
cellular_component
endoplasmic reticulum cisterna
cisternal lumen
ER lumen
ER cisterna
The volume enclosed by the membranes of the endoplasmic reticulum.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
endoplasmic reticulum membrane
cellular_component
The lipid bilayer surrounding the endoplasmic reticulum.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ER membrane
smooth endoplasmic reticulum
cellular_component
Wikipedia:Endoplasmic_reticulum#Smooth_endoplasmic_reticulum
http://purl.org/obo/owl/Wikipedia#Wikipedia_Endoplasmic_reticulum#Smooth_endoplasmic_reticulum
smooth ER
NIF_Subcellular:sao710427438
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao710427438
SER
The smooth endoplasmic reticulum (ER) has with no ribosomes attached to it. The smooth is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
rough endoplasmic reticulum
cellular_component
The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
rough ER
Wikipedia:Endoplasmic_reticulum#Rough_endoplasmic_reticulum
http://purl.org/obo/owl/Wikipedia#Wikipedia_Endoplasmic_reticulum#Rough_endoplasmic_reticulum
RER
NIF_Subcellular:sao1881364067
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1881364067
microsome
Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. It is advised that this term should only be used in a manual annotation statement where it is possible to apply an experimental evidence code and only if no other experimental evidence exists for an equivalent in vivo subcellular location.
cellular_component
microsomal membrane
Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic cells are homogenized and that sediment on centrifugation at 100000 g.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
Wikipedia:Microsome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Microsome
endoplasmic reticulum-Golgi intermediate compartment
cellular_component
vesicular-tubular cluster
Wikipedia:Vesicular-tubular_cluster
http://purl.org/obo/owl/Wikipedia#Wikipedia_Vesicular-tubular_cluster
pre-Golgi intermediate compartment
ERGIC
A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport.
GOC:pr
http://purl.org/obo/owl/GOC#GOC_pr
PMID:16723730
http://purl.org/obo/owl/PMID#PMID_16723730
ER-Golgi intermediate compartment
Wikipedia:Vesicular-tubular_cluster
http://purl.org/obo/owl/Wikipedia#Wikipedia_Vesicular-tubular_cluster
Golgi apparatus
Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.
cellular_component
Golgi complex
Wikipedia:Golgi_apparatus
http://purl.org/obo/owl/Wikipedia#Wikipedia_Golgi_apparatus
NIF_Subcellular:sao451912436
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao451912436
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
Golgi ribbon
Golgi
Golgi stack
GO:0016940
cellular_component
The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
Golgi cisternae
dictyosome
Golgi lumen
cellular_component
The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Golgi medial cisterna
cellular_component
The middle Golgi cisterna (or cisternae).
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
Golgi-associated vesicle
Note that this definition includes vesicles that are transiently associated with the Golgi.
cellular_component
Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
NIF_Subcellular:sao819927218
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao819927218
Golgi vesicle
coatomer
This term was made obsolete because its position and synonym implied that it confused a coated vesicle with the coat itself.
cellular_component
COPI vesicle
OBSOLETE (was not defined before being made obsolete).
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
COPII vesicle
This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
cis-Golgi network
The CGN is not considered part of the Golgi apparatus but is a separate organelle.
cellular_component
forming face
Golgi cis face
The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
Golgi cis-face
cis Golgi network
trans-Golgi network
The TGN is not considered part of the Golgi apparatus but is a separate organelle.
cellular_component
Golgi trans face
late Golgi
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Golgi trans-face
The network of interconnected tubular and cisternal structures located at the side of the Golgi apparatus distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
trans Golgi network
maturing face
TGN
NIF_Subcellular:sao9456487
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao9456487
secretory vesicle
This term was made obsolete because it was being used to describe two different components.
cellular_component
transition vesicle
OBSOLETE. A small subcellular vesicle, or granule, surrounded by a single-layered membrane; formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
secretory vesicle membrane
This term was made obsolete because its parent was made obsolete.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
ER-Golgi transport vesicle
This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
Golgi-ER transport vesicle
This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
Golgi-plasma membrane transport vesicle
This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; a personal communication from John Armstrong indicated that a replacement term was not required, as TGN-Golgi transport is likely to be mediated by tubules rather than vesicles.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
Golgi-vacuole transport vesicle
This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
endocytotic transport vesicle
This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
lipid particle
Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers.
cellular_component
adiposome
lipid body
Any particle of coalesced lipids in the cytoplasm of a cell. May include associated proteins.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
lipid droplet
centrosome
cellular_component
Wikipedia:Centrosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Centrosome
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
centriole
cellular_component
A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
NIF_Subcellular:sao95019936
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao95019936
Wikipedia:Centriole
http://purl.org/obo/owl/Wikipedia#Wikipedia_Centriole
microtubule organizing center
cellular_component
A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
PMID:17245416
http://purl.org/obo/owl/PMID#PMID_17245416
microtubule organising centre
Wikipedia:Microtubule_organizing_center
http://purl.org/obo/owl/Wikipedia#Wikipedia_Microtubule_organizing_center
MTOC
spindle pole body
cellular_component
SPB
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome.
ISBN:0879693568
http://purl.org/obo/owl/ISBN#ISBN_0879693568
Wikipedia:Spindle_pole_body
http://purl.org/obo/owl/Wikipedia#Wikipedia_Spindle_pole_body
centrosomal mitotic factor
This term was made obsolete because it was not defined.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
aster
cellular_component
An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores.
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
spindle
cellular_component
Wikipedia:Spindle_apparatus
http://purl.org/obo/owl/Wikipedia#Wikipedia_Spindle_apparatus
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
intermediate layer of spindle pole body
cellular_component
Structure between the central and outer plaques of the spindle pole body.
PMID:9215630
http://purl.org/obo/owl/PMID#PMID_9215630
inner plaque of spindle pole body
cellular_component
One of three laminate structures that form the spindle pole body; the inner plaque is in the nucleus.
ISBN:0879693568
http://purl.org/obo/owl/ISBN#ISBN_0879693568
central plaque of spindle pole body
cellular_component
One of three laminate structures that form the spindle pole body; the central plaque is embedded in the nuclear envelope.
ISBN:0879693568
http://purl.org/obo/owl/ISBN#ISBN_0879693568
outer plaque of spindle pole body
cellular_component
One of three laminate structures that form the spindle pole body; the outer plaque is in the cytoplasm.
ISBN:0879693568
http://purl.org/obo/owl/ISBN#ISBN_0879693568
half bridge of spindle pole body
cellular_component
Structure adjacent to the plaques of the spindle pole body.
ISBN:0879693568
http://purl.org/obo/owl/ISBN#ISBN_0879693568
actomyosin contractile ring
cellular_component
GO:0030480
actomyosin ring
cytokinetic ring
A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells. In animal cells, the contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis.
GOC:sgd_curators
http://purl.org/obo/owl/GOC#GOC_sgd_curators
GOC:expert_jrp
http://purl.org/obo/owl/GOC#GOC_expert_jrp
ISBN:0805319409
http://purl.org/obo/owl/ISBN#ISBN_0805319409
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
constriction ring
contractile actomyosin ring
CAR
polar microtubule
cellular_component
Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
pole-to-pole microtubule
kinetochore microtubule
cellular_component
Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
pole-to-kinetochore microtubule
cytosol
cellular_component
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GOC:hgd
http://purl.org/obo/owl/GOC#GOC_hgd
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
NIF_Subcellular:sao101633890
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao101633890
Wikipedia:Cytosol
http://purl.org/obo/owl/Wikipedia#Wikipedia_Cytosol
steroid hormone aporeceptor complex
cellular_component
A protein complex consisting of a steroid receptor associated with nonreceptor proteins, minimally a dimer of Hsp90 and a monomer of hsp56/FKBP59; forms in the absence of bound ligand.
PMID:7493981
http://purl.org/obo/owl/PMID#PMID_7493981
chaperonin-containing T-complex
cellular_component
A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.
PMID:11580267
http://purl.org/obo/owl/PMID#PMID_11580267
GOC:sgd_curators
http://purl.org/obo/owl/GOC#GOC_sgd_curators
TriC
CCT particle
hemoglobin complex
cellular_component
An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
haemoglobin complex
heterotrimeric G-protein complex
See also the molecular function term 'G-protein coupled receptor activity ; GO:0004930'.
cellular_component
heterotrimeric G-protein GTPase, beta-subunit
heterotrimeric G-protein GTPase, alpha-subunit
heterotrimeric G-protein GTPase activity
heterotrimeric G-protein GTPase, gamma-subunit
Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
fatty acid synthase complex
cellular_component
GO:0031374
GO:0031373
cytosolic fatty acid synthase complex
cytosolic type I FAS complex
cytosolic type I fatty acid synthase complex
FAS complex
Wikipedia:Fatty_acid_synthetase_complex
http://purl.org/obo/owl/Wikipedia#Wikipedia_Fatty_acid_synthetase_complex
cytosolic FAS complex
A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA.
GOC:sgd_curators
http://purl.org/obo/owl/GOC#GOC_sgd_curators
GOC:pde
http://purl.org/obo/owl/GOC#GOC_pde
ISBN:0716746840
http://purl.org/obo/owl/ISBN#ISBN_0716746840
holo-[acyl-carrier-protein] synthase complex
fatty acid synthetase complex
fatty-acyl-CoA synthase complex
Note that fatty acid synthetases of vertebrates and yeast are stable enzyme complexes of multifunctional polypeptide chains, whereas the fatty acid synthetases of plants and E. coli consist of non-associated individual enzymes.
cellular_component
A protein complex that possesses fatty-acyl-CoA synthase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
BRENDA:2.3.1.86
http://purl.org/obo/owl/BRENDA#BRENDA_2.3.1.86
fatty acyl CoA synthase complex
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
26S proteasome
This term was made obsolete because its definition was inaccurate.
cellular_component
OBSOLETE. A large multisubunit protease found in the cytosol that recognizes, unfolds, and digests protein substrates that have been marked for degradation by the attachment of a ubiquitin group. Individual subcomplexes of the complete 26S proteasome are involved in these different tasks: the ATP-dependent 19S caps are believed to unfold substrates and feed them to the actual protease, the 20S proteasome.
PMID:10410804
http://purl.org/obo/owl/PMID#PMID_10410804
proteasome regulatory particle
cellular_component
PA700 proteasome activator
modulator complex
CORUM:28
http://purl.org/obo/owl/CORUM#CORUM_28
A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex.
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
19S regulatory particle
PA700-dependent proteasome activator
CORUM:28
http://purl.org/obo/owl/CORUM#CORUM_28
proteasome core complex
GO:0000503
cellular_component
macropain
20S proteasome
GOC:cjk
http://purl.org/obo/owl/GOC#GOC_cjk
20S core complex
PA28gamma-20S proteasome
CORUM:194
http://purl.org/obo/owl/CORUM#CORUM_194
A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex.
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
PMID:10806206
http://purl.org/obo/owl/PMID#PMID_10806206
ribosome
GO:0033279
cellular_component
An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
Wikipedia:Ribosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Ribosome
NIF_Subcellular:sao1429207766
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1429207766
ribosomal RNA
polysome
cellular_component
polyribosome
Wikipedia:Polysome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Polysome
Several ribosomes bound to one mRNA.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
mRNA cap binding complex
cellular_component
mRNA cap complex
Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA.
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
nuclear cap binding complex
Note that this complex can be found in the cytoplasm as well as the nucleus.
cellular_component
A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export.
PMID:16043498
http://purl.org/obo/owl/PMID#PMID_16043498
NCBP-NIP1 complex
mRNA cap binding complex
CBC
snRNA cap binding complex
mRNA cleavage and polyadenylation specificity factor complex
cellular_component
A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal.
PMID:14749727
http://purl.org/obo/owl/PMID#PMID_14749727
cleavage and polyadenylylation specificity factor activity
CFII complex
CPSF complex
CPF complex
mRNA cleavage stimulating factor complex
cellular_component
cleavage stimulation factor activity
A protein complex required for mRNA cleavage but not for poly(A) addition.
PMID:10357856
http://purl.org/obo/owl/PMID#PMID_10357856
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
CstF complex
mRNA cleavage factor complex
cellular_component
Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:10357856
http://purl.org/obo/owl/PMID#PMID_10357856
eukaryotic translation initiation factor 2 complex
cellular_component
eIF2
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
eIF-2
Wikipedia:EIF-2
http://purl.org/obo/owl/Wikipedia#Wikipedia_EIF-2
Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA.
PMID:10216940
http://purl.org/obo/owl/PMID#PMID_10216940
eukaryotic translation initiation factor 2B complex
cellular_component
eIF-2B
eif2B
A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.
PMID:9438375
http://purl.org/obo/owl/PMID#PMID_9438375
eukaryotic translation initiation factor 3 complex
cellular_component
A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.
PMID:15904532
http://purl.org/obo/owl/PMID#PMID_15904532
eIF3
eIF-3
eukaryotic translation elongation factor 1 complex
cellular_component
A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:10216950
http://purl.org/obo/owl/PMID#PMID_10216950
nascent polypeptide-associated complex
cellular_component
A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome.
PMID:7568149
http://purl.org/obo/owl/PMID#PMID_7568149
PMID:12475173
http://purl.org/obo/owl/PMID#PMID_12475173
NAC
NACA
cytoskeleton
cellular_component
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:16959967
http://purl.org/obo/owl/PMID#PMID_16959967
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
Wikipedia:Cytoskeleton
http://purl.org/obo/owl/Wikipedia#Wikipedia_Cytoskeleton
axonemal dynein complex
cellular_component
A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. May contain two or three dynein heavy chains as well as several light chains.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
axonemal dynein intermediate chain
axonemal dynein heavy chain
axonemal dynein intermediate light chain
axonemal dynein light chain
muscle myosin complex
cellular_component
A filament of myosin found in a muscle cell of any type.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
troponin complex
cellular_component
A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
muscle thin filament tropomyosin
cellular_component
A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
striated muscle myosin thick filament
cellular_component
Bipolar filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
GOC:mtg_muscle
http://purl.org/obo/owl/GOC#GOC_mtg_muscle
striated muscle thin filament
cellular_component
Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
cytoplasmic dynein complex
cellular_component
Any dynein complex that catalyzes movement along a cytoplasmic microtubule; cytoplasmic dynein complexes participates in many transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes,and may include light chains and light intermediate chains.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:12600311
http://purl.org/obo/owl/PMID#PMID_12600311
cytoplasmic dynein light chain
cytoplasmic dynein heavy chain
cytoplasmic dynein intermediate chain
cytoplasmic dynein intermediate light chain
dynactin complex
cellular_component
A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
actin capping protein of dynactin complex
cellular_component
A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, nucleates the polymerization of actin monomers but does not sever actin filaments, and which is a part of the dynactin complex.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:18221362
http://purl.org/obo/owl/PMID#PMID_18221362
PMID:18544499
http://purl.org/obo/owl/PMID#PMID_18544499
kinesin complex
cellular_component
Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
URL:http://www.proweb.org/kinesin//KinesinMotility.html
http://www.proweb.org/kinesin//KinesinMotility.html
URL:http://www.proweb.org/kinesin//KinesinStructure.html
http://www.proweb.org/kinesin//KinesinStructure.html
minus-end kinesin complex
cellular_component
Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the minus end of a microtubule.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
plus-end kinesin complex
cellular_component
Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the plus end of a microtubule.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
microtubule
cellular_component
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
ISBN:0879693568
http://purl.org/obo/owl/ISBN#ISBN_0879693568
Wikipedia:Microtubule
http://purl.org/obo/owl/Wikipedia#Wikipedia_Microtubule
NIF_Subcellular:sao1846835077
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1846835077
microtubuli
microtubulus
microtubule associated complex
cellular_component
Any multimeric complex connected to a microtubule.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
spindle microtubule
cellular_component
Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
axonemal microtubule
cellular_component
A microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
nuclear microtubule
cellular_component
Any microtubule in the nucleus of a cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cytoplasmic microtubule
cellular_component
Any microtubule in the cytoplasm of a cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
non-spindle-associated astral microtubule
intermediate filament
cellular_component
type I intermediate filament associated protein
Wikipedia:Intermediate_filament
http://purl.org/obo/owl/Wikipedia#Wikipedia_Intermediate_filament
NIF_Subcellular:sao952483289
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao952483289
intermediate filament associated protein
type II intermediate filament associated protein
A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins.
URL:http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm
http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
neurofilament
cellular_component
NIF_Subcellular:sao1316272517
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1316272517
Wikipedia:Neurofilament
http://purl.org/obo/owl/Wikipedia#Wikipedia_Neurofilament
A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter.
ISBN:0716731363
http://purl.org/obo/owl/ISBN#ISBN_0716731363
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
type IV intermediate filament
actin filament
cellular_component
A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:10666339
http://purl.org/obo/owl/PMID#PMID_10666339
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
Wikipedia:Actin
http://purl.org/obo/owl/Wikipedia#Wikipedia_Actin
NIF_Subcellular:sao1588493326
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1588493326
microfilament
Arp2/3 protein complex
cellular_component
A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:12479800
http://purl.org/obo/owl/PMID#PMID_12479800
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
plasma membrane
GO:0005904
cellular_component
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
ISBN:0716731363
http://purl.org/obo/owl/ISBN#ISBN_0716731363
Wikipedia:Cell_membrane
http://purl.org/obo/owl/Wikipedia#Wikipedia_Cell_membrane
NIF_Subcellular:sao1663586795
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1663586795
juxtamembrane
plasmalemma
plasma membrane lipid bilayer
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
inner endospore membrane
cell membrane
cytoplasmic membrane
bacterial inner membrane
integral to plasma membrane
cellular_component
Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
proteoglycan integral to plasma membrane
This term was made obsolete because it describes the composition (i.e. proteoglycan) and not the location of a gene product.
cellular_component
OBSOLETE. Penetrating at least one phospholipid bilayer of a plasma membrane and consisting of proteoglycan. Also refers to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
hydrogen:potassium-exchanging ATPase complex
cellular_component
proton pump
hydrogen/potassium-exchanging ATPase complex
A protein complex that possesses hydrogen:potassium-exchanging ATPase activity; characterized in animal cells, where it maintains ionic gradients of Na+ and K+ at the expense of ATP hydrolysis; The complex contains two obligatory subunits, the catalytic alpha subunit and a glycosylated beta subunit; two additional subunits, gamma and channel-inducing factor (CHIF), may also be present.
PMID:11756431
http://purl.org/obo/owl/PMID#PMID_11756431
sodium:potassium-exchanging ATPase complex
cellular_component
Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
sodium/potassium-exchanging ATPase complex
sodium pump
voltage-gated calcium channel complex
cellular_component
voltage-sensitive calcium channel complex
voltage-dependent calcium channel complex
voltage gated calcium channel complex
A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
acetylcholine-gated channel complex
cellular_component
nicotinic acetylcholine receptor
nicotinic acetylcholine-gated receptor-channel complex
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.
PMID:15579462
http://purl.org/obo/owl/PMID#PMID_15579462
PMID:12381728
http://purl.org/obo/owl/PMID#PMID_12381728
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
interleukin-2 receptor complex
cellular_component
IL-2 receptor complex
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A protein complex that binds interleukin-2; comprises alpha, beta, and gamma subunits.
PMID:8266078
http://purl.org/obo/owl/PMID#PMID_8266078
PMID:3116143
http://purl.org/obo/owl/PMID#PMID_3116143
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
interleukin-3 receptor complex
cellular_component
A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-3 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-5.
PMID:11839579
http://purl.org/obo/owl/PMID#PMID_11839579
IL-3 receptor complex
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
interleukin-5 receptor complex
cellular_component
IL-5 receptor complex
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-5 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-3.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:11312115
http://purl.org/obo/owl/PMID#PMID_11312115
PMID:11839579
http://purl.org/obo/owl/PMID#PMID_11839579
interleukin-6 receptor complex
cellular_component
A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130.
PMID:8083235
http://purl.org/obo/owl/PMID#PMID_8083235
IL-6 receptor complex
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
interleukin-9 receptor complex
cellular_component
A protein complex that binds interleukin-9; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-9 receptor, whereas the beta chain is shared with the receptors for several other interleukins.
PMID:10642536
http://purl.org/obo/owl/PMID#PMID_10642536
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
IL-9 receptor complex
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
interleukin-13 receptor complex
cellular_component
IL-13 receptor complex
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A protein complex that binds interleukin-13; consists of two chains, interleukin-13 receptor alpha1 chain and interleukin-4 receptor alpha chain.
PMID:9013879
http://purl.org/obo/owl/PMID#PMID_9013879
PMID:8552669
http://purl.org/obo/owl/PMID#PMID_8552669
insulin receptor complex
cellular_component
A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
oncostatin-M receptor complex
cellular_component
A heterodimeric receptor for the cytokine oncostatin-M (OSM). In humans the receptor complex is made up of the gene products gp130 and OSMR-beta.
PMID:8999038
http://purl.org/obo/owl/PMID#PMID_8999038
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
caveola
cellular_component
GO:0016599
caveolar membrane
caveolae
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include any of the minute pits or incuppings of the cell membrane formed during pinocytosis. Such caveolae may be pinched off to form free vesicles within the cytoplasm.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0721662544
http://purl.org/obo/owl/ISBN#ISBN_0721662544
PMID:16645198
http://purl.org/obo/owl/PMID#PMID_16645198
Wikipedia:Caveolae
http://purl.org/obo/owl/Wikipedia#Wikipedia_Caveolae
microvillus
Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta.
cellular_component
Wikipedia:Microvillus
http://purl.org/obo/owl/Wikipedia#Wikipedia_Microvillus
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
ISBN:0813516194
http://purl.org/obo/owl/ISBN#ISBN_0813516194
brush border
cellular_component
Wikipedia:Brush_border
http://purl.org/obo/owl/Wikipedia#Wikipedia_Brush_border
Dense covering of microvilli on the apical surface of epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
GOC:sl
http://purl.org/obo/owl/GOC#GOC_sl
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
coated pit
cellular_component
A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
PMID:10559856
http://purl.org/obo/owl/PMID#PMID_10559856
PMID:17284835
http://purl.org/obo/owl/PMID#PMID_17284835
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
clathrin adaptor
This term was made obsolete because it was positioned incorrectly, so the replacement term has a definition different from what this term appeared to mean.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
adaptin
HA1 clathrin adaptor
This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
AP1
HA2 clathrin adaptor
This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous.
cellular_component
AP2
OBSOLETE (was not defined before being made obsolete).
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
cell-cell junction
cellular_component
NIF_Subcellular:sao1922892319
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1922892319
intercellular junction
A cell junction that forms a connection between two cells; excludes direct cytoplasmic junctions such as ring canals.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:hb
http://purl.org/obo/owl/GOC#GOC_hb
GOC:dgh
http://purl.org/obo/owl/GOC#GOC_dgh
adherens junction
cellular_component
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
URL:http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html
http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html
cell-cell adherens junction
cellular_component
An adherens junction which connects two cells to each other.
GOC:hb
http://purl.org/obo/owl/GOC#GOC_hb
spot adherens junction
cellular_component
punctum adherens
A small junction assembled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens.
PMID:11700298
http://purl.org/obo/owl/PMID#PMID_11700298
dense plaque
zonula adherens
cellular_component
A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.
ISBN:0815316208
http://purl.org/obo/owl/ISBN#ISBN_0815316208
adhesion belt
NIF_Subcellular:sao1400623473
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1400623473
intermediate junction
zonula adhaerens
belt desmosome
fascia adhaerens
fascia adherens
cellular_component
A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighboring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes.
PMID:11732910
http://purl.org/obo/owl/PMID#PMID_11732910
GOC:mtg_muscle
http://purl.org/obo/owl/GOC#GOC_mtg_muscle
Wikipedia:Fascia_adherens
http://purl.org/obo/owl/Wikipedia#Wikipedia_Fascia_adherens
nephrocyte diaphragm
cellular_component
nephrocyte junction
PMID:8314002
http://purl.org/obo/owl/PMID#PMID_8314002
A specialized cell-cell junction found between nephrocytes of the insect kidney, which is adapted for filtration of hemolymph. The insect nephrocyte is anatomically and functionally similarity to the glomerular podocyte of vertebrates.
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
PMID:18971929
http://purl.org/obo/owl/PMID#PMID_18971929
GOC:mtg_kidney_jan10
http://purl.org/obo/owl/GOC#GOC_mtg_kidney_jan10
septate junction
cellular_component
septate desmosome
NIF_Subcellular:sao427941916
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao427941916
A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates.
ISBN:0815332181
http://purl.org/obo/owl/ISBN#ISBN_0815332181
PMID:11700298
http://purl.org/obo/owl/PMID#PMID_11700298
pleated septate junction
cellular_component
pleated desmosome
A septate junction in which regular arrays of electron-dense septae span the intermembrane space.
PMID:11700298
http://purl.org/obo/owl/PMID#PMID_11700298
smooth septate junction
cellular_component
A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions.
PMID:11700298
http://purl.org/obo/owl/PMID#PMID_11700298
zonula continua
gap junction
cellular_component
Wikipedia:Gap_junction
http://purl.org/obo/owl/Wikipedia#Wikipedia_Gap_junction
NIF_Subcellular:sao118541872
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao118541872
communicating junction
macula communicans
zonula communicans
A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
URL:http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html
http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html
GOC:mtg_muscle
http://purl.org/obo/owl/GOC#GOC_mtg_muscle
ISBN:0815332181
http://purl.org/obo/owl/ISBN#ISBN_0815332181
connexon complex
cellular_component
NIF_Subcellular:sao445019788
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao445019788
An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction.
PMID:11146276
http://purl.org/obo/owl/PMID#PMID_11146276
tight junction
cellular_component
Wikipedia:Tight_junction
http://purl.org/obo/owl/Wikipedia#Wikipedia_Tight_junction
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
ISBN:0815332181
http://purl.org/obo/owl/ISBN#ISBN_0815332181
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
NIF_Subcellular:sao1939999134
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1939999134
zonula occludens
cell-substrate adherens junction
cellular_component
An adherens junction which connects a cell to the extracellular matrix.
GOC:hb
http://purl.org/obo/owl/GOC#GOC_hb
hemi-adherens junction
focal adhesion
GO:0008357
cellular_component
hemi-adherens junction
focal contact
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
ISBN:0124325653
http://purl.org/obo/owl/ISBN#ISBN_0124325653
ISBN:0815316208
http://purl.org/obo/owl/ISBN#ISBN_0815316208
Wikipedia:Focal_adhesion
http://purl.org/obo/owl/Wikipedia#Wikipedia_Focal_adhesion
connecting hemi-adherens junction
cellular_component
A cell-substrate adherens junction, also known as a hemiadherens junction (HAJ) that forms one of a pair of junctions in opposing cells that are separated by only 30-40nm, with a thin line of extracellular electron-dense material in between; found where muscles attach to epidermal cells directly (in insects).
URL:http://flybase.bio.indiana.edu/allied-data/lk/interactive-fly/aignfam/junction.htm
http://flybase.bio.indiana.edu/allied-data/lk/interactive-fly/aignfam/junction.htm
muscle tendon junction
cellular_component
A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons.
GOC:mtg_muscle
http://purl.org/obo/owl/GOC#GOC_mtg_muscle
PMID:12842007
http://purl.org/obo/owl/PMID#PMID_12842007
myotendinous junction
apical hemi-adherens junction
cellular_component
A cell-substrate adherens junction found in the apical region of a cell, such as those found in cuticle-secreting epithelia, which connect the apical membrane to the cuticle.
PMID:11700298
http://purl.org/obo/owl/PMID#PMID_11700298
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
apical dense plaque
apical cell-substrate adherens junction
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cilium
cellular_component
NIF_Subcellular:sao787716553
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao787716553
Wikipedia:Cilium
http://purl.org/obo/owl/Wikipedia#Wikipedia_Cilium
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
axoneme
cellular_component
Wikipedia:Axoneme
http://purl.org/obo/owl/Wikipedia#Wikipedia_Axoneme
The bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
nexin complex
cellular_component
A protein complex found in the axoneme of eukaryotic cilia and flagella. It forms interconnections between the microtubule outer doublets that surround the inner central pair of microtubules.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
microtubule basal body
cellular_component
A short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium or flagellum that is similar in structure to a centriole. The basal body serves as a nucleation site for axoneme growth.
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
NIF_Subcellular:sao11978067
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao11978067
cellular bud
cellular_component
A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated.
GOC:sgd_curators
http://purl.org/obo/owl/GOC#GOC_sgd_curators
cellular bud tip
cellular_component
The end of a cellular bud distal to the site of attachment to the mother cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cellular bud neck
cellular_component
The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
shmoo
This term was made obsolete because it represents a type of whole cell rather than a cellular component. To update annotations, consider the external ontology term 'shmoo ; FAO:0001023'.
cellular_component
OBSOLETE. The characteristic projection formed in response to mating pheromone by cells of Saccharomyces and other fungi with similar life cycles. Named after the Al Capp cartoon character, whose shape it resembles.
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mating projection
cellular_component
The projection formed by unicellular fungi in response to mating pheromone.
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
conjugation tube
shmoo
cell cortex
cellular_component
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
peripheral cytoplasm
Wikipedia:Cell_cortex
http://purl.org/obo/owl/Wikipedia#Wikipedia_Cell_cortex
cell periphery
septin ring
cellular_component
GO:0030481
Wikipedia:Septin_ring
http://purl.org/obo/owl/Wikipedia#Wikipedia_Septin_ring
A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form.
PMID:16009555
http://purl.org/obo/owl/PMID#PMID_16009555
PMID:16151244
http://purl.org/obo/owl/PMID#PMID_16151244
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
unlocalized protein complex
This term was made obsolete because it was originally intended only as a temporary parent for protein complex terms for which no more specific parents had been found. This term no longer has any children: All protein complex terms are is_a 'protein complex ; GO:0043234' and nearly all have been placed under parents to yield more specific paths traversing a part_of relationship. In other words, the term has been superseded by other terms and relationships in the cellular component ontology, and is no longer needed.
cellular_component
OBSOLETE. Used as a holding place for cellular components whose precise localization is, as yet, unknown, or has not been determined by GO (the latter is the major reason for nodes to have this parent); this term should not be used for annotation of gene products.
GOC:ma
http://purl.org/obo/owl/GOC#GOC_ma
phosphatidylinositol 3-kinase complex
cellular_component
1-phosphatidylinositol 3-kinase complex
PIK3C3-PIK3R4 complex
CORUM:429
http://purl.org/obo/owl/CORUM#CORUM_429
PIK3CA-PIK3R1 complex
CORUM:439
http://purl.org/obo/owl/CORUM#CORUM_439
PI3-kinase p85-subunit alpha- PI3-kinase p110 complex
CORUM:2575
http://purl.org/obo/owl/CORUM#CORUM_2575
phosphoinositide 3-kinase complex
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphatidylinositol 3-kinase (PI3K).
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
PI3K complex
1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex
GO:0035030
cellular_component
1-phosphatidylinositol-4-phosphate kinase, class IA complex
A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IA phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways.
PMID:9759495
http://purl.org/obo/owl/PMID#PMID_9759495
PMID:9255069
http://purl.org/obo/owl/PMID#PMID_9255069
class IA PI3K complex
phosphoinositide 3-kinase complex, class IA
1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
GO:0035031
cellular_component
1-phosphatidylinositol-4-phosphate kinase, class IB complex
class IB PI3K complex
A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IB phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks.
PMID:9255069
http://purl.org/obo/owl/PMID#PMID_9255069
PMID:9759495
http://purl.org/obo/owl/PMID#PMID_9759495
phosphoinositide 3-kinase complex, class IB
6-phosphofructokinase complex
cellular_component
A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
See also the molecular function term 'alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity ; GO:0003825'.
cellular_component
A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present.
PMID:9837904
http://purl.org/obo/owl/PMID#PMID_9837904
UDP-glucose-glucosephosphate glucosyltransferase complex
trehalose-6-phosphate synthase/phosphatase
trehalose-6-phosphate synthase complex
mitochondrial alpha-ketoglutarate dehydrogenase complex
cellular_component
2-oxoglutarate dehydrogenase complex
Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
acetolactate synthase complex
See also the molecular function term 'acetolactate synthase activity ; GO:0003984'.
cellular_component
acetohydroxyacid synthase complex
A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate.
PMID:16458324
http://purl.org/obo/owl/PMID#PMID_16458324
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:8756689
http://purl.org/obo/owl/PMID#PMID_8756689
BRENDA:2.2.1.6
http://purl.org/obo/owl/BRENDA#BRENDA_2.2.1.6
aminoadipate-semialdehyde dehydrogenase complex
This term was made obsolete because the catalytic activity resides in a single polypeptide that is not part of a complex with other gene products.
cellular_component
OBSOLETE. A heterodimeric enzyme composed of an alpha and beta subunit. Catalyzes the formation of L-2-aminoadipate from L-2-aminoadipate 6-semialdehyde.
EC:1.2.1.31
http://purl.org/obo/owl/EC#EC_1.2.1.31
anthranilate synthase complex
cellular_component
A heterotetrameric enzyme complex made up of two components I and two components II. Catalyzes the formation of anthranilate, pyruvate and L-glutamate from chorismate and L-glutamine.
MetaCyc:ANTHRANSYN-CPLX
http://purl.org/obo/owl/MetaCyc#MetaCyc_ANTHRANSYN-CPLX
PMID:4886290
http://purl.org/obo/owl/PMID#PMID_4886290
EC:4.1.3.27
http://purl.org/obo/owl/EC#EC_4.1.3.27
carbamoyl-phosphate synthase complex
Note that in higher eukaryotes, carbamoyl-phosphate synthase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term.
cellular_component
carbamoyl-phosphate synthase arginine-specific complex
A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events.
PMID:8626695
http://purl.org/obo/owl/PMID#PMID_8626695
arginine-specific carbamoyl phosphate synthetase complex
carbamoyl phosphate synthase complex
cAMP-dependent protein kinase complex
cellular_component
An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
EC:2.7.11.11
http://purl.org/obo/owl/EC#EC_2.7.11.11
adenosine 3',5'-cyclophosphate-dependent protein kinase complex
cyclic AMP-dependent protein kinase complex
3',5' cAMP-dependent protein kinase complex
3',5'-cAMP-dependent protein kinase complex
PKA
CAAX-protein geranylgeranyltransferase complex
cellular_component
A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane.
PMID:9781874
http://purl.org/obo/owl/PMID#PMID_9781874
calcium- and calmodulin-dependent protein kinase complex
cellular_component
CaMKII
calcium/calmodulin-dependent protein kinase complex
An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins.
EC:2.7.11.17
http://purl.org/obo/owl/EC#EC_2.7.11.17
CAMK2
calcineurin complex
cellular_component
A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin.
ISBN:019859951
http://purl.org/obo/owl/ISBN#ISBN_019859951
calcium-dependent protein serine/threonine phosphatase complex
protein phosphatase type 2B complex
protein kinase CK2 complex
Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex.
cellular_component
casein kinase II complex
A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:10994779
http://purl.org/obo/owl/PMID#PMID_10994779
debranching enzyme
This term was made obsolete because it is ambiguous (there are several debranching enzymes) and because it probably represents the glycogen debranching enzyme which is a single gene product and not a complex.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
DNA-dependent protein kinase-DNA ligase 4 complex
GO:0005959
cellular_component
A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:10854421
http://purl.org/obo/owl/PMID#PMID_10854421
PMID:12235392
http://purl.org/obo/owl/PMID#PMID_12235392
PMID:17072889
http://purl.org/obo/owl/PMID#PMID_17072889
glycine cleavage complex
cellular_component
GO:0070015
GO:0005961
glycine cleavage system
glycine synthase complex
glycine dehydrogenase complex (decarboxylating)
glycine dehydrogenase (decarboxylating) complex
glycine decarboxylase complex
Wikipedia:Glycine_decarboxylase_complex
http://purl.org/obo/owl/Wikipedia#Wikipedia_Glycine_decarboxylase_complex
A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T.
MetaCyc:GCVMULTI-CPLX
http://purl.org/obo/owl/MetaCyc#MetaCyc_GCVMULTI-CPLX
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mitochondrial isocitrate dehydrogenase complex (NAD+)
Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'isocitrate dehydrogenase (NAD+) activity ; GO:0004449'.
cellular_component
Mitochondrial complex that possesses isocitrate dehydrogenase (NAD+) activity.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
magnesium-dependent protein serine/threonine phosphatase complex
cellular_component
An enzyme complex that catalyzes the removal of serine- or threonine-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase.
EC:3.1.3.16
http://purl.org/obo/owl/EC#EC_3.1.3.16
phosphorylase kinase complex
cellular_component
An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a.
EC:2.7.11.19
http://purl.org/obo/owl/EC#EC_2.7.11.19
protein farnesyltransferase complex
cellular_component
A protein complex that possesses protein farnesyltransferase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cyclic-nucleotide phosphodiesterase complex
cellular_component
An enzyme complex that catalyzes the hydrolysis of bonds in a cyclic nucleotide.
EC:3.1.4.-
http://purl.org/obo/owl/EC#EC_3.1.4.-
photoreceptor cyclic-nucleotide phosphodiesterase complex
mitochondrial pyruvate dehydrogenase complex
Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
cellular_component
pyruvate dehydrogenase complex (lipoamide)
Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
ISBN:0471331309
http://purl.org/obo/owl/ISBN#ISBN_0471331309
ISBN:0716720094
http://purl.org/obo/owl/ISBN#ISBN_0716720094
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
Rab-protein geranylgeranyltransferase complex
cellular_component
A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein.
PMID:11886217
http://purl.org/obo/owl/PMID#PMID_11886217
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
GGTase-II complex
RAB-protein geranylgeranyltransferase complex
Rab geranylgeranyltransferase complex
RabGGTase complex
serine-pyruvate aminotransferase complex
cellular_component
GO:0005970
serine-pyruvate aminotransferase, type 2B complex
serine-pyruvate aminotransferase, type 1 complex
An enzyme complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate.
EC:2.6.1.51
http://purl.org/obo/owl/EC#EC_2.6.1.51
ribonucleoside-diphosphate reductase complex
cellular_component
RNR complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ribonucleotide reductase complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor.
BRENDA:1.17.4.1
http://purl.org/obo/owl/BRENDA#BRENDA_1.17.4.1
fibrinogen alpha chain
This term was made obsolete because it represents a single gene product and not a complex.
GO:0008005
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
fibrinogen beta chain
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
GO:0008006
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
fibrinogen gamma chain
This term was made obsolete because it represents a single gene product and not a complex.
GO:0008007
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
lamina lucida
cellular_component
The electron-lucent layer of the basal lamina adjacent to the basal plasma membrane of the cells that rest on the lamina.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
Wikipedia:Lamina_lucida
http://purl.org/obo/owl/Wikipedia#Wikipedia_Lamina_lucida
lamina densa
cellular_component
Wikipedia:Lamina_densa
http://purl.org/obo/owl/Wikipedia#Wikipedia_Lamina_densa
The electron-dense layer of the basal lamina; lies just below the lamina lucida.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
lamina reticularis
cellular_component
A layer of the basal lamina that contains collagen fibrils and connects the basal lamina to the underlying connective tissue.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
membrane attack complex protein beta2 chain
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
synaptic vesicle
cellular_component
NIF_Subcellular:sao1071221672
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1071221672
Wikipedia:Synaptic_vesicle
http://purl.org/obo/owl/Wikipedia#Wikipedia_Synaptic_vesicle
A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and is secreted these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
PMID:10099709
http://purl.org/obo/owl/PMID#PMID_10099709
transcription elongation factor complex
cellular_component
Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
positive transcription elongation factor complex b
See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'.
cellular_component
P-TEFb
PMID:7759473
http://purl.org/obo/owl/PMID#PMID_7759473
A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains cyclin T and a cyclin-dependent protein kinase catalytic subunit.
PMID:7759473
http://purl.org/obo/owl/PMID#PMID_7759473
PMID:19328067
http://purl.org/obo/owl/PMID#PMID_19328067
PMID:10766736
http://purl.org/obo/owl/PMID#PMID_10766736
PMID:17079683
http://purl.org/obo/owl/PMID#PMID_17079683
PMID:16721054
http://purl.org/obo/owl/PMID#PMID_16721054
intracellular ferritin complex
cellular_component
A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains.
PMID:19154717
http://purl.org/obo/owl/PMID#PMID_19154717
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
farnesyl-diphosphate farnesyl transferase complex
This term was made obsolete because there is no evidence that this enzyme ever exists as anything other than a monomer.
cellular_component
OBSOLETE. A complex that possesses farnesyl-diphosphate farnesyl transferase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
guanylate cyclase complex, soluble
See also the molecular function term 'guanylate cyclase activity ; GO:0004383'.
cellular_component
Complex that possesses guanylate cyclase activity and is not bound to a membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
voltage-gated potassium channel complex
cellular_component
voltage gated potassium channel complex
NIF_Subcellular:sao371494298
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao371494298
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
voltage-dependent potassium channel complex
voltage-sensitive potassium channel complex
light-activated voltage-gated calcium channel complex
cellular_component
light-activated voltage gated calcium channel complex
light-activated voltage-dependent calcium channel complex
light-activated voltage-sensitive calcium channel complex
A protein complex that forms a transmembrane channel through which calcium ions may cross a cell membrane in response to changes in membrane potential generated in response to a light stimulus.
PMID:9223679
http://purl.org/obo/owl/PMID#PMID_9223679
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
spectrin
cellular_component
Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins.
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
NIF_Subcellular:sao536287099
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao536287099
Wikipedia:Spectrin
http://purl.org/obo/owl/Wikipedia#Wikipedia_Spectrin
signalosome
cellular_component
CSN
COP9 complex
A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
PMID:11019806
http://purl.org/obo/owl/PMID#PMID_11019806
PMID:14570571
http://purl.org/obo/owl/PMID#PMID_14570571
PMID:12186635
http://purl.org/obo/owl/PMID#PMID_12186635
ecdysone receptor holocomplex
cellular_component
A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
PMID:14592980
http://purl.org/obo/owl/PMID#PMID_14592980
repressor ecdysone receptor complex
cellular_component
A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes.
PMID:10488333
http://purl.org/obo/owl/PMID#PMID_10488333
repressor ecdysone receptor holocomplex
activator ecdysone receptor complex
cellular_component
A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes.
PMID:10488333
http://purl.org/obo/owl/PMID#PMID_10488333
activator ecdysone receptor holocomplex
lysosomal membrane hydrogen-transporting ATPase
This term was made obsolete because more specific terms were created.
cellular_component
V-ATPase
OBSOLETE (was not defined before being made obsolete).
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
1-alkyl-2-acetylglycerophosphocholine esterase complex
See also the molecular function term '1-alkyl-2-acetylglycerophosphocholine esterase activity ; GO:0003847'.
cellular_component
platelet-activating factor acetylhydrolase complex
An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:10542206
http://purl.org/obo/owl/PMID#PMID_10542206
2-acetyl-1-alkylglycerophosphocholine esterase complex
oligosaccharyltransferase complex
cellular_component
oligosaccharyl transferase complex
OST complex
A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected.
PMID:15835887
http://purl.org/obo/owl/PMID#PMID_15835887
ISBN:0879695595
http://purl.org/obo/owl/ISBN#ISBN_0879695595
gamma-tubulin ring complex
cellular_component
A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins that forms a flexible open ring structure thought to be the unit of nucleation at the minus end of a microtubule.
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
PMID:12134075
http://purl.org/obo/owl/PMID#PMID_12134075
gammaTuRC
gamma-tubulin small complex
cellular_component
gammaTuSC
A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex.
PMID:11297925
http://purl.org/obo/owl/PMID#PMID_11297925
PMID:12134075
http://purl.org/obo/owl/PMID#PMID_12134075
cohesin complex
cellular_component
GO:0008279
GO:0043222
SMC/kleisin ring complex
SMC complex
A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).
PMID:9887095
http://purl.org/obo/owl/PMID#PMID_9887095
GOC:sp
http://purl.org/obo/owl/GOC#GOC_sp
14S cohesin
cohesin core heterodimer
cellular_component
The core heterodimer of a cohesin complex; a structure required for sister chromatid cohesion in eukaryotes.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
Smc1-Smc3 complex
9S cohesin
ATP-sensitive potassium channel complex
cellular_component
A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.2 subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SUR1 subunit stimulates channel activity.
PMID:16308567
http://purl.org/obo/owl/PMID#PMID_16308567
PMID:16956886
http://purl.org/obo/owl/PMID#PMID_16956886
protein serine/threonine phosphatase complex
cellular_component
A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
F-actin capping protein complex
cellular_component
A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments.
ISBN:0198599560
http://purl.org/obo/owl/ISBN#ISBN_0198599560
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
caspase complex
cellular_component
A protein complex that is located in the cytosol and acts as a cysteine-type endopeptidase involved in the apoptotic process; the peptidase activity has specificity for the hydrolysis of aspartyl bonds.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:mtg_apoptosis
http://purl.org/obo/owl/GOC#GOC_mtg_apoptosis
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
eukaryotic translation initiation factor 4 complex
This term was made obsolete because more specific terms were created.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
eIF-4
integrin complex
cellular_component
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
PMID:17543136
http://purl.org/obo/owl/PMID#PMID_17543136
laminin receptor protein
ionotropic glutamate receptor complex
cellular_component
A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex.
URL:http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html
http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html
katanin complex
Consider also annotating to the molecular function term 'microtubule-severing ATPase activity ; GO:0008568'.
cellular_component
A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa).
PMID:10910766
http://purl.org/obo/owl/PMID#PMID_10910766
obsolete cellular component
This term was made obsolete because it is unnecessary in the OBO flat file format.
cellular_component
OBSOLETE. These are terms that have been removed from the active component ontology.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
IkappaB kinase complex
cellular_component
IKK complex
trimeric IKK complex
PMID:21173796
http://purl.org/obo/owl/PMID#PMID_21173796
heterotrimeric IKK complex
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
PMID:20300203
http://purl.org/obo/owl/PMID#PMID_20300203
GOC:ma
http://purl.org/obo/owl/GOC#GOC_ma
PMID:12055104
http://purl.org/obo/owl/PMID#PMID_12055104
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
proteasome activator complex
cellular_component
A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex.
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
PA28
proteasome regulatory particle, base subcomplex
cellular_component
The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
proteasome regulatory particle, lid subcomplex
cellular_component
The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex.
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
epsilon DNA polymerase complex
cellular_component
A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.
PMID:15814431
http://purl.org/obo/owl/PMID#PMID_15814431
PMID:9745046
http://purl.org/obo/owl/PMID#PMID_9745046
DNA polymerase epsilon complex
CORUM:420
http://purl.org/obo/owl/CORUM#CORUM_420
chromatin accessibility complex
GO:0016588
cellular_component
CHRAC
A multisubunit complex that uses ATP to increase the general accessibility of DNA in chromatin. Unlike other known chromatin remodeling complexes, CHRAC can also function during chromatin assembly; it uses ATP to convert irregular chromatin into a regular array of nucleosomes with even spacing.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
PMID:9252192
http://purl.org/obo/owl/PMID#PMID_9252192
ISW2 complex
peptidoglycan-based cell wall
cellular_component
A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
ISBN:0815108893
http://purl.org/obo/owl/ISBN#ISBN_0815108893
murein sacculus
peptidoglycan
envelope
Gram-positive-bacterium-type cell wall
cellular_component
A layer of peptidoglycan found outside of the cytoplasmic membrane. The peptidoglycan is relatively thick (20-80nm) and retains the primary stain of the Gram procedure, thus cells appear blue after Gram stain. The cell walls often contain teichoic acids (acidic anionic polysaccharides) bound to the peptidoglycan. Examples of this component are found in Gram-positive bacteria.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
ISBN:0815108893
http://purl.org/obo/owl/ISBN#ISBN_0815108893
ISBN:0051406910
http://purl.org/obo/owl/ISBN#ISBN_0051406910
cell wall of Gram-positive Bacteria
20-80nm peptidoglycan-based cell wall
Gram-negative-bacterium-type cell wall
cellular_component
The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain.
ISBN:0815108893
http://purl.org/obo/owl/ISBN#ISBN_0815108893
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
1-2nm peptidoglycan-based cell wall
cell wall inner membrane
fungal-type cell wall
cellular_component
A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure.
ISBN:3540601864
http://purl.org/obo/owl/ISBN#ISBN_3540601864
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
PMID:16927300
http://purl.org/obo/owl/PMID#PMID_16927300
PMID:11283274
http://purl.org/obo/owl/PMID#PMID_11283274
PMID:3319422
http://purl.org/obo/owl/PMID#PMID_3319422
beta-glucan-containing cell wall
chitin-containing cell wall
chitin- and beta-glucan-containing cell wall
murein sacculus
This term was made obsolete because it was defined inaccurately.
cellular_component
OBSOLETE. A peptidoglycan polymer that forms the shape-determining structure of the cell all of Gram-negative bacteria.
GOC:ma
http://purl.org/obo/owl/GOC#GOC_ma
cell outer membrane
cellular_component
A lipid bilayer that forms the outermost layer of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
ISBN:0135712254
http://purl.org/obo/owl/ISBN#ISBN_0135712254
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
outer membrane of cell
cell wall inner membrane
This term was made obsolete because it was defined inaccurately.
cellular_component
OBSOLETE. In Gram-negative bacteria the membrane that separates the cytoplasm from the murein sacculus.
GOC:ma
http://purl.org/obo/owl/GOC#GOC_ma
cytoplasmic membrane
bacterial-type flagellum
cellular_component
A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:7787060
http://purl.org/obo/owl/PMID#PMID_7787060
GOC:jh2
http://purl.org/obo/owl/GOC#GOC_jh2
flagellin-based flagellum
pilus
cellular_component
fimbria
fimbriae
fimbrium
pili
A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
Wikipedia:Pilus
http://purl.org/obo/owl/Wikipedia#Wikipedia_Pilus
nucleoid
cellular_component
Wikipedia:Nucleoid
http://purl.org/obo/owl/Wikipedia#Wikipedia_Nucleoid
The region of a bacterial cell, mitochondrion or chloroplast to which the DNA is confined.
GOC:ma
http://purl.org/obo/owl/GOC#GOC_ma
ISBN:3540076689
http://purl.org/obo/owl/ISBN#ISBN_3540076689
3-isopropylmalate dehydratase complex
See also the molecular function term '3-isopropylmalate dehydratase activity ; GO:0003861'.
cellular_component
A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
BRENDA:4.2.1.33
http://purl.org/obo/owl/BRENDA#BRENDA_4.2.1.33
PMID:7026530
http://purl.org/obo/owl/PMID#PMID_7026530
MetaCyc:3-ISOPROPYLMALISOM-CPLX
http://purl.org/obo/owl/MetaCyc#MetaCyc_3-ISOPROPYLMALISOM-CPLX
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
MetaCyc:3-ISOPROPYLMALISOM-CPLX
http://purl.org/obo/owl/MetaCyc#MetaCyc_3-ISOPROPYLMALISOM-CPLX
isopropylmalate isomerase complex
acetyl-CoA carboxylase complex
cellular_component
ACCase complex
A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:12121720
http://purl.org/obo/owl/PMID#PMID_12121720
exodeoxyribonuclease VII complex
cellular_component
An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA.
EC:3.1.11.6
http://purl.org/obo/owl/EC#EC_3.1.11.6
cytochrome o ubiquinol oxidase complex
See also the molecular function term 'cytochrome o ubiquinol oxidase activity ; GO:0008827'.
cellular_component
MetaCyc:CYT-O-UBIOX-CPLX
http://purl.org/obo/owl/MetaCyc#MetaCyc_CYT-O-UBIOX-CPLX
A protein complex that possesses cytochrome o ubiquinol oxidase activity; consists of four polypeptide subunits and associated prosthetic groups.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
MetaCyc:CYT-O-UBIOX-CPLX
http://purl.org/obo/owl/MetaCyc#MetaCyc_CYT-O-UBIOX-CPLX
PMID:11017202
http://purl.org/obo/owl/PMID#PMID_11017202
PMID:3052268
http://purl.org/obo/owl/PMID#PMID_3052268
phosphoribosylaminoimidazole carboxylase complex
See also the molecular function term 'phosphoribosylaminoimidazole carboxylase activity ; GO:0004638'.
cellular_component
A protein complex that possesses phosphoribosylaminoimidazole carboxylase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
alkyl hydroperoxide reductase complex
See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'.
cellular_component
An enzyme complex, usually a homodimer, which directly reduces cellular levels of organic hydroperoxides.
PMID:2649484
http://purl.org/obo/owl/PMID#PMID_2649484
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
BRENDA:1.11.1.15
http://purl.org/obo/owl/BRENDA#BRENDA_1.11.1.15
trimethylamine-N-oxide reductase complex
cellular_component
An enzyme complex that catalyzes the reduction of trimethylamine N-oxide to trimethylamine.
EC:1.6.6.9
http://purl.org/obo/owl/EC#EC_1.6.6.9
ribosomal-protein-alanine N-acetyltransferase complex
cellular_component
An enzyme complex that catalyzes the transfer of an acetyl group to ribosomal-protein alanine, forming ribosomal-protein acetylalanine.
EC:2.3.1.128
http://purl.org/obo/owl/EC#EC_2.3.1.128
D-amino-acid dehydrogenase complex
See also the molecular function term 'D-amino-acid oxidase activity ; GO:0003884'.
cellular_component
A protein complex that possesses D-amino-acid dehydrogenase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
nitrate reductase complex
cellular_component
An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor.
EC:1.7.99.4
http://purl.org/obo/owl/EC#EC_1.7.99.4
formate dehydrogenase complex
cellular_component
An enzyme complex that catalyzes the dehydrogenation of formate to produce carbon dioxide (CO2).
EC:1.2.1.2
http://purl.org/obo/owl/EC#EC_1.2.1.2
NAD(P)+ transhydrogenase complex (AB-specific)
cellular_component
A protein complex that possesses NAD(P)+ transhydrogenase (AB-specific) activity. Homodimeric, trimeric, and heterotetrameric complexes have been identified.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
BRENDA:1.6.1.2
http://purl.org/obo/owl/BRENDA#BRENDA_1.6.1.2
phenylalanine-tRNA ligase complex
cellular_component
An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe).
EC:6.1.1.20
http://purl.org/obo/owl/EC#EC_6.1.1.20
acetate CoA-transferase complex
cellular_component
A heterotetrameric enzyme complex made up of two alpha subunits and two beta subunits. Part of the acetyl-CoA carboxylase complex. Catalyzes the transfer of a carboxyl group to form malonyl-CoA.
PMID:2719476
http://purl.org/obo/owl/PMID#PMID_2719476
PMID:8423010
http://purl.org/obo/owl/PMID#PMID_8423010
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
DNA topoisomerase complex (ATP-hydrolyzing)
See also the molecular function term 'DNA topoisomerase (ATP-hydrolyzing) activity ; GO:0003918'.
cellular_component
Complex that possesses DNA topoisomerase (ATP-hydrolyzing) activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
glycerol-3-phosphate dehydrogenase complex
cellular_component
An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate.
EC:1.1.5.3
http://purl.org/obo/owl/EC#EC_1.1.5.3
glutamate-tRNA ligase complex
cellular_component
An enzyme complex that catalyzes the ligation of glutamate and tRNA(Glu) to form glutamyl-tRNA(Glu).
EC:6.1.1.17
http://purl.org/obo/owl/EC#EC_6.1.1.17
cysteine synthase complex
cellular_component
Cysteine synthase is a multienzyme complex made up, in E. coli, of the heteromeric hexamer serine acetyltransferase and the homodimer O-acetylserine (thiol)-lyase A.
EC:4.2.99.8
http://purl.org/obo/owl/EC#EC_4.2.99.8
MetaCyc:CYSSYNMULTI-CPLX
http://purl.org/obo/owl/MetaCyc#MetaCyc_CYSSYNMULTI-CPLX
3-phenylpropionate dioxygenase complex
See also the molecular function term '3-phenylpropionate dioxygenase activity ; GO:0008695'.
cellular_component
MetaCyc:HCAMULTI-CPLX
http://purl.org/obo/owl/MetaCyc#MetaCyc_HCAMULTI-CPLX
Enzyme complex consisting of four proteins: the two subunits of the hydroxylase component (hcaE and hcaF), a ferredoxin (hcaC) and a ferredoxin reductase (hcaD). Converts 3-phenylpropionic acid (PP) into cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol).
PMID:9603882
http://purl.org/obo/owl/PMID#PMID_9603882
MetaCyc:HCAMULTI-CPLX
http://purl.org/obo/owl/MetaCyc#MetaCyc_HCAMULTI-CPLX
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
holo-[acyl-carrier protein] synthase complex
This term was made obsolete because the catalytic activity resides in a single polypeptide rather than a complex, and the complex is represented by a different GO term.
cellular_component
OBSOLETE. An enzyme complex that catalyzes the formation of holo-[acyl-carrier protein] from CoA and apo-[acyl-carrier protein].
EC:2.7.8.7
http://purl.org/obo/owl/EC#EC_2.7.8.7
holo-ACP synthase complex
sulfate adenylyltransferase complex (ATP)
cellular_component
An enzyme complex that catalyzes the formation adenylylsulfate from sulfate and ATP.
EC:2.7.7.4
http://purl.org/obo/owl/EC#EC_2.7.7.4
sulphate adenylyltransferase complex (ATP)
sulfite reductase complex (NADPH)
See also the molecular function term 'sulfite reductase (NADPH) activity ; GO:0004783'.
cellular_component
A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of sulfite to sulfide.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
BRENDA:1.8.1.2
http://purl.org/obo/owl/BRENDA#BRENDA_1.8.1.2
sulphite reductase complex (NADPH)
exodeoxyribonuclease V complex
cellular_component
An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA.
EC:3.1.11.5
http://purl.org/obo/owl/EC#EC_3.1.11.5
glycolate oxidase complex
cellular_component
An enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and hydrogen peroxide (H2O2). The enzyme is a flavoprotein (FMN).
EC:1.1.3.15
http://purl.org/obo/owl/EC#EC_1.1.3.15
DNA topoisomerase IV complex
cellular_component
A heterodimeric enzyme, which in most bacterial species is composed of two subunits, ParC and ParE. Functions in chromosome segregation and can relax supercoiled DNA.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:7783632
http://purl.org/obo/owl/PMID#PMID_7783632
beta-galactosidase complex
cellular_component
A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species.
PMID:15950161
http://purl.org/obo/owl/PMID#PMID_15950161
EC:3.2.1.23
http://purl.org/obo/owl/EC#EC_3.2.1.23
BRENDA:3.2.1.2
http://purl.org/obo/owl/BRENDA#BRENDA_3.2.1.2
glutamate synthase complex (NADPH)
cellular_component
A complex that possesses glutamate synthase (NADPH) activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
EC:1.4.1.13
http://purl.org/obo/owl/EC#EC_1.4.1.13
biotin carboxylase complex
cellular_component
An enzyme complex that catalyzes the formation of carboxybiotin-carboxyl-carrier protein from biotin-carboxyl-carrier protein and carbon dioxide (CO2).
EC:6.3.4.14
http://purl.org/obo/owl/EC#EC_6.3.4.14
nitrite reductase complex [NAD(P)H]
See also the molecular function term 'nitrite reductase [NAD(P)H] activity ; GO:0008942'.
cellular_component
Complex that possesses nitrite reductase [NAD(P)H] activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
glycine-tRNA ligase complex
cellular_component
A multimeric enzyme complex which, in bacteria, is usually a tetramer of two alpha and two beta chains and in eukaryotes, is usually a homodimer. Functions in the ligation of glycine and tRNA(Gly) to form glycyl-tRNA(Gly).
EC:6.1.1.14
http://purl.org/obo/owl/EC#EC_6.1.1.14
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:15733854
http://purl.org/obo/owl/PMID#PMID_15733854
glycine-tRNA synthetase complex
citrate lyase complex
cellular_component
Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity.
MetaCyc:ACECITLY-CPLX
http://purl.org/obo/owl/MetaCyc#MetaCyc_ACECITLY-CPLX
EC:4.1.3.6
http://purl.org/obo/owl/EC#EC_4.1.3.6
aspartate carbamoyltransferase complex
Note that in eukaryotes, aspartate carbamoyltransferase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term.
cellular_component
A multienzyme complex that catalyzes the formation N-carbamoyl-L-aspartate from carbamoyl phosphate and L-aspartate. It exhibits a variety of architectural organizations, but in all microorganisms the core catalytic component is a homotrimer of approximately 34 kDa polypeptides.
PMID:10447693
http://purl.org/obo/owl/PMID#PMID_10447693
ornithine carbamoyltransferase complex
cellular_component
A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline.
EC:2.1.3.3
http://purl.org/obo/owl/EC#EC_2.1.3.3
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
riboflavin synthase complex
cellular_component
An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine.
EC:2.5.1.9
http://purl.org/obo/owl/EC#EC_2.5.1.9
ethanolamine ammonia-lyase complex
cellular_component
An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia.
EC:4.3.1.7
http://purl.org/obo/owl/EC#EC_4.3.1.7
dihydrolipoamide S-acyltransferase complex
This term was made obsolete because dihydrolipoamide S-acyltransferase activity resides in a single polypeptide.
cellular_component
OBSOLETE. An enzyme complex that catalyzes the transfer of an acyl group from coenzyme A to dihydrolipoamide.
EC:2.3.1.12
http://purl.org/obo/owl/EC#EC_2.3.1.12
dihydrolipoyl dehydrogenase complex
This term was made obsolete because the activity dihydrolipoamide dehydrogenase is held by a single protein (Lpd1 in yeast), which is one of the components of three different complexes: 2-oxoglutarate dehydrogenase, pyruvate dehydrogenase, and branch chain amino acid dehydrogenase, so dihydrolipoamide dehydrogenase is not a complex itself.
cellular_component
OBSOLETE. Complex that possesses dihydrolipoyl dehydrogenase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
dihydrolipoamide dehydrogenase complex
mitochondrial oxoglutarate dehydrogenase complex
See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'.
cellular_component
A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix. An example of this complex is found in Mus musculus.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
MetaCyc:CPLX66-42
http://purl.org/obo/owl/MetaCyc#MetaCyc_CPLX66-42
PMID:10848975
http://purl.org/obo/owl/PMID#PMID_10848975
dihydrolipoamide S-succinyltransferase complex
This term was made obsolete because dihydrolipoamide S-succinyltransferase itself is not a complex, it is a component of the 2-oxoglutarate dehydrogenase complex, the activity dihydrolipoamide S-succinyltransferase is contained in a single polypeptide.
cellular_component
OBSOLETE. An enzyme complex that catalyzes the transfer of succinyl-CoA to dihydrolipoamide to form S-succinyldihydrolipoamide. The enzyme is a component of the multienzyme 2-oxoglutarate dehydrogenase complex.
EC:2.3.1.61
http://purl.org/obo/owl/EC#EC_2.3.1.61
DNA polymerase V complex
cellular_component
A DNA polymerase complex that contains two UmuD' and one UmuC subunits, and acts in translesion DNA synthesis.
PMID:10542196
http://purl.org/obo/owl/PMID#PMID_10542196
PMID:10430871
http://purl.org/obo/owl/PMID#PMID_10430871
aminodeoxychorismate synthase complex
cellular_component
p-aminobenzoate synthetase complex
4-amino-4-deoxychorismate synthase complex
ADC synthase complex
A heterodimeric protein complex that possesses 4-amino-4-deoxychorismate synthase activity.
PMID:7592344
http://purl.org/obo/owl/PMID#PMID_7592344
PMID:2251281
http://purl.org/obo/owl/PMID#PMID_2251281
protein-N(PI)-phosphohistidine-sugar phosphotransferase complex
cellular_component
An enzyme complex that catalyzes the transfer of a phosphate from protein N(PI)-phosphohistidine to a sugar molecule. It is enzyme II of the phosphotransferase system.
EC:2.7.1.69
http://purl.org/obo/owl/EC#EC_2.7.1.69
polyphosphate kinase complex
See also the molecular function term 'polyphosphate kinase activity ; GO:0008976'.
cellular_component
A protein complex that possesses polyphosphate kinase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Type II site-specific deoxyribonuclease complex
cellular_component
A protein complex that functions as an endonuclease to cleave DNA at or near a specific recognition site, when that site is unmethylated. These complexes may be dimers or tetramers; it is also possible for the endonuclease to be in a complex with the corresponding methyltransferase that methylates the recognition site. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell.
PMID:12654995
http://purl.org/obo/owl/PMID#PMID_12654995
Type II restriction enzyme complex
DNA polymerase III complex
cellular_component
A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands.
PMID:12940977
http://purl.org/obo/owl/PMID#PMID_12940977
PMID:11525729
http://purl.org/obo/owl/PMID#PMID_11525729
succinate-CoA ligase complex (ADP-forming)
cellular_component
A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
EC:6.2.1.5
http://purl.org/obo/owl/EC#EC_6.2.1.5
succinyl-CoA synthetase, ADP-forming
CORUM:394
http://purl.org/obo/owl/CORUM#CORUM_394
protein histidine kinase complex
cellular_component
A complex that possesses protein histidine kinase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
enterobactin synthetase complex
cellular_component
enterochelin synthetase complex
MetaCyc:ENTMULTI-CPLX
http://purl.org/obo/owl/MetaCyc#MetaCyc_ENTMULTI-CPLX
A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway.
MetaCyc:ENTMULTI-CPLX
http://purl.org/obo/owl/MetaCyc#MetaCyc_ENTMULTI-CPLX
PMID:9485415
http://purl.org/obo/owl/PMID#PMID_9485415
prepilin peptidase complex
This term was made obsolete because prepilin peptidase is a single gene product, and there is no evidence that it acts as a multimer.
cellular_component
OBSOLETE. An enzyme complex that catalyzes the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group.
EC:3.4.23.43
http://purl.org/obo/owl/EC#EC_3.4.23.43
endopeptidase Clp complex
cellular_component
A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:11352464
http://purl.org/obo/owl/PMID#PMID_11352464
ferredoxin hydrogenase complex
cellular_component
hydrogenase complex
An enzyme complex that catalyzes the oxidation of reduced ferredoxin. Hydrogenase contains iron-sulfur clusters, and some contain nickel; it can use molecular hydrogen for the reduction of a variety of substances.
EC:1.12.7.2
http://purl.org/obo/owl/EC#EC_1.12.7.2
HslUV protease complex
cellular_component
A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other Clp family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, six identical subunits of both the ATPase, ClpY, and the protease, ClpQ, self-assemble into an oligomeric ring, and two rings of each subunit, two ClpQ rings surrounded by single ClpY rings, form a dumbbell-shaped complex.
PMID:12670962
http://purl.org/obo/owl/PMID#PMID_12670962
ClpYQ protease complex
Holliday junction helicase complex
cellular_component
A DNA helicase complex that forms part of a Holliday junction resolvase complex, where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA.
PMID:9442895
http://purl.org/obo/owl/PMID#PMID_9442895
PMID:16935884
http://purl.org/obo/owl/PMID#PMID_16935884
excinuclease repair complex
cellular_component
UvrABC excinuclease complex
Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and one B subunit bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between subunit B and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
PMID:15192705
http://purl.org/obo/owl/PMID#PMID_15192705
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
excinuclease ABC complex
imidazoleglycerol-phosphate synthase complex
See also the molecular function term 'imidazoleglycerol-phosphate synthase activity ; GO:0000107'.
cellular_component
Complex that possesses imidazoleglycerol-phosphate synthase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
imidazoleglycerol phosphate synthase complex
dimethyl sulfoxide reductase complex
cellular_component
dimethyl sulphoxide reductase complex
An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide.
UM-BBD_enzymeID:e0188
http://purl.org/obo/owl/UM-BBD_enzymeID#UM-BBD_enzymeID_e0188
fimbrin
This term was made obsolete because it represents a class of gene products.
cellular_component
OBSOLETE. A class of proteins that are the subunit components of fimbria.
ISBN:0914826859
http://purl.org/obo/owl/ISBN#ISBN_0914826859
pilus shaft
cellular_component
fimbrial shaft
The long, slender, mid section of a pilus.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
pilus tip
cellular_component
The pointed extremity furthest from the cell of a pilus.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
fimbrial tip
bacterial-type flagellum filament
cellular_component
flagellar filament
The long (approximately 20 nm), thin external structure of the flagellum, which acts as a propeller. Examples of this component are found in bacteria.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:12624192
http://purl.org/obo/owl/PMID#PMID_12624192
PMID:10572114
http://purl.org/obo/owl/PMID#PMID_10572114
flagellin-based flagellum filament
bacterial-type flagellum filament cap
cellular_component
flagellar filament cap
flagellin-based flagellum filament cap
The proteinaceous structure at the distal tip of the flagellar filament. Examples of this component are found in bacteria.
PMID:10572114
http://purl.org/obo/owl/PMID#PMID_10572114
PMID:12624192
http://purl.org/obo/owl/PMID#PMID_12624192
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
bacterial-type flagellum hook-filament junction
cellular_component
The region of the flagellum where the hook and filament meet. Examples of this component are found in bacteria.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:10572114
http://purl.org/obo/owl/PMID#PMID_10572114
PMID:12624192
http://purl.org/obo/owl/PMID#PMID_12624192
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
flagellar hook-filament junction
bacterial-type flagellum hook
cellular_component
flagellin-based flagellum hook
flagellar hook
The portion of the flagellum that connects the filament to the basal body. Examples of this component are found in bacteria.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:10572114
http://purl.org/obo/owl/PMID#PMID_10572114
PMID:12624192
http://purl.org/obo/owl/PMID#PMID_12624192
bacterial-type flagellum basal body
cellular_component
One of the three major substructures of the flagellin-based flagellum; a structure consisting of a rod, a series of rings, the Mot proteins, the switch complex and the flagellum-specific export apparatus. The rings anchor the flagellum to the cytoplasmic membrane (MS ring), the peptidoglycan (P ring) and the outer membrane (L ring). Examples of this component are found in bacteria.
PMID:12624192
http://purl.org/obo/owl/PMID#PMID_12624192
PMID:10572114
http://purl.org/obo/owl/PMID#PMID_10572114
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
flagellin-based flagellum basal body
flagellar basal body
bacterial-type flagellum basal body, distal rod
cellular_component
flagellar basal body, distal rod
The portion of the central rod of the flagellar basal body that is distal to the cell membrane; spans most of the distance between the inner and outer membranes. Examples of this component are found in bacteria.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:11133968
http://purl.org/obo/owl/PMID#PMID_11133968
PMID:12624192
http://purl.org/obo/owl/PMID#PMID_12624192
PMID:10572114
http://purl.org/obo/owl/PMID#PMID_10572114
flagellin-based flagellum basal body, distal rod
bacterial-type flagellum basal body, distal rod, L ring
cellular_component
flagellin-based flagellum basal body, distal rod, L ring
One of the rings of the flagellar basal body; anchors the basal body to the outer membrane. Examples of this component are found in bacteria.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:12624192
http://purl.org/obo/owl/PMID#PMID_12624192
PMID:10572114
http://purl.org/obo/owl/PMID#PMID_10572114
flagellar basal body, distal rod, L ring
bacterial-type flagellum basal body, distal rod, P ring
cellular_component
flagellar basal body, distal rod, P ring
One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:12624192
http://purl.org/obo/owl/PMID#PMID_12624192
PMID:10572114
http://purl.org/obo/owl/PMID#PMID_10572114
flagellin-based flagellum basal body, distal rod, P ring
bacterial-type flagellum basal body, proximal rod
cellular_component
The portion of the central rod of the flagellar basal body that is proximal to the cell membrane; proximal rod connects the distal rod to the flagellar motor. Examples of this component are found in bacteria.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:10572114
http://purl.org/obo/owl/PMID#PMID_10572114
PMID:11133968
http://purl.org/obo/owl/PMID#PMID_11133968
PMID:12624192
http://purl.org/obo/owl/PMID#PMID_12624192
flagellin-based flagellum basal body, proximal rod
flagellar basal body, proximal rod
bacterial-type flagellum basal body, MS ring
GO:0009430
cellular_component
flagellar basal body, mounting plate
One of the rings of the flagellar basal body; a double-flanged ring that anchors the basal body to the cytoplasmic membrane. Examples of this component are found in bacteria.
PMID:12624192
http://purl.org/obo/owl/PMID#PMID_12624192
PMID:10572114
http://purl.org/obo/owl/PMID#PMID_10572114
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
flagellin-based flagellum basal body, MS ring
flagellar basal body, MS ring
bacterial-type flagellum basal body, C ring
cellular_component
Cytoplasmic ring located at the base of the flagellar basal body; acts as a rotor; includes three switch proteins, which generate torque and can change their conformational state in a bimodal fashion, so that the motor direction can switch between clockwise and counterclockwise. Examples of this component are found in bacteria.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:12624192
http://purl.org/obo/owl/PMID#PMID_12624192
PMID:10572114
http://purl.org/obo/owl/PMID#PMID_10572114
flagellin-based flagellum basal body, C ring
flagellar basal body, C ring
microtubule-based flagellum
See also the cellular component term 'cilium ; GO:0005929'.
cellular_component
A long, whiplike protrusion from the surface of a eukaryotic cell, whose undulations drive the cell through a liquid medium; similar in structure to a cilium. The flagellum is based on a 9+2 arrangement of microtubules.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
amyloplast
cellular_component
Wikipedia:Amyloplast
http://purl.org/obo/owl/Wikipedia#Wikipedia_Amyloplast
A plastid whose main function is to synthesize and store starch.
ISBN:0140514031
http://purl.org/obo/owl/ISBN#ISBN_0140514031
photosynthetic electron transport chain
This term was made obsolete because it represents a process.
cellular_component
OBSOLETE. A series of membrane-linked oxidation-reduction reactions in which electrons are transferred from an initial electron donor through a series of intermediates to a final electron acceptor (usually oxygen).
ISBN:014051403
http://purl.org/obo/owl/ISBN#ISBN_014051403
GOC:mtg_electron_transport
http://purl.org/obo/owl/GOC#GOC_mtg_electron_transport
thylakoid light-harvesting complex
cellular_component
A thylakoid membrane complex of chlorophylls a and b together with chlorophyll a-b binding proteins. In addition, LHCs contain a number of other proteins, the function of which is speculative, together with accessory pigments. The LHCs capture and transfer energy to photosystems I and II. An example of this is found in Arabidopsis thaliana.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
cell plate
cellular_component
The nascent cell membrane and cell wall structure that forms between two daughter nuclei near the center of a dividing plant cell. It develops at the equitorial region of the phragmoplast. It grows outwards to join with the lateral walls and form two daughter cells.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
Wikipedia:Cell_plate
http://purl.org/obo/owl/Wikipedia#Wikipedia_Cell_plate
plant-type cell wall
cellular_component
cellulose and pectin-containing cell wall
A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances.
ISBN:0471245208
http://purl.org/obo/owl/ISBN#ISBN_0471245208
plasmodesma
cellular_component
Wikipedia:Plasmodesma
http://purl.org/obo/owl/Wikipedia#Wikipedia_Plasmodesma
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
plasmodesmata
chloroplast
cellular_component
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
ISBN:0471245208
http://purl.org/obo/owl/ISBN#ISBN_0471245208
Wikipedia:Chloroplast
http://purl.org/obo/owl/Wikipedia#Wikipedia_Chloroplast
plastid chromosome
cellular_component
A circular DNA molecule containing plastid encoded genes.
ISBN:0943883999
http://purl.org/obo/owl/ISBN#ISBN_0943883999
chromoplast
cellular_component
Wikipedia:Chromoplast
http://purl.org/obo/owl/Wikipedia#Wikipedia_Chromoplast
A plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments.
ISBN:0471245208
http://purl.org/obo/owl/ISBN#ISBN_0471245208
plasmodesmatal desmotubule
cellular_component
GO:0009572
A tightly wound cylinder of membrane that is located within the plasmodesmal pore and runs the length of the plasmodesma. The desmotubule likely provides a rigid stability to plasmodesmata and confers a fixed diameter and pore size to the plasmodesmal canal, and is linked to the endoplasmic reticulum in each of the adjacent cell.
URL:http://biology.kenyon.edu/edwards/project/greg/pd.htm
http://biology.kenyon.edu/edwards/project/greg/pd.htm
desmotubule central rod
plasmodesmatal endoplasmic reticulum
cellular_component
Endoplasmic reticulum found in plasmodesmata, junctions connecting the cytoplasm of adjacent plant cells.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
plasmodesmatal ER
cytochrome b6f complex
cellular_component
cytochrome b6-f complex
cytochrome b(6)f complex
cytochrome b6/f complex
Complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome f, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species.
PMID:16352458
http://purl.org/obo/owl/PMID#PMID_16352458
PMID:16228398
http://purl.org/obo/owl/PMID#PMID_16228398
ISBN:0943883999
http://purl.org/obo/owl/ISBN#ISBN_0943883999
cyt b(6)f complex
cyt b6-f complex
cyt b6/f complex
cyt b6f complex
Wikipedia:Cytochrome_b6f_complex
http://purl.org/obo/owl/Wikipedia#Wikipedia_Cytochrome_b6f_complex
etioplast
cellular_component
A plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions.
ISBN:0943883999
http://purl.org/obo/owl/ISBN#ISBN_0943883999
Wikipedia:Etioplast
http://purl.org/obo/owl/Wikipedia#Wikipedia_Etioplast
glyoxysome
cellular_component
A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds.
GOC:dhl
http://purl.org/obo/owl/GOC#GOC_dhl
ISBN:0140514031
http://purl.org/obo/owl/ISBN#ISBN_0140514031
Wikipedia:Glyoxysome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Glyoxysome
granal stacked thylakoid
cellular_component
Appressed thylakoid membranes that are part of a granum (stacked regions). A characteristic of these appressed regions is the preferential localization of photosystem II.
GOC:lr
http://purl.org/obo/owl/GOC#GOC_lr
chloroplast stacked thylakoid
leucoplast
cellular_component
A colorless plastid involved in the synthesis of monoterpenes.
ISBN:0943883999
http://purl.org/obo/owl/ISBN#ISBN_0943883999
Wikipedia:Leucoplast
http://purl.org/obo/owl/Wikipedia#Wikipedia_Leucoplast
PSII associated light-harvesting complex II
cellular_component
LHCII
Protein-pigment complex associated with photosystem II.
GOC:lr
http://purl.org/obo/owl/GOC#GOC_lr
ISBN:0582227089
http://purl.org/obo/owl/ISBN#ISBN_0582227089
PSI associated light-harvesting complex I
cellular_component
LHCI
Protein-pigment complex associated with photosystem I.
GOC:lr
http://purl.org/obo/owl/GOC#GOC_lr
middle lamella
cellular_component
Layer of intercellular material, chiefly pectic substances, cementing together the primary walls of contiguous cells.
ISBN:0471245208
http://purl.org/obo/owl/ISBN#ISBN_0471245208
Wikipedia:Middle_lamella
http://purl.org/obo/owl/Wikipedia#Wikipedia_Middle_lamella
photosystem
GO:0030090
cellular_component
A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species.
GOC:ds
http://purl.org/obo/owl/GOC#GOC_ds
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0140514031
http://purl.org/obo/owl/ISBN#ISBN_0140514031
PMID:9821949
http://purl.org/obo/owl/PMID#PMID_9821949
Wikipedia:Photosystem
http://purl.org/obo/owl/Wikipedia#Wikipedia_Photosystem
reaction centre
reaction center
photosystem I
cellular_component
A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation).
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:ds
http://purl.org/obo/owl/GOC#GOC_ds
PMID:9821949
http://purl.org/obo/owl/PMID#PMID_9821949
ISBN:0140514031
http://purl.org/obo/owl/ISBN#ISBN_0140514031
photosystem II
cellular_component
Wikipedia:Photosystem_II
http://purl.org/obo/owl/Wikipedia#Wikipedia_Photosystem_II
A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0943088399
http://purl.org/obo/owl/ISBN#ISBN_0943088399
GOC:ds
http://purl.org/obo/owl/GOC#GOC_ds
PMID:9821949
http://purl.org/obo/owl/PMID#PMID_9821949
phragmoplast
cellular_component
Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules.
ISBN:0471245208
http://purl.org/obo/owl/ISBN#ISBN_0471245208
Wikipedia:Phragmoplast
http://purl.org/obo/owl/Wikipedia#Wikipedia_Phragmoplast
phragmosome
cellular_component
A flattened membranous vesicle containing cell wall components.
ISBN:0943883999
http://purl.org/obo/owl/ISBN#ISBN_0943883999
Wikipedia:Phragmosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Phragmosome
plastid envelope
cellular_component
The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
GOC:jy
http://purl.org/obo/owl/GOC#GOC_jy
plastid outer membrane
cellular_component
The outer, i.e. cytoplasm-facing, lipid bilayer of the plastid envelope.
GOC:lr
http://purl.org/obo/owl/GOC#GOC_lr
plastid inner membrane
cellular_component
The inner, i.e. lumen-facing, lipid bilayer of the plastid envelope; also faces the plastid stroma.
GOC:lr
http://purl.org/obo/owl/GOC#GOC_lr
plastid intermembrane space
cellular_component
plastid envelope lumen
The region between the inner and outer lipid bilayers of the plastid envelope.
GOC:lr
http://purl.org/obo/owl/GOC#GOC_lr
primary cell wall
cellular_component
A plant cell wall that is still able to expand, permitting cell growth. Primary cell walls contain more pectin than secondary walls and no lignin is present.
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
PMID:9442872
http://purl.org/obo/owl/PMID#PMID_9442872
secondary cell wall
cellular_component
A plant cell wall that is no longer able to expand and so does not permit growth. Secondary cell walls contain less pectin that primary cell walls. The secondary cell is mostly composed of cellulose and is strengthened with lignin.
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
ISBN:0943088399
http://purl.org/obo/owl/ISBN#ISBN_0943088399
Wikipedia:Secondary_cell_wall
http://purl.org/obo/owl/Wikipedia#Wikipedia_Secondary_cell_wall
plastid stroma
cellular_component
The proteinaceous ground substance of plastids.
ISBN:047142520
http://purl.org/obo/owl/ISBN#ISBN_047142520
chloroplast stromal thylakoid
cellular_component
Unstacked thylakoids that connect the grana stacks through the stroma.
ISBN:0943883999
http://purl.org/obo/owl/ISBN#ISBN_0943883999
chloroplast thylakoid
cellular_component
Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0943883999
http://purl.org/obo/owl/ISBN#ISBN_0943883999
chloroplast thylakoid membrane
cellular_component
The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:lr
http://purl.org/obo/owl/GOC#GOC_lr
plastid
cellular_component
Wikipedia:Plastid
http://purl.org/obo/owl/Wikipedia#Wikipedia_Plastid
Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
proplastid
cellular_component
The precursor of other plastids.
ISBN:0943883999
http://purl.org/obo/owl/ISBN#ISBN_0943883999
photosystem I reaction center
cellular_component
photosystem I reaction centre
A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin.
ISBN:0943088399
http://purl.org/obo/owl/ISBN#ISBN_0943088399
GOC:kd
http://purl.org/obo/owl/GOC#GOC_kd
photosystem II reaction center
cellular_component
photosystem II reaction centre
An integral membrane complex containing P680, the chlorophyll a molecule that functions as a primary electron donor. In the light, functioning as a water-plastoquinone oxidoreductase, it transfers electrons from water to plastoquinone.
GOC:kd
http://purl.org/obo/owl/GOC#GOC_kd
ISBN:0943088399
http://purl.org/obo/owl/ISBN#ISBN_0943088399
etioplast prolamellar body
cellular_component
A three dimensional regular lattice found in etioplasts. It is composed of a continuous system of tubules but when exposed to light the symmetrical arrangement is rapidly lost as tubules become pinched off into two dimensional sections of lattice. These for perforated sheets of membrane that move apart, extend and increase, finally establishing the typical granal and intergranal lamellae of the mature chloroplast.
ISBN:0140514031
http://purl.org/obo/owl/ISBN#ISBN_0140514031
granum
cellular_component
Distinct stack of lamellae seen within chloroplasts. Grana contain the pigments, electron transfer compounds, and enzymes essential to the light-dependent reactions of photosynthesis.
ISBN:014051403
http://purl.org/obo/owl/ISBN#ISBN_014051403
chloroplast thylakoid lumen
cellular_component
The cavity enclosed within the chloroplast thylakoid membrane. An example of this component is found in Arabidopsis thaliana.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:006501037
http://purl.org/obo/owl/ISBN#ISBN_006501037
chloroplast ATP synthase complex
cellular_component
The protein complex that catalyzes the phosphorylation of ADP to ATP in chloroplasts.
ISBN:019854768
http://purl.org/obo/owl/ISBN#ISBN_019854768
elaioplast
cellular_component
A leucoplast in which oil is stored.
ISBN:0140514031
http://purl.org/obo/owl/ISBN#ISBN_0140514031
Wikipedia:Elaioplast
http://purl.org/obo/owl/Wikipedia#Wikipedia_Elaioplast
plasmodesmatal cytoplasmic sleeve
cellular_component
The space between the plasma membrane and the desmotubule of a plasmodesma.
URL:http://biology.kenyon.edu/edwards/project/greg/pd.htm
http://biology.kenyon.edu/edwards/project/greg/pd.htm
plasmodesmatal cytoplasmic annulus
plastid ribosome
cellular_component
A ribosome contained within a plastid.
GOC:tair_curators
http://purl.org/obo/owl/GOC#GOC_tair_curators
plasmodesmatal plasma membrane
cellular_component
The portion of the plasma membrane surrounding a plasmodesma.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cellulose microfibril
cellular_component
A microfibril composed of cellulose arranged in orthogonal layers. Cellulose is a straight chain polysaccharide composed of B(14) linked glucose subunits. It is a major component of plant cell walls. Higher plant microfibrils are about 10nm in diameter and extremely long in relation to their width. The cellulose molecules are oriented parallel to the long axis of the microfibril in a paracrystalline array, which provides great tensile strength. The microfibrils are held in place by the wall matrix and their orientation is closely controlled by the cell.
ISBN:0943088399
http://purl.org/obo/owl/ISBN#ISBN_0943088399
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
primary plasmodesma
cellular_component
simple plasmodesma
A plasmodesma that consists of a simple, single channel; found predominantly in young tissue and formed as a function of cell plate formation during cytokinesis.
PMID:15012255
http://purl.org/obo/owl/PMID#PMID_15012255
secondary plasmodesma
cellular_component
A plasmodesma with a branched structure, often with many channels leading into a larger central cavity; found in older tissues and usually derived from preexisting primary plasmodesmata.
PMID:15012255
http://purl.org/obo/owl/PMID#PMID_15012255
amyloplast starch grain
cellular_component
Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in amyloplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped.
PMID:11217978
http://purl.org/obo/owl/PMID#PMID_11217978
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
amyloplast starch granule
chloroplast starch grain
cellular_component
chloroplast starch granule
Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in chloroplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
chloroplast stroma
cellular_component
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
proplastid stroma
cellular_component
The space enclosed by the double membrane of a proplastid.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
chloroplast ribulose bisphosphate carboxylase complex
cellular_component
A complex, located in the chloroplast, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. An example of this component is found in Arabidopsis thaliana.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
chloroplast RubisCO complex
preprophase band
cellular_component
Wikipedia:Preprophase_band
http://purl.org/obo/owl/Wikipedia#Wikipedia_Preprophase_band
A dense band of microtubules, 1-3 pm wide, that appears just beneath the cell membrane before the start of cell division in the cells of higher plants. It precedes the onset of prophase and then disappears as mitosis begins, yet it somehow determines the plane of orientation of the new cell plate forming in late telophase and marks the zone of the parental cell wall where fusion with the growing cell plate ultimately occurs.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
chromoplast stroma
cellular_component
The space enclosed by the double membrane of a chromoplast but excluding the photosynthetic material.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
leucoplast stroma
cellular_component
The space enclosed by the double membrane of a leucoplast.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
elaioplast stroma
cellular_component
The space enclosed by the double membrane of an elaioplast.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
etioplast stroma
cellular_component
The space enclosed by the double membrane of an etioplast but excluding the prothylakoid space. It contains the etioplast DNA.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
thylakoid
A thylakoid is not considered an organelle, but some thylakoids are part of organelles.
cellular_component
A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.
GOC:ds
http://purl.org/obo/owl/GOC#GOC_ds
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
Wikipedia:Thylakoid
http://purl.org/obo/owl/Wikipedia#Wikipedia_Thylakoid
photosynthetic membrane
thylakoid (sensu Bacteria)
This term was made obsolete because more specific children exist.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
oxygen evolving complex
cellular_component
A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ).
InterPro:IPR002683
http://purl.org/obo/owl/InterPro#InterPro_IPR002683
Wikipedia:Oxygen_evolving_complex
http://purl.org/obo/owl/Wikipedia#Wikipedia_Oxygen_evolving_complex
PSII associated light-harvesting complex II, core complex
cellular_component
The pigment-protein complex primarily associated to PSII in higher plants, green algae and cyanobacteria that directly transfers electrons to the reaction center.
GOC:lr
http://purl.org/obo/owl/GOC#GOC_lr
PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex
PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex
PSII associated light-harvesting complex II, core complex, LHCIId subcomplex
PSII associated light-harvesting complex II, peripheral complex
cellular_component
Pigment-protein complex primarily associated to PSII in plants, green algae and cyanobacteria. Involved in state transitions that cause migration to PSI under certain environmental conditions such as high light.
