part of
event
negatively_regulates
event
positively_regulates
event
regulates
event
Event
event
Pathway
event
Cell differentiation
event
The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
GO:0030154
http://purl.org/obo/owl/GO#GO_0030154
GO:0030154
http://purl.org/obo/owl/GO#GO_0030154
Biological event
event
Binding
event
Phosphorylation
event
Reversible reaction that can affect D,C,H,S,T,Y,R residues.
MI:0217
http://purl.org/obo/owl/MI#MI_0217
MI:0217
http://purl.org/obo/owl/MI#MI_0217
EC:2.7.-.-
http://purl.org/obo/owl/EC#EC_2.7.-.-
GO:0016310
http://purl.org/obo/owl/GO#GO_0016310
Dissociation
event
Inactivation
event
Activation
event
Translocation
event
The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
GO:0006810
http://purl.org/obo/owl/GO#GO_0006810
transport
GO:0006810
http://purl.org/obo/owl/GO#GO_0006810
Proteasome degradation
event
EC:3.4.25.1
http://purl.org/obo/owl/EC#EC_3.4.25.1
Cleavage of peptide bonds with very broad specificity.
EC:3.4.25.1
http://purl.org/obo/owl/EC#EC_3.4.25.1
Dephosphorylation
event
Phosphoresidues are cleaved and return D,C,H,S,T,Y or R residues.
MI:0203
http://purl.org/obo/owl/MI#MI_0203
MI:0203
http://purl.org/obo/owl/MI#MI_0203
Ubiquitination
event
Reversible reaction that create a covalent bond between a C-terminus G of ubiquitin and a K residue of the target.
MI:0220
http://purl.org/obo/owl/MI#MI_0220
EC:6.3.2.19
http://purl.org/obo/owl/EC#EC_6.3.2.19
MI:0220
http://purl.org/obo/owl/MI#MI_0220
Binding in cytosol
event
Binding in plasma membrane
event
Binding in nucleus
event
Binding in extracellular
event
Binding in nuclear membrane
event
Nuclear import
event
GO:0051170
http://purl.org/obo/owl/GO#GO_0051170
import into nucleus
nucleus import
substance nuclear import
The directed movement of substances into the nucleus.
GO:0051170
http://purl.org/obo/owl/GO#GO_0051170
Nuclear export
event
export from nucleus
nucleus export
substance nuclear export
The directed movement of substances out of the nucleus.
GO:0051168
http://purl.org/obo/owl/GO#GO_0051168
GO:0051168
http://purl.org/obo/owl/GO#GO_0051168
Activation in cytosol
event
Proteasome degradation in cytosol
event
Dephosphorylation in cytosol
event
Dissociation in cytosol
event
Inactivation in cytosol
event
Phosphorylation in cytosol
event
Ubiquitination in cytosol
event
Wnt signaling pathway
event
GO:0016055
http://purl.org/obo/owl/GO#GO_0016055
Wnt signaling pathway (Drosophila)
The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell.
GO:0016055
http://purl.org/obo/owl/GO#GO_0016055
Wnt receptor signaling pathway
GO:0016055
http://purl.org/obo/owl/GO#GO_0016055
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
KEGG:hsa04310
http://purl.org/obo/owl/KEGG#KEGG_hsa04310
Wnt signaling pathway (Mammalia)
Wnt signaling pathway (Xenopus)
Wnt signaling pathway (C. elegans)
Chemical treatment
event
Binding of Frizzled and DSH in cytosol
event
IMR:0000055
http://purl.org/obo/owl/IMR#IMR_0000055
IMR:0100755
http://purl.org/obo/owl/IMR#IMR_0100755
PubMed:14636582
http://purl.org/obo/owl/PubMed#PubMed_14636582
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
Phosphorylation of DSH by CK1 in cytosol
event
PubMed:10517632
http://purl.org/obo/owl/PubMed#PubMed_10517632
IMR:0100809
http://purl.org/obo/owl/IMR#IMR_0100809
IMR:0100755
http://purl.org/obo/owl/IMR#IMR_0100755
PubMed:10656974
http://purl.org/obo/owl/PubMed#PubMed_10656974
Inactivation of GSK3beta by DSH_p in cytosol
event
IMR:0100737
http://purl.org/obo/owl/IMR#IMR_0100737
IMR:0100755
http://purl.org/obo/owl/IMR#IMR_0100755
Complex formation of Axin, APC, GSK3beta, CK1alpha and beta catenin in cytosol
event
IMR:0100810
http://purl.org/obo/owl/IMR#IMR_0100810
PubMed:15549094
http://purl.org/obo/owl/PubMed#PubMed_15549094
IMR:0000205
http://purl.org/obo/owl/IMR#IMR_0000205
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
IMR:0100737
http://purl.org/obo/owl/IMR#IMR_0100737
IMR:0000432
http://purl.org/obo/owl/IMR#IMR_0000432
Binding in mitochondria membrane
event
Nuclear import of beta catenin
event
PubMed:15549094
http://purl.org/obo/owl/PubMed#PubMed_15549094
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
Binding of beta-catenin and TCF in inner space of nucleus
event
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
PubMed:12210516
http://purl.org/obo/owl/PubMed#PubMed_12210516
IMR:0000418
http://purl.org/obo/owl/IMR#IMR_0000418
Binding of TCF/LEF and responsive element in inner space of nucleus
event
PubMed:15549094
http://purl.org/obo/owl/PubMed#PubMed_15549094
PubMed:14755243
http://purl.org/obo/owl/PubMed#PubMed_14755243
IMR:0000418
http://purl.org/obo/owl/IMR#IMR_0000418
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
PubMed:15292219
http://purl.org/obo/owl/PubMed#PubMed_15292219
IGS:0000028
http://purl.org/obo/owl/IGS#IGS_0000028
Activation in unidentified cellular location
event
Proteasome degradation in unidentified cellular location
event
Dephosphorylation in unidentified cellular location
event
Dissociation of Axin, APC, GSK3beta, CK1alpha and beta-catenin in cytosol
event
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
PubMed:15549094
http://purl.org/obo/owl/PubMed#PubMed_15549094
IMR:0100737
http://purl.org/obo/owl/IMR#IMR_0100737
IMR:0100810
http://purl.org/obo/owl/IMR#IMR_0100810
IMR:0000432
http://purl.org/obo/owl/IMR#IMR_0000432
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
IMR:0000205
http://purl.org/obo/owl/IMR#IMR_0000205
Binding of Wnt and Frizzled in extracellular
event
PubMed:15549094
http://purl.org/obo/owl/PubMed#PubMed_15549094
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
IMR:0000055
http://purl.org/obo/owl/IMR#IMR_0000055
IMR:0000003
http://purl.org/obo/owl/IMR#IMR_0000003
PubMed:9288750
http://purl.org/obo/owl/PubMed#PubMed_9288750
Inorganic chemical treatment
event
JAK STAT pathway
IEV:0000137
event
GO:0007259
http://purl.org/obo/owl/GO#GO_0007259
KEGG:hsa04630
http://purl.org/obo/owl/KEGG#KEGG_hsa04630
The processes by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of cytokines to their cognate receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
GO:0007259
http://purl.org/obo/owl/GO#GO_0007259
Binding of cytokine and cytokine receptors and conformational change of receptors in plasma membrane
event
PubMed:9974393
http://purl.org/obo/owl/PubMed#PubMed_9974393
IMR:0000095
http://purl.org/obo/owl/IMR#IMR_0000095
IMR:0000006
http://purl.org/obo/owl/IMR#IMR_0000006
Binding of cytokine receptor and STAT in cytosol
event
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
PubMed:15541651
http://purl.org/obo/owl/PubMed#PubMed_15541651
IMR:0000095
http://purl.org/obo/owl/IMR#IMR_0000095
Dimerization of STAT in cytosol
event
The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases.
GO:0007261
http://purl.org/obo/owl/GO#GO_0007261
GO:0007261
http://purl.org/obo/owl/GO#GO_0007261
PubMed:12039028
http://purl.org/obo/owl/PubMed#PubMed_12039028
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
STAT dimerization
JAK-induced STAT protein dimerization
Nuclear import of STAT dimer
event
STAT protein nuclear translocation
PubMed:12039028
http://purl.org/obo/owl/PubMed#PubMed_12039028
The transport of dimerized STAT (Signal Transducers and Activators of Transcription) proteins into the nucleus following activation by members of the janus activated kinase (JAK) family of tyrosine kinases.
GO:0007262
http://purl.org/obo/owl/GO#GO_0007262
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
GO:0007262
http://purl.org/obo/owl/GO#GO_0007262
Binding of STAT dimer and responsive element in inner space of nucleus
event
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
PubMed:12039028
http://purl.org/obo/owl/PubMed#PubMed_12039028
IGS:0000028
http://purl.org/obo/owl/IGS#IGS_0000028
Transcription by STAT dimer in nucleus
event
PubMed:12039028
http://purl.org/obo/owl/PubMed#PubMed_12039028
PubMed:14607831
http://purl.org/obo/owl/PubMed#PubMed_14607831
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
Binding of cytokine receptor and JAK in cytosol
event
PubMed:12039028
http://purl.org/obo/owl/PubMed#PubMed_12039028
IMR:0000213
http://purl.org/obo/owl/IMR#IMR_0000213
IMR:0000095
http://purl.org/obo/owl/IMR#IMR_0000095
Autophosphorylation of Jak in cytosol
event
PubMed:9974393
http://purl.org/obo/owl/PubMed#PubMed_9974393
GO:0042976
http://purl.org/obo/owl/GO#GO_0042976
IMR:0000213
http://purl.org/obo/owl/IMR#IMR_0000213
positive regulation of JAK protein activity by tyrosine phosphorylation
activation of JAK protein
The process of introducing a phosphoric group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.