GOC:lr
http://purl.org/obo/owl/GOC#GOC_lr
plant-type vacuole membrane
cellular_component
vacuolar membrane
membrane of vacuole with cell cycle-independent morphology
The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0471245208
http://purl.org/obo/owl/ISBN#ISBN_0471245208
tonoplast
chloroplast inner membrane
cellular_component
The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma.
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
chloroplast inner envelope
chloroplast outer membrane
cellular_component
chloroplast outer envelope
The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope.
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
photosystem I antenna complex
cellular_component
The antenna complex of photosystem I. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs).
ISBN:0716731363
http://purl.org/obo/owl/ISBN#ISBN_0716731363
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
photosystem II antenna complex
cellular_component
The antenna complex of photosystem II. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs).
ISBN:0716731363
http://purl.org/obo/owl/ISBN#ISBN_0716731363
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
SCF complex substrate recognition subunit
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
OBSOLETE. The portion of the SCF ubiquitin ligase complex that contains sites required for recognition (and recruitment) of the substrate to the complex.
PMID:11790542
http://purl.org/obo/owl/PMID#PMID_11790542
PMID:9857172
http://purl.org/obo/owl/PMID#PMID_9857172
chloroplastic endopeptidase Clp complex
cellular_component
A Clp endopeptidase complex located in the chloroplast.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mitochondrial endopeptidase Clp complex
cellular_component
A Clp endopeptidase complex located in the mitochondrion.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cyanelle
cellular_component
muroplast
ISBN:1402001894
http://purl.org/obo/owl/ISBN#ISBN_1402001894
cyanoplast
ISBN:1402001894
http://purl.org/obo/owl/ISBN#ISBN_1402001894
A plastid that contains unstacked, phycobilisome-bearing thylakoid membranes and is surrounded by a double membrane with a peptidoglycan layer in the intermembrane space between the two envelope membranes. Cyanelles are characteristic of algae in the class Glaucophyta, and may represent an ancestral form of plastid.
ISBN:052131687
http://purl.org/obo/owl/ISBN#ISBN_052131687
ISBN:1402001894
http://purl.org/obo/owl/ISBN#ISBN_1402001894
cyanelle thylakoid
cellular_component
A thylakoid found in a cyanelle, which is a type of plastid found in certain algae. The cyanelle contains a photosynthetic membrane resembling that of cyanobacteria.
GOC:lr
http://purl.org/obo/owl/GOC#GOC_lr
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
external side of plasma membrane
cellular_component
The side of the plasma membrane that is opposite to the side that faces the cytoplasm.
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
outer surface of cytoplasmic membrane
juxtamembrane
internal side of plasma membrane
cellular_component
The side of the plasma membrane that faces the cytoplasm.
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
juxtamembrane
auxin efflux carrier complex
cellular_component
The protein complex associated with the plasma membrane of certain plant cells (e.g. root cortex, epidermal cells) that functions to transport auxin out of the cell.
PMID:9843496
http://purl.org/obo/owl/PMID#PMID_9843496
fatty acid elongase complex
cellular_component
A tetrameric complex of four different subunits which catalyzes the elongation of fatty acids chains 2 carbon units at a time in the synthesis of very long chain fatty acids.
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
basal plasma membrane
cellular_component
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
longitudinal side of cell surface
cellular_component
The side of the cell parallel to the zygotic axis.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:sm
http://purl.org/obo/owl/GOC#GOC_sm
chloroplast envelope
cellular_component
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
cell surface
Note that this term is intended to annotate gene products that are attached (integrated or loosely bound) to the plasma membrane or cell wall.
GO:0009928
cellular_component
GO:0009929
The external part of the cell wall and/or plasma membrane.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
GOC:sm
http://purl.org/obo/owl/GOC#GOC_sm
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
cell associated
cell bound
cortical microtubule, transverse to long axis
cellular_component
Arrays of microtubules underlying and connected to the plasma membrane, in the cortical cytosol, oriented mainly with their axes transverse to the long axis of the cell (and root in plants). In plants it influences the direction of cellulose microfibril deposition.
ISBN:0943088399
http://purl.org/obo/owl/ISBN#ISBN_0943088399
Toc complex
cellular_component
Protein translocon complex at the chloroplast outer membrane.
PMID:10646606
http://purl.org/obo/owl/PMID#PMID_10646606
magnesium chelatase complex
cellular_component
A heterotrimeric enzyme complex composed of three subunits, all of which are required for enzyme activity, which catalyzes the chelation of Mg by proto IX in an ATP-dependent manner.
PMID:11842180
http://purl.org/obo/owl/PMID#PMID_11842180
endosome membrane
cellular_component
The lipid bilayer surrounding an endosome.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
external side of endosome membrane
cellular_component
The external (cytoplasmic face) of an endosome membrane.
GOC:lr
http://purl.org/obo/owl/GOC#GOC_lr
ER body
cellular_component
A novel compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species.
PMID:11577182
http://purl.org/obo/owl/PMID#PMID_11577182
endoplasmic reticulum body
thioglucosidase complex
cellular_component
A large (200-800 kDa) multiprotein complex formed by 70-kDa and 5-kDa myrosinases, myrosinase- binding proteins (MBPs), MBP-related proteins and myrosinase-associated proteins. The complex has been identified in Brassica napus seeds.
PMID:10682349
http://purl.org/obo/owl/PMID#PMID_10682349
myrosinase complex
glucose-1-phosphate adenylyltransferase complex
cellular_component
Complex that catalyzes the synthesis of ADP-glucose and pyrophosphate from glucose-1-phosphate and ATP. In plants, the complex is a heterotetramer composed of two types of subunits (small and large). In bacteria, the enzyme complex is composed of four identical subunits.
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
PMID:12748181
http://purl.org/obo/owl/PMID#PMID_12748181
plastid pyruvate dehydrogenase complex
cellular_component
dehydrogenase complex
Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). This complex is found in plant plastids and is distinct from the one found in mitochondria.
PMID:9393637
http://purl.org/obo/owl/PMID#PMID_9393637
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
chloroplast outer membrane translocon
cellular_component
The protein transport machinery of the chloroplast outer membrane that contains at least three components Toc159, Toc75 and Toc34, interacts with precursor proteins which are imported into the chloroplast in a GTP dependant manner.
PMID:11299338
http://purl.org/obo/owl/PMID#PMID_11299338
senescence-associated vacuole
cellular_component
A lytic vacuole that is maintained at acidic pH and has different tonoplast composition compared to the central vacuole. Found during leaf senescence and develops in the peripheral cytoplasm of cells that contain chloroplast.
PMID:15743448
http://purl.org/obo/owl/PMID#PMID_15743448
senescence associated vacuole
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
plastoglobule
GO:0010502
cellular_component
A lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids.
PMID:16461379
http://purl.org/obo/owl/PMID#PMID_16461379
GOC:tair_curators
http://purl.org/obo/owl/GOC#GOC_tair_curators
plastoglobuli
PG
pyrophosphate-dependent phosphofructokinase complex
cellular_component
PFK complex
Heterodimeric complex that catalyzes the pyrophosphate-dependent phosphorylation of D-fructose 6-phosphate into D-fructose 1,6-bisphosphate.
PMID:2170409
http://purl.org/obo/owl/PMID#PMID_2170409
pyrophosphate-dependent phosphofructokinase complex, alpha-subunit complex
cellular_component
PFK complex, alpha-subunit
Refers to the alpha subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity.
PMID:2170409
http://purl.org/obo/owl/PMID#PMID_2170409
pyrophosphate-dependent phosphofructokinase complex, beta-subunit complex
cellular_component
PFK complex, beta-subunit
Refers to the beta subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity.
PMID:2170409
http://purl.org/obo/owl/PMID#PMID_2170409
stromule
cellular_component
Stroma-filled tubule
Wikipedia:Stromule
http://purl.org/obo/owl/Wikipedia#Wikipedia_Stromule
Thin filamentous structure extending from the surface of all plastid types examined so far, including chloroplast, proplastid, etioplast, leucoplast, amyloplast, and chromoplast. In general, stromules are more abundant in tissues containing non-green plastids, and in cells containing smaller plastids. The primary function of stromules is still unresolved, although the presence of stromules markedly increases the plastid surface area, potentially increasing transport to and from the cytosol. Other functions of stromules, such as transfer of macromolecules between plastids and starch granule formation in cereal endosperm, may be restricted to particular tissues and cell types.
PMID:16582010
http://purl.org/obo/owl/PMID#PMID_16582010
PMID:15699062
http://purl.org/obo/owl/PMID#PMID_15699062
PMID:15272881
http://purl.org/obo/owl/PMID#PMID_15272881
cellulose synthase complex
cellular_component
CESA complex
A large, multimeric protein complex, organized in a rosette, which catalyzes the biosynthesis of cellulose for the plant cell wall.
PMID:18485800
http://purl.org/obo/owl/PMID#PMID_18485800
PMID:21307367
http://purl.org/obo/owl/PMID#PMID_21307367
PMID:12514238
http://purl.org/obo/owl/PMID#PMID_12514238
external side of cell wall
cellular_component
The side of the cell wall that is opposite to the side that faces the cell and its contents.
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
extracellular isoamylase complex
cellular_component
A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in animals are localized in the extracellular space.
GOC:tair_curators
http://purl.org/obo/owl/GOC#GOC_tair_curators
chloroplast isoamylase complex
cellular_component
A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in plants are intracellular and probably chloroplast localized.
GOC:tair_curators
http://purl.org/obo/owl/GOC#GOC_tair_curators
chromocenter
cellular_component
A region in which centric, heterochromatic portions of one or more chromosomes form a compact structure.
PMID:16831888
http://purl.org/obo/owl/PMID#PMID_16831888
PMID:12384572
http://purl.org/obo/owl/PMID#PMID_12384572
PMID:15053486
http://purl.org/obo/owl/PMID#PMID_15053486
perinucleolar chromocenter
cellular_component
A chromocenter adjacent to the nucleolus.
PMID:15805479
http://purl.org/obo/owl/PMID#PMID_15805479
nuclear dicing body
cellular_component
A small round nuclear body, measuring 0.2-0.8 microns in diameter that is diffusely distributed throughout the nucleoplasm. Several proteins known to be involved in miRNA processing have been localized to these structures. D-bodies are thought to be involved in primary-miRNA processing and/or storage/assembly of miRNA processing complexes.
PMID:17442570
http://purl.org/obo/owl/PMID#PMID_17442570
D body
cytoplasmic stress granule
cellular_component
cytoplasmic mRNP granule
Wikipedia:Stress_granule
http://purl.org/obo/owl/Wikipedia#Wikipedia_Stress_granule
stress granule
P-body
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
GOC:ans
http://purl.org/obo/owl/GOC#GOC_ans
PMID:17601829
http://purl.org/obo/owl/PMID#PMID_17601829
PMID:17967451
http://purl.org/obo/owl/PMID#PMID_17967451
PMID:20368989
http://purl.org/obo/owl/PMID#PMID_20368989
PMID:17284590
http://purl.org/obo/owl/PMID#PMID_17284590
NAD(P)H dehydrogenase complex (plastoquinone)
cellular_component
Complex that possesses NAD(P)H dehydrogenase (plastoquinone) activity. The complex is one of the components of the electron transport chain. It is involved in electron transport from an unidentified electron donor, possibly NADH, NADPH or ferredoxin(Fd) to the plastoquinone pool.
PMID:15608332
http://purl.org/obo/owl/PMID#PMID_15608332
endomembrane system
cellular_component
Wikipedia:Endomembrane_system
http://purl.org/obo/owl/Wikipedia#Wikipedia_Endomembrane_system
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
GOC:lh
http://purl.org/obo/owl/GOC#GOC_lh
vesicle membrane
cellular_component
NIF_Subcellular:sao1153182838
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1153182838
The lipid bilayer surrounding any membrane-bounded vesicle in the cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ER to Golgi transport vesicle membrane
GO:0030664
cellular_component
The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi.
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
GOC:ascb_2009
http://purl.org/obo/owl/GOC#GOC_ascb_2009
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
ER-Golgi transport vesicle membrane
ER to Golgi constitutive secretory pathway transport vesicle membrane
endoplasmic reticulum-Golgi transport vesicle membrane
endoplasmic reticulum to Golgi transport vesicle membrane
COPII coated vesicle membrane
Golgi to ER transport vesicle membrane
cellular_component
Golgi to endoplasmic reticulum transport vesicle membrane
Golgi to ER constitutive secretory pathway transport vesicle membrane
The lipid bilayer surrounding a vesicle transporting substances from the Golgi to the ER.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
Golgi-ER transport vesicle membrane
Golgi-endoplasmic reticulum transport vesicle membrane
inter-Golgi transport vesicle membrane
cellular_component
inter-Golgi transport constitutive secretory pathway transport vesicle membrane
The lipid bilayer surrounding a vesicle transporting substances within the Golgi.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
trans-Golgi network transport vesicle membrane
cellular_component
The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
TGN transport vesicle membrane
trans-Golgi network constitutive secretory pathway transport vesicle membrane
monolayer-surrounded lipid storage body
GO:0009520
cellular_component
oil body
A subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. The storage body has a droplet of triglyceride surrounded by a monolayer of phospholipids, interacting with the triglycerides and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0943088372
http://purl.org/obo/owl/ISBN#ISBN_0943088372
oilbody
Wikipedia:Oil_body
http://purl.org/obo/owl/Wikipedia#Wikipedia_Oil_body
spherosome
oleosome
postsynaptic density
cellular_component
Wikipedia:Postsynaptic_density
http://purl.org/obo/owl/Wikipedia#Wikipedia_Postsynaptic_density
NIF_Subcellular:sao1196688972
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1196688972
The post synaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases.
PMID:14532281
http://purl.org/obo/owl/PMID#PMID_14532281
URL:http://molneuro.kaist.ac.kr/psd
http://molneuro.kaist.ac.kr/psd
GOC:sjp
http://purl.org/obo/owl/GOC#GOC_sjp
Wikipedia:Postsynaptic_density
http://purl.org/obo/owl/Wikipedia#Wikipedia_Postsynaptic_density
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
GOC:ef
http://purl.org/obo/owl/GOC#GOC_ef
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
post synaptic density
post-synaptic density
junctional sarcoplasmic reticulum membrane
cellular_component
The part of the sarcoplasmic reticulum membrane that contains calcium release channels, is devoted to calcium release and is juxtaposed to transverse tubule membrane. The junctional sarcoplasmic reticulum membrane consists of the junctional region of the terminal cisterna membrane.
GOC:mtg_muscle
http://purl.org/obo/owl/GOC#GOC_mtg_muscle
free sarcoplasmic reticulum membrane
cellular_component
The part of the sarcoplasmic reticulum membrane that contains calcium pumps and is devoted to calcium uptake. The free sarcoplasmic reticulum membrane consists of the longitudinal sarcoplasmic reticulum membrane and the non-junctional region of the terminal cisterna membrane.
GOC:mtg_muscle
http://purl.org/obo/owl/GOC#GOC_mtg_muscle
intercalated disc
cellular_component
Wikipedia:Intercalated_disc
http://purl.org/obo/owl/Wikipedia#Wikipedia_Intercalated_disc
intercalated disk
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
GOC:mtg_muscle
http://purl.org/obo/owl/GOC#GOC_mtg_muscle
PMID:11732910
http://purl.org/obo/owl/PMID#PMID_11732910
C zone
cellular_component
A region of the A band in which myosin-binding protein C is located and that can be seen by electron microscopy. This is a functional zone that also includes myosin.
GOC:mtg_muscle
http://purl.org/obo/owl/GOC#GOC_mtg_muscle
spectrin-associated cytoskeleton
cellular_component
The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane.
GOC:mtg_muscle
http://purl.org/obo/owl/GOC#GOC_mtg_muscle
PMID:15970557
http://purl.org/obo/owl/PMID#PMID_15970557
longitudinal sarcoplasmic reticulum
cellular_component
The portion of the free sarcoplasmic reticulum consisting of longitudinal tubules that connect terminal cisternae.
GOC:mtg_muscle
http://purl.org/obo/owl/GOC#GOC_mtg_muscle
terminal cisterna
cellular_component
Wikipedia:Terminal_cisterna
http://purl.org/obo/owl/Wikipedia#Wikipedia_Terminal_cisterna
The portion of sarcoplasmic reticulum devoted to calcium ion storage and calcium ion release.
GOC:mtg_muscle
http://purl.org/obo/owl/GOC#GOC_mtg_muscle
longitudinal sarcoplasmic reticulum lumen
cellular_component
The region between the inner and outer lipid bilayers of the longitudinal sarcoplasmic reticulum envelope. The longitudinal sarcoplasmic reticulum lumen is continuous with the lumen contained within the terminal cisternae.
GOC:mtg_muscle
http://purl.org/obo/owl/GOC#GOC_mtg_muscle
terminal cisterna lumen
cellular_component
The region between the inner and outer lipid bilayers of the terminal cisterna envelope. This space is enriched in calsequestrin.
GOC:mtg_muscle
http://purl.org/obo/owl/GOC#GOC_mtg_muscle
Cajal body
cellular_component
A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.
URL:http://genetics.cwru.edu/matera3.html
http://genetics.cwru.edu/matera3.html
PMID:7559785
http://purl.org/obo/owl/PMID#PMID_7559785
PMID:11031238
http://purl.org/obo/owl/PMID#PMID_11031238
PMID:10944589
http://purl.org/obo/owl/PMID#PMID_10944589
coiled body
Wikipedia:Cajal_body
http://purl.org/obo/owl/Wikipedia#Wikipedia_Cajal_body
Gems
methane monooxygenase complex
cellular_component
A protein complex that possesses methane monooxygenase activity; dimeric and trimeric complexes have been characterized.
BRENDA:1.14.13.25
http://purl.org/obo/owl/BRENDA#BRENDA_1.14.13.25
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
type II protein secretion system complex
Note that the type II protein secretion system complex does not include components of the Sec or Tat pathways. For components of these pathways, consider annotating to 'cell envelope Sec complex ; GO:0031522' or 'TAT protein translocation system complex ; GO:0033281'.
cellular_component
A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex.
PMID:16448494
http://purl.org/obo/owl/PMID#PMID_16448494
general secretion pathway-associated complex
T2SS-associated complexes
main terminal branch
Sec-dependent secretion system-associated complex
MTB
actin cytoskeleton
cellular_component
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
ISBN:0395825172
http://purl.org/obo/owl/ISBN#ISBN_0395825172
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
microtubule cytoskeleton
cellular_component
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
ISBN:0395825172
http://purl.org/obo/owl/ISBN#ISBN_0395825172
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
large ribosomal subunit
cellular_component
ribosomal large subunit
The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site).
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
small ribosomal subunit
cellular_component
ribosomal small subunit
The smaller of the two subunits of a ribosome.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Nebenkern
cellular_component
A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme.
GOC:ma
http://purl.org/obo/owl/GOC#GOC_ma
mitochondrial derivative
cellular_component
The major and minor mitochondrial derivatives are the mitochondria of the sperm tail and derive by the unfolding of the Nebenkern during flagellum elongation.
GOC:ma
http://purl.org/obo/owl/GOC#GOC_ma
major mitochondrial derivative
cellular_component
The larger of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation; the major mitochondrial derivative is ovoid and darker than the minor derivative.
PMID:17123504
http://purl.org/obo/owl/PMID#PMID_17123504
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
minor mitochondrial derivative
cellular_component
The smaller of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:17123504
http://purl.org/obo/owl/PMID#PMID_17123504
dystrophin-associated glycoprotein complex
cellular_component
A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase.
PMID:16710609
http://purl.org/obo/owl/PMID#PMID_16710609
PMID:15117830
http://purl.org/obo/owl/PMID#PMID_15117830
dystrophin glycoprotein complex
DGC
dystroglycan complex
cellular_component
A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin.
PMID:15117830
http://purl.org/obo/owl/PMID#PMID_15117830
PMID:16710609
http://purl.org/obo/owl/PMID#PMID_16710609
sarcoglycan complex
cellular_component
sarcoglycan-sarcospan complex
A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex.
PMID:15117830
http://purl.org/obo/owl/PMID#PMID_15117830
PMID:16710609
http://purl.org/obo/owl/PMID#PMID_16710609
syntrophin complex
cellular_component
A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase.
URL:http://www.dmd.nl/DGC.html#syn
http://www.dmd.nl/DGC.html#syn
nitric oxide synthase-dystrophin complex, skeletal muscle
CORUM:416
http://purl.org/obo/owl/CORUM#CORUM_416
dystrobrevin complex
cellular_component
A protein complex comprising alpha- and beta-dystrobrevin; forms part of the dystrophin glycoprotein complex.
PMID:15117830
http://purl.org/obo/owl/PMID#PMID_15117830
PMID:16710609
http://purl.org/obo/owl/PMID#PMID_16710609
membrane
cellular_component
Wikipedia:Biological_membrane
http://purl.org/obo/owl/Wikipedia#Wikipedia_Biological_membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
integral to membrane
cellular_component
Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
Wikipedia:Transmembrane_protein
http://purl.org/obo/owl/Wikipedia#Wikipedia_Transmembrane_protein
transmembrane
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cytoplasmic membrane-bounded vesicle
cellular_component
A membrane-bounded vesicle found in the cytoplasm of the cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
cytoplasmic membrane-enclosed vesicle
cytoplasmic membrane bounded vesicle
inaD signaling complex
cellular_component
A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD.
PMID:9010208
http://purl.org/obo/owl/PMID#PMID_9010208
PMID:9796815
http://purl.org/obo/owl/PMID#PMID_9796815
GOC:hb
http://purl.org/obo/owl/GOC#GOC_hb
inaD signalling complex
rhabdomere
cellular_component
The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction.
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
GOC:hb
http://purl.org/obo/owl/GOC#GOC_hb
PMID:8646774
http://purl.org/obo/owl/PMID#PMID_8646774
subrhabdomeral cisterna
cellular_component
A membrane-bounded compartment that is found at the base of the rhabdomere and contains stored calcium, InsP3 receptors and smooth endoplasmic reticulum Ca2+-ATPase.
PMID:8646774
http://purl.org/obo/owl/PMID#PMID_8646774
PMID:11707492
http://purl.org/obo/owl/PMID#PMID_11707492
submicrovillar cisterna
PMID:11707492
http://purl.org/obo/owl/PMID#PMID_11707492
SMC
zeta DNA polymerase complex
cellular_component
A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer.
PMID:16971464
http://purl.org/obo/owl/PMID#PMID_16971464
PMID:16631579
http://purl.org/obo/owl/PMID#PMID_16631579
procollagen-proline 4-dioxygenase complex
cellular_component
procollagen-proline, 2-oxoglutarate-4-dioxygenase complex
EC:1.14.11.2
http://purl.org/obo/owl/EC#EC_1.14.11.2
A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase.
PMID:7753822
http://purl.org/obo/owl/PMID#PMID_7753822
PMID:14500733
http://purl.org/obo/owl/PMID#PMID_14500733
prolyl 4-hydroxylase complex
EC:1.14.11.2
http://purl.org/obo/owl/EC#EC_1.14.11.2
inclusion body
cellular_component
Wikipedia:Inclusion_bodies
http://purl.org/obo/owl/Wikipedia#Wikipedia_Inclusion_bodies
A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:11121744
http://purl.org/obo/owl/PMID#PMID_11121744
aggresome
cellular_component
An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules.
PMID:11121744
http://purl.org/obo/owl/PMID#PMID_11121744
Wikipedia:Aggresome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Aggresome
prefoldin complex
cellular_component
Wikipedia:Prefoldin
http://purl.org/obo/owl/Wikipedia#Wikipedia_Prefoldin
GIM complex
A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits.
PMID:9630229
http://purl.org/obo/owl/PMID#PMID_9630229
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:17384227
http://purl.org/obo/owl/PMID#PMID_17384227
eukaryotic translation initiation factor 4F complex
cellular_component
The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.
PMID:8449919
http://purl.org/obo/owl/PMID#PMID_8449919
GOC:hb
http://purl.org/obo/owl/GOC#GOC_hb
eukaryotic translation initiation factor 4 complex
eIF-4F
eukaryotic 43S preinitiation complex
cellular_component
A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
PMID:15145049
http://purl.org/obo/owl/PMID#PMID_15145049
eukaryotic 43S pre-initiation complex
basolateral plasma membrane
cellular_component
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
apical plasma membrane
cellular_component
The region of the plasma membrane located at the apical end of the cell.
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
apicolateral plasma membrane
cellular_component
The apical end of the lateral plasma membrane of epithelial cells.
GOC:hb
http://purl.org/obo/owl/GOC#GOC_hb
lateral plasma membrane
cellular_component
The membranes on the sides of epithelial cells which lie at the interface of adjacent cells.
GOC:hb
http://purl.org/obo/owl/GOC#GOC_hb
other collagen
This term was made obsolete because it is a redundant grouping term.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
catenin complex
cellular_component
Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton.
ISBN:0198599323
http://purl.org/obo/owl/ISBN#ISBN_0198599323
nuclear matrix
cellular_component
Wikipedia:Nuclear_matrix
http://purl.org/obo/owl/Wikipedia#Wikipedia_Nuclear_matrix
The dense fibrillar network lying on the inner side of the nuclear membrane.
ISBN:0582227089
http://purl.org/obo/owl/ISBN#ISBN_0582227089
nucleoskeleton
RNA-induced silencing complex
cellular_component
RISC complex
Wikipedia:RNA-induced_silencing_complex
http://purl.org/obo/owl/Wikipedia#Wikipedia_RNA-induced_silencing_complex
A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.
PMID:10749213
http://purl.org/obo/owl/PMID#PMID_10749213
PMID:15145345
http://purl.org/obo/owl/PMID#PMID_15145345
X chromosome located dosage compensation complex, transcription activating
cellular_component
An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster.
GOC:ma
http://purl.org/obo/owl/GOC#GOC_ma
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
dosage compensation complex
myosin complex
cellular_component
A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.
URL:http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
ISBN:96235764
http://purl.org/obo/owl/ISBN#ISBN_96235764
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
myosin II complex
cellular_component
conventional myosin
A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures.
ISBN:96235764
http://purl.org/obo/owl/ISBN#ISBN_96235764
URL:http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
unconventional myosin complex
Note that this term is retained because it is widely used by biologists.
GO:0005860
cellular_component
non-muscle myosin
A portmanteau term for myosins other than myosin II.
GOC:ma
http://purl.org/obo/owl/GOC#GOC_ma
chaperonin ATPase complex
cellular_component
Multisubunit protein complex with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts.
EC:3.6.4.9
http://purl.org/obo/owl/EC#EC_3.6.4.9
proton-transporting two-sector ATPase complex
cellular_component
hydrogen-transporting two-sector ATPase complex
A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:16691483
http://purl.org/obo/owl/PMID#PMID_16691483
ISBN:0716743663
http://purl.org/obo/owl/ISBN#ISBN_0716743663
vacuolar hydrogen-transporting ATPase
vacuolar proton-transporting V-type ATPase complex
See also the cellular component terms 'vacuolar proton-transporting V-type ATPase, V1 domain ; GO:0000221' and 'vacuolar proton-transporting V-type ATPase, V0 domain ; GO:0000220' and the molecular function term 'hydrogen ion transporting ATPase activity, rotational mechanism ; GO:0046961'.
cellular_component
A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:16449553
http://purl.org/obo/owl/PMID#PMID_16449553
ISBN:0716743663
http://purl.org/obo/owl/ISBN#ISBN_0716743663
vacuolar hydrogen-translocating V-type ATPase complex
sodium ion-transporting two-sector ATPase complex
cellular_component
A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of sodium ions across a membrane. The complex comprises a membrane sector (F0 or V0) that carries out ion transport and a cytoplasmic compartment sector (F1 or V1) that catalyzes ATP synthesis or hydrolysis.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:14656431
http://purl.org/obo/owl/PMID#PMID_14656431
sodium-transporting two-sector ATPase complex
sodium ion-transporting F-type ATPase complex
cellular_component
A sodium ion-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism.
PMID:14656431
http://purl.org/obo/owl/PMID#PMID_14656431
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
sodium-translocating F-type ATPase complex
sodium ion-transporting V-type ATPase complex
cellular_component
A sodium ion-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of sodium ions across a concentration gradient. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:15802565
http://purl.org/obo/owl/PMID#PMID_15802565
sodium-translocating V-type ATPase complex
mitochondrial fatty acid beta-oxidation multienzyme complex
cellular_component
trifunctional enzyme
fatty acid beta-oxidation multienzyme complex
GOC:imk
http://purl.org/obo/owl/GOC#GOC_imk
A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix.
GOC:ma
http://purl.org/obo/owl/GOC#GOC_ma
core-binding factor complex
cellular_component
PEPB2 complex
CBF complex
A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit.
PMID:8497254
http://purl.org/obo/owl/PMID#PMID_8497254
PMID:15156179
http://purl.org/obo/owl/PMID#PMID_15156179
AML1 complex
SWI/SNF complex
cellular_component
SWI-SNF complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A SWI/SNF-type complex that contains nine or more proteins, including both conserved (core) and nonconserved components; the Swi2/Snf2 ATPase is one of the core components.
PMID:12672490
http://purl.org/obo/owl/PMID#PMID_12672490
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
interleukin-4 receptor complex
cellular_component
A protein complex that binds interleukin-4 (IL-4) and consists of an alpha chain that binds IL-4 with high affinity and a gamma common chain that also forms part of the interleukin-2 receptor.
PMID:10358772
http://purl.org/obo/owl/PMID#PMID_10358772
IL-4 receptor complex
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
sarcoplasm
cellular_component
The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
Wikipedia:Sarcoplasm
http://purl.org/obo/owl/Wikipedia#Wikipedia_Sarcoplasm
sarcoplasmic reticulum
See also the cellular component terms 'sarcoplasm ; GO:0016528', 'nuclear envelope ; GO:0005635' and 'endoplasmic reticulum ; GO:0005783'.
cellular_component
GO:0008221
Wikipedia:Endoplasmic_reticulum#Sarcoplasmic_reticulum
http://purl.org/obo/owl/Wikipedia#Wikipedia_Endoplasmic_reticulum#Sarcoplasmic_reticulum
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
GOC:mtg_muscle
http://purl.org/obo/owl/GOC#GOC_mtg_muscle
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
ISBN:0124325653
http://purl.org/obo/owl/ISBN#ISBN_0124325653
cyclin-dependent protein kinase 5 holoenzyme complex
cellular_component
A protein complex that activates cyclin-dependent kinase 5; composed of regulatory and catalytic subunits.
PMID:15689152
http://purl.org/obo/owl/PMID#PMID_15689152
Sin3 complex
cellular_component
A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins.
PMID:11743021
http://purl.org/obo/owl/PMID#PMID_11743021
PMID:12865422
http://purl.org/obo/owl/PMID#PMID_12865422
PMID:10589671
http://purl.org/obo/owl/PMID#PMID_10589671
NuRD complex
cellular_component
An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
PMID:17289569
http://purl.org/obo/owl/PMID#PMID_17289569
PMID:11743021
http://purl.org/obo/owl/PMID#PMID_11743021
PMID:10589671
http://purl.org/obo/owl/PMID#PMID_10589671
Mi-2 complex
nucleosome remodeling and histone deacetylation complex
NRD complex
chromatin remodeling complex
cellular_component
GO:0005679
nucleosome remodeling complex
chromatin remodelling complex
Any complex that mediates dynamic changes in eukaryotic chromatin.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
RSC complex
cellular_component
A protein complex similar to, but more abundant than, the Swi/Snf complex. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining.
PMID:8980231
http://purl.org/obo/owl/PMID#PMID_8980231
PMID:15870268
http://purl.org/obo/owl/PMID#PMID_15870268
PMID:12672490
http://purl.org/obo/owl/PMID#PMID_12672490
PMID:11937489
http://purl.org/obo/owl/PMID#PMID_11937489
ISW1 complex
cellular_component
A protein complex that contains an ISWI-family ATPase such as Saccharomyces Isw1p, and acts to modify chromatin structure.
PMID:15020051
http://purl.org/obo/owl/PMID#PMID_15020051
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
NURF complex
cellular_component
A four subunit ISWI-containing protein complex that facilitates nucleosome mobility and transcriptional activation in an ATP-dependent manner. In contrast to other chromatin remodeling complexes, the ATPase activity of NURF requires nucleosomes rather than free DNA or histones.
PMID:11279013
http://purl.org/obo/owl/PMID#PMID_11279013
PMID:10779516
http://purl.org/obo/owl/PMID#PMID_10779516
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
nucleosome remodeling factor complex
ACF complex
cellular_component
A chromatin-remodeling complex that catalyzes the ATP-dependent assembly of periodic nucleosome arrays. In Drosophila, the complex comprises ACF1 and ISWI.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
PMID:12192034
http://purl.org/obo/owl/PMID#PMID_12192034
ATP-utilizing chromatin assembly and remodeling factor complex
DNA-directed RNA polymerase II, holoenzyme
cellular_component
Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA.
Wikipedia:Rna_polymerase_ii
http://purl.org/obo/owl/Wikipedia#Wikipedia_Rna_polymerase_ii
PMID:15196470
http://purl.org/obo/owl/PMID#PMID_15196470
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
mediator complex
GO:0000119
cellular_component
Srb-mediator complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
L mediator complex
Wikipedia:Mediator_(coactivator)
http://purl.org/obo/owl/Wikipedia#Wikipedia_Mediator_(coactivator)
CDK8-containing TRAP/mediator complex
A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
PMID:17870225
http://purl.org/obo/owl/PMID#PMID_17870225
PMID:16168358
http://purl.org/obo/owl/PMID#PMID_16168358
PMID:11454195
http://purl.org/obo/owl/PMID#PMID_11454195
TRAP complex
Cdc73/Paf1 complex
cellular_component
Paf1p complex
GOC:cjk
http://purl.org/obo/owl/GOC#GOC_cjk
Paf1 complex
GOC:cjk
http://purl.org/obo/owl/GOC#GOC_cjk
A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p.
PMID:11884586
http://purl.org/obo/owl/PMID#PMID_11884586
flotillin complex
See also the cellular component term 'caveola ; GO:0005901'.
cellular_component
A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae.
PMID:17206938
http://purl.org/obo/owl/PMID#PMID_17206938
PMID:17600709
http://purl.org/obo/owl/PMID#PMID_17600709
CCAAT-binding factor complex
cellular_component
A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; in Saccharomyces it activates the transcription of genes in response to growth in a nonfermentable carbon source; consists of four known subunits: HAP2, HAP3, HAP4 and HAP5.
PMID:7828851
http://purl.org/obo/owl/PMID#PMID_7828851
nuclear body
cellular_component
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
GOC:ma
http://purl.org/obo/owl/GOC#GOC_ma
PMID:10330182
http://purl.org/obo/owl/PMID#PMID_10330182
NIF_Subcellular:sao505137457
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao505137457
PML body
cellular_component
PML NB
ND10
PML nuclear body
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
GOC:ma
http://purl.org/obo/owl/GOC#GOC_ma
PMID:10944585
http://purl.org/obo/owl/PMID#PMID_10944585
nuclear dot
LYSP100-associated nuclear domain
cellular_component
LANDs
PMID:8695863
http://purl.org/obo/owl/PMID#PMID_8695863
A nuclear body that is enriched in the lymphoid cell-specific protein LYSp100B; LANDs are globular, electron-dense structures and are morphologically distinct from the annular structures characteristic of PML bodies.
PMID:8695863
http://purl.org/obo/owl/PMID#PMID_8695863
PMID:10921892
http://purl.org/obo/owl/PMID#PMID_10921892
nuclear speck
cellular_component
splicing speckle
nuclear speckles
nuclear speckle
speckle domain
speckle focus
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
URL:http://www.cellnucleus.com/
http://www.cellnucleus.com/
nitrogenase complex
cellular_component
An enzyme complex composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase is tetrameric with an alpha2-beta2 structure and nitrogenase reductase is a homodimer, and both are associated with metal ions, which differ between species. Both proteins are required for the enzyme activity of the complex, the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen.
MetaCyc:CPLX-525
http://purl.org/obo/owl/MetaCyc#MetaCyc_CPLX-525
MetaCyc:CPLX-186
http://purl.org/obo/owl/MetaCyc#MetaCyc_CPLX-186
EC:1.18.6.1
http://purl.org/obo/owl/EC#EC_1.18.6.1
iron-iron nitrogenase complex
Note that it is not established whether the nitrogenase exists in vivo in a specific particle or whether the nitrogenase proteins are bound nonspecifically to the membranes of some cells.
cellular_component
An enzyme complex containing an iron-iron cluster found in species such as the photosynthetic bacterium Rhodobacter capsulatus. It is composed of two main subunits, dinitrogenase and nitrogenase reductase. Dinitrogenase, the iron-iron containing subunit, has an alpha1-beta2 or alpha2-beta2 structure, and the nitrogenase reductase subunit is a homodimer. Functions in the catalysis of the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen.
EC:1.18.6.1
http://purl.org/obo/owl/EC#EC_1.18.6.1
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:11848850
http://purl.org/obo/owl/PMID#PMID_11848850
molybdenum-iron nitrogenase complex
cellular_component
An enzyme complex containing a molybdenum-iron cluster found in many species. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the molybdenum-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer.
EC:1.18.6.1
http://purl.org/obo/owl/EC#EC_1.18.6.1
molybdenum-iron nitrogenase activity
vanadium-iron nitrogenase complex
cellular_component
vanadium-iron nitrogenase activity
An enzyme complex containing a vanadium-iron cluster found in some species, such as Azotobacter vinelandii. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the vanadium-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer.
EC:1.18.6.1
http://purl.org/obo/owl/EC#EC_1.18.6.1
PMID:3474027
http://purl.org/obo/owl/PMID#PMID_3474027
follicle-stimulating hormone complex
cellular_component
follicle stimulating hormone complex
A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland; consists of alpha and beta subunits, the latter of which confers hormonal specificity.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
FSH complex
glycine-gated chloride channel complex
cellular_component
A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
kinesin I complex
cellular_component
A complex of two kinesin heavy chains and two kinesin light chains.
URL:http://www.csfic.mi.cnr.it/centro/lines/8/ric.html
http://www.csfic.mi.cnr.it/centro/lines/8/ric.html
kinesin II complex
cellular_component
A complex consisting of two distinct motor subunits that form a heterodimer complexed with a third non-motor accessory subunit, the kinesin associated protein or KAP; the KIF3 heterodimer interacts via its C-terminal portion with KAP, which is thought to regulate the binding of the motor to cargo membranes.
URL:http://www.csfic.mi.cnr.it/centro/lines/8/ric.html
http://www.csfic.mi.cnr.it/centro/lines/8/ric.html
insulin-like growth factor binding protein complex
cellular_component
A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
IGF binding protein complex
myosin phosphatase complex
cellular_component
An enzyme complex that catalyzes the removal of the phosphate group from phosphomyosin.
EC:3.1.3.16
http://purl.org/obo/owl/EC#EC_3.1.3.16
insulin-like growth factor binding protein
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
transcriptional repressor complex
cellular_component
A protein complex that possesses activity that prevents or downregulates transcription.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
negative cofactor 2 complex
cellular_component
A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini.
PMID:15574413
http://purl.org/obo/owl/PMID#PMID_15574413
serine C-palmitoyltransferase complex
cellular_component
An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine.
EC:2.3.1.50
http://purl.org/obo/owl/EC#EC_2.3.1.50
intracellular cyclic nucleotide activated cation channel complex
cellular_component
A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex
cellular_component
GO:0031212
A protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamine diphosphate; the enzyme also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxo-pentanoate.
EC:1.2.4.4
http://purl.org/obo/owl/EC#EC_1.2.4.4
BCADH
branched-chain alpha-ketoacid dehydrogenase complex
mitochondrial processing peptidase complex
Note that monomeric mitochondrial processing peptidases have been observed.
cellular_component
A protein complex that consists of a catalytic alpha subunit (alpha-MPP) and a regulatory beta subunit (beta-MPP), and catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion.
BRENDA:3.4.24.64
http://purl.org/obo/owl/BRENDA#BRENDA_3.4.24.64
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
EC:3.4.24.64
http://purl.org/obo/owl/EC#EC_3.4.24.64
meprin A complex
cellular_component
PABA peptide hydrolase complex
A protein complex that is located in the cell membrane, and is involved in the metabolism of peptides, including neuropeptides. The complex has metalloendopeptidase activity that catalyzes the hydrolysis of protein and peptide substrates, preferentially on carboxyl side of hydrophobic residues.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
MEROPS_fam:M12
http://purl.org/obo/owl/MEROPS_fam#MEROPS_fam_M12
EC:3.4.24.18
http://purl.org/obo/owl/EC#EC_3.4.24.18
aminoacyl-tRNA synthetase multienzyme complex
cellular_component
aminoacyl-tRNA synthetase complex
multisynthetase complex
A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:16169847
http://purl.org/obo/owl/PMID#PMID_16169847
methionyl glutamyl tRNA synthetase complex
cellular_component
A complex consisting of methionyl- and glutamyl-tRNA synthetases. The tRNA synthetases present in the complex bind to their cognate tRNAs more efficiently than they do as monomers.
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
PMID:11069915
http://purl.org/obo/owl/PMID#PMID_11069915
glutamate-cysteine ligase complex
cellular_component
gamma-glutamylcysteine synthetase complex
An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine.
EC:6.3.2.2
http://purl.org/obo/owl/EC#EC_6.3.2.2
single-stranded DNA-dependent ATP-dependent DNA helicase complex
cellular_component
A protein complex that possesses single-stranded DNA-dependent DNA helicase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ssDNA-dependent ATP-dependent DNA helicase complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Golgi transport complex
cellular_component
A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p).
PMID:9792665
http://purl.org/obo/owl/PMID#PMID_9792665
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
conserved oligomeric Golgi complex
COG complex
Sec34/35 complex
protein N-acetylglucosaminyltransferase complex
cellular_component
Heterotrimeric enzyme complex, which in humans is composed of two large subunits of the same size, and one smaller subunit. Functions in the addition of nucleotide-activated sugars onto the polypeptide.
PMID:15247246
http://purl.org/obo/owl/PMID#PMID_15247246
UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
O-GlcNAc transferase complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mitochondrial electron transfer flavoprotein complex
cellular_component
A protein complex located in the mitochondrion. It contains flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
N-methyl-D-aspartate selective glutamate receptor complex
cellular_component
NMDA-selective glutamate receptor
An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD.
URL:http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html
http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html
glucosidase II complex
Note that alpha-glucosidase I functions as a monomer, and therefore does not have a corresponding cellular component term.
cellular_component
A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins.
PMID:8910335
http://purl.org/obo/owl/PMID#PMID_8910335
PMID:10464333
http://purl.org/obo/owl/PMID#PMID_10464333
alpha-glucosidase II complex
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
GOC:19605557
http://purl.org/obo/owl/GOC#GOC_19605557
translation release factor complex
cellular_component
peptide chain release factor
A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
eukaryotic peptide chain release factor
host
cellular_component
Any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
host organism
Wikipedia:Host_(biology)
http://purl.org/obo/owl/Wikipedia#Wikipedia_Host_(biology)
metaxin
This term was made obsolete because it represents a single gene product and not a complex.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
SCF ubiquitin ligase complex
cellular_component
A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
PMID:15571813
http://purl.org/obo/owl/PMID#PMID_15571813
PMID:15688063
http://purl.org/obo/owl/PMID#PMID_15688063
Skp1/Cul1/F-box protein complex
Wikipedia:SCF_complex
http://purl.org/obo/owl/Wikipedia#Wikipedia_SCF_complex
SCF complex substrate recognition subunit
cullin-RING ligase 1
Cul1-RING ubiquitin ligase complex
SCF complex
CRL1 complex
CDL1 complex
molybdopterin synthase complex
GO:0019009
cellular_component
molybdopterin converting factor complex
A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:12571227
http://purl.org/obo/owl/PMID#PMID_12571227
PMID:15709772
http://purl.org/obo/owl/PMID#PMID_15709772
virion
cellular_component
The complete fully infectious extracellular virus particle.
ISBN:0781718325
http://purl.org/obo/owl/ISBN#ISBN_0781718325
complete virus particle
Wikipedia:Virus
http://purl.org/obo/owl/Wikipedia#Wikipedia_Virus
viral nucleocapsid
GO:0019014
cellular_component
nucleocapsid
The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle.
ISBN:0781702534
http://purl.org/obo/owl/ISBN#ISBN_0781702534
core
viral genome
cellular_component
The whole of the genetic information of a virus, contained as either DNA or RNA.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
non-segmented viral genome
cellular_component
A viral genome that consists of one continuous nucleic acid molecule.
GOC:pk
http://purl.org/obo/owl/GOC#GOC_pk
segmented viral genome
cellular_component
A viral genome that is divided into two or more physically separate molecules of nucleic acid and packaged into a single virion.
ISBN:0121585336
http://purl.org/obo/owl/ISBN#ISBN_0121585336
bipartite viral genome
cellular_component
A segmented viral genome consisting of two sub-genomic nucleic acids but each nucleic acid is packaged into a different virion.
ISBN:0121585336
http://purl.org/obo/owl/ISBN#ISBN_0121585336
tripartite viral genome
cellular_component
A segmented viral genome consisting of three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion.
ISBN:0121585336
http://purl.org/obo/owl/ISBN#ISBN_0121585336
multipartite viral genome
cellular_component
A segmented viral genome consisting of more than three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion.
ISBN:0121585336
http://purl.org/obo/owl/ISBN#ISBN_0121585336
DNA viral genome
cellular_component
A viral genome composed of deoxyribonucleic acid.
ISBN:0121585336
http://purl.org/obo/owl/ISBN#ISBN_0121585336
RNA viral genome
cellular_component
A viral genome composed of ribonucleic acid. This results in genome replication and expression of genetic information being inextricably linked.
ISBN:0121585336
http://purl.org/obo/owl/ISBN#ISBN_0121585336
dsRNA viral genome
cellular_component
A viral genome composed of double stranded RNA.
ISBN:0121585336
http://purl.org/obo/owl/ISBN#ISBN_0121585336
ssRNA viral genome
cellular_component
A viral genome composed of single stranded RNA of either positive or negative sense.
ISBN:0121585336
http://purl.org/obo/owl/ISBN#ISBN_0121585336
positive sense viral genome
cellular_component
A single stranded RNA genome with the same nucleotide polarity as mRNA.
ISBN:0121585336
http://purl.org/obo/owl/ISBN#ISBN_0121585336
negative sense viral genome
cellular_component
A single stranded RNA genome with the opposite nucleotide polarity as mRNA.
ISBN:0121585336
http://purl.org/obo/owl/ISBN#ISBN_0121585336
ambisense viral genome
cellular_component
A RNA genome that contains coding regions that are either positive sense or negative sense on the same RNA molecule.
ISBN:0121585336
http://purl.org/obo/owl/ISBN#ISBN_0121585336
viral capsid
cellular_component
GO:0046728
Wikipedia:Capsid
http://purl.org/obo/owl/Wikipedia#Wikipedia_Capsid
The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
helical viral capsid
cellular_component
The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form a protein helix with the genetic material contained within. Tobacco mosaic virus has such a capsid structure.
ISBN:071673706X
http://purl.org/obo/owl/ISBN#ISBN_071673706X
icosahedral viral capsid
cellular_component
The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form an icosahedron, a solid with 20 faces and 12 vertices. Tobacco satellite necrosis virus has such a capsid structure.
ISBN:071673706X
http://purl.org/obo/owl/ISBN#ISBN_071673706X
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
quasispherical viral capsid
viral envelope
cellular_component
The lipid bilayer and associated glycoproteins that surround many types of virus particle.
ISBN:0781718325
http://purl.org/obo/owl/ISBN#ISBN_0781718325
viral membrane
Wikipedia:Viral_envelope
http://purl.org/obo/owl/Wikipedia#Wikipedia_Viral_envelope
viral glycoprotein
viral glycoprotein
This term was made obsolete because it represents a type of gene product and not a location or complex.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
viral tegument
cellular_component
A structure lying between the capsid and envelope of a virus, varying in thickness and often distributed asymmetrically.
ISBN:0721662544
http://purl.org/obo/owl/ISBN#ISBN_0721662544
Wikipedia:Viral_tegument
http://purl.org/obo/owl/Wikipedia#Wikipedia_Viral_tegument
viral replication complex
cellular_component
Specific locations and structures in the virus infected cell involved in replicating the viral genome.
ISBN:0781718325
http://purl.org/obo/owl/ISBN#ISBN_0781718325
viral integration complex
cellular_component
Virus-specific complex of protein required for integrating viral genomes into the host genome.
ISBN:0781718325
http://purl.org/obo/owl/ISBN#ISBN_0781718325
viral transcriptional complex
cellular_component
Specific locations and structures in the virus infected cell involved in transcribing the viral genome.
ISBN:0781718325
http://purl.org/obo/owl/ISBN#ISBN_0781718325
viral assembly intermediate
cellular_component
Specific locations and structures in the virus infected cell involved in assembling new virions.
ISBN:0781718325
http://purl.org/obo/owl/ISBN#ISBN_0781718325
provirus
cellular_component
The name given to a viral genome after it has been integrated into the host genome; particularly applies to retroviruses and is a required part of the retroviral replication cycle.
ISBN:0121585336
http://purl.org/obo/owl/ISBN#ISBN_0121585336
Wikipedia:Provirus
http://purl.org/obo/owl/Wikipedia#Wikipedia_Provirus
histamine-gated chloride channel complex
cellular_component
A protein complex that forms a transmembrane channel through which chloride ions may pass in response to histamine binding to the channel complex or one of its constituent parts.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
snRNA-activating protein complex
cellular_component
SNAPc
A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters.
PMID:9003788
http://purl.org/obo/owl/PMID#PMID_9003788
PMID:7715707
http://purl.org/obo/owl/PMID#PMID_7715707
phosphoenolpyruvate-dependent sugar phosphotransferase complex
cellular_component
Includes phosphoenolpyruvate-protein phosphatase (enzyme I of the phosphotransferase system) and protein-N(PI)-phosphohistidine-sugar phosphotransferase (enzyme II of the phosphotransferase system).
GOC:ma
http://purl.org/obo/owl/GOC#GOC_ma
synaptosome
Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. It is advised that this term should only be used in a manual annotation statement where it is possible to apply an experimental evidence code and only if no other experimental evidence exists for an equivalent in vivo subcellular location.
cellular_component
Wikipedia:Synaptosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Synaptosome
Any of the discrete particles (nerve-ending particles) formed from the clublike presynaptic nerve endings that resist disruption and are snapped or torn off their attachments when brain tissue is homogenized in media isosmotic to plasma.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
rough microsome
Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. It is advised that this term should only be used in a manual annotation statement where it is possible to apply an experimental evidence code and only if no other experimental evidence exists for an equivalent in vivo subcellular location.
cellular_component
Vesicular particles formed from disrupted endoplasmic reticulum membranes and studded with ribosomes on the outside.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
smooth microsome
Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. It is advised that this term should only be used in a manual annotation statement where it is possible to apply an experimental evidence code and only if no other experimental evidence exists for an equivalent in vivo subcellular location.
cellular_component
Vesicular particles formed from disrupted endoplasmic reticulum and plasma membranes without any adhering ribosomes.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
proteasome core complex, alpha-subunit complex
cellular_component
The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus.
PMID:10854779
http://purl.org/obo/owl/PMID#PMID_10854779
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
proteasome core complex, beta-subunit complex
cellular_component
The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:10854779
http://purl.org/obo/owl/PMID#PMID_10854779
quinolinate synthetase complex
This term was made obsolete because there is no evidence that a physical complex forms; although the phrase "quinolinate synthetase complex" is occasionally used in the literature, it refers to two enzymes that act as monomers.
cellular_component
OBSOLETE. A heterodimer which acts as a quinolinate synthetase; quinolinate synthetase B (L-aspartate oxidase) catalyzes the oxidation of L-aspartate to L-iminoaspartate; quinolinate synthetase A condenses L-imidoaspartate and dihydroxyacetone to quinolinate.
UniProtKB:P10902
http://purl.org/obo/owl/UniProtKB#UniProtKB_P10902
Type I site-specific deoxyribonuclease complex
cellular_component
Type I restriction enzyme complex
A multisubunit complex composed of two copies of a restriction (R) subunit, two copies of a methylation (M) subunit, and one copy of a specificity (S) subunit. This complex recognizes specific short DNA sequences (through the S subunit), and binds to them. If the recognition site is hemimethylated, the complex acts as a methyltransferase which modifies the recognition site, using S-adenosylmethionine as the methyl donor. Only the M and S subunits are required for this reaction. If the complex binds to an unmethylated recognition site, then the complex translocates the DNA bidirectionally in an ATP-dependent manner. When the translocation is stalled by impact with another complex or unusual DNA structure, the enzyme functions as an endonuclease and cleavage of the DNA will occur, hundreds or thousands of base pairs away from the recognition site. These DNA restriction systems are used by bacteria to defend against phage and other foreign DNA that may enter a cell.
PMID:12654995
http://purl.org/obo/owl/PMID#PMID_12654995
PMID:15788748
http://purl.org/obo/owl/PMID#PMID_15788748
Type III site-specific deoxyribonuclease complex
cellular_component
Type III restriction enzyme complex
A heterodimeric enzyme complex composed of two subunits, Res and Mod, that functions as an endonuclease and cleaves DNA. Cleavage will only occur when there are two un-methylated copies of a specific recognition site in an inverse orientation on the DNA. Cleavage occurs at a specific distance away from one of the recognition sites. The Mod subunit can act alone as a methyltansferase. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell.
PMID:12654995
http://purl.org/obo/owl/PMID#PMID_12654995
immunoglobulin complex
Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
cellular_component
A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
B cell receptor complex
Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
cellular_component
GO:0042570
antibody
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
immunoglobulin complex, membrane bound
BCR complex
B-lymphocyte receptor complex
An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
ISBN:0781735149
http://purl.org/obo/owl/ISBN#ISBN_0781735149
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
B-cell receptor complex
B lymphocyte receptor complex
B cell receptor accessory molecule complex
B cell receptor accessory molecule complex
This term was made obsolete because it represents a molecule and not a location or complex.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
P1 peroxisome
Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
cellular_component
peroxisome vesicle
A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P1 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they contain fewer peroxisomal proteins than the other subforms.
PMID:10629216
http://purl.org/obo/owl/PMID#PMID_10629216
P2 peroxisome
Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
cellular_component
peroxisome vesicle
A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P2 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they are the least dense of the subforms observed.
PMID:10629216
http://purl.org/obo/owl/PMID#PMID_10629216
P3 peroxisome
Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
cellular_component
peroxisome vesicle
A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P3 peroxisomes are formed by fusion of P1 and P2 peroxisomes, and are distinguished from the other subforms on the bases of buoyant density and protein content.
PMID:10629216
http://purl.org/obo/owl/PMID#PMID_10629216
P4 peroxisome
Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
cellular_component
peroxisome vesicle
A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P4 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content.
PMID:10629216
http://purl.org/obo/owl/PMID#PMID_10629216
P5 peroxisome
Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P6 peroxisome ; GO:0019824'.
cellular_component
peroxisome vesicle
A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P5 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content.
PMID:10629216
http://purl.org/obo/owl/PMID#PMID_10629216
P6 peroxisome
Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P5 peroxisome ; GO:0019823'.
cellular_component
peroxisome vesicle
A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P6 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content, and are equivalent to mature peroxisomes.
PMID:10629216
http://purl.org/obo/owl/PMID#PMID_10629216
flagellum
GO:0008223
cellular_component
Long whiplike or feathery structures borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium.
UniProtKB-KW:KW-0282
http://purl.org/obo/owl/UniProtKB-KW#UniProtKB-KW_KW-0282
Wikipedia:Flagellum
http://purl.org/obo/owl/Wikipedia#Wikipedia_Flagellum
organelle inner membrane
See also the cellular component term 'outer membrane ; GO:0019867'.
cellular_component
The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
outer membrane
cellular_component
The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
extrinsic to plasma membrane
cellular_component
GO:0000157
Loosely bound to one surface of the plasma membrane, but not integrated into the hydrophobic region.
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
juxtamembrane
peripheral plasma membrane protein
extrinsic to membrane
Note that proteins extrinsic to membranes can be removed by treatments that do not disrupt the membrane, such as salt solutions.
GO:0030396
cellular_component
Wikipedia:Peripheral_membrane_protein
http://purl.org/obo/owl/Wikipedia#Wikipedia_Peripheral_membrane_protein
Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
peripheral membrane protein
cyclin-dependent protein kinase activating kinase holoenzyme complex
cellular_component
A protein complex that phosphorylates cyclin-dependent kinases such as Cdc2 on Thr161 (or an equivalent residue); contains a catalytic subunit and a regulatory subunit, and some examples also include an assembly factor.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:8752210
http://purl.org/obo/owl/PMID#PMID_8752210
CDK-activating kinase complex
CAK complex
nuclear cyclin-dependent protein kinase holoenzyme complex
cellular_component
Cyclin-dependent protein kinase (CDK) complex found in the nucleus.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
CDK holoenzyme
mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex
See also the cellular component term 'mitochondrial pyruvate dehydrogenase complex ; GO:0005967'.
cellular_component
A mitochondrial complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. An example of this component is found in Mus musculus.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:9395502
http://purl.org/obo/owl/PMID#PMID_9395502
host cell plasma membrane
cellular_component
The plasma membrane surrounding a host cell.
GOC:mb
http://purl.org/obo/owl/GOC#GOC_mb
symbiont-containing vacuole
Note that this term does not have a relationship to 'vacuole ; GO:0005773' because it does not fit the definition of a vacuole; the parasitophorous vacuole was so named because it resembles a vacuole in the microscope.
cellular_component
parasitophorous vacuole
Membrane-bounded vacuole within a host cell in which a symbiont organism resides. The vacuole membrane is derived from both the host and symbiont.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
GOC:mb
http://purl.org/obo/owl/GOC#GOC_mb
symbiont-containing vacuolar space
cellular_component
The space between a symbiont plasma membrane and the symbiont-containing vacuole membrane.
GOC:mb
http://purl.org/obo/owl/GOC#GOC_mb
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
symbiont-containing vacuole space
parasitophorous vacuolar space
symbiont-containing vacuole membrane
cellular_component
parasitophorous vacuolar membrane
The lipid bilayer surrounding a symbiont-containing vacuole, derived from both the host and symbiont.
GOC:mb
http://purl.org/obo/owl/GOC#GOC_mb
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
symbiont-containing vacuolar membrane network
cellular_component
parasitophorous vacuolar membrane network
symbiont-containing vacuole membrane network
tubulovesicular network
Tubular network of extensions from the symbiont-containing vacuole membrane that protrude into the host cytoplasm.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:3528173
http://purl.org/obo/owl/PMID#PMID_3528173
apical complex
cellular_component
A group of cytoskeletal structures and associated membrane-bounded organelles found at the anterior end of adult obligate intracellular protozoan parasites in the phylum Apicomplexa. The apical complex is involved in attachment to and penetration of the host cell, and in parasite proliferation.
GOC:mb
http://purl.org/obo/owl/GOC#GOC_mb
PMID:16518471
http://purl.org/obo/owl/PMID#PMID_16518471
rhoptry
cellular_component
Wikipedia:Rhoptry
http://purl.org/obo/owl/Wikipedia#Wikipedia_Rhoptry
toxoneme
paired organelles
A large, club-shaped secretory organelle that forms part of the apical complex of an apicomplexan parasite, and consists of a bulbous body and a narrow electron-dense neck that extends through the conoid at the apical tip of the parasite. The rhoptry necks serve as ducts through which the contents of the rhoptries are secreted after attachment to the host has been completed and at the commencement of invasion. Rhoptry proteins function in the biogenesis and host organellar association of the parasitophorous vacuole.
PMID:16002398
http://purl.org/obo/owl/PMID#PMID_16002398
PMID:11801218
http://purl.org/obo/owl/PMID#PMID_11801218
ISBN:0521664470
http://purl.org/obo/owl/ISBN#ISBN_0521664470
microneme
cellular_component
A small, elongated secretory organelle that forms part of the apical complex, located along the main axis of an apicomplexan parasite cell within the extreme apical region and at the periphery under the inner membrane complex. Of the specialized secretory compartments identified in apicomplexans, micronemes discharge their contents first, during initial contact of the parasite's apical pole with the host cell surface. Micronemal proteins function during parasite attachment and penetration into the target cell.
PMID:11801218
http://purl.org/obo/owl/PMID#PMID_11801218
ISBN:0521664470
http://purl.org/obo/owl/ISBN#ISBN_0521664470
Wikipedia:Microneme
http://purl.org/obo/owl/Wikipedia#Wikipedia_Microneme
sarconeme
conoid
cellular_component
A spiral cytoskeletal structure located at the apical end of the apical complex in some apicomplexan parasites. Fibers form a left-handed spiral, and are comprised of tubulin protofilaments organized in a ribbon-like structure that differs from the conventional tubular structure characteristic of microtubules.
GOC:expert_dr
http://purl.org/obo/owl/GOC#GOC_expert_dr
PMID:11901169
http://purl.org/obo/owl/PMID#PMID_11901169
PMID:16518471
http://purl.org/obo/owl/PMID#PMID_16518471
apicoplast
cellular_component
The plastid organelle found in apicomplexans.
ISBN:0521664470
http://purl.org/obo/owl/ISBN#ISBN_0521664470
Wikipedia:Apicoplast
http://purl.org/obo/owl/Wikipedia#Wikipedia_Apicoplast
glycosome
cellular_component
A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis.
GOC:mb
http://purl.org/obo/owl/GOC#GOC_mb
Wikipedia:Glycosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Glycosome
flagellar pocket
cellular_component
Invagination of the plasma membrane from which a flagellum protrudes.
GOC:mb
http://purl.org/obo/owl/GOC#GOC_mb
flagellar membrane
cellular_component
The portion of the plasma membrane surrounding the flagellum.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:mb
http://purl.org/obo/owl/GOC#GOC_mb
flagellar pocket membrane
cellular_component
That part of the plasma membrane found in the flagellar pocket.
GOC:mb
http://purl.org/obo/owl/GOC#GOC_mb
food vacuole
GO:0005772
cellular_component
digestive vacuole
Vacuole within a parasite used for digestion of the host cell cytoplasm. An example of this component is found in the Apicomplexa.
GOC:mb
http://purl.org/obo/owl/GOC#GOC_mb
acidocalcisome
cellular_component
volutin granule
PMID:15738951
http://purl.org/obo/owl/PMID#PMID_15738951
An electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations.
GOC:mb
http://purl.org/obo/owl/GOC#GOC_mb
metachromatic granule
PMID:15738951
http://purl.org/obo/owl/PMID#PMID_15738951
polyphosphate vacuole
PMID:15738951
http://purl.org/obo/owl/PMID#PMID_15738951
kinetoplast
cellular_component
A sub-structure within the large single mitochondrion of kinetoplastid parasites and which is closely associated with the flagellar pocket and basal body of the flagellum.
GOC:mb
http://purl.org/obo/owl/GOC#GOC_mb
Wikipedia:Kinetoplast
http://purl.org/obo/owl/Wikipedia#Wikipedia_Kinetoplast
subpellicular microtubule
cellular_component
Singlet microtubules that lie underneath the inner membrane complex and emanate from the basal ring of the conoid.
GOC:mb
http://purl.org/obo/owl/GOC#GOC_mb
merozoite dense granule
cellular_component
dense body
Electron-dense organelle with a granular internal matrix found throughout the merozoite life cycle stage of apicomplexan parasites; contains proteins destined to be secreted into the parasitophorous vacuole following parasite invasion of a host cell.
GOC:mb
http://purl.org/obo/owl/GOC#GOC_mb
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
infected host cell surface knob
cellular_component
Protrusion that develops in the plasma membrane of a parasitized erythrocyte. An example of this component is found in Plasmodium species.
GOC:mb
http://purl.org/obo/owl/GOC#GOC_mb
polar ring of apical complex
cellular_component
An electron dense ring at the most anterior position of the apical complex, from which the conoid fibers originate; formed during an invasive life cycle stage of an apicomplexan parasite.
PMID:16518471
http://purl.org/obo/owl/PMID#PMID_16518471
GOC:mb
http://purl.org/obo/owl/GOC#GOC_mb
upper polar ring of apical complex
anterior polar ring of apical complex
basal ring of apical complex
cellular_component
posterior polar ring of apical complex
lower polar ring of apical complex
An electron dense ring at the most posterior position of the apical complex, from which the subpellicular microtubules originate; formed during an invasive life cycle stage of an apicomplexan parasite.
PMID:16518471
http://purl.org/obo/owl/PMID#PMID_16518471
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
preconoidal ring of apical complex
Maurer's cleft
cellular_component
A disk-like structure that appears at the periphery of a red blood cell infected by an apicomplexan parasite, characterized by a translucent lumen and an electron-dense coat of variable thickness; often appears to be tethered to the host cell membrane by fibrous connections with the erythrocyte cytoskeleton.
PMID:16705161
http://purl.org/obo/owl/PMID#PMID_16705161
Maurers cleft
subpellicular network
cellular_component
A mechanically stable cytoskeletal structure associated with the cytoplasmic face of the pellicle and surrounding the microtubule-based cytoskeleton.
PMID:11420112
http://purl.org/obo/owl/PMID#PMID_11420112
pellicle
cellular_component
The structure enclosing an apicomplexan parasite cell; consists of the cell membrane with its associated infrastructure of microtubules, microfilaments and other organelles.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:mb
http://purl.org/obo/owl/GOC#GOC_mb
proteasome-activating nucleotidase complex
cellular_component
PAN
A multisubunit complex that recognizes and unfolds core proteasome substrate proteins, and translocates them to the core complex in an ATP dependent manner.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
proteasome accessory complex
cellular_component
A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
cytosolic large ribosomal subunit
GO:0030498
GO:0005842
cellular_component
GO:0009282
GO:0030872
The large subunit of a ribosome located in the cytosol.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
prokaryotic large ribosomal subunit
eukaryotic ribosomal LSU
60S ribosomal subunit
50S ribosomal subunit
cytosolic ribosome
GO:0030871
GO:0005830
cellular_component
GO:0009281
80S ribosome
A ribosome located in the cytosol.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
70S ribosome
cytosolic small ribosomal subunit
GO:0030873
GO:0005843
cellular_component
GO:0030499
GO:0009283
30S ribosomal subunit
The small subunit of a ribosome located in the cytosol.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
prokaryotic small ribosomal subunit
40S ribosomal subunit
eukaryotic ribosomal SSU
chloroplast large ribosomal subunit
cellular_component
chloroplast ribosomal LSU complex
The large subunit of a ribosome contained within a chloroplast.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
chloroplast ribosomal large subunit complex
chloroplast small ribosomal subunit
cellular_component
The small subunit of a ribosome contained within a chloroplast.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
chloroplast ribosomal SSU complex
chloroplast ribosomal small subunit complex
TRAPP complex
cellular_component
TRAPP2
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
TRAPP1
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
transport protein particle
A large complex present on the cis-Golgi that acts prior to SNARE complex assembly to mediate vesicle docking and fusion. Ras guanyl-nucleotide exchange factor activity has been demonstrated for this complex in S. cerevisiae.
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:17287728
http://purl.org/obo/owl/PMID#PMID_17287728
PMID:9564032
http://purl.org/obo/owl/PMID#PMID_9564032
Wikipedia:TRAPP_complex
http://purl.org/obo/owl/Wikipedia#Wikipedia_TRAPP_complex
CCR4-NOT complex
cellular_component
The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins.
PMID:11113136
http://purl.org/obo/owl/PMID#PMID_11113136
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
CCR4-NOT core complex
cellular_component
The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p.
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
PMID:11113136
http://purl.org/obo/owl/PMID#PMID_11113136
myofibril
cellular_component
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
Wikipedia:Myofibril
http://purl.org/obo/owl/Wikipedia#Wikipedia_Myofibril
striated muscle fibre
striated muscle fiber
sarcomere
cellular_component
Wikipedia:Sarcomere
http://purl.org/obo/owl/Wikipedia#Wikipedia_Sarcomere
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
Z disc
cellular_component
Z band
Z disk
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
GOC:mtg_muscle
http://purl.org/obo/owl/GOC#GOC_mtg_muscle
Z line
lamellipodium
cellular_component
Wikipedia:Lamellipodia
http://purl.org/obo/owl/Wikipedia#Wikipedia_Lamellipodia
A thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
cell junction
cellular_component
Wikipedia:Cell_junction
http://purl.org/obo/owl/Wikipedia#Wikipedia_Cell_junction
A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
URL:http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html
http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
cell-substrate junction
cellular_component
cell-matrix junction
A cell junction that forms a connection between a cell and the extracellular matrix.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:hb
http://purl.org/obo/owl/GOC#GOC_hb
hemidesmosome
cellular_component
Wikipedia:Hemidesmosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Hemidesmosome
A cell-substrate junction that forms a point of contact between the basal surface of epithelial cells and the basal lamina. Morphologically resembles desmosomes; attached to intermediate filaments.
ISBN:0815316208
http://purl.org/obo/owl/ISBN#ISBN_0815316208
hemi-adherens junction
URL:http://www.wormatlas.org/glossaries/hglossary.htm#hemiadherensjunction
http://www.wormatlas.org/glossaries/hglossary.htm#hemiadherensjunction
desmosome
cellular_component
macula adherens
spot desmosome
A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0815332181
http://purl.org/obo/owl/ISBN#ISBN_0815332181
GOC:mtg_muscle
http://purl.org/obo/owl/GOC#GOC_mtg_muscle
Wikipedia:Desmosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Desmosome
mitochondrial crista
See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
cellular_component
mitochondrial cristae
NIF_Subcellular:sao333328131
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao333328131
Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
mitochondrial tricarboxylic acid cycle enzyme complex
cellular_component
Any of the heteromeric enzymes, located in the mitochondrion, that act in the tricarboxylic acid (TCA) cycle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
TCA cycle enzyme complex
murein sacculus
This term was made obsolete because it was defined inaccurately.
cellular_component
OBSOLETE. A structure formed of the cross-linked polymer peptidoglycan (also called murein) that forms a covalently closed net around a bacterial cell, and imparts structural stability to the bacterial cell wall.
PMID:9529891
http://purl.org/obo/owl/PMID#PMID_9529891
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
peptidoglycan layer
cell wall inner membrane
This term was made obsolete because it was defined inaccurately.
cellular_component
OBSOLETE. The peptidoglycan layer of the cell wall of Gram-negative bacteria.
ISBN:0135712254
http://purl.org/obo/owl/ISBN#ISBN_0135712254
thylakoid (sensu Proteobacteria)
This term was made obsolete because thylakoids are not found in organisms of the Phylum Proteobacteria.
cellular_component
OBSOLETE. A thylakoid; as in, but not restricted to, the purple bacteria and relatives (Proteobacteria, ncbi_taxonomy_id:1224).
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
plasma membrane-derived thylakoid
cellular_component
A thylakoid that is derived from and attached to, but not necessarily continuous with, the plasma membrane, and is not enclosed in a plastid. It bears the photosynthetic pigments in photosynthetic cyanobacteria.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
light-harvesting complex
cellular_component
antenna complex
Wikipedia:Light-harvesting_complex
http://purl.org/obo/owl/Wikipedia#Wikipedia_Light-harvesting_complex
A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center.
GOC:lr
http://purl.org/obo/owl/GOC#GOC_lr
plasma membrane light-harvesting complex
cellular_component
A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
light-harvesting complex, core complex
cellular_component
Light harvesting complex associated with the reaction complex of photosynthetic purple bacteria.
GOC:lr
http://purl.org/obo/owl/GOC#GOC_lr
light-harvesting complex, peripheral complex
cellular_component
Bacteriochlorophyll a binding complex that is peripherally associated to the bacterial reaction center.
GOC:lr
http://purl.org/obo/owl/GOC#GOC_lr
B875 antenna complex
cellular_component
LH1 complex
light harvesting complex I
Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm.
GOC:kd
http://purl.org/obo/owl/GOC#GOC_kd
B800-820 antenna complex
cellular_component
light harvesting complex III
Protein-pigment complex that absorbs light at 800 and 820 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex.
GOC:kd
http://purl.org/obo/owl/GOC#GOC_kd
GOC:lr
http://purl.org/obo/owl/GOC#GOC_lr
LH3 complex
B800-850 antenna complex
cellular_component
Protein-pigment complex that absorbs light at 800 and 850 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex.
GOC:lr
http://purl.org/obo/owl/GOC#GOC_lr
GOC:kd
http://purl.org/obo/owl/GOC#GOC_kd
LH2 complex
light harvesting complex II
PSI associated light-harvesting complex I, LHCIa subcomplex
cellular_component
A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 24 and 21.5 kDa); has a fluorescence maximum between 680 and 690 nm.
PMID:8825475
http://purl.org/obo/owl/PMID#PMID_8825475
PSI associated light-harvesting complex I, LHCIb subcomplex
cellular_component
A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 20 kDa); has a fluorescence maximum of 730 nm.
PMID:8825475
http://purl.org/obo/owl/PMID#PMID_8825475
PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex
cellular_component
A pigment protein complex that forms part of the photosystem II associated light-harvesting complex II; contains two proteins (usually about 28 and 27 kDa), and may contain a third; peripherally located relative to other LHC polypeptides.
PMID:8825475
http://purl.org/obo/owl/PMID#PMID_8825475
PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex
This term was made obsolete because the 'complex' it refers to contains only one gene product.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex
This term was made obsolete because the 'complex' it refers to contains only one gene product.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PSII associated light-harvesting complex II, core complex, LHCIId subcomplex
This term was made obsolete because the 'complex' it refers to contains only one gene product.
cellular_component
OBSOLETE (was not defined before being made obsolete).
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
phycobilisome
cellular_component
Wikipedia:Phycobilisome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Phycobilisome
Any of the granules, approximately 32 nm x 48 nm and consisting of highly aggregated phycobiliproteins, that are attached in arrays to the external face of a thylakoid membrane in algae of the phyla Cyanophyta and Rhodophyta, where they function as light-harvesting devices in photosynthesis. Excitation energy in the phycobilisome flows in the sequence: phycoerythrin, phycocyanin, allophycocyanin before passing to the antenna chlorophyll of photosystem II.
PMID:11734882
http://purl.org/obo/owl/PMID#PMID_11734882
Wikipedia:Phycobilisome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Phycobilisome
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
chloroplast photosystem I
cellular_component
Photosystem located in the chloroplast that functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. An example of this is found in Arabidopsis thaliana.
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
plasma membrane-derived photosystem I
cellular_component
A protein complex located in the plasma membrane-derived thylakoid. The photosystem functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. Examples of this complex are found in bacterial species.
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
plasma membrane photosystem I
chloroplast photosystem II
cellular_component
An integral chloroplast membrane complex containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
plasma membrane-derived thylakoid photosystem II
cellular_component
plasma membrane photosystem II
A protein complex, located in the membrane-derived thylakoid, containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone.
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
glycocalyx
cellular_component
A viscous, carbohydrate rich layer at the outermost periphery of a cell.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
ISBN:0815316208
http://purl.org/obo/owl/ISBN#ISBN_0815316208
Wikipedia:Glycocalyx
http://purl.org/obo/owl/Wikipedia#Wikipedia_Glycocalyx
slime layer
cellular_component
A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell. Specifically this consists mostly of exopolysaccharides, glycoproteins, and glycolipids.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
Wikipedia:Slime_layer
http://purl.org/obo/owl/Wikipedia#Wikipedia_Slime_layer
Wikipedia:Slime_layer
http://purl.org/obo/owl/Wikipedia#Wikipedia_Slime_layer
S-layer
cellular_component
Wikipedia:S-layer
http://purl.org/obo/owl/Wikipedia#Wikipedia_S-layer
A crystalline protein layer surrounding some bacteria.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
ISBN:0815108893
http://purl.org/obo/owl/ISBN#ISBN_0815108893
membrane coat
cellular_component
Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
clathrin coat
GO:0016190
cellular_component
NIF_Subcellular:sao879919129
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao879919129
clathrin cage
Wikipedia:Clathrin
http://purl.org/obo/owl/Wikipedia#Wikipedia_Clathrin
A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:11252894
http://purl.org/obo/owl/PMID#PMID_11252894
PMID:9531549
http://purl.org/obo/owl/PMID#PMID_9531549
AP-type membrane coat adaptor complex
cellular_component
Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa).
PMID:10611976
http://purl.org/obo/owl/PMID#PMID_10611976
PMID:15473838
http://purl.org/obo/owl/PMID#PMID_15473838
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
clathrin adaptor
vesicle coat
cellular_component
A membrane coat found on a coated vesicle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
NIF_Subcellular:sao1177708494
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1177708494
AP-1 adaptor complex
cellular_component
HA1
HA1 clathrin adaptor
A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:21097499
http://purl.org/obo/owl/PMID#PMID_21097499
PMID:10611976
http://purl.org/obo/owl/PMID#PMID_10611976
AP-2 adaptor complex
cellular_component
A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:10611976
http://purl.org/obo/owl/PMID#PMID_10611976
PMID:21097499
http://purl.org/obo/owl/PMID#PMID_21097499
HA2 clathrin adaptor
HA2
AP-3 adaptor complex
cellular_component
A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B).
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:10611976
http://purl.org/obo/owl/PMID#PMID_10611976
PMID:21097499
http://purl.org/obo/owl/PMID#PMID_21097499
AP-4 adaptor complex
cellular_component
An AP-type membrane coat adaptor complex that consists of beta4, epsilon, mu4 and sigma4 subunits and is found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo.
PMID:10611976
http://purl.org/obo/owl/PMID#PMID_10611976
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
clathrin vesicle coat
cellular_component
A clathrin coat found on a vesicle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
COPI vesicle coat
GO:0017167
cellular_component
coatomer
One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:11252894
http://purl.org/obo/owl/PMID#PMID_11252894
COPII vesicle coat
cellular_component
One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state.
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
PMID:11252894
http://purl.org/obo/owl/PMID#PMID_11252894
GOC:ascb_2009
http://purl.org/obo/owl/GOC#GOC_ascb_2009
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
clathrin coat of endocytic vesicle
cellular_component
clathrin coat of endocytotic vesicle
A clathrin coat found on an endocytic vesicle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
clathrin coat of synaptic vesicle
cellular_component
A clathrin coat found on a synaptic vesicle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
clathrin coat of trans-Golgi network vesicle
cellular_component
A clathrin coat found on a vesicle of the trans-Golgi network.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
clathrin coat of TGN vesicle
clathrin adaptor complex
cellular_component
A membrane coat adaptor complex that links clathrin to a membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
clathrin coat of coated pit
cellular_component
The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
transport vesicle
Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'.
cellular_component
secretory vesicle
Golgi to vacuole transport vesicle
Golgi-vacuole transport vesicle
constitutive secretory pathway transport vesicle
Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, or to destinations within or outside the cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
NIF_Subcellular:sao885490876
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao885490876
ER to Golgi transport vesicle
GO:0030138
cellular_component
COPII vesicle
endoplasmic reticulum to Golgi transport vesicle
endoplasmic reticulum-Golgi transport vesicle
ER to Golgi constitutive secretory pathway transport vesicle
ER-Golgi transport vesicle
COPII-coated vesicle
A vesicle that mediates transport from the endoplasmic reticulum to the Golgi complex; bears a coat formed of the COPII coat complex proteins; such vesicles found associated with endoplasmic reticulum (ER) membranes at steady state, and are involved in ER to Golgi (anterograde) vesicle transport.
GOC:ascb_2009
http://purl.org/obo/owl/GOC#GOC_ascb_2009
PMID:11252894
http://purl.org/obo/owl/PMID#PMID_11252894
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
coated vesicle
cellular_component
GO:0005909
Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
NIF_Subcellular:sao1985096626
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1985096626
clathrin-coated vesicle
cellular_component
A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
PMID:11252894
http://purl.org/obo/owl/PMID#PMID_11252894
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
NIF_Subcellular:sao148845161
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao148845161
COPI-coated vesicle
cellular_component
coatomer
A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:11252894
http://purl.org/obo/owl/PMID#PMID_11252894
endocytic vesicle
cellular_component
NIF_Subcellular:sao1362520468
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1362520468
endocytotic transport vesicle
endocytotic vesicle
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
PMID:19696797
http://purl.org/obo/owl/PMID#PMID_19696797
trans-Golgi network transport vesicle
cellular_component
A vesicle that mediates transport between the trans-Golgi network and other parts of the cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
trans-Golgi network constitutive secretory pathway transport vesicle
TGN transport vesicle
secretory granule
Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'.
cellular_component
A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
ISBN:0198596732
http://purl.org/obo/owl/ISBN#ISBN_0198596732
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
secretory vesicle
Golgi to ER transport vesicle
cellular_component
Golgi-ER transport vesicle
A vesicle that mediates transport from the Golgi to the endoplasmic reticulum.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Golgi-endoplasmic reticulum transport vesicle
Golgi to ER constitutive secretory pathway transport vesicle
Golgi to endoplasmic reticulum transport vesicle
inter-Golgi transport vesicle
GO:0005807
cellular_component
A vesicle that mediates transport of cargo within the Golgi complex (for example, between cisternae of the Golgi stack).
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
inter-Golgi transport constitutive secretory pathway transport vesicle
NIF_Subcellular:sao1382918459
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1382918459
integral to Golgi membrane
cellular_component
Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the Golgi complex membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
Golgi integral membrane protein
filopodium
cellular_component
GO:0030028
Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
NIF_Subcellular:sao-1046371754
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao-1046371754
Wikipedia:Filopodia
http://purl.org/obo/owl/Wikipedia#Wikipedia_Filopodia
integral to endoplasmic reticulum membrane
cellular_component
integral to ER membrane
ER integral membrane protein
Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
insulin control element activator complex
cellular_component
Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription.
PMID:7935390
http://purl.org/obo/owl/PMID#PMID_7935390
ICE activator complex
type I protein secretion system complex
cellular_component
A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space.
PMID:9618447
http://purl.org/obo/owl/PMID#PMID_9618447
ABC translocator complex
type III protein secretion system complex
cellular_component
A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase.
PMID:9618447
http://purl.org/obo/owl/PMID#PMID_9618447
T3SS complex
TTSS complex
integral to synaptic vesicle membrane
cellular_component
Penetrating at least one phospholipid bilayer of a synaptic vesicle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
dynein complex
cellular_component
Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
cell wall-bounded periplasmic space
cellular_component
cell wall bounded periplasmic space
cell wall-enclosed periplasmic space
The region between the plasma membrane and the cell wall, as found in organisms such as yeast and Gram positive bacteria. The region is thinner than the equivalent in Gram negative bacteria.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
outer membrane-bounded periplasmic space
cellular_component
outer membrane bounded periplasmic space
Wikipedia:Periplasmic_space
http://purl.org/obo/owl/Wikipedia#Wikipedia_Periplasmic_space
outer membrane-enclosed periplasmic space
The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
protein phosphatase 4 complex
cellular_component
The complex formed by the catalytic subunit of protein phosphatase 4 plus a regulatory subunit.
PMID:10026142
http://purl.org/obo/owl/PMID#PMID_10026142
external encapsulating structure
cellular_component
A structure that lies outside the plasma membrane and surrounds the entire cell.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
cell envelope
cellular_component
Wikipedia:Cell_envelope
http://purl.org/obo/owl/Wikipedia#Wikipedia_Cell_envelope
An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
GOC:ds
http://purl.org/obo/owl/GOC#GOC_ds
URL:http://pathmicro.med.sc.edu/fox/cell_envelope.htm
http://pathmicro.med.sc.edu/fox/cell_envelope.htm
junctional membrane complex
cellular_component
triad junction
Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules).
PMID:11535622
http://purl.org/obo/owl/PMID#PMID_11535622
T-tubule
cellular_component
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
GOC:mtg_muscle
http://purl.org/obo/owl/GOC#GOC_mtg_muscle
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
transverse tubule
Wikipedia:T-tubule
http://purl.org/obo/owl/Wikipedia#Wikipedia_T-tubule
triad
ferredoxin:thioredoxin reductase complex
Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'ferredoxin:thioredoxin reductase activity ; GO:0030385'.
cellular_component
A protein complex that possesses ferredoxin:thioredoxin reductase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
axon
cellular_component
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
GOC:nln
http://purl.org/obo/owl/GOC#GOC_nln
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
Wikipedia:Axon
http://purl.org/obo/owl/Wikipedia#Wikipedia_Axon
NIF_Subcellular:sao1770195789
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1770195789
dendrite
cellular_component
NIF_Subcellular:sao1211023249
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1211023249
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:nln
http://purl.org/obo/owl/GOC#GOC_nln
GOC:dos
http://purl.org/obo/owl/GOC#GOC_dos
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
Wikipedia:Dendrite
http://purl.org/obo/owl/Wikipedia#Wikipedia_Dendrite
growth cone
cellular_component
The migrating motile tip of a growing nerve cell axon or dendrite.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
Wikipedia:Growth_cone
http://purl.org/obo/owl/Wikipedia#Wikipedia_Growth_cone
site of polarized growth
cellular_component
GO:0000134
GO:0030483
Any part of a cell where non-isotropic growth takes place.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cell septum
cellular_component
septum
A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells.
ISBN:0471940526
http://purl.org/obo/owl/ISBN#ISBN_0471940526
GOC:clt
http://purl.org/obo/owl/GOC#GOC_clt
cross wall
host cell cytoplasm
cellular_component
The cytoplasm of a host cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
yeast-form cell wall
See also the Fungal Anatomy Ontology term 'vegetative cell ; FAO:0000032'.
cellular_component
The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form.
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
hyphal cell wall
See also the Fungal Anatomy Ontology term 'hypha ; FAO:0001001'.
cellular_component
The cell wall surrounding a fungal hypha.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
actin cap
GO:0000143
cellular_component
Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:10652251
http://purl.org/obo/owl/ISBN#ISBN_10652251
actin cortical patch
GO:0005857
cellular_component
A discrete actin-containing structure found at the plasma membrane in cells, at sites of endocytosis; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae.
ISBN:0879693649
http://purl.org/obo/owl/ISBN#ISBN_0879693649
PMID:16959963
http://purl.org/obo/owl/PMID#PMID_16959963
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
ISBN:0879693568
http://purl.org/obo/owl/ISBN#ISBN_0879693568
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
actin patch
muscle fiber
This term was made obsolete because a muscle fiber is a cell type rather than a cell component. To update annotations, consider the external ontology term 'muscle cell ; CL:0000187'.
cellular_component
muscle fibre
OBSOLETE. The contractile fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
smooth muscle contractile fiber
cellular_component
smooth muscle fibre
smooth muscle fiber
The contractile fiber of smooth muscle cells.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
smooth muscle dense body
cellular_component
Electron-dense region associated with a smooth muscle contractile fiber.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
midbody
cellular_component
Wikipedia:Midbody_(cell_biology)
http://purl.org/obo/owl/Wikipedia#Wikipedia_Midbody_(cell_biology)
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
granulocyte macrophage colony-stimulating factor receptor complex
cellular_component
granulocyte macrophage colony stimulating factor receptor complex
The heterodimeric receptor for granulocyte macrophage colony-stimulating factor.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ribonucleoprotein complex
cellular_component
protein-RNA complex
RNA-protein complex
ribonucleoprotein
RNP
Wikipedia:Ribonucleoprotein
http://purl.org/obo/owl/Wikipedia#Wikipedia_Ribonucleoprotein
A macromolecular complex containing both protein and RNA molecules.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
heterogeneous nuclear ribonucleoprotein complex
cellular_component
Particulate complex of heterogeneous nuclear RNA (hnRNA; a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis; it is the form of RNA synthesized in eukaryotes by RNA polymerase II, that which is translated into protein) with protein, which is cell-specific and heterogeneous. The protein component may play a role in the processing of the hnRNA to mRNA.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
Wikipedia:Heterogeneous_ribonucleoprotein_particle
http://purl.org/obo/owl/Wikipedia#Wikipedia_Heterogeneous_ribonucleoprotein_particle
hnRNP
heterogeneous nuclear ribonucleoprotein
small cytoplasmic ribonucleoprotein complex
cellular_component
scRNP
small cytoplasmic ribonucleoprotein
A complex composed of RNA of the small cytoplasmic RNA (scRNA) class and protein, found in the cytoplasm.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
small nuclear ribonucleoprotein complex
cellular_component
Wikipedia:SnRNP
http://purl.org/obo/owl/Wikipedia#Wikipedia_SnRNP
snRNP
small nuclear ribonucleoprotein
A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
transport vesicle membrane
cellular_component
constitutive secretory pathway transport vesicle membrane
The lipid bilayer surrounding a transport vesicle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
secretory vesicle membrane
cytoplasmic vesicle membrane
cellular_component
The lipid bilayer surrounding a cytoplasmic vesicle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Golgi-associated vesicle membrane
cellular_component
The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Golgi vesicle membrane
chitosome membrane
cellular_component
The lipid bilayer surrounding a chitosome.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
coated vesicle membrane
cellular_component
The lipid bilayer surrounding a coated vesicle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
COPI coated vesicle membrane
cellular_component
The lipid bilayer surrounding a COPI-coated vesicle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
clathrin coated vesicle membrane
cellular_component
The lipid bilayer surrounding a clathrin-coated vesicle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
endocytic vesicle membrane
cellular_component
The lipid bilayer surrounding an endocytic vesicle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
secretory granule membrane
cellular_component
The lipid bilayer surrounding a secretory granule.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
secretory vesicle membrane
merozoite dense granule membrane
cellular_component
The lipid bilayer surrounding a dense granule of the type found in apicomplexan parasites.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
clathrin-coated endocytic vesicle membrane
cellular_component
The lipid bilayer surrounding a clathrin-coated endocytic vesicle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
phagocytic vesicle membrane
cellular_component
phagosome membrane
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
The lipid bilayer surrounding a phagocytic vesicle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
clathrin-coated phagocytic vesicle membrane
cellular_component
The lipid bilayer surrounding a clathrin-coated phagocytic vesicle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
synaptic vesicle membrane
cellular_component
The lipid bilayer surrounding a synaptic vesicle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
axolemma
cellular_component
axonal membrane
GOC:vk
http://purl.org/obo/owl/GOC#GOC_vk
The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness.
URL:http://www.medik.sk/clanky/bio_jun.htm
http://www.medik.sk/clanky/bio_jun.htm
ISBN:0124325653
http://purl.org/obo/owl/ISBN#ISBN_0124325653
Wikipedia:Axolemma
http://purl.org/obo/owl/Wikipedia#Wikipedia_Axolemma
NIF_Subcellular:sao250772229
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao250772229
ribonuclease P complex
Note that chloroplasts possess a complex that is called 'RNase P' because it catalyzes pre-tRNA cleavage, but the chloroplast complex appears not to contain RNA.
cellular_component
A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:12045094
http://purl.org/obo/owl/PMID#PMID_12045094
RNase P complex
mitochondrial ribonuclease P complex
cellular_component
mitochondrial RNase P complex
A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species, but the complex often contains a single RNA molecule and a single protein molecule.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:12045094
http://purl.org/obo/owl/PMID#PMID_12045094
cyanelle ribonuclease P complex
cellular_component
cyanelle RNase P complex
A ribonuclease P complex located in the cyanelle, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The best characterized cyanelle ribonuclease P complex, from the alga Cyanophora paradoxa, contains a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules.
PMID:12045094
http://purl.org/obo/owl/PMID#PMID_12045094
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
dimeric ribonuclease P complex
cellular_component
dimeric RNase P complex
A ribonuclease P complex that contains a single RNA molecule that is necessary and usually sufficient for catalysis, and a single protein molecule. Examples of this complex are found in Bacterial species.
PMID:12045094
http://purl.org/obo/owl/PMID#PMID_12045094
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
multimeric ribonuclease P complex
cellular_component
multimeric RNase P complex
A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules. Examples of this complex are found in Archaeal species.
PMID:12045094
http://purl.org/obo/owl/PMID#PMID_12045094
PMID:11142368
http://purl.org/obo/owl/PMID#PMID_11142368
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
preribosome
cellular_component
Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis.
PMID:10567516
http://purl.org/obo/owl/PMID#PMID_10567516
nucleolar preribosome
cellular_component
Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed in the nucleolus during ribosome biogenesis.
PMID:10567516
http://purl.org/obo/owl/PMID#PMID_10567516
90S preribosome
cellular_component
A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
PMID:12150911
http://purl.org/obo/owl/PMID#PMID_12150911
PMID:12957375
http://purl.org/obo/owl/PMID#PMID_12957375
PMID:15120992
http://purl.org/obo/owl/PMID#PMID_15120992
preribosome, large subunit precursor
Note that this complex is 66S in Saccharomyces.
cellular_component
A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.
PMID:10567516
http://purl.org/obo/owl/PMID#PMID_10567516
66S preribosome
preribosome, small subunit precursor
Note that this complex is 43S in Saccharomyces.
cellular_component
43S preribosome
A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.
PMID:10567516
http://purl.org/obo/owl/PMID#PMID_10567516
Noc complex
Note that the definition uses Saccharomyces gene product names because this complex has only been described in Saccharomyces cerevisiae and no other names have yet arisen; the term nevertheless can be used for analogous complexes in other eukaryotes, and the definition can be changed if better wording is found.
cellular_component
Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis.
PMID:12446671
http://purl.org/obo/owl/PMID#PMID_12446671
Noc1p-Noc2p complex
Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
cellular_component
A heterodimer associated with 90S and 66S preribosomes in the nucleolus; involved in ribosomal large subunit biogenesis.
PMID:12446671
http://purl.org/obo/owl/PMID#PMID_12446671
Noc2p-Noc3p complex
Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
cellular_component
A heterodimer associated with 66S preribosomes; also found throughout the nucleoplasm; involved in ribosomal large subunit biogenesis.
PMID:12446671
http://purl.org/obo/owl/PMID#PMID_12446671
Noc4p-Nop14p complex
Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
cellular_component
A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis.
PMID:12446671
http://purl.org/obo/owl/PMID#PMID_12446671
Nop7 complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:jh
http://purl.org/obo/owl/GOC#GOC_jh
Nop7 subcomplex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:18448671
http://purl.org/obo/owl/PMID#PMID_18448671
GOC:jh
http://purl.org/obo/owl/GOC#GOC_jh
bacterial-type flagellum basal body, rod
cellular_component
The central portion of the flagellar basal body, which spans the periplasm and threads through the rings. Examples of this component are found in Bacterial species.
PMID:12624192
http://purl.org/obo/owl/PMID#PMID_12624192
PMID:10572114
http://purl.org/obo/owl/PMID#PMID_10572114
PMID:11133968
http://purl.org/obo/owl/PMID#PMID_11133968
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
flagellar basal body, rod
flagellin-based flagellum basal body, rod
glycine reductase complex
Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glycine reductase activity ; GO:0030699'.
cellular_component
Complex that possesses glycine reductase activity; usually comprises three subunits, of which two are selenoproteins; the subunits are typically designated selenoprotein A, selenoprotein B and protein C.
PMID:2018775
http://purl.org/obo/owl/PMID#PMID_2018775
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
autosome
Note that this term is mainly relevant in organisms that have both sex chromosomes and non-sex-determining chromosomes in an individual organism.
cellular_component
Wikipedia:Autosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Autosome
Any chromosome other than a sex chromosome.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cortical cytoskeleton
cellular_component
The portion of the cytoskeleton that lies just beneath the plasma membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cortical actin cytoskeleton
cellular_component
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
rough endoplasmic reticulum membrane
cellular_component
The lipid bilayer surrounding the rough endoplasmic reticulum.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
RER membrane
rough ER membrane
smooth endoplasmic reticulum membrane
cellular_component
NIF_Subcellular:sao1596955044
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1596955044
The lipid bilayer surrounding the smooth endoplasmic reticulum.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
smooth ER membrane
SER membrane
RENT complex
cellular_component
A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit.
PMID:12196389
http://purl.org/obo/owl/PMID#PMID_12196389
Mre11 complex
cellular_component
RMX complex
Rad50-Rad32-Nbs1 complex
Rad50 complex
RAD50-MRE11-NBN complex
CORUM:2767
http://purl.org/obo/owl/CORUM#CORUM_2767
MRN complex
Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
PMID:17674145
http://purl.org/obo/owl/PMID#PMID_17674145
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:11988766
http://purl.org/obo/owl/PMID#PMID_11988766
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
MRX complex
nucleolar chromatin
cellular_component
The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
rDNA protrusion
Note that this component is characterized in Schizosaccharomyces, particularly with respect to the DAPI staining pattern.
cellular_component
Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining.
PMID:1629244
http://purl.org/obo/owl/PMID#PMID_1629244
ribosomal DNA protrusion
interleukin-20 receptor complex
cellular_component
A protein complex that binds interleukin-20; comprises an alpha and a beta subunit.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
IL-20 receptor complex
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
beta-catenin destruction complex
cellular_component
A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
PMID:14600025
http://purl.org/obo/owl/PMID#PMID_14600025
beta-catenin degradation complex
RNA polymerase complex
cellular_component
Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
multisubunit RNA polymerase
VCB complex
cellular_component
VHL complex
von Hippel-Lindau tumor suppressor complex
pVHL-elongin C-elongin B complex
A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1.
PMID:11865071
http://purl.org/obo/owl/PMID#PMID_11865071
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mitotic cohesin complex
cellular_component
A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex.
PMID:12750522
http://purl.org/obo/owl/PMID#PMID_12750522
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
meiotic cohesin complex
cellular_component
A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex.
PMID:12750522
http://purl.org/obo/owl/PMID#PMID_12750522
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
replisome
cellular_component
Wikipedia:Replisome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Replisome
DNA synthesome complex
CORUM:1001
http://purl.org/obo/owl/CORUM#CORUM_1001
RC complex
PMID:12006500
http://purl.org/obo/owl/PMID#PMID_12006500
CORUM:309
http://purl.org/obo/owl/CORUM#CORUM_309
replication-competent complex
CORUM:309
http://purl.org/obo/owl/CORUM#CORUM_309
PMID:12006500
http://purl.org/obo/owl/PMID#PMID_12006500
A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
apolipoprotein B mRNA editing enzyme complex
cellular_component
APOBEC
Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP).
PMID:10781591
http://purl.org/obo/owl/PMID#PMID_10781591
apoB mRNA editing enzyme complex
checkpoint clamp complex
Note that the following subunit names have been used: human RAD9/RAD1/HUS1; S. pombe Rad9/Rad1/Hus1; S. cerevisiae Ddc1p/Rad17p/Mec3p.
cellular_component
Rad9-Hus1-Rad1 (9-1-1) clamp complex
CCC
Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage.
PMID:12531008
http://purl.org/obo/owl/PMID#PMID_12531008
HOPS complex
cellular_component
A multimeric protein complex that associates with the vacuolar membrane and is involved in homotypic vacuole fusion and vacuole protein sorting. For example, the Saccharomyces complex contains Vps41p, Vam6p, Pep5p, Vps16p, Pep3p, and Vps33p.
PMID:10944212
http://purl.org/obo/owl/PMID#PMID_10944212
retromer complex
cellular_component
A conserved multimeric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. For example, the budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p.
PMID:9700157
http://purl.org/obo/owl/PMID#PMID_9700157
retromer complex, outer shell
cellular_component
One of two subcomplexes that combine to form the retromer, believed to be peripherally associated with the membrane. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer.
PMID:9700157
http://purl.org/obo/owl/PMID#PMID_9700157
retromer complex, inner shell
cellular_component
One of two subcomplexes that combine to form the retromer, believed to be closely associated with the membrane. In budding yeast the complex comprises Vps35p, Vps29p, and Vps26p.
PMID:9700157
http://purl.org/obo/owl/PMID#PMID_9700157
MBF transcription complex
cellular_component
A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi4p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:15838511
http://purl.org/obo/owl/PMID#PMID_15838511
PMID:11206552
http://purl.org/obo/owl/PMID#PMID_11206552
PMID:9343385
http://purl.org/obo/owl/PMID#PMID_9343385
PMID:18160399
http://purl.org/obo/owl/PMID#PMID_18160399
MBF
DSC1 transcription factor complex
Mlu1-box binding factor
STAGA complex
See also the cellular component term 'SAGA complex ; GO:0000124'.
cellular_component
SPT3-TAF9-GCN5 acetylase complex
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
PMID:18838386
http://purl.org/obo/owl/PMID#PMID_18838386
STAGA coactivator complex
A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs.
PMID:11564863
http://purl.org/obo/owl/PMID#PMID_11564863
Smc5-Smc6 complex
cellular_component
A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans.
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
PMID:14701739
http://purl.org/obo/owl/PMID#PMID_14701739
ADPG pyrophosphorylase complex
cellular_component
Complex that possesses ADPG pyrophosphorylase activity. In all organisms where it has been found, the complex is a tetramer. In bacteria, it is a homotetramer. In plants, the complex is a heterotetramer composed small and large subunits.
PMID:9680965
http://purl.org/obo/owl/PMID#PMID_9680965
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
homotetrameric ADPG pyrophosphorylase complex
cellular_component
A protein complex composed of four identical subunits that possesses ADPG pyrophosphorylase activity. Examples of this component are found in Bacterial species.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
heterotetrameric ADPG pyrophosphorylase complex
cellular_component
A protein complex composed of four different subunits that possesses ADPG pyrophosphorylase activity. An example of this process is found in Mus musculus.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
amyloplast ADPG pyrophosphorylase complex
cellular_component
An ADPG pyrophosphorylase complex found in the amyloplast.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
chloroplast ADPG pyrophosphorylase complex
cellular_component
An ADPG pyrophosphorylase complex found in the chloroplast.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
anchoring collagen
cellular_component
Any collagen polymer which links one collagen assembly, such as a collagen fibril or sheet, to other structures.
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
linking collagen
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
connecting collagen
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
sheet-forming collagen
cellular_component
network-forming collagen
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
Any collagen polymer in which collagen triple helices associate to form sheet-like networks.
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
transmembrane collagen
cellular_component
MACIT
ISBN:0198599587
http://purl.org/obo/owl/ISBN#ISBN_0198599587
Any collagen polymer that passes through a lipid bilayer membrane.
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
collagen type XVII
cellular_component
A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices associate with hemidesmosomes and the basal lamina.
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
collagen type XVIII
cellular_component
A collagen homotrimer of alpha1(XVIII) chains.
ISBN:0721639976
http://purl.org/obo/owl/ISBN#ISBN_0721639976
glutamyl-tRNA(Gln) amidotransferase complex
Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity ; GO:0050567'.
cellular_component
A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
AdT
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
GatFAB
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
GatCAB
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
RITS complex
cellular_component
A protein complex required for heterochromatin assembly; contains an Argonaute homolog, a chromodomain protein, and at least one additional protein; named for RNA-induced initiation of transcriptional gene silencing.
PMID:14704433
http://purl.org/obo/owl/PMID#PMID_14704433
NADH dehydrogenase complex
Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (quinone) activity ; GO:0050136'.
GO:0045280
GO:0031678
cellular_component
GO:0031677
GO:0031675
GO:0030966
GO:0030025
An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
NADH:plastoquinone reductase complex
plastid NADH dehydrogenase complex (plastoquinone)
Wikipedia:NADH_dehydrogenase
http://purl.org/obo/owl/Wikipedia#Wikipedia_NADH_dehydrogenase
Complex I
NADH dehydrogenase complex (quinone)
NADH dehydrogenase complex (plastoquinone)
NADH dehydrogenase complex (ubiquinone)
cortical microtubule cytoskeleton
cellular_component
The portion of the microtubule cytoskeleton that lies just beneath the plasma membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
high molecular weight kininogen receptor complex
cellular_component
A protein complex that acts as a receptor for high molecular weight kininogens. In humans, this receptor includes the CK1 and uPAR proteins.
PMID:11290596
http://purl.org/obo/owl/PMID#PMID_11290596
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intraflagellar transport particle
cellular_component
A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
PMID:14570576
http://purl.org/obo/owl/PMID#PMID_14570576
IFT complex
intraflagellar transport complex
intraflagellar transport particle A
cellular_component
IFT A complex
intraflagellar transport complex A
The smaller subcomplex of the intraflagellar transport particle; characterized complexes have molecular weights of 710-760 kDa.
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
PMID:14570576
http://purl.org/obo/owl/PMID#PMID_14570576
intraflagellar transport particle B
cellular_component
The larger subcomplex of the intraflagellar transport particle; characterized complexes have molecular weights around 550 kDa.
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
PMID:14570576
http://purl.org/obo/owl/PMID#PMID_14570576
intraflagellar transport complex B
IFT B complex
axonemal heterotrimeric kinesin-II complex
cellular_component
A kinesin complex found in eukaryotic axonemes that contains two distinct plus end-directed kinesin motor proteins and at least one accessory subunit, and that functions in the anterograde transport of molecules (cargo) from the basal body to the distal tip of the axoneme.
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
PMID:14570576
http://purl.org/obo/owl/PMID#PMID_14570576
linear element
cellular_component
A proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase. Linear elements have a structure related to but not equivalent to the synaptonemal complex.
GOC:jb
http://purl.org/obo/owl/GOC#GOC_jb
actin rod
cellular_component
A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and associated proteins. Found in the germinating spores of Dictyostelium discoideum.
GOC:kp
http://purl.org/obo/owl/GOC#GOC_kp
actin tubule
cellular_component
A cellular structure, approximately 13 nm in diameter, consisting of three actin filaments bundled together.
GOC:kp
http://purl.org/obo/owl/GOC#GOC_kp
potassium ion-transporting ATPase complex
cellular_component
Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex.
TIGR_TIGRFAMS:TIGR01497
http://purl.org/obo/owl/TIGR_TIGRFAMS#TIGR_TIGRFAMS_TIGR01497
PMID:10608856
http://purl.org/obo/owl/PMID#PMID_10608856
PMID:9858692
http://purl.org/obo/owl/PMID#PMID_9858692
Kdp system complex
plastid ADPG pyrophosphorylase complex
cellular_component
An ADPG pyrophosphorylase complex found in a plastid.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISWI complex
cellular_component
Any chromatin remodeling complex that contains an ATPase subunit of the ISWI family.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:15020051
http://purl.org/obo/owl/PMID#PMID_15020051
Ino80 complex
cellular_component
INO80 chromatin remodeling complex
A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity.
GOC:jh
http://purl.org/obo/owl/GOC#GOC_jh
extracellular matrix
cellular_component
Wikipedia:Extracellular_matrix
http://purl.org/obo/owl/Wikipedia#Wikipedia_Extracellular_matrix
A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants).
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
karyopherin docking complex
cellular_component
A subcomplex of the nuclear pore complex that interacts with karyopherin-cargo complexes; a well-characterized example in Saccharomyces contains Asm4p, Nup53p, and Nup170p.
PMID:11867631
http://purl.org/obo/owl/PMID#PMID_11867631
PMID:9864357
http://purl.org/obo/owl/PMID#PMID_9864357
Asm4p-containing complex
nuclear pore subcomplex
mitochondrial mRNA editing complex
cellular_component
An mRNA editing complex found in the mitochondrion. The best characterized example is that of Trypanosoma brucei, which catalyzes the insertion and deletion of uridylates.
PMID:12139607
http://purl.org/obo/owl/PMID#PMID_12139607
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mitochondrial editosome
plastid mRNA editing complex
cellular_component
plastid editosome
An mRNA editing complex found in a plastid.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
interphase microtubule organizing center
cellular_component
interphase microtubule organising center
interphase MTOC
iMTOC
A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus.
PMID:15068790
http://purl.org/obo/owl/PMID#PMID_15068790
glutamate synthase complex
cellular_component
A complex that possesses glutamate synthase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
glutamate synthase complex (NADH)
cellular_component
A protein complex that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:7047525
http://purl.org/obo/owl/PMID#PMID_7047525
macronucleus
cellular_component
Wikipedia:Macronucleus
http://purl.org/obo/owl/Wikipedia#Wikipedia_Macronucleus
A membrane-bounded organelle of ciliated protozoan cells that contains polyploid copies of a portion of the cell's complete genome. Transcription of genes occurs in macronuclei. Some ciliate species may contain multiple macronuclei per cell.
GOC:ns
http://purl.org/obo/owl/GOC#GOC_ns
micronucleus
cellular_component
A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell.
GOC:ns
http://purl.org/obo/owl/GOC#GOC_ns
Wikipedia:Micronucleus
http://purl.org/obo/owl/Wikipedia#Wikipedia_Micronucleus
dense core granule
cellular_component
dense core vesicle
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted.
PMID:14690495
http://purl.org/obo/owl/PMID#PMID_14690495
nucleocytoplasmic shuttling complex
cellular_component
Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Nup107-160 complex
cellular_component
A subcomplex of the nuclear pore complex (NPC) involved in mRNA export and NPC assembly. Contains conserved nucleoporins and other proteins; for example, the Saccharomyces complex contains Nup84p, Nup85p, Nup120p, Nup145p-C, Seh1p, Sec13p, and Nup133p.
PMID:10747086
http://purl.org/obo/owl/PMID#PMID_10747086
PMID:11823431
http://purl.org/obo/owl/PMID#PMID_11823431
PMID:15226438
http://purl.org/obo/owl/PMID#PMID_15226438
Nup84 complex
Nup107-120 complex
BLOC complex
cellular_component
Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex.
PMID:15102850
http://purl.org/obo/owl/PMID#PMID_15102850
PMID:15261680
http://purl.org/obo/owl/PMID#PMID_15261680
BLOC-1 complex
cellular_component
A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins.
PMID:15102850
http://purl.org/obo/owl/PMID#PMID_15102850
BLOC-2 complex
cellular_component
A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru.
PMID:12548288
http://purl.org/obo/owl/PMID#PMID_12548288
PMID:15031569
http://purl.org/obo/owl/PMID#PMID_15031569
PMID:14718540
http://purl.org/obo/owl/PMID#PMID_14718540
BLOC-3 complex
cellular_component
A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins.
PMID:12756248
http://purl.org/obo/owl/PMID#PMID_12756248
platelet dense granule membrane
cellular_component
The lipid bilayer surrounding the platelet dense granule.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
platelet dense granule lumen
cellular_component
The volume enclosed by the membrane of the platelet dense granule.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
organelle membrane
cellular_component
The lipid bilayer surrounding an organelle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
platelet alpha granule
cellular_component
Wikipedia:Platelet_alpha-granule
http://purl.org/obo/owl/Wikipedia#Wikipedia_Platelet_alpha-granule
A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG).
PMID:8467233
http://purl.org/obo/owl/PMID#PMID_8467233
platelet alpha-granule
platelet alpha granule membrane
cellular_component
The lipid bilayer surrounding the platelet alpha granule.
PMID:8467233
http://purl.org/obo/owl/PMID#PMID_8467233
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
platelet alpha-granule membrane
platelet alpha granule lumen
cellular_component
The volume enclosed by the membrane of the platelet alpha granule.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:8467233
http://purl.org/obo/owl/PMID#PMID_8467233
platelet alpha-granule lumen
platelet dense tubular network
cellular_component
A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin.
PMID:1322202
http://purl.org/obo/owl/PMID#PMID_1322202
platelet dense tubular network membrane
cellular_component
The lipid bilayer surrounding the platelet dense tubular network.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:1322202
http://purl.org/obo/owl/PMID#PMID_1322202
platelet dense tubular network lumen
cellular_component
The volume enclosed by the membranes of the platelet dense tubular network.
PMID:1322202
http://purl.org/obo/owl/PMID#PMID_1322202
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
medial cortex
cellular_component
medial ring
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning and plays a role in cell cycle regulation.
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:19474789
http://purl.org/obo/owl/PMID#PMID_19474789
PMID:15572668
http://purl.org/obo/owl/PMID#PMID_15572668
septin complex
cellular_component
Any of several heterooligomeric complexes containing multiple septins.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:15385632
http://purl.org/obo/owl/PMID#PMID_15385632
pseudopodium
cellular_component
A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
pseudopod
Wikipedia:Pseudopod
http://purl.org/obo/owl/Wikipedia#Wikipedia_Pseudopod
spore wall
cellular_component
spore coat
The specialized envelope lying outside the cell membrane of a spore.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:pg
http://purl.org/obo/owl/GOC#GOC_pg
contractile vacuolar membrane
cellular_component
contractile vacuole membrane
GOC:pf
http://purl.org/obo/owl/GOC#GOC_pf
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
The lipid bilayer surrounding the contractile vacuole.
GOC:pg
http://purl.org/obo/owl/GOC#GOC_pg
integral to contractile vacuolar membrane
cellular_component
Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the contractile vacuolar membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:pg
http://purl.org/obo/owl/GOC#GOC_pg
integral to vacuolar membrane
cellular_component
Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the vacuolar membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
SNARE complex
cellular_component
A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.
PMID:10872468
http://purl.org/obo/owl/PMID#PMID_10872468
endoplasmic reticulum Sec complex
cellular_component
An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex.
PMID:14617809
http://purl.org/obo/owl/PMID#PMID_14617809
PMID:12158317
http://purl.org/obo/owl/PMID#PMID_12158317
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
Sec62/Sec63 complex
cellular_component
Sec62/63 complex
ER protein translocation subcomplex
A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p.
PMID:12518317
http://purl.org/obo/owl/PMID#PMID_12518317
PMID:14617809
http://purl.org/obo/owl/PMID#PMID_14617809
SCAR complex
cellular_component
WAVE complex
A heterotetrameric complex that includes orthologues of human PIR121, Nap125 and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction.
GOC:pg
http://purl.org/obo/owl/GOC#GOC_pg
PMID:12181570
http://purl.org/obo/owl/PMID#PMID_12181570
endoplasmic reticulum palmitoyltransferase complex
cellular_component
A dimeric complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue.
GOC:jh
http://purl.org/obo/owl/GOC#GOC_jh
RSF complex
cellular_component
A chromatin remodeling complex that mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In humans, the complex is composed of the ATPase hSNF2H and the HBXAP protein (RSF-1).
PMID:12972596
http://purl.org/obo/owl/PMID#PMID_12972596
remodeling and spacing factor complex
intrinsic to membrane
Note that proteins intrinsic to membranes cannot be removed without disrupting the membrane, e.g. by detergent.
cellular_component
Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
anchored to membrane
cellular_component
Tethered to a membrane by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. When used to describe a protein, indicates that none of the peptide sequence is embedded in the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to plasma membrane
cellular_component
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to endoplasmic reticulum membrane
cellular_component
Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to Golgi membrane
cellular_component
Located in the Golgi membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to nuclear inner membrane
cellular_component
Located in the nuclear inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to cell outer membrane
cellular_component
Located in the cell outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
intrinsic to peroxisomal membrane
cellular_component
Located in the peroxisomal membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
extrinsic to external side of plasma membrane
cellular_component
Loosely bound to the surface of the plasma membrane that faces away from the cytoplasm, but not integrated into the hydrophobic region.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to external side of plasma membrane
cellular_component
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side opposite to the side that faces the cytoplasm.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
extrinsic to internal side of plasma membrane
Consider also annotating to 'cell cortex ; GO:0005938'.
cellular_component
Loosely bound to the surface of the plasma membrane that faces the cytoplasm, but not integrated into the hydrophobic region.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to internal side of plasma membrane
cellular_component
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side that faces the cytoplasm.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
extrinsic to external side of plasma membrane, in periplasmic space
GO:0031238
cellular_component
Located in the periplasmic space and loosely bound to the surface of the plasma membrane that faces away from the cytoplasm, but not integrated into the hydrophobic region.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to external side of plasma membrane, in periplasmic space
cellular_component
GO:0031239
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located in the periplasmic space.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
external side of cell outer membrane
cellular_component
The side of the outer membrane that is opposite to the side that faces the periplasm of the cell.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
external side of outer membrane
internal side of cell outer membrane
cellular_component
internal side of outer membrane
The side of the outer membrane that faces the periplasm of the cell.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
extrinsic to external side of cell outer membrane
cellular_component
Loosely bound to the surface of the outer membrane of the cell that faces away from the cytoplasm, but not integrated into the hydrophobic region.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
extrinsic to external side of outer membrane
intrinsic to external side of cell outer membrane
cellular_component
Located in the outer membrane of the cell such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side opposite to the side that faces the periplasm.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to external side of outer membrane
extrinsic to cell outer membrane
cellular_component
Loosely bound to one surface of the outer membrane of the cell, but not integrated into the hydrophobic region.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
extrinsic to internal side of cell outer membrane
cellular_component
Loosely bound to the surface of the outer membrane of the cell that faces the cytoplasm, but not integrated into the hydrophobic region.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
extrinsic to internal side of outer membrane
intrinsic to internal side of cell outer membrane
cellular_component
intrinsic to internal side of outer membrane
Located in the outer membrane of the cell such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side that faces the periplasm.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
protein acetyltransferase complex
cellular_component
A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
anaerobic ribonucleoside-triphosphate reductase complex
cellular_component
An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
PAN complex
cellular_component
poly(A) nuclease complex
A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces.
PMID:9774670
http://purl.org/obo/owl/PMID#PMID_9774670
cell leading edge
cellular_component
The area of a motile cell closest to the direction of movement.
GOC:pg
http://purl.org/obo/owl/GOC#GOC_pg
leading edge of cell
front of cell
cell projection membrane
cellular_component
membrane projection
The portion of the plasma membrane surrounding a cell surface projection.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
membrane extension
trailing edge
cellular_component
The area of a motile cell opposite to the direction of movement.
GOC:pg
http://purl.org/obo/owl/GOC#GOC_pg
back of cell
lateral part of motile cell
cellular_component
The area of a motile cell perpendicular to the direction of movement.
GOC:pg
http://purl.org/obo/owl/GOC#GOC_pg
leading edge membrane
cellular_component
The portion of the plasma membrane surrounding the leading edge of a motile cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
trailing edge membrane
cellular_component
The portion of the plasma membrane surrounding the trailing edge of a motile cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
lamellipodium membrane
cellular_component
The portion of the plasma membrane surrounding a lamellipodium.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
uropod membrane
cellular_component
The portion of the plasma membrane surrounding a uropod.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
uropodium membrane
pseudopodium membrane
cellular_component
The portion of the plasma membrane surrounding a pseudopodium.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
DNA replication preinitiation complex
cellular_component
A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present.
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:12694535
http://purl.org/obo/owl/PMID#PMID_12694535
PMID:15194812
http://purl.org/obo/owl/PMID#PMID_15194812
pre-IC
Ndc80 complex
cellular_component
A protein complex conserved among eukaryotes that forms part of the kinetochore and plays an essential role in forming stable kinetochore-microtubule attachments. The complex contains proteins known in several species, including budding and fission yeasts, as Ndc80p, Nuf2p, Spc24p, and Spc25p. In vertebrates it is part of the outer plate of the kinetochore.
PMID:15509863
http://purl.org/obo/owl/PMID#PMID_15509863
PMID:15661517
http://purl.org/obo/owl/PMID#PMID_15661517
Nuf2-Ndc80 complex
death-inducing signaling complex
cellular_component
death receptor-induced signaling complex
death-inducing signalling complex
death receptor-induced signalling complex
Wikipedia:Death-inducing_signaling_complex
http://purl.org/obo/owl/Wikipedia#Wikipedia_Death-inducing_signaling_complex
DISC protein complex
A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor.
PMID:12628743
http://purl.org/obo/owl/PMID#PMID_12628743
PMID:12655293
http://purl.org/obo/owl/PMID#PMID_12655293
GOC:mtg_apoptosis
http://purl.org/obo/owl/GOC#GOC_mtg_apoptosis
PMID:8521815
http://purl.org/obo/owl/PMID#PMID_8521815
DISC
CD95 death-inducing signaling complex
cellular_component
Fas death-inducing signaling complex
A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor.
PMID:12628743
http://purl.org/obo/owl/PMID#PMID_12628743
PMID:12655293
http://purl.org/obo/owl/PMID#PMID_12655293
CD95 DISC
CD95 death-inducing signalling complex
TRAIL death-inducing signaling complex
cellular_component
A protein complex formed upon binding of TRAIL to its ligand. The complex includes FADD/Mort1 and procaspase-8 addition to the ligand-bound receptor.
PMID:12628743
http://purl.org/obo/owl/PMID#PMID_12628743
PMID:12655293
http://purl.org/obo/owl/PMID#PMID_12655293
TRAIL death-inducing signalling complex
TRAIL DISC
replication fork protection complex
cellular_component
A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling.
PMID:15367656
http://purl.org/obo/owl/PMID#PMID_15367656
Swi1-Swi3 complex
TIMELESS-TIPIN complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
replisome progression complex
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
intrinsic to organelle membrane
cellular_component
Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
integral to organelle membrane
cellular_component
Penetrating at least one phospholipid bilayer of an organelle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to endosome membrane
cellular_component
Located in the endosome membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
integral to endosome membrane
cellular_component
Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the endosome membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to mitochondrial inner membrane
cellular_component
Located in the mitochondrial inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
integral to mitochondrial inner membrane
cellular_component
Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the mitochondrial inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to mitochondrial outer membrane
cellular_component
Located in the mitochondrial outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
integral to mitochondrial outer membrane
cellular_component
Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the mitochondrial outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to nuclear outer membrane
cellular_component
Located in the nuclear outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
integral to nuclear outer membrane
cellular_component
Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the nuclear outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to vacuolar membrane
cellular_component
Located in the vacuolar membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to contractile vacuolar membrane
cellular_component
Located in the contractile vacuolar membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
extrinsic to organelle membrane
cellular_component
Loosely bound to one surface of an organelle membrane, but not integrated into the hydrophobic region.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
extrinsic to endosome membrane
cellular_component
Loosely bound to one surface of the endosome membrane, but not integrated into the hydrophobic region.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
extrinsic to mitochondrial inner membrane
cellular_component
Loosely bound to one surface of the mitochondrial inner membrane, but not integrated into the hydrophobic region.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
extrinsic to mitochondrial outer membrane
cellular_component
Loosely bound to one surface of the mitochondrial outer membrane, but not integrated into the hydrophobic region.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
extrinsic to nuclear outer membrane
cellular_component
Loosely bound to one surface of the nuclear outer membrane, but not integrated into the hydrophobic region.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
tripartite ATP-independent periplasmic transporter complex
cellular_component
A complex consisting of two membrane proteins and one extracytoplasmic solute receptor. Such transporters transport a variety of substrates without direct ATP power, instead using energy from ion gradients.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
TRAP-T transporter complex
TRAP transporter complex
RNAi effector complex
cellular_component
Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins.
PMID:14704433
http://purl.org/obo/owl/PMID#PMID_14704433
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to plastid membrane
cellular_component
Located in a plastid membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
integral to plastid membrane
cellular_component
Penetrating at least one phospholipid bilayer of a plastid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to plastid inner membrane
cellular_component
Located in a plastid inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
integral to plastid inner membrane
cellular_component
Penetrating at least one phospholipid bilayer of a plastid inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to plastid outer membrane
cellular_component
Located in a plastid outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
integral to plastid outer membrane
cellular_component
Penetrating at least one phospholipid bilayer of a plastid outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to chloroplast inner membrane
cellular_component
Located in the chloroplast inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
integral to chloroplast inner membrane
cellular_component
Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the chloroplast inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to chloroplast outer membrane
cellular_component
Located in the chloroplast outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
integral to chloroplast outer membrane
cellular_component
Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the chloroplast outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to thylakoid membrane
cellular_component
Located in a thylakoid membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
integral to thylakoid membrane
cellular_component
Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
anchored to external side of plasma membrane
cellular_component
Tethered to the plasma membrane by a covalently attached anchor, such as a lipid group, that is embedded in the membrane, with the bulk of the gene product located on the side opposite to the side that faces the cytoplasm. When used to describe a protein, indicates that the peptide sequence does not span the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ubiquitin conjugating enzyme complex
cellular_component
Any complex that possesses ubiquitin conjugating enzyme activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
E2 complex
UBC13-MMS2 complex
cellular_component
A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains, which act as a signal to promote error-free DNA postreplication repair; in Saccharomyces the complex comprises Ubc13p and Mms2p.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:15772086
http://purl.org/obo/owl/PMID#PMID_15772086
type II fatty acid synthase complex
Type II refers to the type of fatty acid synthase. Type I is in a complex, type II is not.
cellular_component
OBSOLETE A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0716720094
http://purl.org/obo/owl/ISBN#ISBN_0716720094
ISBN:0471331309
http://purl.org/obo/owl/ISBN#ISBN_0471331309
PMID:12957385
http://purl.org/obo/owl/PMID#PMID_12957385
type II fatty acid synthase
type II FAS
type II FAS complex
cytosolic type II fatty acid synthase complex
cellular_component
OBSOLETE A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the cytosol.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0471331309
http://purl.org/obo/owl/ISBN#ISBN_0471331309
ISBN:0716720094
http://purl.org/obo/owl/ISBN#ISBN_0716720094
PMID:12957385
http://purl.org/obo/owl/PMID#PMID_12957385
cytosolic type II FAS complex
mitochondrial type II fatty acid synthase complex
Obsoleted because type II fatty acid synthases are not complexes
cellular_component
OBSOLETE A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the mitochondrion.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0471331309
http://purl.org/obo/owl/ISBN#ISBN_0471331309
PMID:12957385
http://purl.org/obo/owl/PMID#PMID_12957385
ISBN:0716720094
http://purl.org/obo/owl/ISBN#ISBN_0716720094
mitochondrial type II FAS complex
plastid type II fatty acid synthase complex
Obsoleted because type II fatty acid synthase is not a complex.
cellular_component
plastid type II FAS complex
OBSOLETE A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in a plastid.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0716720094
http://purl.org/obo/owl/ISBN#ISBN_0716720094
ISBN:0471331309
http://purl.org/obo/owl/ISBN#ISBN_0471331309
PMID:12957385
http://purl.org/obo/owl/PMID#PMID_12957385
RNA-directed RNA polymerase complex
cellular_component
A protein complex that possesses RNA-directed RNA polymerase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
nuclear RNA-directed RNA polymerase complex
cellular_component
A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain.
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:15607976
http://purl.org/obo/owl/PMID#PMID_15607976
RDRC
Rdr1 complex
viral RNA-directed RNA polymerase complex
cellular_component
A virus-specific protein complex that possesses RNA-dependent RNA polymerase activity and replicates the genome of an RNA virus.
PMID:15613301
http://purl.org/obo/owl/PMID#PMID_15613301
PMID:15574411
http://purl.org/obo/owl/PMID#PMID_15574411
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
MPF complex
cellular_component
A complex consisting of a Cdc2-class (also known as Cdc28) cyclin-dependent kinase and an M-phase cyclin such as S. pombe Cdc13. The MPF complex phosphorylates and activates the anaphase promoting complex (APC).
PMID:12045216
http://purl.org/obo/owl/PMID#PMID_12045216
Rad17 RFC-like complex
cellular_component
A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p.
PMID:14614842
http://purl.org/obo/owl/PMID#PMID_14614842
Rad17-RFC
Rad24p RFC-like complex
Rad17-RLC
RFC (Rad17)
Ctf18 RFC-like complex
cellular_component
A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p.
PMID:14614842
http://purl.org/obo/owl/PMID#PMID_14614842
RFC (Ctf18)
Ctf18-RLC
Ctf18-RFC
Elg1 RFC-like complex
cellular_component
Elg1-RFC
Elg1-RLC
RFC (Elg1)
A pentameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p.
PMID:14614842
http://purl.org/obo/owl/PMID#PMID_14614842
bursicon neuropeptide hormone complex
cellular_component
A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits.
GOC:rc
http://purl.org/obo/owl/GOC#GOC_rc
cytoplasmic vesicle
cellular_component
NIF_Subcellular:sao180601769
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao180601769
A vesicle formed of membrane or protein, found in the cytoplasm of a cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
gas vesicle
cellular_component
A hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps. By regulating their relative gas vesicle content aquatic microbes are able to perform vertical migrations.
PMID:8177173
http://purl.org/obo/owl/PMID#PMID_8177173
N-terminal protein acetyltransferase complex
cellular_component
NAT complex
A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
NatA complex
cellular_component
N-terminal acetyltransferase A complex
A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins.
PMID:12890471
http://purl.org/obo/owl/PMID#PMID_12890471
NatB complex
cellular_component
A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p.
PMID:12890471
http://purl.org/obo/owl/PMID#PMID_12890471
N-terminal acetyltransferase B complex
NatC complex
cellular_component
A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p.
PMID:12890471
http://purl.org/obo/owl/PMID#PMID_12890471
N-terminal acetyltransferase C complex
invertasome
cellular_component
A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts.
PMID:11114897
http://purl.org/obo/owl/PMID#PMID_11114897
PMID:9732277
http://purl.org/obo/owl/PMID#PMID_9732277
RecQ helicase-Topo III complex
cellular_component
Sgs1-Top3 complex
A complex containing a RecQ family helicase and a topoisomerase III homologue; may also include one or more additional proteins; conserved from E. coli to human.
PMID:15889139
http://purl.org/obo/owl/PMID#PMID_15889139
box C/D snoRNP complex
cellular_component
A ribonucleoprotein complex containing small nucleolar RNA of the box C/D type that can carry out ribose-2'-O-methylation of target RNAs.
PMID:17284456
http://purl.org/obo/owl/PMID#PMID_17284456
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
box C/D snoRNP ribose 2'-O methylase complex
PMID:17284456
http://purl.org/obo/owl/PMID#PMID_17284456
box C/D snoRNP ribose-2'-O-methyltransferase complex
PMID:17284456
http://purl.org/obo/owl/PMID#PMID_17284456
box H/ACA snoRNP complex
cellular_component
A box H/ACA RNP complex that is located in the nucleolus.
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
PMID:17284456
http://purl.org/obo/owl/PMID#PMID_17284456
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:20227365
http://purl.org/obo/owl/PMID#PMID_20227365
box H/ACA snoRNP pseudouridylase complex
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:17284456
http://purl.org/obo/owl/PMID#PMID_17284456
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
M band
cellular_component
M line
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
GOC:mtg_muscle
http://purl.org/obo/owl/GOC#GOC_mtg_muscle
Wikipedia:Sarcomere#bands
http://purl.org/obo/owl/Wikipedia#Wikipedia_Sarcomere#bands
mesophragma
M disc
midline
Dbf4-dependent protein kinase complex
cellular_component
DDK
Hsk1-Dfp1 kinase complex
A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins.
PMID:12045100
http://purl.org/obo/owl/PMID#PMID_12045100
Cdc7-Dbf4 complex
BRCA1-BARD1 complex
cellular_component
A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage.
PMID:12787778
http://purl.org/obo/owl/PMID#PMID_12787778
cullin-RING ubiquitin ligase complex
cellular_component
Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.
PMID:15571813
http://purl.org/obo/owl/PMID#PMID_15571813
PMID:15688063
http://purl.org/obo/owl/PMID#PMID_15688063
CRL complex
cullin-RING ligase
cullin complex
Cul2-RING ubiquitin ligase complex
cellular_component
CRL2 complex
CDL2 complex
cullin-RING ligase 2
ECS complex
SCF2 complex
A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.
PMID:15571813
http://purl.org/obo/owl/PMID#PMID_15571813
PMID:15688063
http://purl.org/obo/owl/PMID#PMID_15688063
EC2S complex
VBC complex
CBC complex
Cul3-RING ubiquitin ligase complex
cellular_component
SCF3 complex
BCR3 complex
BC3B complex
CDL3 complex
CRL3 complex
cullin-RING ligase 3
A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
PMID:15688063
http://purl.org/obo/owl/PMID#PMID_15688063
PMID:15571813
http://purl.org/obo/owl/PMID#PMID_15571813
Cul4A-RING ubiquitin ligase complex
cellular_component
VDC complex
CRL4 complex
CDL4 complex
DCX complex
cullin-RING ligase 4A
SCF4 complex
A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.
PMID:15688063
http://purl.org/obo/owl/PMID#PMID_15688063
PMID:15571813
http://purl.org/obo/owl/PMID#PMID_15571813
Cul4B-RING ubiquitin ligase complex
cellular_component
A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits.
PMID:15571813
http://purl.org/obo/owl/PMID#PMID_15571813
PMID:15688063
http://purl.org/obo/owl/PMID#PMID_15688063
cullin-RING ligase 4B
Cul5-RING ubiquitin ligase complex
cellular_component
A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.
PMID:15571813
http://purl.org/obo/owl/PMID#PMID_15571813
PMID:15688063
http://purl.org/obo/owl/PMID#PMID_15688063
cullin-RING ligase 5
CRL5 complex
CDL5 complex
EC2S complex
SCF5 complex
Cul7-RING ubiquitin ligase complex
cellular_component
SCF7 complex
A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein.
PMID:15688063
http://purl.org/obo/owl/PMID#PMID_15688063
PMID:15571813
http://purl.org/obo/owl/PMID#PMID_15571813
cullin-RING ligase 7
CDL7 complex
CRL7 complex
polyhedral organelle
cellular_component
An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
GOC:js
http://purl.org/obo/owl/GOC#GOC_js
PMID:11844753
http://purl.org/obo/owl/PMID#PMID_11844753
PMID:10498708
http://purl.org/obo/owl/PMID#PMID_10498708
PMID:12923081
http://purl.org/obo/owl/PMID#PMID_12923081
carboxysome
cellular_component
Wikipedia:Carboxysome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Carboxysome
An organelle found in the Cyanobacteria consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide including mechanisms for the concentration of carbonate to increase the efficiency of fixation under low-carbon dioxide conditions.
GOC:js
http://purl.org/obo/owl/GOC#GOC_js
PMID:8491708
http://purl.org/obo/owl/PMID#PMID_8491708
PMID:8157606
http://purl.org/obo/owl/PMID#PMID_8157606
ethanolamine degradation polyhedral organelle
cellular_component
An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase.
PMID:11844753
http://purl.org/obo/owl/PMID#PMID_11844753
GOC:js
http://purl.org/obo/owl/GOC#GOC_js
ethanolamine metabolosome
propanediol degradation polyhedral organelle
cellular_component
An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of 1,2-propanediol whose purpose is the protection of the rest of the cell from the toxic propionaldehyde product of the enzyme diol dehydratase.
PMID:12923081
http://purl.org/obo/owl/PMID#PMID_12923081
PMID:11844753
http://purl.org/obo/owl/PMID#PMID_11844753
PMID:10498708
http://purl.org/obo/owl/PMID#PMID_10498708
GOC:js
http://purl.org/obo/owl/GOC#GOC_js
myosin IV complex
cellular_component
A myosin complex containing one or more class IV myosin heavy chains and associated light chains; myosin IV is relatively uncharacterized, but is predicted to have a single motor domain, one IQ motif and a tail with a Myosin Tail Homology (myTH4) domain homologous to that in the tails of myosins VII and XV.
URL:http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
myosin V complex
cellular_component
A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localization and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region.
URL:http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
myosin VI complex
cellular_component
A myosin complex containing one or more class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments.
URL:http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
myosin VII complex
cellular_component
A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain.
URL:http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
myosin VIII complex
cellular_component
A myosin complex containing a dimer of class VIII myosin heavy chains and associated light chains. Myosin VIII is predicted to be dimeric, and contain an unusual 100-190 residue N-terminal extension prior to their motor domains, 3-4 IQ motifs, a short region (~70 residues) of predicted alpha-helical coiled coil and a C-terminal domain.
URL:http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
myosin IX complex
cellular_component
A myosin complex containing a class IX myosin heavy chain and associated light chains. Myosin IX is monomeric with a motor domain containing an N-terminal extension and an insert in the actin binding interface, followed by four to six IQ motifs and a tail region that contains a zinc binding motif and a domain with homology to GTPase activating proteins (GAPs) of the Rho family of G-proteins.
URL:http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
myosin X complex
cellular_component
A myosin complex containing one or more class X myosin heavy chains and associated light chains.
URL:http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
myosin XI complex
cellular_component
A myosin complex containing a dimer of class XI myosin heavy chains and associated light chains. Myosin XI heavy chain sizes are similar in molecular structure to the class V myosins with 5 to 6 IQ motifs and tail regions with predicted coiled coil domains (forming dimeric molecules) and large C-terminal regions.
URL:http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
myosin XII complex
cellular_component
A myosin complex containing one or more class XII myosin heavy chains and associated light chains; myosin XII contains a large tail region with two MyTH4 domains and a short region of coiled coil.
URL:http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
myosin XIII complex
cellular_component
A myosin complex containing one or more class XIII myosin heavy chains and associated light chains.
URL:http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
myosin XIV complex
cellular_component
A myosin complex containing a class XIV myosin heavy chain and associated light chains; myosin XIV heavy chains are the simplest known, containing a motor domain, no classic IQ motif and variable length tails.
URL:http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
myosin XV complex
cellular_component
A myosin complex containing a class XV myosin heavy chain and associated light chains. Myosin XV is single headed, and has a large extension (1200aa) at the N-terminus of the motor domain, two IQ motifs and a tail with a similar domain structure to that of the tail of myosin VII.
URL:http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
myosin XVI complex
cellular_component
A myosin complex containing a class XVI myosin heavy chains and associated light chains; myosin XVI heavy chains contain ankyrin repeat.
PMID:11294886
http://purl.org/obo/owl/PMID#PMID_11294886
URL:http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
myosin XVII complex
cellular_component
A myosin complex containing one or more class XVII myosin heavy chains and associated light chains.
URL:http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
myosin XVIII complex
cellular_component
A myosin complex containing a class XVIII myosin heavy chain and associated light chains; myosin XVIII heavy chains contain an N-terminal PDZ domain.
PMID:11294886
http://purl.org/obo/owl/PMID#PMID_11294886
TRAMP complex
cellular_component
Trf4 poly(A) polymerase complex
Wikipedia:TRAMP_complex
http://purl.org/obo/owl/Wikipedia#Wikipedia_TRAMP_complex
Trf4p-Air2p-Mtr4p polyadenylation complex
TRAMP5 complex
Trf4 complex
A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3'-end processing and in RNA surveillance and quality control.
PMID:15173578
http://purl.org/obo/owl/PMID#PMID_15173578
PMID:15935758
http://purl.org/obo/owl/PMID#PMID_15935758
PMID:15828860
http://purl.org/obo/owl/PMID#PMID_15828860
PMID:16373491
http://purl.org/obo/owl/PMID#PMID_16373491
PMID:15935759
http://purl.org/obo/owl/PMID#PMID_15935759
PMID:16431988
http://purl.org/obo/owl/PMID#PMID_16431988
PMID:16374505
http://purl.org/obo/owl/PMID#PMID_16374505
PMID:16973437
http://purl.org/obo/owl/PMID#PMID_16973437
PMID:17410208
http://purl.org/obo/owl/PMID#PMID_17410208
PMID:17652137
http://purl.org/obo/owl/PMID#PMID_17652137
TRAMP4 complex
Tea1 cell-end complex
cellular_component
A high molecular weight complex characterized in S. pombe containing the cell-end anchoring protein Tea1. This complex is transported to the cell ends by microtubules and is involved in bipolar growth and the maintennce of normal cell polarity.
PMID:15936270
http://purl.org/obo/owl/PMID#PMID_15936270
mannosyltransferase complex
cellular_component
A complex that posseses mannosyltransferase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
dolichyl-phosphate-mannose-protein mannosyltransferase complex
cellular_component
PMT family mannosyltransferase complex
A complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity; usually includes members of the PMT1 and PMT2 protein subfamilies.
PMID:15948957
http://purl.org/obo/owl/PMID#PMID_15948957
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
protein O-mannosyltransferase complex
SUMO activating enzyme complex
cellular_component
A conserved heterodimeric complex with SUMO activating enzyme activity.
PMID:15601841
http://purl.org/obo/owl/PMID#PMID_15601841
SAE
SUMO E1 activator enzyme complex
Mis6-Sim4 complex
cellular_component
A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:12719471
http://purl.org/obo/owl/PMID#PMID_12719471
PMID:15897182
http://purl.org/obo/owl/PMID#PMID_15897182
Sim4 complex
Mis6 centromere subcomplex
Mis6-Mal2-Sim4 centromere complex
PMID:21445296
http://purl.org/obo/owl/PMID#PMID_21445296
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
motile primary cilium
Note that this term should not be confused with 'motile cilium ; GO:0031514': Motile primary cilia are distinct from motile cilia (GO:0031514) that are typically present on epithelial cells in multiple copies and move in a whip-like, as opposed to rotational, manner.
cellular_component
motile primary cilia
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
A primary cilium which may contain a variable array of axonemal microtubules and also contains molecular motors. Motile primary cilia display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization.
PMID:20144998
http://purl.org/obo/owl/PMID#PMID_20144998
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
PMID:17009929
http://purl.org/obo/owl/PMID#PMID_17009929
GOC:dgh
http://purl.org/obo/owl/GOC#GOC_dgh
nodal cilium
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
nonmotile primary cilium
cellular_component
nonmotile primary cilia
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
immotile primary cilium
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
sensory cilium
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules.
PMID:17009929
http://purl.org/obo/owl/PMID#PMID_17009929
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
PMID:20144998
http://purl.org/obo/owl/PMID#PMID_20144998
GOC:dgh
http://purl.org/obo/owl/GOC#GOC_dgh
motile cilium
Note that this term should not be confused with 'motile primary cilium ; GO:0031512': Motile cilia are distinct from motile primary cilia (GO:0031512) that are typically present during embryogenesis in a single copy per cell, affect asymmetric body plan organization, and move in a rotational manner, as opposed to a whip-like, manner.
cellular_component
motile secondary cilium
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles.
PMID:20144998
http://purl.org/obo/owl/PMID#PMID_20144998
PMID:17009929
http://purl.org/obo/owl/PMID#PMID_17009929
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
GOC:dgh
http://purl.org/obo/owl/GOC#GOC_dgh
motile cilia
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
tRNA (m1A) methyltransferase complex
cellular_component
A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer.
PMID:10779558
http://purl.org/obo/owl/PMID#PMID_10779558
PMID:14739239
http://purl.org/obo/owl/PMID#PMID_14739239
CBF3 complex
cellular_component
A multisubunit protein complex that binds to centromeric DNA and initiates kinetochore assembly. In yeast, this complex consists of four subunits, namely Ctf13p, Skp1p, Cep3p and Cbf2p.
PMID:13679521
http://purl.org/obo/owl/PMID#PMID_13679521
PMID:9407032
http://purl.org/obo/owl/PMID#PMID_9407032
PcG protein complex
cellular_component
A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.
PMID:9372908
http://purl.org/obo/owl/PMID#PMID_9372908
Polycomb Group protein complex
plasma membrane of cell tip
cellular_component
The portion of the plasma membrane surrounding the cell tip.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
spitzenkorper
cellular_component
Structure within the hyphal tip of filamentous fungi that acts as an organizing center for hyphal tip growth; may function to supply vesicles to the elongating tip and/or to organize cytoskeletal microfilaments.
PMID:15701784
http://purl.org/obo/owl/PMID#PMID_15701784
PMID:15976451
http://purl.org/obo/owl/PMID#PMID_15976451
cell envelope Sec protein transport complex
Note that this term represents the protein complex involved in transport of proteins across the cytoplasmic membrane. For proteins involved in bacterial Type II secretion across the outer membrane, consider annotating to 'type II protein secretion complex ; GO:0015628'. For proteins involved in Sec-complex dependent translocation into the eukaryotic endoplasmic reticulum, consider annotating to 'endoplasmic reticulum Sec complex ; GO:0031205'.
cellular_component
Sec translocation complex
plasma membrane Sec complex
Sec secretion complex
A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:15223057
http://purl.org/obo/owl/PMID#PMID_15223057
Sec complex
Myb complex
cellular_component
Myeloblastosis proto-oncogene protein complex
A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression.
PMID:12490953
http://purl.org/obo/owl/PMID#PMID_12490953
PMID:15545624
http://purl.org/obo/owl/PMID#PMID_15545624
brush border membrane
cellular_component
The portion of the plasma membrane surrounding the brush border.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
filopodium membrane
cellular_component
The portion of the plasma membrane surrounding a filopodium.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
microvillus membrane
cellular_component
The portion of the plasma membrane surrounding a microvillus.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mRNA cap methyltransferase complex
cellular_component
mRNA (guanine-N7) methyltransferase complex
A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping.
PMID:10347220
http://purl.org/obo/owl/PMID#PMID_10347220
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
mRNA capping enzyme complex
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
cellular bud neck polarisome
cellular_component
Protein complex that has a role in determining cell polarity, found at the neck of a fungal bud before and during cytokinesis.
PMID:9632790
http://purl.org/obo/owl/PMID#PMID_9632790
cellular bud tip polarisome
cellular_component
Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal bud.
PMID:9632790
http://purl.org/obo/owl/PMID#PMID_9632790
hyphal tip polarisome
cellular_component
Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal hypha.
PMID:15976451
http://purl.org/obo/owl/PMID#PMID_15976451
mating projection tip polarisome
cellular_component
Protein complex that has a role in determining cell polarity, found at the tip of the mating projection in unicellular fungi exposed to mating pheromone.
PMID:14734532
http://purl.org/obo/owl/PMID#PMID_14734532
AMP-activated protein kinase complex
cellular_component
Snf1 kinase complex
AMPK complex
A protein complex that possesses AMP-dependent protein kinase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Snf1 serine/threonine protein kinase complex
5'-AMP-activated protein kinase complex
centrosomal corona
Note that the centrosomal corona has been observed in Dictyostelium, and is the functional equivalent of pericentriolar material.
cellular_component
An amorphous structure surrounding the core of the centrosome, from which microtubules are nucleated; contains gamma-tubulin.
GOC:kp
http://purl.org/obo/owl/GOC#GOC_kp
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
neuromuscular junction
cellular_component
Wikipedia:Neuromuscular_junction
http://purl.org/obo/owl/Wikipedia#Wikipedia_Neuromuscular_junction
NIF_Subcellular:sao1124888485
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1124888485
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible of the muscle contraction.
GOC:nln
http://purl.org/obo/owl/GOC#GOC_nln
nuclear proteasome complex
cellular_component
A proteasome found in the nucleus of a cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ER proteasome complex
cellular_component
A proteasome found in the endoplasmic reticulum of a cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cytosolic proteasome complex
cellular_component
A proteasome complex found in the cytosol of a cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
nuclear proteasome regulatory particle
cellular_component
The regulatory subcomplex of a proteasome located in the nucleus of a cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ER proteasome regulatory particle
cellular_component
The regulatory subcomplex of a proteasome located in the endoplasmic reticulum of a cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cytosolic proteasome regulatory particle
cellular_component
A multisubunit complex located in the cytosol of a cell, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
nuclear proteasome core complex
cellular_component
The core complex of a proteasome located in the nucleus of a cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ER proteasome core complex
cellular_component
The core complex of a proteasome located in the endoplasmic reticulum of a cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cytosolic proteasome core complex
cellular_component
The core complex of a proteasome located in the cytosol of a cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
nuclear proteasome core complex, alpha-subunit complex
cellular_component
The subunits forming the outer ring of the core complex of a proteasome located in the nucleus of a cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ER proteasome core complex, alpha-subunit complex
cellular_component
The subunits forming the outer ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cytosolic proteasome core complex, alpha-subunit complex
cellular_component
The proteasome core subcomplex that constitutes the two outer rings of the cytosolic proteasome core complex.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
nuclear proteasome core complex, beta-subunit complex
cellular_component
The subunits forming the inner ring of the core complex of a proteasome located in the nucleus of a cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ER proteasome core complex, beta-subunit complex
cellular_component
The subunits forming the inner ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cytosolic proteasome core complex, beta-subunit complex
cellular_component
The proteasome core subcomplex that constitutes the two inner rings of the cytosolic proteasome core complex.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
nuclear proteasome regulatory particle, base subcomplex
cellular_component
The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the nucleus of a cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ER proteasome regulatory particle, base subcomplex
cellular_component
The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the endoplasmic reticulum of a cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cytosolic proteasome regulatory particle, base subcomplex
cellular_component
The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex located in the cytosol of the cell.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
nuclear proteasome regulatory particle, lid subcomplex
cellular_component
The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the nucleus of a cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ER proteasome regulatory particle, lid subcomplex
cellular_component
The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the endoplasmic reticulum of a cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cytosolic proteasome regulatory particle, lid subcomplex
cellular_component
The subcomplex of the cytosolic proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
spindle pole centrosome
cellular_component
A centrosome from which one pole of a mitotic or meiotic spindle is organized.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
NMS complex
cellular_component
Ndc80-MIND-Spc7 complex
A supercomplex formed by the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) with additional proteins at the kinetochores of condensed nuclear chromosomes.
PMID:16079914
http://purl.org/obo/owl/PMID#PMID_16079914
nuclear centromeric heterochromatin
cellular_component
nuclear centric heterochromatin
A region of heterochromatin located near the centromere of a chromosome in the nucleus.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
xanthophore
Note that this term refers to a subcellular structure, and should not be confused with the specialized cells known as xanthophores, which produce yellow pigment and are found in fish and amphibian skin. Note that several terms in the biological process ontology ('xanthophore differentiation ; GO:0050936' and its children) refer to xanthophores in the sense of pigment-producing cells.
cellular_component
A chromatophore containing yellow pigment.
ISBN:0395825172
http://purl.org/obo/owl/ISBN#ISBN_0395825172
A band
cellular_component
Wikipedia:Sarcomere#bands
http://purl.org/obo/owl/Wikipedia#Wikipedia_Sarcomere#bands
transverse disc
anisotropic disc
Q disc
A disc
The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.
ISBN:0321204131
http://purl.org/obo/owl/ISBN#ISBN_0321204131
H zone
cellular_component
H disc
H band
Wikipedia:Sarcomere#bands
http://purl.org/obo/owl/Wikipedia#Wikipedia_Sarcomere#bands
A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments.
ISBN:0321204131
http://purl.org/obo/owl/ISBN#ISBN_0321204131
GOC:mtg_muscle
http://purl.org/obo/owl/GOC#GOC_mtg_muscle
I band
cellular_component
Wikipedia:Sarcomere#bands
http://purl.org/obo/owl/Wikipedia#Wikipedia_Sarcomere#bands
isotropic disc
I disc
A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.
ISBN:0321204131
http://purl.org/obo/owl/ISBN#ISBN_0321204131
J disc
plasma membrane-derived thylakoid membrane
cellular_component
The pigmented membrane of a plasma membrane-derived thylakoid.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
plasma membrane thylakoid membrane
G-protein beta/gamma-subunit complex
See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'.
cellular_component
heterotrimeric G-protein GTPase, beta-subunit
The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
G-beta/G-gamma complex
haptoglobin-hemoglobin complex
cellular_component
A protein complex formed by the stable binding of a haptoglobin to hemoglobin.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Tic complex
cellular_component
The translocon of the inner envelope of chloroplasts, which facilitates the import of proteins across the chloroplast inner membrane.
PMID:12393016
http://purl.org/obo/owl/PMID#PMID_12393016
PMID:12180471
http://purl.org/obo/owl/PMID#PMID_12180471
chloroplast inner membrane translocase complex
chromoplast envelope
cellular_component
The double lipid bilayer enclosing the chromoplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
GOC:pz
http://purl.org/obo/owl/GOC#GOC_pz
chromoplast inner membrane
cellular_component
The inner, i.e. lumen-facing, lipid bilayer of the chromoplast envelope; also faces the chromoplast stroma.
GOC:pz
http://purl.org/obo/owl/GOC#GOC_pz
chromoplast outer membrane
cellular_component
The outer, i.e. cytoplasm-facing, lipid bilayer of the chromoplast envelope.
GOC:pz
http://purl.org/obo/owl/GOC#GOC_pz
early endosome membrane
cellular_component
The lipid bilayer surrounding an early endosome.
GOC:pz
http://purl.org/obo/owl/GOC#GOC_pz
late endosome membrane
cellular_component
The lipid bilayer surrounding a late endosome.
GOC:pz
http://purl.org/obo/owl/GOC#GOC_pz
microbody membrane
cellular_component
The lipid bilayer surrounding a microbody.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
endosome lumen
cellular_component
NIF_Subcellular:sao1547508851
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1547508851
The volume enclosed by the membrane of an endosome.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
early endosome lumen
cellular_component
The volume enclosed by the membrane of an early endosome.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
late endosome lumen
cellular_component
The volume enclosed by the membrane of a late endosome.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
microbody lumen
cellular_component
The volume enclosed by the membranes of a microbody.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
glyoxysomal lumen
cellular_component
The volume enclosed by the membranes of a glyoxysome.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cytostome
cellular_component
Stable, specialized structure for the ingestion of food by the cell into phagosomes.
PMID:10503189
http://purl.org/obo/owl/PMID#PMID_10503189
Wikipedia:Cytostome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Cytostome
cytoproct
cellular_component
Stable, specialized structure for extrusion of waste by the cell into the surrounding medium.
PMID:10503189
http://purl.org/obo/owl/PMID#PMID_10503189
oral apparatus
Note that this term refers to a subcellular structure characteristic of ciliate protozoans, and should not be confused with oral anatomical structures of multicellular animals.
cellular_component
Complex basket- or funnel-like structure used by the cell to collect food and channel it to the cytostome; includes specialized sub-structures made up of closely-spaced cilia and underlying basal bodies and fibrillar systems.
PMID:10503189
http://purl.org/obo/owl/PMID#PMID_10503189
contractile vacuole pore
cellular_component
Stable structure that regulates the flow of liquid between the contractile vacuole and the surrounding medium.
PMID:10503189
http://purl.org/obo/owl/PMID#PMID_10503189
TORC1 complex
cellular_component
dTORC1
PMID:17183368
http://purl.org/obo/owl/PMID#PMID_17183368
dTOR/dRaptor complex
PMID:17183368
http://purl.org/obo/owl/PMID#PMID_17183368
mTORC1
PMID:18765678
http://purl.org/obo/owl/PMID#PMID_18765678
PMID:21548787
http://purl.org/obo/owl/PMID#PMID_21548787
TOR complex 1
TORC 1 complex
TORC1
PMID:21548787
http://purl.org/obo/owl/PMID#PMID_21548787
A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p.
PMID:16469695
http://purl.org/obo/owl/PMID#PMID_16469695
PMID:21548787
http://purl.org/obo/owl/PMID#PMID_21548787
PMID:15780592
http://purl.org/obo/owl/PMID#PMID_15780592
GOC:jh
http://purl.org/obo/owl/GOC#GOC_jh
nutrient sensitive complex
rapamycin and nutrient-sensitive TOR complex
PMID:21548787
http://purl.org/obo/owl/PMID#PMID_21548787
TORC2 complex
cellular_component
A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p.
PMID:14736892
http://purl.org/obo/owl/PMID#PMID_14736892
PMID:15780592
http://purl.org/obo/owl/PMID#PMID_15780592
PMID:16469695
http://purl.org/obo/owl/PMID#PMID_16469695
PMID:21548787
http://purl.org/obo/owl/PMID#PMID_21548787
GOC:jh
http://purl.org/obo/owl/GOC#GOC_jh
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
TORC 2 complex
TORC2
PMID:21548787
http://purl.org/obo/owl/PMID#PMID_21548787
TOR complex 2
mTORC2
PMID:21548787
http://purl.org/obo/owl/PMID#PMID_21548787
PMID:20496258
http://purl.org/obo/owl/PMID#PMID_20496258
rapamycin and nutrient-insensitive TOR complex
PMID:21548787
http://purl.org/obo/owl/PMID#PMID_21548787
telomeric heterochromatin
cellular_component
telomeric chromatin
GOC:pr
http://purl.org/obo/owl/GOC#GOC_pr
Heterochromatic regions of the chromosome found at the telomeres.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mating-type region heterochromatin
cellular_component
Heterochromatic regions of the chromosome found at silenced mating-type loci.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
filamentous actin
Note that this term refers only to the actin portion of a microfilament, and does not encompass associated proteins. See also the cellular component term 'actin filament ; GO:0005884'.
cellular_component
Wikipedia:Actin
http://purl.org/obo/owl/Wikipedia#Wikipedia_Actin
F-actin
A two-stranded helical polymer of the protein actin.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
i-AAA complex
cellular_component
Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases.
PMID:16267274
http://purl.org/obo/owl/PMID#PMID_16267274
PMID:16247555
http://purl.org/obo/owl/PMID#PMID_16247555
nuclear membrane
cellular_component
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
GOC:pz
http://purl.org/obo/owl/GOC#GOC_pz
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
NIF_Subcellular:sao1687101204
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1687101204
mitochondrial membrane
cellular_component
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
organelle envelope
cellular_component
A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:pz
http://purl.org/obo/owl/GOC#GOC_pz
organelle outer membrane
cellular_component
The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
chloroplast membrane
cellular_component
Wikipedia:Chloroplast_membrane
http://purl.org/obo/owl/Wikipedia#Wikipedia_Chloroplast_membrane
Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:pz
http://purl.org/obo/owl/GOC#GOC_pz
organelle envelope lumen
cellular_component
The region between the inner and outer lipid bilayers of an organelle envelope.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
organelle intermembrane space
chloroplast intermembrane space
cellular_component
chloroplast envelope lumen
The region between the inner and outer lipid bilayers of a chloroplast envelope.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
chromoplast intermembrane space
cellular_component
The region between the inner and outer lipid bilayers of a chromoplast envelope.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
chromoplast envelope lumen
membrane-enclosed lumen
cellular_component
The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
envelope
cellular_component
A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers.
GOC:pz
http://purl.org/obo/owl/GOC#GOC_pz
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
plastid thylakoid
cellular_component
Any thylakoid within a plastid.
GOC:pz
http://purl.org/obo/owl/GOC#GOC_pz
thylakoid lumen
cellular_component
The volume enclosed by a thylakoid membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:pz
http://purl.org/obo/owl/GOC#GOC_pz
plastid thylakoid lumen
cellular_component
The volume enclosed by a plastid thylakoid membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
plasma membrane-derived thylakoid lumen
cellular_component
The volume enclosed by a plasma membrane-derived thylakoid.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
plasma membrane thylakoid lumen
nuclear lumen
cellular_component
The volume enclosed by the nuclear inner membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:pz
http://purl.org/obo/owl/GOC#GOC_pz
vesicle
cellular_component
Any small, fluid-filled, spherical organelle enclosed by membrane or protein.
GOC:pz
http://purl.org/obo/owl/GOC#GOC_pz
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
NIF_Subcellular:sao221389602
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao221389602
Wikipedia:Vesicle_(biology)
http://purl.org/obo/owl/Wikipedia#Wikipedia_Vesicle_(biology)
vesicle lumen
cellular_component
The volume enclosed by the membrane or protein that forms a vesicle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
NIF_Subcellular:sao797538226
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao797538226
organelle subcompartment
Note that this term refers to membrane-bounded compartments that are not considered organelles in their own right, but form parts of larger organelles.
cellular_component
A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle.
GOC:pz
http://purl.org/obo/owl/GOC#GOC_pz
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
suborganelle compartment
Golgi cisterna
cellular_component
Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
proteinoplast
cellular_component
Wikipedia:Proteinoplast
http://purl.org/obo/owl/Wikipedia#Wikipedia_Proteinoplast
A leucoplast in which protein is stored.
GOC:pz
http://purl.org/obo/owl/GOC#GOC_pz
membrane-bounded vesicle
cellular_component
Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
membrane-enclosed vesicle
interleukin-28 receptor complex
cellular_component
A protein complex that binds interleukin-28 and interleukin-29. Composed of two subunits, IL-28R alpha and IL-10R beta.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
IL-28 receptor complex
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
early phagosome
cellular_component
early phagocytic vesicle
A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis.
PMID:12388753
http://purl.org/obo/owl/PMID#PMID_12388753
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
phagolysosome
cellular_component
A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:12388753
http://purl.org/obo/owl/PMID#PMID_12388753
Wikipedia:Phagolysosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Phagolysosome
late phagocytic vesicle
late phagosome
mitochondrial cloud
cellular_component
A prominent mass in the cytoplasm of previtellogenic oocytes. The cloud contains both mitochondria and electron-dense granulofibrillar material (GFM) and is the source of germinal granule material.
PMID:6541166
http://purl.org/obo/owl/PMID#PMID_6541166
Balbiani body
NELF complex
cellular_component
A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing.
PMID:12612062
http://purl.org/obo/owl/PMID#PMID_12612062
negative elongation factor complex
integrator complex
cellular_component
A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II.
PMID:16239144
http://purl.org/obo/owl/PMID#PMID_16239144
small-subunit processome
cellular_component
SSU processome
small subunit processome
A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
PMID:12068309
http://purl.org/obo/owl/PMID#PMID_12068309
PMID:12957375
http://purl.org/obo/owl/PMID#PMID_12957375
PMID:15120992
http://purl.org/obo/owl/PMID#PMID_15120992
PMID:15590835
http://purl.org/obo/owl/PMID#PMID_15590835
DSIF complex
cellular_component
Spt5-Spt4 complex
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
Spt4-Spt5 complex
DRB sensitivity inducing factor complex
A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes.
PMID:12242279
http://purl.org/obo/owl/PMID#PMID_12242279
PMID:12653964
http://purl.org/obo/owl/PMID#PMID_12653964
PMID:12676794
http://purl.org/obo/owl/PMID#PMID_12676794
PMID:16581788
http://purl.org/obo/owl/PMID#PMID_16581788
PMID:19460865
http://purl.org/obo/owl/PMID#PMID_19460865
5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex
guanyl-nucleotide exchange factor complex
cellular_component
A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
micropexophagy-specific membrane apparatus
cellular_component
A membrane-bounded flattened sac that is formed during micropexophagy between the membrane tips of an engulfing vacuole, completing the engulfment and sequestration of peroxisomes from the cytosol, and forming a micropexophagic body within the lumen of the vacuole.
PMID:15563611
http://purl.org/obo/owl/PMID#PMID_15563611
MIPA
micropexophagic apparatus
mitosome
cellular_component
crypton
Wikipedia:Mitosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Mitosome
A double-membrane-bounded organelle that functions in iron-sulfur protein maturation; evolutionarily derived from mitochondria.
PMID:10361303
http://purl.org/obo/owl/PMID#PMID_10361303
PMID:14614504
http://purl.org/obo/owl/PMID#PMID_14614504
bleb
cellular_component
Wikipedia:Bleb_(cell_biology)
http://purl.org/obo/owl/Wikipedia#Wikipedia_Bleb_(cell_biology)
A cell extension characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusions.
PMID:12083798
http://purl.org/obo/owl/PMID#PMID_12083798
PMID:16624291
http://purl.org/obo/owl/PMID#PMID_16624291
Type IV site-specific deoxyribonuclease complex
cellular_component
Type IV restriction enzyme complex
A complex consisting of two proteins which acts as an endonuclease in DNA sequences containing a specific modified recognition site. Modifications may include methylation, hydroxymethylation, and glucosyl-hydroxymethylation.
PMID:12654995
http://purl.org/obo/owl/PMID#PMID_12654995
SMC loading complex
cellular_component
SCC2/SCC4 loading complex
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
chromatin loading complex
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
cohesin loading complex
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
A protein complex required for the loading of a structural maintenance of chromosome (SMC) complex, such as cohesin, condensin or SMC5/SMC6, onto DNA. Appears to be eukaryotically conserved.
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
PMID:10882066
http://purl.org/obo/owl/PMID#PMID_10882066
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
horsetail-astral microtubule array
cellular_component
HAA
An array of astral microtubules that emanates from the spindle pole body during meiosis and facilitates horsetail nuclear movement.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:16111942
http://purl.org/obo/owl/PMID#PMID_16111942
deep fiber
cellular_component
deep fibre
Inward projections of the cytoskeletal structures of the oral apparatus, which form a fiber that extends past the cytostome into the cytoplasm.
PMID:10503189
http://purl.org/obo/owl/PMID#PMID_10503189
eisosome
cellular_component
Any of the large immobile protein assemblies at the plasma membrane that mark endocytic sites. In yeast, S. cerevisiae, these structures are primarily composed of Pil1p and Lsp1p.
PMID:16496001
http://purl.org/obo/owl/PMID#PMID_16496001
Wikipedia:Eisosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Eisosome
dense core granule membrane
cellular_component
The lipid bilayer surrounding a dense core granule.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
dense core vesicle membrane
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
chromosome passenger complex
cellular_component
A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin.
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:19570910
http://purl.org/obo/owl/PMID#PMID_19570910
PMID:16824200
http://purl.org/obo/owl/PMID#PMID_16824200
chromosomal passenger complex
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
CPC complex
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
CPC
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
4-aminobutyrate transaminase complex
cellular_component
GABA-T complex
GABA transaminase complex
ABAT complex
A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:15528998
http://purl.org/obo/owl/PMID#PMID_15528998
mitotic septin complex
cellular_component
A heterooligomeric septin complex that acts during mitotic cell division.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:16009555
http://purl.org/obo/owl/PMID#PMID_16009555
meiotic septin complex
cellular_component
A heterooligomeric septin complex that acts during meiotic cell division.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:16009555
http://purl.org/obo/owl/PMID#PMID_16009555
cell division site
Note that this term refers to the future site of division in a cell that has not yet divided.
cellular_component
cell division plane
The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. The cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane. The mitotic, or meiotic, spindle is aligned perpendicular to the division plane.
PMID:12101122
http://purl.org/obo/owl/PMID#PMID_12101122
GOC:ns
http://purl.org/obo/owl/GOC#GOC_ns
PMID:15380095
http://purl.org/obo/owl/PMID#PMID_15380095
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
cleavage furrow
cellular_component
Wikipedia:Cleavage_furrow
http://purl.org/obo/owl/Wikipedia#Wikipedia_Cleavage_furrow
In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists.
ISBN:0805319409
http://purl.org/obo/owl/ISBN#ISBN_0805319409
cell division site part
cellular_component
cell division plane part
Any constituent part of the cell division plane, the eventual plane of cell division in a dividing cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
septin cytoskeleton
cellular_component
The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
prospore contractile ring
cellular_component
meiotic contractile ring
A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane of the prospore envelope in meiotic cells in preparation for completing cytokinesis.
PMID:16009555
http://purl.org/obo/owl/PMID#PMID_16009555
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
cytokinetic ring
actomyosin ring
septin band
cellular_component
A diffuse ring composed of a series of septin bars that run parallel to the long axis of the cell. This type of septin structure has been observed in a number of locations associated with polarized grown and/or deposition of new membrane, but not with cytokinesis, such as at the shmoo (mating projection) neck, at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously.
PMID:16151244
http://purl.org/obo/owl/PMID#PMID_16151244
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
septin cap
cellular_component
A faint structure formed of septins found at the leading edge of growth in germ tubes and hyphae in fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol.
PMID:16151244
http://purl.org/obo/owl/PMID#PMID_16151244
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
septin filament array
cellular_component
Arrays of septin filaments, or bars, found in a series of filamentous structures. Such structures have been observed in the prospore membrane during spore formation in S. cerevisiae and in the chlamydospore membrane during chlamydospore formation in C. albicans.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:16151244
http://purl.org/obo/owl/PMID#PMID_16151244
septin bar
cleavage apparatus septin structure
cellular_component
Any of a series of structures composed of septins and septin-associated proteins localized to the cleavage plane which are involved in cytokinesis.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:12101122
http://purl.org/obo/owl/PMID#PMID_12101122
PMID:16009555
http://purl.org/obo/owl/PMID#PMID_16009555
PMID:15774761
http://purl.org/obo/owl/PMID#PMID_15774761
mating projection septin band
cellular_component
A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the neck of a shmoo (mating projection).
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:16151244
http://purl.org/obo/owl/PMID#PMID_16151244
hyphal septin band
cellular_component
A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:16151244
http://purl.org/obo/owl/PMID#PMID_16151244
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
hyphal septin cap
cellular_component
A faint structure formed of septins found at the leading edge of growth in hyphae of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol.
PMID:16151244
http://purl.org/obo/owl/PMID#PMID_16151244
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
prospore septin filament array
cellular_component
Arrays of septin filaments, or bars, found in a series of filamentous structures; observed in the prospore membrane during spore formation.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:16151244
http://purl.org/obo/owl/PMID#PMID_16151244
chlamydospore septin filament array
cellular_component
Arrays of septin filaments, or bars, found in a series of filamentous structures. Observed in the chlamydospore membrane during chlamydospore formation.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:16151244
http://purl.org/obo/owl/PMID#PMID_16151244
septin patch
This term was made obsolete because it was added in error; it does not refer to a normal subcellular structure.
cellular_component
OBSOLETE. An amorphous-appearing accumulation of septin proteins at the future site of cytokinesis.
PMID:16009555
http://purl.org/obo/owl/PMID#PMID_16009555
hyphal septin ring
cellular_component
A tight ring-shaped structure that forms in the division plane within hyphae of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:16151244
http://purl.org/obo/owl/PMID#PMID_16151244
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
prospore septin ring
cellular_component
A tight ring-shaped structure that forms in the division plane at the site of cytokinesis in a prospore; composed of septins as well as septin-associated proteins.
PMID:16151244
http://purl.org/obo/owl/PMID#PMID_16151244
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
pseudohyphal septin ring
cellular_component
A tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection; composed of septins as well as septin-associated proteins.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:16151244
http://purl.org/obo/owl/PMID#PMID_16151244
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
germ tube septin cap
cellular_component
A faint structure formed of septins found at the leading edge of growth in germ tubes of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol.
PMID:16151244
http://purl.org/obo/owl/PMID#PMID_16151244
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
germ tube septin ring
cellular_component
A tight ring-shaped structure that forms in the division plane within the germ tube of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins.
PMID:16151244
http://purl.org/obo/owl/PMID#PMID_16151244
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
septin collar
cellular_component
A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell.
PMID:16009555
http://purl.org/obo/owl/PMID#PMID_16009555
PMID:16151244
http://purl.org/obo/owl/PMID#PMID_16151244
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
cellular bud neck septin collar
cellular_component
A tubular structure with flared ends, shaped like an hourglass and composed of highly ordered arrays of septin filaments, that forms at the bud neck of a dividing cell. In S. cerevisiae, this structure is located at the bud neck throughout most of the cell cycle and the septins are fixed within the structure, not exchanging with soluble septins. This septin structure acts as a scaffold for other proteins that function at the bud neck.
PMID:16009555
http://purl.org/obo/owl/PMID#PMID_16009555
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
mating projection septin ring
cellular_component
A septin ring, i.e. a ring-shaped structure composed of septins and septin-associated proteins, located at the neck of a shmoo (mating projection). The septin ring in the neck of a shmoo may act as a barrier to localize mating factors in the shmoo tip.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:16151244
http://purl.org/obo/owl/PMID#PMID_16151244
split septin rings
cellular_component
A pair of rings that flank the site of cell division, formed by splitting of the septin ring (or collar) prior to cytokinesis; this double ring structure is thought to trap proteins needed for cytokinesis or the formation of the new membrane or cell wall between the two septin rings. Split septin rings are known to occur in budding yeast cells and probably occur in other cell types as well.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:16009555
http://purl.org/obo/owl/PMID#PMID_16009555
PMID:16151244
http://purl.org/obo/owl/PMID#PMID_16151244
cellular bud neck split septin rings
cellular_component
Two separate septin rings that are formed from the septin collar at the time of cytokinesis in cells that divide by budding. These two rings are thought to delineate a special compartment in which factors involved in cytokinesis are concentrated.
PMID:16009555
http://purl.org/obo/owl/PMID#PMID_16009555
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
medial membrane band
cellular_component
sterol-rich membrane band
A sterol-rich region of the plasma membrane which forms at the cell surface overlying the contractile ring and spreads into the invaginating plasma membrane surrounding the septum.
PMID:15517003
http://purl.org/obo/owl/PMID#PMID_15517003
germ tube
cellular_component
The slender tubular outgrowth first produced by most spores in germination.
ISBN:0877799148
http://purl.org/obo/owl/ISBN#ISBN_0877799148
Wikipedia:Germ_tube
http://purl.org/obo/owl/Wikipedia#Wikipedia_Germ_tube
post-lysosomal vacuole
cellular_component
A membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis.
PMID:9394012
http://purl.org/obo/owl/PMID#PMID_9394012
PMID:9276759
http://purl.org/obo/owl/PMID#PMID_9276759
GOC:pf
http://purl.org/obo/owl/GOC#GOC_pf
Rpd3S complex
cellular_component
GO:0000509
Clr6 histone deacetylase complex II'
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
Clr6S complex
PMID:19040720
http://purl.org/obo/owl/PMID#PMID_19040720
Rpd3C(S)
A eukaryotically conserved histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species).
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:17450151
http://purl.org/obo/owl/PMID#PMID_17450151
PMID:12773392
http://purl.org/obo/owl/PMID#PMID_12773392
asymmetric synapse
cellular_component
A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density.
GOC:dgh
http://purl.org/obo/owl/GOC#GOC_dgh
GOC:ef
http://purl.org/obo/owl/GOC#GOC_ef
symmetric synapse
cellular_component
A type of synapse occurring primarily on dendrite shafts and neuronal cell bodies. Symmetric synapses involve axons containing clusters of predominantly flattened or elongated vesicles and do not contain a prominent postsynaptic density.
GOC:dgh
http://purl.org/obo/owl/GOC#GOC_dgh
GOC:ef
http://purl.org/obo/owl/GOC#GOC_ef
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
cellular_component
AMPA receptor
An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus.
GOC:ef
http://purl.org/obo/owl/GOC#GOC_ef
AMPA-selective glutamate receptor complex
plastid acetyl-CoA carboxylase complex
cellular_component
plastid ACCase complex
An acetyl-CoA carboxylase complex located in the stroma of a plastid.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
plastid acetate CoA-transferase complex
cellular_component
An acetate CoA-transferase complex located in the stroma of a plastid.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
plastid biotin carboxylase complex
cellular_component
A biotin carboxylase complex located in the stroma of a plastid.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ribonuclease H2 complex
cellular_component
A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p.
PMID:14734815
http://purl.org/obo/owl/PMID#PMID_14734815
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
RNase H2 complex
mismatch repair complex
cellular_component
Any complex formed of proteins that act in mismatch repair.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
MutSalpha complex
cellular_component
A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6.
PMID:11005803
http://purl.org/obo/owl/PMID#PMID_11005803
MMR complex
MSH2/MSH6 complex
MutSbeta complex
cellular_component
MMR complex
A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3.
PMID:11005803
http://purl.org/obo/owl/PMID#PMID_11005803
MSH2/MSH3 complex
angiogenin-PRI complex
cellular_component
A stable heterodimer of angiogenin and placental ribonuclease inhibitor; interaction between angiogenin and PRI prevents angiogenin binding to its receptor to stimulate angiogenesis.
PMID:2706246
http://purl.org/obo/owl/PMID#PMID_2706246
PMID:3470787
http://purl.org/obo/owl/PMID#PMID_3470787
angiogenin-placental ribonuclease inhibitor complex
MutLalpha complex
cellular_component
A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2.
GOC:vk
http://purl.org/obo/owl/GOC#GOC_vk
MLH1/PMS2 complex
MMR complex
MutL-alpha complex
CORUM:292
http://purl.org/obo/owl/CORUM#CORUM_292
MutLbeta complex
cellular_component
A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1.
GOC:vk
http://purl.org/obo/owl/GOC#GOC_vk
MLH1/PMS1 complex
MMR complex
photoreceptor connecting cilium
cellular_component
A nonmotile primary cilium that has a 9+0 microtubule array and forms the portion of the axoneme traversing the boundary between the photoreceptor inner and outer segments.
PMID:15917207
http://purl.org/obo/owl/PMID#PMID_15917207
PMID:8718680
http://purl.org/obo/owl/PMID#PMID_8718680
photoreceptor cilium
MHC class Ib protein complex
cellular_component
A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.
ISBN:0781735149
http://purl.org/obo/owl/ISBN#ISBN_0781735149
PMID:15928678
http://purl.org/obo/owl/PMID#PMID_15928678
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
extrinsic to lysosome membrane
cellular_component
extrinsic to lysosomal membrane
Loosely bound to one surface of the lysosome membrane, but not integrated into the hydrophobic region.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
stereocilium
cellular_component
An actin-based protrusion from the apical surface of auditory and vestibular hair cells. Bundles of stereocilia act as mechanosensory organelles.
PMID:7840137
http://purl.org/obo/owl/PMID#PMID_7840137
PMID:15661519
http://purl.org/obo/owl/PMID#PMID_15661519
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
stereocilium bundle
cellular_component
An actin-based, cross-linked cellular protrusion on the apical surface of auditory and vestibular hair cells. Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes.
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
PMID:15661519
http://purl.org/obo/owl/PMID#PMID_15661519
PMID:7840137
http://purl.org/obo/owl/PMID#PMID_7840137
stereocilia bundle
stereocilium bundle tip
cellular_component
The end of a stereocilium bundle, distal to the site of the bundle's attachment to the apical cell surface.
PMID:17021180
http://purl.org/obo/owl/PMID#PMID_17021180
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
stereocilium tip
actin filament bundle
cellular_component
GO:0000141
GO:0030482
An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
actin cable
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
filopodium tip
cellular_component
The end of a filopodium distal to the body of the cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cuticular plate
cellular_component
A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted.
PMID:12485990
http://purl.org/obo/owl/PMID#PMID_12485990
PMID:8071151
http://purl.org/obo/owl/PMID#PMID_8071151
PMID:2592408
http://purl.org/obo/owl/PMID#PMID_2592408
activin responsive factor complex
Note that this term should not be confused with any of the molecular function and biological process terms that refer to the small GTPase ARF (ADP-ribosylation factor).
cellular_component
A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor.
PMID:12374795
http://purl.org/obo/owl/PMID#PMID_12374795
PMID:9288972
http://purl.org/obo/owl/PMID#PMID_9288972
ARF complex
CBM complex
cellular_component
A protein complex comprising Carma1, Bcl10 and MALT1; plays a role in signal transduction during NF-kappaB activation.
PMID:12909454
http://purl.org/obo/owl/PMID#PMID_12909454
CARMA1-BCL10-Malt1 complex
external side of mitochondrial outer membrane
cellular_component
external side of mitochondrial envelope
The external (cytoplasmic face) of the mitochondrial outer membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cytosolic side of mitochondrial outer membrane
decaprenyl diphosphate synthase complex
cellular_component
A complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:14519123
http://purl.org/obo/owl/PMID#PMID_14519123
homodimeric decaprenyl diphosphate synthase complex
cellular_component
A homodimeric complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis.