GO:0042976
http://purl.org/obo/owl/GO#GO_0042976
Phosphorylation of cytokine receptor by Jak in cytosol
event
IMR:0000213
http://purl.org/obo/owl/IMR#IMR_0000213
PubMed:15541651
http://purl.org/obo/owl/PubMed#PubMed_15541651
IMR:0000095
http://purl.org/obo/owl/IMR#IMR_0000095
Bad inactivation signaling
event
Bad phosphorylation signaling
Bad inactivation signaling
PKA-Bad signaling
event
RSK-Bad signaling
event
TGF beta super family signaling pathway (through p38 cascade)
event
Grb2-Sos-Ras-PI3K signaling
event
Phosphorylation of 4EBP by TOR of TORC1 in cytosol
event
IMR:0002736
http://purl.org/obo/owl/IMR#IMR_0002736
IMR:0002730
http://purl.org/obo/owl/IMR#IMR_0002730
IMR:0002721
http://purl.org/obo/owl/IMR#IMR_0002721
IMR:0000898
http://purl.org/obo/owl/IMR#IMR_0000898
Phosphorylation of 4EBP by mTOR in cytosol
Phosphorylation of 4EBP by TOR of TOR:LST8:Raptor in cytosol
JAK STAT signaling (Angiotensin induced)
event
PubMed:16870827
http://purl.org/obo/owl/PubMed#PubMed_16870827
JAK STAT signaling pathway (Angiotensin induced)
IL1 signaling (through IKK-NF-kappaB cascade)
event
KEGG:rno04210
http://purl.org/obo/owl/KEGG#KEGG_rno04210
KEGG:mmu04210
http://purl.org/obo/owl/KEGG#KEGG_mmu04210
KEGG:hsa04210
http://purl.org/obo/owl/KEGG#KEGG_hsa04210
Organic chemical treatment
event
PLC beta signaling
event
CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
event
CD4 T cell receptor signaling pathway (through PLC gamma, PKC and IKK-NF-kappaB cascade)
Phosphorylation of S6K1 by TOR of TORC1 in cytosol
event
IMR:0002798
http://purl.org/obo/owl/IMR#IMR_0002798
Phosphorylation of S6K1 by TOR of TOR:LST8:Raptor in cytosol
IMR:0002736
http://purl.org/obo/owl/IMR#IMR_0002736
IMR:0002730
http://purl.org/obo/owl/IMR#IMR_0002730
IMR:0002721
http://purl.org/obo/owl/IMR#IMR_0002721
Activation of p70S6K by mTOR
Translocation of Notch (NIC) from plasma membrane to cytosol
event
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
Cellular event
event
Apoptosis (Inhibition of cell survival)
event
KEGG:hsa04210
http://purl.org/obo/owl/KEGG#KEGG_hsa04210
GO:0006915
http://purl.org/obo/owl/GO#GO_0006915
KEGG:rno04210
http://purl.org/obo/owl/KEGG#KEGG_rno04210
KEGG:mmu04210
http://purl.org/obo/owl/KEGG#KEGG_mmu04210
apoptotic programmed cell death
apoptotic cell death
programmed cell death by apoptosis
A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposition of phosphatidylserine.
GO:0006915
http://purl.org/obo/owl/GO#GO_0006915
Molecular event
event
Dormancy
event
The process by which a dormant state is induced, maintained and broken. Dormancy is characterized by a suspension of physiological activity.
GO:0022611
http://purl.org/obo/owl/GO#GO_0022611
GO:0022611
http://purl.org/obo/owl/GO#GO_0022611
Bud dormancy
event
Seed dormancy
event
The process by which a dormant state is induced and maintained in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated once dormancy is broken.
GO:0010162
http://purl.org/obo/owl/GO#GO_0010162
GO:0010162
http://purl.org/obo/owl/GO#GO_0010162
Disease
event
Cell proliferation
event
The multiplication or reproduction of cells, resulting in the rapid expansion of a cell population.
GO:0008283
http://purl.org/obo/owl/GO#GO_0008283
GO:0008283
http://purl.org/obo/owl/GO#GO_0008283
Cell cycle
event
The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
GO:0007049
http://purl.org/obo/owl/GO#GO_0007049
MeSH:D002453
http://purl.org/obo/owl/MeSH#MeSH_D002453
GO:0007049
http://purl.org/obo/owl/GO#GO_0007049
Cell cycle arrest
event
The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M).
GO:0007050
http://purl.org/obo/owl/GO#GO_0007050
termination of cell cycle
cessation of cell cycle
GO:0007050
http://purl.org/obo/owl/GO#GO_0007050
arrest of cell cycle progression
Cytokinesis
event
A cellular process resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components.
GO:0000910
http://purl.org/obo/owl/GO#GO_0000910
GO:0000910
http://purl.org/obo/owl/GO#GO_0000910
Transdifferentiation
event
GO:0060290
http://purl.org/obo/owl/GO#GO_0060290
The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.
GO:0060290
http://purl.org/obo/owl/GO#GO_0060290
Epithelial to mesenchymal transdifferentiation
event
Organism event
event
Development
event
GO:0032502
http://purl.org/obo/owl/GO#GO_0032502
Adipocyte differentiation
event
The process whereby a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
GO:0045444
http://purl.org/obo/owl/GO#GO_0045444
fat cell differentiation
GO:0045444
http://purl.org/obo/owl/GO#GO_0045444
adipose cell differentiation
GO:0045444
http://purl.org/obo/owl/GO#GO_0045444
adipocyte cell differentiation
GO:0045444
http://purl.org/obo/owl/GO#GO_0045444
GO:0045444
http://purl.org/obo/owl/GO#GO_0045444
Myoblast differentiation
event
The process whereby a relatively unspecialized cell acquires specialized features of a myoblast, a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
GO:0045445
http://purl.org/obo/owl/GO#GO_0045445
GO:0045445
http://purl.org/obo/owl/GO#GO_0045445
Osteoblast differentiation
event
GO:0001649
http://purl.org/obo/owl/GO#GO_0001649
Differentiation of the osteoblast; which is the mesodermal cell that gives rise to bone.
GO:0001649
http://purl.org/obo/owl/GO#GO_0001649
Inhibition of Adipocyte differentiation
event
Any process that stops, prevents or reduces the rate, frequency or extent of adipocyte differentiation.
GO:0045599
http://purl.org/obo/owl/GO#GO_0045599
GO:0045599
http://purl.org/obo/owl/GO#GO_0045599
negative regulation of fat cell differentiation
GO:0045599
http://purl.org/obo/owl/GO#GO_0045599
Negative regulation of myoblast differentiation
event
Any process that stops, prevents or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
GO:0045662
http://purl.org/obo/owl/GO#GO_0045662
GO:0045662
http://purl.org/obo/owl/GO#GO_0045662
Negative regulation of osteoblast differentiation
event
GO:0045668
http://purl.org/obo/owl/GO#GO_0045668
Any process that stops, prevents or reduces the rate, frequency or extent of osteoblast differentiation.
GO:0045668
http://purl.org/obo/owl/GO#GO_0045668
TGF beta super family signaling pathway
event
Cell growth
event
growth of cell
The process by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
GO:0016049
http://purl.org/obo/owl/GO#GO_0016049
cellular growth
GO:0016049
http://purl.org/obo/owl/GO#GO_0016049
Cytoskeleton organization
event
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
GO:0007010
http://purl.org/obo/owl/GO#GO_0007010
cytoskeleton organisation
GO:0007010
http://purl.org/obo/owl/GO#GO_0007010
Lamellipodium biogenesis
event
Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
GO:0030032
http://purl.org/obo/owl/GO#GO_0030032
GO:0030032
http://purl.org/obo/owl/GO#GO_0030032
Membrane ruffling
event
Stress fiber formation
event
Assembly of a stress fiber, the bundle of microfilaments and other proteins found in fibroblasts.
GO:0043149
http://purl.org/obo/owl/GO#GO_0043149
GO:0043149
http://purl.org/obo/owl/GO#GO_0043149
Ecodormancy
event
Cell death
event
The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
GO:0008219
http://purl.org/obo/owl/GO#GO_0008219
GO:0008219
http://purl.org/obo/owl/GO#GO_0008219
Immune response
event
GO:0006955
http://purl.org/obo/owl/GO#GO_0006955
Any process involved in the immunological reaction of an organism to an immunogenic stimulus.
GO:0006955
http://purl.org/obo/owl/GO#GO_0006955
Tumorigenesis
event
oncogenesis
Programmed cell death
event
Cell death resulting from activation of endogenous cellular processes.
GO:0012501
http://purl.org/obo/owl/GO#GO_0012501
GO:0012501
http://purl.org/obo/owl/GO#GO_0012501
M phase
event
GO:0000279
http://purl.org/obo/owl/GO#GO_0000279
A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division.
GO:0000279
http://purl.org/obo/owl/GO#GO_0000279
Cell motion
event
Any process involved in the controlled movement of a cell.
GO:0006928
http://purl.org/obo/owl/GO#GO_0006928
GO:0006928
http://purl.org/obo/owl/GO#GO_0006928
cell movement
Cell migration
event
GO:0016477
http://purl.org/obo/owl/GO#GO_0016477
The orderly movement of cells from one site to another, often during the development of a multicellular organism.
GO:0016477
http://purl.org/obo/owl/GO#GO_0016477
Cell adhesion
event
The attachment of a cell, either to another cell or to the extracellular matrix, via cell adhesion molecules.
GO:0007155
http://purl.org/obo/owl/GO#GO_0007155
KEGG:hsa04510
http://purl.org/obo/owl/KEGG#KEGG_hsa04510
GO:0007155
http://purl.org/obo/owl/GO#GO_0007155
Behavior
event
GO:0007610
http://purl.org/obo/owl/GO#GO_0007610
The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
GO:0007610
http://purl.org/obo/owl/GO#GO_0007610
B cell receptor signaling pathway
event
B-lymphocyte receptor signaling pathway
GO:0050853
http://purl.org/obo/owl/GO#GO_0050853
B lymphocyte receptor signaling pathway
GO:0050853
http://purl.org/obo/owl/GO#GO_0050853
GO:0050853
http://purl.org/obo/owl/GO#GO_0050853
A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
GO:0050853
http://purl.org/obo/owl/GO#GO_0050853
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
B-cell receptor signaling pathway
GO:0050853
http://purl.org/obo/owl/GO#GO_0050853
KEGG:hsa04662
http://purl.org/obo/owl/KEGG#KEGG_hsa04662
Toll-like receptor signaling pathway (p38 cascade)
event
Negative regulation of BAD inactivation signaling
event
Negative regulation of BAD phosphorylation signaling
IL1 signaling pathway
event
REACT:22272.1
http://purl.org/obo/owl/REACT#REACT_22272.1
Skeletal muscle hypertrophy
event
AKT(PKB)-TOR signaling
event
KEGG:hsa04150
http://purl.org/obo/owl/KEGG#KEGG_hsa04150
AKT(PKB)-mTOR signaling
mTOR signaling
TNFR1 signaling pathway (through NF-kappaB cascade)
IEV:0000119
event
TNFR2 Signaling Pathway
TNFR1 signaling pathway (through caspase cascade)
event
TNF signaling
GO:0008624
http://purl.org/obo/owl/GO#GO_0008624
KEGG:mmu04210
http://purl.org/obo/owl/KEGG#KEGG_mmu04210
KEGG:hsa04210
http://purl.org/obo/owl/KEGG#KEGG_hsa04210
REACT:1432.1
http://purl.org/obo/owl/REACT#REACT_1432.1
KEGG:rno04210
http://purl.org/obo/owl/KEGG#KEGG_rno04210
ERK cascade
event
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
ERK1/2 cascade
ERK1 and ERK2 cascade
A cascade of protein kinase activities, culminating in the phosphorylation and activation of either the ERK1 or ERK2 kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases.nNote that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2, not other ERK kinases.
GO:0070371
http://purl.org/obo/owl/GO#GO_0070371
Negative feedback regulation of Ras-Raf-MAPK signaling by Sprouty (Drosophila)
event
OBSOLETE: remap to 'Negative feedback regulation of Ras-Raf-MAPK signaling by Sprouty' IEV:0003547.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Negative feedback regulation of Ras-Raf-MAPK signaling by spred (Drosophila)
event
OBSOLETE: remap to 'Negative feedback regulation of Ras-Raf-MAPK signaling by spred' IEV:0003546.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
SUMOylation
event
Reversible reaction that create a covalent bond between a C-terminus G of an ubiquitine like sumo protein and a K residue of the target.
MI:0566
http://purl.org/obo/owl/MI#MI_0566
MI:0566
http://purl.org/obo/owl/MI#MI_0566
TPO signaling pathway
event
Rhodopsin mediated signaling pathway
event
The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon.