PMID:14519123
http://purl.org/obo/owl/PMID#PMID_14519123
heterotetrameric decaprenyl diphosphate synthase complex
cellular_component
A heterotetrameric complex located in the mitochondrial inner membrane that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. In S. pombe it is a heterotetramer of Dlp1 and Dps1.
PMID:14519123
http://purl.org/obo/owl/PMID#PMID_14519123
SOD1-calcineurin complex
cellular_component
A protein complex formed by the association of superoxide dismutase 1 (SOD1) with calcineurin; complex formation is implicated in activation of calcineurin by SOD1.
PMID:17324120
http://purl.org/obo/owl/PMID#PMID_17324120
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cortical endoplasmic reticulum
cellular_component
A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements.
PMID:17686782
http://purl.org/obo/owl/PMID#PMID_17686782
PMID:10931860
http://purl.org/obo/owl/PMID#PMID_10931860
GOC:se
http://purl.org/obo/owl/GOC#GOC_se
peripheral endoplasmic reticulum
peripheral ER
cortical ER
ER-PM peripheral junction
PMID:21062895
http://purl.org/obo/owl/PMID#PMID_21062895
GOC:ans
http://purl.org/obo/owl/GOC#GOC_ans
CURI complex
cellular_component
A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p andIfh1p.
PMID:17452446
http://purl.org/obo/owl/PMID#PMID_17452446
aleurone grain membrane
cellular_component
The lipid bilayer surrounding an aleurone grain.
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
apical lamina of hyaline layer
cellular_component
A fibrous network that is part of the hyalin layer extracellular matrix. The apical lamina is thought to be principally composed of the glycoproteins fibropellins. This matrix has been found in echinoderms.
PMID:9638331
http://purl.org/obo/owl/PMID#PMID_9638331
PMID:7608987
http://purl.org/obo/owl/PMID#PMID_7608987
PMID:2060714
http://purl.org/obo/owl/PMID#PMID_2060714
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
Golgi cisterna membrane
cellular_component
Golgi stack membrane
The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
growth cone membrane
cellular_component
The portion of the plasma membrane surrounding a growth cone.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
multivesicular body membrane
cellular_component
MVE membrane
The lipid bilayer surrounding a multivesicular body.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
MVB membrane
multivesicular endosome membrane
protein storage vacuole membrane
cellular_component
The lipid bilayer surrounding a protein storage vacuole.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ruffle membrane
cellular_component
The portion of the plasma membrane surrounding a ruffle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
membrane ruffle
trans-Golgi network membrane
cellular_component
Golgi trans face membrane
trans Golgi network membrane
The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
neuron projection membrane
cellular_component
The portion of the plasma membrane surrounding a neuron projection.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
dendrite membrane
cellular_component
The portion of the plasma membrane surrounding a dendrite.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
dendritic spine membrane
cellular_component
The portion of the plasma membrane surrounding a dendritic spine.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
integral to mitochondrial membrane
cellular_component
Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of a mitochondrial membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
insulin-responsive compartment
cellular_component
A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2.
PMID:17644329
http://purl.org/obo/owl/PMID#PMID_17644329
GSC
IRC
GLUT4 storage compartment
NHE3/E3KARP/ACTN4 complex
cellular_component
A heterotrimeric protein complex formed by the association of NHE3, E3KARP and alpha-actinin upon an increase in calcium ion concentration; found in clusters localized on plasma membrane and in intracellular compartments.
PMID:11948184
http://purl.org/obo/owl/PMID#PMID_11948184
NHE3/E3KARP/alpha-actinin complex
Piccolo NuA4 histone acetyltransferase complex
cellular_component
A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p.
PMID:15964809
http://purl.org/obo/owl/PMID#PMID_15964809
PMID:12782659
http://purl.org/obo/owl/PMID#PMID_12782659
ELL-EAF complex
cellular_component
A heterodimeric protein complex that acts as an RNA polymerase II elongation factor; the complex is conserved from yeast to humans, and is present in S. pombe, but absent from S. cerevisiae.
PMID:17150956
http://purl.org/obo/owl/PMID#PMID_17150956
SMN complex
Note that a larger complex containing Sm proteins and other subunits is also sometimes referred to as the 'SMN complex'. The larger complex is represented by 'SMN-Sm protein complex ; GO:0034719'.
cellular_component
SMN core complex
survival motor neuron complex
A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus.
PMID:16434402
http://purl.org/obo/owl/PMID#PMID_16434402
PMID:17023415
http://purl.org/obo/owl/PMID#PMID_17023415
Swi5-Sfr1 complex
Note that this term refers to Schizosaccharomyces pombe Swi5, which should not be confused with the unrelated Saccharomyces Swi5p.
cellular_component
Swi5 complex
Sae3-Mei5 complex
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
A conserved DNA recombinase mediator complex that contains two Swi5 monomers and one Sfr1 monomer in Schizosaccharomyces, or orthologs thereof (e.g. Sae3p and Mei5p in Saccharomyces).
PMID:16921379
http://purl.org/obo/owl/PMID#PMID_16921379
PMID:15620352
http://purl.org/obo/owl/PMID#PMID_15620352
carboxy-terminal domain protein kinase complex
cellular_component
A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5.
PMID:16721054
http://purl.org/obo/owl/PMID#PMID_16721054
PMID:17079683
http://purl.org/obo/owl/PMID#PMID_17079683
PMID:15047695
http://purl.org/obo/owl/PMID#PMID_15047695
CTDK complex
DNA ligase IV complex
cellular_component
A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif1p.
PMID:16314503
http://purl.org/obo/owl/PMID#PMID_16314503
DNA ligase IV-XRCC4 complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
neuronal cell body membrane
cellular_component
neuronal cell soma membrane
The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
neuron cell body membrane
cell projection cytoplasm
cellular_component
All of the contents of a cell projection, excluding the plasma membrane surrounding the projection.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
dendrite cytoplasm
cellular_component
All of the contents of a dendrite, excluding the surrounding plasma membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
dendritic cytoplasm
ERMES complex
cellular_component
mitochore
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
Mdm10/Mdm12/Mmm1 complex
ER-mitochondria encounter structure
A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles. The complex is also associated with actively replicating mitochondrial DNA nucleoids, and may further coordinate mitochondrial genome replication and membrane growth.
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
PMID:19556461
http://purl.org/obo/owl/PMID#PMID_19556461
MMM1 complex
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
sarcosine oxidase complex
cellular_component
A complex consisting of 4 protein subunits as a heterotetramer, that possesses sarcosine oxidase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
SREBP-SCAP complex
cellular_component
A protein complex formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP) in the ER membrane; in the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed.
PMID:12923525
http://purl.org/obo/owl/PMID#PMID_12923525
Sre1-Scp1 complex
SREBP-SCAP-Insig complex
cellular_component
A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) the ER membrane.
PMID:12923525
http://purl.org/obo/owl/PMID#PMID_12923525
endosomal scaffold complex
cellular_component
A protein complex that contains MAPKSP1 (MP1, Map2k1ip1) and ROBLD3 (p14, Mapbpip), is anchored to late endosomes, and is involved in selective activation of the ERK1 in ERK/MAPK signaling.
PMID:17496910
http://purl.org/obo/owl/PMID#PMID_17496910
PMID:16227978
http://purl.org/obo/owl/PMID#PMID_16227978
PMID:15263099
http://purl.org/obo/owl/PMID#PMID_15263099
MP1-p14 scaffolding complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
endosomal adaptor complex
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
myosin filament
cellular_component
myosin thick filament
thick filament
A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
kainate selective glutamate receptor complex
cellular_component
An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluR5-7 and KA-1/2 subunits.
URL:http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html
http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html
macromolecular complex
cellular_component
macromolecule complex
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
protein-carbohydrate complex
cellular_component
A macromolecular complex containing both protein and carbohydrate molecules.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
protein-DNA complex
cellular_component
DNA-protein complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A macromolecular complex containing both protein and DNA molecules.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
protein-lipid complex
cellular_component
A macromolecular complex containing both protein and lipid molecules.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Bcl3-Bcl10 complex
cellular_component
A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus.
PMID:16280327
http://purl.org/obo/owl/PMID#PMID_16280327
Fc receptor complex
cellular_component
Fc-receptor complex
FcR complex
immunoglobulin receptor complex
A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
ISBN:0781735149
http://purl.org/obo/owl/ISBN#ISBN_0781735149
Fc-epsilon receptor I complex
cellular_component
IgE receptor complex
A protein complex composed of an Fc-epsilon RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-episilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgE.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
ISBN:0781735149
http://purl.org/obo/owl/ISBN#ISBN_0781735149
immunoglobulin E receptor complex
FceRI complex
Fc-alpha receptor I complex
cellular_component
immunoglobulin A receptor complex
A protein complex composed of an Fc-alpha R alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgA.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
PMID:12524384
http://purl.org/obo/owl/PMID#PMID_12524384
ISBN:0781735149
http://purl.org/obo/owl/ISBN#ISBN_0781735149
IgA receptor complex
FcaRI complex
Fc-gamma receptor I complex
cellular_component
A protein complex composed of an Fc-gamma RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgG.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
ISBN:0781735149
http://purl.org/obo/owl/ISBN#ISBN_0781735149
PMID:11244038
http://purl.org/obo/owl/PMID#PMID_11244038
PMID:12413532
http://purl.org/obo/owl/PMID#PMID_12413532
immunoglobulin G receptor complex
IgG receptor complex
FcgRI complex
Fc-gamma receptor III complex
cellular_component
IgG receptor complex
immunoglobulin G receptor complex
A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG.
PMID:12413532
http://purl.org/obo/owl/PMID#PMID_12413532
PMID:11244038
http://purl.org/obo/owl/PMID#PMID_11244038
ISBN:0781735149
http://purl.org/obo/owl/ISBN#ISBN_0781735149
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
FcgRIII complex
nucleomorph
cellular_component
A small, vestigial nucleus found in some plastids that derive from a eukaryotic endosymbiont. Observed in chlorarachniophytes and cryptomonads, which acquired their plastids from a green and red alga respectively.
PMID:16760254
http://purl.org/obo/owl/PMID#PMID_16760254
Wikipedia:Nucleomorph
http://purl.org/obo/owl/Wikipedia#Wikipedia_Nucleomorph
paranodal junction
cellular_component
A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath.
PMID:14630217
http://purl.org/obo/owl/PMID#PMID_14630217
PMID:11395001
http://purl.org/obo/owl/PMID#PMID_11395001
perinuclear theca
cellular_component
A condensed cytoplasmic structure that covers the nucleus of mammalian spermatozoa except for a narrow zone around the insertion of the tail. It shows two distinct regions, a subacrosomal layer and, continuing caudally beyond the acrosomic system, the postacrosomal sheath. The perinuclear theca has been considered a cytoskeletal scaffold responsible for maintaining the overall architecture of the mature sperm head; however, recent studies indicate that the bulk of its constituent proteins are not traditional cytoskeletal proteins but rather a variety of cytosolic proteins.
PMID:8025156
http://purl.org/obo/owl/PMID#PMID_8025156
PMID:17289678
http://purl.org/obo/owl/PMID#PMID_17289678
porosome
cellular_component
A permanent cup-shaped structure at the cell plasma membrane in secretory cells. Following a secretory stimulus, secretory vesicles transiently dock and fuse at the base of porosomes and release intravesicular contents dictated by the turgor pressure generated from the swelling of secretory vesicles.
PMID:16563225
http://purl.org/obo/owl/PMID#PMID_16563225
PMID:15090256
http://purl.org/obo/owl/PMID#PMID_15090256
Wikipedia:Porosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Porosome
rhoptry membrane
cellular_component
The lipid bilayer surrounding a rhoptry.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
sarcoplasmic reticulum membrane
cellular_component
The lipid bilayer surrounding the sarcoplasmic reticulum.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
sarcoplasmic reticulum lumen
cellular_component
The volume enclosed by the membranes of the sarcoplasmic reticulum.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
DNA recombinase mediator complex
cellular_component
A protein complex that promotes nucleoprotein filament formation during homologous recombination; most known examples contain two or more RecA family proteins (often Rad51 paralogs).
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
GOC:elh
http://purl.org/obo/owl/GOC#GOC_elh
Rhp55-Rhp57 complex
cellular_component
Rad55-Rad57 complex
A conserved heterodimeric DNA recombinase mediator complex that contains the RecA family proteins Rhp55p and Rph57 in Schizosaccharomyces, or orthologs thereof (e.g. Rad55p and Rad57p in Saccharomyces).
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
Rad51B-Rad51C-Rad51D-XRCC2 complex
cellular_component
A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof.
PMID:16093548
http://purl.org/obo/owl/PMID#PMID_16093548
PMID:17114795
http://purl.org/obo/owl/PMID#PMID_17114795
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
BCDX2 complex
XRCC2-RAD51D complex
cellular_component
A heterodimeric DNA recombinase mediator complex that contains the Rad51 paralogs RAD51D and XRCC2, or orthologs thereof; conserved from fission yeast to human but absent from budding yeast.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:16093548
http://purl.org/obo/owl/PMID#PMID_16093548
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
DX2 complex
Rad51C-XRCC3 complex
cellular_component
A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof.
PMID:16093548
http://purl.org/obo/owl/PMID#PMID_16093548
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:17114795
http://purl.org/obo/owl/PMID#PMID_17114795
CX3 complex
Rad51B-Rad51C complex
cellular_component
A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B and RAD51C, or orthologs thereof.
PMID:16093548
http://purl.org/obo/owl/PMID#PMID_16093548
PMID:17114795
http://purl.org/obo/owl/PMID#PMID_17114795
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
BC complex
Weibel-Palade body
cellular_component
A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses.
PMID:11935287
http://purl.org/obo/owl/PMID#PMID_11935287
PMID:16087708
http://purl.org/obo/owl/PMID#PMID_16087708
Wikipedia:Weibel-Palade_body
http://purl.org/obo/owl/Wikipedia#Wikipedia_Weibel-Palade_body
aleurone grain
cellular_component
aleurone body
A membrane-bounded storage granule found in cells of the aleurone layer in plants; contains either a protein matrix, protein-carbohydrate bodies and/or globoids. Aleurone grains are formed by the vacuole, rough endoplasmic reticulum and dictyosomes.
URL:http://www.springerlink.com/content/q7183h5vr7358278/
http://www.springerlink.com/content/q7183h5vr7358278/
URL:http://ejournal.sinica.edu.tw/bbas/content/2004/1/bot451-08.pdf
http://ejournal.sinica.edu.tw/bbas/content/2004/1/bot451-08.pdf
amyloplast envelope
cellular_component
The double lipid bilayer enclosing the amyloplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
amyloplast membrane
cellular_component
Either of the lipid bilayers that surround an amyloplast and form the amyloplast envelope.
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
amyloplast inner membrane
cellular_component
The inner, i.e. lumen-facing, lipid bilayer of the amyloplast envelope; also faces the amyloplast stroma.
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
attachment organelle
cellular_component
A membrane-bounded extension of the cell, originally characterized in Mycoplasma species, that contains an electron-dense core that is part of the cytoskeleton and is oriented lengthwise and ends distally in a bulbous knob (terminal button). Required for adherence to host cells and involved in gliding motility and cell division.
URL:http://authors.library.caltech.edu/3529/
http://authors.library.caltech.edu/3529/
PMID:12003948
http://purl.org/obo/owl/PMID#PMID_12003948
PMID:11325545
http://purl.org/obo/owl/PMID#PMID_11325545
NuA3 histone acetyltransferase complex
cellular_component
A Gcn5-independent multisubunit complex that catalyzes the acetylation of histone H3. The budding yeast complex includes Sas3p, Taf30p, and Yng1p.
PMID:10817755
http://purl.org/obo/owl/PMID#PMID_10817755
PMID:17157260
http://purl.org/obo/owl/PMID#PMID_17157260
cellular bud membrane
cellular_component
cellular bud plasma membrane
The portion of the plasma membrane surrounding a cellular bud.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
acidocalcisome membrane
cellular_component
The lipid bilayer surrounding an acidocalcisome.
PMID:11378195
http://purl.org/obo/owl/PMID#PMID_11378195
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
type VI protein secretion system complex
cellular_component
A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
PMID:16432199
http://purl.org/obo/owl/PMID#PMID_16432199
PMID:16763151
http://purl.org/obo/owl/PMID#PMID_16763151
T6SS complex
chlorosome envelope
Note that the chlorosome envelope is not a single or double lipid bilayer, so this term is not a child of 'organelle membrane ; GO:0031090' or 'organelle envelope ; GO:0031967'.
cellular_component
The structure, composed of a monolayer of glycolipids with embedded proteins, that encloses the pigments and other contents of the chlorosome.
PMID:17303128
http://purl.org/obo/owl/PMID#PMID_17303128
PMID:14729689
http://purl.org/obo/owl/PMID#PMID_14729689
PMID:14507718
http://purl.org/obo/owl/PMID#PMID_14507718
chlorosome membrane
cis-Golgi network membrane
cellular_component
Golgi cis face membrane
The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cis Golgi network membrane
CVT vesicle
cellular_component
A cytosolic vesicle that is enclosed by a double membrane and is implicated in the cytoplasm to vacuole targeting pathway. These vesicles are found in the yeast S. cerevisiae, and contain vacuolar hydrolases, aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p).
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
PMID:15138258
http://purl.org/obo/owl/PMID#PMID_15138258
CVT vesicle membrane
cellular_component
The double lipid bilayer surrounding a CVT vesicle.
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
attachment organelle membrane
cellular_component
The lipid bilayer surrounding an attachment organelle.
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
cyanelle envelope
cellular_component
The double lipid bilayer enclosing the cyanelle and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cyanelle membrane
cellular_component
Either of the lipid bilayers that surround a cyanelle and form the cyanelle envelope.
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
cyanelle thylakoid lumen
cellular_component
The volume enclosed by a cyanelle thylakoid membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cyanelle thylakoid membrane
cellular_component
The lipid bilayer membrane of any thylakoid within a cyanelle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
endoplasmic reticulum-Golgi intermediate compartment membrane
cellular_component
ER-Golgi intermediate compartment membrane
The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.
GOC:pr
http://purl.org/obo/owl/GOC#GOC_pr
PMID:16723730
http://purl.org/obo/owl/PMID#PMID_16723730
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
esterosome
cellular_component
A vesicle filled with crystalline protein that shows sequence similarities with various esterases.
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
PMID:2307702
http://purl.org/obo/owl/PMID#PMID_2307702
esterosome membrane
cellular_component
The lipid bilayer surrounding an esterosome. This membrane has characteristics of rough endoplasmic reticulum (RER) membranes.
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
PMID:2307702
http://purl.org/obo/owl/PMID#PMID_2307702
cytoskeletal calyx
cellular_component
A large cytoskeletal structure located at the posterior end of the perinuclear theca of a mammalian sperm head. The nucleus is tightly associated with the calyx, which contains calicin and basic cylicin proteins.
PMID:9184090
http://purl.org/obo/owl/PMID#PMID_9184090
PMID:12243744
http://purl.org/obo/owl/PMID#PMID_12243744
melanosome membrane
cellular_component
The lipid bilayer surrounding a melanosome.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
microneme membrane
cellular_component
The lipid bilayer surrounding a microneme.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
interphotoreceptor matrix
cellular_component
A specialized extracellularc matrix that surrounds the photoreceptors of the retina and lies between them and the apical surface of the retinal pigment epithelium. The IPM has been implicated in several important activities required for photoreceptor function and maintenance.
URL:http://www.glycoforum.gr.jp/science/hyaluronan/HA17/HA17E.html
http://www.glycoforum.gr.jp/science/hyaluronan/HA17/HA17E.html
PMID:1862095
http://purl.org/obo/owl/PMID#PMID_1862095
PMID:2194288
http://purl.org/obo/owl/PMID#PMID_2194288
hyaline layer
cellular_component
A multilayered extraembryonic matrix that functions as a substrate for cell adhesion through early development. It is thought to protect and lubricate the embryo, stabilize the blastomeres during morphogenesis, and regulate nutrient intake. The major constituent of the hyaline layer is the protein hyalin. This matrix has been found in echinoderms.
PMID:1721506
http://purl.org/obo/owl/PMID#PMID_1721506
PMID:9473317
http://purl.org/obo/owl/PMID#PMID_9473317
URL:http://worms.zoology.wisc.edu/urchins/SUgast_ECM3.html
http://worms.zoology.wisc.edu/urchins/SUgast_ECM3.html
ARC complex
cellular_component
argonaute siRNA chaperone complex
A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA.
PMID:17310250
http://purl.org/obo/owl/PMID#PMID_17310250
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
gas vesicle shell
cellular_component
The proteinaceous structure surrounding a gas vesicle.
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
gas vesicle wall
gas vesicle membrane
chloroplast proton-transporting ATP synthase complex, catalytic core CF(1)
cellular_component
The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the chloroplast thylakoid membrane when the entire ATP synthase is assembled. The chloroplast F0 domain contains three alpha, three beta, one gamma, one delta, and one epsilon subunits.
GOC:pj
http://purl.org/obo/owl/GOC#GOC_pj
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:11032839
http://purl.org/obo/owl/PMID#PMID_11032839
chloroplast proton-transporting F-type ATPase complex, catalytic core CF(1)
chloroplast proton-transporting ATP synthase complex, coupling factor CF(o)
cellular_component
chloroplast proton-transporting ATP synthase complex, coupling factor CF(0)
chloroplast proton-transporting F-type ATPase complex, coupling factor CF(o)
All non-F1 subunits of the chloroplast hydrogen-transporting ATP synthase, including integral and peripheral chloroplast thylakoid membrane proteins.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
proton-transporting V-type ATPase complex
cellular_component
hydrogen-translocating V-type ATPase complex
A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane.
ISBN:0716743663
http://purl.org/obo/owl/ISBN#ISBN_0716743663
PMID:16449553
http://purl.org/obo/owl/PMID#PMID_16449553
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
proton-transporting two-sector ATPase complex, proton-transporting domain
cellular_component
A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins.
PMID:10838056
http://purl.org/obo/owl/PMID#PMID_10838056
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
proton-transporting two-sector ATPase complex, catalytic domain
cellular_component
A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled.
PMID:10838056
http://purl.org/obo/owl/PMID#PMID_10838056
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
proton-transporting V-type ATPase, V0 domain
cellular_component
A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring.
ISBN:0716743663
http://purl.org/obo/owl/ISBN#ISBN_0716743663
PMID:16449553
http://purl.org/obo/owl/PMID#PMID_16449553
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
proton-transporting V-type ATPase, V1 domain
cellular_component
A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0716743663
http://purl.org/obo/owl/ISBN#ISBN_0716743663
PMID:16449553
http://purl.org/obo/owl/PMID#PMID_16449553
plasma membrane proton-transporting V-type ATPase complex
cellular_component
plasma membrane hydrogen ion-transporting ATPase
A proton-transporting two-sector ATPase complex found in the plasma membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
dolichol-phosphate-mannose synthase complex
cellular_component
A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively.
PMID:10835346
http://purl.org/obo/owl/PMID#PMID_10835346
DPM synthase complex
dolichyl-phosphate beta-D-mannosyltransferase complex
CAF-1 complex
cellular_component
A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48.
PMID:17083276
http://purl.org/obo/owl/PMID#PMID_17083276
PMID:17065558
http://purl.org/obo/owl/PMID#PMID_17065558
chromatin assembly factor 1 complex
Lsd1/2 complex
cellular_component
A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast.
PMID:17371846
http://purl.org/obo/owl/PMID#PMID_17371846
PMID:17434129
http://purl.org/obo/owl/PMID#PMID_17434129
PMID:17440621
http://purl.org/obo/owl/PMID#PMID_17440621
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
Swm1/2 complex
PMID:17440621
http://purl.org/obo/owl/PMID#PMID_17440621
SAPHIRE complex
PMID:17371846
http://purl.org/obo/owl/PMID#PMID_17371846
Swm complex
PMID:17440621
http://purl.org/obo/owl/PMID#PMID_17440621
DNA helicase complex
cellular_component
A protein complex that possesses DNA helicase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
DNA helicase A complex
cellular_component
A homohexameric protein complex that possesses DNA helicase activity; associates with DNA polymerase alpha-primase and translocates in the 5' to 3' direction.
PMID:9341218
http://purl.org/obo/owl/PMID#PMID_9341218
vacuolar transporter chaperone complex
cellular_component
VTC complex
A protein complex that contains four related proteins that have been implicated in several membrane-related processes, such as sorting of H+-translocating ATPases, endocytosis, ER-Golgi trafficking, vacuole fusion, vacuolar polyphosphate homeostasis and the microautophagic scission of vesicles into the vacuolar lumen. The complex is enriched at the vacuolar membrane, but also found in other cellular compartments, including the ER and the cell periphery. In Saccharomyces, the subunits are Vtc1p, Vtc2p, Vtc3p and Vtc4p.
PMID:17079729
http://purl.org/obo/owl/PMID#PMID_17079729
PMID:11823419
http://purl.org/obo/owl/PMID#PMID_11823419
SAS acetyltransferase complex
cellular_component
SAS-I complex
A protein complex that possesses histone acetyltransferase activity and links histone acetylation to the assembly of transcriptionally silent chromatin. In vitro, the complex acetylates lysine 16 of histone H4 and lysine 14 of histone H3, although the latter may not be relevant in vivo. The complex contains a catalytic subunit and at least two other subunits; in Saccharomyces, the catalytic subunit is Sas2p and additional subunits are Sas4p and Sas5p.
PMID:11731480
http://purl.org/obo/owl/PMID#PMID_11731480
PMID:15788653
http://purl.org/obo/owl/PMID#PMID_15788653
PMID:12626510
http://purl.org/obo/owl/PMID#PMID_12626510
I-kappaB/NF-kappaB complex
cellular_component
A protein complex containing an inhibitory-kappaB (I-kappaB/IKB) protein and one or more copies of an NF-kappaB protein. In the resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:9407099
http://purl.org/obo/owl/PMID#PMID_9407099
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
Bcl3/NF-kappaB2 complex
cellular_component
Bcl3-NFKB2 complex
Bcl3-p52 complex
A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription.
PMID:9407099
http://purl.org/obo/owl/PMID#PMID_9407099
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
CORVET complex
cellular_component
A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p.
PMID:17488625
http://purl.org/obo/owl/PMID#PMID_17488625
axon part
cellular_component
NIF_Subcellular:sao280355188
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao280355188
A part of an axon, a cell projection of a neuron.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
node of Ranvier
cellular_component
Wikipedia:Nodes_of_Ranvier
http://purl.org/obo/owl/Wikipedia#Wikipedia_Nodes_of_Ranvier
NIF_Subcellular:birnlex_1152_2
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_birnlex_1152_2
An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed.
GOC:mh
http://purl.org/obo/owl/GOC#GOC_mh
internode region of axon
cellular_component
An axon part that is located between the nodes of Ranvier and surrounded by compact myelin sheath.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:mh
http://purl.org/obo/owl/GOC#GOC_mh
internode
NIF_Subcellular:sao206157942
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao206157942
paranode region of axon
cellular_component
An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:mh
http://purl.org/obo/owl/GOC#GOC_mh
NIF_Subcellular:sao234066064
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao234066064
paranode
transcription factor TFTC complex
cellular_component
A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity.
PMID:10373431
http://purl.org/obo/owl/PMID#PMID_10373431
PMID:9603525
http://purl.org/obo/owl/PMID#PMID_9603525
TAT protein transport complex
cellular_component
TAT protein secretion complex
Twin-arginine translocation complex
TAT protein translocation system complex
A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
protein C inhibitor-acrosin complex
cellular_component
A heterodimeric protein complex of protein C inhibitor (SERPINA5) and acrosin; formation of the complex inhibits the protease activity of acrosin.
PMID:11120760
http://purl.org/obo/owl/PMID#PMID_11120760
PMID:7521127
http://purl.org/obo/owl/PMID#PMID_7521127
GOC:pr
http://purl.org/obo/owl/GOC#GOC_pr
SERPINA5-acrosin complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
serpin A5-acrosin complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
PCI-ACR complex
PR:000003652
http://purl.org/obo/owl/PR#PR_000003652
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
PCI-acrosin complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
plasma serine protease inhibitor-acrosin complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
intraconoid microtubule
cellular_component
A microtubule located such that it threads through the conoid and projects through the polar ring.
PMID:11901169
http://purl.org/obo/owl/PMID#PMID_11901169
PMID:16518471
http://purl.org/obo/owl/PMID#PMID_16518471
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
eukaryotic 48S preinitiation complex
cellular_component
GO:0016283
eukaryotic 48S pre-initiation complex
A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA.
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
PMID:15145049
http://purl.org/obo/owl/PMID#PMID_15145049
eukaryotic 48S initiation complex
eukaryotic 80S initiation complex
cellular_component
A protein complex composed of the large and small ribosomal subunits, methionyl-initiatior tRNA, and the capped mRNA. The initiator tRNA is positioned at the ribosomal P site at the AUG codon corresponding to the beginning of the coding region.
PMID:15145049
http://purl.org/obo/owl/PMID#PMID_15145049
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
SBF transcription complex
cellular_component
SBF complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A protein complex that binds to the Swi4/6 cell cycle box (SCB) promoter element, consensus sequence CRCGAAA, and activates transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Swi6p and the activator Swi4p, and is associated with additional proteins known as Whi5p and Msa1p.
PMID:7917338
http://purl.org/obo/owl/PMID#PMID_7917338
PMID:18160399
http://purl.org/obo/owl/PMID#PMID_18160399
PMID:15838511
http://purl.org/obo/owl/PMID#PMID_15838511
PMID:11206552
http://purl.org/obo/owl/PMID#PMID_11206552
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
chromatoid body
cellular_component
A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).
PMID:17183363
http://purl.org/obo/owl/PMID#PMID_17183363
HULC complex
cellular_component
A ubiquitin-conjugating enzyme complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp1, Brl2/Rfp1 and Brl1/Rfp2.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:17374714
http://purl.org/obo/owl/PMID#PMID_17374714
PMID:17363370
http://purl.org/obo/owl/PMID#PMID_17363370
monopolin complex
cellular_component
Pcs1/Mde4 complex
monopolin subcomplex Csm1/Lrs4
A protein complex required for clamping microtubule binding sites, ensuring orientation of sister kinetochores to the same pole (mono-orientation) during meiosis I. In the yeast S. cerevisiae this complex consists of Csm1p, Lrs4p, Hrr25p and Mam1p; in S. pombe Psc1 and Mde4 have been identified as subunits.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:17627824
http://purl.org/obo/owl/PMID#PMID_17627824
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
rDNA heterochromatin
cellular_component
A region of heterochromatin located at the rDNA repeats in a chromosome.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ribosomal DNA heterochromatin
Slx1-Slx4 complex
cellular_component
A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes.
PMID:16467377
http://purl.org/obo/owl/PMID#PMID_16467377
PMID:14528010
http://purl.org/obo/owl/PMID#PMID_14528010
ESCRT-0 complex
cellular_component
A protein complex required for the recycling of Golgi proteins, formation of lumenal membranes and sorting of ubiquitinated proteins into those membranes. This complex includes Vps1p and Hse1p in yeast and the Hrs and STAM proteins in mammals.
PMID:12055639
http://purl.org/obo/owl/PMID#PMID_12055639
PMID:17543868
http://purl.org/obo/owl/PMID#PMID_17543868
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
Hrs/STAM complex
Vps27p-Hse1p complex
high affinity iron permease complex
cellular_component
A protein complex composed of a multicopper ferroxidase that oxidizes Fe(II) to Fe(III), and a ferric iron permease that transports the produced Fe(III) into the cell.
GOC:jp
http://purl.org/obo/owl/GOC#GOC_jp
PMID:8599111
http://purl.org/obo/owl/PMID#PMID_8599111
PMID:16522632
http://purl.org/obo/owl/PMID#PMID_16522632
rhabdomere membrane
cellular_component
The portion of the plasma membrane surrounding the rhabdomere.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Elongator holoenzyme complex
GO:0033589
cellular_component
Elongator core complex
A heterohexameric protein complex that is involved in modification of wobble nucleosides in tRNA, and exerts direct effects on transcriptional elongation and exocytosis. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes.
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:11689709
http://purl.org/obo/owl/PMID#PMID_11689709
PMID:15769872
http://purl.org/obo/owl/PMID#PMID_15769872
PMID:17018299
http://purl.org/obo/owl/PMID#PMID_17018299
GOC:jh
http://purl.org/obo/owl/GOC#GOC_jh
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:18755837
http://purl.org/obo/owl/PMID#PMID_18755837
BRCA2-MAGE-D1 complex
cellular_component
A heterodimeric protein complex formed of BRCA2 and MAGE-D1; may mediate the synergistic activities of the two proteins in regulating cell growth.
PMID:15930293
http://purl.org/obo/owl/PMID#PMID_15930293
TSC1-TSC2 complex
cellular_component
tuberin-hamartin complex
tuberous sclerosis complex
A heterodimeric protein complex consisting of tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
PMID:9580671
http://purl.org/obo/owl/PMID#PMID_9580671
PMID:17121544
http://purl.org/obo/owl/PMID#PMID_17121544
PMID:10585443
http://purl.org/obo/owl/PMID#PMID_10585443
mitotic checkpoint complex
cellular_component
MCC
A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20.
PMID:10704439
http://purl.org/obo/owl/PMID#PMID_10704439
PMID:11726501
http://purl.org/obo/owl/PMID#PMID_11726501
PMID:11535616
http://purl.org/obo/owl/PMID#PMID_11535616
PMID:17650307
http://purl.org/obo/owl/PMID#PMID_17650307
SOD1-Bcl-2 complex
cellular_component
A heterodimeric protein complex formed of superoxide dismutase 1 and Bcl-2. Complex formation is thought to link superoxide dismutase to an apoptotic pathway.
PMID:15233914
http://purl.org/obo/owl/PMID#PMID_15233914
PMID:16790527
http://purl.org/obo/owl/PMID#PMID_16790527
Mei2 nuclear dot
cellular_component
Mei2 dot
A nuclear body that forms during meiotic prophase in a fixed position in the horsetail nucleus; contains Mei2 and meiRNA. May play a role in the progression of meiosis I.
PMID:12808043
http://purl.org/obo/owl/PMID#PMID_12808043
host cell part
cellular_component
Any constituent part of a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
host cell membrane
cellular_component
Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
host cell endomembrane system
cellular_component
A collection of membranous structures involved in transport within the host cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
host intracellular part
cellular_component
Any constituent part of the living contents of a host cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
host cell intracellular part
host intracellular organelle
cellular_component
Organized structure of distinctive morphology and function, occurring within the host cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
host intracellular membrane-bounded organelle
cellular_component
Organized structure of distinctive morphology and function, as found in host cells, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
host intracellular membrane-enclosed organelle
host cell mitochondrion
cellular_component
A semiautonomous, self replicating organelle as found in host cells that occurs in varying numbers, shapes, and sizes in the cell cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
host mitochondria
host cell plastid
cellular_component
Any member of a family of organelles as found in the cytoplasm of host cells, which are membrane-bounded and contain DNA. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
host cell chloroplast
cellular_component
A chlorophyll-containing plastid as found within host cells with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
host cell chloroplast part
cellular_component
host chloroplast component
Any constituent part of a chloroplast as it is found in host cells and which are a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
host cell chloroplast thylakoid membrane
cellular_component
Any sac-like membranous structures (cisternae) in a chloroplast found in host cells, combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
host cell cytoplasm part
cellular_component
Any constituent part of the host cell cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
cytoplasm component
pericanalicular vesicle
cellular_component
A membrane-bounded vesicle found near the apical, or pericanalicular, membrane of a hepatocyte; contains proteins involved in bile salt transport and other fluid and solute transport processes.
PMID:9790571
http://purl.org/obo/owl/PMID#PMID_9790571
PMID:15763347
http://purl.org/obo/owl/PMID#PMID_15763347
Rpd3L complex
cellular_component
GO:0000508
Rpd3C(L)
Clr6L complex
PMID:19040720
http://purl.org/obo/owl/PMID#PMID_19040720
Clr6 histone deacetylase complex I/I'
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
A histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, an Sds-3 family protein, a SIN3 family co-repressor, a WD repeat protein, and a zf- PHD finger (Clr6, Sds3, Pst1, Prw1, Png2 in Schizosaccharomyces pombe; Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p and Ash1p in Saccharomyces cerevisiae).
PMID:17450151
http://purl.org/obo/owl/PMID#PMID_17450151
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
SUMO-targeted ubiquitin ligase complex
cellular_component
A nuclear ubiquitin ligase complex that specifically targets SUMOylated proteins; the complex is formed of homodimers or heterodimers of RNF4 family ubiquitin ligases and is conserved in eukaryotes.
PMID:17762864
http://purl.org/obo/owl/PMID#PMID_17762864
PMID:17762865
http://purl.org/obo/owl/PMID#PMID_17762865
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
basal labyrinth
cellular_component
A region in the lower half of some cells formed from extensive infoldings of the basal plasma membrane; includes cytoplasm adjacent to the infolded membrane.
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
PMID:11640882
http://purl.org/obo/owl/PMID#PMID_11640882
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
acidocalcisome lumen
cellular_component
The volume enclosed by the membranes of an acidocalcisome.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
exomer complex
cellular_component
A protein complex that forms a coat structure on vesicles involved in exocytosis of proteins from the trans-Golgi network to the cell surface; in Saccharomyces, the complex contains Chs5p, Chs6p, and Chs6p paralogues.
PMID:16498409
http://purl.org/obo/owl/PMID#PMID_16498409
PMID:17000877
http://purl.org/obo/owl/PMID#PMID_17000877
pre-autophagosomal structure membrane
cellular_component
A cellular membrane associated with the pre-autophagosomal structure.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:16874040
http://purl.org/obo/owl/PMID#PMID_16874040
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
PMID:17382324
http://purl.org/obo/owl/PMID#PMID_17382324
PAS membrane
phagophore
PMID:20811355
http://purl.org/obo/owl/PMID#PMID_20811355
isolation membrane
cyanelle stroma
cellular_component
The space enclosed by the double membrane of a cyanelle.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
Tor2-Mei2-Ste11 complex
cellular_component
A protein complex that contains the transcription factor Ste11 and the RNA binding protein Mei2; involved in regulation of conjugation in fission yeast.
PMID:17046992
http://purl.org/obo/owl/PMID#PMID_17046992
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
Ric1p-Rgp1p complex
cellular_component
A protein complex that acts as a nucleotide exchange factor for the GTPase Ypt6p, and is required for fusion of endosome-derived vesicles with the Golgi.
GOC:jh
http://purl.org/obo/owl/GOC#GOC_jh
PMID:10990452
http://purl.org/obo/owl/PMID#PMID_10990452
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
polyketide synthase complex
cellular_component
A protein complex that carries out enzymatic reactions involved in the biosynthesis of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:12636085
http://purl.org/obo/owl/PMID#PMID_12636085
PKS
PKS complex
type II polyketide synthase complex
cellular_component
type II polyketide synthase
A polyketide synthase complex that consists of several different polypeptide chains, each of which catalyzes a single reaction.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:12636085
http://purl.org/obo/owl/PMID#PMID_12636085
GOC:cb
http://purl.org/obo/owl/GOC#GOC_cb
type II PKS
type II PKS complex
type III polyketide synthase complex
cellular_component
A polyketide synthase complex that consists of two identical ketosynthase polypeptides.
GOC:cb
http://purl.org/obo/owl/GOC#GOC_cb
PMID:12636085
http://purl.org/obo/owl/PMID#PMID_12636085
type III PKS
type III PKS complex
type III polyketide synthase
Cdc48p-Npl4p-Ufd1p AAA ATPase complex
cellular_component
A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins.
PMID:16179952
http://purl.org/obo/owl/PMID#PMID_16179952
PMID:11813000
http://purl.org/obo/owl/PMID#PMID_11813000
luminal surveillance complex
cellular_component
A multiprotein complex that recognizes ERAD-luminal misfolded substrates and brings them to the ubiquitination/extraction machinery. In yeast, this complex consists of Yos9p, Kar2p and Hrd3p proteins.
PMID:16873065
http://purl.org/obo/owl/PMID#PMID_16873065
enhanceosome
cellular_component
Wikipedia:Enhanceosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Enhanceosome
A protein-DNA complex formed by the association of a distinct set of general and specific transcription factors with a region of enhancer DNA. The cooperative assembly of an enhanceosome confers specificity of transcriptional regulation.
PMID:17574024
http://purl.org/obo/owl/PMID#PMID_17574024
PMID:11250145
http://purl.org/obo/owl/PMID#PMID_11250145
mitochondrial DNA-directed RNA polymerase complex
cellular_component
mitochondrial RNA polymerase holoenzyme complex
mitochondrial RNA polymerase complex
A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:7929382
http://purl.org/obo/owl/PMID#PMID_7929382
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
CVT complex
cellular_component
A protein complex that is involved in the CVT pathway. In budding yeast, the CVT complex consists of multimers of preApe1p.
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
PMID:15659643
http://purl.org/obo/owl/PMID#PMID_15659643
phosphatidylinositol 3-kinase complex I
Note that this term should not be confused with '1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; GO:0005943' or '1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex ; GO:0005944'.
cellular_component
PtdIns-3-kinase complex I
A protein complex that posseses phosphatidylinositol 3-kinase activity and is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Atg14p and Vps15p.
PMID:16421251
http://purl.org/obo/owl/PMID#PMID_16421251
PMID:11157979
http://purl.org/obo/owl/PMID#PMID_11157979
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
phosphatidylinositol 3-kinase complex II
Note that this term should not be confused with '1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; GO:0005943' or '1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex ; GO:0005944'.
cellular_component
PtdIns-3-kinase complex II
A protein complex that posseses phosphatidylinositol 3-kinase activity and is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, VPS38 and Vps15p.
PMID:16421251
http://purl.org/obo/owl/PMID#PMID_16421251
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
PMID:11157979
http://purl.org/obo/owl/PMID#PMID_11157979
Atg1p signaling complex
cellular_component
Atg1p signalling complex
A protein complex that contains a protein kinase and is required for the autophagosome formation. In budding yeast this complex consists of the kinase Atg1p, Atg13p and Atg17p.
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
PMID:15743910
http://purl.org/obo/owl/PMID#PMID_15743910
Atg12-Atg5-Atg16 complex
cellular_component
A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p.
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
PMID:17986448
http://purl.org/obo/owl/PMID#PMID_17986448
photosynthetic membrane
cellular_component
A membrane enriched in complexes formed of reaction centers, accessory pigments and electron carriers, in which photosynthetic reactions take place.
GOC:ds
http://purl.org/obo/owl/GOC#GOC_ds
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
plasma lipoprotein particle
cellular_component
A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
GOC:expert_pt
http://purl.org/obo/owl/GOC#GOC_expert_pt
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
mature chylomicron
cellular_component
A chylomicron that contains apolipoprotein C2 (APOC2), a cofactor for lipoprotein lipase (LPL) activity, and has a mean diameter of 500 nm and density of 0.95g/ml. Mature chylomicron particles transport exogenous (dietary) lipids from the intestines to other body tissues, via the blood and lymph.
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:expert_pt
http://purl.org/obo/owl/GOC#GOC_expert_pt
chylomicron remnant
cellular_component
A lipoprotein particle that is derived from a mature chylomicron particle by the removal of triglycerides from the chylomicron core by lipoprotein lipase and the subsequent loss of surface components. It characteristically contains apolipoprotein E (APOE) and is cleared from the blood by the liver.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
GOC:expert_pt
http://purl.org/obo/owl/GOC#GOC_expert_pt
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
very-low-density lipoprotein particle
cellular_component
VLDL particle
VLDL complex
very-low-density lipoprotein complex
A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:expert_pt
http://purl.org/obo/owl/GOC#GOC_expert_pt
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
low-density lipoprotein particle
cellular_component
LDL complex
LDL particle
A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver.
GOC:expert_pt
http://purl.org/obo/owl/GOC#GOC_expert_pt
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
low-density lipoprotein complex
intermediate-density lipoprotein particle
cellular_component
IDL particle
IDL complex
A triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. IDL particles are found in blood and are formed by the delipidation of very-low-density lipoprotein particles (VLDL). IDL particles are removed from blood by the liver, following binding to the APOE receptor, or are converted to low-density lipoprotein (LDL).
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
GOC:expert_pt
http://purl.org/obo/owl/GOC#GOC_expert_pt
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intermediate-density lipoprotein complex
high-density lipoprotein particle
cellular_component
HDL particle
HDL2
HDL3
high-density lipoprotein class complex
A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
GOC:pde
http://purl.org/obo/owl/GOC#GOC_pde
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:expert_pt
http://purl.org/obo/owl/GOC#GOC_expert_pt
HDL complex
discoidal high-density lipoprotein particle
cellular_component
A newly formed high-density lipoprotein particle; consists of a phospholipid bilayer surrounded by two or more APOA1 molecules. The discoidal HDL particle is formed when lipid-free or lipid-poor APOA1 acquires phospholipids and unesterified cholesterol from either cell membranes or triglyceride-rich lipoproteins (undergoing lipolysis by lipoprotein lipase).
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
GOC:expert_pt
http://purl.org/obo/owl/GOC#GOC_expert_pt
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
discoidal HDL
nascent HDL
nascent high-density lipoprotein particle
spherical high-density lipoprotein particle
cellular_component
A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT).
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
GOC:expert_pt
http://purl.org/obo/owl/GOC#GOC_expert_pt
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
mature high-density lipoprotein particle
mature HDL
spherical HDL
triglyceride-rich lipoprotein particle
cellular_component
A plasma lipoprotein particle that has a hydrophobic core enriched in triglycerides surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Triglyceride-rich lipoproteinparticles transport lipids, which are non-covalently associated with the particles, in the blood.
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
triacylglycerol-rich lipoprotein particle
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Pwp2p-containing subcomplex of 90S preribosome
Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
cellular_component
A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:15231838
http://purl.org/obo/owl/PMID#PMID_15231838
25-30 S subcomplex of 90S preribosome
UTP-B complex
nuclear periphery
cellular_component
The portion of the nuclear lumen proximal to the inner nuclear membrane.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
gerontoplast
cellular_component
A plastid found in senescing, formerly green tissues that is derived from a chloroplast that undergoes an organized developmental program of senescence.
PMID:12654863
http://purl.org/obo/owl/PMID#PMID_12654863
PMID:16151876
http://purl.org/obo/owl/PMID#PMID_16151876
aleurone grain lumen
cellular_component
The volume enclosed by the membrane of an aleurone grain.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
autophagic vacuole lumen
Note that this term should be used for annotating gene products with caution: it should be used only to annotate gene products demonstrated to reside and function normally in the autophagic vacuole lumen, not for molecules that are temporarily found in the lumen prior to degradation.
cellular_component
The volume enclosed within the autophagic vacuole membrane.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
Vps55/Vps68 complex
cellular_component
A membrane-associated protein complex that is required for a late stage of endosomal transport. In budding yeast, this complex consists of Vps55p and Vps68p proteins.
PMID:18216282
http://purl.org/obo/owl/PMID#PMID_18216282
etioplast envelope
cellular_component
The double lipid bilayer enclosing the etioplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
etioplast membrane
cellular_component
Either of the lipid bilayers that surround a etioplast and form the etioplast envelope.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
monolayer-surrounded lipid storage body outer lipid monolayer
cellular_component
lipid droplet outer lipid monolayer
The single layer of phopholipids surrounding a lipid storage body.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
spherosome outer lipid monolayer
oleosome outer lipid monolayer
oil body outer lipid monolayer
lipid storage body surface lipid monolayer
EGO complex
cellular_component
A vacuolar membrane-associated protein complex that is required for activation of microautophagy during exit from rapamycin-induced growth arrest. In budding yeast, S. cerevisiae, this complex includes Meh1p, Gtr2p and Slm4p.
PMID:15989961
http://purl.org/obo/owl/PMID#PMID_15989961
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
GSE complex
cellular_component
GTPase-containing complex for Gap1p sorting in the endosome
A conserved protein complex required for protein sorting from endosome to the plasma membrane. In budding yeast, S. cerevisiae, this complex includes Gtr1p, Gtr2p, Slm4p, Meh1p and Ltv1p and it sorts Gap1p.
PMID:15989961
http://purl.org/obo/owl/PMID#PMID_15989961
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
centriolar satellite
cellular_component
A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
PMID:12403812
http://purl.org/obo/owl/PMID#PMID_12403812
PMID:10579718
http://purl.org/obo/owl/PMID#PMID_10579718
t-UTP complex
Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
cellular_component
Nan1p-containing subcomplex of 90S preribosome
A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p.
PMID:17515605
http://purl.org/obo/owl/PMID#PMID_17515605
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
UTP-C complex
Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
cellular_component
A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p.
PMID:17515605
http://purl.org/obo/owl/PMID#PMID_17515605
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Rrp7p-containing subcomplex of 90S preribosome
Mpp10 complex
Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
cellular_component
A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Mpp10p, Imp3p and Imp4p.
PMID:17515605
http://purl.org/obo/owl/PMID#PMID_17515605
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
BBSome
cellular_component
A protein complex that associates with the primary cilium and is involved in cilium biogenesis; consists of seven conserved proteins: BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9.
PMID:17574030
http://purl.org/obo/owl/PMID#PMID_17574030
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
Bardet-Biedl syndrome complex
chromaffin granule lumen
cellular_component
The volume enclosed by the membrane of a chromaffin granule.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
esterosome lumen
cellular_component
The volume enclosed by the membrane of an esterosome.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
glycosome lumen
cellular_component
The volume enclosed by the membrane of a glycosome.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
Golgi stack lumen
cellular_component
The volume enclosed by any of the membranes of the thin, flattened cisternae that form the central portion of the Golgi complex.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
hydrogenosome lumen
cellular_component
The volume enclosed by the hydrogenosome membrane.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
melanosome lumen
cellular_component
The volume enclosed by the melanosome membrane.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
microneme lumen
cellular_component
The volume enclosed by the microneme membrane.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
protein storage vacuole lumen
cellular_component
The volume enclosed by the protein storage vacuole membrane.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
chromosome, centromeric core region
cellular_component
The innermost portion of the centromeric region of a chromosome, encompassing the core region of a chromosome centromere and the proteins that bind to it.
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
chromosome, centric core region
chromosome, centromeric outer repeat region
cellular_component
chromosome, centric outer repeat region
The portion of the centromeric region of a chromosome that flanks the core region, encompassing repeated regions of a chromosome centromere and the proteins that bind to it.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
proteasome storage granule
cellular_component
PSG
A multisubunit proteasome complex that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state.
PMID:18504300
http://purl.org/obo/owl/PMID#PMID_18504300
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
RNA cap binding complex
cellular_component
Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cytoplasmic RNA cap binding complex
cellular_component
A protein complex found in the cytoplasm that binds the 5' cap structure of an mRNA, and typically consists of the cap-binding protein eIF4E, the adaptor protein eIF4G, and a multi-factor complex comprising eIF1, eIF2, eIF3 and eIF5. This complex mediates recruitment of the 40S subunit to mRNA.
PMID:16405910
http://purl.org/obo/owl/PMID#PMID_16405910
rhoptry lumen
cellular_component
The volume enclosed by the rhoptry membrane.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
PMID:17997128
http://purl.org/obo/owl/PMID#PMID_17997128
synaptic vesicle lumen
cellular_component
The volume enclosed by the synaptic vesicle membrane.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
GCH1 complex
cellular_component
GTP cyclohydrolase I complex
A protein complex that possesses GTP cyclohydrolase I activity. In E. coli and human, the complex is a homodecamer, and monomers are catalytically inactive.
PMID:16696853
http://purl.org/obo/owl/PMID#PMID_16696853
organelle-enclosing lipid monolayer
cellular_component
A lipid monolayer that surrounds and encloses an organelle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GID complex
cellular_component
A protein complex with ubiquitin ligase activity that is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. In S. cerevisiae, the GID (Glucose Induced degradation Deficient) complex consists of Vid30p, Rmd5p, Vid24p, Vid28p, Gid7p, Gid8p, and Fyv10p.
PMID:12686616
http://purl.org/obo/owl/PMID#PMID_12686616
PMID:18508925
http://purl.org/obo/owl/PMID#PMID_18508925
CFTR-NHERF-ezrin complex
cellular_component
A protein complex that contains ezrin, Na+/H+ exchanger regulatory factor (NHERF, also called EBP50), and two copies of the cystic fibrosis transmembrane conductance regulator (CFTR). The CFTR molecules interact with NHERF via their cytoplasmic tail domains; the complex is thought to link the CFTR channel to the actin cytoskeleton and contribute to the regulation of channel activity.
PMID:16129695
http://purl.org/obo/owl/PMID#PMID_16129695
PMID:16798722
http://purl.org/obo/owl/PMID#PMID_16798722
PMID:16926444
http://purl.org/obo/owl/PMID#PMID_16926444
endoplasmic reticulum chaperone complex
cellular_component
ER network complex
endoplasmic reticulum network complex
A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1.
PMID:12475965
http://purl.org/obo/owl/PMID#PMID_12475965
ER chaperone complex
Ig heavy chain-bound endoplasmic reticulum chaperone complex
cellular_component
Ig heavy chain-bound ER chaperone complex
A protein complex that is located in the endoplasmic reticulum (ER) and is formed by the association of an immunoglobulin heavy chain with the proteins of the ER chaperone complex; the latter include BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1.
PMID:12475965
http://purl.org/obo/owl/PMID#PMID_12475965
immunoglobulin heavy chain-bound endoplasmic reticulum chaperone complex
alpha1-beta1 integrin complex
cellular_component
ITGA1-ITGB1 complex
An integrin complex that comprises one alpha1 subunit and one beta1 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
VLA-1 complex
alpha2-beta1 integrin complex
cellular_component
ITGA2-ITGB1 complex
CORUM:2432
http://purl.org/obo/owl/CORUM#CORUM_2432
An integrin complex that comprises one alpha2 subunit and one beta1 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
VLA-2 complex
PMID:3546305
http://purl.org/obo/owl/PMID#PMID_3546305
alpha3-beta1 integrin complex
cellular_component
VLA-3 complex
PMID:3546305
http://purl.org/obo/owl/PMID#PMID_3546305
An integrin complex that comprises one alpha3 subunit and one beta1 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
ITGA3-ITGB1 complex
CORUM:2406
http://purl.org/obo/owl/CORUM#CORUM_2406
alpha4-beta1 integrin complex
cellular_component
VLA-4 complex
An integrin complex that comprises one alpha4 subunit and one beta1 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
ITGA4-ITGB1 complex
alpha4-beta7 integrin complex
cellular_component
ITGA4-ITGB7 complex
An integrin complex that comprises one alpha4 subunit and one beta7 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
inhibin-betaglycan-ActRII complex
cellular_component
A protein complex that consists of inhibin, type III transforming growth factor beta receptor (also known as betaglycan), and the type II activin receptor ActRII. The complex is thought to negatively regulate the activity of activin B.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
PMID:10746731
http://purl.org/obo/owl/PMID#PMID_10746731
alpha5-beta1 integrin complex
cellular_component
ITGA5-ITGB1 complex
VLA-5 complex
An integrin complex that comprises one alpha5 subunit and one beta1 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
alpha6-beta1 integrin complex
cellular_component
An integrin complex that comprises one alpha6 subunit and one beta1 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
ITGA6-ITGB1 complex
CORUM:2413
http://purl.org/obo/owl/CORUM#CORUM_2413
VLA-6 complex
PMID:2649503
http://purl.org/obo/owl/PMID#PMID_2649503
alpha6-beta4 integrin complex
cellular_component
An integrin complex that comprises one alpha6 subunit and one beta1 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
ITGA6-ITGB4 complex
CORUM:2323
http://purl.org/obo/owl/CORUM#CORUM_2323
alpha7-beta1 integrin complex
cellular_component
ITGA7-ITGB1 complex
An integrin complex that comprises one alpha7 subunit and one beta1 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
alpha8-beta1 integrin complex
cellular_component
An integrin complex that comprises one alpha8 subunit and one beta1 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
ITGA8-ITGB1 complex
CORUM:2439
http://purl.org/obo/owl/CORUM#CORUM_2439
alpha9-beta1 integrin complex
cellular_component
ITGA9-ITGB1 complex
An integrin complex that comprises one alpha9 subunit and one beta1 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
alpha10-beta1 integrin complex
cellular_component
ITGA10-ITGB1 complex
CORUM:3057
http://purl.org/obo/owl/CORUM#CORUM_3057
An integrin complex that comprises one alpha10 subunit and one beta1 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
alpha11-beta1 integrin complex
cellular_component
ITGA11-ITGB1 complex
CORUM:3058
http://purl.org/obo/owl/CORUM#CORUM_3058
An integrin complex that comprises one alpha11 subunit and one beta1 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
alphav-beta1 integrin complex
cellular_component
ITGAV-ITGB1 complex
CORUM:2436
http://purl.org/obo/owl/CORUM#CORUM_2436
An integrin complex that comprises one alphav subunit and one beta1 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
alphav-beta3 integrin complex
cellular_component
ITGAV-ITGB3 complex
CORUM:2816
http://purl.org/obo/owl/CORUM#CORUM_2816
An integrin complex that comprises one alphav subunit and one beta3 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
alphav-beta5 integrin complex
cellular_component
An integrin complex that comprises one alphav subunit and one beta5 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
ITGAV-ITGB5 complex
CORUM:2350
http://purl.org/obo/owl/CORUM#CORUM_2350
alphav-beta6 integrin complex
cellular_component
An integrin complex that comprises one alphav subunit and one beta6 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
ITGAV-ITGB6 complex
CORUM:2354
http://purl.org/obo/owl/CORUM#CORUM_2354
alphav-beta8 integrin complex
cellular_component
ITGAV-ITGB8 complex
An integrin complex that comprises one alphav subunit and one beta8 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
alphaL-beta2 integrin complex
cellular_component
Itgal-Itgb2 complex
An integrin complex that comprises one alphaL subunit and one beta2 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
alphaM-beta2 integrin complex
cellular_component
Itgam-Itgb2 complex
An integrin complex that comprises one alphaM subunit and one beta2 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
alphaX-beta2 integrin complex
cellular_component
An integrin complex that comprises one alphaX subunit and one beta2 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
Itgax-Itgb2 complex
alphaD-beta2 integrin complex
cellular_component
An integrin complex that comprises one alphaD subunit and one beta2 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
Itgad-Itgb2 complex
alphaE-beta7 integrin complex
cellular_component
An integrin complex that comprises one alphaE subunit and one beta7 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
Itgae-Itgb7 complex
E.F.G complex
cellular_component
A protein complex that comprises three core spliceosomal proteins, designated E, F, and G. Formation of the E.F.G complex is essential but not sufficient for the formation of a stable U1 snRNP complex.
PMID:8641291
http://purl.org/obo/owl/PMID#PMID_8641291
U11/U12 snRNP
cellular_component
snRNP U11/U12
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
18S U11/U12 snRNP
A ribonucleoprotein complex formed by the association of the U11 and U12 small nuclear ribonucleoproteins.
PMID:15146077
http://purl.org/obo/owl/PMID#PMID_15146077
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ion channel complex
cellular_component
A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
ISBN:071673706X
http://purl.org/obo/owl/ISBN#ISBN_071673706X
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cation channel complex
cellular_component
An ion channel complex through which cations pass.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
calcium channel complex
cellular_component
An ion channel complex through which calcium ions pass.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
potassium channel complex
cellular_component
An ion channel complex through which potassium ions pass.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
sodium channel complex
cellular_component
An ion channel complex through which sodium ions pass.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
chloride channel complex
cellular_component
An ion channel complex through which chloride ions pass.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
methyltransferase complex
cellular_component
A protein complex that possesses methyltransferase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
methylosome
cellular_component
A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains.
PMID:11756452
http://purl.org/obo/owl/PMID#PMID_11756452
PMID:11713266
http://purl.org/obo/owl/PMID#PMID_11713266
20S methyltransferase complex
20S methylosome
pICln-Sm protein complex
cellular_component
6S pICln complex
A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:11713266
http://purl.org/obo/owl/PMID#PMID_11713266
Gemin3-Gemin4-Gemin5 complex
cellular_component
A protein complex that contains Gemin3 (DDX20), Gemin4, and Gemin5, and can bind to snRNAs; may be an intermediate in SMN complex assembly.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:17640873
http://purl.org/obo/owl/PMID#PMID_17640873
Gemin6-Gemin7-unrip complex
cellular_component
A protein complex that contains Gemin6, Gemin7, and unrip (STRAP), and can bind to snRNAs; may play a role in snRNP assembly.
PMID:17640873
http://purl.org/obo/owl/PMID#PMID_17640873
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
SMN-Gemin2 complex
cellular_component
A protein complex that contains the survival motor neuron (SMN) protein and Gemin2; may form the stable core of the larger SMN complex.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:17640873
http://purl.org/obo/owl/PMID#PMID_17640873
SMN-Sm protein complex
Note that this complex is sometimes referred to as the 'SMN complex', but it should not be confused with GO:0032797.
cellular_component
A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm.
PMID:11522829
http://purl.org/obo/owl/PMID#PMID_11522829
PMID:17401408
http://purl.org/obo/owl/PMID#PMID_17401408
SMN-containing protein complex
SmD-containing SMN-Sm protein complex
cellular_component
An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D1, D2, D3, E, F, and G with the SMN complex.
PMID:12975319
http://purl.org/obo/owl/PMID#PMID_12975319
PMID:17401408
http://purl.org/obo/owl/PMID#PMID_17401408
SMN-containing protein complex
Lsm-containing SMN-Sm protein complex
cellular_component
An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D3, E, F, and G, and Lsm10 and Lsm11, with the SMN complex. This complex forms Sm cores on U7 snRNA.
PMID:17401408
http://purl.org/obo/owl/PMID#PMID_17401408
PMID:12975319
http://purl.org/obo/owl/PMID#PMID_12975319
SMN-containing protein complex
transcription factor TFIIIB-alpha complex
cellular_component
A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and a specialized homolog of the conserved subunit BRF referred to as BRFU or TFIIIB50, which found in human but not conserved in yeast; the complex is involved in the regulation of transcription from type 3 (upstream) RNA polymerase III promoters.
PMID:11433012
http://purl.org/obo/owl/PMID#PMID_11433012
transcription factor TFIIIB-beta complex
Note that the subunits of TFIIIB-beta are conserved between human and yeast; however, in yeast a single TFIIIB complex regulates transcription of tRNA, 5S rRNA and U6 snRNA genes, whereas two different TBP-dependent TFIIIB activities exist in humans.
cellular_component
A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and BRF, and is involved in the regulation of transcription from type 2 RNA polymerase III promoters.
PMID:11433012
http://purl.org/obo/owl/PMID#PMID_11433012
transcription factor TFIIIC1 complex
cellular_component
A transcription factor complex that forms part of the TFIIIC complex, observed in human. The complex is poorly characterized, but contains the 250-kDa form of HsBdp1, and is thought to include nuclear factor 1 (NF1). It stimulates binding by human TFIIIC2 and is required for transcription activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:11433012
http://purl.org/obo/owl/PMID#PMID_11433012
PMID:15096501
http://purl.org/obo/owl/PMID#PMID_15096501
transcription factor TFIIIC2 complex
cellular_component
A transcription factor complex that forms part of the TFIIIC complex, observed in human; composed of five subunits (GTF3C1/hTFIIIC220/TFIIICalpha, GTF3C2/hTFIIIC110/TFIIICbeta, GTF3C3/hTFIIIC102/TFIIICgamma, GTF3C4/hTFIIIC90/TFIIICdelta and GTF3C5/hTFIIIC63/TFIIICepsilon in human) that together recognize the type 2 RNA polymerase III promoter.
PMID:11433012
http://purl.org/obo/owl/PMID#PMID_11433012
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
TFIIIC-TOP1-SUB1 complex
cellular_component
TFIIIC-Topoisomerase 1-PC4 complex
A protein complex that contains TFIIIC, topoisomerase 1, and Sub1/PC4. Characterized in human, the complex is involved in regulating transcription from RNA polymerase III (Pol III) promoters. Topoisomerase 1 and Sub1 enhance the accuracy of transcription termination, and promote reinitiation by Pol III.
PMID:9660958
http://purl.org/obo/owl/PMID#PMID_9660958
APC-tubulin-IQGAP1 complex
Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
cellular_component
60S APC complex
A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), alpha-tubulin, gamma-tubulin, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization.
PMID:17126424
http://purl.org/obo/owl/PMID#PMID_17126424
APC-Axin-1-beta-catenin complex
Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
cellular_component
A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), Axin-1, and beta-catenin.
PMID:16188939
http://purl.org/obo/owl/PMID#PMID_16188939
23S APC complex
APC-IQGAP complex
Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
cellular_component
A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC) and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration.
PMID:15572129
http://purl.org/obo/owl/PMID#PMID_15572129
APC-IQGAP1-Cdc42 complex
Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
cellular_component
A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration.
PMID:15572129
http://purl.org/obo/owl/PMID#PMID_15572129
APC-IQGAP1-Rac1 complex
Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
cellular_component
A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Rac1, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration.
PMID:15572129
http://purl.org/obo/owl/PMID#PMID_15572129
APC-IQGAP1-CLIP-170 complex
Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
cellular_component
A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and CLIP-170; may play a role in cytoskeleton organization and cell migration.
PMID:15572129
http://purl.org/obo/owl/PMID#PMID_15572129
Axin-APC-beta-catenin-GSK3B complex
Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
cellular_component
A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), Axin-1, beta-catenin, and glycogen synthase kinase 3 beta. Formation of this complex leads to phosphorylation of beta-catenin and down-regulation of beta-catenin activity.
PMID:9601641
http://purl.org/obo/owl/PMID#PMID_9601641
Par3-APC-KIF3A complex
Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
cellular_component
A protein complex that contains Par3, the tumor suppressor protein adenomatous polyposis coli (APC), and the kinesin-related protein KIF3A; involved in establishing neuronal cell polarity.
PMID:15556865
http://purl.org/obo/owl/PMID#PMID_15556865
Scrib-APC complex
Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
cellular_component
hScrib-APC complex
A protein complex that contains the Scribble protein (a cell polarity determinant) and the tumor suppressor protein adenomatous polyposis coli (APC); may be involved in the control of cell proliferation.
PMID:16611247
http://purl.org/obo/owl/PMID#PMID_16611247
Scrib-APC-beta-catenin complex
Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
cellular_component
A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation.
PMID:16611247
http://purl.org/obo/owl/PMID#PMID_16611247
hScrib-APC-beta-catenin complex
aryl hydrocarbon receptor complex
cellular_component
AHRC
AhR complex
A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:7598497
http://purl.org/obo/owl/PMID#PMID_7598497
cytosolic aryl hydrocarbon receptor complex
cellular_component
cytosolic AHRC
9S-cytosolic aryl hydrocarbon (Ah) receptor non-ligand activated complex
cytosolic AhR complex
An aryl hydrocarbon receptor complex found in the cytosol, in which the ligand-binding subunit AhR is not bound to ligand; consists of AhR, two molecules of HSP90, the protein kinase c-Src, and the immunophilin XAP2/AIP.
PMID:7598497
http://purl.org/obo/owl/PMID#PMID_7598497
PMID:8937476
http://purl.org/obo/owl/PMID#PMID_8937476
PMID:9447995
http://purl.org/obo/owl/PMID#PMID_9447995
nuclear aryl hydrocarbon receptor complex
cellular_component
nuclear AhR complex
An aryl hydrocarbon receptor (AhR) complex found in the nucleus; ; consists of ligand-bound AhR and the aryl hydrocarbon receptor nuclear translocator (ARNT).
PMID:7598497
http://purl.org/obo/owl/PMID#PMID_7598497
nuclear AHRC
6S-nuclear aryl hydrocarbon (Ah) receptor ligand-activated complex
secretory granule lumen
cellular_component
The volume enclosed by the membrane of a secretory granule.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
recycling endosome lumen
cellular_component
The volume enclosed by the membranes of a recycling endosome.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
Set3 complex
cellular_component
A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p.
GOC:ds
http://purl.org/obo/owl/GOC#GOC_ds
PMID:11711434
http://purl.org/obo/owl/PMID#PMID_11711434
HDAC3 complex
SET3C
Sid2-Mob1 complex
cellular_component
Sid2-Mob1 kinase complex
Dbf2p-Mob1p complex
A protein complex that contains a protein kinase (Sid2 in S. pombe) and its regulatory subunit (Mob1). The Sid2p-Mob1p kinase complex is a component of the septation initiation network in fission yeast (called the mitotic exit network in S. cerevisiae) and is required for cytokinesis. The analogous complex in S. cerevisiae is called Dbf2p-Mob1p complex.
PMID:10837231
http://purl.org/obo/owl/PMID#PMID_10837231
PMID:15060149
http://purl.org/obo/owl/PMID#PMID_15060149
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
Sid2p-Mob1p complex
Swi5-Swi2 complex
Note that this term refers to Schizosaccharomyces pombe Swi5 and Swi2, which should not be confused with the unrelated Saccharomyces Swi5p and Swi2p.
cellular_component
Swi5 complex
A protein complex involved that contains proteins known in Schizosaccharomyces as Swi5 monomers and Swi2, and is involved in mating type switching.
PMID:14663140
http://purl.org/obo/owl/PMID#PMID_14663140
ABIN2-NFKB1-MAP3K8 complex
cellular_component
ABIN2-NFKB1-TPL-1 complex
A protein complex that contains the precursor form of NF-kappaB (p105), the NF-kappaB inhibitor ABIN-2, and the kinase TPL-2 (MAP3K8); the complex stabilizes TPL-2 and is involved in signaling in lipopolysaccharide (LPS)-stimulated macrophages.
PMID:15169888
http://purl.org/obo/owl/PMID#PMID_15169888
PDX1-PBX1b-MRG1 complex
cellular_component
acinar cell-specific C complex
A protein complex that contains the homeodomain proteins PDX1, PBX1b and MRG1 (MEIS2) and is involved in the transcriptional regulation of pancreatic acinar cell-specific genes.
PMID:9710595
http://purl.org/obo/owl/PMID#PMID_9710595
PMID:11279116
http://purl.org/obo/owl/PMID#PMID_11279116
FHL2-CREB complex
cellular_component
A protein complex that contains CREB and FHL2, and is involved in transcriptional regulation.
PMID:11046156
http://purl.org/obo/owl/PMID#PMID_11046156
FHL3-CREB complex
cellular_component
A protein complex that contains CREB and FHL3, and is involved in transcriptional regulation.
PMID:11046156
http://purl.org/obo/owl/PMID#PMID_11046156
Ecsit-NDUFAF1 complex
cellular_component
Any large protein complex that contains Ecsit and NDUFAF1, is located in the mitochondrion, and is involved in the assembly of complex I of the oxidative phosphorylation system. In mammalian cells, three complexes of approximately 500, 600, and 850 kDa containing the 45 kDa isoform of Ecsit and NDUFAF1 have been observed.
PMID:17344420
http://purl.org/obo/owl/PMID#PMID_17344420
nuclear mitotic cohesin complex
Note that this term should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i. e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used.
cellular_component
A cohesin complex that mediates sister chromatid cohesion in the nucleus during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
nuclear meiotic cohesin complex
Note that this term should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i. e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used.
cellular_component
A cohesin complex that mediates sister chromatid cohesion in the nucleus during meiosis; has a subunit composition distinct from that of the meiotic cohesin complex.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
microtubule organizing center attachment site
Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'.
cellular_component
MTOC attachment site
microtubule organising centre attachment site
MAS
A region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches; protein complexes embedded in the nuclear envelope mediate direct or indirect linkages between the microtubule cytoskeleton and the nuclear envelope.
PMID:18692466
http://purl.org/obo/owl/PMID#PMID_18692466
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
SUN-KASH complex
cellular_component
A protein complex that spans the nuclear outer and inner membranes, thereby linking the major cytoplasmic cytoskeleton elements to the nuclear lumen; the complex is conserved in eukaryotes and contains proteins with SUN and KASH domains.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:18692466
http://purl.org/obo/owl/PMID#PMID_18692466
SC5b-7 complex
cellular_component
A protein complex that consist of complement components C5b6 and C7 stably inserted in a cell membrane. Formation of the SC5b-7 complex is the first phase of membrane attack complex assembly.
PMID:10090939
http://purl.org/obo/owl/PMID#PMID_10090939
RasGAP-Fyn-Lyn-Yes complex
Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
cellular_component
p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated
A protein complex that consists of a GTPase activator protein (GAP) for Ras and three Src family protein tyrosine kinases, Fyn, Lyn and Yes. The complex is involved in signaling upon platelet activation.
PMID:1544885
http://purl.org/obo/owl/PMID#PMID_1544885
alphav-beta5 integrin-vitronectin complex
cellular_component
ITGAV-ITGB5-VTN complex
CORUM:3117
http://purl.org/obo/owl/CORUM#CORUM_3117
A protein complex that comprises one integrin alphav subunit, one integrin beta5 subunit, and vitronectin.
PMID:1694173
http://purl.org/obo/owl/PMID#PMID_1694173
Reactome:REACT_14045.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_14045.1
oligosaccharyltransferase I complex
cellular_component
OSTCI
An oligosaccharyltransferase (OST) complex that contains at least seven polypeptides and is the major OST complex in mammalian cells. Of the three forms of mammalian OST complex identified, the OSTI complex has the weakest affinity for ribosomes.
PMID:15835887
http://purl.org/obo/owl/PMID#PMID_15835887
oligosaccharyltransferase II complex
cellular_component
OSTCII
An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma. Of the three forms of mammalian OST complexes identified, the OSTII complex has intermediate affinity for ribosomes.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
PMID:15835887
http://purl.org/obo/owl/PMID#PMID_15835887
oligosaccharyltransferase III complex
cellular_component
OSTCIII
An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma and the tetrameric TRAP complex. Of the three forms of mammalian OST complexes identified, the OSTIII complex has the strongest affinity for ribosomes.
PMID:15835887
http://purl.org/obo/owl/PMID#PMID_15835887
subapical complex
cellular_component
SAC
The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells.
PMID:11752566
http://purl.org/obo/owl/PMID#PMID_11752566
PMID:12500938
http://purl.org/obo/owl/PMID#PMID_12500938
polytene chromosome, telomeric region
cellular_component
The terminal region of a polytene chromosome.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
phosphatidylinositol 3-kinase complex, class III
cellular_component
phosphoinositide 3-kinase complex, class III
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
A complex containing a heterodimer of a catalytic Class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI).
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
PMID:9255069
http://purl.org/obo/owl/PMID#PMID_9255069
class III PI3K complex
RCAF complex
cellular_component
A protein complex that facilitates the assembly of nucleosomes on to newly synthesized DNA. In Drosophila, the complex comprises ASF1 and histones H3 and H4.
PMID:10591219
http://purl.org/obo/owl/PMID#PMID_10591219
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
replication-coupling assembly factor complex
brahma complex
cellular_component
BRM complex
A SWI/SNF-type complex that contains the ATPase product of the Drosophila brahma gene, or an ortholog thereof.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
PMID:12482982
http://purl.org/obo/owl/PMID#PMID_12482982
PMID:10809665
http://purl.org/obo/owl/PMID#PMID_10809665
interchromatin granule
cellular_component
A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs).
PMID:10984439
http://purl.org/obo/owl/PMID#PMID_10984439
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
NIF_Subcellular:sao1049471211
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1049471211
ICG
omega speckle
cellular_component
A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs).
PMID:10984439
http://purl.org/obo/owl/PMID#PMID_10984439
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
micro-ribonucleoprotein complex
cellular_component
A complex containing both protein and micro-RNA (miRNA) molecules. miRNAs are approximately 22 nucleotide noncoding RNAs derived from endogenous genes; they are processed from the stem of a longer hairpin like structure termed a pre-miRNA.
PMID:14559182
http://purl.org/obo/owl/PMID#PMID_14559182
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
miRNP complex
cilium axoneme
cellular_component
The bundle of microtubules and associated proteins that forms the core of cilia in eukaryotic cells and is responsible for their movements.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
flagellar axoneme
cellular_component
flagellum axoneme
The bundle of microtubules and associated proteins that forms the core of flagellar in eukaryotic cells and is responsible for their movements.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
histone methyltransferase complex
cellular_component
A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
ESC/E(Z) complex
cellular_component
PRC2 complex
PMID:20064375
http://purl.org/obo/owl/PMID#PMID_20064375
GOC:sp
http://purl.org/obo/owl/GOC#GOC_sp
Extra Sex Combs/Enhancer of Zeste complex
A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
PMID:12408864
http://purl.org/obo/owl/PMID#PMID_12408864
PMID:20064375
http://purl.org/obo/owl/PMID#PMID_20064375
GOC:sp
http://purl.org/obo/owl/GOC#GOC_sp
PMID:12408863
http://purl.org/obo/owl/PMID#PMID_12408863
FACT complex
cellular_component
Facilitates chromatin transcription complex
An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer.
GOC:expert_tf
http://purl.org/obo/owl/GOC#GOC_expert_tf
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:12934006
http://purl.org/obo/owl/PMID#PMID_12934006
PMID:12934007
http://purl.org/obo/owl/PMID#PMID_12934007
PMID:16678108
http://purl.org/obo/owl/PMID#PMID_16678108
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
GOC:expert_ras
http://purl.org/obo/owl/GOC#GOC_expert_ras
GOC:expert_ks
http://purl.org/obo/owl/GOC#GOC_expert_ks
PRC1 complex
cellular_component
Polycomb repressive complex 1
An insect multiprotein complex containing the products of many of the Polycomb Group genes including Polycomb, Posterior sex combs, polyhomeotic and Sex comb on midleg. The Polycomb Group proteins are required for stable long-term maintenance of transcriptionally repressed states and the PRC1 complex directly antagonizes ATP-dependent remodeling of nucleosomal arrays.
PMID:10412979
http://purl.org/obo/owl/PMID#PMID_10412979
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
exon-exon junction complex
cellular_component
A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.
PMID:11743026
http://purl.org/obo/owl/PMID#PMID_11743026
PMID:11532962
http://purl.org/obo/owl/PMID#PMID_11532962
EJC
female germline ring canal outer rim
See also the fly_anatomy.ontology term 'outer nurse cell ring canal rim ; FBbt:00004882'.
cellular_component
germline ring canal outer rim
ovarian ring canal outer rim
nurse cell ring canal outer rim
An electron opaque backbone of the insect ovarian ring canal that is a part of or adjacent to the plasma membrane. The outer rim is established as the cleavage furrow is arrested, and contains F-actin, anillin, glycoproteins and at least one a protein with a high content of phosphorylated tyrosine residues.
PMID:7925006
http://purl.org/obo/owl/PMID#PMID_7925006
PMID:12435357
http://purl.org/obo/owl/PMID#PMID_12435357
female germline ring canal inner rim
See also the fly_anatomy.ontology term 'inner nurse cell ring canal rim ; FBbt:00004881'.
cellular_component
germline ring canal inner rim
nurse cell ring canal inner rim
ovarian ring canal inner rim
A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins.
PMID:10556087
http://purl.org/obo/owl/PMID#PMID_10556087
PMID:7925006
http://purl.org/obo/owl/PMID#PMID_7925006
PMID:9093858
http://purl.org/obo/owl/PMID#PMID_9093858
Rb-E2F complex
cellular_component
A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression.
PMID:14616073
http://purl.org/obo/owl/PMID#PMID_14616073
retinoblastoma-E2F complex
cytoneme
cellular_component
membrane nanotube
Wikipedia:Membrane_nanotube
http://purl.org/obo/owl/Wikipedia#Wikipedia_Membrane_nanotube
Wikipedia:Membrane_nanotube
http://purl.org/obo/owl/Wikipedia#Wikipedia_Membrane_nanotube
A long, thin, polarized cell projection that contains actin and can extend for distances many times the diameter of the cell. Cytonemes represent extensions of cell cytoplasm and typically have a diameter of approximately 0.2um.
PMID:10367889
http://purl.org/obo/owl/PMID#PMID_10367889
PMID:10675901
http://purl.org/obo/owl/PMID#PMID_10675901
ciliary rootlet
cellular_component
A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm.
PMID:12427867
http://purl.org/obo/owl/PMID#PMID_12427867
NuA4 histone acetyltransferase complex
cellular_component
TIP60 histone acetyltransferase complex
TIP60 histone acetylase complex
A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
PMID:10966108
http://purl.org/obo/owl/PMID#PMID_10966108
PMID:14966270
http://purl.org/obo/owl/PMID#PMID_14966270
Hedgehog signaling complex
cellular_component
Hedgehog signalling complex
A multiprotein complex that binds microtubules in a Hedgehog-dependent manner, and is required for signal transduction by members of the Hedgehog family of proteins. The core components of the complex are the serine/threonine protein kinase Fused, the kinesin motor protein Costal2 (Cos2), and a zinc finger transcription factor (Gli family members in humans, and Cubitus interruptus (Ci) in Drosophila).
PMID:10825151
http://purl.org/obo/owl/PMID#PMID_10825151
PMID:15057936
http://purl.org/obo/owl/PMID#PMID_15057936
HSC
male germline ring canal
cellular_component
testicular ring canal
An intercellular bridge that connects the germline cells of a male cyst.
PMID:9635420
http://purl.org/obo/owl/PMID#PMID_9635420
spermatocyte ring canal
female germline ring canal
cellular_component
nurse cell ring canal
ovarian ring canal
An intercellular bridge that connects the germline cells of a female cyst.
PMID:9635420
http://purl.org/obo/owl/PMID#PMID_9635420
transcriptionally active chromatin
cellular_component
The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed.
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
PMID:17965872
http://purl.org/obo/owl/PMID#PMID_17965872
transcriptionally silent chromatin
cellular_component
transcriptionally inactive chromatin
The ordered and organized complex of DNA and protein that forms regions of the chromosome that are not being actively transcribed.
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
PMID:17965872
http://purl.org/obo/owl/PMID#PMID_17965872
SPOTS complex
cellular_component
A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis.
PMID:20182505
http://purl.org/obo/owl/PMID#PMID_20182505
serine palmitoyltransferase, Orm1/2, Tsc3 and Sac1 complex
Toll-like receptor 1-Toll-like receptor 2 protein complex
GO:0038125
cellular_component
TLR2:TLR1 heterodimer
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
toll-like receptor TLR1:TLR2 heterodimeric complex
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
A heterodimeric protein complex containing Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2).
PMID:21481769
http://purl.org/obo/owl/PMID#PMID_21481769
GOC:signaling
http://purl.org/obo/owl/GOC#GOC_signaling
PMID:17889651
http://purl.org/obo/owl/PMID#PMID_17889651
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
TLR1:TLR2 complex
Reactome:REACT_8486.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_8486.1
TLR1-TLR2 protein complex
Toll-like receptor 2-Toll-like receptor 6 protein complex
GO:0038126
cellular_component
toll-like receptor TLR6:TLR2 heterodimeric complex
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
Reactome:REACT_8554.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_8554.1
TLR2:TLR6 heterodimer
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
TLR2-TLR6 protein complex
TLR6:TLR2 complex
A heterodimeric protein complex containing Toll-like receptor 2 (TLR2) and Toll-like receptor 6 (TLR6).
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
PMID:19931471
http://purl.org/obo/owl/PMID#PMID_19931471
GOC:signaling
http://purl.org/obo/owl/GOC#GOC_signaling
PMID:21481769
http://purl.org/obo/owl/PMID#PMID_21481769
Cul8-RING ubiquitin ligase complex
cellular_component
A ubiquitin ligase complex in which a cullin from the Cul8 subfamily and a RING domain protein form the catalytic core. In S. cerevisiae, Mms1p acts as the adaptor protein and substrate specificity is conferred by any of a number of different proteins.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:20139071
http://purl.org/obo/owl/PMID#PMID_20139071
histone locus body
cellular_component
A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body.
PMID:16533947
http://purl.org/obo/owl/PMID#PMID_16533947
PMID:18927579
http://purl.org/obo/owl/PMID#PMID_18927579
PMID:19620235
http://purl.org/obo/owl/PMID#PMID_19620235
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
HLB
PMID:16533947
http://purl.org/obo/owl/PMID#PMID_16533947
PMID:19620235
http://purl.org/obo/owl/PMID#PMID_19620235
PMID:18927579
http://purl.org/obo/owl/PMID#PMID_18927579
pre-B cell receptor complex
Despite its name, the pre-BCR is not a receptor complex, as it appears to provide a low level of signal not dependent on a ligand, but rather simply on correct assembly of the complex as a measure for correct Ig heavy chain recombination and folding. A significant proportion of pre-BCR complexes fail to reach the cell surface, and in some cases may provide their signaling function from the trans-Golgi network or lysosome.
cellular_component
An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
PMID:17306522
http://purl.org/obo/owl/PMID#PMID_17306522
PMID:16464608
http://purl.org/obo/owl/PMID#PMID_16464608
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
pre-BCR
UBC13-UEV1A complex
cellular_component
A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains and is involved in NF-kappaB activation. In humans at least, the complex comprises the ubiquitin-conjugating enzyme UBC13 and ubiquitin-conjugating enzyme variant 1A (UEV1A).
GOC:amm
http://purl.org/obo/owl/GOC#GOC_amm
PMID:16129784
http://purl.org/obo/owl/PMID#PMID_16129784
microtubule plus end
cellular_component
growing microtubule plus end
microtubule plus-end
The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
GOC:lb
http://purl.org/obo/owl/GOC#GOC_lb
PMID:12700769
http://purl.org/obo/owl/PMID#PMID_12700769
PMID:16643273
http://purl.org/obo/owl/PMID#PMID_16643273
extrinsic to thylakoid membrane
cellular_component
Loosely bound to one surface of a thylakoid membrane, but not integrated into the hydrophobic region.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
peripheral to thylakoid membrane
extrinsic to plastid thylakoid membrane
cellular_component
Loosely bound to one surface of a plastid thylakoid membrane, but not integrated into the hydrophobic region.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
peripheral to plastid thylakoid membrane
extrinsic to lumenal side of plastid thylakoid membrane
cellular_component
peripheral to lumenal side of plastid thylakoid membrane
Loosely bound to the surface of a plastid thylakoid membrane that faces the lumen but not integrated into the hydrophobic region.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
extrinsic to stromal side of plastid thylakoid membrane
cellular_component
peripheral to stromal side of plastid thylakoid membrane
Loosely bound to the surface of a plastid thylakoid membrane that faces the stroma but not integrated into the hydrophobic region.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
extrinsic to plastid membrane
cellular_component
peripheral to plastid membrane
Loosely bound to one surface of a plastid membrane, but not integrated into the hydrophobic region.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
extrinsic to plastid inner membrane
cellular_component
peripheral to plastid inner membrane
Loosely bound to one surface of a plastid inner membrane, but not integrated into the hydrophobic region.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
extrinsic to stromal side of plastid inner membrane
cellular_component
Loosely bound to the surface of a plastid inner membrane that faces the stroma, but not integrated into the hydrophobic region.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
peripheral to stromal side of plastid inner membrane
PR-DUB complex
cellular_component
A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively.
PMID:20436459
http://purl.org/obo/owl/PMID#PMID_20436459
Polycomb repressive deubiquitinase complex
PMID:20436459
http://purl.org/obo/owl/PMID#PMID_20436459
NF-kappaB p50/p65 complex
Note that the p50 subunit is encoded by NFKB1 gene in human and the p65 subunit is encoded by the RELA gene in human. Similar nomenclature is used in other vertebrate species. The p50 subunit has a precursor form p105 in some publications.
cellular_component
NF-kappa p105/p65 complex
PMID:9299584
http://purl.org/obo/owl/PMID#PMID_9299584
NF-kappa p105/RelA complex
PMID:9299584
http://purl.org/obo/owl/PMID#PMID_9299584
NF-kappa p50/RelA complex
PMID:9299584
http://purl.org/obo/owl/PMID#PMID_9299584
A heterodimer of NF-kappa B p50 and p65 subunits.
GO:add
http://purl.org/obo/owl/GO#GO_add
PMID:20393192
http://purl.org/obo/owl/PMID#PMID_20393192
PMID:9299584
http://purl.org/obo/owl/PMID#PMID_9299584
NF-kappa B1/RelA complex
PMID:9299584
http://purl.org/obo/owl/PMID#PMID_9299584
NF-kappa B1/p65 complex
PMID:9299584
http://purl.org/obo/owl/PMID#PMID_9299584
urease complex
Eukaryotic microorganisms, plants, and probably Gram-positive bacteria, possess a homopolymeric urease. In contrast, urease complexes from gram-negative bacteria studied thus far clearly possess three distinct subunits (alpha, beta and gamma). Tightly bound nickel is present in all urease complexes.
cellular_component
A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide).
PMID:2651866
http://purl.org/obo/owl/PMID#PMID_2651866
InterPro:IPR008221
http://purl.org/obo/owl/InterPro#InterPro_IPR008221
azurophil granule membrane
cellular_component
The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
PMID:17152095
http://purl.org/obo/owl/PMID#PMID_17152095
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
primary granule membrane
azurophil granule lumen
cellular_component
The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
PMID:17152095
http://purl.org/obo/owl/PMID#PMID_17152095
primary granule lumen
specific granule membrane
cellular_component
The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
PMID:7334549
http://purl.org/obo/owl/PMID#PMID_7334549
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
secondary granule membrane
specific granule lumen
cellular_component
secondary granule lumen
The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
PMID:7334549
http://purl.org/obo/owl/PMID#PMID_7334549
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
root hair
This term is a child of 'cell projection' and not 'cell hair' to distinguish it from animal cell hairs, which are morphologically distinct.
cellular_component
A long, thin projection from a root epidermal cell that contains F-actin and tubulin, and a cell wall.
PO:0000256
http://purl.org/obo/owl/PO#PO_0000256
URL:http://www.jstor.org/stable/4354264
http://www.jstor.org/stable/4354264
root hair tip
cellular_component
The tip portion of an outgrowth of a root epidermal cell.
PO:0000029
http://purl.org/obo/owl/PO#PO_0000029
root hair cell tip
CD40 receptor complex
cellular_component
A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
PMID:9221764
http://purl.org/obo/owl/PMID#PMID_9221764
PMID:20614026
http://purl.org/obo/owl/PMID#PMID_20614026
mitochondrial prohibitin complex
cellular_component
A complex composed of two proteins, prohibitin 1 and prohibitin 2 (PHB1/PHB-1 and PHB2/PHB-2) that is highly conserved amongst eukaryotes and associated with the inner mitochondrial membrane. The mitochondrial prohibitin complex is a macromolecular supercomplex composed of repeating heterodimeric subunits of PHB1 and PHB2. The mitochondrial prohibitin complex plays a role in a number of biological processes, including mitochondrial biogenesis and function, development, replicative senescence, and cell death.
PMID:21164222
http://purl.org/obo/owl/PMID#PMID_21164222
PMID:12237468
http://purl.org/obo/owl/PMID#PMID_12237468
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
mitochondrial inner membrane prohibitin complex
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
Nrd1 complex
cellular_component
A complex that functions in transcription termination of RNA polymerase II transcribed non-coding RNAs. This complex interacts with the carboxy-terminal domain (CTD) of PolII and the terminator sequences in the nascent RNA transcript. In yeast this complex consists of Nrd1p, Nab3p, and Sen1p.
PMID:21084293
http://purl.org/obo/owl/PMID#PMID_21084293
GOC:jh
http://purl.org/obo/owl/GOC#GOC_jh
PMID:10655211
http://purl.org/obo/owl/PMID#PMID_10655211
PMID:16427013
http://purl.org/obo/owl/PMID#PMID_16427013
eRF1 methyltransferase complex
cellular_component
eRF1 MTase complex
PMID:17008308
http://purl.org/obo/owl/PMID#PMID_17008308
A protein complex required for the methylation of a glutamine (Gln) residue in the protein release factor eRF1. In S. cerevisiae, this complex consists of at least Trm112p and Mtq2p.
PMID:17008308
http://purl.org/obo/owl/PMID#PMID_17008308
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
PMID:20400505
http://purl.org/obo/owl/PMID#PMID_20400505
Mon1-Ccz1 complex
cellular_component
A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p.
PMID:20797862
http://purl.org/obo/owl/PMID#PMID_20797862
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
flagellar fibrous sheath
cellular_component
flagellum fibrous sheath
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat.
PMID:3282552
http://purl.org/obo/owl/PMID#PMID_3282552
PMID:20731842
http://purl.org/obo/owl/PMID#PMID_20731842
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
macrophage migration inhibitory factor receptor complex
cellular_component
A protein complex that binds macrophage migration inhibitory factor. Comprises CD74 and CD44 cell surface proteins.
PMID:17045821
http://purl.org/obo/owl/PMID#PMID_17045821
PMID:12782713
http://purl.org/obo/owl/PMID#PMID_12782713
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
NOS2-CD74 complex
cellular_component
A protein complex comprising nitric oxide synthase 2 and CD74. This stable complex formation is thought to prevent CD74 degradation by caspases.
PMID:18003616
http://purl.org/obo/owl/PMID#PMID_18003616
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
myelin sheath abaxonal region
cellular_component
The region of the myelin sheath furthest from the axon.
PMID:20237282
http://purl.org/obo/owl/PMID#PMID_20237282
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
myelin sheath adaxonal region
cellular_component
The region of the myelin sheath nearest to the axon.
PMID:20237282
http://purl.org/obo/owl/PMID#PMID_20237282
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
ribonucleoprotein granule
cellular_component
RNA granule
A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
PMID:20368989
http://purl.org/obo/owl/PMID#PMID_20368989
PMID:16520386
http://purl.org/obo/owl/PMID#PMID_16520386
PMID:21436445
http://purl.org/obo/owl/PMID#PMID_21436445
GOC:sp
http://purl.org/obo/owl/GOC#GOC_sp
RNP granule
mRNP granule
other organism postsynaptic membrane
cellular_component
A postsynaptic membrane that is part of another organism, i.e. a secondary organism with which the first organism is interacting. A postsynaptic membrane is a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters transmit the signal across the synaptic cleft to the postsynaptic membrane.
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
ATP-binding cassette (ABC) transporter complex, transmembrane substrate-binding subunit-containing
The ECF-type transporters differs from other types of ABC transporters because the substrate-binding subunit lies integral to the membrane.
cellular_component
energy-coupling factor transporter
PMID:18931129
http://purl.org/obo/owl/PMID#PMID_18931129
energy coupling factor (ECF)-type ABC transporter
PMID:21135102
http://purl.org/obo/owl/PMID#PMID_21135102
A complex for the transport of metabolites into the cell, consisting of 4 subunits: a transmembrane substrate-binding protein (known as the S component), and an energy-coupling module that comprises two ATP-binding proteins (known as the A and A' components) and a transmembrane protein (known as the T component). Transport of the substrate across the membrane is driven by the hydrolysis of ATP.
PMID:18931129
http://purl.org/obo/owl/PMID#PMID_18931129
PMID:20972419
http://purl.org/obo/owl/PMID#PMID_20972419
PMID:21135102
http://purl.org/obo/owl/PMID#PMID_21135102
ATP-binding cassette (ABC) transporter complex, ECF-type
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
egg coat
cellular_component
A specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development.
PMID:17163408
http://purl.org/obo/owl/PMID#PMID_17163408
PMID:16944418
http://purl.org/obo/owl/PMID#PMID_16944418
zona pellucida
PMID:17163408
http://purl.org/obo/owl/PMID#PMID_17163408
PMID:16944418
http://purl.org/obo/owl/PMID#PMID_16944418
vitelline membrane
PMID:16944418
http://purl.org/obo/owl/PMID#PMID_16944418
PMID:17163408
http://purl.org/obo/owl/PMID#PMID_17163408
meiotic recombination initiation complex
cellular_component
A protein complex that initiates the formation of double-strand breaks (DSBs) required for meiotic recombination. Consists of a protein that catalyses formation of the double-strand breaks (Spo11 in S. cerevisiae and Rec12 in S. pombe), and a number of accessory proteins.
PMID:12897161
http://purl.org/obo/owl/PMID#PMID_12897161
PMID:20364342
http://purl.org/obo/owl/PMID#PMID_20364342
PMID:21429938
http://purl.org/obo/owl/PMID#PMID_21429938
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
growing cell tip
cellular_component
The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth occurs.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
growing cell end
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
non-growing cell tip
cellular_component
new cell end
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
non-growing cell end
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A cell tip at which no growth takes place. For example, in fission yeast the cell end newly formed by cell division does not grow immediately upon its formation, and lacks actin cytoskeletal structures.
GOC:expert_jd
http://purl.org/obo/owl/GOC#GOC_expert_jd
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
old growing cell tip
cellular_component
old growing cell end
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs. For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures.
GOC:expert_jd
http://purl.org/obo/owl/GOC#GOC_expert_jd
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
new growing cell tip
cellular_component
post-new end take-off new cell tip
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A cell tip that was newly formed at the last cell division, and that has started to grow after the cell has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). New end take-off is when monopolar cells initiate bipolar growth.
GOC:expert_jd
http://purl.org/obo/owl/GOC#GOC_expert_jd
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:19431238
http://purl.org/obo/owl/PMID#PMID_19431238
new cell tip after activation of bipolar cell growth
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
post-NETO new cell end
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
post-NETO new cell tip
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
old cell tip after activation of bipolar cell growth
cellular_component
post-new end take-off old cell tip
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs, which is part of a cell that has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:expert_jd
http://purl.org/obo/owl/GOC#GOC_expert_jd
post-NETO old cell tip
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
post-NETO old cell end
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
endonuclear canal
cellular_component
A membrane-bound structure present in the nucleus of a spermatozoon. There is variation in the number of endonuclear canals between sperm of different organisms, and some species lack these structures altogether. The endonuclear canal may provide a supporting role for the sperm nucleus, and originates during spermiogenesis from an invagination of the nuclear envelope.
PMID:18359585
http://purl.org/obo/owl/PMID#PMID_18359585
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
Seh1-associated complex
cellular_component
A protein complex that associates dynamically with the vacuolar membrane, and is proposed to have a role in membrane-associated trafficking or regulatory processes. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p.
GOC:jh
http://purl.org/obo/owl/GOC#GOC_jh
PMID:21454883
http://purl.org/obo/owl/PMID#PMID_21454883
SEA complex
GOC:jh
http://purl.org/obo/owl/GOC#GOC_jh
PMID:21454883
http://purl.org/obo/owl/PMID#PMID_21454883
site of double-strand break
cellular_component
IRIF
PMID:20096808
http://purl.org/obo/owl/PMID#PMID_20096808
PMID:21035408
http://purl.org/obo/owl/PMID#PMID_21035408
ionizing radiation-induced foci
PMID:21035408
http://purl.org/obo/owl/PMID#PMID_21035408
PMID:20096808
http://purl.org/obo/owl/PMID#PMID_20096808
A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:20096808
http://purl.org/obo/owl/PMID#PMID_20096808
PMID:21035408
http://purl.org/obo/owl/PMID#PMID_21035408
DNA damage foci
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
site of DSB
PMID:21035408
http://purl.org/obo/owl/PMID#PMID_21035408
DNA damage focus
PMID:20096808
http://purl.org/obo/owl/PMID#PMID_20096808
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:21035408
http://purl.org/obo/owl/PMID#PMID_21035408
alphav-beta3 integrin-PKCalpha complex
cellular_component
A protein complex that consists of an alphav-beta3 integrin complex bound to protein kinase C alpha.
PMID:16014375
http://purl.org/obo/owl/PMID#PMID_16014375
GOC:ebc
http://purl.org/obo/owl/GOC#GOC_ebc
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
alphav-beta3 integrin-protein kinase C alpha complex
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
alphav-beta3 integrin-PKCa complex
GOC:ebc
http://purl.org/obo/owl/GOC#GOC_ebc
alphav-beta3 integrin-IGF-1-IGF1R complex
cellular_component
A protein complex that consists of an alphav-beta3 integrin complex bound to insulin-like growth factor-1 (IGF-1) and type I insulin-like growth factor receptor (IGF1R). IGF1R is a heterotetramer that consists of two alpha-subunits and two beta-subunits.
PMID:19578119
http://purl.org/obo/owl/PMID#PMID_19578119
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
GOC:ebc
http://purl.org/obo/owl/GOC#GOC_ebc
alphav-beta3 integrin-HMGB1 complex
cellular_component
alphaV-beta3 integrin-HMGB1 complex
GOC:ebc
http://purl.org/obo/owl/GOC#GOC_ebc
alphav-beta3 integrin-high mobility group box 1 complex
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
A protein complex that consists of an alphav-beta3 integrin complex bound to high mobility group box 1 protein.
GOC:ebc
http://purl.org/obo/owl/GOC#GOC_ebc
PMID:20826760
http://purl.org/obo/owl/PMID#PMID_20826760
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
ciliary transition zone
cellular_component
A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition.
PMID:21422230
http://purl.org/obo/owl/PMID#PMID_21422230
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
meiotic spindle pole body
cellular_component
The microtubule organizing center on a spindle that forms as part of meiosis; functionally homologous to the animal cell centrosome.
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:21775631
http://purl.org/obo/owl/PMID#PMID_21775631
AP1 complex
cellular_component
transcription factor AP1 complex
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
transcription factor AP-1 complex
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
AP-1 complex
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
Activating protein 1 complex
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
PMID:20060892
http://purl.org/obo/owl/PMID#PMID_20060892
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
Wikipedia:AP-1_transcription_factor
http://purl.org/obo/owl/Wikipedia#Wikipedia_AP-1_transcription_factor
PMID:9069263
http://purl.org/obo/owl/PMID#PMID_9069263
senescence-associated heterochromatin focus
cellular_component
SAHF
GOC:yaf
http://purl.org/obo/owl/GOC#GOC_yaf
senescence-associated heterochromatin foci
PMID:21248468
http://purl.org/obo/owl/PMID#PMID_21248468
PMID:15621527
http://purl.org/obo/owl/PMID#PMID_15621527
A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes.
PMID:15621527
http://purl.org/obo/owl/PMID#PMID_15621527
PMID:21248468
http://purl.org/obo/owl/PMID#PMID_21248468
GOC:yaf
http://purl.org/obo/owl/GOC#GOC_yaf
rhabdomere microvillus
cellular_component
Thin cylindrical membrane-covered projection on the surface of a rhabdomere.
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
PMID:14744998
http://purl.org/obo/owl/PMID#PMID_14744998
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
rhabdomere microvillus membrane
cellular_component
The portion of the plasma membrane surrounding a microvillus of a rhabdomere.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
PMID:14744998
http://purl.org/obo/owl/PMID#PMID_14744998
mucocyst
cellular_component
A small subcellular vesicle, surrounded by a membrane, in the pellicle of ciliate protozoans that discharges a mucus-like secretion.
GOC:mag
http://purl.org/obo/owl/GOC#GOC_mag
PMID:4629881
http://purl.org/obo/owl/PMID#PMID_4629881
PMID:10723937
http://purl.org/obo/owl/PMID#PMID_10723937
scintillon
cellular_component
A body present in the cytoplasm of some dinoflagellates, which is the source of bioluminescence; emits light on acidification in the presence of oxygen.
GOC:mag
http://purl.org/obo/owl/GOC#GOC_mag
PMID:5642469
http://purl.org/obo/owl/PMID#PMID_5642469
PMID:4501583
http://purl.org/obo/owl/PMID#PMID_4501583
cyanelle inner membrane
cellular_component
cyanelle inner envelope membrane
PMID:18976493
http://purl.org/obo/owl/PMID#PMID_18976493
The inner, i.e. lumen-facing, lipid bilayer of the cyanelle envelope; also faces the cyanelle stroma.
PMID:18976493
http://purl.org/obo/owl/PMID#PMID_18976493
GOC:aa
http://purl.org/obo/owl/GOC#GOC_aa
cyanelle outer membrane
cellular_component
The outer, i.e. cytoplasm-facing, lipid bilayer of the cyanelle envelope.
GOC:aa
http://purl.org/obo/owl/GOC#GOC_aa
cyanelle intermembrane space
cellular_component
cyanelle periplasm
PMID:18976493
http://purl.org/obo/owl/PMID#PMID_18976493
cyanelle envelope lumen
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
The region between the inner and outer lipid bilayers of the cyanelle envelope; includes the peptidoglycan layer.
GOC:aa
http://purl.org/obo/owl/GOC#GOC_aa
endolysosome
cellular_component
An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place.
GOC:pde
http://purl.org/obo/owl/GOC#GOC_pde
PMID:21878991
http://purl.org/obo/owl/PMID#PMID_21878991
endolysosome membrane
cellular_component
The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome.
GOC:pde
http://purl.org/obo/owl/GOC#GOC_pde
endolysosomal membrane
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
endolysosome lumen
cellular_component
endolysosomal lumen
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
The volume enclosed by the membrane of an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome.
GOC:pde
http://purl.org/obo/owl/GOC#GOC_pde
protein C inhibitor-TMPRSS7 complex
cellular_component
SERPINA5-TMPRSS7 complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
protein C inhibitor-transmembrane protease serine 7 complex
PR:000016461
http://purl.org/obo/owl/PR#PR_000016461
protein C inhibitor-matriptase-3 complex
PMID:15853774
http://purl.org/obo/owl/PMID#PMID_15853774
PR:000016461
http://purl.org/obo/owl/PR#PR_000016461
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 7 (TMPRSS7); formation of the complex inhibits the serine protease activity of transmembrane protease serine 7.
GOC:ans
http://purl.org/obo/owl/GOC#GOC_ans
PMID:15853774
http://purl.org/obo/owl/PMID#PMID_15853774
plasma serine protease inhibitor-TMPRSS7 complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
serpin A5-TMPRSS7 complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
PCI-TMPRSS7 complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
protein C inhibitor-TMPRSS11E complex
cellular_component
serpin A5-TMPRSS11E complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
protein C inhibitor-transmembrane protease serine 11E complex
PR:000016451
http://purl.org/obo/owl/PR#PR_000016451
plasma serine protease inhibitor-TMPRSS11E complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
SERPINA5-TMPRSS11E complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 11E (TMPRSS11E); formation of the complex inhibits the serine protease activity of transmembrane protease serine 11E.
PMID:15328353
http://purl.org/obo/owl/PMID#PMID_15328353
GOC:ans
http://purl.org/obo/owl/GOC#GOC_ans
PCI-TMPRSS11E complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
protein C inhibitor-PLAT complex
cellular_component
plasma serine protease inhibitor-PLAT complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
protein C inhibitor-tissue-type plasminogen activator complex
PR:000012825
http://purl.org/obo/owl/PR#PR_000012825
PMID:10340997
http://purl.org/obo/owl/PMID#PMID_10340997
protein C inhibitor-tPA complex
PR:000012825
http://purl.org/obo/owl/PR#PR_000012825
PMID:10340997
http://purl.org/obo/owl/PMID#PMID_10340997
serpin A5-PLAT complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
SERPINA5-PLAT complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and tissue-type plasminogen activator (PLAT); formation of the complex inhibits the serine protease activity of tissue-type plasminogen activator.
GOC:ans
http://purl.org/obo/owl/GOC#GOC_ans
PMID:10340997
http://purl.org/obo/owl/PMID#PMID_10340997
PCI-PLAT complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
protein C inhibitor-PLAU complex
cellular_component
serpin A5-PLAU complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
SERPINA5-PLAU complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
plasma serine protease inhibitor-PLAU complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
PCI-PLAU complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
protein C inhibitor-uPA complex
PR:000012826
http://purl.org/obo/owl/PR#PR_000012826
protein C inhibitor-U-plasminogen activator complex
PR:000012826
http://purl.org/obo/owl/PR#PR_000012826
protein C inhibitor-urokinase-type plasminogen activator complex
PR:000012826
http://purl.org/obo/owl/PR#PR_000012826
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and urokinase-type plasminogen activator (PLAU); formation of the complex inhibits the serine protease activity of urokinase-type plasminogen activator.
GOC:ans
http://purl.org/obo/owl/GOC#GOC_ans
PMID:8536714
http://purl.org/obo/owl/PMID#PMID_8536714
PMID:10340997
http://purl.org/obo/owl/PMID#PMID_10340997
PMID:3501295
http://purl.org/obo/owl/PMID#PMID_3501295
protein C inhibitor-thrombin complex
cellular_component
protein C inhibitor-F2 complex
PR:000007299
http://purl.org/obo/owl/PR#PR_000007299
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and thrombin (F2); formation of the complex inhibits the serine protease activity of thrombin.
PMID:6323392
http://purl.org/obo/owl/PMID#PMID_6323392
GOC:ans
http://purl.org/obo/owl/GOC#GOC_ans
plasma serine protease inhibitor-thrombin complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
serpin A5-thrombin complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
PCI-thrombin complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
SERPINA5-thrombin complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
protein C inhibitor-coagulation factor II complex
PR:000007299
http://purl.org/obo/owl/PR#PR_000007299
protein C inhibitor-KLK3 complex
cellular_component
serpin A5-KLK3 complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
SERPINA5-KLK3 complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and prostate-specific antigen (KLK3); formation of the complex inhibits the serine protease activity of prostate-specific antigen.
GOC:ans
http://purl.org/obo/owl/GOC#GOC_ans
PMID:1725227
http://purl.org/obo/owl/PMID#PMID_1725227
plasma serine protease inhibitor-KLK3 complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
PCI-KLK3 complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
protein C inhibitor-prostate-specific antigen complex
PR:000003015
http://purl.org/obo/owl/PR#PR_000003015
protein C inhibitor-kallikrein-3 complex
PR:000003015
http://purl.org/obo/owl/PR#PR_000003015
protein C inhibitor-plasma kallikrein complex
cellular_component
plasma serine protease inhibitor-plasma kallikrein complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
serpin A5-plasma kallikrein complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
PCI-plasma kallikrein complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and plasma kallikrein (KLK1B); formation of the complex inhibits the serine protease activity of plasma kallikrein.
PMID:8536714
http://purl.org/obo/owl/PMID#PMID_8536714
PMID:2844223
http://purl.org/obo/owl/PMID#PMID_2844223
GOC:ans
http://purl.org/obo/owl/GOC#GOC_ans
protein C inhibitor-KLKB1 complex
PR:000009420
http://purl.org/obo/owl/PR#PR_000009420
SERPINA5-plasma kallikrein complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
TCTN-B9D complex
cellular_component
tectonic complex
tectonic-like complex
A protein complex that is located at the ciliary transition zone and consists of tectonic proteins, B9 domain-containing proteins and other proteins. Acts as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. In mouse, members of the complex include TCTN1, TCTN2, B9D1, MKS1, CC2D2A and other proteins.
GOC:sp
http://purl.org/obo/owl/GOC#GOC_sp
PMID:21725307
http://purl.org/obo/owl/PMID#PMID_21725307
PMID:22179047
http://purl.org/obo/owl/PMID#PMID_22179047
B9 complex
microspike
This term was made obsolete because it accidentally reused an exisiting id. See replacement term GO:0044393.
cellular_component
OBSOLETE. A dynamic, actin-rich projection extending from the surface of a migrating animal cell.
PMID:12153987
http://purl.org/obo/owl/PMID#PMID_12153987
PMID:19095735
http://purl.org/obo/owl/PMID#PMID_19095735
PMID:11429692
http://purl.org/obo/owl/PMID#PMID_11429692
glomerular endothelium fenestra
cellular_component
A large plasma membrane-lined circular pore that perforates the flattened glomerular endothelium and, unlike those of other fenestrated capillaries, is not spanned by diaphragms; the density and size of glomerular fenestrae account, at least in part, for the high permeability of the glomerular capillary wall to water and small solutes.
PMID:19129259
http://purl.org/obo/owl/PMID#PMID_19129259
GOC:cjm
http://purl.org/obo/owl/GOC#GOC_cjm
MP:0011454
http://purl.org/obo/owl/MP#MP_0011454
GEnC fenestration
PMID:19129259
http://purl.org/obo/owl/PMID#PMID_19129259
glomerular endothelial cell fenestration
PMID:19129259
http://purl.org/obo/owl/PMID#PMID_19129259
filtration diaphragm
cellular_component
A specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph.
PMID:18971929
http://purl.org/obo/owl/PMID#PMID_18971929
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
GOC:mtg_kidney_jan10
http://purl.org/obo/owl/GOC#GOC_mtg_kidney_jan10
slit diaphragm
cellular_component
A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration.
PMID:19478094
http://purl.org/obo/owl/PMID#PMID_19478094
PMID:18971929
http://purl.org/obo/owl/PMID#PMID_18971929
PMID:15994232
http://purl.org/obo/owl/PMID#PMID_15994232
PMID:12386277
http://purl.org/obo/owl/PMID#PMID_12386277
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
GOC:mtg_kidney_jan10
http://purl.org/obo/owl/GOC#GOC_mtg_kidney_jan10
presynaptic periactive zone
cellular_component
A region that surrounds the active zone of the presynaptic plasma membrane, and is specialized for the control of synaptic development.
PMID:10976048
http://purl.org/obo/owl/PMID#PMID_10976048
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
PMID:18439406
http://purl.org/obo/owl/PMID#PMID_18439406
periactive zone
PMID:18439406
http://purl.org/obo/owl/PMID#PMID_18439406
PMID:10976048
http://purl.org/obo/owl/PMID#PMID_10976048
acroblast
See also the fly_anatomy.ontology term 'acroblast ; FBbt:00004947'.
cellular_component
spermatid acroblast
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
A cone-shaped structure in the head of a spermatozoon, which is formed by the coalescence of Golgi fragments following the completion of meiosis. The acroblast is situated adjacent to the acrosomal vesicle.
PMID:19934220
http://purl.org/obo/owl/PMID#PMID_19934220
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
cilium basal body
cellular_component
ciliary basal body
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
A membrane-tethered derivative of the centriole, and the site of assembly and remodelling of the cilium. As well as anchoring the cilium, the basal body is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
PMID:21750193
http://purl.org/obo/owl/PMID#PMID_21750193
glutathione synthase complex
cellular_component
A protein complex composed of two or more polypeptide subunits, and which possesses glutathione synthase activity (catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate). In eukaryotes, the complex is homodimeric, in E. coli glutathione synthase exists as a tetramer, and in S. pombe the complex exists as a homodimer or a heterotetramer.
PMID:14990577
http://purl.org/obo/owl/PMID#PMID_14990577
PMID:12734194
http://purl.org/obo/owl/PMID#PMID_12734194
PMID:1958212
http://purl.org/obo/owl/PMID#PMID_1958212
GOC:al
http://purl.org/obo/owl/GOC#GOC_al
glutathione synthetase complex
PMID:12734194
http://purl.org/obo/owl/PMID#PMID_12734194
PMID:14990577
http://purl.org/obo/owl/PMID#PMID_14990577
PMID:1958212
http://purl.org/obo/owl/PMID#PMID_1958212
hyaluranon cable
cellular_component
HA cable
PMID:16900089
http://purl.org/obo/owl/PMID#PMID_16900089
A cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan.
GOC:yaf
http://purl.org/obo/owl/GOC#GOC_yaf
PMID:16900089
http://purl.org/obo/owl/PMID#PMID_16900089
fatty acid beta-oxidation multienzyme complex
For fatty acid beta-oxidation multienzyme complexes located in the mitochondrial matrix, consider instead the term 'mitochondrial fatty acid beta-oxidation multienzyme complex ; GO:0016507'.
cellular_component
A multienzyme complex possessing three kinds of enzymes that catalyze the chain reactions in the fatty acid beta-oxidation cycle, enoyl-CoA hydratase (ECH), 3-hydroxyacyl-CoA dehydrogenase (HACD), and acetyl-CoA C-acyltransferase (KACT).
GOC:imk
http://purl.org/obo/owl/GOC#GOC_imk
PMID:12115060
http://purl.org/obo/owl/PMID#PMID_12115060
PMID:16472743
http://purl.org/obo/owl/PMID#PMID_16472743
sperm flagellum
cellular_component
A microtubule-based flagellum that is part of a sperm, a mature male germ cell that develops from a spermatid.
PMID:8441407
http://purl.org/obo/owl/PMID#PMID_8441407
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
sperm tail
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
CatSper complex
cellular_component
CATSPER channel
PMID:21224844
http://purl.org/obo/owl/PMID#PMID_21224844
A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits.
GOC:sp
http://purl.org/obo/owl/GOC#GOC_sp
PMID:17478420
http://purl.org/obo/owl/PMID#PMID_17478420
PMID:22354039
http://purl.org/obo/owl/PMID#PMID_22354039
PMID:21224844
http://purl.org/obo/owl/PMID#PMID_21224844
CatSper channel complex
PMID:17478420
http://purl.org/obo/owl/PMID#PMID_17478420
inner dynein arm
cellular_component
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
PMID:19347929
http://purl.org/obo/owl/PMID#PMID_19347929
GOC:vk
http://purl.org/obo/owl/GOC#GOC_vk
PMID:2557057
http://purl.org/obo/owl/PMID#PMID_2557057
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
PMID:7962092
http://purl.org/obo/owl/PMID#PMID_7962092
inner dynein arm complex
outer dynein arm
cellular_component
Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
PMID:6218174
http://purl.org/obo/owl/PMID#PMID_6218174
PMID:2557057
http://purl.org/obo/owl/PMID#PMID_2557057
GOC:vk
http://purl.org/obo/owl/GOC#GOC_vk
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
outer dynein arm complex
early phagosome membrane
cellular_component
The lipid bilayer surrounding an early phagosome.
GOC:phg
http://purl.org/obo/owl/GOC#GOC_phg
early phagocytic vesicle membrane
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
muscle cell projection
cellular_component
A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns.
PMID:15930100
http://purl.org/obo/owl/PMID#PMID_15930100
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
PMID:22464329
http://purl.org/obo/owl/PMID#PMID_22464329
CL:0000187
http://purl.org/obo/owl/CL#CL_0000187
myopodia
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
myocyte projection
CL:0000187
http://purl.org/obo/owl/CL#CL_0000187
muscle arm
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
muscle cell projection membrane
cellular_component
The portion of the plasma membrane surrounding a muscle cell projection.
CL:0000187
http://purl.org/obo/owl/CL#CL_0000187
PMID:22464329
http://purl.org/obo/owl/PMID#PMID_22464329
PMID:15930100
http://purl.org/obo/owl/PMID#PMID_15930100
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
pairing center
cellular_component
homolog recognition region
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
A special chromosome region located towards one end of a chromosome that contains dispersed copies of short, repetitive DNA sequences and functions as a cis-acting element essential for presynaptic homologous chromosome pairing and chromosome-nuclear envelope attachment.
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
PMID:18597662
http://purl.org/obo/owl/PMID#PMID_18597662
septal periplasm
cellular_component
The region between the plasma membrane and the cell wall, as found in organisms such as filamentous fungi.
PMID:21564341
http://purl.org/obo/owl/PMID#PMID_21564341
GOC:di
http://purl.org/obo/owl/GOC#GOC_di
cell wall-enclosed septal periplasm
GOC:di
http://purl.org/obo/owl/GOC#GOC_di
G-protein coupled receptor dimeric complex
cellular_component
G-protein coupled receptor dimer
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
GPCR dimer
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
A protein complex that contains two G-protein coupled receptors.
GOC:al
http://purl.org/obo/owl/GOC#GOC_al
PMID:10713101
http://purl.org/obo/owl/PMID#PMID_10713101
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
G-protein coupled receptor homodimeric complex
cellular_component
G-protein coupled receptor homodimer
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
GPCR homodimer
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
A protein complex that contains two G-protein coupled receptors (GPCRs) of the same subtype. Formation of a GPCR homodimer may be important for the transport of newly formed receptors to the cell surface, and the function of the receptor.
PMID:16670762
http://purl.org/obo/owl/PMID#PMID_16670762
PMID:10713101
http://purl.org/obo/owl/PMID#PMID_10713101
GOC:al
http://purl.org/obo/owl/GOC#GOC_al
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
G-protein coupled receptor heterodimeric complex
cellular_component
A protein complex that contains two G-protein coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR.
GOC:al
http://purl.org/obo/owl/GOC#GOC_al
PMID:20150590
http://purl.org/obo/owl/PMID#PMID_20150590
PMID:16109836
http://purl.org/obo/owl/PMID#PMID_16109836
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
G-protein coupled receptor heterodimer
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
GPCR heterodimer
PMID:20150590
http://purl.org/obo/owl/PMID#PMID_20150590
large latent transforming growth factor-beta complex
cellular_component
LLC
Reactome:REACT_6888.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_6888.1
large latent complex
Reactome:REACT_6888.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_6888.1
A protein complex containing latency-associated proteins (LAPs), mature disulphide-linked dimeric TGF-beta, and latent TGF-beta binding proteins (LTBPs). TGF-beta is mostly secreted as part of the large latent complex, and must be subsequently released from the LLC in order to bind to cell surface receptors.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
PMID:2350783
http://purl.org/obo/owl/PMID#PMID_2350783
Reactome:REACT_6888.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_6888.1
PMID:8680476
http://purl.org/obo/owl/PMID#PMID_8680476
PMID:9805445
http://purl.org/obo/owl/PMID#PMID_9805445
IKKalpha-IKKalpha complex
cellular_component
IkappaB kinase alpha homodimer
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
A homodimeric protein complex containing two IkappaB kinase (IKK) alpha subunits.
PMID:18626576
http://purl.org/obo/owl/PMID#PMID_18626576
PMID:21173796
http://purl.org/obo/owl/PMID#PMID_21173796
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
IKKalpha homodimeric complex
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
IKKalpha-IKKalpha protein complex
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
IkappaB kinase-alpha homodimer
PMID:21173796
http://purl.org/obo/owl/PMID#PMID_21173796
IKKalpha homodimer
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
nodal receptor complex
Nodal signals through activin receptors but (unlike activin) also requires EGF-CFC coreceptors (such as Cripto or Cryptic in mammals) to signal. This term is intended for receptor/co-receptor components and not a nodal-receptor complex.
cellular_component
A protein complex containing at least a type II activin receptor, a type I activin receptor, and a coreceptor (EGF-CFC protein) such as Cripto or Cryptic. Nodal receptor complexes are capable of binding a nodal protein and transducing the signal into the cell.
PMID:15062104
http://purl.org/obo/owl/PMID#PMID_15062104
GOC:signaling
http://purl.org/obo/owl/GOC#GOC_signaling
PMID:11024047
http://purl.org/obo/owl/PMID#PMID_11024047
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
ActRIIB.ALK4.EGF-CFC complex
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
ERBB4-EGFR complex
cellular_component
ERBB4:EGFR heterodimer
Reactome:REACT_116654.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_116654.1
EGFR-ERBB4 complex
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and epidermal growth factor receptor (EGFR/ERBB1).
Reactome:REACT_116654.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_116654.1
PMID:16460914
http://purl.org/obo/owl/PMID#PMID_16460914
GOC:signaling
http://purl.org/obo/owl/GOC#GOC_signaling
Reactome:REACT_116654.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_116654.1
ERBB4-ERBB3 complex
cellular_component
A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and ERBB3 (also called HER3). ERBB3 has impaired kinase activity so relies on the kinase activity of its heterodimer partner for activation and signal transmission.
Reactome:REACT_117805.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_117805.1
GOC:signaling
http://purl.org/obo/owl/GOC#GOC_signaling
PMID:16460914
http://purl.org/obo/owl/PMID#PMID_16460914
ERBB3-ERBB4 complex
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
Reactome:REACT_117805.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_117805.1
ERBB4:ERBB3 heterodimer
Reactome:117805.1
http://purl.org/obo/owl/Reactome#Reactome_117805.1
ERBB4-ERBB4 complex
cellular_component
A homodimeric complex containing two monomers of the tyrosine kinase receptor ERBB4 (also called HER4).
GOC:signaling
http://purl.org/obo/owl/GOC#GOC_signaling
PMID:16460914
http://purl.org/obo/owl/PMID#PMID_16460914
Reactome:REACT_117065.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_117065.1
Reactome:REACT_117065.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_117065.1
ERBB4 homodimer
Reactome:REACT_117805.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_117805.1
EGFR:ERBB2 complex
cellular_component
EGF:EGFR:ERBB2 complex
Reactome:REACT_116379.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_116379.1
Reactome:REACT_116379.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_116379.1
A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated epidermal growth factor receptor (EGFR/ERBB1). ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR.
PMID:16460914
http://purl.org/obo/owl/PMID#PMID_16460914
PMID:1973074
http://purl.org/obo/owl/PMID#PMID_1973074
Reactome:REACT_115761.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_115761.1
GOC:signaling
http://purl.org/obo/owl/GOC#GOC_signaling
Reactome:REACT_117594.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_117594.1
Reactome:REACT_116379.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_116379.1
EGFR:ERBB2 heterodimer
Reactome:REACT_116379.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_116379.1
ERBB3:ERBB2 complex
cellular_component
A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3.
PMID:16460914
http://purl.org/obo/owl/PMID#PMID_16460914
GOC:signaling
http://purl.org/obo/owl/GOC#GOC_signaling
PMID:8665853
http://purl.org/obo/owl/PMID#PMID_8665853
Reactome:REACT_115761.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_115761.1
Reactome:REACT_116379.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_116379.1
Reactome:REACT_117748.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_117748.1
EGFR:ERBB2 heterodimer
Reactome:REACT_116379.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_116379.1
NRG1/2:ERBB3:ERBB2
Reactome:REACT_117748.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_117748.1
Reactome:REACT_116379.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_116379.1
ERBB4:ERBB2 complex
cellular_component
NRGs/EGFLs:ERBB4:ERBB2
Reactome:REACT_116375.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_116375.1
Reactome:REACT_116379.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_116379.1
ERBB4:ERBB2 heterodimer
Reactome:REACT_116375.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_116375.1
A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4.
Reactome:REACT_115761.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_115761.1
PMID:16978839
http://purl.org/obo/owl/PMID#PMID_16978839
PMID:16460914
http://purl.org/obo/owl/PMID#PMID_16460914
GOC:signaling
http://purl.org/obo/owl/GOC#GOC_signaling
Reactome:REACT_116379.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_116379.1
Reactome:REACT_116375.1
http://purl.org/obo/owl/Reactome#Reactome_REACT_116375.1
interleukin-12 receptor complex
cellular_component
IL-12 receptor complex
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A protein complex that binds interleukin-12; comprises a beta1 and a beta2 subunit.
GOC:ebc
http://purl.org/obo/owl/GOC#GOC_ebc
PMID:10971505
http://purl.org/obo/owl/PMID#PMID_10971505
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
IL12RB1-IL12RB2 complex
CORUM:2026
http://purl.org/obo/owl/CORUM#CORUM_2026
host cell nucleus
GO:0033649
cellular_component
A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
T cell receptor complex
cellular_component
Wikipedia:T_cell_receptor
http://purl.org/obo/owl/Wikipedia#Wikipedia_T_cell_receptor
TCR
A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.
ISBN:0781735149
http://purl.org/obo/owl/ISBN#ISBN_0781735149
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
T-lymphocyte receptor complex
T-cell receptor complex
T lymphocyte receptor complex
alpha-beta T cell receptor complex
cellular_component
A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0781735149
http://purl.org/obo/owl/ISBN#ISBN_0781735149
alpha-beta T lymphocyte receptor complex
alpha-beta T-lymphocyte receptor complex
alpha-beta T-cell receptor complex
alpha-beta TCR complex
gamma-delta T cell receptor complex
cellular_component
gamma-delta T lymphocyte receptor complex
gamma-delta T-cell receptor complex
A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0781735149
http://purl.org/obo/owl/ISBN#ISBN_0781735149
gamma-delta T-lymphocyte receptor complex
gamma-delta TCR complex
nematocyst
cellular_component
cnidocyst
Wikipedia:Cnidocyte
http://purl.org/obo/owl/Wikipedia#Wikipedia_Cnidocyte
An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
DOI:10.1139/z02-135
http://purl.org/obo/owl/DOI#DOI_10.1139/z02-135
plastid membrane
cellular_component
Either of the lipid bilayers that surround a plastid and form the plastid envelope.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
nuclear outer membrane-endoplasmic reticulum membrane network
cellular_component
nuclear membrane-endoplasmic reticulum continuum
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
nuclear membrane-ER network
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
NE-ER continuum
The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
GOC:pr
http://purl.org/obo/owl/GOC#GOC_pr
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
NE-ER network
nuclear envelope-endoplasmic reticulum continuum
nuclear envelope-endoplasmic reticulum network
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
nuclear envelope-ER network
nuclear RNA export factor complex
cellular_component
A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm.
PMID:11780633
http://purl.org/obo/owl/PMID#PMID_11780633
Mex67-Mtr2 complex
NXF1-NXT1 complex
TAP-p15 complex
paraspeckles
cellular_component
Wikipedia:Paraspeckle
http://purl.org/obo/owl/Wikipedia#Wikipedia_Paraspeckle
Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:11790299
http://purl.org/obo/owl/PMID#PMID_11790299
sarcolemma
cellular_component
Wikipedia:Sarcolemma
http://purl.org/obo/owl/Wikipedia#Wikipedia_Sarcolemma
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
myosin III complex
cellular_component
A myosin complex containing a class III myosin heavy chain and associated light chains; myosin III is monomeric myosin that serves as a link between the cytoskeleton and the signaling complex involved in phototransduction, and differs from all other myosins in having an N-terminal kinase domain.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
URL:http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
nuclear inclusion body
cellular_component
An intranuclear focus at which aggregated proteins have been sequestered.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
extrinsic to endoplasmic reticulum membrane
cellular_component
extrinsic to ER membrane
Loosely bound to one surface of the endoplasmic reticulum membrane, but not integrated into the hydrophobic region.
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
melanosome
cellular_component
A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
PMID:11584301
http://purl.org/obo/owl/PMID#PMID_11584301
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
Wikipedia:Melanosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Melanosome
MCM complex
cellular_component
mini-chromosome maintenance complex
A hexameric protein complex required for the initiation and regulation of DNA replication.
PMID:11282021
http://purl.org/obo/owl/PMID#PMID_11282021
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
importin alpha-subunit nuclear export complex
cellular_component
A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha-subunit/CAS/Ran, and which functions to shuttle the importin alpha-subunit out of the nucleus through the nuclear pore.
PMID:9323134
http://purl.org/obo/owl/PMID#PMID_9323134
PMID:9323123
http://purl.org/obo/owl/PMID#PMID_9323123
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
NLS-dependent protein nuclear import complex
cellular_component
A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha and beta-subunits and any protein which has a nuclear localization sequence (NLS). The complex acts to import proteins with an NLS into the nucleus through a nuclear pore.
PMID:9323123
http://purl.org/obo/owl/PMID#PMID_9323123
PMID:9323134
http://purl.org/obo/owl/PMID#PMID_9323134
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
RNA nuclear export complex
cellular_component
A complex which usually consists of three components, e.g. in Xenopus and yeast, the export receptor CRM1 (also known as exportin 1), the Ran protein and any RNA with a nuclear export sequence (NES). The complex acts to export RNA molecules with a NES from the nucleus through a nuclear pore.
PMID:9323123
http://purl.org/obo/owl/PMID#PMID_9323123
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
hydrogenosome
cellular_component
A spherical, membrane-bounded organelle found in some anaerobic protozoa, which participates in ATP and molecular hydrogen formation.
PMID:11197234
http://purl.org/obo/owl/PMID#PMID_11197234
PMID:11293569
http://purl.org/obo/owl/PMID#PMID_11293569
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
Wikipedia:Hydrogenosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Hydrogenosome
insulin-like growth factor ternary complex
cellular_component
IGF ternary complex
A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development.
PMID:12239079
http://purl.org/obo/owl/PMID#PMID_12239079
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
insulin-like growth factor binary complex
cellular_component
IGF binary complex
A complex of two proteins, which in animals is 50kDa and consists of the insulin-like growth factor (IGF) and one of the insulin-like growth factor binding protein-1 (IGFBP-1), -2 (IGFBP-2), -4 (IGFBP-4) and -6 (IGFBP-6). The complex plays a role in growth and development.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:12239079
http://purl.org/obo/owl/PMID#PMID_12239079
immunoglobulin complex, circulating
Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
cellular_component
An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
ISBN:0781735149
http://purl.org/obo/owl/ISBN#ISBN_0781735149
antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
Wikipedia:Antibody
http://purl.org/obo/owl/Wikipedia#Wikipedia_Antibody
DNA polymerase complex
cellular_component
A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:12045093
http://purl.org/obo/owl/PMID#PMID_12045093
microbody
cellular_component
Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
Wikipedia:Microbody
http://purl.org/obo/owl/Wikipedia#Wikipedia_Microbody
mannosome
cellular_component
A specialised tubular organelle, assembled in hexagonal bundles within an external membrane. Mannosomes are specific to molluscs and are thought to be involved in a general stress reaction.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:9799531
http://purl.org/obo/owl/PMID#PMID_9799531
PMID:11912051
http://purl.org/obo/owl/PMID#PMID_11912051
specific granule
cellular_component
secondary granule
Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
ISBN:0721662544
http://purl.org/obo/owl/ISBN#ISBN_0721662544
PMID:7334549
http://purl.org/obo/owl/PMID#PMID_7334549
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
Wikipedia:Specific_granule
http://purl.org/obo/owl/Wikipedia#Wikipedia_Specific_granule
azurophil granule
cellular_component
Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:17152095
http://purl.org/obo/owl/PMID#PMID_17152095
primary granule
chromaffin granule
cellular_component
Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:19158310
http://purl.org/obo/owl/PMID#PMID_19158310
PMID:1961743
http://purl.org/obo/owl/PMID#PMID_1961743
chromaffin granule membrane
cellular_component
The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
germinal vesicle
cellular_component
primary oocyte nucleus
The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity.
PMID:19019837
http://purl.org/obo/owl/PMID#PMID_19019837
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
glycogen granule
cellular_component
NIF_Subcellular:sao1081228141
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1081228141
Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface.
PMID:12179957
http://purl.org/obo/owl/PMID#PMID_12179957
URL:http://148.216.10.83/cellbio/the_mi19.gif
http://148.216.10.83/cellbio/the_mi19.gif
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
glycogen particle
zymogen granule
cellular_component
A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
zymogen granule membrane
cellular_component
The lipid bilayer surrounding a zymogen granule.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
periplasmic space
GO:0005620
cellular_component
periplasm
The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or inner membrane and cell wall (Fungi).
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
vesicular fraction
Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. It is advised that this term should only be used in a manual annotation statement where it is possible to apply an experimental evidence code and only if no other experimental evidence exists for an equivalent in vivo subcellular location.
cellular_component
Any of the small, heterogeneous, artifactual, vesicular particles that are formed when some cells are homogenized.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
lamellar body
cellular_component
Odland body
NIF_Subcellular:sao1379604862
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1379604862
lamellar granule
membrane-coating granule
keratinosome
A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
GOC:cjm
http://purl.org/obo/owl/GOC#GOC_cjm
PMID:12243725
http://purl.org/obo/owl/PMID#PMID_12243725
URL:http://en.wikipedia.org/wiki/Lamellar_granule
http://en.wikipedia.org/wiki/Lamellar_granule
chorion
Note that this term does not refer to the extraembryonic membrane surrounding the embryo of amniote vertebrates as this is an anatomical structure and is therefore not covered by GO.
cellular_component
A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
ISBN:0721662544
http://purl.org/obo/owl/ISBN#ISBN_0721662544
endospore-forming forespore
cellular_component
Portion of the cell formed during the process of bacterial sporulation that will ultimately become the core of the endospore. An endospore is a type of dormant cell that is resistant to adverse conditions.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0697286029
http://purl.org/obo/owl/ISBN#ISBN_0697286029
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
capsule
cellular_component
GO:0030113
GO:0042604
Wikipedia:Capsule_(microbiology)
http://purl.org/obo/owl/Wikipedia#Wikipedia_Capsule_(microbiology)
A protective structure surrounding some fungi and bacteria, attached externally to the cell wall and composed primarily of polysaccharides. Capsules are highly organized structures that adhere strongly to cells and can not be easily removed. Capsules play important roles in pathogenicity, preventing phagocytosis by other cells, adherance, and resistance to dessication.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
MHC protein complex
cellular_component
A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
PMID:15928678
http://purl.org/obo/owl/PMID#PMID_15928678
ISBN:0781735149
http://purl.org/obo/owl/ISBN#ISBN_0781735149
PMID:16153240
http://purl.org/obo/owl/PMID#PMID_16153240
MHC class I protein complex
See also the cellular component term 'MHC class I peptide loading complex ; GO:0042824'.
cellular_component
A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
ISBN:0120781859
http://purl.org/obo/owl/ISBN#ISBN_0120781859
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
ISBN:0781735149
http://purl.org/obo/owl/ISBN#ISBN_0781735149
MHC class II protein complex
cellular_component
A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen.
PMID:15928678
http://purl.org/obo/owl/PMID#PMID_15928678
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
ISBN:0120781859
http://purl.org/obo/owl/ISBN#ISBN_0120781859
photoreceptor outer segment membrane
cellular_component
The membrane surrounding the outer segment of a vertebrate photoreceptor.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
chylomicron
cellular_component
A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues.
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
PMID:10580165
http://purl.org/obo/owl/PMID#PMID_10580165
URL:http://biotech.icmb.utexas.edu/search/dict-search.html
http://biotech.icmb.utexas.edu/search/dict-search.html
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
Wikipedia:Chylomicron
http://purl.org/obo/owl/Wikipedia#Wikipedia_Chylomicron
mast cell granule
cellular_component
Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase.
PMID:12360215
http://purl.org/obo/owl/PMID#PMID_12360215
URL:http://www.ijp-online.com/archives/1969/001/02/r0000-0000tc.htm
http://www.ijp-online.com/archives/1969/001/02/r0000-0000tc.htm
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
actomyosin
cellular_component
actomyosin structure
actomyosin complex
Any complex of actin, myosin, and accessory proteins.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
actomyosin, myosin complex part
cellular_component
The myosin part of any complex of actin, myosin, and accessory proteins.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
actomyosin, actin part
cellular_component
The actin part of any complex of actin, myosin, and accessory proteins.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
chloroplast nucleoid
cellular_component
The region of a chloroplast to which the DNA is confined.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
mitochondrial nucleoid
cellular_component
The region of a mitochondrion to which the DNA is confined.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
plastid nucleoid
cellular_component
The region of a plastid to which the DNA is confined.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
proplastid nucleoid
cellular_component
The region of a proplastid to which the DNA is confined.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
chloroplast chromosome
cellular_component
A circular DNA molecule containing chloroplast encoded genes.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
prothylakoid
cellular_component
Underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. Rapidly develop into mature thylakoids in the presence of light.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:11532175
http://purl.org/obo/owl/PMID#PMID_11532175
prothylakoid membrane
cellular_component
The membrane of prothylakoids, underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes.
PMID:11532175
http://purl.org/obo/owl/PMID#PMID_11532175
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
thylakoid membrane
cellular_component
The pigmented membrane of any thylakoid.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
mitochondrial respiratory chain complex I, peripheral segment
cellular_component
NADH-Q oxidoreductase complex, peripheral segment
NADH dehydrogenase (ubiquinone) complex, peripheral segment
The peripheral segment of respiratory chain complex I located in the mitochondrion. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix.
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0716749556
http://purl.org/obo/owl/ISBN#ISBN_0716749556
mitochondrial respiratory chain complex I, membrane segment
cellular_component
NADH-Q oxidoreductase complex, membrane segment
The mitochondrial membrane segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix.
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0716749556
http://purl.org/obo/owl/ISBN#ISBN_0716749556
succinate-CoA ligase complex
cellular_component
A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP.
EC:6.2.1.4
http://purl.org/obo/owl/EC#EC_6.2.1.4
EC:6.2.1.5
http://purl.org/obo/owl/EC#EC_6.2.1.5
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
plasma membrane-derived chromatophore
Note that this structure is distinct from the chromoplast of plants, which is also sometimes called a chromatophore; it also should not be confused with the specialized pigment-producing cells known as chromatophores, found in fish and amphibian skin.
cellular_component
A pigment-bearing structure that is derived from the cytoplasmic membrane, sometimes consisting of simple invaginations and sometimes a complete vesicle. This component is found in certain photosynthetic bacteria and cyanobacteria.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
ISBN:0395825172
http://purl.org/obo/owl/ISBN#ISBN_0395825172
PMID:11867431
http://purl.org/obo/owl/PMID#PMID_11867431
chromatophore vesicle
plasma membrane-derived chromatophore membrane
cellular_component
The lipid bilayer associated with a plasma membrane-derived chromatophore; surrounds chromatophores that form complete vesicles.
PMID:11867431
http://purl.org/obo/owl/PMID#PMID_11867431
ISBN:0395825172
http://purl.org/obo/owl/ISBN#ISBN_0395825172
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
yolk granule
cellular_component
Discrete structures that partition the water-insoluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed.
URL:http://148.216.10.83/cellbio/eggs.htm
http://148.216.10.83/cellbio/eggs.htm
PMID:18046696
http://purl.org/obo/owl/PMID#PMID_18046696
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
mitochondrial intermembrane space protein transporter complex
cellular_component
Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane.
PMID:12581629
http://purl.org/obo/owl/PMID#PMID_12581629
Tim9-Tim10 complex
mitochondrial inner membrane peptidase complex
cellular_component
IMP
Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space.
PMID:12191769
http://purl.org/obo/owl/PMID#PMID_12191769
PMID:10821182
http://purl.org/obo/owl/PMID#PMID_10821182
mitochondrial inner membrane protein insertion complex
cellular_component
A multi-subunit complex embedded in the mitochondrial inner membrane that mediates insertion of carrier proteins into the inner membrane.
PMID:12191765
http://purl.org/obo/owl/PMID#PMID_12191765
Tim22 complex
DASH complex
Note that this complex is conserved in fungi but has not been observed in metazoans.
cellular_component
GO:0043925
GO:0043926
condensed nuclear chromosome kinetochore-associated DASH complex
Dam1 complex
DDD complex
Duo1p-Dam1p-Dad1p complex
A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability.
PMID:11799062
http://purl.org/obo/owl/PMID#PMID_11799062
PMID:11782438
http://purl.org/obo/owl/PMID#PMID_11782438
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
presynaptic membrane
cellular_component
A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
protein body
cellular_component
A membrane-bounded plant organelle found in the developing endosperm, contains storage proteins.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:7704047
http://purl.org/obo/owl/PMID#PMID_7704047
giant axon
cellular_component
Extremely large, unmyelinated axon found in invertebrates. Has high conduction speeds and is usually involved in panic or escape responses.
PMID:9705477
http://purl.org/obo/owl/PMID#PMID_9705477
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
intracellular immature spore
cellular_component
A cell or part of the cell that constitutes an early developmental stage of a spore, a small reproductive body that is highly resistant to desiccation and heat and is capable of growing into a new organism, produced especially by certain bacteria, fungi, algae, and nonflowering plants.
ISBN:0395825172
http://purl.org/obo/owl/ISBN#ISBN_0395825172
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
forespore
ascospore-type prospore
cellular_component
An immature spore undergoing development. The spore usually consists of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s). This type of spore is observed in ascopore-forming fungi.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
GPI-anchor transamidase complex
Note that this term should not be confused with 'glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ; GO:0000506', which represents a distinct complex with a different catalytic activity.
cellular_component
An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
PMID:12802054
http://purl.org/obo/owl/PMID#PMID_12802054
GPIT complex
polysomal ribosome
cellular_component
active ribosome
A ribosome bound to mRNA that forms part of a polysome.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
central vacuole
cellular_component
A membrane-enclosed sac that takes up most of the volume of a mature plant cell. Functions include storage, separation of toxic byproducts, and cell growth determination.
Wikipedia:Vacuole
http://purl.org/obo/owl/Wikipedia#Wikipedia_Vacuole
ISBN:9780815341116
http://purl.org/obo/owl/ISBN#ISBN_9780815341116
MHC class I peptide loading complex
Note that although this complex is located in the endoplasmic reticulum, there is some evidence that it may also be found in the Golgi.
cellular_component
A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.
PMID:10631934
http://purl.org/obo/owl/PMID#PMID_10631934
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
TAP complex
cellular_component
transporter associated with antigen presentation
A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:10618487
http://purl.org/obo/owl/PMID#PMID_10618487
PMID:10631934
http://purl.org/obo/owl/PMID#PMID_10631934
platelet dense granule
cellular_component
bull's eye body
Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:10403682
http://purl.org/obo/owl/PMID#PMID_10403682
PMID:11487378
http://purl.org/obo/owl/PMID#PMID_11487378
URL:http://www.mercksource.com/
http://www.mercksource.com/
platelet dense body
cell projection
cellular_component
cellular projection
A prolongation or process extending from a cell, e.g. a flagellum or axon.
URL:http://www.cogsci.princeton.edu/~wn/
http://www.cogsci.princeton.edu/~wn/
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
cell process
cellular process
neuron projection
cellular_component
neuron protrusion
neuronal cell projection
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
URL:http://www.cogsci.princeton.edu/~wn/
http://www.cogsci.princeton.edu/~wn/
NIF_Subcellular:sao-867568886
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao-867568886
neuron process
neurite
NADPH oxidase complex
cellular_component
A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:11483596
http://purl.org/obo/owl/PMID#PMID_11483596
PMID:12440767
http://purl.org/obo/owl/PMID#PMID_12440767
flavocytochrome b558
respiratory-burst oxidase
neuronal cell body
Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.
cellular_component
neuronal cell soma
NIF_Subcellular:sao1044911821
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1044911821
The portion of a neuron that includes the nucleus, but excludes all cell projections such as axons and dendrites.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
Wikipedia:Soma_(biology)
http://purl.org/obo/owl/Wikipedia#Wikipedia_Soma_(biology)
neuron cell body
isoamylase complex
cellular_component
debranching enzyme complex
A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:10333591
http://purl.org/obo/owl/PMID#PMID_10333591
costamere
cellular_component
Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix.
GOC:mtg_muscle
http://purl.org/obo/owl/GOC#GOC_mtg_muscle
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
PMID:6405378
http://purl.org/obo/owl/PMID#PMID_6405378
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
Wikipedia:Costamere
http://purl.org/obo/owl/Wikipedia#Wikipedia_Costamere
starch grain
cellular_component
Plant storage body for amylose and amylopectin, 1-100um in diameter. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped.
PMID:11217978
http://purl.org/obo/owl/PMID#PMID_11217978
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
starch granule
germ cell nucleus
cellular_component
germ-cell nucleus
The nucleus of a germ cell, a reproductive cell in multicellular organisms.
CL:0000586
http://purl.org/obo/owl/CL#CL_0000586
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
sperm cell nucleus (sensu Magnoliophyta)
This term was made obsolete because the definition was incorrect.
cellular_component
OBSOLETE. The nucleus of a plant pollen cell, the male gamete, and its descendents.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
pollen germ cell nucleus
pollen germ-cell nucleus
megasporocyte nucleus
cellular_component
megaspore mother cell nucleus
The nucleus of a megasporocyte, a diploid cell that undergoes meiosis to produce four megaspores, and its descendents.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
ISBN:0618254153
http://purl.org/obo/owl/ISBN#ISBN_0618254153
polar nucleus
cellular_component
Either of two nuclei located centrally in a flowering plant embryo sac that eventually fuse to form the endosperm nucleus.
ISBN:0618254153
http://purl.org/obo/owl/ISBN#ISBN_0618254153
antipodal cell nucleus
cellular_component
The nucleus of an antipodal cell, one of three cells of the embryo sac in angiosperms, found at the chalazal end of the embryo away from the point of entry of the pollen tube, and its descendents.
CL:0000537
http://purl.org/obo/owl/CL#CL_0000537
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
megagametophyte egg cell nucleus
cellular_component
The nucleus of a plant egg cell. This nucleus is found at the micropylar end of the embryo.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
synaptic cleft
cellular_component
The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released.
URL:http://synapses.mcg.edu/anatomy/chemical/synapse.stm
http://synapses.mcg.edu/anatomy/chemical/synapse.stm
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
NIF_Subcellular:sao243541954
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao243541954
acrosomal matrix
cellular_component
A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction.
PMID:9139729
http://purl.org/obo/owl/PMID#PMID_9139729
PMID:8949900
http://purl.org/obo/owl/PMID#PMID_8949900
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
acrosomal lumen
cellular_component
The volume enclosed within the acrosome membrane.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
P granule
cellular_component
GO:0018994
germline granule
polar granule
nuage
A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
PMID:11262230
http://purl.org/obo/owl/PMID#PMID_11262230
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
cell septum surface
cellular_component
septum surface
The extracellular (rather than the intracellular) exterior of a dividing septum; this surface is usually composed of cell wall material, for example, lineal (1,3)-beta-D-glucan in S. pombe.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
cell septum edging
cellular_component
The cell wall material that surrounds the septum in fungal cells.
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
H4/H2A histone acetyltransferase complex
cellular_component
A multisubunit complex that catalyzes the acetylation of histones H4 and H2A.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
H4/H2A HAT complex
ATP-binding cassette (ABC) transporter complex
GO:0043191
cellular_component
GO:0043192
A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:11421269
http://purl.org/obo/owl/PMID#PMID_11421269
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:15111107
http://purl.org/obo/owl/PMID#PMID_15111107
ABC-type efflux permease complex
ABC-type efflux porter complex
ABC-type uptake permease complex
mating pheromone exporter
ATP-binding cassette (ABC) transporter complex
initial segment
cellular_component
NIF_Subcellular:sao256000789
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao256000789
Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment.
GOC:nln
http://purl.org/obo/owl/GOC#GOC_nln
terminal button
cellular_component
bouton
presynaptic bouton
synaptic bouton
terminal bouton
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
GOC:nln
http://purl.org/obo/owl/GOC#GOC_nln
varicosity
cellular_component
Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters.
GOC:nln
http://purl.org/obo/owl/GOC#GOC_nln
dendritic spine
cellular_component
Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity.
GOC:nln
http://purl.org/obo/owl/GOC#GOC_nln
NIF_Subcellular:sao1799103720
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1799103720
dendrite spine
Wikipedia:Dendritic_spine
http://purl.org/obo/owl/Wikipedia#Wikipedia_Dendritic_spine
dendritic shaft
cellular_component
NIF_Subcellular:sao2034472720
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao2034472720
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
GOC:nln
http://purl.org/obo/owl/GOC#GOC_nln
lysosomal lumen
cellular_component
The volume enclosed within the lysosomal membrane.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:15213228
http://purl.org/obo/owl/PMID#PMID_15213228
axon hillock
cellular_component
Portion of the neuronal cell soma from which the axon originates.
GOC:nln
http://purl.org/obo/owl/GOC#GOC_nln
NIF_Subcellular:sao627227260
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao627227260
Wikipedia:Axon_hillock
http://purl.org/obo/owl/Wikipedia#Wikipedia_Axon_hillock
perikaryon
cellular_component
The portion of the cell soma (cell body) that excludes the nucleus.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
cell soma cytoplasm
fibril
cellular_component
Extracellular matrix material consisting of polysaccharides and protein.
PMID:12704238
http://purl.org/obo/owl/PMID#PMID_12704238
myelin sheath
cellular_component
Schwann Cell Myelin Sheath
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
NIF_Subcellular:sao-593830697
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao-593830697
Wikipedia:Myelin
http://purl.org/obo/owl/Wikipedia#Wikipedia_Myelin
Wikipedia:Myelin
http://purl.org/obo/owl/Wikipedia#Wikipedia_Myelin
NIF_Subcellular:sao-593830697
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao-593830697
compact myelin
cellular_component
Schwann Cell Compact Myelin
The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs.
NIF_Subcellular:sao-1123256993
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao-1123256993
GOC:dgh
http://purl.org/obo/owl/GOC#GOC_dgh
NIF_Subcellular:sao-1123256993
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao-1123256993
lateral loop
cellular_component
Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode.
GOC:dgh
http://purl.org/obo/owl/GOC#GOC_dgh
Schmidt-Lanterman incisure
cellular_component
GO:0044287
NIF_Subcellular:sao254777664
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao254777664
Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier.
GOC:dgh
http://purl.org/obo/owl/GOC#GOC_dgh
Schmidt-Lanterman cleft
cytoplasmic SCF ubiquitin ligase complex
cellular_component
A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
PMID:15571813
http://purl.org/obo/owl/PMID#PMID_15571813
PMID:15688063
http://purl.org/obo/owl/PMID#PMID_15688063
cytoplasmic SCF complex
cytoplasmic cullin complex
cytoplasmic Skp1/Cul1/F-box protein complex
nuclear SCF ubiquitin ligase complex
cellular_component
nuclear cullin complex
A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
PMID:15571813
http://purl.org/obo/owl/PMID#PMID_15571813
PMID:15688063
http://purl.org/obo/owl/PMID#PMID_15688063
nuclear SCF complex
nuclear Skp1/Cul1/F-box protein complex
organelle
cellular_component
Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
NIF_Subcellular:sao1539965131
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1539965131
Wikipedia:Organelle
http://purl.org/obo/owl/Wikipedia#Wikipedia_Organelle
membrane-bounded organelle
cellular_component
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
membrane-enclosed organelle
NIF_Subcellular:sao414196390
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao414196390
non-membrane-bounded organelle
cellular_component
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
NIF_Subcellular:sao1456184038
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1456184038
non-membrane-enclosed organelle
intracellular organelle
cellular_component
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
extracellular organelle
cellular_component
Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:9914479
http://purl.org/obo/owl/PMID#PMID_9914479
intracellular membrane-bounded organelle
cellular_component
intracellular membrane-enclosed organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
intracellular non-membrane-bounded organelle
cellular_component
intracellular non-membrane-enclosed organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
organelle lumen
cellular_component
The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
protein complex
cellular_component
Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
Wikipedia:Protein_complex
http://purl.org/obo/owl/Wikipedia#Wikipedia_Protein_complex
protein-protein complex
receptor complex
cellular_component
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
Fanconi anaemia nuclear complex
cellular_component
FA complex
A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:12093742
http://purl.org/obo/owl/PMID#PMID_12093742
FA core complex
FA nuclear complex
Fanconi anaemia complex
extraorganismal space
cellular_component
The environmental space outside of an organism; this may be a host organism in the case of parasitic and symbiotic organisms.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
megasome
cellular_component
Large, cysteine proteinase rich lysosomes, often found in the amastigote (an intracytoplasmic, nonflagellated form of the parasite) stage of Leishmania species belonging to the mexicana complex.
PMID:11206117
http://purl.org/obo/owl/PMID#PMID_11206117
PMID:1999020
http://purl.org/obo/owl/PMID#PMID_1999020
chloroplast ribosome
cellular_component
A ribosome contained within a chloroplast.
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
laminin complex
cellular_component
A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes.
URL:http://www.sdbonline.org/fly/newgene/laminna1.htm
http://www.sdbonline.org/fly/newgene/laminna1.htm
PMID:10842354
http://purl.org/obo/owl/PMID#PMID_10842354
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
laminin-8 complex
cellular_component
A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains.
PMID:10842354
http://purl.org/obo/owl/PMID#PMID_10842354
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
laminin-9 complex
cellular_component
A laminin complex composed of alpha4, beta2 and gamma1 polypeptide chains.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:10842354
http://purl.org/obo/owl/PMID#PMID_10842354
laminin-10 complex
cellular_component
A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains.
PMID:10842354
http://purl.org/obo/owl/PMID#PMID_10842354
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
laminin-11 complex
cellular_component
A laminin complex composed of alpha5, beta2 and gamma1 polypeptide chains.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:10842354
http://purl.org/obo/owl/PMID#PMID_10842354
laminin-12 complex
cellular_component
A laminin complex composed of alpha2, beta1 and gamma3 polypeptide chains.
PMID:10842354
http://purl.org/obo/owl/PMID#PMID_10842354
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
cellulosome
cellular_component
Wikipedia:Cellulosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Cellulosome
An extracellular multi-enzyme complex containing up to 11 different enzymes aligned on a non-catalytic scaffolding glycoprotein. Functions to hydrolyze cellulose.
PMID:11601609
http://purl.org/obo/owl/PMID#PMID_11601609
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
extracellular non-membrane-bounded organelle
cellular_component
extracellular non-membrane-enclosed organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
ectoplasm
cellular_component
Granule free cytoplasm, lying immediately below the plasma membrane.
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
PMID:12211103
http://purl.org/obo/owl/PMID#PMID_12211103
RAVE complex
cellular_component
A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme.
PMID:11844802
http://purl.org/obo/owl/PMID#PMID_11844802
PMID:11283612
http://purl.org/obo/owl/PMID#PMID_11283612
regulator of the (H+)-ATPase of the vacuolar and endosomal membranes
contractile fiber
cellular_component
Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
contractile fibre
muscle fibre
muscle fiber
apoptosome
cellular_component
A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms.
PMID:12176339
http://purl.org/obo/owl/PMID#PMID_12176339
PMID:15189137
http://purl.org/obo/owl/PMID#PMID_15189137
PMID:10428850
http://purl.org/obo/owl/PMID#PMID_10428850
PMID:11406413
http://purl.org/obo/owl/PMID#PMID_11406413
GOC:mtg_apoptosis
http://purl.org/obo/owl/GOC#GOC_mtg_apoptosis
Wikipedia:Apoptosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Apoptosome
mitochondrial glutamate synthase complex (NADH)
cellular_component
A protein complex, found in the mitochondria, that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity.
PMID:7047525
http://purl.org/obo/owl/PMID#PMID_7047525
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
apical junction complex
cellular_component
apical cell junction complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
PMID:12525486
http://purl.org/obo/owl/PMID#PMID_12525486
PMID:15196556
http://purl.org/obo/owl/PMID#PMID_15196556
mating projection tip
cellular_component
shmoo tip
conjugation tube tip
The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
pre-T cell receptor complex
cellular_component
pre-T-lymphocyte receptor complex
A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins.
PMID:12220932
http://purl.org/obo/owl/PMID#PMID_12220932
ISBN:0781735149
http://purl.org/obo/owl/ISBN#ISBN_0781735149
pre-TCR complex
pre-T lymphocyte receptor complex
pre-T-cell receptor complex
phage terminase complex
cellular_component
A complex of a large and small subunit which catalyze the packaging of DNA into phage heads. Note that not all phage terminases have this structure, some exist as single polypeptides.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
CLRC ubiquitin ligase complex
cellular_component
CLRC complex
Clr4-Rik1-Cul4 complex
An active cullin-dependent E3 ubiquitin ligase complex essential for heterochromatin assembly by RNAi and histone H3K9 methylation.
PMID:20211136
http://purl.org/obo/owl/PMID#PMID_20211136
PMID:16127433
http://purl.org/obo/owl/PMID#PMID_16127433
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
Rik1-E3 ubiquitin ligase complex
Rik1 E3 ubiquitin ligase complex
centromere-specific nucleosome
cellular_component
centromeric nucleosome
centromere specific nucleosome
A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3).
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
PMID:15175412
http://purl.org/obo/owl/PMID#PMID_15175412
PMID:16183641
http://purl.org/obo/owl/PMID#PMID_16183641
activin A complex
Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and an inhibin alpha subunit. See also the cellular component term 'inhibin complex ; GO:0043511'.
GO:0048181
cellular_component
A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A).
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
activin B complex
Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'.
cellular_component
GO:0048182
A nonsteroidal regulator, composed of two covalently linked inhibin beta-B subunits (sometimes known as activin beta-B or activin/inhibin beta-B).
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
inhibin complex
Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'.
cellular_component
Heterodimeric hormone composed of an inhibin alpha subunit complexed with either an inhibin beta-A subunit, to form inhibin A, or an inhibin beta-B subunit, to form inhibin B.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
inhibin A complex
Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'.
cellular_component
Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-A subunit.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
inhibin B complex
Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'.
cellular_component
Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-B subunit.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
interleukin-12 complex
Note that this heterodimeric cytokine utilizes the IL-12p35 subunit as its alpha chain, which is also used by IL-35 as its alpha chain, and utilizes the IL-12p40 subunit as its beta chain, which is also used by IL-23 as its beta chain.
cellular_component
IL12B
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IL12A
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
p35
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IL-12 complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
p40
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space.
PMID:1381512
http://purl.org/obo/owl/PMID#PMID_1381512
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
GOC:ebc
http://purl.org/obo/owl/GOC#GOC_ebc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:12948519
http://purl.org/obo/owl/PMID#PMID_12948519
tRNA methyltransferase complex
cellular_component
A multimeric protein complex involved in the methylation of specific nucleotides in tRNA.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
tRNA (m2G10) methyltransferase complex
cellular_component
A protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p.
PMID:15899842
http://purl.org/obo/owl/PMID#PMID_15899842
GET complex
cellular_component
A multisubunit complex involved in ER/Golgi trafficking (Golgi to ER Traffic). In yeast, includes Get1p, Get2p and Get3p proteins.
PMID:16269340
http://purl.org/obo/owl/PMID#PMID_16269340
Golgi to ER Traffic complex
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex
cellular_component
A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis.
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
UDP-N-acetylglucosamine transferase complex
See also the molecular function term 'N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity ; GO:0004577'.
cellular_component
A multienzyme, heterooligomeric complex involved in dolichyl-linked oligosaccharide synthesis. In yeast the complex is composed of Alg7p, which catalyzes the first step (GlcNAc1-PP-Dol from dolichol-phosphate and UDP-GlcNAc), and Alg13p plus Alg14p, the catalytic and anchoring subunits respectively, which together catalyze the second step (GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc) of dolichyl-linked oligosaccharide synthesis.
GOC:rn
http://purl.org/obo/owl/GOC#GOC_rn
PMID:19129246
http://purl.org/obo/owl/PMID#PMID_19129246
Ku70:Ku80 complex
cellular_component
Ku70:Ku80 heterodimer
Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK.
PMID:12518983
http://purl.org/obo/owl/PMID#PMID_12518983
bacterial nucleoid
cellular_component
The region of a bacterial cell to which the DNA is confined.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
endospore external encapsulating structure
GO:0055030
cellular_component
peptidoglycan-based spore wall
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
endospore wall
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
spore wall
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
The structures that lie outside the inner membrane and surround the entire endospore; consists of a peptidoglycan-containing inner layer (the endospore cortex) surrounded by a multilayered proteinaceous coat. An exosporium may be present as an extreme outer layer.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
PMID:15035041
http://purl.org/obo/owl/PMID#PMID_15035041
exosporium
cellular_component
The outermost layer of a bacterial endospore, which is loosely attached and located outside of the endospore coat. It is generally composed of protein, carbohydrate, and perhaps lipid.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
perispore
epispore
exospore
endospore coat
cellular_component
The layer in a bacterial endospore that lies under the exosporium, and is impermeable to many toxic molecules. The coat may also contain enzymes that are involved in endospore germination.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
outer endospore membrane
cellular_component
The outer membrane around a bacterial endospore, located between the endospore cortex and endospore coat.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
endospore cortex
cellular_component
A layer surrounding a bacterial endospore found inside the outer endospore membrane, but outside the membrane surrounding the endospore core. It consists of peptidoglycan of a different chemical nature than that found in vegetative cell walls which results in less cross-linking of peptidoglycan.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
nuclear replication fork
cellular_component
The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
cytoplasmic replication fork
cellular_component
The Y-shaped region of a cytoplasmic replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
cytoplasmic DNA replication factor C complex
cellular_component
A cytoplasmic complex of two polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. Examples of this component are found in prokaryotic species.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:14646196
http://purl.org/obo/owl/PMID#PMID_14646196
PMID:16172520
http://purl.org/obo/owl/PMID#PMID_16172520
nuclear DNA replication factor C complex
cellular_component
A nuclear complex of five polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase delta or epsilon. In Saccharomyces and several other species, the subunits are known as Rfc1p-Rfc5p, although subunit names do not necessarily correspond between different species.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:14614842
http://purl.org/obo/owl/PMID#PMID_14614842
cytoplasmic replisome
cellular_component
A multi-component enzymatic machine at the cytoplasmic replication fork, which mediates DNA replication. Includes DNA primase, DNA polymerase, DNA helicase, and other proteins.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
nuclear replisome
cellular_component
A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
multi-eIF complex
cellular_component
multifactor translation initiation factor (eIF) complex
A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
delta DNA polymerase complex
GO:0005659
cellular_component
A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
PMID:11205330
http://purl.org/obo/owl/PMID#PMID_11205330
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:12403614
http://purl.org/obo/owl/PMID#PMID_12403614
delta-DNA polymerase complex
PCNA complex
cellular_component
A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:12829735
http://purl.org/obo/owl/PMID#PMID_12829735
proliferating cell nuclear antigen complex
PCNA homotrimer
sliding clamp
extracellular space of host
cellular_component
The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream.
GOC:cc
http://purl.org/obo/owl/GOC#GOC_cc
host extracellular space
intracellular region of host
cellular_component
That space within the plasma membrane of a host cell.
GOC:cc
http://purl.org/obo/owl/GOC#GOC_cc
host intracellular
host cell
cellular_component
A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host symbiosome
cellular_component
A double-enveloped cell compartment, composed of the endosymbiont with its plasmalemma (as inner envelope) and an outer envelope (the perisymbiontic membrane) derived from the host cell.
GOC:cc
http://purl.org/obo/owl/GOC#GOC_cc
symbiosome
cellular_component
A double-enveloped cell compartment, composed of an endosymbiont with its plasmalemma (as inner envelope) and a non-endosymbiotic outer envelope (the perisymbiontic membrane).
GOC:cc
http://purl.org/obo/owl/GOC#GOC_cc
bacteroid-containing symbiosome
cellular_component
A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants.
GOC:cc
http://purl.org/obo/owl/GOC#GOC_cc
peribacteroid membrane
cellular_component
A membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells).
GOC:cc
http://purl.org/obo/owl/GOC#GOC_cc
peribacteroid fluid
cellular_component
The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome.
GOC:cc
http://purl.org/obo/owl/GOC#GOC_cc
host bacteroid-containing symbiosome
cellular_component
A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants, of a host cell.
GOC:cc
http://purl.org/obo/owl/GOC#GOC_cc
host peribacteroid membrane
cellular_component
A host-derived membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells).
GOC:cc
http://purl.org/obo/owl/GOC#GOC_cc
host peribacteroid fluid
cellular_component
The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome of a host cell.
GOC:cc
http://purl.org/obo/owl/GOC#GOC_cc
pollen wall
Note that this term is a child of 'extracellular matrix part ; GO:0044420' rather than the more specific middle lamella-containing extracellular matrix ; GO:0048196', because unlike the usual plant cell wall, the pollen wall does not contain a middle lamella, as specified in the definition of 'middle lamella-containing extracellular matrix ; GO:0048196'.
cellular_component
The complex wall surrounding a pollen grain.
GOC:fz
http://purl.org/obo/owl/GOC#GOC_fz
microspore wall
exine
Note that the exine is highly resistant to strong acids and bases.
cellular_component
The outer layer of the pollen grain wall which is composed primarily of sporopollenin.
URL:http://www.mobot.org/MOBOT/research/APweb/
http://www.mobot.org/MOBOT/research/APweb/
ectexine
Note that ectexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'endexine ; GO:0043671'.
cellular_component
The outer part of the exine, which stains positively with basic fuchsin in optical microscopy and has higher electron density in conventionally prepared TEM sections.
URL:http://www.mobot.org/MOBOT/research/APweb/
http://www.mobot.org/MOBOT/research/APweb/
foot layer
cellular_component
nexine 1
The inner layer of the ectexine.
URL:http://www.mobot.org/MOBOT/research/APweb/
http://www.mobot.org/MOBOT/research/APweb/
endexine
Note that endexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'ectexine ; GO:0043669'.
cellular_component
The inner part of the exine, which stains.
URL:http://www.mobot.org/MOBOT/research/APweb/
http://www.mobot.org/MOBOT/research/APweb/
nexine
Note that nexine is distinguished on purely morphological criteria; compare with 'endexine ; GO:0043671'. See also 'sexine ; GO:0043673'.
cellular_component
The inner, non-sculptured part of the exine which lies below the sexine.
URL:http://www.mobot.org/MOBOT/research/APweb/
http://www.mobot.org/MOBOT/research/APweb/
sexine
Note that the sexine sometimes consists of 5 layers, but of those, 3 layers are the most common (sexine 1 = columellae; sexine 2 = tectum; sexine 3 = sculpture elements). Sexine is distinguished on purely morphological criteria; compare with 'ectexine ; GO:0043669'. See also 'nexine ; GO:0043672'.
cellular_component
The outer, sculptured layer of the exine, which lies above the nexine.
URL:http://www.mobot.org/MOBOT/research/APweb/
http://www.mobot.org/MOBOT/research/APweb/
columella
cellular_component
sexine 1
A rod-like element of the sexine and ectexine, supporting either the tectum (the layer of sexine which forms a roof over the columella), or supporting a caput (an architectural element on top of a columella).
URL:http://www.mobot.org/MOBOT/research/APweb/
http://www.mobot.org/MOBOT/research/APweb/
sculpture element
cellular_component
The third layer of the sexine.
URL:http://www.mobot.org/MOBOT/research/APweb/
http://www.mobot.org/MOBOT/research/APweb/
tectum
cellular_component
The layer of sexine which forms a roof over the columella, granules or other infratectal elements.
URL:http://www.mobot.org/MOBOT/research/APweb/
http://www.mobot.org/MOBOT/research/APweb/
sexine 2
germination pore
cellular_component
germ pore
A small pore in the outer wall of a mycelial spore through which the germ tube exits upon germination. It can be apical or eccentric in its location.
Wikipedia:Germ_pore
http://purl.org/obo/owl/Wikipedia#Wikipedia_Germ_pore
Wikipedia:Germ_pore
http://purl.org/obo/owl/Wikipedia#Wikipedia_Germ_pore
intine
Note that the intine is not acetolysis resistant and is therefore absent in conventionally prepared palynological material.
cellular_component
The innermost of the major layers of the pollen grain wall which underlies the exine and borders the cytoplasm.
URL:http://www.mobot.org/MOBOT/research/APweb/
http://www.mobot.org/MOBOT/research/APweb/
axon terminus
cellular_component
axon terminal
axon terminal specialization
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
nerve ending
filiform apparatus
cellular_component
A complex of cell wall invaginations in a synergid cell, similar to those in transfer cells.
ISBN:0471245208
http://purl.org/obo/owl/ISBN#ISBN_0471245208
type IV secretion system complex
cellular_component
type IV protein secretion system complex
A complex of proteins related to those involved in bacterial DNA conjugative transfer, that permits the transfer of DNA or proteins into the extracellular milieu or directly into host cells. In general the type IV complex forms a multisubunit cell-envelope-spanning structure composed of a secretion channel and often a pilus or other surface filament or protein(s).
GOC:ml
http://purl.org/obo/owl/GOC#GOC_ml
T4SS complex
iridosome
cellular_component
reflecting platelet
A tissue-specific, membrane-bounded cytoplasmic organelle within which purines crystalize in reflective stacks. Iridosomes are synthesized in iridophore cells and are silver, gold or iridescent in appearance.
GOC:mh
http://purl.org/obo/owl/GOC#GOC_mh
leucosome
cellular_component
refractosome
A tissue-specific, membrane-bounded cytoplasmic organelle within which uric acid and/or purines crystalize in reflective stacks. Leucosomes are synthesized in leucophore cells and have a whitish cast.
GOC:mh
http://purl.org/obo/owl/GOC#GOC_mh
pterinosome
cellular_component
A tissue-specific, membrane-bounded cytoplasmic organelle within which pteridine pigments are synthesized and stored. Pterinosomes are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance.
GOC:mh
http://purl.org/obo/owl/GOC#GOC_mh
cyanosome
cellular_component
A tissue-specific, membrane-bounded cytoplasmic organelle within which an unknown blue pigment is localized. Cyanosomes are synthesized in cyanophores and are blue in appearance.
GOC:mh
http://purl.org/obo/owl/GOC#GOC_mh
carotenoid vesicle
cellular_component
A tissue-specific cytoplasmic vesicle surrounded by a membrane half-leaflet within which carotenoid pigments are stored. Carotenoid vescicles are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance.
GOC:mh
http://purl.org/obo/owl/GOC#GOC_mh
Tpg-containing telomere binding complex
cellular_component
A complex composed of four polypeptides, a telomere-protecting terminal protein (Tpg), a telomere-associated protein (Tap), DNA polymerase (PolA) and topoisomerase I (TopA), that functions in the replication of the telomeric regions of linear chromosomes, plasmids and circular replicons of some bacterial species.
PMID:15353591
http://purl.org/obo/owl/PMID#PMID_15353591
telomere complex
DNA polymerase III, proofreading complex
cellular_component
A subcomplex of DNA polymerase III composed of the epsilon subunit which has proofreading activity, and the theta subunit which enhances the epsilon subunit's proofreading activity.
IMG:01721
http://purl.org/obo/owl/IMG#IMG_01721
PMID:16973612
http://purl.org/obo/owl/PMID#PMID_16973612
Wikipedia:Pol_III
http://purl.org/obo/owl/Wikipedia#Wikipedia_Pol_III
DNA polymerase III, proof-reading complex
DNA polymerase III, proofreading subcomplex
DNA polymerase III, proof-reading subcomplex
DNA polymerase III, DnaX complex
cellular_component
A heptamer that includes the tau and gamma products of the dnaX gene and the chi/psi subcomplex. Confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands.
PMID:12940977
http://purl.org/obo/owl/PMID#PMID_12940977
clamp loader complex
DNA polymerase III, clamp loader complex
DNA polymerase III, DnaX subcomplex
DNA polymerase III, DnaX complex, chi/psi subcomplex
cellular_component
A dimer composed of the chi and psi subunits which is a subassembly of the DNA polymerase III DnaX complex and serves as a bridge between the DnaX complex and the single-stranded DNA-binding protein (SSB).
IMG:01719
http://purl.org/obo/owl/IMG#IMG_01719
PMID:12940977
http://purl.org/obo/owl/PMID#PMID_12940977
DNA polymerase III, clamp loader chi/psi subcomplex
RecFOR complex
cellular_component
A heterotrimeric complex composed of the subunits RecF, RecO and RecR. Mediates the loading of RecA protein specifically onto SSB-coated gapped DNA during DNA repair.
PMID:12769856
http://purl.org/obo/owl/PMID#PMID_12769856
IMG:01764
http://purl.org/obo/owl/IMG#IMG_01764
methanol-CoM methyltransferase complex
cellular_component
methanol-coenzyme M methyltransferase complex
MetaCyc:CPLX-421
http://purl.org/obo/owl/MetaCyc#MetaCyc_CPLX-421
methanol: coenzyme M methyltransferase complex
methanol: CoM methyltransferase complex
A heterotrimeric protein complex composed of a methanol methyltransferase subunit, a corrinoid protein and a methanol-specific corrinoid:coenzyme M methyltransferase subunit. Catalyzes the transfer of a methyl group from methanol to coenzyme M as part of the pathway of methanogenesis from methanol.
IMG:01437
http://purl.org/obo/owl/IMG#IMG_01437
MetaCyc:CPLX-421
http://purl.org/obo/owl/MetaCyc#MetaCyc_CPLX-421
PMID:9363780
http://purl.org/obo/owl/PMID#PMID_9363780
methanol:coenzyme M methyltransferase complex
methanol:CoM methyltransferase complex
chromosome segregation-directing complex
cellular_component
IMG:02994
http://purl.org/obo/owl/IMG#IMG_02994
longitudinal peptidoglycan synthesis-directing complex
A trimeric protein complex which in E. coli is composed of the subunits MreB, MreC and MreD. The complex directs longitudinal cell wall synthesis, maintaining cell morphology.
PMID:15612918
http://purl.org/obo/owl/PMID#PMID_15612918
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
MreBCD complex
chromosome segregation directing complex
host cell membrane pore complex
cellular_component
pore complex in host cell membrane
Any small opening in a host cell membrane that allows the passage of gases and/or liquids, composed of host proteins.
MITRE:tk
http://purl.org/obo/owl/MITRE#MITRE_tk
host cell nuclear part
cellular_component
Any constituent part of a host cell's nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. The host is the larger of the organisms involved in a symbiotic interaction.
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
host cell nucleoplasm
cellular_component
That part of a host cell's nuclear content other than the chromosomes or the nucleolus. The host is the larger of the organisms involved in a symbiotic interaction.
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
type IV pilus
cellular_component
type 4 pilus
TFP
type IV fimbriae
A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
polar tube
cellular_component
A highly specialized structure unique to microsporidia that is required for host cell invasion. In the spore, the polar tube is connected at the anterior end, and then coils around the sporoplasm. Upon appropriate environmental stimulation, the polar tube rapidly discharges out of the spore, pierces a cell membrane and serves as a conduit for sporoplasm passage into the new host cell.
GOC:mf
http://purl.org/obo/owl/GOC#GOC_mf
PMID:9723921
http://purl.org/obo/owl/PMID#PMID_9723921
PMID:12076771
http://purl.org/obo/owl/PMID#PMID_12076771
sporoplasm
cellular_component
The complex infective apparatus corresponding to the central mass of cytoplasm within a spore that is injected into a host cell by various parasitic microorganisms.