GO:0016056
http://purl.org/obo/owl/GO#GO_0016056
GO:0016056
http://purl.org/obo/owl/GO#GO_0016056
Proteasome mediated protein degradation signaling
event
proteasomal ubiquitin-dependent protein degradation
proteasomal ubiquitin-dependent protein catabolism
proteasomal ubiquitin-dependent protein catabolic process
GO:0043161
http://purl.org/obo/owl/GO#GO_0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
GO:0043161
http://purl.org/obo/owl/GO#GO_0043161
proteasomal pathway
proteasomal ubiquitin-dependent protein breakdown
PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
event
Integrin signaling pathway
event
Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands.
GO:0007229
http://purl.org/obo/owl/GO#GO_0007229
GO:0007229
http://purl.org/obo/owl/GO#GO_0007229
KEGG:hsa04510
http://purl.org/obo/owl/KEGG#KEGG_hsa04510
Glutamate receptor signaling pathway
event
The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor.
GO:0007215
http://purl.org/obo/owl/GO#GO_0007215
GO:0007215
http://purl.org/obo/owl/GO#GO_0007215
glutamate signaling pathway
Insulin receptor signaling pathway (through Shc mediated signaling)
event
Insulin receptor signaling pathway (through ERK cascade)
Integrin signaling pathway (through ERK cascade)
event
KEGG:hsa04510
http://purl.org/obo/owl/KEGG#KEGG_hsa04510
Caspase Cascade
event
KEGG:rno04210
http://purl.org/obo/owl/KEGG#KEGG_rno04210
KEGG:mmu04210
http://purl.org/obo/owl/KEGG#KEGG_mmu04210
KEGG:hsa04210
http://purl.org/obo/owl/KEGG#KEGG_hsa04210
Oligomerization of Bax in cytosol
event
REACT:341.2
http://purl.org/obo/owl/REACT#REACT_341.2
IMR:0000453
http://purl.org/obo/owl/IMR#IMR_0000453
Oligomerization of BAX at the mitochondrial membrane
Cyclin E degradation signaling
event
GO:0008054
http://purl.org/obo/owl/GO#GO_0008054
Phosphorylation of Bad by RSK in cytosol
event
IMR:0100288
http://purl.org/obo/owl/IMR#IMR_0100288
IMR:0000248
http://purl.org/obo/owl/IMR#IMR_0000248
Binding of SOCS and JAK in cytosol
event
IMR:0000213
http://purl.org/obo/owl/IMR#IMR_0000213
IMR:0000460
http://purl.org/obo/owl/IMR#IMR_0000460
Growth hormone signaling pathway (JAK2, STAT5)
event
IL4 signaling pathway (JAK1, JAK3, STAT6)
event
IL3 signaling pathway (JAK1, JAK2, STAT5)
event
IL2 signaling (JAK1, JAK3, STAT5)
event
IL2 signaling pathway (JAK1, JAK3, STAT5)
PubMed:8700888
http://purl.org/obo/owl/PubMed#PubMed_8700888
IL12 signaling pathway (JAK2, TYK2, STAT4)
event
PubMed:10415122
http://purl.org/obo/owl/PubMed#PubMed_10415122
IL10 signaling (JAK1, TYK2, STAT3)
event
PubMed:10433356
http://purl.org/obo/owl/PubMed#PubMed_10433356
IL10 signaling pathway (JAK1, TYK2, STAT3)
IL7 signaling (JAK1, JAK3, STAT5)
event
IL7 signaling pathway (JAK1, JAK3, STAT5)
Flower development
event
Flowering
GO:0009908
http://purl.org/obo/owl/GO#GO_0009908
The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem.
GO:0009908
http://purl.org/obo/owl/GO#GO_0009908
Growth
event
GO:0040007
http://purl.org/obo/owl/GO#GO_0040007
The increase in size or mass of an entire organism, a part of an organism or a cell.
GO:0040007
http://purl.org/obo/owl/GO#GO_0040007
Negative feedback regulation of JAK STAT pathway by (binding of SOCS and JAK)
event
IMR:0000213
http://purl.org/obo/owl/IMR#IMR_0000213
IMR:0000460
http://purl.org/obo/owl/IMR#IMR_0000460
Regulation pathway
event
Dephosphorylation of Jak by PTP in cytosol
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
IMR:0000213
http://purl.org/obo/owl/IMR#IMR_0000213
Dephosphorylation of cytokine receptor by PTP in cytosol
event
IMR:0000095
http://purl.org/obo/owl/IMR#IMR_0000095
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Negative regulation of transcription by PIAS
event
IMR:0002914
http://purl.org/obo/owl/IMR#IMR_0002914
PubMed:15021887
http://purl.org/obo/owl/PubMed#PubMed_15021887
Dephosphorylation of STAT dimer by PTP in cytosol
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
Negative regulation of JAK STAT pathway
event
GO:0046426
http://purl.org/obo/owl/GO#GO_0046426
Any process that stops, prevents or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity.
GO:0046426
http://purl.org/obo/owl/GO#GO_0046426
Negative feedback regulation of JAK STAT pathway by (binding of SOCS and cytokine receptor)
event
IMR:0000095
http://purl.org/obo/owl/IMR#IMR_0000095
IMR:0000460
http://purl.org/obo/owl/IMR#IMR_0000460
Binding of SOCS and Cytokine receptor in cytosol
event
IMR:0000095
http://purl.org/obo/owl/IMR#IMR_0000095
IMR:0000460
http://purl.org/obo/owl/IMR#IMR_0000460
Cell survival (Inhibition of apoptosis)
event
Binding of TGF beta superfamily and TGF beta superfamily receptor I/II in extracellular
event
IMR:0000036
http://purl.org/obo/owl/IMR#IMR_0000036
IMR:0000092
http://purl.org/obo/owl/IMR#IMR_0000092
Transcription by R-Smad:Smad4 in nucleus
event
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
Binding of R-Smad:Smad4 complex, Coactivator and responsive element in inner space of nucleus
event
IMR:0000424
http://purl.org/obo/owl/IMR#IMR_0000424
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
IGS:0000028
http://purl.org/obo/owl/IGS#IGS_0000028
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
Phosphorylation of R-Smad by TGF beta receptor I in cytosol
event
IMR:0000710
http://purl.org/obo/owl/IMR#IMR_0000710
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
GO:0007182
http://purl.org/obo/owl/GO#GO_0007182
Nuclear import of R-Smad:Smad4
event
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
GO:0007184
http://purl.org/obo/owl/GO#GO_0007184
Complex formation of R-Smad and Smad4 in cytosol
event
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
GO:0007183
http://purl.org/obo/owl/GO#GO_0007183
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
Phosphorylation of TGF-b receptor I by TGF beta receptor II in cytosol
event
IMR:0000712
http://purl.org/obo/owl/IMR#IMR_0000712
IMR:0000710
http://purl.org/obo/owl/IMR#IMR_0000710
Fas signaling pathway (through caspase cascade)
event
FasL/ CD95L signaling
GO:0008624
http://purl.org/obo/owl/GO#GO_0008624
REACT:900.1
http://purl.org/obo/owl/REACT#REACT_900.1
Estrogen receptor signaling pathway
event
GO:0030520
http://purl.org/obo/owl/GO#GO_0030520
Any series of molecular signals generated as a consequence of an estrogen binding to its receptor.
GO:0030520
http://purl.org/obo/owl/GO#GO_0030520
fMLP signaling pathway
event
Notch signaling pathway
event
The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell.
GO:0007219
http://purl.org/obo/owl/GO#GO_0007219
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
N signaling pathway
GO:0007219
http://purl.org/obo/owl/GO#GO_0007219
KEGG:hsa04330
http://purl.org/obo/owl/KEGG#KEGG_hsa04330
GO:0007219
http://purl.org/obo/owl/GO#GO_0007219
p53 signaling pathway (through p21)
event
AKT(PKB)-Bad signaling
event
PI3K-AKT(PKB)-Bad signaling
KEGG:mmu04210
http://purl.org/obo/owl/KEGG#KEGG_mmu04210
KEGG:rno04210
http://purl.org/obo/owl/KEGG#KEGG_rno04210
KEGG:hsa04210
http://purl.org/obo/owl/KEGG#KEGG_hsa04210
Bax activation signaling
event
Activation, translocation and oligomerization of BAX
Bax dimerization signaling
KEGG:hsa04210
http://purl.org/obo/owl/KEGG#KEGG_hsa04210
GO:0008633
http://purl.org/obo/owl/GO#GO_0008633
KEGG:rno04210
http://purl.org/obo/owl/KEGG#KEGG_rno04210
KEGG:mmu04210
http://purl.org/obo/owl/KEGG#KEGG_mmu04210
REACT:584.3
http://purl.org/obo/owl/REACT#REACT_584.3
Endodormancy
event
Oxidation in unidentified cellular location
event
Binding of Bad and Bcl-2/Bcl-xL in mitochondria membrane
event
BAD displaces tBID from BCL-2 sequestration
IMR:0100288
http://purl.org/obo/owl/IMR#IMR_0100288
IMR:0100293
http://purl.org/obo/owl/IMR#IMR_0100293
IMR:0100261
http://purl.org/obo/owl/IMR#IMR_0100261
REACT:1062.2
http://purl.org/obo/owl/REACT#REACT_1062.2
Oxidation in cytosol
event
Paradormancy
event
Negative regulation of Fas signaling pathway
event
Binding outside the mitochondria membrane
event
Translocation from mitochondria membrane to cytosol
event
Permeabilization of mitochondria and Translocation of Cyt c from mitochondria to cytosol
event
Release of Cytochrome c from mitochondria
REACT:535.3
http://purl.org/obo/owl/REACT#REACT_535.3
IMR:0001206
http://purl.org/obo/owl/IMR#IMR_0001206
Negative regulation of Caspase cascade (through mitochondria)
event
Binding of Cyt c and Apaf1 in cytosol
event
REACT:1640.2
http://purl.org/obo/owl/REACT#REACT_1640.2
Cytochrome C Binds to Apaf-1
IMR:0001206
http://purl.org/obo/owl/IMR#IMR_0001206
IMR:0001204
http://purl.org/obo/owl/IMR#IMR_0001204
Binding of Cyt c and Bcl-2/Bcl-xL
event
IMR:0100293
http://purl.org/obo/owl/IMR#IMR_0100293
IMR:0100261
http://purl.org/obo/owl/IMR#IMR_0100261
Phosphorylation of Bcl-2 in cytosol
event
IMR:0100261
http://purl.org/obo/owl/IMR#IMR_0100261
Internalization of TGF beta receptor
event
IMR:0000092
http://purl.org/obo/owl/IMR#IMR_0000092
Gene expression
event
GO:0010467
http://purl.org/obo/owl/GO#GO_0010467
The process by which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
GO:0010467
http://purl.org/obo/owl/GO#GO_0010467
Transcription
event
The synthesis of either RNA on a template of DNA or DNA on a template of RNA.