GOC:mf
http://purl.org/obo/owl/GOC#GOC_mf
PMID:12076771
http://purl.org/obo/owl/PMID#PMID_12076771
PMID:16004371
http://purl.org/obo/owl/PMID#PMID_16004371
PMID:9723921
http://purl.org/obo/owl/PMID#PMID_9723921
host caveola
cellular_component
A small pit, depression, or invagination, such as any of the minute pits or incuppings of the host cell membrane formed during pinocytosis, that communicates with the outside of a host cell and extends inward, indenting the host cytoplasm and the host cell membrane. Such caveolae may be pinched off to form free vesicles within the host cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
host cell junction
cellular_component
A plasma membrane part that forms a specialized region of connection between two host cells or between a host cell and the host extracellular matrix. At a host cell junction, anchoring proteins extend through the host plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
host cell projection
cellular_component
A prolongation or process extending from a host cell, e.g. a flagellum or axon.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
host cell wall
cellular_component
The rigid or semi-rigid envelope lying outside the host cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
host thylakoid
cellular_component
A membranous cellular structure within the host cell that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the host plasma membrane. In eukaryotic host cells they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
host thylakoid membrane
cellular_component
The pigmented membrane of any host thylakoid.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
host cell cytoplasmic vesicle
cellular_component
A vesicle formed of membrane or protein, found in the cytoplasm of a host cell.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
host cell cytoplasmic vesicle membrane
cellular_component
The lipid bilayer surrounding a host cell cytoplasmic vesicle.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
host cytoskeleton
cellular_component
Any of the various filamentous elements that form the internal framework of host cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the host cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the host cell. The various elements of the host cytoskeleton not only serve in the maintenance of host cellular shape but also have roles in other host cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
host cell cytosol
cellular_component
The part of the host cell cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cytosol
host cell endoplasmic reticulum
cellular_component
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host endoplasmic reticulum
host cell endoplasmic reticulum lumen
cellular_component
host endoplasmic reticulum lumen
The volume enclosed by the membranes of the host cell endoplasmic reticulum.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell endoplasmic reticulum membrane
cellular_component
host endoplasmic reticulum membrane
The lipid bilayer surrounding the host cell endoplasmic reticulum.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell rough endoplasmic reticulum
cellular_component
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host rough ER has ribosomes adhering to the outer surface.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host rough endoplasmic reticulum
host cell rough endoplasmic reticulum membrane
cellular_component
The lipid bilayer surrounding the host cell rough endoplasmic reticulum.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host rough endoplasmic reticulum membrane
host cell smooth endoplasmic reticulum
cellular_component
host smooth endoplasmic reticulum
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host smooth ER has no ribosomes adhering to the outer surface.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell smooth endoplasmic reticulum membrane
cellular_component
The lipid bilayer surrounding the host cell smooth endoplasmic reticulum.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host smooth endoplasmic reticulum membrane
host cell endoplasmic reticulum-Golgi intermediate compartment
cellular_component
host cell ER-Golgi intermediate compartment
A complex system of membrane-bounded compartments located between host cell endoplasmic reticulum (ER) and the host Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
GOC:pr
http://purl.org/obo/owl/GOC#GOC_pr
host ER-Golgi intermediate compartment
host cell endoplasmic reticulum-Golgi intermediate compartment membrane
cellular_component
The lipid bilayer surrounding any of the compartments of the host cell ER-Golgi intermediate compartment system.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell ER-Golgi intermediate compartment membrane
host endoplasmic reticulum-Golgi intermediate compartment membrane
host ER-Golgi intermediate compartment membrane
host cell endosome
cellular_component
A membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to host cell lysosomes for degradation.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host endosome
host cell endosome membrane
cellular_component
host endosome membrane
The lipid bilayer surrounding a host cell endosome.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell filopodium
cellular_component
host filopodium
Thin, stiff protrusion extended by the leading edge of a motile host cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell Golgi apparatus
cellular_component
host Golgi apparatus
A compound membranous cytoplasmic organelle of eukaryotic host cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell Golgi membrane
cellular_component
The lipid bilayer surrounding any of the compartments of the host cell Golgi apparatus.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host Golgi membrane
host cell late endosome
cellular_component
A prelysosomal endocytic organelle differentiated from host early endosomes by lower lumenal pH and different protein composition. Host late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell late endosome membrane
cellular_component
The lipid bilayer surrounding a host cell late endosome.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell lipid particle
cellular_component
Any particle of coalesced lipids in the cytoplasm of a host cell. May include associated proteins.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell lysosome
cellular_component
A small lytic vacuole that has cell cycle-independent morphology and is found in most host animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and host cell lysosomes have a great variety of morphologies and functions.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell lysosomal membrane
cellular_component
The lipid bilayer surrounding the host cell lysosome and separating its contents from the host cell cytoplasm.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell microsome
cellular_component
Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic host cells are homogenized and that sediment on centrifugation at 100000 g.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell microsomal membrane
host cell mitochondrial envelope
cellular_component
The double lipid bilayer enclosing the host cell mitochondrion and separating its contents from the host cell cytoplasm; includes the intermembrane space.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell mitochondrial membrane
cellular_component
Either of the lipid bilayers that surround the host cell mitochondrion and form the host cell mitochondrial envelope.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell mitochondrial inner membrane
cellular_component
The inner, i.e. lumen-facing, lipid bilayer of the host cell mitochondrial envelope. It is highly folded to form cristae.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell mitochondrial outer membrane
cellular_component
The outer, i.e. cytoplasm-facing, lipid bilayer of the host cell mitochondrial envelope.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
cytolytic granule
cellular_component
A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:11052265
http://purl.org/obo/owl/PMID#PMID_11052265
PMID:12766758
http://purl.org/obo/owl/PMID#PMID_12766758
nucleoplasmic reticulum
cellular_component
Long, dynamic tubular channels, formed by invagination of the nuclear envelope, that extend deep into the nucleoplasm. The channels have an underlying lamina and are implicated in functioning in signaling and transport.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:9024685
http://purl.org/obo/owl/PMID#PMID_9024685
PMID:17959832
http://purl.org/obo/owl/PMID#PMID_17959832
nuclear channels
host cell nucleolus
cellular_component
A small, dense body one or more of which are present in the nucleus of eukaryotic host cells.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell nuclear envelope
cellular_component
The double lipid bilayer enclosing the host nucleus and separating its contents from the rest of the host cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell nuclear membrane
cellular_component
Either of the lipid bilayers that surround the host nucleus and form the nuclear envelope; excludes the intermembrane space.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell nuclear inner membrane
cellular_component
The inner, i.e. lumen-facing, lipid bilayer of the host nuclear envelope.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell nuclear outer membrane
cellular_component
The outer, i.e. cytoplasm-facing, lipid bilayer of the host nuclear envelope; continuous with the endoplasmic reticulum of the host cell and sometimes studded with ribosomes.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell nuclear lamina
cellular_component
The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a host cell nucleus, composed of lamin filaments.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell nuclear matrix
cellular_component
The dense fibrillar network lying on the inner side of the host nuclear membrane.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
translation initiation ternary complex
cellular_component
A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
Met-tRNA/eIF2.GTP ternary complex
translation initiation (ternary) complex
fully spanning plasma membrane
cellular_component
Fully spanning both phospholipid bilayers of a plasma membrane.
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
transmembrane
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
other organism
cellular_component
A secondary organism with which the first organism is interacting.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
other organism cell
cellular_component
A cell of a secondary organism with which the first organism is interacting.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
other organism part
cellular_component
Any constituent part of a secondary organism with which the first organism is interacting.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
other organism cell membrane
cellular_component
The cell membrane of a secondary organism with which the first organism is interacting.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
foreign membrane
host cell plasmodesma
cellular_component
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one host cell to that of an adjacent host cell.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
host cell perinuclear region of cytoplasm
cellular_component
The host cell cytoplasm situated near, or occurring around, the host nucleus.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
host cell synapse
cellular_component
The junction between a nerve fiber of one host neuron and another host neuron or muscle fiber or glial cell; the site of interneuronal communication.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
anammoxosome
cellular_component
An intracytoplasmic membrane-bounded compartment in anaerobic ammonium oxidation (anammox) bacteria, is the site of anammox catabolism.
PMID:19682260
http://purl.org/obo/owl/PMID#PMID_19682260
PMID:17993524
http://purl.org/obo/owl/PMID#PMID_17993524
GOC:dh
http://purl.org/obo/owl/GOC#GOC_dh
pirellulosome
cellular_component
A cytoplasmic structure found in bacterial phyla Planctomycetes and Verrucomicrobia containing a condensed nucleoid and ribosomes and surrounded by an intracytoplasmic membrane. It is surrounded by ribosome-free cytoplasm, in a compartment called the paryphoplasm.
PMID:19133117
http://purl.org/obo/owl/PMID#PMID_19133117
GOC:dh
http://purl.org/obo/owl/GOC#GOC_dh
juxtaparanode region of axon
cellular_component
juxtaparanode
juxtaparanodal region
A region of an axon near a node of Ranvier that is between the paranode and internode regions.
PMID:10624965
http://purl.org/obo/owl/PMID#PMID_10624965
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
PMID:14682359
http://purl.org/obo/owl/PMID#PMID_14682359
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
NIF_Subcellular:sao758620702
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao758620702
apical pole of neuron
cellular_component
NIF_Subcellular:sao1186862860
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1186862860
Portion of a neuron cell soma closest to the point where the apical dendrite emerges.
NIF_Subcellular:sao1186862860
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1186862860
basal pole of neuron
cellular_component
Portion of a neuron cell soma closest to the point where the basilar dendrite emerges.
NIF_Subcellular:sao1186862860
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1186862860
NIF_Subcellular:sao1186862860
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1186862860
methane-oxidizing organelle
cellular_component
A cytoplasmic, membrane-bounded compartment found within Methanotrophic bacteria that contains enzymes and electron transfer proteins for methane catabolism. This structure is analogous to the thylakoid of Cyanobacteria and the anammoxosome of anaerobic ammonium oxidation organisms.
GOC:dh
http://purl.org/obo/owl/GOC#GOC_dh
methane-oxidizing compartment
methanotroph intracytoplasmic membrane-bound compartment
host cell surface
cellular_component
The external part of the host cell wall and/or host plasma membrane.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
host cell periplasmic space
cellular_component
The region between the inner (cytoplasmic) and outer host membrane (Gram-negative Bacteria) or inner host membrane and host cell wall (Fungi).
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
host cell envelope
cellular_component
An envelope that surrounds a bacterial host cell and includes the host cytoplasmic membrane and everything external, encompassing the host periplasmic space, host cell wall, and host outer membrane if present.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
host cell presynaptic membrane
cellular_component
A specialized area of membrane of the host axon terminal that faces the plasma membrane of the host neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many host synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
organelle membrane contact site
cellular_component
inter-organelle junction
interorganelle junction
MCS
A zone of apposition between the membranes of two organelles, structured by bridging complexes. Membrane contact sites (MCSs) are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions.
PMID:16806880
http://purl.org/obo/owl/PMID#PMID_16806880
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
ER-mitochondrion membrane contact site
cellular_component
A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:19556461
http://purl.org/obo/owl/PMID#PMID_19556461
endoplasmic-reticulum-mitochondrion membrane contact site
other organism membrane
cellular_component
A membrane of a secondary organism with which the first organism is interacting.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
subplasmalemmal coating
cellular_component
Electron dense material observed coating the cytoplasmic face of the plasma membrane in certain regions of a neuron, e.g., the axon initial segment; the nodal membrane at the Node of Ranvier.
NIF_Subcellular:sao1938587839
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1938587839
NIF_Subcellular:sao1938587839
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1938587839
mitochondrial crista junction
cellular_component
cristae junction
crista junction
NIF_Subcellular:sao1825845900
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1825845900
A tubular structure of relatively uniform size that connects a mitochondrial crista to the mitochondrial inner boundary membrane.
NIF_Subcellular:sao1825845900
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1825845900
PMID:21987634
http://purl.org/obo/owl/PMID#PMID_21987634
PMID:21944719
http://purl.org/obo/owl/PMID#PMID_21944719
PMID:22009199
http://purl.org/obo/owl/PMID#PMID_22009199
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
bridge contact site
cellular_component
Site of contact between the inner and outer mitochondrial membrane found in neuronal mitochondria; may play a role in maintaining the structural integrity of the inner and outer boundary membranes.
NIF_Subcellular:sao1858501007
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1858501007
NIF_Subcellular:sao1858501007
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1858501007
peg and socket contact
cellular_component
ball and socket contact
GOC:tfm
http://purl.org/obo/owl/GOC#GOC_tfm
PMID:17591898
http://purl.org/obo/owl/PMID#PMID_17591898
NIF_Subcellular:sao1943947957
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1943947957
A cell-cell contact zone that consists of membrane invaginations extending from either cell, which contain tight-, gap-, and adherens junctions. Peg and socket contacts form between endothelial cells and pericytes, and between lens fiber cells.
PMID:17591898
http://purl.org/obo/owl/PMID#PMID_17591898
PMID:16166562
http://purl.org/obo/owl/PMID#PMID_16166562
PMID:12883993
http://purl.org/obo/owl/PMID#PMID_12883993
NIF_Subcellular:sao1943947957
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1943947957
GOC:tfm
http://purl.org/obo/owl/GOC#GOC_tfm
puncta adhaerentia
cellular_component
A small version of the zonula adherens type junction, characterized by a symmetrical adherent point between two cells.
NIF_Subcellular:sao257629430
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao257629430
NIF_Subcellular:sao257629430
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao257629430
contact site
cellular_component
NIF_Subcellular:sao447856407
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao447856407
Sites of close apposition of the inner and outer mitochondrial membrane.
NIF_Subcellular:sao447856407
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao447856407
mitochondrial intracristal space
cellular_component
NIF_Subcellular:sao508958414
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao508958414
The space bounded by the mitochondrial cristae membranes, continuous with the intermembrane space.
NIF_Subcellular:sao508958414
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao508958414
cell-cell contact zone
cellular_component
cell cell contact zone
Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle.
NIF_Subcellular:sao1299635018
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1299635018
NIF_Subcellular:sao1299635018
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1299635018
dendrite terminus
cellular_component
terminal specialization of a dendrite
dendrite terminal specialization
dendrite terminal
NIF_Subcellular:sao28175134
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao28175134
A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole.
NIF_Subcellular:sao28175134
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao28175134
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
dendriole
cellular_component
Small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell (UBC).
NIF_Subcellular:sao28175134
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao28175134
PMID:8300904
http://purl.org/obo/owl/PMID#PMID_8300904
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
NIF_Subcellular:sao28175134
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao28175134
dendritic growth cone
cellular_component
dendrite growth cone
NIF_Subcellular:sao1594955670
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1594955670
The migrating motile tip of a growing nerve cell dendrite.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
axonal growth cone
cellular_component
NIF_Subcellular:sao1594955670
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1594955670
axon growth cone
The migrating motile tip of a growing nerve cell axon.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
dendritic tuft
cellular_component
dendrite tuft
NIF_Subcellular:sao1340260079
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1340260079
The terminal specialization found in some types of dendrites which consists of numerous small terminal branches, giving the dendrite a tufted appearance.
NIF_Subcellular:sao1340260079
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1340260079
cell body
Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.
cellular_component
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
cell soma
cell body membrane
cellular_component
The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections.
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
cell soma membrane
C-fiber
cellular_component
C-fibre
The axon of a dorsal root ganglion cell that are responsive to pain and temperature. C-fibers are small in diameter (0.2-1.5 um) and unmyelinated.
NIF_Subcellular:nlx_subcell_20090210
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_nlx_subcell_20090210
NIF_Subcellular:nlx_subcell_20090210
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_nlx_subcell_20090210
cerebellar mossy fiber
cellular_component
cerebellar mossy fibre
NIF_Subcellular:nlx_subcell_20090209
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_nlx_subcell_20090209
An axon arising from cerebellar projecting cells in the cochlea, vestibular nuclei, spinal cord, reticular formation, cerebellar nuclei and basilar pontine nuclei. Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons as "mossy" appearance in Golgi stained preparations.
NIF_Subcellular:nlx_subcell_20090209
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_nlx_subcell_20090209
climbing fiber
cellular_component
climbing fibre
NIF_Subcellular:nlx_subcell_20090203
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_nlx_subcell_20090203
The axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to "climb" along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber.
NIF_Subcellular:nlx_subcell_20090203
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_nlx_subcell_20090203
dentate gyrus mossy fiber
cellular_component
dentate gyrus mossy fibre
granule cell axon
NIF_Subcellular:nlx_subcell_20090601
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_nlx_subcell_20090601
Distinctive, unmyelinated axons produced by granule cells.
PMID:17765709
http://purl.org/obo/owl/PMID#PMID_17765709
NIF_Subcellular:nlx_subcell_20090601
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_nlx_subcell_20090601
axon collateral
cellular_component
NIF_Subcellular:sao1470140754
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1470140754
Any of the smaller branches of an axon that emanate from the main axon cylinder.
NIF_Subcellular:sao1470140754
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1470140754
main axon
cellular_component
NIF_Subcellular:sao1596975044
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1596975044
The main axonal trunk, as opposed to the collaterals.
NIF_Subcellular:sao1596975044
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1596975044
axon trunk
calyx of Held
cellular_component
NIF_Subcellular:sao1684283879
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1684283879
The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system.
PMID:11823805
http://purl.org/obo/owl/PMID#PMID_11823805
NIF_Subcellular:sao1684283879
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1684283879
neuron projection terminus
cellular_component
The specialized, terminal region of a neuron projection such as an axon or a dendrite.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
neuron projection terminal
neuron terminal specialization
dendritic branch
cellular_component
NIF_Subcellular:sao884265541
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao884265541
dendrite branch
A dendrite arising from another dendrite.
NIF_Subcellular:sao884265541
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao884265541
axonal spine
cellular_component
A spine that originates from the axon, usually from the initial segment.
NIF_Subcellular:sao18239917
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao18239917
NIF_Subcellular:sao18239917
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao18239917
axon spine
neuron spine
cellular_component
A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck.
ISBN:0198504888
http://purl.org/obo/owl/ISBN#ISBN_0198504888
NIF_Subcellular:sao1145756102
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1145756102
NIF_Subcellular:sao1145756102
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1145756102
osmiophilic body
cellular_component
A membrane-bounded vesicle found predominantly in Plasmodium female gametocytes, that becomes progressively more abundant as the gametocyte reaches full maturity. These vesicles lie beneath the subpellicular membrane of the gametocyte, and the release of their contents into the parasitophorous vacuole has been postulated to aid in the escape of gametocytes from the erythrocyte after ingestion by the mosquito.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:18086189
http://purl.org/obo/owl/PMID#PMID_18086189
exoneme
cellular_component
A dense granule-like organelle of the apical complex of merozoites, released into the parasitophorous vacuole, mediating protease-dependent rupture and parasite exit from the infected erythrocyte.
PMID:18083092
http://purl.org/obo/owl/PMID#PMID_18083092
PMID:18083098
http://purl.org/obo/owl/PMID#PMID_18083098
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
crystalloid
cellular_component
A transient, cytoplasmic organelle found in Plasmodium species that resembles a cytoplasmic inclusion body and whose function is poorly understood. Crystalloids form in ookinetes and disappear after ookinete-to-oocyst transformation.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
PMID:19932717
http://purl.org/obo/owl/PMID#PMID_19932717
cone cell pedicle
cellular_component
A specialized axon terminus which is produced by retinal cone cells. Pedicles are large, conical, flat end-feet (8-10 micrometers diameter) of the retinal cone axon that lie more or less side by side on the same plane at the outer edge of the outer plexiform layer (OPL).
URL:http://webvision.med.utah.edu/photo2.html
http://webvision.med.utah.edu/photo2.html
PMID:10939333
http://purl.org/obo/owl/PMID#PMID_10939333
cone pedicle
rod spherule
cellular_component
rod cell spherule
rod photoreceptor spherule
A specialized neuron projection which is the site of synaptic transmission produced by retinal rod cells. Rod spherules are small round enlargements of the axon (3-5 micrometers diameter) or even extensions of the cell body.
URL:http://webvision.med.utah.edu/photo2.html
http://webvision.med.utah.edu/photo2.html
endoplasmic reticulum quality control compartment
cellular_component
ER-derived quality control compartment
ERQC
A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins.
PMID:11408579
http://purl.org/obo/owl/PMID#PMID_11408579
ER quality control compartment
dendritic spine neck
cellular_component
Part of the dendritic spine that connects the dendritic shaft to the head of the dendritic spine.
GOC:nln
http://purl.org/obo/owl/GOC#GOC_nln
dendritic spine head
cellular_component
Distal part of the dendritic spine, that carries the post-synaptic density.
GOC:nln
http://purl.org/obo/owl/GOC#GOC_nln
pinosome
cellular_component
A membrane-bounded, uncoated intracellular vesicle formed by the process of pinocytosis.
PMID:14731589
http://purl.org/obo/owl/PMID#PMID_14731589
PMID:14732047
http://purl.org/obo/owl/PMID#PMID_14732047
micropinosome
cellular_component
A membrane-bounded, uncoated intracellular vesicle formed by the process of micropinocytosis.
PMID:14731589
http://purl.org/obo/owl/PMID#PMID_14731589
PMID:14732047
http://purl.org/obo/owl/PMID#PMID_14732047
macropinosome
cellular_component
A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis.
PMID:14732047
http://purl.org/obo/owl/PMID#PMID_14732047
host chromosome
cellular_component
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information, occurring within a host cell.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell outer membrane
cellular_component
The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites, occurring in a host cell.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
integral to membrane of host cell
cellular_component
Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. Occurring in a host cell.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
integral to host endoplasmic reticulum membrane
cellular_component
Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. Occurring in a host cell.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
ribosomal subunit
cellular_component
Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
microspike
Although in some literature 'microspike' and 'filopodium' are used synonymously, in GO microspike refers to a cell projection that is distinct from a filopodium. See also 'filopodium ; GO:0030175'.
cellular_component
A dynamic, actin-rich projection extending from the surface of a migrating animal cell.
PMID:19095735
http://purl.org/obo/owl/PMID#PMID_19095735
PMID:12153987
http://purl.org/obo/owl/PMID#PMID_12153987
PMID:11429692
http://purl.org/obo/owl/PMID#PMID_11429692
extracellular matrix part
cellular_component
Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
extracellular region part
cellular_component
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
organelle part
cellular_component
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
virion part
cellular_component
Any constituent part of a virion, a complete fully infectious extracellular virus particle.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
intracellular part
cellular_component
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
membrane part
cellular_component
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
cell wall part
cellular_component
Any constituent part of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
chromosomal part
cellular_component
chromosome part
chromosome component
chromosomal component
Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
nuclear part
cellular_component
nucleus component
Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
mitochondrial part
cellular_component
mitochondrion component
Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
cytoskeletal part
cellular_component
Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
cytoskeleton component
Golgi apparatus part
cellular_component
Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
Golgi component
endoplasmic reticulum part
cellular_component
ER component
Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
cytoplasmic vesicle part
cellular_component
Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
chloroplast part
cellular_component
Any constituent part of a chloroplast, a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
plastid part
cellular_component
Any constituent part of a plastid, a member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
thylakoid part
cellular_component
Any constituent part of a thylakoid, a sac-like vesicle that bears the photosynthetic pigments in photosynthetic organisms.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
vacuolar part
cellular_component
vacuole component
Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
microbody part
cellular_component
Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
peroxisomal part
cellular_component
peroxisome component
Any constituent part of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2).
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
endosomal part
cellular_component
endosome component
Any constituent part of an endosome, a membrane-bounded organelle to which materials ingested by endocytosis are delivered.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:19696797
http://purl.org/obo/owl/PMID#PMID_19696797
cilium part
cellular_component
Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
microtubule-based flagellum part
cellular_component
Any constituent part of a microtubule-based flagellum, a long, whiplike protrusion from the surface of a eukaryotic cell, whose undulations drive the cell through a liquid medium; similar in structure to a cilium. The flagellum is based on a 9+2 arrangement of microtubules. Examples of this component are found in Mus musculus.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
flagellar part
pilus part
cellular_component
fimbrium component
Any constituent part of a pilus, a proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
fimbrial part
pilus component
cytoplasmic part
cellular_component
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
cytoplasm component
cytosolic part
cellular_component
cytosol component
Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
intracellular organelle part
cellular_component
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
axoneme part
cellular_component
Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
cell cortex part
cellular_component
Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
contractile fiber part
cellular_component
muscle fibre component
muscle fiber component
contractile fibre component
Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
microtubule organizing center part
cellular_component
microtubule organizing centre component
Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
MTOC component
nucleoplasm part
cellular_component
Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
nucleolar part
cellular_component
nucleolus component
Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
nuclear membrane part
cellular_component
Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
nuclear chromosome part
cellular_component
Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
mitochondrial membrane part
cellular_component
Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
synapse part
cellular_component
Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
cell septum part
cellular_component
Any constituent part of a cell septum, a structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
plasma membrane part
cellular_component
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
flagellum part
cellular_component
Any constituent part of a flagellum, a long whiplike or feathery structure borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
flagellum component
bacterial-type flagellum part
cellular_component
flagellin-based flagellum part
Any constituent part of flagellum, a 20 nm diameter filament composed of subunits of flagellin driven passively at its base by a motor powered by the transmembrane proton potential. Examples of this component are found in bacterial species.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
external encapsulating structure part
cellular_component
Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
cell projection part
cellular_component
Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
cell part
cellular_component
protoplast
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Any constituent part of a cell, the basic structural and functional unit of all organisms.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
supraspliceosomal complex
cellular_component
Multicomponent complex of RNA and proteins that is composed of four active spliceosomes, termed native spliceosomes, connected to each other by the pre-mRNA. The supraspliceosome is the nuclear machine where the pre-mRNA processing takes place, like the 5'-end capping, 3'-end cleavage, splicing and editing.
PMID:19282290
http://purl.org/obo/owl/PMID#PMID_19282290
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
GOC:ans
http://purl.org/obo/owl/GOC#GOC_ans
supraspliceosome complex
host cell periphery
cellular_component
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures of a host cell.
PMID:20463076
http://purl.org/obo/owl/PMID#PMID_20463076
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
NSL complex
cellular_component
non-specific lethal complex
A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1.
GOC:lb
http://purl.org/obo/owl/GOC#GOC_lb
PMID:20018852
http://purl.org/obo/owl/PMID#PMID_20018852
primary cell wall cellulose synthase complex
cellular_component
primary cell wall CESA complex
primary cell-wall cellulose synthase complex
A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant primary cell wall. In Arabidopsis, contains the essential component proteins CESA1 and -3, and a CESA6-related protein.
PMID:21307367
http://purl.org/obo/owl/PMID#PMID_21307367
PMID:17878302
http://purl.org/obo/owl/PMID#PMID_17878302
GOC:tt
http://purl.org/obo/owl/GOC#GOC_tt
GOC:mengo_curators
http://purl.org/obo/owl/GOC#GOC_mengo_curators
secondary cell wall cellulose synthase complex
cellular_component
A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant secondary cell wall. In Arabidopsis, contains the essential component proteins CESA8, CESA7, and CESA4.
GOC:mengo_curators
http://purl.org/obo/owl/GOC#GOC_mengo_curators
GOC:tt
http://purl.org/obo/owl/GOC#GOC_tt
PMID:21307367
http://purl.org/obo/owl/PMID#PMID_21307367
secondary cell wall CesA complex
secondary cell-wall cellulose synthase complex
secondary cell wall CESA complex
[Ni-Fe] hydrogenase complex
cellular_component
A microbial enzyme complex which contains nickel and iron in its active site. In Acetomicrobium flavidum it is an alpha 2 beta 2 tetramer.
PMID:8936309
http://purl.org/obo/owl/PMID#PMID_8936309
GOC:tt
http://purl.org/obo/owl/GOC#GOC_tt
GOC:mengo_curators
http://purl.org/obo/owl/GOC#GOC_mengo_curators
nickel-iron hydrogenase complex
Ni-Fe hydrogenase complex
starch utilization system complex
cellular_component
A bacterial cell envelope-associated multiprotein system, which binds and degrades starch.
GOC:mengo_curators
http://purl.org/obo/owl/GOC#GOC_mengo_curators
GOC:tt
http://purl.org/obo/owl/GOC#GOC_tt
PMID:19553672
http://purl.org/obo/owl/PMID#PMID_19553672
Sus complex
AP-5 adaptor complex
cellular_component
adaptor protein-5 adaptor complex
An AP-type membrane coat adaptor complex that in humans consists of beta5, zeta, mu5 and sigma5 subunits and is found associated with membranes in the endosomes; it is not clear whether AP-5 forms clathrin coats in vivo.
PMID:22022230
http://purl.org/obo/owl/PMID#PMID_22022230
DBIRD complex
cellular_component
A protein complex that associates with mRNP particles and RNA polymerase II and is proposed to integrate transcript elongation with the regulation of alternative splicing. In humans it is composed of the proteins KIAA1967/DBC1 and ZNF326/ZIRD.
GOC:sp
http://purl.org/obo/owl/GOC#GOC_sp
PMID:22446626
http://purl.org/obo/owl/PMID#PMID_22446626
chitosome
cellular_component
An intracellular membrane-bounded particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
PMID:8970154
http://purl.org/obo/owl/PMID#PMID_8970154
mitochondrial degradosome
cellular_component
A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer.
PMID:10397341
http://purl.org/obo/owl/PMID#PMID_10397341
PMID:9829834
http://purl.org/obo/owl/PMID#PMID_9829834
mtEXO
PMID:9829834
http://purl.org/obo/owl/PMID#PMID_9829834
PMID:10397341
http://purl.org/obo/owl/PMID#PMID_10397341
interleukin-18 receptor complex
cellular_component
A protein complex that binds interleukin-18; comprises an alpha and a beta subunit.
PMID:12759435
http://purl.org/obo/owl/PMID#PMID_12759435
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
IL-18 receptor complex
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
keratin filament
cellular_component
A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins.
ISBN:0716731363
http://purl.org/obo/owl/ISBN#ISBN_0716731363
basic/neutral keratin
acidic keratin
acidic keratin
This term was made obsolete because it represents a gene product.
cellular_component
type I intermediate filament
OBSOLETE. A type of intermediate filament.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
ISBN:0716731363
http://purl.org/obo/owl/ISBN#ISBN_0716731363
basic/neutral keratin
This term was made obsolete because it represents a gene product.
cellular_component
type II intermediate filament
OBSOLETE. A type of intermediate filament.
ISBN:0716731363
http://purl.org/obo/owl/ISBN#ISBN_0716731363
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
type III intermediate filament
cellular_component
A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments.
ISBN:0716731363
http://purl.org/obo/owl/ISBN#ISBN_0716731363
vimentin
type III intermediate filament associated protein
peripherin
glial fibrillary acidic protein
desmin
vimentin
This term was made obsolete because it represents a gene product.
cellular_component
OBSOLETE. A type of intermediate filament.
ISBN:0716731363
http://purl.org/obo/owl/ISBN#ISBN_0716731363
desmin
This term was made obsolete because it represents a gene product.
cellular_component
OBSOLETE. A type of intermediate filament.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
glial fibrillary acidic protein
This term was made obsolete because it represents a gene product.
cellular_component
GFAP
OBSOLETE. Glial fibrillary acidic protein forms filaments in the glial cells that surround neurons and in astrocytes.
ISBN:0716731363
http://purl.org/obo/owl/ISBN#ISBN_0716731363
peripherin
This term was made obsolete because it represents a gene product.
cellular_component
OBSOLETE. Peripherin is a type III intermediate filament protein found in neurons of the peripheral nervous system.
ISBN:0716731363
http://purl.org/obo/owl/ISBN#ISBN_0716731363
intermediate filament cytoskeleton
cellular_component
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
ISBN:0716731363
http://purl.org/obo/owl/ISBN#ISBN_0716731363
pronucleus
cellular_component
Wikipedia:Pronucleus
http://purl.org/obo/owl/Wikipedia#Wikipedia_Pronucleus
The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
membrane raft
cellular_component
GEM domain
glycolipid-enriched membrane domain
Wikipedia:Lipid_raft
http://purl.org/obo/owl/Wikipedia#Wikipedia_Lipid_raft
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
PMID:16645198
http://purl.org/obo/owl/PMID#PMID_16645198
lipid raft
myosin I complex
cellular_component
A myosin complex containing a class I myosin heavy chain and associated light chains; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments; myosin I complexes are involved in diverse processes related to membrane traffic and cell movement.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
URL:http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html
PMID:9438839
http://purl.org/obo/owl/PMID#PMID_9438839
fusome
cellular_component
A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
PMID:12655376
http://purl.org/obo/owl/PMID#PMID_12655376
spectrosome
cellular_component
A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
intercellular bridge
cellular_component
A direct link between the cytoplasms of sister cells that allows cells to communicate with one another. Germline intercellular bridges facilitate the passage of cytoplasmic components between cells during development. Intercellular bridges have also been found connecting somatic cells.
PMID:9635420
http://purl.org/obo/owl/PMID#PMID_9635420
germline ring canal
cellular_component
Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:9635420
http://purl.org/obo/owl/PMID#PMID_9635420
PMID:9655801
http://purl.org/obo/owl/PMID#PMID_9655801
apical part of cell
cellular_component
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
ISBN:0815316194
http://purl.org/obo/owl/ISBN#ISBN_0815316194
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
basal part of cell
cellular_component
The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0185316194
http://purl.org/obo/owl/ISBN#ISBN_0185316194
apical cortex
cellular_component
The region that lies just beneath the plasma membrane on the apical edge of a cell.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
basal cortex
cellular_component
The region that lies just beneath the plasma membrane on the basal edge of a cell.
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
synapse
cellular_component
synaptic junction
The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
NIF_Subcellular:sao914572699
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao914572699
Wikipedia:Chemical_synapse
http://purl.org/obo/owl/Wikipedia#Wikipedia_Chemical_synapse
integral to cell outer membrane
cellular_component
Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the external outer membrane of the cell. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
integral to external membrane
integral to outer membrane
postsynaptic membrane
cellular_component
post-synaptic membrane
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
tricarboxylic acid cycle enzyme complex
cellular_component
TCA cycle enzyme complex
Any of the heteromeric enzymes that act in the TCA cycle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
dihydrolipoyl dehydrogenase complex
cellular_component
2-oxoglutarate dehydrogenase complex
A protein complex that possesses alpha-ketoglutarate dehydrogenase activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
alpha-ketoglutarate dehydrogenase complex
cytosolic alpha-ketoglutarate dehydrogenase complex
cellular_component
2-oxoglutarate dehydrogenase complex
Cytosolic complex that possesses alpha-ketoglutarate dehydrogenase activity.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
isocitrate dehydrogenase complex (NAD+)
cellular_component
Complex that possesses isocitrate dehydrogenase (NAD+) activity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cytosolic isocitrate dehydrogenase complex (NAD+)
cellular_component
isocitrate dehydrogenase complex (NAD+)
Cytosolic complex that possesses isocitrate dehydrogenase (NAD+) activity.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
succinate-CoA ligase complex (GDP-forming)
GO:0045245
cellular_component
GO:0008325
A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP.
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
EC:6.2.1.4
http://purl.org/obo/owl/EC#EC_6.2.1.4
succinyl-CoA synthetase, GDP-forming
CORUM:392
http://purl.org/obo/owl/CORUM#CORUM_392
cytosolic tricarboxylic acid cycle enzyme complex
cellular_component
Any of the heteromeric enzymes, located in the cytosol, that act in the tricarboxylic acid (TCA) cycle.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
tricarboxylic acid cycle enzyme complex
TCA cycle enzyme complex
cytosolic electron transfer flavoprotein complex
cellular_component
A protein complex located in the cytosol containing flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
cytosolic oxoglutarate dehydrogenase complex
See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'.
cellular_component
A cytosolic complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:10848975
http://purl.org/obo/owl/PMID#PMID_10848975
cytosol pyruvate dehydrogenase (lipoamide) phosphatase complex
See also the cellular component term 'cytosolic pyruvate dehydrogenase complex ; GO:0045250'.
cellular_component
A cytosolic complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:9395502
http://purl.org/obo/owl/PMID#PMID_9395502
cytosolic pyruvate dehydrogenase complex
Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
cellular_component
Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0471331309
http://purl.org/obo/owl/ISBN#ISBN_0471331309
ISBN:0716720094
http://purl.org/obo/owl/ISBN#ISBN_0716720094
pyruvate dehydrogenase complex (lipoamide)
electron transfer flavoprotein complex
cellular_component
A protein complex containing flavin adenine dinucleotide (FAD) and acyl-CoA dehydrogenase, which form a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
oxoglutarate dehydrogenase complex
See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'.
cellular_component
dihydrolipoamide S-succinyltransferase complex
A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).
MetaCyc:CPLX66-42
http://purl.org/obo/owl/MetaCyc#MetaCyc_CPLX66-42
PMID:10848975
http://purl.org/obo/owl/PMID#PMID_10848975
pyruvate dehydrogenase (lipoamide) phosphatase complex
See also the cellular component term 'cytosolic pyruvate dehydrogenase complex ; GO:0045250'.
cellular_component
A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.
PMID:9395502
http://purl.org/obo/owl/PMID#PMID_9395502
pyruvate dehydrogenase complex
Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
GO:0009364
cellular_component
dihydrolipoyl dehydrogenase complex
pyruvate dehydrogenase complex (lipoamide)
Wikipedia:Pyruvate_dehydrogenase_complex
http://purl.org/obo/owl/Wikipedia#Wikipedia_Pyruvate_dehydrogenase_complex
Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3).
ISBN:0716720094
http://purl.org/obo/owl/ISBN#ISBN_0716720094
succinate dehydrogenase complex (ubiquinone)
cellular_component
The enzyme that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration.
GOC:kd
http://purl.org/obo/owl/GOC#GOC_kd
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
plasma membrane succinate dehydrogenase complex (ubiquinone)
cellular_component
The enzyme, located in the plasma membrane, that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration.
GOC:kd
http://purl.org/obo/owl/GOC#GOC_kd
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
proton-transporting ATP synthase complex
cellular_component
GO:0045255
hydrogen-translocating F-type ATPase complex
hydrogen-transporting ATP synthase complex
A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
EC:3.6.3.14
http://purl.org/obo/owl/EC#EC_3.6.3.14
ISBN:0716743663
http://purl.org/obo/owl/ISBN#ISBN_0716743663
proton-transporting F-type ATPase complex
plasma membrane proton-transporting ATP synthase complex
cellular_component
GO:0045256
hydrogen-transporting ATP synthase
plasma membrane hydrogen-translocating F-type ATPase complex
A proton-transporting ATP synthase complex found in the plasma membrane. Examples of this component are found in Bacterial species.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
proton-transporting ATP synthase complex
hydrogen-translocating F-type ATPase complex
proton-transporting ATP synthase complex, catalytic core F(1)
cellular_component
hydrogen-transporting ATP synthase, F1 sector
The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:10838056
http://purl.org/obo/owl/PMID#PMID_10838056
plasma membrane proton-transporting ATP synthase complex, catalytic core F(1)
See also the cellular component term 'plasma membrane ; GO:0005886'.
cellular_component
proton-transporting ATP synthase complex, catalytic core F(1)
hydrogen-transporting ATP synthase, F1 sector
The catalytic sector of the plasma membrane hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the plasma membrane when the entire ATP synthase is assembled. Examples of this component are found in Bacterial species.
PMID:10838056
http://purl.org/obo/owl/PMID#PMID_10838056
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
proton-transporting ATP synthase complex, coupling factor F(o)
cellular_component
proton-transporting ATP synthase complex, coupling factor F(0)
hydrogen-transporting ATP synthase, F0 sector
hydrogen-transporting ATP synthase, coupling factor CF(0)
hydrogen-transporting ATP synthase complex, coupling factor F(o)
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins.
PMID:10838056
http://purl.org/obo/owl/PMID#PMID_10838056
plasma membrane proton-transporting ATP synthase complex, coupling factor F(o)
cellular_component
proton-transporting ATP synthase complex, coupling factor F(0)
hydrogen-transporting ATP synthase, F0 sector
All non-F1 subunits of the plasma membrane hydrogen-transporting ATP synthase, including integral and peripheral plasma membrane proteins.
PMID:10838056
http://purl.org/obo/owl/PMID#PMID_10838056
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
proton-transporting ATP synthase complex, coupling factor F(o)
proton-transporting ATP synthase, stator stalk
cellular_component
hydrogen-transporting ATP synthase, stator stalk
One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; is thought to prevent futile rotation of the catalytic core.
PMID:10838056
http://purl.org/obo/owl/PMID#PMID_10838056
plasma membrane proton-transporting ATP synthase, stator stalk
cellular_component
hydrogen-transporting ATP synthase, stator stalk
proton-transporting ATP synthase, stator stalk
One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. Examples of this component are found in Bacterial species.
PMID:10838056
http://purl.org/obo/owl/PMID#PMID_10838056
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
proton-transporting ATP synthase, catalytic core
cellular_component
The hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase.
PMID:10838056
http://purl.org/obo/owl/PMID#PMID_10838056
hydrogen-transporting ATP synthase, catalytic core
plasma membrane proton-transporting ATP synthase, catalytic core
cellular_component
proton-transporting ATP synthase, catalytic core
The hexamer that possesses the catalytic activity of the plasma membrane hydrogen-transporting ATP synthase. Examples of this component are found in Bacterial species.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:10838056
http://purl.org/obo/owl/PMID#PMID_10838056
hydrogen-transporting ATP synthase, catalytic core
proton-transporting ATP synthase, central stalk
cellular_component
hydrogen-transporting ATP synthase, central stalk
One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis.
PMID:10838056
http://purl.org/obo/owl/PMID#PMID_10838056
plasma membrane proton-transporting ATP synthase, central stalk
cellular_component
proton-transporting ATP synthase, central stalk
hydrogen-transporting ATP synthase, central stalk
One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated Fo proteins; rotates within the catalytic core during catalysis. Examples of this component are found in Bacterial species.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:10838056
http://purl.org/obo/owl/PMID#PMID_10838056
respiratory chain complex I
Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (ubiquinone) activity ; GO:0008137'.
cellular_component
GO:0045279
electron transport complex I
NADH-Q oxidoreductase complex
NADH dehydrogenase complex (ubiquinone)
Respiratory chain complex I is an enzyme of the respiratory chain. It consists of several polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex.
GOC:imk
http://purl.org/obo/owl/GOC#GOC_imk
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
ISBN:0716749556
http://purl.org/obo/owl/ISBN#ISBN_0716749556
NADH dehydrogenase (ubiquinone) complex
plasma membrane respiratory chain complex I
cellular_component
A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. Examples of this component are found in Bacterial species.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
respiratory chain complex I
NADH dehydrogenase (ubiquinone) complex
respiratory chain complex II
cellular_component
A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
electron transport complex II
plasma membrane respiratory chain complex II
cellular_component
respiratory chain complex II
A part of the respiratory chain located in the plasma membrane, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. Examples of this component are found in Bacterial species.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
respiratory chain complex III
GO:0045285
cellular_component
GO:0032842
A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two protons across a membrane. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome c1, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species.
PMID:17200733
http://purl.org/obo/owl/PMID#PMID_17200733
PMID:16352458
http://purl.org/obo/owl/PMID#PMID_16352458
PMID:16228398
http://purl.org/obo/owl/PMID#PMID_16228398
ubiquinol-cytochrome-c reductase complex
ubiquinol-cytochrome c oxidoreductase complex
Wikipedia:Coenzyme_Q_-_cytochrome_c_reductase
http://purl.org/obo/owl/Wikipedia#Wikipedia_Coenzyme_Q_-_cytochrome_c_reductase
complex III
electron transport complex III
cytochrome bc1 complex
cytochrome bc(1) complex
plasma membrane respiratory chain complex III
GO:0045286
cellular_component
A part of the respiratory chain located in the plasma membrane, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. Examples of this component are found in Bacterial species.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
respiratory chain complex III
ubiquinol-cytochrome c oxidoreductase complex
ubiquinol-cytochrome-c reductase complex
plasma membrane ubiquinol-cytochrome-c reductase complex
respiratory chain complex IV
cellular_component
GO:0045287
electron transport complex IV
A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
cytochrome c oxidase complex
plasma membrane respiratory chain complex IV
GO:0045288
cellular_component
A part of the respiratory chain located in the plasma membrane, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). Examples of this component are found in Bacterial species.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
respiratory chain complex IV
cytochrome c oxidase complex
succinate dehydrogenase complex
cellular_component
A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones.
InterPro:IPR000701
http://purl.org/obo/owl/InterPro#InterPro_IPR000701
GOC:kd
http://purl.org/obo/owl/GOC#GOC_kd
plasma membrane succinate dehydrogenase complex
cellular_component
A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind/react with quinones. Examples of this component are found in Bacterial species.
GOC:kd
http://purl.org/obo/owl/GOC#GOC_kd
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
InterPro:IPR000701
http://purl.org/obo/owl/InterPro#InterPro_IPR000701
succinate dehydrogenase complex
fumarate reductase complex
See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'.
cellular_component
A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR004224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)).
InterPro:IPR003418
http://purl.org/obo/owl/InterPro#InterPro_IPR003418
InterPro:IPR004224
http://purl.org/obo/owl/InterPro#InterPro_IPR004224
plasma membrane fumarate reductase complex
See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'.
cellular_component
A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR00224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. In some species, the complex has only three subunits, and in these cases, there is only one membrane anchor instead of two. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). Examples of this component are found in Bacterial species.
InterPro:IPR003418
http://purl.org/obo/owl/InterPro#InterPro_IPR003418
InterPro:IPR004224
http://purl.org/obo/owl/InterPro#InterPro_IPR004224
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
fumarate reductase complex
mRNA editing complex
cellular_component
A protein complex that posttranscriptionally catalyzes insertion, deletion or substitution of nucleotides at multiple sites within nascent mRNA transcripts to produce mature mRNAs in eukaryotes.
URL:http://www.ejbiotechnology.info/content/vol1/issue1/full/4/
http://www.ejbiotechnology.info/content/vol1/issue1/full/4/
PMID:11564867
http://purl.org/obo/owl/PMID#PMID_11564867
PMID:12139607
http://purl.org/obo/owl/PMID#PMID_12139607
editosome
tubulin complex
cellular_component
A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly.
ISBN:0716731363
http://purl.org/obo/owl/ISBN#ISBN_0716731363
chloroplast proton-transporting ATP synthase complex
cellular_component
A proton-transporting ATP synthase complex found in the chloroplast thylakoid membrane; it catalyzes the phosphorylation of ADP to ATP during photo-phosphorylation.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ISBN:0716743663
http://purl.org/obo/owl/ISBN#ISBN_0716743663
GOC:pj
http://purl.org/obo/owl/GOC#GOC_pj
chloroplast proton-transporting F-type ATPase complex
chloroplast hydrogen-translocating F-type ATPase complex
hydrogen-translocating F-type ATPase complex
interleukin-1 receptor complex
cellular_component
IL-1 receptor complex
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A protein complex that binds interleukin-1; comprises an alpha and a beta subunit.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
InterPro:IPR004075
http://purl.org/obo/owl/InterPro#InterPro_IPR004075
clathrin-coated endocytic vesicle
cellular_component
A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
NIF_Subcellular:sao1243595998
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1243595998
phagocytic vesicle
cellular_component
Wikipedia:Phagosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Phagosome
phagosome
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
clathrin-coated phagocytic vesicle
cellular_component
clathrin-coated phagosome
A clathrin-coated, membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
pole plasm
cellular_component
polar plasm
Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo.
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
PMID:17113380
http://purl.org/obo/owl/PMID#PMID_17113380
germ plasm
dosage compensation complex
cellular_component
A protein or protein-RNA complex that localizes to one or more of the sex chromosome(s), where it acts to normalize transcription between different sexes.
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
U4/U6 x U5 tri-snRNP complex
cellular_component
A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins.
PMID:11867543
http://purl.org/obo/owl/PMID#PMID_11867543
U4/U6.U5 snRNP complex
intercellular canaliculus
cellular_component
An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates.
ISBN:0721662544
http://purl.org/obo/owl/ISBN#ISBN_0721662544
lysosomal proton-transporting V-type ATPase, V0 domain
cellular_component
lysosomal hydrogen ion-transporting ATPase V0 domain
The V0 domain of a proton-transporting V-type ATPase found in the lysosomal membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
lysosomal proton-transporting V-type ATPase complex
cellular_component
lysosomal membrane hydrogen-transporting ATPase
lysosomal hydrogen-translocating V-type ATPase complex
A proton-transporting two-sector ATPase complex found in the lysosomal membrane, where it acts as a proton pump to mediate acidification of the lysosomal lumen.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0716743663
http://purl.org/obo/owl/ISBN#ISBN_0716743663
PMID:16449553
http://purl.org/obo/owl/PMID#PMID_16449553
lysosomal proton-transporting V-type ATPase, V1 domain
cellular_component
lysosomal hydrogen ion-transporting ATPase V1 domain
The V1 domain of a proton-transporting V-type ATPase found in the lysosomal membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
anchored to plasma membrane
cellular_component
Tethered to the plasma membrane by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. When used to describe a protein, indicates that the peptide sequence does not span the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
plasma membrane, GPI-anchored
intracellular canaliculus
cellular_component
An apical plasma membrane part that forms a narrow enfolded luminal membrane channel, lined with numerous microvilli, that appears to extend into the cytoplasm of the cell. A specialized network of intracellular canaliculi is a characteristic feature of parietal cells of the gastric mucosa in vertebrates.
PMID:10700045
http://purl.org/obo/owl/PMID#PMID_10700045
ISBN:0721662544
http://purl.org/obo/owl/ISBN#ISBN_0721662544
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
SLIK (SAGA-like) complex
See also the cellular component term 'SAGA complex ; GO:0000124'.
cellular_component
SALSA complex
SAGA (alt) complex
A SAGA-type histone acetyltransferase complex that contains Rtg2 and a smaller form of Spt7 than the fungal SAGA complex, and lacks Spt8. The complex is involved in the yeast retrograde response pathway, which is important for gene expression changes during mitochondrial dysfunction.
PMID:17337012
http://purl.org/obo/owl/PMID#PMID_17337012
PMID:12186975
http://purl.org/obo/owl/PMID#PMID_12186975
PMID:12101232
http://purl.org/obo/owl/PMID#PMID_12101232
SLIK/SALSA complex
lipopolysaccharide receptor complex
Note that this term should not be used to refer to CD14 alone, but the multiprotein receptor complex that it is part of.
cellular_component
A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated.
PMID:11706042
http://purl.org/obo/owl/PMID#PMID_11706042
LPS receptor complex
capsomere
cellular_component
capsomer
Wikipedia:Capsomere
http://purl.org/obo/owl/Wikipedia#Wikipedia_Capsomere
Any of the protein subunits that comprise the closed shell or coat (capsid) of certain viruses.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
viral procapsid
cellular_component
A stable empty viral capsid produced during the assembly of viruses.
ISBN:0072370319
http://purl.org/obo/owl/ISBN#ISBN_0072370319
ISBN:1555811272
http://purl.org/obo/owl/ISBN#ISBN_1555811272
viral portal complex
cellular_component
A multimeric ring of proteins through which the DNA enters and exits the viral capsid.
PMID:11602732
http://purl.org/obo/owl/PMID#PMID_11602732
viral scaffold
cellular_component
A complex of proteins that form a scaffold around which the viral capsid is constructed.
ISBN:0072370319
http://purl.org/obo/owl/ISBN#ISBN_0072370319
assemblon
cellular_component
Antigenically dense structures located at the periphery of nuclei, close to but not abutting nuclear membranes. Assemblons contain the proteins for immature-capsid assembly; they are located at the periphery of a diffuse structure composed of proteins involved in DNA synthesis, which overlaps only minimally with the assemblons. More than one site can be present simultaneously.
PMID:8676489
http://purl.org/obo/owl/PMID#PMID_8676489
replication compartment
cellular_component
Globular nuclear domains where the transcription and replication of the viral genome occurs. More than one site can be present simultaneously.
PMID:9499108
http://purl.org/obo/owl/PMID#PMID_9499108
virion transport vesicle
cellular_component
A vesicle used to transport the partial or complete virion between cellular compartments.
PMID:7933124
http://purl.org/obo/owl/PMID#PMID_7933124
dense nuclear body
cellular_component
A location in the host cell nucleus where viral proteins colocalize late in infection prior to the onset of viral DNA synthesis. More than one site can be present simultaneously.
PMID:10233976
http://purl.org/obo/owl/PMID#PMID_10233976
extrachromosomal DNA
cellular_component
DNA structures that are not part of a chromosome.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
Wikipedia:Extrachromosomal_DNA
http://purl.org/obo/owl/Wikipedia#Wikipedia_Extrachromosomal_DNA
chlorosome
cellular_component
Wikipedia:Chlorosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Chlorosome
A large enclosure of aggregated pigment, typically bacteriochlorophyll c (BChl c), that acts as a light-harvesting antenna structure and is characteristic of green photosynthetic bacteria (e.g. Chlorobiaceae). The BChl aggregates are organized into lamellar elements by pigment-pigment rather than pigment-protein interactions. Chlorosomes also contain BChl a, carotenoids, quinones, lipids, and proteins, and are attached to the cytoplasmic membrane via a BChl a-containing protein baseplate.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
PMID:14729689
http://purl.org/obo/owl/PMID#PMID_14729689
PMID:15298919
http://purl.org/obo/owl/PMID#PMID_15298919
hydrogenosomal membrane
cellular_component
hydrogenosome membrane
The lipid bilayer surrounding a hydrogenosome.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
glycosome membrane
cellular_component
The lipid bilayer surrounding a glycosome.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
glyoxysomal membrane
cellular_component
glyoxysome membrane
The lipid bilayer surrounding a glyoxysome.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
chromoplast membrane
cellular_component
Either of the lipid bilayers that surround a chromoplast and form the chromoplast envelope.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mesosome
cellular_component
Wikipedia:Mesosome
http://purl.org/obo/owl/Wikipedia#Wikipedia_Mesosome
An intracellular, often complex, membranous structure, sometimes with additional membranous lamellae inside, found in bacteria. They are associated with synthesis of DNA and secretion of proteins.
ISBN:0716731363
http://purl.org/obo/owl/ISBN#ISBN_0716731363
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
pore complex
cellular_component
pore-forming toxin activity
pore
channel-forming toxin activity
Any small opening in a membrane that allows the passage of gases and/or liquids.
ISBN:0198506732
http://purl.org/obo/owl/ISBN#ISBN_0198506732
apoplast
cellular_component
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
Wikipedia:Apoplast
http://purl.org/obo/owl/Wikipedia#Wikipedia_Apoplast
activin receptor complex
cellular_component
A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed.
PMID:8622651
http://purl.org/obo/owl/PMID#PMID_8622651
PMID:8307945
http://purl.org/obo/owl/PMID#PMID_8307945
activin complex
Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'.
cellular_component
A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits, inhibin beta-A and inhibin beta-B (sometimes known as activin beta or activin/inhibin beta). There are three forms of activin complex, activin A, which is composed of 2 inhibin beta-A subunits, activin B, which is composed of 2 inhibin beta-B subunits, and activin AB, which is composed of an inhibin beta-A and an inhibin beta-B subunit.
URL:http://www.mercksource.com
http://www.mercksource.com
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
URL:http://www.stedmans.com/
http://www.stedmans.com/
activin AB complex
Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'.
cellular_component
A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits (sometimes known as activin beta or activin/inhibin beta), inhibin beta-A and inhibin beta-B.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
URL:http://www.stedmans.com/
http://www.stedmans.com/
URL:http://www.mercksource.com
http://www.mercksource.com
inhibin beta-A
inhibin beta-B
Set1C/COMPASS complex
cellular_component
A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.
PMID:11687631
http://purl.org/obo/owl/PMID#PMID_11687631
PMID:11742990
http://purl.org/obo/owl/PMID#PMID_11742990
PMID:11805083
http://purl.org/obo/owl/PMID#PMID_11805083
PMID:12488447
http://purl.org/obo/owl/PMID#PMID_12488447
PMID:18508253
http://purl.org/obo/owl/PMID#PMID_18508253
PMID:18838538
http://purl.org/obo/owl/PMID#PMID_18838538
Set1C
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
Set1/COMPASS complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
COMPASS complex
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
Lid2 complex
cellular_component
A protein complex that is thought to be involved in regulation of chromatin remodeling. In Schizosaccharomyces the complex contains Lid1p, Ash2p, Ecm5p, Snt2p, and Sdc1p.
PMID:12488447
http://purl.org/obo/owl/PMID#PMID_12488447
plant extracellular matrix
Note that this term does not have 'extracellular region ; GO:0005576' as a parent because in plants the extracellular matrix is considered part of the cell.
cellular_component
middle lamella-containing extracellular matrix
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
The matrix external to the plant plasma membrane, composed of the cell wall and middle lamella.
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:11351084
http://purl.org/obo/owl/PMID#PMID_11351084
PMID:4327466
http://purl.org/obo/owl/PMID#PMID_4327466
pectic matrix
cellular_component
The gel-like pectin matrix consists of the interlinked acidic and neutral pectin networks that are further cross-linked by calcium bridges. Pectins consist largely of long chains of mostly galacturonic acid units (typically 1,4 linkages and sometimes methyl esters). Three major pectic polysaccharides (homogalacturonan, rhamnogalacturonan I and rhamnogalacturonan II) are thought to occur in all primary cell walls.
PMID:11554482
http://purl.org/obo/owl/PMID#PMID_11554482
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
glycoprotein network
cellular_component
An extracellular matrix part that consists of cross-linked glycoproteins.
PMID:7048321
http://purl.org/obo/owl/PMID#PMID_7048321
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:18508691
http://purl.org/obo/owl/PMID#PMID_18508691
extensin
Wikipedia:Extensin
http://purl.org/obo/owl/Wikipedia#Wikipedia_Extensin
hemicellulose network
cellular_component
Network composed of hemicelluloses; members of a class of plant cell wall polysaccharide that cannot be extracted from the wall by hot water or chelating agents, but can be extracted by aqueous alkali. Includes xylan, glucuronoxylan, arabinoxylan, arabinogalactan II, glucomannan, xyloglucan and galactomannan.
DOI:10.1016/j.foodchem.2008.11.065
http://purl.org/obo/owl/DOI#DOI_10.1016/j.foodchem.2008.11.065
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
lignin network
cellular_component
An extracellular matrix part that consists of lignin in the form of a three-dimensional polymeric network. Lignins are complex racemic aromatic heteropolymers derived from a variety of phenylpropane monomers coupled together by an assortment of carbon-carbon and ether linkages. Lignin is crucial for structural integrity of the cell wall and stiffness and strength of the stem. In addition, lignin waterproofs the cell wall, enabling transport of water and solutes through the vascular system, and plays a role in protecting plants against pathogens.
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
PMID:16662709
http://purl.org/obo/owl/PMID#PMID_16662709
PMID:14503002
http://purl.org/obo/owl/PMID#PMID_14503002
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
suberin network
cellular_component
An extracellular matrix part that consists of fatty acid-derived polymers, including both aromatic and aliphatic components. The suberin network is found in specialized plant cell walls, where it is laid down between the primary wall and plasma membrane, forms protective and wound-healing layers, and provides a water-impermeable diffusion barrier.
PMID:18440267
http://purl.org/obo/owl/PMID#PMID_18440267
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:7706282
http://purl.org/obo/owl/PMID#PMID_7706282
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
Casparian strip
cellular_component
Region of plant cell wall specialised to act as a seal to prevent back leakage of secreted material (analogous to tight junction between epithelial cells). Found particularly where root parenchymal cells secrete solutes into xylem vessels. The barrier is composed of suberin; a fatty substance, containing long chain fatty acids and fatty esters, also found in the cell walls of cork cells (phellem) in higher plants.
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
Wikipedia:Casparian_strip
http://purl.org/obo/owl/Wikipedia#Wikipedia_Casparian_strip
rough endoplasmic reticulum lumen
cellular_component
RER lumen
NIF_Subcellular:sao1819509473
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao1819509473
The volume enclosed by the membranes of the rough endoplasmic reticulum.
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
rough ER lumen
smooth endoplasmic reticulum lumen
cellular_component
SER lumen
NIF_Subcellular:sao927884761
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao927884761
The volume enclosed by the membranes of the smooth endoplasmic reticulum.
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
smooth ER lumen
methionine adenosyltransferase complex
cellular_component
A multimeric enzyme complex composed of variable numbers of catalytic alpha subunits, and noncatalytic beta subunits. The beta subunits are believed to have a regulatory function. The enzyme complex catalyzes the synthesis of S-adenosylmethionine (AdoMet), which is the major methyl group donor, participating in the methylation of proteins, DNA, RNA, phospholipids, and other small molecules.
PMID:10644686
http://purl.org/obo/owl/PMID#PMID_10644686
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
EC:2.5.1.6
http://purl.org/obo/owl/EC#EC_2.5.1.6
MAT complex
primary endosperm nucleus
cellular_component
Nucleus resulting from the fusion of the male gamete and two polar nuclei in the central cell of the embryo sac.
ISBN:0471245208
http://purl.org/obo/owl/ISBN#ISBN_0471245208
perinuclear region of cytoplasm
Note that this term should not be confused with the cellular component term 'nuclear membrane lumen ; GO:0005641', which has the synonym 'perinuclear space'.
cellular_component
Cytoplasm situated near, or occurring around, the nucleus.
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
coated membrane
cellular_component
A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes.
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
Holliday junction resolvase complex
cellular_component
Mus81-Eme1 complex
A protein complex that mediates the conversion of a Holliday junction into two separate duplex DNA molecules; the complex includes a single- or multisubunit helicase that catalyzes the extension of heteroduplex DNA by branch migration and a nuclease that resolves the junction by nucleolytic cleavage.
PMID:11207366
http://purl.org/obo/owl/PMID#PMID_11207366
PMID:12374758
http://purl.org/obo/owl/PMID#PMID_12374758
resolvasome
PMID:11207366
http://purl.org/obo/owl/PMID#PMID_11207366
ribulose bisphosphate carboxylase complex
cellular_component
RubisCO complex
A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
plasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex
cellular_component
A complex, located in the plasma membrane-derived thylakoid, containing either both large and small subunits or just small subunits. It carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
ribulose bisphosphate carboxylase complex
RubisCO complex
plasma membrane ribulose bisphosphate carboxylase complex
chromatophore ribulose bisphosphate carboxylase complex
cellular_component
RubisCO complex
A complex, located in the chromatophore, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
signal recognition particle
cellular_component
Wikipedia:Signal_recognition_particle
http://purl.org/obo/owl/Wikipedia#Wikipedia_Signal_recognition_particle
A complex of protein and RNA which facilitates translocation of proteins across membranes.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
signal recognition particle, plasma membrane targeting
cellular_component
A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to or across the plasma membrane.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
generative cell nucleus
cellular_component
male germ cell nucleus
sperm cell nucleus
The nucleus of the generative cell, a cell contained within the pollen grain that will divide to produce two haploid sperm cells.
GOC:tair_curators
http://purl.org/obo/owl/GOC#GOC_tair_curators
microsporocyte nucleus
cellular_component
GO:0043074
pollen mother cell nucleus
The nucleus of the microsporocyte. The microsporocyte is a diploid cell in which meiosis will occur, resulting in four microspores. A microspore is a spore that, in vascular plants, gives rise to a male gametophyte.
ISBN:047186840X
http://purl.org/obo/owl/ISBN#ISBN_047186840X
GOC:tair_curators
http://purl.org/obo/owl/GOC#GOC_tair_curators
microspore mother cell nucleus
pigment granule
cellular_component
A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes.
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
GOC:mh
http://purl.org/obo/owl/GOC#GOC_mh
presynaptic active zone
cellular_component
pre-synaptic active zone
A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, synaptic vesicles, and a specialized cortical cytoskeletal matrix.
GOC:dl
http://purl.org/obo/owl/GOC#GOC_dl
GOC:dh
http://purl.org/obo/owl/GOC#GOC_dh
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
GOC:ef
http://purl.org/obo/owl/GOC#GOC_ef
PMID:3152289
http://purl.org/obo/owl/PMID#PMID_3152289
NIF_Subcellular:sao792027222
http://purl.org/obo/owl/NIF_Subcellular#NIF_Subcellular_sao792027222
presynaptic active zone membrane
cellular_component
active zone plasma membrane
active zone presynaptic plasma membrane
The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters.
PMID:12812759
http://purl.org/obo/owl/PMID#PMID_12812759
PMID:3152289
http://purl.org/obo/owl/PMID#PMID_3152289
PMID:12923177
http://purl.org/obo/owl/PMID#PMID_12923177
active zone pre-synaptic plasma membrane
pre-synaptic active zone membrane
presynaptic cytoskeletal matrix assembled at active zones
cellular_component
pre-synaptic cytoskeletal matrix assembled at active zones
T-bar ribbon
PMID:16384719
http://purl.org/obo/owl/PMID#PMID_16384719
T-bar
PMID:20127822
http://purl.org/obo/owl/PMID#PMID_20127822
The specialized cytoskeletal matrix assembled at the active zones of the presynaptic nerve terminal. The cytoskeletal matrix is a proteinaceous structure involved in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. The cytomatrix protein exclusively assembled at active zones, is thought to form a molecular scaffold that organizes neurotransmitter release sites.
GOC:dh
http://purl.org/obo/owl/GOC#GOC_dh
GOC:ef
http://purl.org/obo/owl/GOC#GOC_ef
GOC:dl
http://purl.org/obo/owl/GOC#GOC_dl
PMID:10944438
http://purl.org/obo/owl/PMID#PMID_10944438
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
synaptic ribbon
PMID:19264728
http://purl.org/obo/owl/PMID#PMID_19264728
presynaptic cytomatrix assembled at active zones
presynaptic dense body
PMID:16709774
http://purl.org/obo/owl/PMID#PMID_16709774
CAZ
secondary cell septum
cellular_component
Cell wall structures composed of linear polysaccharides which are deposited at both sides of the primary septum at 90 degrees to the primary septum.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
PMID:15194814
http://purl.org/obo/owl/PMID#PMID_15194814
secondary septum
spindle midzone
cellular_component
spindle equator
central spindle
PMID:14528012
http://purl.org/obo/owl/PMID#PMID_14528012
The area in the center of the spindle where the spindle microtubules from opposite poles overlap.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
PMID:15296749
http://purl.org/obo/owl/PMID#PMID_15296749
cell cortex of cell tip
cellular_component
cell cortex of cell end
The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell.
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
cell tip
Note that this term differs from 'cell pole ; GO:0060187' in that it is applicable to a narrower range of cell shapes.
cellular_component
The region at either end of the longest axis of a cylindrical or elongated cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:ai
http://purl.org/obo/owl/GOC#GOC_ai
cell end
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
tRNA-specific adenosine-34 deaminase complex
cellular_component
A protein complex that possesses tRNA-specific adenosine-34 deaminase activity. In eukaryotes the complex is a heterodimer; the subunits are known as Tad2p and Tad3p in yeasts and Adat2 and Adat3 in human.
PMID:17875641
http://purl.org/obo/owl/PMID#PMID_17875641
tRNA-A34 deaminase complex
cortical microtubule
cellular_component
Arrays of microtubules underlying and connected to the plasma membrane in the cortical cytosol.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
nuclear DNA-directed RNA polymerase complex
cellular_component
A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
gamma-tubulin large complex, equatorial microtubule organizing center
cellular_component
A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located at equatorial microtubule organizing centers.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
gamma-tubulin large complex, equatorial microtubule organizing centre
gamma-tubulin large complex, eMTOC
gamma-tubulin large complex, spindle pole body
cellular_component
A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located in the spindle pole body.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
gamma-tubulin large complex, interphase microtubule organizing center
cellular_component
gamma-tubulin large complex, iMTOC
A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located at interphase microtubule organizing centers.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
gamma-tubulin large complex, interphase microtubule organizing centre
plastid thylakoid membrane
cellular_component
The lipid bilayer membrane of any thylakoid within a plastid.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
virion membrane
cellular_component
The lipid bilayer surrounding a virion.
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
PMID:213106
http://purl.org/obo/owl/PMID#PMID_213106
recycling endosome
cellular_component
endosome recycling compartment
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
PMID:12370264
http://purl.org/obo/owl/PMID#PMID_12370264
Organelle consisting of networks of 60nm tubules organized around the microtubule organizing centre in some cell types. They transport receptors from late endosomes back to the plasma membrane for recycling and are also involved in membrane trafficking.
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
PMID:10930469
http://purl.org/obo/owl/PMID#PMID_10930469
PMID:15601896
http://purl.org/obo/owl/PMID#PMID_15601896
PMID:16246101
http://purl.org/obo/owl/PMID#PMID_16246101
ERC
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
PMID:1237064
http://purl.org/obo/owl/PMID#PMID_1237064
recycling endosome membrane
cellular_component
The lipid bilayer surrounding a recycling endosome.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
PMID:10930469
http://purl.org/obo/owl/PMID#PMID_10930469
PMID:15601896
http://purl.org/obo/owl/PMID#PMID_15601896
PMID:16246101
http://purl.org/obo/owl/PMID#PMID_16246101
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
trichocyst
cellular_component
A crystalline exocytotic organelle composed of small, acidic proteins existing primarily as disulphide-linked dimers. The trichocyst is an organelle that releases long filamentous proteins that capture predators in "nets" to slow them down when the cell is disturbed. The protein is nontoxic and shaped like a long, striated, fibrous shaft.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
URL:http://www.iscid.org/encyclopedia/
http://www.iscid.org/encyclopedia/
PMID:3667715
http://purl.org/obo/owl/PMID#PMID_3667715
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
Wikipedia:Trichocyst
http://purl.org/obo/owl/Wikipedia#Wikipedia_Trichocyst
periplasmic flagellum
cellular_component
Flagellar filaments located in the periplasmic space; characterized in spirochetes, in which they are essential for shape and motility. Composed of a core surrounded by two sheath layers, the flagella rotate to allow migration of the cell through viscous media, which would not be possible using external flagella.
GOC:jid
http://purl.org/obo/owl/GOC#GOC_jid
PMID:15175283
http://purl.org/obo/owl/PMID#PMID_15175283
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
PMID:1624463
http://purl.org/obo/owl/PMID#PMID_1624463
symplast
cellular_component
The interconnected cell membranes and intracellular regions of a plant. The interconnections occur via the plasmodesmata.
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
Wikipedia:Symplast
http://purl.org/obo/owl/Wikipedia#Wikipedia_Symplast
ATP-binding cassette (ABC) transporter complex, integrated substrate binding
cellular_component
A complex for the transport of metabolites out of the cell, consisting of 4 domains: two ATP-binding domains and two membrane spanning domains. In some cases, all 4 domains are contained on 1 polypeptide, while in others one ATP-binding domain and one membrane spanning domain are together on one polypeptide in what is called a "half transporter". Two "half-transporters" come together to form a functional transporter. Transport of the substrate across the membrane is driven by the hydrolysis of ATP.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
cellular_component
A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP.
GOC:mlg
http://purl.org/obo/owl/GOC#GOC_mlg
GOC:mtg_sensu
http://purl.org/obo/owl/GOC#GOC_mtg_sensu
Ski complex
cellular_component
Wikipedia:Ski_complex
http://purl.org/obo/owl/Wikipedia#Wikipedia_Ski_complex
A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p.
PMID:18042677
http://purl.org/obo/owl/PMID#PMID_18042677
PMID:16043509
http://purl.org/obo/owl/PMID#PMID_16043509
PMID:15703439
http://purl.org/obo/owl/PMID#PMID_15703439
PMID:10744028
http://purl.org/obo/owl/PMID#PMID_10744028
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
striated muscle dense body
cellular_component
A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere.
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
PMID:17492481
http://purl.org/obo/owl/PMID#PMID_17492481
Nic96 complex
cellular_component
A protein complex that forms part of the nuclear pore complex, and is required for its correct assembly. In Saccharomyces cerevisiae Nic96 contains Nsp1p, Nup57p, Nup49p, and Nic96p.
PMID:12791264
http://purl.org/obo/owl/PMID#PMID_12791264
PMID:15741174
http://purl.org/obo/owl/PMID#PMID_15741174
GOC:jh
http://purl.org/obo/owl/GOC#GOC_jh
Nup82 complex
cellular_component
A protein complex that forms part of the nuclear pore complex. It forms a subcomplex with Nup159p and Nsp1p, interacts with Nup116p, and is required for proper localization of Nup116p. In Saccharomyces cerevisiae this complex contains Nup82p, Nsp1p, Nup159p, Nup116p, and Gle2p.
PMID:12791264
http://purl.org/obo/owl/PMID#PMID_12791264
PMID:15741174
http://purl.org/obo/owl/PMID#PMID_15741174
GOC:jh
http://purl.org/obo/owl/GOC#GOC_jh
neurofilament cytoskeleton
cellular_component
Intermediate filament cytoskeletal structure that is made up of neurofilaments. Neurofilaments are specialized intermediate filaments found in neurons.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
excitatory synapse
cellular_component
Wikipedia:Excitatory_synapse
http://purl.org/obo/owl/Wikipedia#Wikipedia_Excitatory_synapse
A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
GOC:ef
http://purl.org/obo/owl/GOC#GOC_ef
inhibitory synapse
cellular_component
A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
GOC:ef
http://purl.org/obo/owl/GOC#GOC_ef
Wikipedia:Inhibitory_postsynaptic_potential
http://purl.org/obo/owl/Wikipedia#Wikipedia_Inhibitory_postsynaptic_potential
kinocilium
cellular_component
A nonmotile primary cilium that is found at the apical surface of auditory receptor cells. The kinocilium is surrounded by actin-based stereocilia.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
PMID:15882574
http://purl.org/obo/owl/PMID#PMID_15882574
Wikipedia:Kinocilium
http://purl.org/obo/owl/Wikipedia#Wikipedia_Kinocilium
collagen and cuticulin-based cuticle extracellular matrix
cellular_component
collagen and cuticulin-based exoskeleton extracellular matrix
A collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer. The cuticle serves essential functions in body morphology, locomotion, and environmental protection. An example of this component is found in Caenorhabditis elegans.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
ISSN:15518507
http://purl.org/obo/owl/ISSN#ISSN_15518507
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
collagen and cuticulin-based cuticle extracellular matrix part
cellular_component
Any constituent part of the collagen and cuticulin-based cuticle extracellular matrix, a collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
surface coat of collagen and cuticulin-based cuticle extracellular matrix
cellular_component
surface coat of collagen and cuticulin-based exoskeleton extracellular matrix
An electron dense, amorphous envelope that comprises the outermost layer of the cuticle. The surface coat is loosely apposed to the epicuticle, has distinct biochemical properties, is synthesized by cells other than the underlying hypodermis, and is labile. In addition to serving as a lubricant to protect against abrasion and dehydration, the surface coat may also play important roles in infection and immune evasion. An example of this component is found in Caenorhabditis elegans.
ISSN:15518507
http://purl.org/obo/owl/ISSN#ISSN_15518507
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
epicuticle of collagen and cuticulin-based cuticle extracellular matrix
cellular_component
epicuticle of collagen and cuticulin-based exoskeleton extracellular matrix
A lipid-containing layer of cuticle that lies between the cortical layer and the surface coat. An example of this component is found in Caenorhabditis elegans.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
ISSN:15518507
http://purl.org/obo/owl/ISSN#ISSN_15518507
cortical layer of collagen and cuticulin-based cuticle extracellular matrix
cellular_component
The cuticle layer that lies directly beneath the lipid-containing epicuticle. The cortical layer contains collagens and insoluble, non-collagenous cuticulins and is characterized by a distinct annular pattern consisting of regularly spaced annular ridges delineated by annular furrows. An example of this component is found in Caenorhabditis elegans.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
ISSN:15518507
http://purl.org/obo/owl/ISSN#ISSN_15518507
annuli extracellular matrix
cellular_component
The extracellular matrix that is a regularly spaced circumferential ridge present in the cortical region of the cuticle. Annuli are delineated by annular furrows and are present throughout the cuticle with the exception of lateral regions where longitudinal alae are present.
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
ISSN:15518507
http://purl.org/obo/owl/ISSN#ISSN_15518507
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
annule(s)
annulus
annulae
annular rings
annular furrow extracellular matrix
cellular_component
The extracellular matrix part that is a regularly spaced indentation in the outer cortical layer of the cuticle. The pattern of annular furrows corresponds to sites of invaginations in hypodermal cell membranes that, in turn, correspond to submembranous regions where actin microfilament bundles assemble early in lethargus, the first phase of the molting cycle in which activity and feeding decline.
ISSN:15518507
http://purl.org/obo/owl/ISSN#ISSN_15518507
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
medial layer of collagen and cuticulin-based cuticle extracellular matrix
cellular_component
The fluid-filled cuticle layer that lies between the cortical and basal layers and is characterized by the presence of regularly spaced columnar struts that lie on either side of the annular furrows and link the two surrounding layers. In C. elegans, a defined medial layer is found only in adult animals.
ISSN:15518507
http://purl.org/obo/owl/ISSN#ISSN_15518507
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
medial layer struts
basal layer of collagen and cuticulin-based cuticle extracellular matrix
cellular_component
basal layer of collagen and cuticulin-based exoskeleton extracellular matrix
The layer of cuticle most closely apposed to the hypodermal cells. The morphology of the basal layer varies with life stage. In adult C. elegans animals, the basal layers is comprised of three sublayers: two fibrous layers whose fibers run in clockwise and counter-clockwise directions meeting one another at a 60 degree angle, and an amorphous basal layer that lies underneath the fibrous layers and directly contacts the hypodermis. In C. elegans dauer and L1 larval stage animals, the basal layer is characterized by a striated pattern that appears to derive from interwoven laminae. An example of this component is found in Caenorhabditis elegans.
ISSN:15518507
http://purl.org/obo/owl/ISSN#ISSN_15518507
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
alae of collagen and cuticulin-based cuticle extracellular matrix
cellular_component
alae of collagen and cuticulin-based exoskeleton extracellular matrix
Raised, thickened cuticular ridges that run longitudinally, and in parallel, along the left and right sides of the animal. The alae lie above the hypodermal cells known as the lateral seam cells. In C. elegans, alae are produced in L1 larvae, dauer larvae and adult stage animals, where they consist of three, five, and three ridges of distinct morphology, respectively.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
ISSN:15518507
http://purl.org/obo/owl/ISSN#ISSN_15518507
cilium membrane
cellular_component
The portion of the plasma membrane surrounding a cilium.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
stereocilium membrane
cellular_component
The portion of the plasma membrane surrounding a stereocilium.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
cell pole
Note that this term differs from 'cell tip ; GO:0051286' in that it is applicable to a broader range of cell shapes.
cellular_component
Either of two different areas at opposite ends of an axis of a cell.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
clathrin sculpted vesicle
cellular_component
A clathrin sculpted lipid bilayer membrane-enclosed vesicle after clathrin release.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
clathrin sculpted glutamate transport vesicle
cellular_component
clathrin sculpted glutamate constitutive secretory pathway transport vesicle
A clathrin sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing glutamate.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
clathrin sculpted acetylcholine transport vesicle
cellular_component
A clathrin sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing acetylcholine.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle
clathrin sculpted acetylcholine transport vesicle membrane
cellular_component
The lipid bilayer surrounding a clathrin sculpted acetylcholine transport vesicle.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle membrane
clathrin sculpted acetylcholine transport vesicle lumen
cellular_component
clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle lumen
The volume enclosed by the membrane of the clathrin sculpted acetylcholine transport vesicle.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
clathrin sculpted glutamate transport vesicle membrane
cellular_component
clathrin sculpted glutamate constitutive secretory pathway transport vesicle membrane
The lipid bilayer surrounding a clathrin sculpted glutamate transport vesicle.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
clathrin sculpted glutamate transport vesicle lumen
cellular_component
The volume enclosed by the membrane of the clathrin sculpted glutamate transport vesicle.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
clathrin sculpted glutamate constitutive secretory pathway transport vesicle lumen
cytoplasmic membrane-bounded vesicle lumen
cellular_component
The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
cytoplasmic membrane-enclosed vesicle lumen
germ plasm
cellular_component
Differentiated cytoplasm associated with a pole of an oocyte, egg or early embryo that will be inherited by the cells that will give rise to the germ line.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
Wikipedia:Germ_plasm
http://purl.org/obo/owl/Wikipedia#Wikipedia_Germ_plasm
photoreceptor inner segment membrane
cellular_component
The membrane surrounding the outer segment of a vertebrate photoreceptor. The photoreceptor inner segment contains mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
fertilization envelope
cellular_component
fertilization membrane
A structure that lies outside the plasma membrane and surrounds the egg. The fertilization envelope forms from the vitelline membrane after fertilization as a result of cortical granule release.
ISBN:0878932437
http://purl.org/obo/owl/ISBN#ISBN_0878932437
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
vitelline envelope
cellular_component
fertilization membrane
A glycoprotein-based structure that lies outside the plasma membrane and surrounds the egg before fertilization.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
ISBN:0878932437
http://purl.org/obo/owl/ISBN#ISBN_0878932437
yolk
cellular_component
The cytoplasmic part that serves as a nutrient reserve or energy source for the developing embryo.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
PMID:18046696
http://purl.org/obo/owl/PMID#PMID_18046696
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
yolk plasma
cellular_component
Discrete structures that partition the water-soluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
PMID:18046696
http://purl.org/obo/owl/PMID#PMID_18046696
cortical granule
cellular_component
A secretory vesicle that is stored under the cell membrane of an egg. These vesicles fuse with the egg plasma membrane as part of egg activation and are part of the block to polyspermy.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
cortical vesicle
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
lipid tube
cellular_component
A macromolecular complex that contains a tube of lipid surrounded by a protein coat.
GOC:ascb_2009
http://purl.org/obo/owl/GOC#GOC_ascb_2009
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
type I terminal button
cellular_component
Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters that will induce the contraction of muscle. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
type I terminal bouton
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
type II terminal button
cellular_component
Terminal inflated portion of the axon of a non-glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters at a regulatory synapse. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
type II terminal bouton
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
type Ib terminal button
cellular_component
Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the tonic release neurotransmitters that will induce the contraction of muscle. Type Ib terminal buttons are larger than type Is terminal buttons.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
type Ib terminal bouton
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
type Is terminal button
cellular_component
Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the phasic release neurotransmitters that will induce the contraction of muscle. Type Is terminal buttons are smaller than type Ib terminal buttons.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
type Is terminal bouton
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
clathrin sculpted gamma-aminobutyric acid transport vesicle
cellular_component
A clathrin sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing gamma-aminobutyric acid transport vesicle.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
clathrin sculpted GABA transport vesicle
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
clathrin sculpted gamma-aminobutyric acid transport vesicle lumen
cellular_component
clathrin sculpted GABA transport vesicle lumen
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
The volume enclosed by the membrane of the clathrin sculpted gamma-aminobutyric acid transport vesicle.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
clathrin sculpted gamma-aminobutyric acid transport vesicle membrane
cellular_component
clathrin sculpted GABA transport vesicle membrane
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
The lipid bilayer surrounding a clathrin sculpted gamma-aminobutyric acid transport vesicle.
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
extracellular membrane-bounded organelle
cellular_component
Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell.
GOC:isa_complete
http://purl.org/obo/owl/GOC#GOC_isa_complete
extracellular membrane-enclosed organelle
intracellular organelle lumen
cellular_component
An organelle lumen that is part of an intracellular organelle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
sucrase-isomaltase complex
cellular_component
Wikipedia:Sucrase-isomaltase
http://purl.org/obo/owl/Wikipedia#Wikipedia_Sucrase-isomaltase
A protein complex that possesses oligo-1,6-glucosidase activity; the complex is a heterodimer located in the cell membrane, and is formed by proteolytic cleavage of a single precursor polypeptide. The two subunits have different substrate specificities.
PMID:3366777
http://purl.org/obo/owl/PMID#PMID_3366777
oligo-1,6-glucosidase complex
alphav-beta3 integrin-thrombospondin complex
cellular_component
A protein complex that consists of an alphav-beta3 integrin complex bound to thrombospondin.
PMID:2478219
http://purl.org/obo/owl/PMID#PMID_2478219
ITGAV-ITGB3-THBS1 complex
CORUM:2846
http://purl.org/obo/owl/CORUM#CORUM_2846
transforming growth factor beta type I receptor homodimeric complex
cellular_component
A receptor complex that consists of two transforming growth factor beta (TGF-beta) type I receptor monomers. TGF-beta type I receptor dimers form in the presence or absence of ligand, and can associate with ligand-bound TGF-beta type II receptor dimers.
Reactome:REACT_7737
http://purl.org/obo/owl/Reactome#Reactome_REACT_7737
TGF-beta type I receptor complex
TGF-beta type I receptor dimer
Reactome:REACT_7737
http://purl.org/obo/owl/Reactome#Reactome_REACT_7737
transforming growth factor beta type I receptor complex
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
TGFBR1 homodimer
Reactome:REACT_7737
http://purl.org/obo/owl/Reactome#Reactome_REACT_7737
transforming growth factor beta type II receptor homodimeric complex
cellular_component
TGF-beta type II receptor complex
transforming growth factor beta type II receptor complex
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
TGFBR2 homodimer
Reactome:REACT_7415
http://purl.org/obo/owl/Reactome#Reactome_REACT_7415
TGF-beta type II receptor dimer
Reactome:REACT_7415
http://purl.org/obo/owl/Reactome#Reactome_REACT_7415
A receptor complex that consists of two transforming growth factor beta (TGF-beta) type II receptor monomers. TGF-beta type II receptor dimers form in the presence or absence of ligand, and upon ligand binding can associate with TGF-beta type I receptor dimers.
Reactome:REACT_7415
http://purl.org/obo/owl/Reactome#Reactome_REACT_7415
transforming growth factor beta1-type II receptor complex
cellular_component
A protein complex that consists of a dimeric transforming growth factor beta (TGF-beta) type II receptor bound to a TGF-beta1 dimer.
Reactome:REACT_7218
http://purl.org/obo/owl/Reactome#Reactome_REACT_7218
TGF-beta1-type II receptor complex
Reactome:REACT_7218
http://purl.org/obo/owl/Reactome#Reactome_REACT_7218
TGF-beta receptor II-TGF-beta1 complex
transforming growth factor beta1-type II receptor-type I receptor complex
cellular_component
A protein complex that is formed by the association of a ligand-bound TGF-beta type II receptor dimer with a TGF-beta type I receptor dimer.
Reactome:REACT_7425
http://purl.org/obo/owl/Reactome#Reactome_REACT_7425
TGF-beta 1:type II receptor:type I receptor complex
Reactome:REACT_7425
http://purl.org/obo/owl/Reactome#Reactome_REACT_7425
TGF-beta1-type II receptor-type I receptor complex
TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex
transforming growth factor beta receptor homodimeric complex
cellular_component
A homodimeric receptor complex that consists of two TGF-beta receptor monomers.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Reactome:REACT_7737
http://purl.org/obo/owl/Reactome#Reactome_REACT_7737
Reactome:REACT_7415
http://purl.org/obo/owl/Reactome#Reactome_REACT_7415
transforming growth factor beta receptor complex
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
TGF-beta receptor complex
interleukin-12-interleukin-12 receptor complex
cellular_component
IL12-IL12 receptor complex
IL12B-IL12RB1-IL12RB2 complex
CORUM:2020
http://purl.org/obo/owl/CORUM#CORUM_2020
A protein complex that is formed by the association of a heterodimeric interleukin-12 receptor complex with an interleukin-12 heterodimer.
PMID:11900991
http://purl.org/obo/owl/PMID#PMID_11900991
CD19-Vav-PIK3R1 complex
cellular_component
A protein complex that contains the cell surface signaling molecule CD19, the Ras guanine nucleotide exchange factor Vav, and the regulatory subunit alpha of phosphatidylinositol 3-kinase (PI3K).
PMID:7528218
http://purl.org/obo/owl/PMID#PMID_7528218
CD19-Vav-PI 3-kinase (p85 subunit) complex
CORUM:2574
http://purl.org/obo/owl/CORUM#CORUM_2574
alphav-beta3 integrin-osteopontin complex
cellular_component
ITGAV-ITGB3-SPP1 complex
CORUM:2358
http://purl.org/obo/owl/CORUM#CORUM_2358
A protein complex that consists of an alphav-beta3 integrin complex bound to osteopontin.
PMID:7532190
http://purl.org/obo/owl/PMID#PMID_7532190
alphav-beta1 integrin-osteopontin complex
cellular_component
ITGAV-ITGB1-SPP1 complex
CORUM:2885
http://purl.org/obo/owl/CORUM#CORUM_2885
A protein complex that consists of an alphav-beta1 integrin complex bound to osteopontin.
PMID:7592829
http://purl.org/obo/owl/PMID#PMID_7592829
alphav-beta5 integrin-osteopontin complex
cellular_component
ITGAV-ITGB5-SPP1 complex
CORUM:2347
http://purl.org/obo/owl/CORUM#CORUM_2347
A protein complex that consists of an alphav-beta5 integrin complex bound to osteopontin.
PMID:7592829
http://purl.org/obo/owl/PMID#PMID_7592829
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
cellular_component
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof).
PMID:7553862
http://purl.org/obo/owl/PMID#PMID_7553862
SNARE complex (Vamp2, Snap25, Stx1a, Cplx1)
CORUM:795
http://purl.org/obo/owl/CORUM#CORUM_795
Vamp2-Snap25-Stx1a-Cplx1 complex
CORUM:795
http://purl.org/obo/owl/CORUM#CORUM_795
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
cellular_component
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof).
PMID:7553862
http://purl.org/obo/owl/PMID#PMID_7553862
SNARE complex (Vamp2, Snap25, Stx1a, Cplx2)
CORUM:796
http://purl.org/obo/owl/CORUM#CORUM_796
Vamp2-Snap25-Stx1a-Cplx2 complex
CORUM:796
http://purl.org/obo/owl/CORUM#CORUM_796
synaptobrevin 2-SNAP-25-syntaxin-1a complex
cellular_component
Stx1a-SNAP25-VAMP complex
CORUM:841
http://purl.org/obo/owl/CORUM#CORUM_841
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof).
PMID:10336434
http://purl.org/obo/owl/PMID#PMID_10336434
SNARE complex (Stx1a, SNAP25, VAMP)
CORUM:841
http://purl.org/obo/owl/CORUM#CORUM_841
Snap25-Stx1a-Vamp2 complex
SNARE complex (Snap25, Stx1a, Vamp2)
CORUM:998
http://purl.org/obo/owl/CORUM#CORUM_998
synaptobrevin 2-SNAP-25-syntaxin-2 complex
cellular_component
Stx2-Snap25-Vamp2 complex
CORUM:851
http://purl.org/obo/owl/CORUM#CORUM_851
SNARE complex (Stx2, Snap25, Vamp2)
CORUM:851
http://purl.org/obo/owl/CORUM#CORUM_851
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 2 (or orthologs thereof).
PMID:10336434
http://purl.org/obo/owl/PMID#PMID_10336434
synaptobrevin 2-SNAP-25-syntaxin-3 complex
cellular_component
Stx3-Snap25-Vamp2 complex
CORUM:852
http://purl.org/obo/owl/CORUM#CORUM_852
SNARE complex (Stx3, Snap25, Vamp2)
CORUM:852
http://purl.org/obo/owl/CORUM#CORUM_852
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 3 (or orthologs thereof).
PMID:10336434
http://purl.org/obo/owl/PMID#PMID_10336434
synaptobrevin 2-SNAP-25-syntaxin-4 complex
cellular_component
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 4 (or orthologs thereof).
PMID:10336434
http://purl.org/obo/owl/PMID#PMID_10336434
Stx4-Snap25-Vamp2 complex
CORUM:853
http://purl.org/obo/owl/CORUM#CORUM_853
SNARE complex (Stx4, Snap25, Vamp2)
CORUM:853
http://purl.org/obo/owl/CORUM#CORUM_853
endobrevin-SNAP-25-syntaxin-1a complex
cellular_component
A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 1a (or orthologs thereof).
PMID:10336434
http://purl.org/obo/owl/PMID#PMID_10336434
SNARE complex (Stx1a, Snap25, Vamp8)
CORUM:854
http://purl.org/obo/owl/CORUM#CORUM_854
Stx1a-Snap25-Vamp8 complex
CORUM:854
http://purl.org/obo/owl/CORUM#CORUM_854
endobrevin-SNAP-25-syntaxin-2 complex
cellular_component
SNARE complex (Stx2, Snap25, Vamp8)
CORUM:855
http://purl.org/obo/owl/CORUM#CORUM_855
Stx2-Snap25-Vamp8 complex
CORUM:855
http://purl.org/obo/owl/CORUM#CORUM_855
A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 2 (or orthologs thereof).
PMID:10336434
http://purl.org/obo/owl/PMID#PMID_10336434
prospore membrane leading edge
cellular_component
The region of the prospore membrane that extends to surround the spore nucleus; coated with specific proteins that are thought to play a role in prospore membrane organization.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:14702385
http://purl.org/obo/owl/PMID#PMID_14702385
forespore membrane leading edge
prospore membrane spindle pole body attachment site
cellular_component
prospore membrane SPB attachment site
The region of the prospore membrane to which the spindle pole body (SPB) is anchored; the prospore membrane extends from the SPB attachment site to surround the spore nucleus.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:14702385
http://purl.org/obo/owl/PMID#PMID_14702385
forespore membrane spindle pole body attachment site
forespore membrane SPB attachment site
extracellular vesicular exosome
cellular_component
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.
PMID:17641064
http://purl.org/obo/owl/PMID#PMID_17641064
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:15908444
http://purl.org/obo/owl/PMID#PMID_15908444
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
cellubrevin-VAMP4-syntaxin-16 complex
cellular_component
Vamp3-Vamp4-Stx16 complex
CORUM:875
http://purl.org/obo/owl/CORUM#CORUM_875
A SNARE complex that contains cellubrevin (VAMP3), VAMP4, and syntaxin 16 (or orthologs thereof).
PMID:11839770
http://purl.org/obo/owl/PMID#PMID_11839770
SNARE complex (Vamp3, Vamp4, Stx16)
CORUM:875
http://purl.org/obo/owl/CORUM#CORUM_875
cellubrevin-VAMP4-endobrevin-syntaxin-6 complex
cellular_component
SNARE complex (Vamp3, Vamp4, Vam8, Stx6)
CORUM:874
http://purl.org/obo/owl/CORUM#CORUM_874
A SNARE complex that contains cellubrevin (VAMP3), VAMP4, endobrevin (VAMP8), and syntaxin 6 (or orthologs thereof).
PMID:11839770
http://purl.org/obo/owl/PMID#PMID_11839770
Vamp3-Vamp4-Vam8-Stx6 complex
CORUM:874
http://purl.org/obo/owl/CORUM#CORUM_874
syntaxin-6-syntaxin-16-Vti1a complex
cellular_component
A SNARE complex that contains syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof).
PMID:11839770
http://purl.org/obo/owl/PMID#PMID_11839770
VAMP4-syntaxin-6-syntaxin-16-Vti1a complex
cellular_component
SNARE complex (Vamp4, Stx6, Stx16, Vti1a)
CORUM:877
http://purl.org/obo/owl/CORUM#CORUM_877
Vamp4-Stx6-Stx16-Vti1a complex
CORUM:877
http://purl.org/obo/owl/CORUM#CORUM_877
A SNARE complex that contains VAMP4, syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof).
PMID:11839770
http://purl.org/obo/owl/PMID#PMID_11839770
cytochrome complex
cellular_component
A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mononeme
cellular_component
A secretory organelle that forms part of the apical complex; a small, threadlike structure located is close proximity to the subpellicular microtubules. Its contents include a rhomboid protease (PfROM1 in Plasmodium falciparum) that moves from the lateral asymmetric localization to the merozoite apical pole and the posterior pole upon release of merozoites from schizonts.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
PMID:18048320
http://purl.org/obo/owl/PMID#PMID_18048320
clathrin sculpted monoamine transport vesicle
cellular_component
clathrin sculpted monoamine constitutive secretory pathway transport vesicle
A clathrin sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing monoamines.
GOC:mg2
http://purl.org/obo/owl/GOC#GOC_mg2
clathrin sculpted monoamine transport vesicle lumen
cellular_component
The volume enclosed by the membrane of the clathrin sculpted monoamine transport vesicle.
GOC:mg2
http://purl.org/obo/owl/GOC#GOC_mg2
clathrin sculpted monoamine constitutive secretory pathway transport vesicle lumen
clathrin sculpted monoamine transport vesicle membrane
cellular_component
The lipid bilayer surrounding a clathrin sculpted monoamine transport vesicle.
GOC:mg2
http://purl.org/obo/owl/GOC#GOC_mg2
clathrin sculpted monoamine constitutive secretory pathway transport vesicle membrane
PHA granule
cellular_component
polyhydroxyalkanoate granule
PHB granule
An inclusion body located in the cytoplasm that consists of polyhydroxyalkanoate (PHA) molecules and associated proteins, surrounded by a phospholipid monolayer; the proteins include PHA synthase, PHA depolymerase and 3HB-oligomer hydroxylase, phasins (PhaPs), which are thought to be the major structural proteins of the membrane surrounding the inclusion, and the regulator of phasin expression PhaR.
PMID:15762612
http://purl.org/obo/owl/PMID#PMID_15762612
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
metaphase plate
cellular_component
The intracellular plane, located halfway between the poles of the spindle, where chromosomes align during metaphase of mitotic or meiotic nuclear division.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ciliary neurotrophic factor receptor complex
cellular_component
A protein complex that acts as a receptor for the cytokine ciliary neurotrophic factor (CNTF). In humans the receptor complex is a hexamer composed of two molecules each of CNTF and CNTFR and one molecule each of gp130 and LIFR.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
PMID:12707266
http://purl.org/obo/owl/PMID#PMID_12707266
organellar chromatophore
cellular_component
Paulinella-type chromatophore
A bacteroid-containing symbiosome in which the bacterial component is a genetically highly reduced cyanobacterium that is photosynthetically active and incapable of an independent existence outside its host. The chromatophore functions as a photosynthetic organelle, and has been found and characterized in the amoeba Paulinella chromatophora.
PMID:18356055
http://purl.org/obo/owl/PMID#PMID_18356055
GOC:expert_mm
http://purl.org/obo/owl/GOC#GOC_expert_mm
organellar chromatophore membrane
cellular_component
Paulinella-type chromatophore membrane
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Either of the lipid bilayers that surround an organellar chromatophore.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
organellar chromatophore inner membrane
cellular_component
Paulinella-type chromatophore inner membrane
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
The inner, i.e. lumen-facing, of the two lipid bilayers surrounding an organellar chromatophore.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
organellar chromatophore outer membrane
cellular_component
The outer, i.e. cytoplasm-facing, of the two lipid bilayers surrounding an organellar chromatophore.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Paulinella-type chromatophore outer membrane
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
organellar chromatophore intermembrane space
cellular_component
Paulinella-type chromatophore intermembrane space
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
The region between the inner and outer lipid bilayers that surround an organellar chromatophore.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
organellar chromatophore thylakoid
cellular_component
A thylakoid located in an organellar chromatophore.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Paulinella-type chromatophore thylakoid
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
organellar chromatophore thylakoid lumen
cellular_component
The volume enclosed by an organellar chromatophore thylakoid membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Paulinella-type chromatophore thylakoid lumen
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
organellar chromatophore thylakoid membrane
cellular_component
Paulinella-type chromatophore thylakoid membrane
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
The lipid bilayer membrane of any thylakoid within an organellar chromatophore.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
occluding junction
cellular_component
A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other.
ISBN:0815332181
http://purl.org/obo/owl/ISBN#ISBN_0815332181
occluding cell junction
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
anchoring junction
cellular_component
anchoring cell junction
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
ISBN:0815332181
http://purl.org/obo/owl/ISBN#ISBN_0815332181
DRM complex
cellular_component
A transcriptional repressor complex that contains the lin-9, lin-35, lin-37, lin-52, lin-53, lin-5is involved in 4-, dpl-1 and efl-1 proteins, and is involved in cell fate specification.
PMID:17075059
http://purl.org/obo/owl/PMID#PMID_17075059
DP/Rb/MuvB
PMID:17075059
http://purl.org/obo/owl/PMID#PMID_17075059
telosome
cellular_component
Pot1 complex
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
shelterin complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
Pot1-Tpz1 complex
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex contains TRF1, TRF2, POT1, RAP1, TIN2 and TPP1 in mammalian cells, and Pot1, Tpz1, Ccq1, Poz1, and Rap1 in Schizosaccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1.
PMID:18828880
http://purl.org/obo/owl/PMID#PMID_18828880
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:expert_mf
http://purl.org/obo/owl/GOC#GOC_expert_mf
Stn1-Ten1 complex
cellular_component
A nuclear telomere cap complex that is formed by the association of the Stn1 and Ten1 proteins with telomeric DNA; in some species a third protein is present.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:19064932
http://purl.org/obo/owl/PMID#PMID_19064932
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:17715303
http://purl.org/obo/owl/PMID#PMID_17715303
growth hormone receptor complex
cellular_component
A receptor complex that consists of two identical subunits and binds growth hormone.
PMID:11445442
http://purl.org/obo/owl/PMID#PMID_11445442
GOC:vk
http://purl.org/obo/owl/GOC#GOC_vk
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
ASTRA complex
cellular_component
A protein complex that is part of the chromatin remodeling machinery; the acronym stands for ASsembly of Tel, Rvb and Atm-like kinase. In Saccharomyces cerevisiae this complex includes Rvb1p, Rvb2p, Tra1p, Tel2p, Asa1p, Ttilp and Tti2p.
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
PMID:19040720
http://purl.org/obo/owl/PMID#PMID_19040720
Rpd3L-Expanded complex
cellular_component
Clr6-LE complex
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins.
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
PMID:19040720
http://purl.org/obo/owl/PMID#PMID_19040720
Snt2C complex
cellular_component
A histone deacetylase complex that is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains Snt2p, Ecm5p and Rpd3p.
PMID:19040720
http://purl.org/obo/owl/PMID#PMID_19040720
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
CSK-GAP-A.p62 complex
Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
cellular_component
A protein complex that contains the protein-tyrosine kinase CSK and the GTPase-activating protein (GAP)-associated p62 (GAP-A.p62); may mediate translocation of proteins, including GAP and CSK, to membrane or cytoskeletal regions upon c-Src activation.
PMID:7544435
http://purl.org/obo/owl/PMID#PMID_7544435
mating projection membrane
cellular_component
The portion of the plasma membrane surrounding a mating projection, the projection formed by unicellular fungi in response to mating pheromone.
GOC:jp
http://purl.org/obo/owl/GOC#GOC_jp
shmoo membrane
GOC:jp
http://purl.org/obo/owl/GOC#GOC_jp
inner membrane complex
cellular_component
A membrane structure formed of two closely aligned lipid bilayers that lie beneath the plasma membrane and form part of the pellicle surrounding an apicomplexan parasite cell.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:12456714
http://purl.org/obo/owl/PMID#PMID_12456714
external side of fungal-type cell wall
cellular_component
The side of the fungal-type cell wall that is opposite to the side that faces the cell and its contents.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
transcription factor TFIIIE complex
cellular_component
A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIE contains a specific subset of ribosomal proteins.
PMID:19116144
http://purl.org/obo/owl/PMID#PMID_19116144
GOC:jp
http://purl.org/obo/owl/GOC#GOC_jp
RES complex
cellular_component
pre-mRNA retention and splicing complex
GOC:sre
http://purl.org/obo/owl/GOC#GOC_sre
A protein complex that is required for efficient splicing, and prevents leakage of unspliced pre-mRNAs from the nucleus (named for pre-mRNA REtention and Splicing). In Saccharomyces, the complex consists of Ist3p, Bud13p, and Pml1p.
PMID:15565172
http://purl.org/obo/owl/PMID#PMID_15565172
PMID:18809678
http://purl.org/obo/owl/PMID#PMID_18809678
PMID:19010333
http://purl.org/obo/owl/PMID#PMID_19010333
PMID:19033360
http://purl.org/obo/owl/PMID#PMID_19033360
ferritin complex
cellular_component
A protein complex that binds iron and acts as a major iron storage system. Intracellular and extracellular ferritin complexes have different ratios of two types of ferritin monomer, the L (light) chain and H (heavy) chain.
PMID:19154717
http://purl.org/obo/owl/PMID#PMID_19154717
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
extracellular ferritin complex
cellular_component
A ferritin complex located in the extracellular region. Extracellular ferritin complexes contain L (light) chains but few or no H (heavy) chains.
PMID:19154717
http://purl.org/obo/owl/PMID#PMID_19154717
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
serum ferritin complex
PMID:19154717
http://purl.org/obo/owl/PMID#PMID_19154717
ATR-ATRIP complex
cellular_component
Rad3-Rad26 complex
PMID:17339343
http://purl.org/obo/owl/PMID#PMID_17339343
Mec1-Lcd1 complex
PMID:17339343
http://purl.org/obo/owl/PMID#PMID_17339343
A protein complex that contains the protein kinase ATR and ATR-interacting protein (ATRIP) and binds single-stranded DNA; ssDNA binding affinity is increased in the presence of replication protein A.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:14724280
http://purl.org/obo/owl/PMID#PMID_14724280
nucleosomal methylation activator complex
cellular_component
A protein complex that contains eight subunits in common with the SWI/SNF complex, plus the ATPase BRG1 (SMARCA4) and the histone methyltransferase CARM1; the complex is involved in regulating nuclear receptor-dependent transcription.
PMID:14729568
http://purl.org/obo/owl/PMID#PMID_14729568
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
NUMAC
PMID:14729568
http://purl.org/obo/owl/PMID#PMID_14729568
RAD52-ERCC4-ERCC1 complex
Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
cellular_component
A nucleotide-excision repair complex formed by the association of the heterodimeric endonuclease XPF/ERCC4-ERCC1 (Rad1p and Rad10p in S. cerevisiae) with the RAD52 protein.
PMID:14734547
http://purl.org/obo/owl/PMID#PMID_14734547
RGS6-DNMT1-DMAP1 complex
cellular_component
A protein complex formed by the association of RGS6, a negative regulator of heterotrimeric G protein signaling, with the DMAP1-Dnmt1 transcriptional repressor complex; in the complex, RGS6 inhibits the transcriptional repressor activity of DMAP1.
PMID:14734556
http://purl.org/obo/owl/PMID#PMID_14734556
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Golgi to plasma membrane transport vesicle
cellular_component
Golgi to plasma membrane constitutive secretory pathway transport vesicle
Golgi-plasma membrane transport vesicle
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A transport vesicle that mediates transport from the Golgi to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:kad
http://purl.org/obo/owl/GOC#GOC_kad
CD20-Lck-Fyn complex
cellular_component
A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck and Fyn.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:7545683
http://purl.org/obo/owl/PMID#PMID_7545683
CD20-Lck-Lyn-Fyn complex
cellular_component
A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck, Lyn and Fyn.
PMID:7545683
http://purl.org/obo/owl/PMID#PMID_7545683
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
alpha6-beta4 integrin-Shc-Grb2 complex
cellular_component
ITGA6-ITGB4-SHC-GRB2 complex
CORUM:3096
http://purl.org/obo/owl/CORUM#CORUM_3096
A protein complex that consists of an alpha6-beta4 integrin complex bound to the adaptor proteins Shc and Grb2.
PMID:7556090
http://purl.org/obo/owl/PMID#PMID_7556090
alpha6-beta4 integrin-laminin 5 complex
cellular_component
ITGA6-ITGB4-LAMA5 complex
CORUM:2322
http://purl.org/obo/owl/CORUM#CORUM_2322
A protein complex that consists of an alpha6-beta4 integrin complex bound to laminin 5.
PMID:7556090
http://purl.org/obo/owl/PMID#PMID_7556090
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GATA1-TAL1-TCF3-Lmo2 complex
cellular_component
A protein complex that contains the zinc finger transcription factor GATA1, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis.
PMID:7568177
http://purl.org/obo/owl/PMID#PMID_7568177
GATA2-TAL1-TCF3-Lmo2 complex
cellular_component
A protein complex that contains the zinc finger transcription factor GATA2, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis.
PMID:7568177
http://purl.org/obo/owl/PMID#PMID_7568177
synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a-complexin II complex
cellular_component
A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, Rab3a, and complexin II (or orthologs thereof).
PMID:7654227
http://purl.org/obo/owl/PMID#PMID_7654227
SNARE complex (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2, CPLX2)
CORUM:1247
http://purl.org/obo/owl/CORUM#CORUM_1247
STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2-CPLX2 complex
CORUM:1247
http://purl.org/obo/owl/CORUM#CORUM_1247
synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a complex
cellular_component
A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Rab3a (or orthologs thereof).
PMID:7654227
http://purl.org/obo/owl/PMID#PMID_7654227
STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2 complex
CORUM:1244
http://purl.org/obo/owl/CORUM#CORUM_1244
SNARE complex (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2)
CORUM:1244
http://purl.org/obo/owl/CORUM#CORUM_1244
alphav-beta3 integrin-CD47 complex
cellular_component
A protein complex that consists of an alphav-beta3 integrin complex bound to CD47 (also known as IAP).
PMID:2277087
http://purl.org/obo/owl/PMID#PMID_2277087
PMID:7691831
http://purl.org/obo/owl/PMID#PMID_7691831
ITGB3-ITGAV-CD47 complex
CORUM:2356
http://purl.org/obo/owl/CORUM#CORUM_2356
beta-catenin-TCF7L2 complex
cellular_component
A protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
PMID:9065402
http://purl.org/obo/owl/PMID#PMID_9065402
PMID:9065401
http://purl.org/obo/owl/PMID#PMID_9065401
beta-catenin-TCF4 complex
PMID:9065402
http://purl.org/obo/owl/PMID#PMID_9065402
PMID:9065401
http://purl.org/obo/owl/PMID#PMID_9065401
endosome to plasma membrane transport vesicle
cellular_component
endosome-plasma membrane transport vesicle
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A transport vesicle that mediates transport from the endosome to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.
PMID:12110576
http://purl.org/obo/owl/PMID#PMID_12110576
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:10679016
http://purl.org/obo/owl/PMID#PMID_10679016
GOC:kad
http://purl.org/obo/owl/GOC#GOC_kad
endosome to plasma membrane constitutive secretory pathway transport vesicle
exocytic vesicle
cellular_component
exocytotic vesicle
GOC:kad
http://purl.org/obo/owl/GOC#GOC_kad
exocytic constitutive secretory pathway transport vesicle
A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:kad
http://purl.org/obo/owl/GOC#GOC_kad
egasyn-beta-glucuronidase complex
cellular_component
A protein complex that contains beta-glucuronidase and the carboxyl esterase egasyn; formation of the complex causes beta-glucuronidase to be retained in the endoplasmic reticulum.
PMID:7744842
http://purl.org/obo/owl/PMID#PMID_7744842
procollagen-proline 4-dioxygenase complex, alpha(I) type
cellular_component
prolyl 4-hydroxylase complex (alpha(I)-type)
CORUM:472
http://purl.org/obo/owl/CORUM#CORUM_472
procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(I) type
PMID:7753822
http://purl.org/obo/owl/PMID#PMID_7753822
A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type I isoform; its activity is readily inhibited by poly(L-proline).
PMID:7753822
http://purl.org/obo/owl/PMID#PMID_7753822
PMID:14500733
http://purl.org/obo/owl/PMID#PMID_14500733
procollagen-proline 4-dioxygenase complex, alpha(II) type
cellular_component
procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(II) type
PMID:7753822
http://purl.org/obo/owl/PMID#PMID_7753822
prolyl 4-hydroxylase complex (alpha(II)-type)
CORUM:473
http://purl.org/obo/owl/CORUM#CORUM_473
A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type II isoform; its activity is inhibited by poly(L-proline) only at high concentrations.
PMID:7753822
http://purl.org/obo/owl/PMID#PMID_7753822
PMID:14500733
http://purl.org/obo/owl/PMID#PMID_14500733
procollagen-proline 4-dioxygenase complex, alpha(III) type
cellular_component
A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type III isoform.
PMID:14500733
http://purl.org/obo/owl/PMID#PMID_14500733
prolyl 4-hydroxylase complex (alpha(III)-type)
CORUM:474
http://purl.org/obo/owl/CORUM#CORUM_474
procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(III) type
PMID:14500733
http://purl.org/obo/owl/PMID#PMID_14500733
transcription export complex 2
cellular_component
A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sus1p and Cdc31p.
GOC:dgf
http://purl.org/obo/owl/GOC#GOC_dgf
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:17786152
http://purl.org/obo/owl/PMID#PMID_17786152
Sac3-Thp1-Sus1-Cdc31 complex
PMID:17786152
http://purl.org/obo/owl/PMID#PMID_17786152
TREX-2 complex
GOC:dgf
http://purl.org/obo/owl/GOC#GOC_dgf
DNA-dependent protein kinase complex
cellular_component
DNA-dependent protein kinase, DNA-end-binding complex
A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku.
PMID:12235392
http://purl.org/obo/owl/PMID#PMID_12235392
PMID:10854421
http://purl.org/obo/owl/PMID#PMID_10854421
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
DNA-PK complex
DNA-PK-Ku antigen complex
CORUM:355
http://purl.org/obo/owl/CORUM#CORUM_355
nonhomologous end joining complex
cellular_component
non-homologous end joining complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
NHEJ complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:17072889
http://purl.org/obo/owl/PMID#PMID_17072889
PMID:17938628
http://purl.org/obo/owl/PMID#PMID_17938628
Ku-DNA ligase complex
cellular_component
A nonhomologous end joining complex that contains one or more Ku monomers and one or more DNA ligase molecules from the LigC or LigD family, and mediates nonhomologous end joining in bacteria.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:17938628
http://purl.org/obo/owl/PMID#PMID_17938628
DNA ligase III-XRCC1 complex
cellular_component
A protein complex that contains DNA ligase III and XRCC1, and is involved in base excision repair.
PMID:7760816
http://purl.org/obo/owl/PMID#PMID_7760816
PMID:15141024
http://purl.org/obo/owl/PMID#PMID_15141024
G-protein beta/gamma-Raf-1 complex
See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'.
cellular_component
G protein complex (GNG2, GNB2L1, RAF1)
CORUM:1539
http://purl.org/obo/owl/CORUM#CORUM_1539
A protein complex formed by the association of the serine-threonine protein kinase Raf-1 with the beta and gamma subunits of a heterotrimeric G protein.
PMID:7782277
http://purl.org/obo/owl/PMID#PMID_7782277
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Shc-EGFR complex
cellular_component
A protein complex that contains the epidermal growth factor receptor (EGFR) and the adaptor protein Shc, and is involved in linking EGFR activation to the p21-Ras pathway.
PMID:7798267
http://purl.org/obo/owl/PMID#PMID_7798267
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Shc-Egfr complex, EGF stimulated
CORUM:2887
http://purl.org/obo/owl/CORUM#CORUM_2887
Grb2-EGFR complex
cellular_component
A protein complex that contains the epidermal growth factor receptor (EGFR) and Grb2, and is involved in linking EGFR activation to the p21-Ras pathway.
PMID:7798267
http://purl.org/obo/owl/PMID#PMID_7798267
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Grb2-Egfr complex, EGF stimulated
CORUM:2889
http://purl.org/obo/owl/CORUM#CORUM_2889
Grb2-Shc complex
cellular_component
Grb2-Shc complex, EGF stimulated
CORUM:2888
http://purl.org/obo/owl/CORUM#CORUM_2888
A protein complex that contains Grb2 and the adaptor protein Shc, and is involved in linking epidermal growth factor receptor (EGFR) activation to the p21-Ras pathway.
PMID:7798267
http://purl.org/obo/owl/PMID#PMID_7798267
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mTOR-FKBP12-rapamycin complex
cellular_component
Fkbp1a-Frap1 complex
CORUM:2987
http://purl.org/obo/owl/CORUM#CORUM_2987
A protein complex that contains the mTOR (mammalian target of rapamycin) serine/threonine kinase, the peptidyl-prolyl cis-trans isomerase FKBP12 (FKBP1A) and rapamycin (sirolimus).
PMID:20005306
http://purl.org/obo/owl/PMID#PMID_20005306
PMID:7822316
http://purl.org/obo/owl/PMID#PMID_7822316
GOC:sl
http://purl.org/obo/owl/GOC#GOC_sl
Mad-Max-mSin3A complex
cellular_component
A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3A, a homolog of the yeast Sin3p.
PMID:7889570
http://purl.org/obo/owl/PMID#PMID_7889570
Mad-Max-mSin3B complex
cellular_component
A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3B, a homolog of the yeast Sin3p.
PMID:7889570
http://purl.org/obo/owl/PMID#PMID_7889570
G-protein beta/gamma-Btk complex
See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'.
cellular_component
G protein complex (BTK, GNG1, GNG2)
CORUM:1615
http://purl.org/obo/owl/CORUM#CORUM_1615
G protein complex (Btk, Gng2, Gnb1)
CORUM:3195
http://purl.org/obo/owl/CORUM#CORUM_3195
A protein complex formed by the association of the Bruton tyrosine protein kinase Btk, which is implicated in mammalian X-linked immunodeficiencies, with the beta and gamma subunits of a heterotrimeric G protein.
PMID:7972043
http://purl.org/obo/owl/PMID#PMID_7972043
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
alphaIIb-beta3 integrin complex
cellular_component
ITGA2B-ITGB3 complex
CORUM:2381
http://purl.org/obo/owl/CORUM#CORUM_2381
An integrin complex that comprises one alphaIIb subunit and one beta3 subunit.
PMID:12297042
http://purl.org/obo/owl/PMID#PMID_12297042
Mad-Max complex
cellular_component
A transcriptional repressor complex that consists of a heterodimer of the bHLH-ZIP proteins Mad and Max.
PMID:8224841
http://purl.org/obo/owl/PMID#PMID_8224841
elongin complex
See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'.
cellular_component
A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (abut 100 kDa)and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa)subunits.
PMID:12676794
http://purl.org/obo/owl/PMID#PMID_12676794
transcription elongation factor SIII complex
PMID:8244996
http://purl.org/obo/owl/PMID#PMID_8244996
elongin (SIII) complex
CORUM:56
http://purl.org/obo/owl/CORUM#CORUM_56
interleukin4-interleukin-4 receptor complex
cellular_component
IL4-IL4R-IL2RG complex
CORUM:1515
http://purl.org/obo/owl/CORUM#CORUM_1515
A protein complex that is formed by the association of a heterodimeric interleukin-4 receptor complex with an interleukin-4 molecule.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:10358772
http://purl.org/obo/owl/PMID#PMID_10358772
IL4-IL4 receptor complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cell hair
cellular_component
imaginal disc-derived wing hair
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Wikipedia:Membrane_nanotube
http://purl.org/obo/owl/Wikipedia#Wikipedia_Membrane_nanotube
A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located.
PMID:11526084
http://purl.org/obo/owl/PMID#PMID_11526084
non-sensory hair
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
SAGA-type complex
cellular_component
A histone acetyltransferase complex that acetylates nucleosomal H3 and H2B and is required for the expression of a subset of Pol II-transcribed genes. The budding yeast complex includes the acetyltransferase Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:10637607
http://purl.org/obo/owl/PMID#PMID_10637607
PMID:17337012
http://purl.org/obo/owl/PMID#PMID_17337012
SAGA family complex
PMID:17337012
http://purl.org/obo/owl/PMID#PMID_17337012
alphav-beta3 integrin-collagen alpha3(VI) complex
cellular_component
A protein complex that consists of an alphav-beta3 integrin complex bound to the alpha3 chain of type VI collagen; the integrin binds most strongly to unfolded collagen.
PMID:8387021
http://purl.org/obo/owl/PMID#PMID_8387021
alpha1-beta1 integrin-alpha3(VI) complex
cellular_component
A protein complex that consists of an alpha1-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain.
PMID:8387021
http://purl.org/obo/owl/PMID#PMID_8387021
ITGA1-ITGB1-COL6A3 complex
CORUM:2434
http://purl.org/obo/owl/CORUM#CORUM_2434
alpha2-beta1 integrin-alpha3(VI) complex
cellular_component
ITGA2-ITGB1-COL6A3 complex
CORUM:2431
http://purl.org/obo/owl/CORUM#CORUM_2431
A protein complex that consists of an alpha2-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain.
PMID:8387021
http://purl.org/obo/owl/PMID#PMID_8387021
RC-1 DNA recombination complex
cellular_component
A protein complex that contains DNA ligase III, DNA polymerase epsilon, a 5'-3' exonuclease, and the SMC1 and SMC2 proteins, and is involved in recombinational repair of deletions and gaps in DNA.
PMID:8392064
http://purl.org/obo/owl/PMID#PMID_8392064
PMID:8670910
http://purl.org/obo/owl/PMID#PMID_8670910
DNA recombination complex RC-1
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
RC-1 complex (recombination complex 1)
CORUM:364
http://purl.org/obo/owl/CORUM#CORUM_364
respiratory chain
cellular_component
membrane electron transport chain
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
plasma membrane respiratory chain
cellular_component
plasma membrane electron transport chain
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A respiratory chain located in the plasma membrane of a cell; made up of the protein complexes that form the electron transport system (the respiratory chain), associated with the plasma membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.
ISBN:0198547684
http://purl.org/obo/owl/ISBN#ISBN_0198547684
GOC:imk
http://purl.org/obo/owl/GOC#GOC_imk
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
endospore core
cellular_component
An intracellular part that represents the innermost portion of an endospore; the endospore core is dehydrated, enriched in dipicolinic acid and divalent cations, and metabolically inactive.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:15035041
http://purl.org/obo/owl/PMID#PMID_15035041
PMID:18035610
http://purl.org/obo/owl/PMID#PMID_18035610
pollen coat
cellular_component
pollenkitt
PMID:15012271
http://purl.org/obo/owl/PMID#PMID_15012271
A layer of extracellular matrix deposited onto the surface of the pollen wall upon disintegration of the tapetal layer of the anther wall in the late stages of pollen development. The composition of this material is highly heterogeneous and includes waxes, lipid droplets, small aromatic molecules, and proteins. The pollen coat is proposed to have many functions, such as holding pollen in the anther until dispersal, facilitation of pollen dispersal, protection of pollen from water loss and UV radiation, and facilitation of adhesion of pollen to the stigma.
PMID:15012271
http://purl.org/obo/owl/PMID#PMID_15012271
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
PMID:12930826
http://purl.org/obo/owl/PMID#PMID_12930826
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
tryphine
PMID:15012271
http://purl.org/obo/owl/PMID#PMID_15012271
SRF-myogenin-E12 complex
cellular_component
A transcription factor complex that contains the serum response factor (SRF) and the basic helix-loop-helix proteins myogenin and E12, and is involved in activating transcription of muscle-specific genes.
PMID:8617811
http://purl.org/obo/owl/PMID#PMID_8617811
alphaIIb-beta3 integrin-talin complex
cellular_component
ITGA2b-ITGB3-TLN1 complex
CORUM:2378
http://purl.org/obo/owl/CORUM#CORUM_2378
A protein complex that consists of an alphaIIb-beta3 integrin complex bound to talin.
PMID:8663236
http://purl.org/obo/owl/PMID#PMID_8663236
CAK-ERCC2 complex
cellular_component
cyclin-dependent protein kinase activating kinase holoenzyme-ERCC2 complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2.
PMID:8692842
http://purl.org/obo/owl/PMID#PMID_8692842
PMID:8692841
http://purl.org/obo/owl/PMID#PMID_8692841
DNA replication factor C core complex
cellular_component
RFC core complex
CORUM:278
http://purl.org/obo/owl/CORUM#CORUM_278
A protein complex containing three of the five subunits of eukaryotic replication factor C, those corresponding to human p40, p38, and p37.
PMID:9582326
http://purl.org/obo/owl/PMID#PMID_9582326
PMID:9228079
http://purl.org/obo/owl/PMID#PMID_9228079
PMID:8692848
http://purl.org/obo/owl/PMID#PMID_8692848
alpha4-beta1 integrin-CD53 complex
cellular_component
ITGA4-ITGB1-CD53 complex
CORUM:2420
http://purl.org/obo/owl/CORUM#CORUM_2420
A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD53, a member of the tetraspan family.
PMID:8757325
http://purl.org/obo/owl/PMID#PMID_8757325
alpha4-beta1 integrin-CD63 complex
cellular_component
A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD63, a member of the tetraspan family.
PMID:8757325
http://purl.org/obo/owl/PMID#PMID_8757325
ITGA4-ITGB1-CD63 complex
CORUM:2424
http://purl.org/obo/owl/CORUM#CORUM_2424
alpha4-beta1 integrin-CD81 complex
cellular_component
A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD81, a member of the tetraspan family.
PMID:8757325
http://purl.org/obo/owl/PMID#PMID_8757325
PMID:10229664
http://purl.org/obo/owl/PMID#PMID_10229664
ITGA4-ITGB1-CD81 complex
CORUM:2419
http://purl.org/obo/owl/CORUM#CORUM_2419
alpha4-beta1 integrin-CD82 complex
cellular_component
A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD82, a member of the tetraspan family.
PMID:8757325
http://purl.org/obo/owl/PMID#PMID_8757325
ERCC4-ERCC1 complex
Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
cellular_component
Rad1-Rad10 complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA lesions. The subunits are known as XPF/ERCC4 and ERCC1 in mammals, and Rad1p and Rad10p in S. cerevisiae.
PMID:14734547
http://purl.org/obo/owl/PMID#PMID_14734547
XPF-ERCC1 complex
PMID:14734547
http://purl.org/obo/owl/PMID#PMID_14734547
BRCA1-A complex
cellular_component
A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites.
PMID:19261749
http://purl.org/obo/owl/PMID#PMID_19261749
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
BRCA1-B complex
cellular_component
A protein complex that contains the BRCA1-BARD1 heterodimer, BACH1 and TopBP1, and binds to DNA during S phase at DNA damage sites.
PMID:16391231
http://purl.org/obo/owl/PMID#PMID_16391231
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
BRCA1-C complex
cellular_component
A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint.
PMID:15485915
http://purl.org/obo/owl/PMID#PMID_15485915
PMID:16391231
http://purl.org/obo/owl/PMID#PMID_16391231
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PeBoW complex
cellular_component
A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively.
PMID:17353269
http://purl.org/obo/owl/PMID#PMID_17353269
PMID:16043514
http://purl.org/obo/owl/PMID#PMID_16043514
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
BRISC complex
cellular_component
A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:19214193
http://purl.org/obo/owl/PMID#PMID_19214193
synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex
cellular_component
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 3, and a complexin (or orthologs thereof).
PMID:8824312
http://purl.org/obo/owl/PMID#PMID_8824312
Stx3-Snap25-Vamp2-Cplx1 complex
CORUM:842
http://purl.org/obo/owl/CORUM#CORUM_842
SNARE complex (Stx3, Snap25, Vamp2, Cplx1)
CORUM:842
http://purl.org/obo/owl/CORUM#CORUM_842
TAF4B-containing transcription factor TFIID complex
cellular_component
A transcription factor TFIID complex that contains the TBP-associated factor TAF4B (also known as TAFII105 in human), a cell-type-specific variant of TAF4.
PMID:8858156
http://purl.org/obo/owl/PMID#PMID_8858156
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
TFIID complex, B-cell specific
CORUM:485
http://purl.org/obo/owl/CORUM#CORUM_485
PCNA-p21 complex
cellular_component
A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication.
PMID:7911228
http://purl.org/obo/owl/PMID#PMID_7911228
PMID:7915843
http://purl.org/obo/owl/PMID#PMID_7915843
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
alphaM-beta2 integrin-CD63 complex
cellular_component
ITGAM-ITGB2-CD63 complex
CORUM:2153
http://purl.org/obo/owl/CORUM#CORUM_2153
A protein complex that consists of an alphaM-beta2 integrin complex bound to membrane protein CD63, a member of the tetraspan family.
PMID:8871662
http://purl.org/obo/owl/PMID#PMID_8871662
lysosomal multienzyme complex
cellular_component
A protein complex found in the lysosome that contains beta-galactosidase, cathepsin A, alpha-neuraminidase and N-acetylgalactosamine-6-sulfate sulfatase, and is involved in glycosaminoglycan catabolism.
PMID:8910459
http://purl.org/obo/owl/PMID#PMID_8910459
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GALNS-lysosomal hydrolase 1.27 MDa complex
CORUM:1379
http://purl.org/obo/owl/CORUM#CORUM_1379
telomere-telomerase complex
Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome.
cellular_component
A complex of DNA and protein located at the end of a linear chromosome that enables replication of the telomeric repeat sequences at the end of a linear chromosome.
GOC:pde
http://purl.org/obo/owl/GOC#GOC_pde
PMID:19179534
http://purl.org/obo/owl/PMID#PMID_19179534
RISC-loading complex
cellular_component
A trimeric ribonucleoprotein complex that and is required for the formation of a mature RNA induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1) and TRBP (TARBP2) in association with the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP.
PMID:18178619
http://purl.org/obo/owl/PMID#PMID_18178619
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
RLC
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
microRNA loading complex
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
miRLC
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
SWI/SNF-type complex
cellular_component
A chromatin remodeling complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the core components.
PMID:16155938
http://purl.org/obo/owl/PMID#PMID_16155938
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
SWI-SNF global transcription activator complex
CORUM:224
http://purl.org/obo/owl/CORUM#CORUM_224
SWI-SNF-type complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PBAF complex
cellular_component
A SWI/SNF-type complex that contains the ATPase product of the mammalian BAF180 gene.
PMID:8895581
http://purl.org/obo/owl/PMID#PMID_8895581
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:16155938
http://purl.org/obo/owl/PMID#PMID_16155938
SWI/SNF complex B
CORUM:565
http://purl.org/obo/owl/CORUM#CORUM_565
Polybromo- and BAF containing complex
CORUM:565
http://purl.org/obo/owl/CORUM#CORUM_565
Grb2-Sos complex
cellular_component
Grb2-mSos1 complex
CORUM:2545
http://purl.org/obo/owl/CORUM#CORUM_2545
A protein complex that contains Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.
PMID:7798267
http://purl.org/obo/owl/PMID#PMID_7798267
PMID:8940013
http://purl.org/obo/owl/PMID#PMID_8940013
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Shc-Grb2-Sos complex
cellular_component
A protein complex that contains Grb2, the adaptor protein Shc and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.
PMID:7970708
http://purl.org/obo/owl/PMID#PMID_7970708
PMID:8940013
http://purl.org/obo/owl/PMID#PMID_8940013
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Shc-Grb2-mSos1 complex, EGF stimulated
CORUM:2553
http://purl.org/obo/owl/CORUM#CORUM_2553
EGFR-Grb2-Sos complex
cellular_component
Egfr-Grb2-mSos1 complex, EGF stimulated
CORUM:2548
http://purl.org/obo/owl/CORUM#CORUM_2548
A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.
PMID:8940013
http://purl.org/obo/owl/PMID#PMID_8940013
PMID:7798267
http://purl.org/obo/owl/PMID#PMID_7798267
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
EGFR-Shc-Grb2-Sos complex
cellular_component
A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2, the adaptor protein SHC and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:7798267
http://purl.org/obo/owl/PMID#PMID_7798267
PMID:8940013
http://purl.org/obo/owl/PMID#PMID_8940013
UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex
cellular_component
A protein complex that possesses UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity; the bovine complex contains disulfide-linked homodimers of 166- and 51-kDa subunits and two identical, noncovalently associated 56-kDa subunits.
PMID:8940155
http://purl.org/obo/owl/PMID#PMID_8940155
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
N-acetylglucosamine-1-phosphotransferase complex
CORUM:406
http://purl.org/obo/owl/CORUM#CORUM_406
UDP-N-acetylglucosamine:lysosomal-enzyme N-acetylglucosamine-1-phosphotransferase complex
PMID:8940155
http://purl.org/obo/owl/PMID#PMID_8940155
Ubisch body
cellular_component
orbicule
PMID:14612572
http://purl.org/obo/owl/PMID#PMID_14612572
A small, granular structure that is found in the extracellular matrix of cell of the secretory tapetal layer that surrounds developing pollen grains. Ubisch bodies have a sporopollenin coat, are attached to the peritapetal wall, and may play a role in pollen development.
PMID:16524248
http://purl.org/obo/owl/PMID#PMID_16524248
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
PMID:14612572
http://purl.org/obo/owl/PMID#PMID_14612572
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
formin-nucleated actin cable
cellular_component
An actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. In fungal cells, myosin motors transport cargo along actin cables toward sites of polarized cell growth; actin cables may play a similar role in pollen tube growth.
PMID:14671023
http://purl.org/obo/owl/PMID#PMID_14671023
PMID:16959963
http://purl.org/obo/owl/PMID#PMID_16959963
HAUS complex
cellular_component
HAUS augmin complex
GOC:mm2
http://purl.org/obo/owl/GOC#GOC_mm2
A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex.
PMID:19427217
http://purl.org/obo/owl/PMID#PMID_19427217
macropinocytic cup
cellular_component
crown
PMID:9044041
http://purl.org/obo/owl/PMID#PMID_9044041
GOC:pf
http://purl.org/obo/owl/GOC#GOC_pf
A cell projection that forms at the site of macropinocytosis, a form of endocytosis that results in the uptake of relatively large amounts of extracellular fluid. The macropinocytic cup membrane selectively excludes certain proteins, such as H36 or PM4C4 in Dictyostelium, and the underlying cytoskeleton is enriched in F-actin and coronin.
PMID:9044041
http://purl.org/obo/owl/PMID#PMID_9044041
PMID:16968738
http://purl.org/obo/owl/PMID#PMID_16968738
PMID:12538772
http://purl.org/obo/owl/PMID#PMID_12538772
macropinocytic cup membrane
cellular_component
crown membrane
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
The portion of the plasma membrane surrounding a macropinocytic cup.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
macropinocytic cup cytoskeleton
cellular_component
The part of the cortical actin cytoskeleton that forms part of a macropinocytic cup.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
crown cytoskeleton
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
MLL5-L complex
cellular_component
A protein complex that can methylate lysine-4 of histone H3 and plays an essential role in retinoic-acid-induced granulopoiesis. MLL5 is the catalytic methyltransferase subunit, and the complex also contains serine/threonine kinase 38 (STK38), protein phosphatase 1 catalytic subunits, the host cell factor-1 N-terminal subunit, beta-actin, and O-GlcNAc transferase; the human genes encoding the subunits are MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT, respectively.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:19377461
http://purl.org/obo/owl/PMID#PMID_19377461
dimeric positive transcription elongation factor complex b
cellular_component
Sgv1/Bur2 complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A positive transcription elongation factor complex b that comprises two subunits; an example is the budding yeast complex containing Svg1p (also called Bur1p) and Bur2p.
PMID:19328067
http://purl.org/obo/owl/PMID#PMID_19328067
PMID:16721054
http://purl.org/obo/owl/PMID#PMID_16721054
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Bur1/Bur2 complex
PMID:19328067
http://purl.org/obo/owl/PMID#PMID_19328067
PMID:16721054
http://purl.org/obo/owl/PMID#PMID_16721054
trimeric positive transcription elongation factor complex b
cellular_component
CTDK-I complex
PMID:19328067
http://purl.org/obo/owl/PMID#PMID_19328067
PMID:16721054
http://purl.org/obo/owl/PMID#PMID_16721054
A positive transcription elongation factor complex b that comprises three subunits; an example is the budding yeast Ctk complex, which consists of Ctk1p, Ctk2p and Ctk3p.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:16721054
http://purl.org/obo/owl/PMID#PMID_16721054
PMID:19328067
http://purl.org/obo/owl/PMID#PMID_19328067
Ctk complex
PMID:16721054
http://purl.org/obo/owl/PMID#PMID_16721054
P-TEFb-cap methyltransferase complex
cellular_component
A protein complex that is formed by the association of positive transcription elongation factor complex b (P-TEFb) with the mRNA capping methyltransferase.
PMID:17332744
http://purl.org/obo/owl/PMID#PMID_17332744
PMID:19328067
http://purl.org/obo/owl/PMID#PMID_19328067
Cdk9-Pcm1 complex
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
P-TEFb-Pcm1 complex
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
FHF complex
Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
cellular_component
A protein complex that is composed of AKTIP/FTS, FAM160A2/p107FHIP, and one or more members of the Hook family of proteins, HOOK1, HOOK2, and HOOK3. The complex is thought to promote vesicle trafficking and/or fusion, and associates with the homotypic vesicular sorting complex (the HOPS complex).
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:18799622
http://purl.org/obo/owl/PMID#PMID_18799622
mucus layer
cellular_component
An extracellular region part that consists of a protective layer of mucus secreted by epithelial cells lining tubular organs of the body such as the colon. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes.
GOC:mm2
http://purl.org/obo/owl/GOC#GOC_mm2
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:19432394
http://purl.org/obo/owl/PMID#PMID_19432394
PMID:18806221
http://purl.org/obo/owl/PMID#PMID_18806221
inner mucus layer
cellular_component
The inner of two mucus layers secreted by epithelial cells in the colon; the inner mucus layer is firmly attached to the epithelium, is densely packed with a compact stratified appearance and is devoid of bacteria.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:mm2
http://purl.org/obo/owl/GOC#GOC_mm2
PMID:18806221
http://purl.org/obo/owl/PMID#PMID_18806221
PMID:19432394
http://purl.org/obo/owl/PMID#PMID_19432394
outer mucus layer
cellular_component
The outer of two mucus layers secreted by epithelial cells in the colon; the outer mucus layer is loosely packed and can be colonized by bacteria.
PMID:19432394
http://purl.org/obo/owl/PMID#PMID_19432394
PMID:18806221
http://purl.org/obo/owl/PMID#PMID_18806221
GOC:mm2
http://purl.org/obo/owl/GOC#GOC_mm2
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
alphaPDGFR-SHP-2 complex
cellular_component
A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:8943348
http://purl.org/obo/owl/PMID#PMID_8943348
PDGFRA-SHP-2 complex, PDGF stimulated
CORUM:3183
http://purl.org/obo/owl/CORUM#CORUM_3183
alphaPDGFR-PLC-gamma-1-PI3K-SHP-2 complex
cellular_component
A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA), phospholipase C-gamma-1 (PLC-gamma-1), phosphatidylinositol 3-kinase (PI3K) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway.
PMID:8943348
http://purl.org/obo/owl/PMID#PMID_8943348
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated
CORUM:2551
http://purl.org/obo/owl/CORUM#CORUM_2551
Grb2-SHP-2 complex
cellular_component
GRB2-SHP-2 complex, PDGF stimulated
CORUM:3186
http://purl.org/obo/owl/CORUM#CORUM_3186
A protein complex that contains the receptor adaptor proteins Grb2 and SHP-2, and is involved signaling via the PDGFR signaling pathway.
PMID:8943348
http://purl.org/obo/owl/PMID#PMID_8943348
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISGF3 complex
cellular_component
A transcription factor complex that consists of a Stat1-Stat2 heterodimer and the IRF9 protein.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:8943351
http://purl.org/obo/owl/PMID#PMID_8943351
interferon-stimulated gene factor 3 transcription complex
CORUM:60
http://purl.org/obo/owl/CORUM#CORUM_60
Tle3-Aes complex
cellular_component
A transcriptional repressor complex that consists of a heterodimer of the proteins Tle3 (also known as Grg3b) and Aes (Grg5), which are homologs of the Drosophila groucho gene product.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:8955148
http://purl.org/obo/owl/PMID#PMID_8955148
Grg3b-Grg5 complex
CORUM:3130
http://purl.org/obo/owl/CORUM#CORUM_3130
PMID:8955148
http://purl.org/obo/owl/PMID#PMID_8955148
BMP receptor complex
cellular_component
bone morphogenetic protein receptor complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A protein complex that acts as a receptor for bone morphogenetic proteins (BMPs); a homo- or heterodimer of type I and/or type II BMP receptor subunits.
GOC:mh
http://purl.org/obo/owl/GOC#GOC_mh
PMID:19377468
http://purl.org/obo/owl/PMID#PMID_19377468
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Yb body
cellular_component
A cytoplasmic part that appears as an electron-dense sphere of around 1.5 micron diameter containing Yb protein found in somatic cells of ovary and testis. There are one to two Yb bodies per cell.
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
PMID:19433453
http://purl.org/obo/owl/PMID#PMID_19433453
spindle envelope
cellular_component
An organelle envelope that surrounds the chromosomes and the central part of the spindle apparatus during mitosis and meiosis; observed in many invertebrates. The spindle envelope consists of membrane layers, called parafusorial membranes, derived from endoplasmic reticulum membrane; in male meiosis it forms during prometaphase and persists until early in the ensuing interphase.
PMID:6428889
http://purl.org/obo/owl/PMID#PMID_6428889
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
PMID:19417004
http://purl.org/obo/owl/PMID#PMID_19417004
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
interleukin-23 complex
Note that this heterodimeric cytokine utilizes the same beta subunit as IL-12.
cellular_component
IL-23 complex
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
PMID:11114383
http://purl.org/obo/owl/PMID#PMID_11114383
PMID:15999093
http://purl.org/obo/owl/PMID#PMID_15999093
IL12B
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IL23A
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
p19
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
p40
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
interleukin-27 complex
Note that this heterodimeric cytokine utilizes the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-35 uses for its beta chain. Also note that the product of the IL27 gene is the alpha subunit of IL-27. The functional IL-27 protein complex requires both subunits.
cellular_component
A protein complex that is composed of an interleukin-27p28 subunit (product of the IL27 gene) and an EBI3 subunit and is secreted into the extracellular space.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
PMID:15999093
http://purl.org/obo/owl/PMID#PMID_15999093
PMID:19161428
http://purl.org/obo/owl/PMID#PMID_19161428
p28
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IL-27 complex
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IL27
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
EBI3
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
interleukin-35 complex
Note that this heterodimeric cytokine utilizes the same IL-12p35 subunit as its alpha chain as IL-12 uses and the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-27 uses. IL-35 requires both subunits -- there is no separate IL35 gene.
cellular_component
IL-35 complex
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
EBI3
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IL12A
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A protein complex that is composed of an interleukin-12 alpha subunit (p35, product of the IL12A gene) and an EBI3 subunit and is secreted into the extracellular space.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
PMID:19161429
http://purl.org/obo/owl/PMID#PMID_19161429
PMID:19161428
http://purl.org/obo/owl/PMID#PMID_19161428
p35
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
pre-snoRNP complex
cellular_component
pre-small nucleolar ribonucleoprotein complex
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes.
PMID:17636026
http://purl.org/obo/owl/PMID#PMID_17636026
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
PMID:17709390
http://purl.org/obo/owl/PMID#PMID_17709390
NDC1 complex
cellular_component
NDC1 subcomplex
PMID:19414609
http://purl.org/obo/owl/PMID#PMID_19414609
A protein complex that forms part of the nuclear pore complex, and contains three transmembrane nucleoporins, encoded in S. cerevisiae by Ndc1p, Pom152p and Pom34p.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:19414609
http://purl.org/obo/owl/PMID#PMID_19414609
Delta1 complex
cellular_component
A protein complex that consists of homodimer of the Notch ligand Delta1.
PMID:12794186
http://purl.org/obo/owl/PMID#PMID_12794186
Delta1 homodimer complex
CORUM:3271
http://purl.org/obo/owl/CORUM#CORUM_3271
gamma-secretase-Delta1 complex
cellular_component
A protein complex that is formed by the association of the Notch ligand Delta1 with the gamma-secretase complex.
PMID:12794186
http://purl.org/obo/owl/PMID#PMID_12794186
gamma-secretase complex
cellular_component
gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN)
CORUM:468
http://purl.org/obo/owl/CORUM#CORUM_468
A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein.
PMID:17047368
http://purl.org/obo/owl/PMID#PMID_17047368
PMID:15890777
http://purl.org/obo/owl/PMID#PMID_15890777
PMID:15286082
http://purl.org/obo/owl/PMID#PMID_15286082
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)
CORUM:3128
http://purl.org/obo/owl/CORUM#CORUM_3128
gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)
CORUM:467
http://purl.org/obo/owl/CORUM#CORUM_467
gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant)
CORUM:130
http://purl.org/obo/owl/CORUM#CORUM_130
CORUM:45
http://purl.org/obo/owl/CORUM#CORUM_45
CORUM:466
http://purl.org/obo/owl/CORUM#CORUM_466
CORUM:2891
http://purl.org/obo/owl/CORUM#CORUM_2891
CORUM:43
http://purl.org/obo/owl/CORUM#CORUM_43
CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant)
CORUM:142
http://purl.org/obo/owl/CORUM#CORUM_142
endobrevin-synaptobrevin 2-alpha-SNAP-NSF-syntaxin-4 complex
cellular_component
A SNARE complex that contains endobrevin (VAMP8), synaptobrevin 2 (VAMP2), alpha-SNAP, NSF, and syntaxin 4 (or orthologs thereof).
PMID:8973549
http://purl.org/obo/owl/PMID#PMID_8973549
Stx4-Napa-Vamp3-Nsf-Vamp2 complex
CORUM:1876
http://purl.org/obo/owl/CORUM#CORUM_1876
SNARE complex (Stx4, Napa, Vamp3, Nsf, Vamp2)
CORUM:1876
http://purl.org/obo/owl/CORUM#CORUM_1876
BRCA1-Rad51 complex
cellular_component
A protein complex that contains BRCA1 and Rad 51, and is involved in the control of recombination and of genome integrity.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:9008167
http://purl.org/obo/owl/PMID#PMID_9008167
synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Unc13 complex
cellular_component
A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Unc13b (or orthologs thereof).
PMID:8999968
http://purl.org/obo/owl/PMID#PMID_8999968
Snap25-Syt1-Unc13b-Vamp2-Stx1b2-Stx1a complex
CORUM:1873
http://purl.org/obo/owl/CORUM#CORUM_1873
SNARE complex (Snap25, Syt1, Unc13b, Vamp2, Stx1b2, Stx1a)
CORUM:1873
http://purl.org/obo/owl/CORUM#CORUM_1873
alphaIIb-beta3 integrin-CIB complex
cellular_component
A protein complex that consists of an alphaIIb-beta3 integrin complex bound to CIB, a protein that binds calcium as well as the alphaIIb-beta3 integrin.
PMID:9030514
http://purl.org/obo/owl/PMID#PMID_9030514
ITGA2B-ITGB3-CIB1 complex
CORUM:2379
http://purl.org/obo/owl/CORUM#CORUM_2379
alphaIIb-beta3 integrin-CD47-FAK complex
cellular_component
ITGA2b-ITGB3-CD47-FAK complex
CORUM:2896
http://purl.org/obo/owl/CORUM#CORUM_2896
A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase FAK.
PMID:9169439
http://purl.org/obo/owl/PMID#PMID_9169439
alphaIIb-beta3 integrin-CD47-Src complex
cellular_component
A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase c-Src.
PMID:9169439
http://purl.org/obo/owl/PMID#PMID_9169439
ITGA2b-ITGB3-CD47-SRC complex
CORUM:2377
http://purl.org/obo/owl/CORUM#CORUM_2377
PAS complex
cellular_component
A protein complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.
PMID:19037259
http://purl.org/obo/owl/PMID#PMID_19037259
PMID:19158662
http://purl.org/obo/owl/PMID#PMID_19158662
PMID:18950639
http://purl.org/obo/owl/PMID#PMID_18950639
H3 histone acetyltransferase complex
cellular_component
A multisubunit complex that catalyzes the acetylation of histone H3.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
H3 HAT complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
MOZ/MORF histone acetyltransferase complex
cellular_component
A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.
PMID:18794358
http://purl.org/obo/owl/PMID#PMID_18794358
tertiary granule
cellular_component
A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
PMID:12070036
http://purl.org/obo/owl/PMID#PMID_12070036
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
tertiary granule membrane
cellular_component
The lipid bilayer surrounding a tertiary granule.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:12070036
http://purl.org/obo/owl/PMID#PMID_12070036
GOC:rl
http://purl.org/obo/owl/GOC#GOC_rl
Sin3-type complex
cellular_component
Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex.
PMID:18292778
http://purl.org/obo/owl/PMID#PMID_18292778
PMID:15565322
http://purl.org/obo/owl/PMID#PMID_15565322
HDA1 complex
cellular_component
A tetrameric histone deacetylase complex that contains a Class II deacetylase catalytic subunit. In S. cerevisiae it is composed of two Hda1p subunits along with Hda2p and Hda3p.
GOC:dgf
http://purl.org/obo/owl/GOC#GOC_dgf
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:11287668
http://purl.org/obo/owl/PMID#PMID_11287668
PMID:8663039
http://purl.org/obo/owl/PMID#PMID_8663039
SHREC complex
cellular_component
A histone deacetylase complex that contains a core of four proteins -- Clr1, Clr2, Clr3, and Mit1 in fission yeast -- and localizes to all heterochromatic regions in the genome as well as some euchromatic sites. The complex is involved in regulating nucleosome positioning to assemble higher-order chromatin structures.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:17289569
http://purl.org/obo/owl/PMID#PMID_17289569
micropyle
cellular_component
An external encapsulating structure part of the chorion. A single cone-shaped specialization that forms an opening in the chorion that allows sperm entry into the egg prior to fertilization.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:18649270
http://purl.org/obo/owl/PMID#PMID_18649270
GOC:cvs
http://purl.org/obo/owl/GOC#GOC_cvs
paraferritin complex
cellular_component
A cytoplasmic protein complex that contains integrin, mobilferrin and a flavin monooxygenase, is capable of reducing Fe(III) to Fe(II) utilizing NADPH, and is involved in iron transport. Fe(II) is required in the cell as the substrate for ferrochelatase in the synthesis of heme.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:11842004
http://purl.org/obo/owl/PMID#PMID_11842004
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
PMID:8639593
http://purl.org/obo/owl/PMID#PMID_8639593
core mediator complex
cellular_component
C mediator complex
PMID:17870225
http://purl.org/obo/owl/PMID#PMID_17870225
S mediator complex
PMID:17043218
http://purl.org/obo/owl/PMID#PMID_17043218
A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
PMID:11454195
http://purl.org/obo/owl/PMID#PMID_11454195
PMID:16168358
http://purl.org/obo/owl/PMID#PMID_16168358
PMID:17870225
http://purl.org/obo/owl/PMID#PMID_17870225
TACC/TOG complex
cellular_component
A protein complex that contains the transforming acidic coiled coil (TACC) protein and the TOG protein (Mia1p/Alp7p and Alp14, respectively, in fission yeast), and is involved in microtubule array remodeling as cells progress through the cell cycle. The TACC/TOG complex is conserved in eukaryotes, associates with microtubules, and shuttles between the nucleus and the cytoplasm during interphase.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:19606211
http://purl.org/obo/owl/PMID#PMID_19606211
cell body fiber
cellular_component
A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches.
GOC:dos
http://purl.org/obo/owl/GOC#GOC_dos
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
primary neurite
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:dos
http://purl.org/obo/owl/GOC#GOC_dos
cell body fibre
RNA polymerase I core factor complex
Note that, although this complex can be considered analogous to the mammalian transcription factor SL complex, the core factor complex does not include TBP, whereas SL1 does.
cellular_component
A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p.
PMID:8702872
http://purl.org/obo/owl/PMID#PMID_8702872
sperm individualization complex
cellular_component
A macromolecular complex that cytoskeletal components and part of the cell membrane, forms at the nuclear end of a male germline syncytium, or cyst, and translocates the over the length of the syncytium in the course of sperm individualization. Each complex contains an array of 64 investment cones, one per nucleus, that move synchronously along the spermatogenic cyst.
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
PMID:10588662
http://purl.org/obo/owl/PMID#PMID_10588662
PMID:9550716
http://purl.org/obo/owl/PMID#PMID_9550716
investment cone
cellular_component
A cytoskeletal part that consists of a microfilament-rich cone that forms round each nucleus in a spermatogenic cyst and translocates the length of the cyst during sperm individualization.
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
PMID:15829565
http://purl.org/obo/owl/PMID#PMID_15829565
PMID:9550716
http://purl.org/obo/owl/PMID#PMID_9550716
F-actin cone
PMID:15829565
http://purl.org/obo/owl/PMID#PMID_15829565
mating projection tip membrane
cellular_component
The portion of the plasma membrane surrounding a mating projection tip.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
SOSS complex
cellular_component
A protein complex that functions downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and is composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80.
PMID:19683501
http://purl.org/obo/owl/PMID#PMID_19683501
microprocessor complex
cellular_component
A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs.
PMID:16963499
http://purl.org/obo/owl/PMID#PMID_16963499
PMID:17159994
http://purl.org/obo/owl/PMID#PMID_17159994
Ddb1-Ckn1 complex
cellular_component
A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Ckn1 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases.
PMID:18794354
http://purl.org/obo/owl/PMID#PMID_18794354
Ddb1-Wdr21 complex
cellular_component
A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Wdr21 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases.
PMID:18794354
http://purl.org/obo/owl/PMID#PMID_18794354
inositol phosphoceramide synthase complex
cellular_component
IPC synthase complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A protein complex that possesses inositol phosphoceramide synthase activity and contains a catalytic subunit and a regulatory subunit (Aur1p and Kei1p, respectively, in Saccharomyces).
PMID:19726565
http://purl.org/obo/owl/PMID#PMID_19726565
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Golgi-associated vesicle lumen
cellular_component
The volume enclosed by the membrane of a Golgi-associated vesicle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
CRD-mediated mRNA stability complex
See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'.
cellular_component
A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, IGF2BP1 and at least four additional proteins: HNRNPU, SYNCRIP, YBX1, and DHX9.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:19029303
http://purl.org/obo/owl/PMID#PMID_19029303
contractile ring
cellular_component
constriction ring
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
cytokinetic ring
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0123645859
http://purl.org/obo/owl/ISBN#ISBN_0123645859
ISBN:0792354923
http://purl.org/obo/owl/ISBN#ISBN_0792354923
PMID:10791428
http://purl.org/obo/owl/PMID#PMID_10791428
PMID:17913889
http://purl.org/obo/owl/PMID#PMID_17913889
Dsl1p complex
See also the molecular function term 'acetolactate synthase activity ; GO:0003984'.
cellular_component
A multisubunit tethering complex, i.e. a protein complex involved in mediating the initial interaction between vesicles and the membranes with which they fuse, that is involved in trafficking from the Golgi apparatus to the ER. In Saccharomyces cerevisiae the Dsl1p complex contains Dsl1p, Tip20p, and Sec39p.
PMID:19151722
http://purl.org/obo/owl/PMID#PMID_19151722
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:jh
http://purl.org/obo/owl/GOC#GOC_jh
ULK1-ATG13-FIP200 complex
cellular_component
ULK1-ATG13-RB1CC1 complex
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
A protein complex that is essential for mammalian autophagy, and consists of at least 3 proteins: ULK1, ATG13 and RB1CC1(FIP200). This complex is the mammalian counterpart of Atg1-Atg13-Atg17 in yeast.
PMID:19211835
http://purl.org/obo/owl/PMID#PMID_19211835
PMID:19258318
http://purl.org/obo/owl/PMID#PMID_19258318
PMID:19597335
http://purl.org/obo/owl/PMID#PMID_19597335
endoplasmic reticulum exit site
cellular_component
ER exit site
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
An endoplasmic reticulum part at which COPII-coated vesicles are produced.
PMID:15623529
http://purl.org/obo/owl/PMID#PMID_15623529
PMID:16957052
http://purl.org/obo/owl/PMID#PMID_16957052
transitional ER
PMID:15623529
http://purl.org/obo/owl/PMID#PMID_15623529
TFIIK complex
cellular_component
A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces, TFIIK contains Ccl1p, Tfb3p and Kin2p.
PMID:19818408
http://purl.org/obo/owl/PMID#PMID_19818408
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
translation initiation complex
cellular_component
A ribonucleoprotein complex that contains a ribosome, mRNA, and initiator tRNA; the functional ribosome is at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
translation preinitiation complex
cellular_component
A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA.
GOC:hjd
http://purl.org/obo/owl/GOC#GOC_hjd
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
U4/U6 snRNP
cellular_component
A ribonucleoprotein complex that contains base-paired U4 and U6 small nuclear RNAs.
PMID:14685174
http://purl.org/obo/owl/PMID#PMID_14685174
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
U4atac/U6atac snRNP
cellular_component
A ribonucleoprotein complex that contains base-paired U4atac and U6atac small nuclear RNAs.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:14685174
http://purl.org/obo/owl/PMID#PMID_14685174
penta-snRNP complex
cellular_component
penta-RNP complex
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
A ribonucleoprotein complex formed by the association of the U1, U2, U4/U6 and U5 small nuclear ribonucleoproteins.
PMID:12724403
http://purl.org/obo/owl/PMID#PMID_12724403
PMID:11804584
http://purl.org/obo/owl/PMID#PMID_11804584
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
U2-type prespliceosome
cellular_component
A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation.
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
PMID:17332742
http://purl.org/obo/owl/PMID#PMID_17332742
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GT-AG prespliceosome
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mammalian U2-type spliceosomal complex A
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
major prespliceosome
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
yeast U2-type spliceosomal complex B
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
U2-type precatalytic spliceosome
cellular_component
GT-AG precatalytic spliceosome
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
major precatalytic spliceosome
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
yeast U12-type spliceosomal complex A2-1
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
mammalian U2-type spliceosomal complex B
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mammalian U2-type spliceosomal complex B1
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
PMID:18322460
http://purl.org/obo/owl/PMID#PMID_18322460
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
U2-type catalytic step 1 spliceosome
cellular_component
GT-AG catalytic step 1 spliceosome
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
mammalian U2-type spliceosomal complex B2
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
major catalytic step 1 spliceosome
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mammalian U2-type spliceosomal complex B*
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
U2-type activated spliceosome
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs.
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
PMID:18322460
http://purl.org/obo/owl/PMID#PMID_18322460
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
yeast U2-type spliceosomal complex A1
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
U2-type catalytic step 2 spliceosome
cellular_component
A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
PMID:18322460
http://purl.org/obo/owl/PMID#PMID_18322460
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mammalian U2-type spliceosomal complex C1
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
yeast U2-type spliceosomal complex A2-2
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GT-AG catalytic step 2 spliceosome
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
major catalytic step 2 spliceosome
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mammalian U2-type spliceosomal complex C
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
U2-type post-mRNA release spliceosomal complex
cellular_component
GT-AG post-mRNA release spliceosomal complex
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mammalian U2-type spliceosomal complex I
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
major post-mRNA release spliceosomal complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs.
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
U4atac/U6atac x U5 tri-snRNP complex
cellular_component
A ribonucleoprotein complex formed by the association of the U4atac/U6atac and U5 small nuclear ribonucleoproteins.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:16201866
http://purl.org/obo/owl/PMID#PMID_16201866
U4atac/U6atac.U5 snRNP complex
prespliceosome
cellular_component
mammalian spliceosomal complex A
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
yeast spliceosomal complex B
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. Prespliceosome complexes are not active for splicing, but are instead an early step in the assembly of a spliceosomal complex.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
PMID:17332742
http://purl.org/obo/owl/PMID#PMID_17332742
prespliceosome
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
precatalytic spliceosome
cellular_component
yeast spliceosomal complex A2-1
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs.
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
PMID:18322460
http://purl.org/obo/owl/PMID#PMID_18322460
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
mammalian spliceosomal complex B
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
mammalian spliceosomal complex B1
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
catalytic step 1 spliceosome
cellular_component
activated spliceosome
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
yeast spliceosomal complex A1
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mammalian spliceosomal complex B*
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
A spliceosomal complex that is formed by the displacement of the two snRNPs from the precatalytic spliceosome; three snRNPs including U5 remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:18322460
http://purl.org/obo/owl/PMID#PMID_18322460
mammalian spliceosomal complex B2
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
catalytic step 2 spliceosome
cellular_component
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
PMID:18322460
http://purl.org/obo/owl/PMID#PMID_18322460
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
mammalian spliceosomal complex C
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
yeast spliceosomal complex A2-2
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
mammalian spliceosomal complex C1
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
post-mRNA release spliceosomal complex
cellular_component
A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, including U5.
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mammalian spliceosomal complex I
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
U12-type prespliceosome
cellular_component
yeast U12-type spliceosomal complex B
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
minor prespliceosome
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
AT-AC prespliceosome
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
mammalian U12-type spliceosomal complex A
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
A spliceosomal complex that is formed by the cooperative binding of the heterodimeric U11/U12 snRNP to the 5' splice site and the branch point sequence. The U12-type prespliceosome includes many proteins in addition to those found in the U11/U12 heterodimeric snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:10197985
http://purl.org/obo/owl/PMID#PMID_10197985
PMID:16201866
http://purl.org/obo/owl/PMID#PMID_16201866
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
U12-type precatalytic spliceosome
cellular_component
mammalian U12-type spliceosomal complex B1
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
AT-AC precatalytic spliceosome
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
minor precatalytic spliceosome
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
yeast U12-type spliceosomal complex A2-1
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
mammalian U12-type spliceosomal complex B
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
A spliceosomal complex that is formed by the recruitment of the preassembled U4atac/U6atac.U5 tri-snRNP to the U12-type prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U11, U12 and U4atac/U6atac.U5 snRNPs.
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
PMID:16201866
http://purl.org/obo/owl/PMID#PMID_16201866
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
U12-type catalytic step 1 spliceosome
cellular_component
mammalian U12-type spliceosomal complex B2
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
A spliceosomal complex that is formed by the displacement of the U11 and U4atac snRNPs from the precatalytic spliceosome; the U12, U5 and U6atac snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U12, and U5 and U6atac snRNPs.
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
PMID:16201866
http://purl.org/obo/owl/PMID#PMID_16201866
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
mammalian U12-type spliceosomal complex B*
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
minor catalytic step 1 spliceosome
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
U12-type activated spliceosome
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
yeast U12-type spliceosomal complex A1
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
AT-AC catalytic step 1 spliceosome
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
U12-type catalytic step 2 spliceosome
cellular_component
minor catalytic step 2 spliceosome
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A spliceosomal complex that contains the U12, U5 and U6atac snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U12, U5 and U6atac snRNPs.
PMID:16201866
http://purl.org/obo/owl/PMID#PMID_16201866
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
yeast U12-type spliceosomal complex A2-2
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
AT-AC catalytic step 2 spliceosome
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mammalian U12-type spliceosomal complex C1
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
mammalian U12-type spliceosomal complex C
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
PMID:19239890
http://purl.org/obo/owl/PMID#PMID_19239890
U12-type post-mRNA release spliceosomal complex
cellular_component
AT-AC post-mRNA release spliceosomal complex
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mammalian U12-type spliceosomal complex I
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U12, U5 and U6atac snRNPs.
GOC:ab
http://purl.org/obo/owl/GOC#GOC_ab
PMID:16201866
http://purl.org/obo/owl/PMID#PMID_16201866
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
minor post-mRNA release spliceosomal complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
post-spliceosomal complex
cellular_component
mammalian spliceosomal complex C2
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
yeast spliceosomal complex A2-3
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5.
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
U2-type post-spliceosomal complex
cellular_component
GT-AG post-spliceosomal complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
major post-spliceosomal complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
yeast U2-type spliceosomal complex A2-3
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
mammalian U2-type spliceosomal complex C2
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5.
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
U12-type post-spliceosomal complex
cellular_component
A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
AT-AC post-spliceosomal complex
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
mammalian U12-type spliceosomal complex C2
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
minor post-spliceosomal complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
yeast U12-type spliceosomal complex A2-3
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ISBN:0879695897
http://purl.org/obo/owl/ISBN#ISBN_0879695897
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
trans spliceosomal complex
cellular_component
A spliceosomal complex that forms during the addition of a specific spliced leader (SL) sequence to the 5'-end of a messenger RNA primary transcript, a process which occurs in a number of eukaryotic organisms, including trypanosomatid protozoans, euglenoids, nematodes, trematodes, and chordates.
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
SL snRNP
cellular_component
A ribonucleoprotein complex that contains spliced leader (SL) RNA.
GOC:krc
http://purl.org/obo/owl/GOC#GOC_krc
ISBN:0879697393
http://purl.org/obo/owl/ISBN#ISBN_0879697393
alpha9-beta1 integrin-ADAM1 complex
cellular_component
ITGA9-ITGB1-ADAM1 complex
CORUM:2964
http://purl.org/obo/owl/CORUM#CORUM_2964
A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM1.
PMID:11882657
http://purl.org/obo/owl/PMID#PMID_11882657
alpha9-beta1 integrin-ADAM2 complex
cellular_component
ITGA9-ITGB1-ADAM2 complex
CORUM:2441
http://purl.org/obo/owl/CORUM#CORUM_2441
A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM2.
PMID:11882657
http://purl.org/obo/owl/PMID#PMID_11882657
alpha9-beta1 integrin-ADAM3 complex
cellular_component
ITGA9-ITGB1-ADAM3 complex
CORUM:2965
http://purl.org/obo/owl/CORUM#CORUM_2965
A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM3.
PMID:11882657
http://purl.org/obo/owl/PMID#PMID_11882657
alpha9-beta1 integrin-ADAM9 complex
cellular_component
ITGA9-ITGB1-ADAM9 complex
CORUM:2440
http://purl.org/obo/owl/CORUM#CORUM_2440
A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM9.
PMID:11882657
http://purl.org/obo/owl/PMID#PMID_11882657
alpha9-beta1 integrin-ADAM15 complex
cellular_component
ITGA9-ITGB1-ADAM15 complex
CORUM:2445
http://purl.org/obo/owl/CORUM#CORUM_2445
A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM15.
PMID:11882657
http://purl.org/obo/owl/PMID#PMID_11882657
alphav-beta3 integrin-ADAM15 complex
cellular_component
ITGAV-ITGB3-ADAM15 complex
CORUM:2359
http://purl.org/obo/owl/CORUM#CORUM_2359
A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM15.
PMID:10944520
http://purl.org/obo/owl/PMID#PMID_10944520
PMID:11882657
http://purl.org/obo/owl/PMID#PMID_11882657
alpha3-beta1 integrin-CD151 complex
cellular_component
ITGA3-ITGB1-CD151 complex
CORUM:2400
http://purl.org/obo/owl/CORUM#CORUM_2400
A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD151.
PMID:10811835
http://purl.org/obo/owl/PMID#PMID_10811835
PMID:11884516
http://purl.org/obo/owl/PMID#PMID_11884516
alpha6-beta1 integrin-CD151 complex
cellular_component
A protein complex that consists of an alpha6-beta1 integrin complex bound to the tetraspanin CD151.
PMID:11884516
http://purl.org/obo/owl/PMID#PMID_11884516
ITGA6-ITGB1-CD151 complex
CORUM:2411
http://purl.org/obo/owl/CORUM#CORUM_2411
alpha7-beta1 integrin-CD151 complex
cellular_component
A protein complex that consists of an alpha7-beta1 integrin complex bound to the tetraspanin CD151.
PMID:11884516
http://purl.org/obo/owl/PMID#PMID_11884516
ITGA7-ITGB1-CD151 complex
CORUM:2395
http://purl.org/obo/owl/CORUM#CORUM_2395
alpha6-beta4 integrin-CD151 complex
cellular_component
ITGA6-ITGB4-CD151 complex
CORUM:2320
http://purl.org/obo/owl/CORUM#CORUM_2320
A protein complex that consists of an alpha6-beta4 integrin complex bound to the tetraspanin CD151.
PMID:10811835
http://purl.org/obo/owl/PMID#PMID_10811835
alphav-beta3 integrin-vitronectin complex
cellular_component
ITGAV-ITGB3-VTN complex
CORUM:2826
http://purl.org/obo/owl/CORUM#CORUM_2826
A protein complex that consists of an alphav-beta3 integrin complex bound to vitronectin.
PMID:10835423
http://purl.org/obo/owl/PMID#PMID_10835423
alphaE-beta7 integrin-E-cadherin complex
cellular_component
ITGAE-ITGB7-CDH1 complex
CORUM:1834
http://purl.org/obo/owl/CORUM#CORUM_1834
A protein complex that consists of an alphaE-beta7 integrin complex bound to E-cadherin.
PMID:10837471
http://purl.org/obo/owl/PMID#PMID_10837471
alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
cellular_component
ITGA9-ITGB1-VCAM1 complex
CORUM:2442
http://purl.org/obo/owl/CORUM#CORUM_2442
A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular cell adhesion molecule-1.
PMID:10209034
http://purl.org/obo/owl/PMID#PMID_10209034
alphav-beta3 integrin-ADAM23 complex
cellular_component
A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM23.
PMID:10749942
http://purl.org/obo/owl/PMID#PMID_10749942
ITGAV-ITGB3-ADAM23 complex
CORUM:2364
http://purl.org/obo/owl/CORUM#CORUM_2364
alpha9-beta1 integrin-ADAM12 complex
cellular_component
ITGA9-ITGB1-ADAM12 complex
CORUM:2447
http://purl.org/obo/owl/CORUM#CORUM_2447
A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM12.
PMID:10944520
http://purl.org/obo/owl/PMID#PMID_10944520
alpha4-beta1 integrin-thrombospondin-1 complex
cellular_component
A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-1.
PMID:11980922
http://purl.org/obo/owl/PMID#PMID_11980922
ITGA4-ITGB1-THBS1 complex
CORUM:2426
http://purl.org/obo/owl/CORUM#CORUM_2426
alpha4-beta1 integrin-thrombospondin-2 complex
cellular_component
ITGA4-ITGB1-THBS2 complex
CORUM:2428
http://purl.org/obo/owl/CORUM#CORUM_2428
A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-2.
PMID:11980922
http://purl.org/obo/owl/PMID#PMID_11980922
CUGBP1-eIF2 complex
cellular_component
A protein complex that contains the eukaryotic translation initiation factor 2 complex (EIF2), CUG binding protein 1, and several endoplasmic reticulum proteins; the complex is involved in the regulation of translation.
PMID:16931514
http://purl.org/obo/owl/PMID#PMID_16931514
fibronectin-tissue transglutaminase complex
cellular_component
FN-TGM2 complex
CORUM:2375
http://purl.org/obo/owl/CORUM#CORUM_2375
A protein complex that consists of fibronectin bound to tissue transglutaminase, and is involved in cell adhesion.
PMID:10684262
http://purl.org/obo/owl/PMID#PMID_10684262
alpha2-beta1 integrin-chondroadherin complex
cellular_component
ITGA2-ITGB1-CHAD complex
CORUM:2430
http://purl.org/obo/owl/CORUM#CORUM_2430
A protein complex that consists of an alpha2-beta1 integrin complex bound to the cartilage matrix protein chondroadherin.
PMID:9281592
http://purl.org/obo/owl/PMID#PMID_9281592
alpha3-beta1 integrin-basigin complex
cellular_component
A protein complex that consists of an alpha3-beta1 integrin complex bound to the cell surface protein basigin.
PMID:9360995
http://purl.org/obo/owl/PMID#PMID_9360995
ITGA3-ITGB1-BSG complex
CORUM:2398
http://purl.org/obo/owl/CORUM#CORUM_2398
alpha3-beta1 integrin-CD63 complex
cellular_component
A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD63.
PMID:7629079
http://purl.org/obo/owl/PMID#PMID_7629079
ITGA3-ITGB1-CD63 complex
CORUM:2399
http://purl.org/obo/owl/CORUM#CORUM_2399
alpha9-beta1 integrin-tenascin complex
cellular_component
A protein complex that consists of an alpha9-beta1 integrin complex bound to the extracellular matrix protein tenascin.
PMID:9565552
http://purl.org/obo/owl/PMID#PMID_9565552
ITGA9-ITGB1-TNC complex
CORUM:2443
http://purl.org/obo/owl/CORUM#CORUM_2443
alphaV-beta3 integrin-CD47-FCER2 complex
cellular_component
ITGAV-ITGB3-CD447-FCER2 complex
CORUM:2355
http://purl.org/obo/owl/CORUM#CORUM_2355
A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface protein CD47 and the low-affinity immunoglobulin epsilon Fc receptor (FCER2).
PMID:10037797
http://purl.org/obo/owl/PMID#PMID_10037797
alpha2-beta1 integrin-CD47 complex
cellular_component
ITGA2-ITGB1-CD47 complex
CORUM:2429
http://purl.org/obo/owl/CORUM#CORUM_2429
A protein complex that consists of an alpha2-beta1 integrin complex bound to the cell surface protein CD47.
PMID:10397731
http://purl.org/obo/owl/PMID#PMID_10397731
alphaIIb-beta3 integrin-CD9 complex
cellular_component
ITGA2b-ITGB3-CD9 complex
CORUM:2370
http://purl.org/obo/owl/CORUM#CORUM_2370
A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface protein CD9.
PMID:10429193
http://purl.org/obo/owl/PMID#PMID_10429193
alphaIIb-beta3 integrin-CD9-CD47-platelet glycoprotein Ib complex
cellular_component
A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface proteins CD9 and CD47, and the heterodimeric platelet glycoprotein Ib.
PMID:10429193
http://purl.org/obo/owl/PMID#PMID_10429193
ITGA2b-ITGB3-CD9-GP1b-CD47 complex
CORUM:2872
http://purl.org/obo/owl/CORUM#CORUM_2872
alpha11-beta1 integrin-collagen type I complex
cellular_component
ITGA11-ITGB1-COL1A1 complex
CORUM:3059
http://purl.org/obo/owl/CORUM#CORUM_3059
A protein complex that consists of an alpha11-beta1 integrin complex bound to a type I collagen.
PMID:10464311
http://purl.org/obo/owl/PMID#PMID_10464311
alpha5-beta1 integrin-tissue transglutaminase complex
cellular_component
A protein complex that consists of an alpha5-beta1 integrin complex bound to tissue transglutaminase.
PMID:10684262
http://purl.org/obo/owl/PMID#PMID_10684262
ITGA5-ITGB1-TGM2 complex
CORUM:2433
http://purl.org/obo/owl/CORUM#CORUM_2433
alphaV-beta3 integrin-tissue transglutaminase complex
cellular_component
ITGAV-ITGB3-TGM2 complex
CORUM:3095
http://purl.org/obo/owl/CORUM#CORUM_3095
A protein complex that consists of an alphaV-beta3 integrin complex bound to tissue transglutaminase.
PMID:10684262
http://purl.org/obo/owl/PMID#PMID_10684262
alphaIIb-beta3 integrin-fibronectin-tissue transglutaminase complex
cellular_component
A protein complex that consists of an alphaIIb-beta3 integrin complex bound to fibronectin and tissue transglutaminase.
PMID:10684262
http://purl.org/obo/owl/PMID#PMID_10684262
ITGA2b-ITGB3-FN1-TGM2 complex
CORUM:2376
http://purl.org/obo/owl/CORUM#CORUM_2376
alpha1-beta1 integrin-tissue transglutaminase complex
cellular_component
ITGA1-ITGB1-TGM2 complex
CORUM:2894
http://purl.org/obo/owl/CORUM#CORUM_2894
A protein complex that consists of an alpha1-beta1 integrin complex bound to tissue transglutaminase.
PMID:10684262
http://purl.org/obo/owl/PMID#PMID_10684262
alpha3-beta1 integrin-tissue transglutaminase complex
cellular_component
A protein complex that consists of an alpha3-beta1 integrin complex bound to tissue transglutaminase.
PMID:10684262
http://purl.org/obo/owl/PMID#PMID_10684262
ITGA3-ITGB1-TGM2 complex
CORUM:2402
http://purl.org/obo/owl/CORUM#CORUM_2402
alpha5-beta1 integrin-fibronectin-tissue transglutaminase complex
cellular_component
ITGA5-ITGB1-FN1-TGM2 complex
CORUM:2383
http://purl.org/obo/owl/CORUM#CORUM_2383
A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and tissue transglutaminase.
PMID:10684262
http://purl.org/obo/owl/PMID#PMID_10684262
alpha6-beta4 integrin-CD9 complex
cellular_component
ITGA6-ITGB4-CD9 complex
CORUM:2770
http://purl.org/obo/owl/CORUM#CORUM_2770
A protein complex that consists of an alpha6-beta4 integrin complex bound to the cell surface protein CD9.
PMID:10711425
http://purl.org/obo/owl/PMID#PMID_10711425
alpha3-beta1 integrin-thrombospondin complex
cellular_component
A protein complex that consists of an alpha3-beta1 integrin complex bound to thrombospondin.
PMID:11358957
http://purl.org/obo/owl/PMID#PMID_11358957
ITGA3-ITGB1-THBS1 complex
CORUM:2401
http://purl.org/obo/owl/CORUM#CORUM_2401
alphaV-beta3 integrin-gelsolin complex
cellular_component
ITGAV-ITGB3-Gsn complex
CORUM:2360
http://purl.org/obo/owl/CORUM#CORUM_2360
A protein complex that consists of an alphaV-beta3 integrin complex bound to gelsolin.
PMID:11577104
http://purl.org/obo/owl/PMID#PMID_11577104
alphaV-beta3 integrin-paxillin-Pyk2 complex
cellular_component
ITGAV-ITGB3-PXN-PTK2b complex
CORUM:2363
http://purl.org/obo/owl/CORUM#CORUM_2363
A protein complex that consists of an alphaV-beta3 integrin complex bound to paxillin and the FAK-related kinase Pyk2.
PMID:11683411
http://purl.org/obo/owl/PMID#PMID_11683411
alpha6-beta4 integrin-Fyn complex
cellular_component
A protein complex that consists of an alpha6-beta4 integrin complex bound to the Src family tyrosine kinase Fyn.
PMID:11684709
http://purl.org/obo/owl/PMID#PMID_11684709
ITGA6-ITGB4-FYN complex
CORUM:2321
http://purl.org/obo/owl/CORUM#CORUM_2321
alphaV-beta6 integrin-TGFbeta-3 complex
cellular_component
A protein complex that consists of an alphaV-beta6 integrin complex bound to transforming growth factor beta-3 (TGFbeta-3).
PMID:11821050
http://purl.org/obo/owl/PMID#PMID_11821050
ITGAV-ITGB6-TFGB3 complex
CORUM:2353
http://purl.org/obo/owl/CORUM#CORUM_2353
alphaV-beta8 integrin-MMP14-TGFbeta-1 complex
cellular_component
A protein complex that consists of an alphaV-beta8 integrin complex bound to matrix metalloproteinase 14 and transforming growth factor beta-1 (TGFbeta-1).
PMID:11970960
http://purl.org/obo/owl/PMID#PMID_11970960
ITGAV-ITGB8-MMP14-TGFB1 complex
CORUM:2342
http://purl.org/obo/owl/CORUM#CORUM_2342
alpha4-beta1 integrin-JAM2 complex
cellular_component
ITGA4-ITGB1-JAM2 complex
CORUM:2422
http://purl.org/obo/owl/CORUM#CORUM_2422
A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell adhesion molecule JAM2.
PMID:12070135
http://purl.org/obo/owl/PMID#PMID_12070135
alpha4-beta1 integrin-paxillin complex
cellular_component
ITGA4-ITGB1-PXN complex
CORUM:2425
http://purl.org/obo/owl/CORUM#CORUM_2425
A protein complex that consists of an alpha4-beta1 integrin complex bound to paxillin.
PMID:12221126
http://purl.org/obo/owl/PMID#PMID_12221126
alpha4-beta4 integrin-EMILIN-1 complex
cellular_component
ITGA4-ITGB4-EMILIN1 complex
CORUM:2417
http://purl.org/obo/owl/CORUM#CORUM_2417
A protein complex that consists of an alpha4-beta4 integrin complex bound to EMILIN-1 (ElastinMicrofibril Interface Located ProteIN).