GO:0006350
http://purl.org/obo/owl/GO#GO_0006350
GO:0006350
http://purl.org/obo/owl/GO#GO_0006350
Hydrolysis
event
lyase activity
EC:3.-.-.-
http://purl.org/obo/owl/EC#EC_3.-.-.-
GO:0016787
http://purl.org/obo/owl/GO#GO_0016787
EC:3 catalyzed process
EC:3.-.-.-
http://purl.org/obo/owl/EC#EC_3.-.-.-
Environmental event
event
Binding in unidentified cellular location
event
Phosphorylation in unidentified cellular location
event
Negative regulation of NF-kappaB signaling (cytoplasmic sequestering)
event
Binding of NF-kappaB and specific modules in cytosol
event
IMR:0000382
http://purl.org/obo/owl/IMR#IMR_0000382
Induction of (Para) dormancy
event
Binding of IL1 and IL1R complex in extracellular
event
IMR:0000120
http://purl.org/obo/owl/IMR#IMR_0000120
IMR:0000011
http://purl.org/obo/owl/IMR#IMR_0000011
GO:0004908
http://purl.org/obo/owl/GO#GO_0004908
Binding of MyD88 and IRAK1 in cytosol
event
IMR:0100465
http://purl.org/obo/owl/IMR#IMR_0100465
IMR:0000890
http://purl.org/obo/owl/IMR#IMR_0000890
Binding of IL-1R complex and Tollip in cytosol
event
IMR:0000120
http://purl.org/obo/owl/IMR#IMR_0000120
IMR:0000894
http://purl.org/obo/owl/IMR#IMR_0000894
Binding of MyD88 and IRAK4 in cytosol
event
IMR:0100465
http://purl.org/obo/owl/IMR#IMR_0100465
IMR:0000892
http://purl.org/obo/owl/IMR#IMR_0000892
Binding of IL1-R complex and MyD88 in cytosol
event
IMR:0100465
http://purl.org/obo/owl/IMR#IMR_0100465
IMR:0000120
http://purl.org/obo/owl/IMR#IMR_0000120
Binding of Tollip and IRAK1 in cytosol
event
IMR:0000890
http://purl.org/obo/owl/IMR#IMR_0000890
IMR:0000894
http://purl.org/obo/owl/IMR#IMR_0000894
Phosphorylation of IRAK1 by IRAK4 in cytosol
event
IMR:0000892
http://purl.org/obo/owl/IMR#IMR_0000892
IMR:0000890
http://purl.org/obo/owl/IMR#IMR_0000890
Phosphorylation in plasma membrane
event
GDP-GTP exchange in plasma membrane
event
Binding of IRAK1_p and TRAF6 in cytosol
event
IMR:0000890
http://purl.org/obo/owl/IMR#IMR_0000890
IMR:0100427
http://purl.org/obo/owl/IMR#IMR_0100427
Binding of IRAK1:TRAF6 and TAK1:TAB1:TAB2 in cytosol
event
IMR:0100427
http://purl.org/obo/owl/IMR#IMR_0100427
IMR:0000893
http://purl.org/obo/owl/IMR#IMR_0000893
IMR:0000890
http://purl.org/obo/owl/IMR#IMR_0000890
IMR:0000441
http://purl.org/obo/owl/IMR#IMR_0000441
IMR:0000232
http://purl.org/obo/owl/IMR#IMR_0000232
Ubiquitination of TRAF6 in cytosol
event
IMR:0100427
http://purl.org/obo/owl/IMR#IMR_0100427
Lyase process in cytosol
event
Ubiquitination in unidentified cellular location
event
Ubiquitination of IRAK1_p in cytosol
event
IMR:0000890
http://purl.org/obo/owl/IMR#IMR_0000890
Proteasome degradation in plasma membrane
event
Proteasome degradation of IRAK1_p in cytosol
event
IMR:0000890
http://purl.org/obo/owl/IMR#IMR_0000890
IKK-NF-kappaB cascade
event
A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase.
GO:0007249
http://purl.org/obo/owl/GO#GO_0007249
NIK-I-kappaB/NF-kappaB cascade
GO:0007249
http://purl.org/obo/owl/GO#GO_0007249
I-kappaB kinase/NF-kappaB cascade
GO:0007249
http://purl.org/obo/owl/GO#GO_0007249
KEGG:hsa04210
http://purl.org/obo/owl/KEGG#KEGG_hsa04210
KEGG:mmu04210
http://purl.org/obo/owl/KEGG#KEGG_mmu04210
PubMed:15134788
http://purl.org/obo/owl/PubMed#PubMed_15134788
GO:0007249
http://purl.org/obo/owl/GO#GO_0007249
KEGG:rno04210
http://purl.org/obo/owl/KEGG#KEGG_rno04210
Phosphorylation of NIK by TAK1 in cytosol
event
IMR:0000242
http://purl.org/obo/owl/IMR#IMR_0000242
IMR:0000232
http://purl.org/obo/owl/IMR#IMR_0000232
Proteasome degradation of I-kappaB in cytosol
IEV:0001265
event
IMR:0000464
http://purl.org/obo/owl/IMR#IMR_0000464
PubMed:15134788
http://purl.org/obo/owl/PubMed#PubMed_15134788
Proteasome degradation of I-kappaB by 26S proteasome in cytosol
Release of (eco) dormancy
event
Ubiquitination of I-kappaB_p in cytosol
event
IEV:0001266
IMR:0000464
http://purl.org/obo/owl/IMR#IMR_0000464
PubMed:15134788
http://purl.org/obo/owl/PubMed#PubMed_15134788
Ubiquitination of I-kappaB in cytosol
Phosphorylation of I-kappaB_p by IKK complex_p in cytosol
event
GO:0007252
http://purl.org/obo/owl/GO#GO_0007252
PubMed:15134788
http://purl.org/obo/owl/PubMed#PubMed_15134788
IMR:0000243
http://purl.org/obo/owl/IMR#IMR_0000243
Phosphorylation of I-kappaB_p by IKK complex_p [mammals]
IMR:0000464
http://purl.org/obo/owl/IMR#IMR_0000464
Binding of NF-kappaB and I-kappaB in cytosol
event
GO:0007253
http://purl.org/obo/owl/GO#GO_0007253
IMR:0000464
http://purl.org/obo/owl/IMR#IMR_0000464
PubMed:15134788
http://purl.org/obo/owl/PubMed#PubMed_15134788
IMR:0000382
http://purl.org/obo/owl/IMR#IMR_0000382
Dissociation of NF-kappaB and I-kappaB in cytosol
event
GO:0008588
http://purl.org/obo/owl/GO#GO_0008588
IMR:0000464
http://purl.org/obo/owl/IMR#IMR_0000464
IMR:0000382
http://purl.org/obo/owl/IMR#IMR_0000382
PubMed:15134788
http://purl.org/obo/owl/PubMed#PubMed_15134788
Dissociation of NF-kappaB and I-kappaB [mammals]
Nuclear import of NF-kappaB
event
GO:0042348
http://purl.org/obo/owl/GO#GO_0042348
IMR:0000382
http://purl.org/obo/owl/IMR#IMR_0000382
PubMed:15134788
http://purl.org/obo/owl/PubMed#PubMed_15134788
NF-kappaB protein-nucleus import
NF-kappaB import into nucleus
NF-kappaB-nucleus import
NF-kappaB transport from cytoplasm to nucleus
The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
GO:0042348
http://purl.org/obo/owl/GO#GO_0042348
Binding of NF-kappaB and responsive element in inner space of nucleus
event
PubMed:11973130
http://purl.org/obo/owl/PubMed#PubMed_11973130
IMR:0000382
http://purl.org/obo/owl/IMR#IMR_0000382
IGS:0000028
http://purl.org/obo/owl/IGS#IGS_0000028
Gene expression of cytokine by NF-kappaB
event
IMR:0000006
http://purl.org/obo/owl/IMR#IMR_0000006
IMR:0000382
http://purl.org/obo/owl/IMR#IMR_0000382
Translation
event
GO:0006412
http://purl.org/obo/owl/GO#GO_0006412
The chemical reactions and pathways resulting in the formation of a protein. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
GO:0006412
http://purl.org/obo/owl/GO#GO_0006412
Metabolic reaction
event
Myristoylation
event
Reaction that can affect K or G residues.
MI:0214
http://purl.org/obo/owl/MI#MI_0214
MI:0214
http://purl.org/obo/owl/MI#MI_0214
GDP-GTP exchange
event
GDP+ phosphate = GTP + H2O
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
IL-1 signaling (through JNK cascade)
event
IL1 signaling pathway (through JNK cascade)
Gene expression of cytokine by AP-1
event
IMR:0000006
http://purl.org/obo/owl/IMR#IMR_0000006
IMR:0000414
http://purl.org/obo/owl/IMR#IMR_0000414
JNK cascade
event
GO:0007254
http://purl.org/obo/owl/GO#GO_0007254
A cascade of protein kinase activities, culminating in the phosphorylation and activation of a JUN kinase, a member of a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
GO:0007254
http://purl.org/obo/owl/GO#GO_0007254
Phosphorylation of MKK4/7 by MAPKKK in cytosol
event
activation of JNKK activity
GO:0007256
http://purl.org/obo/owl/GO#GO_0007256
IMR:0000229
http://purl.org/obo/owl/IMR#IMR_0000229
IMR:0000262
http://purl.org/obo/owl/IMR#IMR_0000262
GO:0007256
http://purl.org/obo/owl/GO#GO_0007256
The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity in response to phosphorylation by a member of the JUN kinase kinase kinase (JNKKK) family, or another upstream kinase. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress.
GO:0007256
http://purl.org/obo/owl/GO#GO_0007256
Phosphorylation of JNK by MKK4/7_p in cytosol
event
IMR:0000225
http://purl.org/obo/owl/IMR#IMR_0000225
IMR:0000262
http://purl.org/obo/owl/IMR#IMR_0000262
GO:0007257
http://purl.org/obo/owl/GO#GO_0007257
Nuclear import of JNK_p
event
IMR:0000225
http://purl.org/obo/owl/IMR#IMR_0000225
Phosphorylation of c-Jun by JNK_p in inner space of nucleus
event
The process of introducing a phosphoric group into a JUN protein.