PMID:12456677
http://purl.org/obo/owl/PMID#PMID_12456677
alphaIIb-beta3 integrin-ICAM-4 complex
cellular_component
A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell adhesion molecule ICAM-4.
PMID:12477717
http://purl.org/obo/owl/PMID#PMID_12477717
ITGAIIb-ITGB3-ICAM4 complex
CORUM:3115
http://purl.org/obo/owl/CORUM#CORUM_3115
alphaV-beta3 integrin-tumstatin complex
cellular_component
ITGAV-ITGB3-COL4A3 complex
CORUM:2365
http://purl.org/obo/owl/CORUM#CORUM_2365
A protein complex that consists of an alphaV-beta3 integrin complex bound to tumstatin, the NC1 domain of the alpha3 chain of type IV collagen.
PMID:12682293
http://purl.org/obo/owl/PMID#PMID_12682293
alpha5-beta1 integrin-endostatin complex
cellular_component
ITGA5-ITGB1-CAL4A3 complex
CORUM:2853
http://purl.org/obo/owl/CORUM#CORUM_2853
A protein complex that consists of an alpha5-beta1 integrin complex bound to endostatin, the NC1 domain of the alpha1 chain of type XVIII collagen.
PMID:12682293
http://purl.org/obo/owl/PMID#PMID_12682293
alpha6-beta1 integrin-CYR61 complex
cellular_component
ITGA6-ITGB1-CYR61 complex
CORUM:2437
http://purl.org/obo/owl/CORUM#CORUM_2437
A protein complex that consists of an alpha6-beta1 integrin complex bound to CYR61, a cysteine-rich protein involved in angiogenesis.
PMID:12826661
http://purl.org/obo/owl/PMID#PMID_12826661
alpha5-beta1 integrin-fibronectin-NOV complex
cellular_component
ITGA5-ITGB1-FN-1-NOV complex
CORUM:2850
http://purl.org/obo/owl/CORUM#CORUM_2850
A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and the extracellular matrix protein NOV.
PMID:12902636
http://purl.org/obo/owl/PMID#PMID_12902636
alphaV-beta3 integrin-NOV complex
cellular_component
A protein complex that consists of an alphaV-beta3 integrin complex bound to the extracellular matrix protein NOV.
PMID:12902636
http://purl.org/obo/owl/PMID#PMID_12902636
ITGAV-ITGB3-FN-1-NOV complex
CORUM:2849
http://purl.org/obo/owl/CORUM#CORUM_2849
alpha7-beta1 integrin-nicotinamide riboside kinase complex
cellular_component
ITGA7-ITGB1-ITGB1BP3 complex
CORUM:2397
http://purl.org/obo/owl/CORUM#CORUM_2397
A protein complex that consists of an alpha7-beta1 integrin complex bound to nicotinamide riboside kinase 2 (also known as muscle integrin binding protein, MIBP).
PMID:12941630
http://purl.org/obo/owl/PMID#PMID_12941630
alpha4-beta1 integrin-CD47 complex
cellular_component
A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell surface antigen CD47.
PMID:15292185
http://purl.org/obo/owl/PMID#PMID_15292185
ITGA4-ITGB1-CB47 complex
CORUM:2423
http://purl.org/obo/owl/CORUM#CORUM_2423
alpha9-beta1 integrin-VEGF-D complex
cellular_component
ITGA9-ITGB1-FIGF complex
CORUM:2446
http://purl.org/obo/owl/CORUM#CORUM_2446
A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor D.
PMID:15590642
http://purl.org/obo/owl/PMID#PMID_15590642
alpha9-beta1 integrin-VEGF-A complex
cellular_component
A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor A.
PMID:17363377
http://purl.org/obo/owl/PMID#PMID_17363377
ITGA9-ITGB1-VEGFA complex
CORUM:2972
http://purl.org/obo/owl/CORUM#CORUM_2972
alpha9-beta1 integrin-VEGF-C complex
cellular_component
ITGA9-ITGB1-VEGFC complex
CORUM:2971
http://purl.org/obo/owl/CORUM#CORUM_2971
A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor C.
PMID:15590642
http://purl.org/obo/owl/PMID#PMID_15590642
alpha1-beta1 integrin-tyrosine-protein phosphatase non-receptor type 2 complex
cellular_component
ITGA1-ITGB1-PTPN2 complex
CORUM:2435
http://purl.org/obo/owl/CORUM#CORUM_2435
A protein complex that consists of an alpha1-beta1 integrin complex bound to tyrosine-protein phosphatase non-receptor type 2.
PMID:15592458
http://purl.org/obo/owl/PMID#PMID_15592458
alphaV-beta3 integrin-EGFR complex
cellular_component
ITGAV-ITGB3-EGFR complex
CORUM:2369
http://purl.org/obo/owl/CORUM#CORUM_2369
A protein complex that consists of an alphaV-beta3 integrin complex bound to epidermal growth factor receptor.
PMID:15834425
http://purl.org/obo/owl/PMID#PMID_15834425
alphaV-beta6 integrin-osteopontin complex
cellular_component
A protein complex that consists of an alphaV-beta6 integrin complex bound to osteopontin.
PMID:16005200
http://purl.org/obo/owl/PMID#PMID_16005200
ITGAV-ITGB6-SPP1 complex
CORUM:2352
http://purl.org/obo/owl/CORUM#CORUM_2352
alpha9-beta1 integrin-osteopontin complex
cellular_component
A protein complex that consists of an alpha9-beta1 integrin complex bound to osteopontin.
PMID:16005200
http://purl.org/obo/owl/PMID#PMID_16005200
ITGA9-ITGB1-SPP1 complex
CORUM:3111
http://purl.org/obo/owl/CORUM#CORUM_3111
alpha5-beta1 integrin-osteopontin complex
cellular_component
ITGA5-ITGB1-SPP1 complex
CORUM:3112
http://purl.org/obo/owl/CORUM#CORUM_3112
A protein complex that consists of an alpha5-beta1 integrin complex bound to osteopontin.
PMID:16005200
http://purl.org/obo/owl/PMID#PMID_16005200
alphaV-beta3 integrin-LPP3 complex
cellular_component
A protein complex that consists of an alphaV-beta3 integrin complex bound to lipid phosphate phosphohydrolase-3.
PMID:16099422
http://purl.org/obo/owl/PMID#PMID_16099422
ITGAV-ITGB3-PPAP2B complex
CORUM:2366
http://purl.org/obo/owl/CORUM#CORUM_2366
alpha5-beta1 integrin-LPP3 complex
cellular_component
A protein complex that consists of an alpha5-beta1 integrin complex bound to lipid phosphate phosphohydrolase-3.
PMID:16099422
http://purl.org/obo/owl/PMID#PMID_16099422
ITGA5-ITGB1-PPAP2B complex
CORUM:2386
http://purl.org/obo/owl/CORUM#CORUM_2386
alphaV-beta3 integrin-laminin alpha-4 complex
cellular_component
ITGAV-ITGB3-LAMA4 complex
CORUM:2374
http://purl.org/obo/owl/CORUM#CORUM_2374
A protein complex that consists of an alphaV-beta3 integrin complex bound to laminin alpha-4.
PMID:16824487
http://purl.org/obo/owl/PMID#PMID_16824487
alphaX-beta2 integrin-ICAM-4 complex
cellular_component
A protein complex that consists of an alphaX-beta2 integrin complex bound to intercellular adhesion molecule 4.
PMID:16985175
http://purl.org/obo/owl/PMID#PMID_16985175
ITGAX-ITGB2-ICAM4 complex
CORUM:3114
http://purl.org/obo/owl/CORUM#CORUM_3114
alpha9-beta1 integrin-ADAM8 complex
cellular_component
A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM8.
PMID:16995821
http://purl.org/obo/owl/PMID#PMID_16995821
ITGA9-ITGB1-ADAM8 complex
CORUM:2989
http://purl.org/obo/owl/CORUM#CORUM_2989
alpha9-beta1 integrin-thrombospondin-1 complex
cellular_component
A protein complex that consists of an alpha9-beta1 integrin complex bound to thrombospondin-1.
PMID:17413041
http://purl.org/obo/owl/PMID#PMID_17413041
ITGA9-ITGB1-THBS1 complex
CORUM:2967
http://purl.org/obo/owl/CORUM#CORUM_2967
alpha7-beta1 integrin-focal adhesion kinase complex
cellular_component
ITGA7-ITGB1-PTK2 complex
CORUM:3106
http://purl.org/obo/owl/CORUM#CORUM_3106
A protein complex that consists of an alpha7-beta1 integrin complex bound to focal adhesion kinase.
PMID:17598176
http://purl.org/obo/owl/PMID#PMID_17598176
alpha7-beta1 integrin-laminin alpha-2 complex
cellular_component
ITGA7-ITGB1-LAMA2 complex
CORUM:3105
http://purl.org/obo/owl/CORUM#CORUM_3105
A protein complex that consists of an alpha7-beta1 integrin complex bound to laminin alpha-2.
PMID:17598176
http://purl.org/obo/owl/PMID#PMID_17598176
alphaV-beta3 integrin-CD98 complex
cellular_component
A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface antigen CD98.
PMID:18032696
http://purl.org/obo/owl/PMID#PMID_18032696
ITGAV-ITGB3-SLC3A2 complex
CORUM:3103
http://purl.org/obo/owl/CORUM#CORUM_3103
alpha5-beta5-fibronectin-SFRP2 complex
cellular_component
A protein complex that consists of an alpha5-beta5 integrin complex bound to fibronectin and secreted frizzled-related protein 2.
PMID:14709558
http://purl.org/obo/owl/PMID#PMID_14709558
ITGA5-ITGB5-FN-1-SFRP2 complex
CORUM:2388
http://purl.org/obo/owl/CORUM#CORUM_2388
SMAD protein complex
cellular_component
SMAD complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A protein complex that consists of SMAD proteins; may be homomeric or heteromeric.
PMID:9670020
http://purl.org/obo/owl/PMID#PMID_9670020
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
SMAD2 protein complex
cellular_component
A protein complex that consists of a SMAD2 homotrimer.
PMID:9670020
http://purl.org/obo/owl/PMID#PMID_9670020
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
SMAD2 homotrimer complex
CORUM:2999
http://purl.org/obo/owl/CORUM#CORUM_2999
SMAD3 protein complex
cellular_component
SMAD3 homotrimer complex
CORUM:3003
http://purl.org/obo/owl/CORUM#CORUM_3003
A protein complex that consists of a SMAD3 homotrimer.
PMID:9670020
http://purl.org/obo/owl/PMID#PMID_9670020
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
SMAD2-SMAD3 protein complex
cellular_component
A heteromeric SMAD protein complex that contains SMAD2 and SMAD3.
PMID:9670020
http://purl.org/obo/owl/PMID#PMID_9670020
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
SMAD2-SMAD3 complex
CORUM:3000
http://purl.org/obo/owl/CORUM#CORUM_3000
SMAD2-SMAD4 protein complex
cellular_component
A heteromeric SMAD protein complex that contains SMAD2 and SMAD4.
PMID:9670020
http://purl.org/obo/owl/PMID#PMID_9670020
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
SMAD2-SMAD4 heteromer complex
CORUM:3001
http://purl.org/obo/owl/CORUM#CORUM_3001
SMAD3-SMAD4 protein complex
cellular_component
SMAD3-SMAD4 complex
CORUM:3002
http://purl.org/obo/owl/CORUM#CORUM_3002
A heteromeric SMAD protein complex that contains SMAD3 and SMAD4.
PMID:9670020
http://purl.org/obo/owl/PMID#PMID_9670020
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
TEAD-2 multiprotein complex
cellular_component
A protein complex that consists of the DNA binding protein TEAD-2 bound to 12 other polypeptides including the transcriptional coactivator YAP, the multi-PDZ domain protein MPDZ (also called MUPP1), a 14-3-3 domain protein, and others.
CORUM:2870
http://purl.org/obo/owl/CORUM#CORUM_2870
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:11358867
http://purl.org/obo/owl/PMID#PMID_11358867
TEAD-1-YAP complex
cellular_component
A transcription factor complex that is composed of the DNA biding protein TEAD-1 and the transcriptional coactivator YAP.
PMID:11358867
http://purl.org/obo/owl/PMID#PMID_11358867
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
TEAD-2-YAP complex
cellular_component
A transcription factor complex that is composed of the DNA biding protein TEAD-2 and the transcriptional coactivator YAP.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:11358867
http://purl.org/obo/owl/PMID#PMID_11358867
TEAD-3-YAP complex
cellular_component
A transcription factor complex that is composed of the DNA biding protein TEAD-3 and the transcriptional coactivator YAP.
PMID:11358867
http://purl.org/obo/owl/PMID#PMID_11358867
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
TEAD-4-YAP complex
cellular_component
A transcription factor complex that is composed of the DNA biding protein TEAD-4 and the transcriptional coactivator YAP.
PMID:11358867
http://purl.org/obo/owl/PMID#PMID_11358867
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
G-protein alpha(q)-synembrin complex
cellular_component
A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(q) subunit of a heterotrimeric G protein.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:12509430
http://purl.org/obo/owl/PMID#PMID_12509430
Ric-8A G(q) alpha subunit complex
CORUM:175
http://purl.org/obo/owl/CORUM#CORUM_175
G-protein alpha(o)-synembrin complex
cellular_component
A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(o) subunit of a heterotrimeric G protein.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:12509430
http://purl.org/obo/owl/PMID#PMID_12509430
Ric-8A G(o) alpha-2 subunit complex
CORUM:174
http://purl.org/obo/owl/CORUM#CORUM_174
Ric-8A G(o) alpha-1 subunit complex
CORUM:172
http://purl.org/obo/owl/CORUM#CORUM_172
G-protein alpha(i)1-synembrin complex
cellular_component
Ric-8A G(i) alpha-1 subunit complex
CORUM:170
http://purl.org/obo/owl/CORUM#CORUM_170
Ric-8A G(i) alpha-2 subunit complex
CORUM:171
http://purl.org/obo/owl/CORUM#CORUM_171
A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(i)1 subunit of a heterotrimeric G protein.
PMID:12509430
http://purl.org/obo/owl/PMID#PMID_12509430
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
G-protein alpha(13)-synembrin complex
cellular_component
Ric-8A G alpha 13 subunit complex
CORUM:176
http://purl.org/obo/owl/CORUM#CORUM_176
A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(13) subunit of a heterotrimeric G protein.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:12509430
http://purl.org/obo/owl/PMID#PMID_12509430
NF-kappaB complex
cellular_component
A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression.
ISBN:0849327946
http://purl.org/obo/owl/ISBN#ISBN_0849327946
CMG complex
cellular_component
A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication.
PMID:19228417
http://purl.org/obo/owl/PMID#PMID_19228417
unwindosome
PMID:19228417
http://purl.org/obo/owl/PMID#PMID_19228417
MAML2-RBP-Jkappa-ICN1 complex
cellular_component
MAML2-RBP-Jkappa-Notch1 complex
CORUM:1949
http://purl.org/obo/owl/CORUM#CORUM_1949
A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
PMID:12370315
http://purl.org/obo/owl/PMID#PMID_12370315
MAML2-RBP-Jkappa-ICN2 complex
cellular_component
MAML2-RBP-Jkappa-Notch2 complex
CORUM:3217
http://purl.org/obo/owl/CORUM#CORUM_3217
A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
PMID:12370315
http://purl.org/obo/owl/PMID#PMID_12370315
MAML2-RBP-Jkappa-ICN3 complex
cellular_component
A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
PMID:12370315
http://purl.org/obo/owl/PMID#PMID_12370315
MAML2-RBP-Jkappa-Notch3 complex
CORUM:3218
http://purl.org/obo/owl/CORUM#CORUM_3218
MAML2-RBP-Jkappa-ICN4 complex
cellular_component
A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
PMID:12370315
http://purl.org/obo/owl/PMID#PMID_12370315
MAML2-RBP-Jkappa-Notch4 complex
CORUM:3219
http://purl.org/obo/owl/CORUM#CORUM_3219
MAML3-RBP-Jkappa-ICN1 complex
cellular_component
A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
PMID:12370315
http://purl.org/obo/owl/PMID#PMID_12370315
MAML3-RBP-Jkappa-Notch1 complex
CORUM:3220
http://purl.org/obo/owl/CORUM#CORUM_3220
MAML3-RBP-Jkappa-ICN2 complex
cellular_component
A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
PMID:12370315
http://purl.org/obo/owl/PMID#PMID_12370315
MAML3-RBP-Jkappa-Notch2 complex
CORUM:3221
http://purl.org/obo/owl/CORUM#CORUM_3221
MAML3-RBP-Jkappa-ICN3 complex
cellular_component
MAML3-RBP-Jkappa-Notch3 complex
CORUM:3222
http://purl.org/obo/owl/CORUM#CORUM_3222
A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
PMID:12370315
http://purl.org/obo/owl/PMID#PMID_12370315
MAML3-RBP-Jkappa-ICN4 complex
cellular_component
A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
PMID:12370315
http://purl.org/obo/owl/PMID#PMID_12370315
MAML3-RBP-Jkappa-Notch4 complex
CORUM:3223
http://purl.org/obo/owl/CORUM#CORUM_3223
protocadherin-alpha-protocadherin-gamma complex
cellular_component
A protein complex that contains two cell adhesion molecules, a protocadherin-alpha and a protocadherin-gamma, and is involved in the regulation of protein localization to the plasma membrane.
PMID:15347688
http://purl.org/obo/owl/PMID#PMID_15347688
protocadherin-alpha-v4-protocadherin-gamma-a1 complex
cellular_component
Pcdhga1-Pcdha4 complex
CORUM:1014
http://purl.org/obo/owl/CORUM#CORUM_1014
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane.
PMID:15347688
http://purl.org/obo/owl/PMID#PMID_15347688
protocadherin-alpha-v4-protocadherin-gamma-a3 complex
cellular_component
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane.
PMID:15347688
http://purl.org/obo/owl/PMID#PMID_15347688
Pcdhga1-Pcdhga3 complex
CORUM:1016
http://purl.org/obo/owl/CORUM#CORUM_1016
protocadherin-alpha-v4-protocadherin-gamma-b2 complex
cellular_component
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane.
PMID:15347688
http://purl.org/obo/owl/PMID#PMID_15347688
Pcdhga1-Pcdhgb2 complex
CORUM:1015
http://purl.org/obo/owl/CORUM#CORUM_1015
protocadherin-alpha-v4-protocadherin-gamma-b4 complex
cellular_component
Pcdhga1-Pcdhgb4 complex
CORUM:1017
http://purl.org/obo/owl/CORUM#CORUM_1017
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane.
PMID:15347688
http://purl.org/obo/owl/PMID#PMID_15347688
protocadherin-alpha-v7-protocadherin-gamma-a1 complex
cellular_component
Pcdha7-Pcdhga1 complex
CORUM:1021
http://purl.org/obo/owl/CORUM#CORUM_1021
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane.
PMID:15347688
http://purl.org/obo/owl/PMID#PMID_15347688
protocadherin-alpha-v7-protocadherin-gamma-a3 complex
cellular_component
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane.
PMID:15347688
http://purl.org/obo/owl/PMID#PMID_15347688
Pcdha7-Pcdhga3 complex
CORUM:1019
http://purl.org/obo/owl/CORUM#CORUM_1019
protocadherin-alpha-v7-protocadherin-gamma-b2 complex
cellular_component
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane.
PMID:15347688
http://purl.org/obo/owl/PMID#PMID_15347688
Pcdha7-Pcdhgb4 complex
CORUM:1018
http://purl.org/obo/owl/CORUM#CORUM_1018
protocadherin-alpha-v7-protocadherin-gamma-b4 complex
cellular_component
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane.
PMID:15347688
http://purl.org/obo/owl/PMID#PMID_15347688
Pcdha7-Pcdhgb2 complex
CORUM:1020
http://purl.org/obo/owl/CORUM#CORUM_1020
Kv4.2-KChIP1 channel complex
cellular_component
A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.2.
PMID:15356203
http://purl.org/obo/owl/PMID#PMID_15356203
CORUM:606
http://purl.org/obo/owl/CORUM#CORUM_606
Kv4.2-KChIP2 channel complex
cellular_component
A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP2 associated with the channel via interaction with the Kv alpha subunit 4.2.
PMID:15356203
http://purl.org/obo/owl/PMID#PMID_15356203
CORUM:607
http://purl.org/obo/owl/CORUM#CORUM_607
Kv4.2-KChIP3 channel complex
cellular_component
CORUM:608
http://purl.org/obo/owl/CORUM#CORUM_608
A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP3 associated with the channel via interaction with the Kv alpha subunit 4.2.
PMID:15356203
http://purl.org/obo/owl/PMID#PMID_15356203
Kv4.2-KChIP4 channel complex
cellular_component
CORUM:3090
http://purl.org/obo/owl/CORUM#CORUM_3090
A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP4 associated with the channel via interaction with the Kv alpha subunit 4.2.
PMID:15356203
http://purl.org/obo/owl/PMID#PMID_15356203
Kv4.3-KChIP1 channel complex
cellular_component
CORUM:3091
http://purl.org/obo/owl/CORUM#CORUM_3091
A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.3.
PMID:15356203
http://purl.org/obo/owl/PMID#PMID_15356203
Kv4.2-Kv4.3 channel complex
cellular_component
CORUM:609
http://purl.org/obo/owl/CORUM#CORUM_609
A voltage-gated potassium channel complex that contains the Kv alpha subunits 4.2 and 4.3.
PMID:15356203
http://purl.org/obo/owl/PMID#PMID_15356203
Kv4.1-DPP6 channel complex
cellular_component
A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.1.
PMID:15911355
http://purl.org/obo/owl/PMID#PMID_15911355
CORUM:600
http://purl.org/obo/owl/CORUM#CORUM_600
Kv4.1-DPPX channel complex
PMID:15911355
http://purl.org/obo/owl/PMID#PMID_15911355
Kv4.1-DPP10 channel complex
cellular_component
CORUM:601
http://purl.org/obo/owl/CORUM#CORUM_601
A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.1.
PMID:15911355
http://purl.org/obo/owl/PMID#PMID_15911355
Kv4.1-DPPY channel complex
PMID:15911355
http://purl.org/obo/owl/PMID#PMID_15911355
Kv4.2-DPP6 channel complex
cellular_component
A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.2.
PMID:15911355
http://purl.org/obo/owl/PMID#PMID_15911355
PMID:12575952
http://purl.org/obo/owl/PMID#PMID_12575952
CORUM:603
http://purl.org/obo/owl/CORUM#CORUM_603
Kv4.2-DPPX channel complex
PMID:15911355
http://purl.org/obo/owl/PMID#PMID_15911355
Kv4.3-DPP6 channel complex
cellular_component
CORUM:599
http://purl.org/obo/owl/CORUM#CORUM_599
A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.3.
PMID:12575952
http://purl.org/obo/owl/PMID#PMID_12575952
PMID:15911355
http://purl.org/obo/owl/PMID#PMID_15911355
Kv4.3-DPPX channel complex
PMID:15911355
http://purl.org/obo/owl/PMID#PMID_15911355
Kv4.3-DPP10 channel complex
cellular_component
A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.3.
PMID:15911355
http://purl.org/obo/owl/PMID#PMID_15911355
CORUM:598
http://purl.org/obo/owl/CORUM#CORUM_598
Kv4.3-DPPY channel complex
PMID:15911355
http://purl.org/obo/owl/PMID#PMID_15911355
WASH complex
cellular_component
A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53.
GOC:sp
http://purl.org/obo/owl/GOC#GOC_sp
PMID:19922875
http://purl.org/obo/owl/PMID#PMID_19922875
histone pre-mRNA 3'end processing complex
cellular_component
A ribonucleoprotein that binds to specific sites in, and is required for cleavage of, the 3'-end of histone pre-mRNAs. The complex contains the U7 snRNP and additional proteins, including the stem-loop binding protein (SLBP) and the exonuclease 3'hExo/Eri-1.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:19470752
http://purl.org/obo/owl/PMID#PMID_19470752
histone 3'end pre-mRNA complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
subsynaptic reticulum
cellular_component
SSR
PMID:19244343
http://purl.org/obo/owl/PMID#PMID_19244343
An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.
PMID:7946331
http://purl.org/obo/owl/PMID#PMID_7946331
PMID:1460464
http://purl.org/obo/owl/PMID#PMID_1460464
PMID:18171947
http://purl.org/obo/owl/PMID#PMID_18171947
PMID:19244343
http://purl.org/obo/owl/PMID#PMID_19244343
cytoplasmic U snRNP body
cellular_component
U-body
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
U body
PMID:17595295
http://purl.org/obo/owl/PMID#PMID_17595295
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies.
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
PMID:17595295
http://purl.org/obo/owl/PMID#PMID_17595295
translocon complex
cellular_component
GO:0031206
A protein complex that constitutes a specific site of protein translocation across the endoplasmic reticulum, which involves the signal recognition particle receptor. The complex contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins.
PMID:8612571
http://purl.org/obo/owl/PMID#PMID_8612571
PMID:18166647
http://purl.org/obo/owl/PMID#PMID_18166647
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:10611978
http://purl.org/obo/owl/PMID#PMID_10611978
Sec complex-associated translocon complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Ssh1 translocon complex
cellular_component
Ssh1p-Sss1p-Sbh2p complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A translocon complex that contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Ssh1p, Sbh2p, and Sss1p. The Ssh1 translocon complex is involved in the cotranslational pathway of protein transport across the ER membrane, and recognizes proteins bearing strongly hydrophobic signal sequences.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:8612571
http://purl.org/obo/owl/PMID#PMID_8612571
PMID:12134063
http://purl.org/obo/owl/PMID#PMID_12134063
MLL1 complex
cellular_component
A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
GOC:sp
http://purl.org/obo/owl/GOC#GOC_sp
PMID:15960975
http://purl.org/obo/owl/PMID#PMID_15960975
medial cortical node
cellular_component
mid1p medial cortical dot
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
midsome
PMID:19959363
http://purl.org/obo/owl/PMID#PMID_19959363
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
A protein complex that contains the mid1, cdr2, wee1, klp8, and blt1 proteins, and is involved in contractile ring localization. Medial cortical node complexes appear as cortical dots in the middle of the cell during interphase, and function to recruit other ring components in early mitosis.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:19474789
http://purl.org/obo/owl/PMID#PMID_19474789
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:19959363
http://purl.org/obo/owl/PMID#PMID_19959363
invadopodium
cellular_component
A cell projection that emerges from the ECM-facing surface of a cell, is enriched in actin and associated cytoskeletal proteins, and displays localized proteolytic activity toward the substrate.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:19931459
http://purl.org/obo/owl/PMID#PMID_19931459
PMID:16651416
http://purl.org/obo/owl/PMID#PMID_16651416
PMID:19491051
http://purl.org/obo/owl/PMID#PMID_19491051
invadopodium membrane
cellular_component
The portion of the plasma membrane surrounding an invadopodium.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
clathrin complex
cellular_component
clathrin triskelion
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface.
PMID:16493411
http://purl.org/obo/owl/PMID#PMID_16493411
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
integral to cytosolic side of endoplasmic reticulum membrane
cellular_component
integral to cytosolic side of ER membrane
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Penetrating at least one phospholipid bilayer of the endoplasmic reticulum membrane, with the bulk of the gene product located on the side that faces the cytosol.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
integral to ER membrane, cytosolic side
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
phosphopantothenoylcysteine decarboxylase complex
See also the molecular function term 'acetolactate synthase activity ; GO:0003984'.
cellular_component
A protein complex that catalyzes decarboxylation of 4'-phosphopantothenoylcysteine to yield 4'-phosphopantetheine; this is the third step in the biosynthesis of Coenzyme A. The complex is homotrimeric in many eukaryotes, but is a heterotrimer in Saccharomyces.
PMID:19915539
http://purl.org/obo/owl/PMID#PMID_19915539
GOC:jh
http://purl.org/obo/owl/GOC#GOC_jh
Cdc42 GTPase complex
cellular_component
Ras1-Scd1-Scd2-Cdc42-Shk1 complex
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
A protein complex formed by the association of the small GTPase Cdc42 with additional proteins. In Schizosaccharomyces the complex contains the Cdc42, Ras1, Scd1, Scd2, andShk1 proteins, and functions in the Ras1-Scd GTPase signalling pathway.
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:8943016
http://purl.org/obo/owl/PMID#PMID_8943016
PMID:7923372
http://purl.org/obo/owl/PMID#PMID_7923372
PMID:10567532
http://purl.org/obo/owl/PMID#PMID_10567532
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
eukaryotic translation initiation factor 3 complex, eIF3e
cellular_component
eIF3e-containing eukaryotic translation initiation factor 3 complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e.
PMID:15904532
http://purl.org/obo/owl/PMID#PMID_15904532
PMID:19061185
http://purl.org/obo/owl/PMID#PMID_19061185
eukaryotic translation initiation factor 3 complex, eIF3m
cellular_component
An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m.
PMID:19061185
http://purl.org/obo/owl/PMID#PMID_19061185
PMID:15904532
http://purl.org/obo/owl/PMID#PMID_15904532
eIF3m-containing eukaryotic translation initiation factor 3 complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
pi-body
cellular_component
intermitochondrial cement
GOC:sp
http://purl.org/obo/owl/GOC#GOC_sp
A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes.
PMID:20011505
http://purl.org/obo/owl/PMID#PMID_20011505
GOC:sp
http://purl.org/obo/owl/GOC#GOC_sp
piP-body
cellular_component
A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway.
PMID:20011505
http://purl.org/obo/owl/PMID#PMID_20011505
GOC:sp
http://purl.org/obo/owl/GOC#GOC_sp
integral to lumenal side of endoplasmic reticulum membrane
cellular_component
integral to ER membrane, lumenal side
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
integral to lumenal side of ER membrane
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Penetrating at least one phospholipid bilayer of the endoplasmic reticulum membrane, with the bulk of the gene product located on the side that faces the lumen.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
nucleus-vacuole junction
cellular_component
NVJ
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:16806880
http://purl.org/obo/owl/PMID#PMID_16806880
An organelle membrane contact site formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p.
PMID:16709156
http://purl.org/obo/owl/PMID#PMID_16709156
PMID:16806880
http://purl.org/obo/owl/PMID#PMID_16806880
GOC:jp
http://purl.org/obo/owl/GOC#GOC_jp
NV junction
PMID:16709156
http://purl.org/obo/owl/PMID#PMID_16709156
GOC:jp
http://purl.org/obo/owl/GOC#GOC_jp
nucleus-vacuole membrane contact site
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Myo2p-Vac17p-Vac8p transport complex
cellular_component
A protein complex that is involved in transport of vacuoles to a newly formed daughter cell. In yeast, this complex is composed of Myo2p, Vac17p, and Vac8p.
PMID:12594460
http://purl.org/obo/owl/PMID#PMID_12594460
GOC:jp
http://purl.org/obo/owl/GOC#GOC_jp
npBAF complex
cellular_component
A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells.
GOC:ss
http://purl.org/obo/owl/GOC#GOC_ss
PMID:17640523
http://purl.org/obo/owl/PMID#PMID_17640523
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
nBAF complex
cellular_component
A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:ss
http://purl.org/obo/owl/GOC#GOC_ss
PMID:17640523
http://purl.org/obo/owl/PMID#PMID_17640523
integral to external side of plasma membrane
cellular_component
Penetrating at least one phospholipid bilayer of the plasma membrane, with the bulk of the gene product located on the side opposite to the side that faces the cytoplasm.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Nem1-Spo7 phosphatase complex
cellular_component
A protein serine/threonine phosphatase complex that is involved in nuclear envelope organization, and contains proteins known in budding yeast as Nem1p and Spo7p.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:9822591
http://purl.org/obo/owl/PMID#PMID_9822591
cellular birth scar
cellular_component
Crater-like ring of chitinous scar tissue located on the surface of the daughter cell, in budding fungi, at the site of separation from the mother cell. It is formed after the newly emerged daughter cell separates, thereby marking the site of cytokinesis and septation.
PMID:7730409
http://purl.org/obo/owl/PMID#PMID_7730409
PMID:16672383
http://purl.org/obo/owl/PMID#PMID_16672383
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
neuronal ribonucleoprotein granule
cellular_component
A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli.
GOC:go_curators
http://purl.org/obo/owl/GOC#GOC_go_curators
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:19015237
http://purl.org/obo/owl/PMID#PMID_19015237
PMID:20368989
http://purl.org/obo/owl/PMID#PMID_20368989
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
neuronal RNA granule
neuronal RNP granule
sphere organelle
cellular_component
A nuclear body that is found in the germinal vesicles of amphibian oocytes, and consist of three major parts: a remarkably spherical body about 5-10 pm in diameter, smaller spherical or nearly spherical granules on the surface, and inclusions of various sizes that strongly resemble the surface granules. The parts of the sphere organelle have distinct compositions, including splicing snRNAs and proteins.
PMID:7758244
http://purl.org/obo/owl/PMID#PMID_7758244
PMID:8349728
http://purl.org/obo/owl/PMID#PMID_8349728
integral to fungal-type vacuolar membrane
cellular_component
Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the fungal-type vacuolar membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
intrinsic to fungal-type vacuolar membrane
cellular_component
Located in the fungal-type vacuolar membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
catenin-TCF7L2 complex
cellular_component
catenin-TCF4 complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A protein complex that contains a catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
PMID:14661054
http://purl.org/obo/owl/PMID#PMID_14661054
GOC:vk
http://purl.org/obo/owl/GOC#GOC_vk
gamma-catenin-TCF7L2 complex
cellular_component
gamma-catenin-TCF4 complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
plakoglobin-TCF4 complex
PMID:14661054
http://purl.org/obo/owl/PMID#PMID_14661054
A protein complex that contains gamma-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
GOC:vk
http://purl.org/obo/owl/GOC#GOC_vk
PMID:14661054
http://purl.org/obo/owl/PMID#PMID_14661054
Slit-Robo signaling complex
cellular_component
A protein-carbohydrate complex that consists of a transmembrane roundabout (Robo) receptor, an extracellular Slit ligand and heparin/heparan sulfate.
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
PMID:18359766
http://purl.org/obo/owl/PMID#PMID_18359766
PMID:17062560
http://purl.org/obo/owl/PMID#PMID_17062560
Slit-Robo signalling complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
endocytic vesicle lumen
cellular_component
The volume enclosed by the membrane of an endocytic vesicle.
GOC:pde
http://purl.org/obo/owl/GOC#GOC_pde
sensory dendrite
cellular_component
A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:kmv
http://purl.org/obo/owl/GOC#GOC_kmv
GOC:dos
http://purl.org/obo/owl/GOC#GOC_dos
NADH dehydrogenase complex (plastoquinone)
cellular_component
An NADH dehydrogenase complex that catalyzes the transfer of electrons to plastoquinone. The complex is involved in the non-photochemical reduction of plastoquinones and the cyclic electron transport around photosystem I, and is found in plastid thylakoids.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
DOI:10.1078/0176-1617-00593
http://purl.org/obo/owl/DOI#DOI_10.1078/0176-1617-00593
horsetail nucleus
cellular_component
The elongated nucleus which forms during the rapid oscillatory movement at meiotic prophase; characterized in Schizosaccharomyces pombe.
PMID:15030757
http://purl.org/obo/owl/PMID#PMID_15030757
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
horsetail nucleus leading edge
cellular_component
The part of the horsetail nucleus where telomeres cluster under the SPB and that leads horsetail movement. The horsetail nucleus is the elongated nucleus which forms during the rapid oscillatory movement at meiotic prophase; characterized in Schizosaccharomyces pombe.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:15030757
http://purl.org/obo/owl/PMID#PMID_15030757
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
IgG immunoglobulin complex
Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species.
cellular_component
IgG2b
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgG immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgG1
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgG2
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgG2a
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgG4
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgG3
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgG2c
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgG immunoglobulin complex, circulating
Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species.
cellular_component
IgG2 antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgG1 antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgG2b antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgG2a antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgG4 antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgG antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgG2c antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgG3 antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgG B cell receptor complex
Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species.
cellular_component
surface IgG4
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
membrane-bound IgG2c
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
surface IgG2
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
An IgG immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
surface IgG1
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
surface IgG2c
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
membrane-bound IgG
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
surface IgG
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
membrane-bound IgG1
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
surface IgG3
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
membrane-bound IgG4
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
surface IgG2a
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
membrane-bound IgG2
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
membrane-bound IgG3
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
membrane-bound IgG2a
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
surface IgG2b
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
membrane-bound IgG2b
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgD immunoglobulin complex
Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
cellular_component
A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgD immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
PMID:11282392
http://purl.org/obo/owl/PMID#PMID_11282392
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
IgD immunoglobulin complex, circulating
Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
cellular_component
IgD antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
PMID:11282392
http://purl.org/obo/owl/PMID#PMID_11282392
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgD B cell receptor complex
Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
cellular_component
An IgD immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
PMID:11282392
http://purl.org/obo/owl/PMID#PMID_11282392
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
surface IgD
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
membrane-bound IgD
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgD immunoglobulin complex, GPI-anchored
Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
cellular_component
A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and bound via a GPI-anchor to the plasma membrane of B cells.
PMID:11282392
http://purl.org/obo/owl/PMID#PMID_11282392
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
GPI-anchored IgD
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgE immunoglobulin complex
Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
cellular_component
A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgE immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgE immunoglobulin complex, circulating
Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
cellular_component
IgE antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgE B cell receptor complex
Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
cellular_component
membrane-bound IgE
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
surface IgE
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
An IgE immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgA immunoglobulin complex
Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
cellular_component
IgA1 antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgA2 antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A protein complex composed of two identical immunoglobulin heavy chains of the IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
PMID:16362985
http://purl.org/obo/owl/PMID#PMID_16362985
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgA immunoglobulin complex, circulating
Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
cellular_component
IgA antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgA2 antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgA1 antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
PMID:16362985
http://purl.org/obo/owl/PMID#PMID_16362985
IgA B cell receptor complex
Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
cellular_component
surface IgA2
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
surface IgA1
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
membrane-bound IgA
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
membrane-bound IgA1
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
An IgA immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
PMID:16362985
http://purl.org/obo/owl/PMID#PMID_16362985
surface IgA
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
membrane-bound IgA2
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
monomeric IgA immunoglobulin complex
Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
cellular_component
A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
PMID:16362985
http://purl.org/obo/owl/PMID#PMID_16362985
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
monomeric IgA2 antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
monomeric IgA antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
monomeric IgA1 antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
polymeric IgA immunoglobulin complex
Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a polymeric forms.
cellular_component
pIgA antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
polymeric IgA1 antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
pIgA1 antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
polymeric IgA antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A protein complex composed of two, three, or four monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through disulfide binded monomers of J chain acting as a bridge. Each IgA monomer consists of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds. Dimeric IgA is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
PMID:16362985
http://purl.org/obo/owl/PMID#PMID_16362985
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
dimeric IgA immunoglobulin complex
Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a dimeric form.
cellular_component
dimeric IgA antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A protein complex composed of two monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through a disulfide binded monomer of J chain acting as a bridge. Each IgA monomer consists of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds. Dimeric IgA is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
PMID:16362985
http://purl.org/obo/owl/PMID#PMID_16362985
dimeric IgA1 antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
secretory IgA immunoglobulin complex
Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. In human only the IgA1 isotype in the polymeric form is capable of becoming secretory IgA.
cellular_component
sIgA1 antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
secretory IgA antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
sIgA antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A polymeric IgA immunoglobulin complex that is complexed with one chain of secretory component (SC). Polymeric IgA is present in mucosal areas, having been transported via a transcytosis mechanism in mucosal epithelial cells relying on the polymeric Ig receptor, a portion of which then remains bound to the polymeric IgA as secretory component.
PMID:16362985
http://purl.org/obo/owl/PMID#PMID_16362985
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
secretory dimeric IgA immunoglobulin complex
Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a dimeric form.
cellular_component
A dimeric form of secretory IgA immunoglobulin complex.
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
PMID:16362985
http://purl.org/obo/owl/PMID#PMID_16362985
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
secretory dimeric IgA antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
secretory dimeric IgA1 antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgM immunoglobulin complex
Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
cellular_component
A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
PMID:20176268
http://purl.org/obo/owl/PMID#PMID_20176268
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgM immunoglobulin complex, circulating
Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
cellular_component
IgM antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A polymer of five or six IgM core units each composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds; the individual IgM core units are held together via disulfide bonds with a single J chain polypeptide acting as a bridge between two of the polymeric units. Circulating IgM is present in the extracellular space, in mucosal areas or other tissues, or in the blood or lymph.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
PMID:20176268
http://purl.org/obo/owl/PMID#PMID_20176268
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
IgM B cell receptor complex
Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
cellular_component
membrane-bound IgM
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
surface IgM
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
An IgM immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
PMID:20176268
http://purl.org/obo/owl/PMID#PMID_20176268
pentameric IgM immunoglobulin complex
Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
cellular_component
pentameric IgM antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A circulating form of IgM consisting of a pentamer of IgM core units with a single J chain polypeptide.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
PMID:20176268
http://purl.org/obo/owl/PMID#PMID_20176268
hexameric IgM immunoglobulin complex
Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
cellular_component
hexameric IgM antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A circulating form of IgM consisting of a hexamer of IgM core units with a single J chain polypeptide.
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
PMID:20176268
http://purl.org/obo/owl/PMID#PMID_20176268
IgW immunoglobulin complex
Note that an IgW immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgW is found in fish.
cellular_component
A protein complex composed of two identical immunoglobulin heavy chains of the IgW isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgW immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgX immunoglobulin complex
Note that an IgX immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgX is found in amphibians.
cellular_component
A protein complex composed of two identical immunoglobulin heavy chains of the IgX isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgX immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgY immunoglobulin complex
Note that an IgY immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgY is found in amphibians, reptiles, and birds.
cellular_component
A protein complex composed of two identical immunoglobulin heavy chains of the IgY isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgY immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
IgZ immunoglobulin complex
Note that an IgZ immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgZ is found in bony fish, and called IgT in certain species, such as trout.
cellular_component
IgT immunoglobulin complex
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
IgT antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
IgZ antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A protein complex composed of two identical immunoglobulin heavy chains of the IgZ isotype and two identical immunoglobulin light chains, held together by disulfide bonds. The IgZ isotype is also known as the IgT isotype in certain species of fish.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
heavy chain immunoglobulin complex
Note that a heavy chain immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgNAR is found in serum of cartilaginous fish as a heavy chain dimer without immunoglobulin light chains. Note that HCab is found in camels as a heavy chain dimer without immunoglobulin light chains.
cellular_component
IgNAR antibody
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
A protein complex composed of two identical immunoglobulin heavy chains of the IgNAR isotype held together by disulfide bonds and lacking immunoglobulin light chains.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
ISBN:0781765196
http://purl.org/obo/owl/ISBN#ISBN_0781765196
PMID:12543123
http://purl.org/obo/owl/PMID#PMID_12543123
PMID:16051357
http://purl.org/obo/owl/PMID#PMID_16051357
IgNAR immunoglobulin complex
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
Ig NAR immunoglobulin complex
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
HCab
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
WINAC complex
cellular_component
A SWI/SNF-type complex that directly interacts with the vitamin D receptor (VDR) through the Williams syndrome transcription factor (WSTF), and mediates the recruitment of unliganded VDR to VDR target sites in promoters. The WINAC complex contains at least 13 subunits, including WSTF, several SWI/SNF components, and DNA replication-related factors.
PMID:12837248
http://purl.org/obo/owl/PMID#PMID_12837248
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
endoplasmic reticulum cisternal network
cellular_component
An endoplasmic reticulum part that comprises the membranes with low curvature in cross-section.
PMID:20434336
http://purl.org/obo/owl/PMID#PMID_20434336
PMID:16469703
http://purl.org/obo/owl/PMID#PMID_16469703
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
ER cisternal network
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
endoplasmic reticulum tubular network
cellular_component
An endoplasmic reticulum part that comprises the membranes with high curvature in cross-section.
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:16469703
http://purl.org/obo/owl/PMID#PMID_16469703
PMID:20434336
http://purl.org/obo/owl/PMID#PMID_20434336
ER tubular network
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
LUBAC complex
cellular_component
A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targets. In human the complex consists of RBCK1, RNF31 and SHARPIN, and has an MW of approximately 600 kDa, suggesting a heteromultimeric assembly of its subunits. LUBAC stands for Linear Ubiquitin Chain Assembly Complex.
PMID:19136968
http://purl.org/obo/owl/PMID#PMID_19136968
PMID:21455180
http://purl.org/obo/owl/PMID#PMID_21455180
GOC:sp
http://purl.org/obo/owl/GOC#GOC_sp
PMID:17006537
http://purl.org/obo/owl/PMID#PMID_17006537
satellite fibril
cellular_component
An axoneme part that is found in the flagella of mammalian sperm and is located in the middle piece between the outer dense fibers (on the concave side of outer dense fibers as seen in cross-section).
PMID:20108326
http://purl.org/obo/owl/PMID#PMID_20108326
GOC:sl
http://purl.org/obo/owl/GOC#GOC_sl
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
MMXD complex
cellular_component
MMS19-MIP18-XPD complex
PMID:20797633
http://purl.org/obo/owl/PMID#PMID_20797633
GOC:sp
http://purl.org/obo/owl/GOC#GOC_sp
A protein complex that contains the proteins MMS19, MIP18 and XPD, localizes to mitotic spindle during mitosis, and is required for proper chromosome segregation.
PMID:20797633
http://purl.org/obo/owl/PMID#PMID_20797633
GOC:sp
http://purl.org/obo/owl/GOC#GOC_sp
BAT3 complex
cellular_component
An ER membrane insertion complex that acts by facilitating tail-anchored protein capture by ASNA1/TRC40. In mammals the complex contains Bat3, TRC35 and Ubl4A.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:20676083
http://purl.org/obo/owl/PMID#PMID_20676083
GOC:sp
http://purl.org/obo/owl/GOC#GOC_sp
DUBm complex
cellular_component
deubiquitination module
PMID:19226466
http://purl.org/obo/owl/PMID#PMID_19226466
deubiquitinating module
PMID:20395473
http://purl.org/obo/owl/PMID#PMID_20395473
GOC:jp
http://purl.org/obo/owl/GOC#GOC_jp
A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p.
PMID:20395473
http://purl.org/obo/owl/PMID#PMID_20395473
PMID:19226466
http://purl.org/obo/owl/PMID#PMID_19226466
SAGA DUBm complex
GOC:jp
http://purl.org/obo/owl/GOC#GOC_jp
FANCM-MHF complex
cellular_component
A protein complex contains the proteins FANCM and MHF, or their orthologs, plays an essential role in DNA remodeling, protects replication forks, and is conserved in eukaryotes.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:20347428
http://purl.org/obo/owl/PMID#PMID_20347428
prominosome
cellular_component
prominin-containing extracellular membrane vesicle
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
An extracellular membrane-bounded vesicle that contains prominin proteins (in mouse Prom1/CD33 or Prom2) and are found in body fluids including ventricular fluid, saliva, urine and seminal fluid. In the ventricular fluid of the developing mouse brain two major classes of these particles have been observed (P2 particles of 500-1000 nm and P4 particles of 50-80 nm) which likely originate from microvilli, primary cilia and/or the midbody of neuroepithelial cells. The physiological role is not known.
PMID:17109118
http://purl.org/obo/owl/PMID#PMID_17109118
PMID:17283184
http://purl.org/obo/owl/PMID#PMID_17283184
PMID:15976444
http://purl.org/obo/owl/PMID#PMID_15976444
cleavage body
cellular_component
A nuclear body that contains proteins involved in pre-mRNA 3'-end cleavage and polyadenylation, such as DDX1, CSTF2 and CPSFs, as well as the transcription factors TFIIE and TFIIF. Cleavage bodies are localized adjacent to Cajal bodies and are involved in mRNA3'-end processing.
PMID:10564273
http://purl.org/obo/owl/PMID#PMID_10564273
PMID:11598190
http://purl.org/obo/owl/PMID#PMID_11598190
PMID:8654386
http://purl.org/obo/owl/PMID#PMID_8654386
XPC complex
cellular_component
A nucleotide-excision repair complex that is involved in damage sensing during global genome nucleotide excision repair (GG-NER). It is part of the pre-incision (or initial recognition) complex bound to sites of DNA damage. In human, it is composed of XPC, RAD23B and CETN2.
PMID:11279143
http://purl.org/obo/owl/PMID#PMID_11279143
PMID:15964821
http://purl.org/obo/owl/PMID#PMID_15964821
PMID:19941824
http://purl.org/obo/owl/PMID#PMID_19941824
Myc-Max complex
cellular_component
A transcriptional factor complex that consists of a heterodimer of the bHLH-ZIP proteins Myc and Max.
PMID:16620031
http://purl.org/obo/owl/PMID#PMID_16620031
PMID:20170194
http://purl.org/obo/owl/PMID#PMID_20170194
PMID:16620027
http://purl.org/obo/owl/PMID#PMID_16620027
GOC:cna
http://purl.org/obo/owl/GOC#GOC_cna
cell periphery
cellular_component
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
elastic fiber
cellular_component
An extracellular matrix part that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain.
PMID:20236620
http://purl.org/obo/owl/PMID#PMID_20236620
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
elastic fibre
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
elastin fiber
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
old spindle pole body
cellular_component
The spindle pole body that exists in a cell prior to spindle pole body duplication. An old spindle pole body segregates to the daughter cell upon mitosis, and lacks active proteins involved in signaling exit from mitosis.
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:15132994
http://purl.org/obo/owl/PMID#PMID_15132994
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
old SPB
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
new spindle pole body
cellular_component
The spindle pole body that is formed by spindle pole body duplication, and to which proteins involved in mitotic exit signaling (for example, the septation initiation network in fission yeast) localize.
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:15132994
http://purl.org/obo/owl/PMID#PMID_15132994
new SPB
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
Ragulator complex
cellular_component
A protein complex that contains MAPKSP1 (MP1, Map2k1ip1), ROBLD3 (p14, Mapbpip), and C11orf59 (p18). The complex is anchored to lipid rafts in late endosome membranes via C11orf59, recruits mTORC1 to lysosomal membranes in amino acid signaling to mTORC1, and is also involved in ERK/MAPK signaling.
PMID:19177150
http://purl.org/obo/owl/PMID#PMID_19177150
PMID:20381137
http://purl.org/obo/owl/PMID#PMID_20381137
MAPKSP1/ROBLD3/C11orf59 complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
ascus epiplasm
Note that this term is an is_a child of 'extracellular region part' because it is part of the ascus that lies external to spores, each of which is a cell.
cellular_component
An extracellular part that consist of ascus cytoplasm that is not packaged into ascospores.
DOI:10.1016/S0953-7562(96)80057-8
http://purl.org/obo/owl/DOI#DOI_10.1016/S0953-7562(96)80057-8
PTW/PP1 phosphatase complex
cellular_component
A protein serine/threonine phosphatase complex that contains a catalytic subunits (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:20516061
http://purl.org/obo/owl/PMID#PMID_20516061
primary cilium
cellular_component
A cilium found on many different cell types that is typically present in a single copy per cell. A primary cilium may have a variable array of axonemal microtubules and may or may not contain molecular motors.
GOC:curators
http://purl.org/obo/owl/GOC#GOC_curators
PMID:17009929
http://purl.org/obo/owl/PMID#PMID_17009929
PMID:20144998
http://purl.org/obo/owl/PMID#PMID_20144998
ER membrane insertion complex
cellular_component
A protein complex that is involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum. TA membrane proteins, also called type II transmembrane proteins, contain a single C-terminal transmembrane region. Some ER membrane insertion complex subunits are conserved between different species such as mammals and budding yeast.
PMID:20850366
http://purl.org/obo/owl/PMID#PMID_20850366
PMID:20676083
http://purl.org/obo/owl/PMID#PMID_20676083
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
endoplasmic reticulum membrane insertion complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
TRC complex
cellular_component
An ER membrane insertion complex that contains subunits that recognize two types of transmembrane domain signals. In budding yeast the complex contains Get4p, Get5p, Sgt2p, and at least two heat shock proteins (HSPs).
PMID:20850366
http://purl.org/obo/owl/PMID#PMID_20850366
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
TMD recognition complex
PMID:20850366
http://purl.org/obo/owl/PMID#PMID_20850366
MSL complex
cellular_component
A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3.
PMID:20018852
http://purl.org/obo/owl/PMID#PMID_20018852
PMID:16227571
http://purl.org/obo/owl/PMID#PMID_16227571
host cell mitochondrial intermembrane space
cellular_component
The region between the inner and outer lipid bilayers of the host cell mitochondrial envelope.
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
host cell endosome lumen
cellular_component
host endosome lumen
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
The volume enclosed by the membranes of the host cell endosome.
GOC:ecd
http://purl.org/obo/owl/GOC#GOC_ecd
host multivesicular body
cellular_component
host cell multivesicular body
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A late endosome in which regions of the limiting host cell endosomal membrane invaginate to form internal vesicles; host membrane proteins that enter the internal vesicles are sequestered from the host cytoplasm.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
host cell Cajal body
cellular_component
coiled body of host
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
host cell coiled body
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A class of nuclear body in the eukaryotic host cell, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. The host is the larger of the organisms involved in a symbiotic interaction.
GOC:rph
http://purl.org/obo/owl/GOC#GOC_rph
viral assembly compartment
cellular_component
A membrane-bounded compartment that forms in the cytoplasm of virus-infected cells, in which virus assembly takes place.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
PMID:20374631
http://purl.org/obo/owl/PMID#PMID_20374631
viral assembly site
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
virion assembly compartment
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
host cell viral assembly compartment
cellular_component
A membrane-bounded compartment that forms in the cytoplasm of the host cell, in which virus assembly takes place.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
PMID:20374631
http://purl.org/obo/owl/PMID#PMID_20374631
host cell virion assembly compartment
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
host cell viral assembly site
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
perineuronal net
cellular_component
PNN
GOC:sl
http://purl.org/obo/owl/GOC#GOC_sl
A dense extracellular matrix (ECM) structure that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain.
PMID:18364019
http://purl.org/obo/owl/PMID#PMID_18364019
GOC:sl
http://purl.org/obo/owl/GOC#GOC_sl
interleukin-23 receptor complex
cellular_component
IL-23 receptor complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
A protein complex that binds interleukin-23. The complex comprises two subunits, including the same beta subunit found in the interleukin-12 receptor.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:12023369
http://purl.org/obo/owl/PMID#PMID_12023369
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
ER membrane protein complex
cellular_component
A transmembrane protein complex that is involved in protein folding in the endoplasmic reticulum. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6.
PMID:19325107
http://purl.org/obo/owl/PMID#PMID_19325107
GOC:dgf
http://purl.org/obo/owl/GOC#GOC_dgf
endoplasmic reticulum membrane protein complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
EMC
other organism presynaptic membrane
cellular_component
A presynaptic membrane that is part of another organism, i.e. a secondary organism with which the first organism is interacting. A presynaptic membrane is specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
IPAF inflammasome complex
cellular_component
A protein complex that consists of three components, IPAF, NAIP and caspase-1, and includes among its functions the sensing of flagellin derived from Legionella pneumophila, Salmonella typhimurium, Pseudomonas aeruginosa and Shigella flexneri.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
GOC:vp
http://purl.org/obo/owl/GOC#GOC_vp
PMID:20303873
http://purl.org/obo/owl/PMID#PMID_20303873
NLRP1 inflammasome complex
cellular_component
NALP1 inflammasome complex
A protein complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential.
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
GOC:vp
http://purl.org/obo/owl/GOC#GOC_vp
PMID:20303873
http://purl.org/obo/owl/PMID#PMID_20303873
NLRP3 inflammasome complex
cellular_component
NALP3 inflammasome complex
A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
GOC:add
http://purl.org/obo/owl/GOC#GOC_add
PMID:20303873
http://purl.org/obo/owl/PMID#PMID_20303873
GOC:vp
http://purl.org/obo/owl/GOC#GOC_vp
blood microparticle
Note that this heterodimeric cytokine utilizes the IL-12p35 subunit as its alpha chain, which is also used by IL-35 as its alpha chain, and utilizes the IL-12p40 subunit as its beta chain, which is also used by IL-23 as its beta chain.
cellular_component
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
PMID:16373184
http://purl.org/obo/owl/PMID#PMID_16373184
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
cell membrane microparticle
PMID:16373184
http://purl.org/obo/owl/PMID#PMID_16373184
endothelial microparticle
Note that this heterodimeric cytokine utilizes the IL-12p35 subunit as its alpha chain, which is also used by IL-35 as its alpha chain, and utilizes the IL-12p40 subunit as its beta chain, which is also used by IL-23 as its beta chain.
cellular_component
A blood microparticle that is derived from, and contains membrane receptors as well as other proteins characteristic of, an endothelial cell.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
PMID:16373184
http://purl.org/obo/owl/PMID#PMID_16373184
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
box H/ACA RNP complex
cellular_component
A ribonucleoprotein complex that contains an RNA of the box H/ACA type, a subtype of the small nucleolar RNA (snoRNA) family. RNA pseudouridylation (isomerization of uridine to pseudouridine) is the major, and most likely the ancestral, function of H/ACA RNPs, although some have evolved other functions. Pseudouridylation targets include both large and small ribosomal RNAs (rRNAs), and on U2 small nuclear RNA (U2 snRNA).
PMID:20227365
http://purl.org/obo/owl/PMID#PMID_20227365
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:17284456
http://purl.org/obo/owl/PMID#PMID_17284456
box H/ACA snoRNP pseudouridylase complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
sRNP complex
PMID:17284456
http://purl.org/obo/owl/PMID#PMID_17284456
PMID:20227365
http://purl.org/obo/owl/PMID#PMID_20227365
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
box H/ACA scaRNP complex
cellular_component
A box H/ACA RNP complex that is located in the Cajal body of the nucleoplasm. In higher eukaryotes, box H/ACA RNP located in Cajal bodies mediate pseudouridylation of spliceosomal snRNAs.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:20227365
http://purl.org/obo/owl/PMID#PMID_20227365
PMID:17284456
http://purl.org/obo/owl/PMID#PMID_17284456
nucleoplasmic box H/ACA RNP pseudouridylase complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:20227365
http://purl.org/obo/owl/PMID#PMID_20227365
tRNA-splicing ligase complex
cellular_component
A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester.
GOC:sp
http://purl.org/obo/owl/GOC#GOC_sp
PMID:21311021
http://purl.org/obo/owl/PMID#PMID_21311021
tRNA splicing ligase complex
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
MetaCyc:ENTMULTI-CPLX
http://purl.org/obo/owl/MetaCyc#MetaCyc_ENTMULTI-CPLX
mitotic spindle
cellular_component
A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
PMID:18367542
http://purl.org/obo/owl/PMID#PMID_18367542
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:11408572
http://purl.org/obo/owl/PMID#PMID_11408572
PMID:8027178
http://purl.org/obo/owl/PMID#PMID_8027178
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
meiotic spindle
cellular_component
A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
PMID:18367542
http://purl.org/obo/owl/PMID#PMID_18367542
PMID:11408572
http://purl.org/obo/owl/PMID#PMID_11408572
PMID:8027178
http://purl.org/obo/owl/PMID#PMID_8027178
host cell PML body
cellular_component
A nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia) located within a cell of a host organism.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
GOC:jl
http://purl.org/obo/owl/GOC#GOC_jl
host cell PML nuclear body
host cell PML NB
CUL4 RING ubiquitin ligase complex
cellular_component
A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.
PMID:16792691
http://purl.org/obo/owl/PMID#PMID_16792691
PMID:18223036
http://purl.org/obo/owl/PMID#PMID_18223036
PMID:18552200
http://purl.org/obo/owl/PMID#PMID_18552200
signal recognition particle, chloroplast targeting
cellular_component
A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to the chloroplast.
PMID:17513500
http://purl.org/obo/owl/PMID#PMID_17513500
tubovesicular membrane network
cellular_component
A complex, symbiont-induced host-derived organelle that is comprised of multiple protein and lipid domains.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
TVN
TVM network
haustorium
See also: extrahaustorial matrix ; GO:0085036 and extrahaustorial membrane ; GO:0085037.
cellular_component
A projection from a cell or tissue that penetrates the host's cell wall and invaginates the host cell membrane.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
extrahaustorial matrix
See also: haustorium ; GO:0085035 and extrahaustorial membrane ; GO:0085037.
cellular_component
The space between the symbiont plasma membrane and the extrahaustorial membrane of the host.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
extrahaustorial membrane
See also: haustorium ; GO:0085035 and extrahaustorial matrix ; GO:0085036.
cellular_component
The membrane surrounding the symbiont haustorium during symbiosis, derived from the host plasma membrane.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
extra-invasive hyphal membrane
See also: extra-invasive hyphal space ; GO:0085040.
cellular_component
A host-derived membrane surrounding the symbiont invasive hypha during symbiosis.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
extra-invasive hyphal space
See also: 'extra-invasive hyphal membrane ; GO:0085039'.
cellular_component
The space between the symbiont plasma membrane and the extra-invasive hyphal membrane.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
arbuscule
See also: periarbuscular membrane ; GO:0085042.
cellular_component
Highly branched symbiont haustoria within host root cortex cells, responsible for nutrient exchange.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
periarbuscular membrane
See also: arbuscule ; GO:0085041.
cellular_component
A host-derived membrane surrounding the symbiont arbuscule during symbiosis.
GOC:pamgo_curators
http://purl.org/obo/owl/GOC#GOC_pamgo_curators
lysosomal glycocalyx
cellular_component
The polysaccharide-based coating on the inner side of a lysosomal membrane that protects it from digestion by lysosomal enzymes.
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
GOC:dph
http://purl.org/obo/owl/GOC#GOC_dph
GOC:ascb_2009
http://purl.org/obo/owl/GOC#GOC_ascb_2009
plant cell papilla
Part of papilla cell (PO:0025166), which is a shoot epidermal cell (PO:0025165) in plants. Replaces the obsolete term papillae (PO:0002001).
cellular_component
A cell projection that is a short, rounded projection from a plant epidermal cell.
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
leaf papilla
Part of leaf papilla cell (PO:0025167).
cellular_component
A plant cell papilla that is part of a leaf papilla cell.
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
stigma papilla
Part of stigma papilla cell (PO:0025168).
cellular_component
A plant cell papilla that is part of a stigma papilla cell.
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
pollen tube tip
cellular_component
The region at growing end of the pollen tube cell, where polarized growth occurs.
PO:0025281
http://purl.org/obo/owl/PO#PO_0025281
PO:0025195
http://purl.org/obo/owl/PO#PO_0025195
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
unicellular trichome branch
Unicellular trichome branch is part of unicellular trichome, which is a narrow synonym of trichome cell (PO:0008030). For a cell that forms a branch of a multicellular trichome, see multicellular trichome branch cell (PO:0025163).
cellular_component
A cell projection part that is a branch of a unicellular trichome.
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
pollen tube
Carries the male gametes to into or near the ovule. May be branched in gymnosperms. This term replaces the obsolete term PO:0006345. Part of pollen tube cell (PO:0025195).
cellular_component
A tubular cell projection that is part of a pollen tube cell and extends from a pollen grain.
PO:0025195
http://purl.org/obo/owl/PO#PO_0025195
PO:0025281
http://purl.org/obo/owl/PO#PO_0025281
GOC:tb
http://purl.org/obo/owl/GOC#GOC_tb
mitochondrial inner boundary membrane
cellular_component
The portion of the mitochondrial inner membrane that is not invaginated to form cristae. The inner boundary membrane lies parallel to the outer membrane.
PMID:16054341
http://purl.org/obo/owl/PMID#PMID_16054341
PMID:19019989
http://purl.org/obo/owl/PMID#PMID_19019989
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
phagocytic vesicle lumen
cellular_component
The volume enclosed by the membrane of a phagocytic vesicle.
GOC:rs
http://purl.org/obo/owl/GOC#GOC_rs
microtubule-based flagellar cytoplasm
cellular_component
microtubule-based flagellum matrix
All of the contents of a microtubule-based flagellum, excluding the plasma membrane surrounding the flagellum.
PMID:17895364
http://purl.org/obo/owl/PMID#PMID_17895364
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
microtubule-based flagellum cytoplasm
microtubule-based flagellar matrix
bacterial-type flagellar cytoplasm
cellular_component
bacterial-type flagellum cytoplasm
All of the contents of a bacterial-type flagellum, excluding the plasma membrane surrounding the flagellum.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
MPP7-DLG1-LIN7 complex
cellular_component
A heterotrimeric protein complex formed by the association of MMP7, DLG1 and either LIN7A or LIN7C; regulates the stability and localization of DLG1 to cell junctions.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
PMID:17237226
http://purl.org/obo/owl/PMID#PMID_17237226
perinuclear endoplasmic reticulum
cellular_component
The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes.
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
GOC:pr
http://purl.org/obo/owl/GOC#GOC_pr
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
perinuclear ER
extrinsic to fungal-type vacuolar membrane
cellular_component
Loosely bound to one surface of the fungal-type vacuolar membrane, but not integrated into the hydrophobic region.
GOC:jh
http://purl.org/obo/owl/GOC#GOC_jh
PMID:21454883
http://purl.org/obo/owl/PMID#PMID_21454883
DNA replication termination region
cellular_component
A chromosomal region that contains fork pausing elements influencing the progression and merging of DNA replication forks.
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
PMID:20797631
http://purl.org/obo/owl/PMID#PMID_20797631
GOC:pr
http://purl.org/obo/owl/GOC#GOC_pr
TER
TRAF2-GSTP1 complex
cellular_component
A protein complex comprising tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and glutathione S-transferase pi 1 (GSTP1). This complex is thought to disrupt the TNF signaling cascade, thus down-regulating inflammatory responses.
PMID:16636664
http://purl.org/obo/owl/PMID#PMID_16636664
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
CRLF-CLCF1 complex
cellular_component
A heterodimeric protein complex that is composed of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene) and cytokine receptor-like factor 1 (product of the CRLF gene) and is secreted into the extracellular space. The CRLF-CLCF1 complex is a ligand for the ciliary neurotrophic factor (CNTF) receptor complex.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
PMID:10966616
http://purl.org/obo/owl/PMID#PMID_10966616
CLF-CLC complex
CNTFR-CLCF1 complex
cellular_component
sCNTFR-CLC complex
A protein complex that is composed of two soluble ciliary neurotrophic factor receptor alpha subunits (product of the CNTFR gene) and two molecules of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene). The complex is secreted into the extracellular space.
PMID:11285233
http://purl.org/obo/owl/PMID#PMID_11285233
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
synaptic membrane
cellular_component
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
GOC:BHF
http://purl.org/obo/owl/GOC#GOC_BHF
PMID:20410104
http://purl.org/obo/owl/PMID#PMID_20410104
interferon regulatory factor complex
cellular_component
IRF complex
A protein complex that consists of two interferon regulatory proteins (IRFs); may be homodimeric or heterodimeric. The activation of a latent closed conformation of IRF in the cytoplasm is triggered by phosphorylation of Ser/Thr residues in a C-terminal region. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit.
GOC:cna
http://purl.org/obo/owl/GOC#GOC_cna
PMID:20043992
http://purl.org/obo/owl/PMID#PMID_20043992
interferon regulatory factor 3 complex
cellular_component
An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 3.
Reactome:REACT_7146
http://purl.org/obo/owl/Reactome#Reactome_REACT_7146
GOC:cna
http://purl.org/obo/owl/GOC#GOC_cna
PMID:14556004
http://purl.org/obo/owl/PMID#PMID_14556004
PMID:12855817
http://purl.org/obo/owl/PMID#PMID_12855817
IRF3:IRF3 complex
interferon regulatory factor 5 complex
cellular_component
IRF5:IRF5 complex
An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 5.
PMID:16751392
http://purl.org/obo/owl/PMID#PMID_16751392
PMID:12138184
http://purl.org/obo/owl/PMID#PMID_12138184
GOC:cna
http://purl.org/obo/owl/GOC#GOC_cna
interferon regulatory factor 7 complex
cellular_component
IRF7:IRF7 complex
An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 7.
PMID:18068231
http://purl.org/obo/owl/PMID#PMID_18068231
GOC:cna
http://purl.org/obo/owl/GOC#GOC_cna
Reactome:REACT_21965
http://purl.org/obo/owl/Reactome#Reactome_REACT_21965
interferon regulatory factor 3-interferon regulatory factor 7 complex
cellular_component
IRF3:IRF7 complex
An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 7.
GOC:cna
http://purl.org/obo/owl/GOC#GOC_cna
PMID:18068231
http://purl.org/obo/owl/PMID#PMID_18068231
Reactome:REACT_26957
http://purl.org/obo/owl/Reactome#Reactome_REACT_26957
transforming growth factor beta activated kinase 1 complex
cellular_component
A protein complex that possesses protein kinase activity and activates the I-kappa B kinase complex (IKK) and mitogen-activated protein (MAP) kinases in response to TRAF6 signaling. It comprises the catalytic subunit TAK1 complexed to the regulatory subunits, termed TABs (TAK1-binding subunits).
GOC:cna
http://purl.org/obo/owl/GOC#GOC_cna
PMID:16410796
http://purl.org/obo/owl/PMID#PMID_16410796
PMID:18021073
http://purl.org/obo/owl/PMID#PMID_18021073
PMID:17496917
http://purl.org/obo/owl/PMID#PMID_17496917
TAK1 kinase complex
FAl1-SGD1 complex
cellular_component
A protein complex involved in the 18S rRNA biogenesis. In S. cerevisiae this complex consists of Fal1p and Sgd1p and in humans this complex consists of NOM1 and eIF4AIII subunits.
PMID:21576267
http://purl.org/obo/owl/PMID#PMID_21576267
GOC:rb
http://purl.org/obo/owl/GOC#GOC_rb
interferon regulatory factor 3-interferon regulatory factor 5 complex
cellular_component
An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 5.
GOC:cna
http://purl.org/obo/owl/GOC#GOC_cna
PMID:12138184
http://purl.org/obo/owl/PMID#PMID_12138184
IRF3:IRF5 complex
cyclin A1-CDK1 complex
cellular_component
A protein complex consisting of cyclin A1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
PMID:15935619
http://purl.org/obo/owl/PMID#PMID_15935619
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
cyclin A2-CDK1 complex
cellular_component
A protein complex consisting of cyclin A2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
PMID:15935619
http://purl.org/obo/owl/PMID#PMID_15935619
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
cyclin A1-CDK2 complex
cellular_component
A protein complex consisting of cyclin A1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
PMID:15935619
http://purl.org/obo/owl/PMID#PMID_15935619
cyclin A2-CDK2 complex
cellular_component
A protein complex consisting of cyclin A2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
PMID:15935619
http://purl.org/obo/owl/PMID#PMID_15935619
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
cyclin B1-CDK1 complex
cellular_component
A protein complex consisting of cyclin B1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
PMID:15935619
http://purl.org/obo/owl/PMID#PMID_15935619
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
cyclin B2-CDK1 complex
cellular_component
A protein complex consisting of cyclin B2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
PMID:15935619
http://purl.org/obo/owl/PMID#PMID_15935619
cyclin B3-CDK2 complex
cellular_component
A protein complex consisting of cyclin B3 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
PMID:15935619
http://purl.org/obo/owl/PMID#PMID_15935619
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
cyclin D1-CDK4 complex
cellular_component
A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
PR:000026740
http://purl.org/obo/owl/PR#PR_000026740
PMID:15935619
http://purl.org/obo/owl/PMID#PMID_15935619
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
cyclin D2-CDK4 complex
cellular_component
A protein complex consisting of cyclin D2 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
PMID:15935619
http://purl.org/obo/owl/PMID#PMID_15935619
cyclin D3-CDK4 complex
cellular_component
A protein complex consisting of cyclin D3 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
PMID:15935619
http://purl.org/obo/owl/PMID#PMID_15935619
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
cyclin D1-CDK6 complex
cellular_component
A protein complex consisting of cyclin D1 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
PMID:15935619
http://purl.org/obo/owl/PMID#PMID_15935619
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
cyclin D2-CDK6 complex
cellular_component
A protein complex consisting of cyclin D2 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
PMID:15935619
http://purl.org/obo/owl/PMID#PMID_15935619
cyclin D3-CDK6 complex
cellular_component
A protein complex consisting of cyclin D3 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
PMID:15935619
http://purl.org/obo/owl/PMID#PMID_15935619
cyclin E1-CDK2 complex
cellular_component
A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
PR:000026745
http://purl.org/obo/owl/PR#PR_000026745
PMID:15935619
http://purl.org/obo/owl/PMID#PMID_15935619
cyclin E2-CDK2 complex
cellular_component
A protein complex consisting of cyclin E2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
PMID:15935619
http://purl.org/obo/owl/PMID#PMID_15935619
PR:000026746
http://purl.org/obo/owl/PR#PR_000026746
Bcl-2 family protein complex
cellular_component
A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed.
PMID:14634621
http://purl.org/obo/owl/PMID#PMID_14634621
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
BAD-BCL-xl complex
cellular_component
A heterodimeric protein complex consisting of BAD and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.
PMID:14634621
http://purl.org/obo/owl/PMID#PMID_14634621
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
BAD-BCL-2 complex
cellular_component
A heterodimeric protein complex consisting of BAD and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators.
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
PMID:14634621
http://purl.org/obo/owl/PMID#PMID_14634621
BID-BCL-2 complex
cellular_component
A heterodimeric protein complex consisting of BID and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators.
PMID:14634621
http://purl.org/obo/owl/PMID#PMID_14634621
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
BIM-BCL-xl complex
cellular_component
A heterodimeric protein complex consisting of BIM and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
PMID:14634621
http://purl.org/obo/owl/PMID#PMID_14634621
BIM-BCL-2 complex
cellular_component
A heterodimeric protein complex consisting of BIM and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators.
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
PMID:14634621
http://purl.org/obo/owl/PMID#PMID_14634621
PUMA-BCL-2 complex
cellular_component
A heterodimeric protein complex consisting of PUMA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators.
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
PMID:14634621
http://purl.org/obo/owl/PMID#PMID_14634621
PUMA-BCL-xl complex
cellular_component
A heterodimeric protein complex consisting of PUMA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
PMID:14634621
http://purl.org/obo/owl/PMID#PMID_14634621
BAX complex
cellular_component
An oligomeric protein complex consisting of BAX, a member of the Bcl-2 family of anti- and proapoptotic regulators.
PMID:14634621
http://purl.org/obo/owl/PMID#PMID_14634621
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
BAK complex
cellular_component
An oligomeric protein complex consisting of BAK, a member of the Bcl-2 family of anti- and proapoptotic regulators.
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
PMID:14634621
http://purl.org/obo/owl/PMID#PMID_14634621
NOXA-BCL-xl complex
cellular_component
A heterodimeric protein complex consisting of NOXA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
PMID:14634621
http://purl.org/obo/owl/PMID#PMID_14634621
NOXA-BCL-2 complex
cellular_component
A heterodimeric protein complex consisting of NOXA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators.
PMID:14634621
http://purl.org/obo/owl/PMID#PMID_14634621
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
BCL-2 complex
cellular_component
A homodimeric protein complex consisting of BAK, a member of the Bcl-2 family of anti- and proapoptotic regulators.
GOC:so
http://purl.org/obo/owl/GOC#GOC_so
PMID:14634621
http://purl.org/obo/owl/PMID#PMID_14634621
centralspindlin complex
cellular_component
A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals).
PMID:11782313
http://purl.org/obo/owl/PMID#PMID_11782313
PMID:16236794
http://purl.org/obo/owl/PMID#PMID_16236794
GOC:ans
http://purl.org/obo/owl/GOC#GOC_ans
nuclear stress granule
cellular_component
A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress.
PMID:12865437
http://purl.org/obo/owl/PMID#PMID_12865437
PMID:10359787
http://purl.org/obo/owl/PMID#PMID_10359787
GOC:ans
http://purl.org/obo/owl/GOC#GOC_ans
AIM2 inflammasome complex
cellular_component
A protein complex that consists of AIM2, ASC, and caspase-1. AIM2 is a member of the HN-200 protein family that appears to be the sensor of cytosolic double-stranded DNA.
GOC:vp
http://purl.org/obo/owl/GOC#GOC_vp
PMID:20303873
http://purl.org/obo/owl/PMID#PMID_20303873
protease inhibitor complex
cellular_component
A heterodimeric protein complex that contains a protease inhibitor and a protease; formation of the complex inhibits protease activity.
GOC:ans
http://purl.org/obo/owl/GOC#GOC_ans
PMID:6323392
http://purl.org/obo/owl/PMID#PMID_6323392
peptidase inhibitor complex
GOC:pr
http://purl.org/obo/owl/GOC#GOC_pr
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
serine protease inhibitor complex
cellular_component
serine-type endopeptidase inhibitor complex
GOC:pr
http://purl.org/obo/owl/GOC#GOC_pr
GOC:bf
http://purl.org/obo/owl/GOC#GOC_bf
A heterodimeric protein complex that contains a serine protease inhibitor and a protease; formation of the complex inhibits serine protease activity.
PMID:6323392
http://purl.org/obo/owl/PMID#PMID_6323392
GOC:ans
http://purl.org/obo/owl/GOC#GOC_ans
serpin complex
protein C inhibitor-coagulation factor V complex
cellular_component
protein C inhibitor-F5 complex
PR:000007300
http://purl.org/obo/owl/PR#PR_000007300
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor V (F5); formation of the complex inhibits the serine protease activity of coagulation factor V.
PMID:6323392
http://purl.org/obo/owl/PMID#PMID_6323392
GOC:ans
http://purl.org/obo/owl/GOC#GOC_ans
PCI-coagulation factor V complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
plasma serine protease inhibitor-coagulation factor V complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
SERPINA5-coagulation factor V complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
serpin A5-coagulation factor V complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
protein C inhibitor-coagulation factor Xa complex
cellular_component
plasma serine protease inhibitor-coagulation factor Xa complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
serpin A5-coagulation factor Xa complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
SERPINA5-coagulation factor Xa complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
PCI-coagulation factor Xa complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor Xa (F10); formation of the complex inhibits the serine protease activity of coagulation factor Xa.
GOC:ans
http://purl.org/obo/owl/GOC#GOC_ans
PMID:6323392
http://purl.org/obo/owl/PMID#PMID_6323392
protein C inhibitor-coagulation factor XI complex
cellular_component
protein C inhibitor-F11 complex
PR:000007295
http://purl.org/obo/owl/PR#PR_000007295
plasma serine protease inhibitor-coagulation factor XI complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor XI (F11); formation of the complex inhibits the serine protease activity of coagulation factor XI.
PMID:2844223
http://purl.org/obo/owl/PMID#PMID_2844223
GOC:ans
http://purl.org/obo/owl/GOC#GOC_ans
SERPINA5-coagulation factor XI complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
serpin A5-coagulation factor XI complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
PCI-coagulation factor XI complex
PR:000014685
http://purl.org/obo/owl/PR#PR_000014685
apoptotic body
cellular_component
A fragment containing parts of a dying cell. Apoptotic bodies can be formed during the execution phase of the apoptotic process, when the cell's cytoskeleton breaks up and causes the membrane to bulge outward. These bulges may separate from the cell, taking a portion of cytoplasm with them, to become apoptotic bodies. These are then engulfed by phagocytic cells, and their components recycled.
URL:http://en.wikipedia.org/wiki/Apoptosis
http://en.wikipedia.org/wiki/Apoptosis
GOC:mtg_apoptosis
http://purl.org/obo/owl/GOC#GOC_mtg_apoptosis
URL:http://en.wikipedia.org/wiki/Bleb_(cell_biology)
http://en.wikipedia.org/wiki/Bleb_(cell_biology)
Shu complex
cellular_component
A protein complex involved in error-free DNA post-replication repair (PRR). In Saccharomyces cerevisiae the complex contains Csm2p, Psy3p, Shu1p, and Shu2p.
GOC:jh
http://purl.org/obo/owl/GOC#GOC_jh
PMID:19496932
http://purl.org/obo/owl/PMID#PMID_19496932
PMID:15654096
http://purl.org/obo/owl/PMID#PMID_15654096
tetraspanin-enriched microdomain
cellular_component
membrane tetraspanin-enriched microdomain
TEM
A pre-organized unit composed either of adhesion molecules (mainly integrins and members of the Ig superfamily), signaling receptors and/or enzyme-enriched plasma membrane domains that compartmentalizes cellular processes. Tetraspanin-enriched microdomains might be specially suited for the regulation of avidity of adhesion receptors and the compartmentalization of enzymatic activities.
GOC:ans
http://purl.org/obo/owl/GOC#GOC_ans
PMID:19709882
http://purl.org/obo/owl/PMID#PMID_19709882
PMID:21930792
http://purl.org/obo/owl/PMID#PMID_21930792
phagocytic cup lip
cellular_component
The tip or margin of the progressing circular lamella that engulfs a particle during phagocytosis. When the two lips of the cup fuse it is converted into a phagosome.
GOC:pf
http://purl.org/obo/owl/GOC#GOC_pf
PMID:20200225
http://purl.org/obo/owl/PMID#PMID_20200225
phagocytic cup base
cellular_component
The older part of the phagocytic cup where the actin cytoskeleton disassembles, allowing early incoming and outgoing vesicular trafficking.
GOC:pf
http://purl.org/obo/owl/GOC#GOC_pf
PMID:20200225
http://purl.org/obo/owl/PMID#PMID_20200225
alveolar lamellar body
cellular_component
A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant.
URL:http://en.wikipedia.org/wiki/Lamellar_granule
http://en.wikipedia.org/wiki/Lamellar_granule
GOC:cjm
http://purl.org/obo/owl/GOC#GOC_cjm
epidermal lamellar body
cellular_component
A specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function.
URL:http://en.wikipedia.org/wiki/Lamellar_granule
http://en.wikipedia.org/wiki/Lamellar_granule
GOC:cjm
http://purl.org/obo/owl/GOC#GOC_cjm
sieve area
Part of a sieve element (PO:0025406).
cellular_component
A pit-like area in the cell wall of a sieve element; contains pores lined with callose and occupied by strands of protoplasmic material that interconnect the protoplasts of contiguous sieve elements.
ISBN:0471738433
http://purl.org/obo/owl/ISBN#ISBN_0471738433
POC:curators
http://purl.org/obo/owl/POC#POC_curators
sieve plate
Typical of angiosperms. Part of sieve tube member (PO:0000289).
cellular_component
A part of the cell wall of a sieve tube member that bears one or more highly specialized sieve areas.
POC:curators
http://purl.org/obo/owl/POC#POC_curators
ISBN:0471738433
http://purl.org/obo/owl/ISBN#ISBN_0471738433
compound sieve plate
Often located on an end wall of a sieve tube member. Unspecialized sieve areas may occur on other parts of the cell.
cellular_component
A sieve plate that contains several specialized sieve areas in either a scalariform or reticulate arrangement.
POC:curators
http://purl.org/obo/owl/POC#POC_curators
ISBN:0471738433
http://purl.org/obo/owl/ISBN#ISBN_0471738433
simple sieve plate
Often located on an end wall of a sieve tube member. Unspecialized sieve areas may occur on other parts of the cell.
cellular_component
A sieve plate that contains a single specialized sieve area.
POC:curators
http://purl.org/obo/owl/POC#POC_curators
ISBN:0471738433
http://purl.org/obo/owl/ISBN#ISBN_0471738433
MADS box-forkhead transcription factor complex
cellular_component
PBF complex
A protein complex that contains a MADS-box protein and two forkhead domain proteins, and binds to and regulates transcription from promoters of genes transcribed during the M/G1 transition of the cell cycle. In Schizosaccharomyces pombe, the complex contains the MADS-box protein Mbx1 and two forkhead proteins, Sep1 and Fkh2.
GOC:mah
http://purl.org/obo/owl/GOC#GOC_mah
PMID:18057023
http://purl.org/obo/owl/PMID#PMID_18057023
PBF transcription complex
GOC:vw
http://purl.org/obo/owl/GOC#GOC_vw
pombe cell cycle box binding factor complex
PCB binding factor complex
sperm part
cellular_component
Any constituent part of a sperm, a mature male germ cell that develops from a spermatid.
GOC:cjm
http://purl.org/obo/owl/GOC#GOC_cjm
sperm connecting piece
cellular_component
The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum.
GOC:cjm
http://purl.org/obo/owl/GOC#GOC_cjm
MP:0009830
http://purl.org/obo/owl/MP#MP_0009830
sperm midpiece
cellular_component
The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece.
MP:0009831
http://purl.org/obo/owl/MP#MP_0009831
GOC:cjm
http://purl.org/obo/owl/GOC#GOC_cjm
sperm mitochondrial sheath
cellular_component
The tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum.
GOC:cjm
http://purl.org/obo/owl/GOC#GOC_cjm
MP:0009832
http://purl.org/obo/owl/MP#MP_0009832
sperm annulus
cellular_component
The ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity.
MP:0009834
http://purl.org/obo/owl/MP#MP_0009834
GOC:cjm
http://purl.org/obo/owl/GOC#GOC_cjm
sperm principal piece
cellular_component
The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece.
MP:0009836
http://purl.org/obo/owl/MP#MP_0009836
GOC:cjm
http://purl.org/obo/owl/GOC#GOC_cjm
sperm end piece
cellular_component
The short tip of the sperm flagellum, adjacent to the sperm principal piece and furthest from the sperm head, which contains only the axoneme surrounded by the plasma membrane.
GOC:sart
http://purl.org/obo/owl/GOC#GOC_sart
MP:0009837
http://purl.org/obo/owl/MP#MP_0009837
GOC:cjm
http://purl.org/obo/owl/GOC#GOC_cjm
lamellar body membrane
cellular_component
The lipid bilayer surrounding a lamellar body. A lamellar body is a membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome.
GOC:sl
http://purl.org/obo/owl/GOC#GOC_sl
PMID:11940594
http://purl.org/obo/owl/PMID#PMID_11940594
alveolar lamellar body membrane
cellular_component
The lipid bilayer surrounding an alveolar lamellar body, a specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant.
GOC:sl
http://purl.org/obo/owl/GOC#GOC_sl
PMID:11940594
http://purl.org/obo/owl/PMID#PMID_11940594
epidermal lamellar body membrane
cellular_component
The lipid bilayer surrounding an epidermal lamellar body, a specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function.
PMID:11940594
http://purl.org/obo/owl/PMID#PMID_11940594
GOC:sl
http://purl.org/obo/owl/GOC#GOC_sl
mitochondrial respiratory chain supercomplex
cellular_component
A set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, Complex II, Complex III, Complex IV, or F1-F0 ATPase) arranged to form a large supercomplex.
PMID:22342701
http://purl.org/obo/owl/PMID#PMID_22342701
PMID:21909073
http://purl.org/obo/owl/PMID#PMID_21909073
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
mitochondrial respirasome
mitochondrial respiratory supercomplex
R2TP complex
cellular_component
A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others.
PMID:15766533
http://purl.org/obo/owl/PMID#PMID_15766533
PMID:21925213
http://purl.org/obo/owl/PMID#PMID_21925213
GOC:mcc
http://purl.org/obo/owl/GOC#GOC_mcc
cytoophidium
cellular_component
A subcellular filamentary structure where CTP synthase is compartmentalized in a range of organisms including bacteria, yeast, fruit fly, rat and human.
PMID:21930098
http://purl.org/obo/owl/PMID#PMID_21930098
PMID:20513629
http://purl.org/obo/owl/PMID#PMID_20513629
URL:http://en.wikipedia.org/wiki/CTP_synthase#Cytoophidium
http://en.wikipedia.org/wiki/CTP_synthase#Cytoophidium
GOC:mag
http://purl.org/obo/owl/GOC#GOC_mag
biofilm matrix
cellular_component
A structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria.
URL:http://en.wikipedia.org/wiki/Biofilm
http://en.wikipedia.org/wiki/Biofilm
PMID:22571672
http://purl.org/obo/owl/PMID#PMID_22571672
GOC:imk
http://purl.org/obo/owl/GOC#GOC_imk
biofilm matrix part
cellular_component
Any constituent part of the biofilm matrix, a structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria.
GOC:imk
http://purl.org/obo/owl/GOC#GOC_imk
URL:http://en.wikipedia.org/wiki/Biofilm
http://en.wikipedia.org/wiki/Biofilm
PMID:22571672
http://purl.org/obo/owl/PMID#PMID_22571672
biofilm matrix surface
cellular_component
The external part of the biofilm matrix, a structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria.
GOC:imk
http://purl.org/obo/owl/GOC#GOC_imk
URL:http://en.wikipedia.org/wiki/Biofilm
http://en.wikipedia.org/wiki/Biofilm
PMID:22571672
http://purl.org/obo/owl/PMID#PMID_22571672
Aspergillus GO slim
Candida GO slim
Generic GO slim
Metagenomics GO slim
PIR GO slim
Plant GO slim
Fission yeast GO slim
Yeast GO slim
Prokaryotic GO subset
High-level terms not to be used for direct annotation
Catalytic activity terms in need of attention