GO:0007258
http://purl.org/obo/owl/GO#GO_0007258
IMR:0000817
http://purl.org/obo/owl/IMR#IMR_0000817
GO:0007258
http://purl.org/obo/owl/GO#GO_0007258
IMR:0000225
http://purl.org/obo/owl/IMR#IMR_0000225
Phosphorylation in nucleus
event
IL-1 signaling (through p38 cascade)
event
IL1 signaling pathway (through p38 cascade)
Gene expression by transcriptional regulator
event
IMR:0000369
http://purl.org/obo/owl/IMR#IMR_0000369
p38 cascade
event
Phosphorylation of p38 by MKK3/6_p in cytosol
event
IMR:0000263
http://purl.org/obo/owl/IMR#IMR_0000263
IMR:0000226
http://purl.org/obo/owl/IMR#IMR_0000226
Phosphorylation of MKK3/4/6 by MAPKKK in cytosol
event
IMR:0100454
http://purl.org/obo/owl/IMR#IMR_0100454
IMR:0000263
http://purl.org/obo/owl/IMR#IMR_0000263
IMR:0000229
http://purl.org/obo/owl/IMR#IMR_0000229
Nuclear import of p38_p
event
IMR:0000226
http://purl.org/obo/owl/IMR#IMR_0000226
Phosphorylation of transcriptional regulator by p38_p in inner space of nucleus
event
IMR:0000369
http://purl.org/obo/owl/IMR#IMR_0000369
IMR:0000226
http://purl.org/obo/owl/IMR#IMR_0000226
Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
event
Binding of LPS and TLR4:MD-2:CD14 in extracellular
event
IMR:0001439
http://purl.org/obo/owl/IMR#IMR_0001439
IMR:0001440
http://purl.org/obo/owl/IMR#IMR_0001440
IMR:0001655
http://purl.org/obo/owl/IMR#IMR_0001655
IMR:0001438
http://purl.org/obo/owl/IMR#IMR_0001438
Binding of TLR4:MD-2:CD14 and MyD88 in cytosol
event
IMR:0100465
http://purl.org/obo/owl/IMR#IMR_0100465
IMR:0001440
http://purl.org/obo/owl/IMR#IMR_0001440
IMR:0001439
http://purl.org/obo/owl/IMR#IMR_0001439
IMR:0001438
http://purl.org/obo/owl/IMR#IMR_0001438
Binding of MyD88 and IRAK in cytosol
event
IMR:0100488
http://purl.org/obo/owl/IMR#IMR_0100488
IMR:0100465
http://purl.org/obo/owl/IMR#IMR_0100465
Activation of IRAK in cytosol
event
IMR:0100488
http://purl.org/obo/owl/IMR#IMR_0100488
Activation in plasma membrane
event
Inactivation in extracellular
event
Inactivation in unidentified cellular location
event
Binding of activated IRAK and TRAF6 in cytosol
event
IMR:0100427
http://purl.org/obo/owl/IMR#IMR_0100427
IMR:0100488
http://purl.org/obo/owl/IMR#IMR_0100488
Binding of TRAF6 and TAB1:TAB2:TAK1 in cytosol
event
IMR:0000232
http://purl.org/obo/owl/IMR#IMR_0000232
IMR:0000441
http://purl.org/obo/owl/IMR#IMR_0000441
IMR:0000893
http://purl.org/obo/owl/IMR#IMR_0000893
IMR:0100427
http://purl.org/obo/owl/IMR#IMR_0100427
Reduction in cytosol
event
Phosphorylation of IKK complex by MAPKKK in cytosol
event
GO:0007250
http://purl.org/obo/owl/GO#GO_0007250
IMR:0000229
http://purl.org/obo/owl/IMR#IMR_0000229
IMR:0000243
http://purl.org/obo/owl/IMR#IMR_0000243
Binding of TNF alpha homotrimer and TNFR1 in extracellular
event
TNF Binds TNF-R1
IMR:0000025
http://purl.org/obo/owl/IMR#IMR_0000025
REACT:2096.2
http://purl.org/obo/owl/REACT#REACT_2096.2
IMR:0000060
http://purl.org/obo/owl/IMR#IMR_0000060
Trimerization of TNFR1 in plasma membrane
event
IMR:0000060
http://purl.org/obo/owl/IMR#IMR_0000060
TNFR1 trimerization
Binding of TNFR1 trimer and TRADD in cytosol
event
IMR:0000060
http://purl.org/obo/owl/IMR#IMR_0000060
IMR:0100464
http://purl.org/obo/owl/IMR#IMR_0100464
Binding of TRADD and TRAF2 in cytosol
event
IMR:0100423
http://purl.org/obo/owl/IMR#IMR_0100423
IMR:0100464
http://purl.org/obo/owl/IMR#IMR_0100464
Activation of RIP by TRAF2 in cytosol
event
IMR:0100423
http://purl.org/obo/owl/IMR#IMR_0100423
IMR:0000269
http://purl.org/obo/owl/IMR#IMR_0000269
Activation of MEKK3 by RIP in cytosol
event
IMR:0100451
http://purl.org/obo/owl/IMR#IMR_0100451
IMR:0000269
http://purl.org/obo/owl/IMR#IMR_0000269
Complex formation of TCR-CD3 in plasma membrane
event
PubMed:15343367
http://purl.org/obo/owl/PubMed#PubMed_15343367
IMR:0002372
http://purl.org/obo/owl/IMR#IMR_0002372
TCR-CD3 complex formation
Binding of antigen, TCR-CD3 complex and CD4 in extracellular
event
IMR:0100294
http://purl.org/obo/owl/IMR#IMR_0100294
IMR:0000465
http://purl.org/obo/owl/IMR#IMR_0000465
IMR:0002372
http://purl.org/obo/owl/IMR#IMR_0002372
PubMed:15343367
http://purl.org/obo/owl/PubMed#PubMed_15343367
Binding of TCR-CD3 complex and Lck in cytosol
event
IMR:0002372
http://purl.org/obo/owl/IMR#IMR_0002372
IMR:0100353
http://purl.org/obo/owl/IMR#IMR_0100353
Binding of TCR-CD3 complex and Fyn in cytosol
event
IMR:0100352
http://purl.org/obo/owl/IMR#IMR_0100352
IMR:0002372
http://purl.org/obo/owl/IMR#IMR_0002372
Phosphorylation of LAT by ZAP-70_p in cytosol
event
IMR:0000221
http://purl.org/obo/owl/IMR#IMR_0000221
PubMed:15343367
http://purl.org/obo/owl/PubMed#PubMed_15343367
IMR:0000348
http://purl.org/obo/owl/IMR#IMR_0000348
Phosphorylation of Vav by non-receptor tyrosine kinase in cytosol
event
IMR:0000682
http://purl.org/obo/owl/IMR#IMR_0000682
IMR:0000434
http://purl.org/obo/owl/IMR#IMR_0000434
Phosphorylation of Vav by PI3K in cytosol
event
IMR:0000434
http://purl.org/obo/owl/IMR#IMR_0000434
IMR:0000265
http://purl.org/obo/owl/IMR#IMR_0000265
Phosphorylation of ZAP-70 by Lck_p in cytosol
event
IMR:0100353
http://purl.org/obo/owl/IMR#IMR_0100353
IMR:0000221
http://purl.org/obo/owl/IMR#IMR_0000221
PubMed:12040176
http://purl.org/obo/owl/PubMed#PubMed_12040176
Phosphorylation of ZAP-70 by autophosphorylated Lck in cytosol
Binding of LAT_p and PLC gamma in cytosol
event
IMR:0000348
http://purl.org/obo/owl/IMR#IMR_0000348
IMR:0000285
http://purl.org/obo/owl/IMR#IMR_0000285
Hydrolysis of PIP2 by PLC gamma to generate DAG and IP3 in cytosol
event
IMR:0000285
http://purl.org/obo/owl/IMR#IMR_0000285
IMR:0100028
http://purl.org/obo/owl/IMR#IMR_0100028
IMR:0100027
http://purl.org/obo/owl/IMR#IMR_0100027
IMR:0001350
http://purl.org/obo/owl/IMR#IMR_0001350
Hydrolysis in plasma membrane
event
Binding of DAG and PKC and active conformational change of PKC in cytosol
event
IMR:0000245
http://purl.org/obo/owl/IMR#IMR_0000245
IMR:0100027
http://purl.org/obo/owl/IMR#IMR_0100027
PubMed:7499357
http://purl.org/obo/owl/PubMed#PubMed_7499357
Binding of IP3 and IP3R and IP3R opening
event
IMR:0100028
http://purl.org/obo/owl/IMR#IMR_0100028
IMR:0000084
http://purl.org/obo/owl/IMR#IMR_0000084
Binding in ER membrane
event
Calcium ion transport from ER to cytosol through calcium ion channel
event
IMR:0100031
http://purl.org/obo/owl/IMR#IMR_0100031
IMR:0000499
http://purl.org/obo/owl/IMR#IMR_0000499
Heterotrimeric GPCR signaling pathway (through PACAP, G alpha s and adenylate cyclase, cAMP and PKA)
event
Trimerization of MALT1:CARMA1:BCL10 in cytosol
event
IMR:0002662
http://purl.org/obo/owl/IMR#IMR_0002662
PubMed:11973130
http://purl.org/obo/owl/PubMed#PubMed_11973130
IMR:0002655
http://purl.org/obo/owl/IMR#IMR_0002655
IMR:0002658
http://purl.org/obo/owl/IMR#IMR_0002658
Binding of CD28 and CD80/CD86 in extracellular
event
IMR:0002950
http://purl.org/obo/owl/IMR#IMR_0002950
IMR:0000473
http://purl.org/obo/owl/IMR#IMR_0000473
ISBN:081533642X
http://purl.org/obo/owl/ISBN#ISBN_081533642X
PubMed:15343367
http://purl.org/obo/owl/PubMed#PubMed_15343367
Reduction in unidentified cellular location
event
CD4 T cell receptor signaling (through Ras and ERK cascade)
event
CD4 T cell receptor signaling pathway (through Ras and ERK cascade)
CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)
event
CD4 T cell receptor signaling pathway (through Vav, Rac and JNK cascade)
Activation of TAK1 in cytosol
event
IMR:0000232
http://purl.org/obo/owl/IMR#IMR_0000232
Binding of RTK and PLC gamma in cytosol
event
IMR:0000063
http://purl.org/obo/owl/IMR#IMR_0000063
IMR:0000285
http://purl.org/obo/owl/IMR#IMR_0000285
Binding of PLC and PIP3 in cytosol
event
IMR:0000284
http://purl.org/obo/owl/IMR#IMR_0000284
IMR:0001352
http://purl.org/obo/owl/IMR#IMR_0001352
Phosphorylation of PLC gamma by non-receptor tyrosine kinase in cytosol
IEV:0000285
event
PubMed:14993283
http://purl.org/obo/owl/PubMed#PubMed_14993283
IMR:0000682
http://purl.org/obo/owl/IMR#IMR_0000682
IMR:0000285
http://purl.org/obo/owl/IMR#IMR_0000285
Phosphorylation of PLC gamma by syk
Negative regulation of PLC gamma signaling (through LAT)
event
Phosphorylation of PIP2 by PI3K in plasma membrane
event
IMR:0001350
http://purl.org/obo/owl/IMR#IMR_0001350
IMR:0000265
http://purl.org/obo/owl/IMR#IMR_0000265
Binding of LAT_p and Gads in cytosol
event
IMR:0000741
http://purl.org/obo/owl/IMR#IMR_0000741
PubMed:15343367
http://purl.org/obo/owl/PubMed#PubMed_15343367
IMR:0000348
http://purl.org/obo/owl/IMR#IMR_0000348
Activation of IKK complex by PKC theta in cytosol
event
NF-kappaB activation
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
PubMed:11120819
http://purl.org/obo/owl/PubMed#PubMed_11120819
IMR:0100484
http://purl.org/obo/owl/IMR#IMR_0100484
The Physical Association of Protein Kinase Ctheta with a Lipid Raft-Associated Inhibitor of kB Factor Kinase (IKK) Complex Plays a Role in the Activation of the NF-kB Cascade by TCR and CD28.
PubMed:11120819
http://purl.org/obo/owl/PubMed#PubMed_11120819
IMR:0000243
http://purl.org/obo/owl/IMR#IMR_0000243
Activation of NF-kappaB by PKC
PubMed:11973130
http://purl.org/obo/owl/PubMed#PubMed_11973130
Medication
event
Medium condition
event
Plant hormone medication
event
KBM (medium)
event
KBM-2 (medium)
event
MEGM (medium)
event
MEBM (medium)
event
BEBM (medium)
event
SABM (medium)
event
PrEGM (medium)
event
PrEBM (medium)
event
DMEM (medium)
event
199 medium
event
Animal cell medium
event
KGM-2 (medium)
event
Rat cell medium
event
Mouse cell medium
event
Neuronal cell medium
event
ES cell medium
event
HeLa medium
event
BME medium
event
Mouse L-cell medium
event
Hepatocyte medium
event
Epidermal keratinocyto medium
event
Macrophage medium
event
Amniocyte medium
event
Peripheral blood medium
event
Bone marrow medium
event
Human hematopoietic cell medium
event
Lymphocyte medium
event
CHO medium
event
DG44 medium
event
293 medium
event
COS-7 medium
event
MDCK medium
event
VERO medium
event
BHK-21 medium
event
PK-15 medium
event
CV-1 medium
event
WI-38 medium
event
Hybridoma cell medium
event
HEp2 medium
event
A549 medium
event
BSC-1 medium
event
Ham's F-10 medium
event
Myeloma medium
event
Ham's F-12 medium
event
IMDM (medium)
event
Chicken aortic smooth muscle cell medium
event
Fibroblast medium
event
All-purpose medium
event
MEM (medium)
event
Alpha MEM (medium)
event
Jurkat cell medium
event
HL60 medium
event
Waymouth's medium
event
Mesenchymal cell medium
event
Human bronchial epithelial cell medium
event
Mammary epithelial cell medium
event
Human prostate epithelial cell medium
event
SAGM (medium)
event
BEGM (medium)
event
KGM (medium)
event
Human vascular smooth muscle medium
event
Human vascular endothelial cell medium
event
Cambium dormancy
event
Cell cycle process
event
KEGG:hsa04110
http://purl.org/obo/owl/KEGG#KEGG_hsa04110
A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
GO:0022402
http://purl.org/obo/owl/GO#GO_0022402
GO:0022402
http://purl.org/obo/owl/GO#GO_0022402
G2-M-phase transition
event
KEGG:hsa04110
http://purl.org/obo/owl/KEGG#KEGG_hsa04110
GO:0000086
http://purl.org/obo/owl/GO#GO_0000086
Progression from G2 phase to M phase of the mitotic cell cycle.
GO:0000086
http://purl.org/obo/owl/GO#GO_0000086
Binding of Cdk4 and cyclin D in cytosol
event
IMR:0100614
http://purl.org/obo/owl/IMR#IMR_0100614
IMR:0100600
http://purl.org/obo/owl/IMR#IMR_0100600
Phosphorylation of Cdk4/6 by CAK in cytosol
event
REACT:96.4
http://purl.org/obo/owl/REACT#REACT_96.4
IMR:0100636
http://purl.org/obo/owl/IMR#IMR_0100636
IMR:0100602
http://purl.org/obo/owl/IMR#IMR_0100602
IMR:0100600
http://purl.org/obo/owl/IMR#IMR_0100600
Temperature treatment
event
Radiation treatment
event
Wavelength of light treatment
event
Photoperiod treatment
event
Freeze treatment
event
Cold temperature treatment
event
High temperature treatment
event
Low temperature treatment
event
Heat treatment
event
Physical stimulus treatment
event
Gravity treatment
event
Oxidation
event
Contact pressure treatment
event
Magnetic force treatment
event
Electricity treatment
event
FK506 medication
event
Treatment
event
Nuclear import of Cdk4:cyclin D
event
IMR:0100600
http://purl.org/obo/owl/IMR#IMR_0100600
IMR:0100614
http://purl.org/obo/owl/IMR#IMR_0100614
Phosphorylation of RB by Cdk4_p in inner space of nucleus
event
IMR:0100600
http://purl.org/obo/owl/IMR#IMR_0100600
IMR:0000461
http://purl.org/obo/owl/IMR#IMR_0000461
Dissociation of E2F and RB_p in inner space of nucleus
event
REACT:1882.4
http://purl.org/obo/owl/REACT#REACT_1882.4
IMR:0000848
http://purl.org/obo/owl/IMR#IMR_0000848
IMR:0000461
http://purl.org/obo/owl/IMR#IMR_0000461
Negative regulation of G1-S-phase transition
event
Ubiquitination of Cyclin D in cytosol
event
IMR:0100614
http://purl.org/obo/owl/IMR#IMR_0100614
REACT:715.2
http://purl.org/obo/owl/REACT#REACT_715.2
DNA replication
event
The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.
GO:0006260
http://purl.org/obo/owl/GO#GO_0006260
GO:0006260
http://purl.org/obo/owl/GO#GO_0006260
MeSH:D004261
http://purl.org/obo/owl/MeSH#MeSH_D004261
REACT:383.2
http://purl.org/obo/owl/REACT#REACT_383.2
CoA ligation
event
EC:6.2.1
http://purl.org/obo/owl/EC#EC_6.2.1
Lignin biosynthesis
event
lignin formation
The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers.
GO:0009809
http://purl.org/obo/owl/GO#GO_0009809
lignin synthesis
lignin biosynthetic process
lignin anabolism
GO:0009809
http://purl.org/obo/owl/GO#GO_0009809
Embryonic development
event
The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
GO:0009790
http://purl.org/obo/owl/GO#GO_0009790
embryonal development
GO:0009790
http://purl.org/obo/owl/GO#GO_0009790
embryogenesis
Post embryonic development
event
The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
GO:0009791
http://purl.org/obo/owl/GO#GO_0009791
GO:0009791
http://purl.org/obo/owl/GO#GO_0009791
Binding of c-AMP and PKA regulatory subunits and active conformational change in cytosol
event
IEV:0000781
Dissociation of PKA catalytic subunit and regulatory subunit
IMR:0100024
http://purl.org/obo/owl/IMR#IMR_0100024
IMR:0100702
http://purl.org/obo/owl/IMR#IMR_0100702
PubMed:15023366
http://purl.org/obo/owl/PubMed#PubMed_15023366
Phosphorylation of Bad by PKA in cytosol
event
IMR:0000249
http://purl.org/obo/owl/IMR#IMR_0000249
IMR:0100288
http://purl.org/obo/owl/IMR#IMR_0100288
Phosphorylation of caspase9 by AKT in cytosol
event
IMR:0100299
http://purl.org/obo/owl/IMR#IMR_0100299
IMR:0000250
http://purl.org/obo/owl/IMR#IMR_0000250
Phosphorylation of Bad by AKT_p
event
REACT:188.2
http://purl.org/obo/owl/REACT#REACT_188.2
IMR:0100288
http://purl.org/obo/owl/IMR#IMR_0100288
IMR:0000250
http://purl.org/obo/owl/IMR#IMR_0000250
Akt1 phosphorylates BAD protein
Binding of Bad_p and 14-3-3 in cytosol
event
Sequesteration of BAD protein by 14-3-3
IMR:0000456
http://purl.org/obo/owl/IMR#IMR_0000456
IMR:0100288
http://purl.org/obo/owl/IMR#IMR_0100288
REACT:1139.2
http://purl.org/obo/owl/REACT#REACT_1139.2
Translocation of Bad_p from mitochondria membrane to cytosol
event
IMR:0100288
http://purl.org/obo/owl/IMR#IMR_0100288
Bad activation signaling
event
KEGG:hsa04210
http://purl.org/obo/owl/KEGG#KEGG_hsa04210
KEGG:mmu04210
http://purl.org/obo/owl/KEGG#KEGG_mmu04210
GO:0008633
http://purl.org/obo/owl/GO#GO_0008633
KEGG:rno04210
http://purl.org/obo/owl/KEGG#KEGG_rno04210
REACT:549.2
http://purl.org/obo/owl/REACT#REACT_549.2
Bad dephosphorylation signaling
Activation of BAD and translocation to mitochondria
Oxidation of ferulate in cytosol
event
KEGG:C01494
http://purl.org/obo/owl/KEGG#KEGG_C01494
Phosphorylation of AKT by PDK1
event
IMR:0000250
http://purl.org/obo/owl/IMR#IMR_0000250
IMR:0000255
http://purl.org/obo/owl/IMR#IMR_0000255
Removement of survival factor
event
Translocation of Bad from the cytosol to the mitochondria membrane
event
Translocation of activated BAD protein to mitochondria
GO:0001844
http://purl.org/obo/owl/GO#GO_0001844
REACT:2046.3
http://purl.org/obo/owl/REACT#REACT_2046.3
IMR:0100288
http://purl.org/obo/owl/IMR#IMR_0100288
Translocation from cytosol to mitochondria membrane
event
Dephosphorylation of Bad_p by calcineurin in cytosol
event
IMR:0000278
http://purl.org/obo/owl/IMR#IMR_0000278
REACT:1663.2
http://purl.org/obo/owl/REACT#REACT_1663.2
IMR:0100288
http://purl.org/obo/owl/IMR#IMR_0100288
Activation of BAD by calcineurin
Dephosphorylation in plasma membrane
event
Oxidation of 4-coumarate in cytosol
event
KEGG:C00811
http://purl.org/obo/owl/KEGG#KEGG_C00811
Peroxidation of 4-Coumaryl alcohol to Lignin (grasses) in cytosol
event
KEGG:C05615
http://purl.org/obo/owl/KEGG#KEGG_C05615
KEGG:C02646
http://purl.org/obo/owl/KEGG#KEGG_C02646
Translocation of Coniferyl alcohol to cell wall
event
KEGG:C00590
http://purl.org/obo/owl/KEGG#KEGG_C00590
Translocation of 4-Coumaryl alcohol to cell wall
event
KEGG:C02646
http://purl.org/obo/owl/KEGG#KEGG_C02646
O-methyltransferase of caffeoyl-CoA by CCR in cytosol
event
KEGG:R01942
http://purl.org/obo/owl/KEGG#KEGG_R01942
EC:2.1.1.104
http://purl.org/obo/owl/EC#EC_2.1.1.104
KEGG:C00323
http://purl.org/obo/owl/KEGG#KEGG_C00323
Hydroxylation of trans-cinnamate by C4H in the cytosol
event
KEGG:C00423
http://purl.org/obo/owl/KEGG#KEGG_C00423
Peroxidation of sinapyl alcohol to Lignin (angiosperm and grasses) in cytosol
event
KEGG:C05615
http://purl.org/obo/owl/KEGG#KEGG_C05615
KEGG:C02325
http://purl.org/obo/owl/KEGG#KEGG_C02325
CoA ligation of caffeic acid by 4CL in cytosol
event
KEGG:C00223
http://purl.org/obo/owl/KEGG#KEGG_C00223
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
EC:6.2.1.12
http://purl.org/obo/owl/EC#EC_6.2.1.12
KEGG:R01943
http://purl.org/obo/owl/KEGG#KEGG_R01943
KEGG:C01197
http://purl.org/obo/owl/KEGG#KEGG_C01197
CoA ligation of 4-coumarate by 4CL in cytosol
event
EC:6.2.1.12
http://purl.org/obo/owl/EC#EC_6.2.1.12
KEGG:R01616
http://purl.org/obo/owl/KEGG#KEGG_R01616
KEGG:C00811
http://purl.org/obo/owl/KEGG#KEGG_C00811
KEGG:C00223
http://purl.org/obo/owl/KEGG#KEGG_C00223
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
CoA ligation of ferulate by 4CL in cytosol
event
KEGG:R02194
http://purl.org/obo/owl/KEGG#KEGG_R02194
KEGG:C01494
http://purl.org/obo/owl/KEGG#KEGG_C01494
KEGG:C00223
http://purl.org/obo/owl/KEGG#KEGG_C00223
EC:6.2.1.12
http://purl.org/obo/owl/EC#EC_6.2.1.12
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
O-methyl-transfer of caffeic acid by OMT in cytosol
event
EC:2.1.1.68
http://purl.org/obo/owl/EC#EC_2.1.1.68
KEGG:R03366
http://purl.org/obo/owl/KEGG#KEGG_R03366
KEGG:C01197
http://purl.org/obo/owl/KEGG#KEGG_C01197
CoA ligation of 5-Hydroxyferulate by 4CL in cytosol
event
KEGG:R06583
http://purl.org/obo/owl/KEGG#KEGG_R06583
KEGG:C05619
http://purl.org/obo/owl/KEGG#KEGG_C05619
KEGG:C00223
http://purl.org/obo/owl/KEGG#KEGG_C00223
EC:6.2.1.12
http://purl.org/obo/owl/EC#EC_6.2.1.12
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
Peroxidation of coniferyl alcohol to Lignin (gymnosperm, angiosperm and grasses) in cytosol
event
KEGG:C00590
http://purl.org/obo/owl/KEGG#KEGG_C00590
KEGG:C05615
http://purl.org/obo/owl/KEGG#KEGG_C05615
Translocation of sinapyl alcohol to cell wall
event
KEGG:C02325
http://purl.org/obo/owl/KEGG#KEGG_C02325
Translocation from cytosol to cell wall
event
CoA ligation in cytosol
event
CoA ligation inside of the plasma membrane
event
CoA ligation in unidentified cellular location
event
Transmethylation
event
EC:2.1.1.-
http://purl.org/obo/owl/EC#EC_2.1.1.-
MI:0213
http://purl.org/obo/owl/MI#MI_0213
The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer. Irreversible reaction that can affect A,G,M,F,P,C,R,N,Q,E,H,or K residues.
MI:0213
http://purl.org/obo/owl/MI#MI_0213
Transmethylation in unidentified cellular location
event
Transmethylation in cytosol
event
Isoprenylation in cytosol
event
Hydroxylation
event
MI:0210
http://purl.org/obo/owl/MI#MI_0210
Irreversible reaction that can affect K,P,Y or R residues.
MI:0210
http://purl.org/obo/owl/MI#MI_0210
Hydroxylation in the cytosol
event
Hydroxylation in the unidentified cellular location
event
Farnesylation in cytosol
event
Lignin biosynthesis (angiosperm)
event
Lignin biosynthesis (gymnosperm)
event
Lignin biosynthesis (grasses)
event
Translocation of Bax from the cytosol to the mitochondria membrane
event
GO:0001844
http://purl.org/obo/owl/GO#GO_0001844
IMR:0000453
http://purl.org/obo/owl/IMR#IMR_0000453
REACT:1286.3
http://purl.org/obo/owl/REACT#REACT_1286.3
Translocation of activated BAX to the mitochondria
MAPKKK cascade
event
MAP kinase kinase kinase cascade
GO:0000165
http://purl.org/obo/owl/GO#GO_0000165
MAPK cascade
MAP kinase cascade
GO:0000165
http://purl.org/obo/owl/GO#GO_0000165
Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
GO:0000165
http://purl.org/obo/owl/GO#GO_0000165
GO:0000165
http://purl.org/obo/owl/GO#GO_0000165
KEGG:hsa04010
http://purl.org/obo/owl/KEGG#KEGG_hsa04010
Phosphorylation of STAT by JAK_p in cytosol
event
PubMed:12039028
http://purl.org/obo/owl/PubMed#PubMed_12039028
GO:0007260
http://purl.org/obo/owl/GO#GO_0007260
IMR:0000213
http://purl.org/obo/owl/IMR#IMR_0000213
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
Anatomical structure morphogenesis
event
GO:0009653
http://purl.org/obo/owl/GO#GO_0009653
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
GO:0009653
http://purl.org/obo/owl/GO#GO_0009653
anatomical structure organization
GO:0009653
http://purl.org/obo/owl/GO#GO_0009653
morphogenesis
GO:0009653
http://purl.org/obo/owl/GO#GO_0009653
Hematopoiesis
event
blood cell formation
blood cell biosynthesis
Hemopoiesis
GO:0030097
http://purl.org/obo/owl/GO#GO_0030097
Haemopoiesis
The process of blood cell formation. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
GO:0030097
http://purl.org/obo/owl/GO#GO_0030097
Negative regulation of Ras-Raf-MAPK signaling by spred (Drosophila)
event
OBSOLETE: remap to 'Negative regulation of Ras-Raf-MAPK signaling by spred' IEV:0003544.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Insulin receptor signaling pathway (through IRS mediated signaling)
event
Insulin receptor signaling pathway (through AKT-Bad signaling)
Phosphorylation of p53 by ATM in inner space of nucleus
event
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
UniProt:Q13315
http://purl.org/obo/owl/UniProt#UniProt_Q13315
IGF signaling pathway
event
PubMed:15205477
http://purl.org/obo/owl/PubMed#PubMed_15205477
The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands.
GO:0048009
http://purl.org/obo/owl/GO#GO_0048009
insulin-like growth factor receptor signaling pathway
GO:0048009
http://purl.org/obo/owl/GO#GO_0048009
GO:0048009
http://purl.org/obo/owl/GO#GO_0048009
IGF receptor signaling pathway
GO:0048009
http://purl.org/obo/owl/GO#GO_0048009
TNFR1 signaling pathway (through JNK cascade)
event
Binding of TRAF2 and ASK1 in cytosol
event
IMR:0100218
http://purl.org/obo/owl/IMR#IMR_0100218
IMR:0100423
http://purl.org/obo/owl/IMR#IMR_0100423
Binding of TRADD and FADD in cytosol
event
TRADD:TRAF2:RIP1 complex binds FADD
IMR:0100464
http://purl.org/obo/owl/IMR#IMR_0100464
IMR:0100463
http://purl.org/obo/owl/IMR#IMR_0100463
REACT:1766.1
http://purl.org/obo/owl/REACT#REACT_1766.1
Protein activation/inactivation signaling
event
Autophosphorylation in unidentified cellular location
event
T cell receptor signaling pathway
event
T-lymphocyte receptor signaling pathway
GO:0050852
http://purl.org/obo/owl/GO#GO_0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
GO:0050852
http://purl.org/obo/owl/GO#GO_0050852
T-cell receptor signaling pathway
GO:0050852
http://purl.org/obo/owl/GO#GO_0050852
GO:0050852
http://purl.org/obo/owl/GO#GO_0050852
T lymphocyte receptor signaling pathway
GO:0050852
http://purl.org/obo/owl/GO#GO_0050852
KEGG:hsa04660
http://purl.org/obo/owl/KEGG#KEGG_hsa04660
Regulation of p53 signaling pathway
event
Toll-like receptor signaling pathway
Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses.
event
Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
GO:0002224
http://purl.org/obo/owl/GO#GO_0002224
KEGG:hsa04620
http://purl.org/obo/owl/KEGG#KEGG_hsa04620
GO:0002224
http://purl.org/obo/owl/GO#GO_0002224
TLR signaling pathway
GO:0002224
http://purl.org/obo/owl/GO#GO_0002224
Negative regulation of p53 signaling pathway
event
Positive regulation of p53 signaling pathway
event
TNFR signaling pathway
event
KEGG:hsa04210
http://purl.org/obo/owl/KEGG#KEGG_hsa04210
induction of apoptosis by extracellular signals
KEGG:mmu04210
http://purl.org/obo/owl/KEGG#KEGG_mmu04210
Extrinsic Pathway for Apoptosis
KEGG:rno04210
http://purl.org/obo/owl/KEGG#KEGG_rno04210
Death Receptor Signalling
Nuclear import of ERK_p
event
IMR:0000227
http://purl.org/obo/owl/IMR#IMR_0000227
PLC gamma signaling
T cell=PLC gamma1, B cell=gamma2, PDGFR=PLC gamma1
IEV:0000271
IEV:0000058
event
IEV:0000468
PLC gamma signaling (through LAT)
PLC gamma signaling (through RTK)
PLC gamma signaling (through BLNK)
PubMed:10579907
http://purl.org/obo/owl/PubMed#PubMed_10579907
Binding of PLC gamma and PIP3 in cytosol
event
IMR:0000285
http://purl.org/obo/owl/IMR#IMR_0000285
activation of PLC gamma, PLC gamma_SH2 or PH domain
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
IMR:0001352
http://purl.org/obo/owl/IMR#IMR_0001352
Binding of PLC beta and PIP3 in cytosol
event
IMR:0001352
http://purl.org/obo/owl/IMR#IMR_0001352
IMR:0000286
http://purl.org/obo/owl/IMR#IMR_0000286
PLC signaling
event
phospholipase C signaling
Hydrolysis of PIP2 by PLC to generate DAG and IP3 in cytosol
event
IMR:0100027
http://purl.org/obo/owl/IMR#IMR_0100027
IMR:0100028
http://purl.org/obo/owl/IMR#IMR_0100028
IMR:0000284
http://purl.org/obo/owl/IMR#IMR_0000284
IMR:0001350
http://purl.org/obo/owl/IMR#IMR_0001350
Hydrolysis of PIP2 by PLC beta to generate DAG and IP3 in cytosol
event
IMR:0100027
http://purl.org/obo/owl/IMR#IMR_0100027
IMR:0100028
http://purl.org/obo/owl/IMR#IMR_0100028
IMR:0001350
http://purl.org/obo/owl/IMR#IMR_0001350
IMR:0000286
http://purl.org/obo/owl/IMR#IMR_0000286
Phosphorylation of MAPKK by MAPKKK in cytosol
event
IEV:0002094
The initiation of the activity of the inactive enzyme MAP kinase kinase by phosphorylation by a MAPKKK.
GO:0000186
http://purl.org/obo/owl/GO#GO_0000186
IMR:0000259
http://purl.org/obo/owl/IMR#IMR_0000259
activation of MAPKK activity
GO:0000186
http://purl.org/obo/owl/GO#GO_0000186
Phosphorylation of MKK by MAPKKK
IMR:0000229
http://purl.org/obo/owl/IMR#IMR_0000229
GO:0000186
http://purl.org/obo/owl/GO#GO_0000186
Phosphorylation of MEK1/2(MKK1/2) by MAPKKK in cytosol
event
IMR:0000229
http://purl.org/obo/owl/IMR#IMR_0000229
IMR:0000261
http://purl.org/obo/owl/IMR#IMR_0000261
Phosphorylation of ERK by MEK1/2(MKK1/2)_p in cytosol
event
IMR:0000261
http://purl.org/obo/owl/IMR#IMR_0000261
IMR:0000227
http://purl.org/obo/owl/IMR#IMR_0000227
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
Phosphorylation of transcriptional regulator by ERK_p in inner space of nucleus
event
IMR:0000227
http://purl.org/obo/owl/IMR#IMR_0000227
IMR:0000369
http://purl.org/obo/owl/IMR#IMR_0000369
Phosphorylation of MAPK by MAPKK in cytosol
event
The initiation of the activity of the inactive enzyme MAP kinase by phosphorylation by a MAPKK.
GO:0000187
http://purl.org/obo/owl/GO#GO_0000187
activation of MAP kinase
IMR:0000259
http://purl.org/obo/owl/IMR#IMR_0000259
activation of MAPK activity
IMR:0000224
http://purl.org/obo/owl/IMR#IMR_0000224
GO:0000187
http://purl.org/obo/owl/GO#GO_0000187
Phosphorylation of transcriptional regulator by MAPK_p in inner space of nucleus
event
Dually phosphorylated MAPK, or dpERK, phosphorylates protein targets in both the cytoplasm and nucleus.
PubMed:16771628
http://purl.org/obo/owl/PubMed#PubMed_16771628
IMR:0000369
http://purl.org/obo/owl/IMR#IMR_0000369
IMR:0000224
http://purl.org/obo/owl/IMR#IMR_0000224
Nuclear import of MAPK (through MAPKKK cascade)
event
nuclear translocation of MAPK
IMR:0000224
http://purl.org/obo/owl/IMR#IMR_0000224
GO:0000189
http://purl.org/obo/owl/GO#GO_0000189
The directed movement of a MAP kinase to the nucleus upon activation.
GO:0000189
http://purl.org/obo/owl/GO#GO_0000189
Autophosphorylation in cytosol
event
CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
event
CD4 T cell receptor signaling pathway (through PLC gamma, calcineurin and NF-AT)
Binding of calcium ion and PKC and active conformational change of PKC in cytosol
event
PubMed:7499357
http://purl.org/obo/owl/PubMed#PubMed_7499357
IMR:0100031
http://purl.org/obo/owl/IMR#IMR_0100031
IMR:0000245
http://purl.org/obo/owl/IMR#IMR_0000245
Binding of DAG, calcium ion and PKC and active conformational change of PKC in cytosol
event
PubMed:7499357
http://purl.org/obo/owl/PubMed#PubMed_7499357
IMR:0100031
http://purl.org/obo/owl/IMR#IMR_0100031
IMR:0100027
http://purl.org/obo/owl/IMR#IMR_0100027
IMR:0000245
http://purl.org/obo/owl/IMR#IMR_0000245
Transcription of IL-2 in nucleus
event
PubMed:11973130
http://purl.org/obo/owl/PubMed#PubMed_11973130
IMR:0000008
http://purl.org/obo/owl/IMR#IMR_0000008
Autophosphorylation in plasma membrane
event
Insulin receptor signaling pathway
event
GO:0008286
http://purl.org/obo/owl/GO#GO_0008286
REACT:498.5
http://purl.org/obo/owl/REACT#REACT_498.5
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
GO:0008286
http://purl.org/obo/owl/GO#GO_0008286
Insulin receptor mediated signalling
Binding of insulin and insulin receptor in extracellular
event
IMR:0000078
http://purl.org/obo/owl/IMR#IMR_0000078
REACT:1459.4
http://purl.org/obo/owl/REACT#REACT_1459.4
IMR:0000052
http://purl.org/obo/owl/IMR#IMR_0000052
Insulin binding
Autophosphorylation of insulin receptor in plasma membrane
event
REACT:2211.3
http://purl.org/obo/owl/REACT#REACT_2211.3
IMR:0000078
http://purl.org/obo/owl/IMR#IMR_0000078
Autophosphorylation
event
GO:0046777
http://purl.org/obo/owl/GO#GO_0046777
Binding of insulin receptor and Shc in cytosol
event
IMR:0000078
http://purl.org/obo/owl/IMR#IMR_0000078
Binding of SHC to insulin receptor
REACT:106.2
http://purl.org/obo/owl/REACT#REACT_106.2
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
Phosphorylation of Shc by insulin receptor in cytosol
event
IMR:0000078
http://purl.org/obo/owl/IMR#IMR_0000078
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
REACT:2015.2
http://purl.org/obo/owl/REACT#REACT_2015.2
Phosphorylation of SHC
Dissociation of Shc and insulin receptor in cytosol
event
IMR:0000078
http://purl.org/obo/owl/IMR#IMR_0000078
Dissociation of SHC-P from insulin receptor
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
REACT:596.2
http://purl.org/obo/owl/REACT#REACT_596.2
Binding of IRS and insulin receptor in cytosol
event
REACT:2120.3
http://purl.org/obo/owl/REACT#REACT_2120.3
IMR:0000078
http://purl.org/obo/owl/IMR#IMR_0000078
IMR:0000351
http://purl.org/obo/owl/IMR#IMR_0000351
Binding of IRS to insulin receptor
Phosphorylation of IRS by insulin receptor in cytosol
event
Phosphorylation of IRS
IMR:0000078
http://purl.org/obo/owl/IMR#IMR_0000078
IMR:0000351
http://purl.org/obo/owl/IMR#IMR_0000351
REACT:342.3
http://purl.org/obo/owl/REACT#REACT_342.3
Dissociation of IRS and insulin receptor in cytosol
event
IMR:0000351
http://purl.org/obo/owl/IMR#IMR_0000351
REACT:562.2
http://purl.org/obo/owl/REACT#REACT_562.2
IMR:0000078
http://purl.org/obo/owl/IMR#IMR_0000078
Dissociation of IRS-P from insulin receptor
Internalisation of the insulin receptor
event
REACT:599.2
http://purl.org/obo/owl/REACT#REACT_599.2
IMR:0000078
http://purl.org/obo/owl/IMR#IMR_0000078
Insulin receptor recycling
event
REACT:1109.2
http://purl.org/obo/owl/REACT#REACT_1109.2
Influx of hydrogen ion into the lumen of the endosome by proton pump
event
Endosome acidification
IMR:0001051
http://purl.org/obo/owl/IMR#IMR_0001051
REACT:2002.3
http://purl.org/obo/owl/REACT#REACT_2002.3
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
Dissociation of insulin and insulin receptor in extracellular
event
Dissociation of insulin from insulin receptor
REACT:134.2
http://purl.org/obo/owl/REACT#REACT_134.2
IMR:0000078
http://purl.org/obo/owl/IMR#IMR_0000078
IMR:0000052
http://purl.org/obo/owl/IMR#IMR_0000052
Negative regulation of insulin signaling pathway
event
Any process that stops, prevents or reduces the frequency, rate or extent of insulin receptor signaling.
GO:0046627
http://purl.org/obo/owl/GO#GO_0046627
GO:0046627
http://purl.org/obo/owl/GO#GO_0046627
Dephosphorylation of Insulin receptor by PTP in cytosol
event
IMR:0000078
http://purl.org/obo/owl/IMR#IMR_0000078
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
REACT:453.3
http://purl.org/obo/owl/REACT#REACT_453.3
Insulin receptor de-phosphorylation
Translocation of insulin receptor from the endosome to plasma membrane
event
IMR:0000078
http://purl.org/obo/owl/IMR#IMR_0000078
Re-integration of insulin receptor into plasma membrane
REACT:490.2
http://purl.org/obo/owl/REACT#REACT_490.2
Translocation from cytosol into lumen of endosome
event
Translocation from endosome to plasma membrane
event
Dissociation in extracellular
event
Dissociation in unidentified cellular location
event
Translocation from plasma membrane to cytosol
event
Dephosphorylation of Lck_p by CD45 and active conformational change
event
PubMed:11781344
http://purl.org/obo/owl/PubMed#PubMed_11781344
IMR:0100353
http://purl.org/obo/owl/IMR#IMR_0100353
IMR:0001045
http://purl.org/obo/owl/IMR#IMR_0001045
Dephosphorylation of Lck_p (phosphorylated in the C-terminal phosphorylation site) by CD45 and active conformational change
PubMed:12040176
http://purl.org/obo/owl/PubMed#PubMed_12040176
Autophosphorylation of Lck and active conformational change in cytosol
event
IMR:0100353
http://purl.org/obo/owl/IMR#IMR_0100353
PubMed:11781344
http://purl.org/obo/owl/PubMed#PubMed_11781344
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
Binding of CD4 and Lck in extracellular
event
IMR:0100353
http://purl.org/obo/owl/IMR#IMR_0100353
PubMed:15343367
http://purl.org/obo/owl/PubMed#PubMed_15343367
IMR:0100294
http://purl.org/obo/owl/IMR#IMR_0100294
Negative regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
event
Negative regulation of CD4 T cell receptor signaling pathway (through PLC gamma, PKC and IKK-NF-kappaB cascade)
Lck inactivation signaling (through PTP)
event
PubMed:11781344
http://purl.org/obo/owl/PubMed#PubMed_11781344
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
PubMed:12040176
http://purl.org/obo/owl/PubMed#PubMed_12040176
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
Phosphorylation of PAG/Cbp by Fyn in cytosol
event
IMR:0100346
http://purl.org/obo/owl/IMR#IMR_0100346
IMR:0100352
http://purl.org/obo/owl/IMR#IMR_0100352
PubMed:11781344
http://purl.org/obo/owl/PubMed#PubMed_11781344
Binding of PAG/Cbp_p and Csk in cytosol
event
PubMed:11781344
http://purl.org/obo/owl/PubMed#PubMed_11781344
IMR:0100346
http://purl.org/obo/owl/IMR#IMR_0100346
IMR:0000212
http://purl.org/obo/owl/IMR#IMR_0000212
Binding of Csk and PEP in cytosol
event
IMR:0100342
http://purl.org/obo/owl/IMR#IMR_0100342
PubMed:11781344
http://purl.org/obo/owl/PubMed#PubMed_11781344
IMR:0000212
http://purl.org/obo/owl/IMR#IMR_0000212
DNA fragmentation by EndoG in inner space of nucleus
event
UniProt:Q14249
http://purl.org/obo/owl/UniProt#UniProt_Q14249
Dephosphorylation of Lck_p by PEP in cytosol
event
PubMed:11781344
http://purl.org/obo/owl/PubMed#PubMed_11781344
IMR:0100353
http://purl.org/obo/owl/IMR#IMR_0100353
IMR:0100342
http://purl.org/obo/owl/IMR#IMR_0100342
Dephosphorylation of Lck_p (autophosphorylated) by PEP in cytosol
Lck activation signaling (through autophosphorylation and PTP)
event
PubMed:11781344
http://purl.org/obo/owl/PubMed#PubMed_11781344
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
PubMed:12040176
http://purl.org/obo/owl/PubMed#PubMed_12040176
Regulation of Src family activation signaling
event
Binding of antigen and MHC II in extracellular
event
PubMed:15343367
http://purl.org/obo/owl/PubMed#PubMed_15343367
IMR:0000465
http://purl.org/obo/owl/IMR#IMR_0000465
IMR:0000144
http://purl.org/obo/owl/IMR#IMR_0000144
Phosphorylation of CD3 zeta by Lck_p in cytosol
event
IMR:0100353
http://purl.org/obo/owl/IMR#IMR_0100353
IMR:0100287
http://purl.org/obo/owl/IMR#IMR_0100287
PubMed:12040176
http://purl.org/obo/owl/PubMed#PubMed_12040176
Phosphorylation of CD3 zeta by Lck (autophosphorylated) in cytosol
Phosphorylation of CD3 zeta by Fyn_p in cytosol
event
IMR:0100352
http://purl.org/obo/owl/IMR#IMR_0100352
Phosphorylation of CD3 zeta by Fyn (autophosphorylated) in cytosol
IMR:0100287
http://purl.org/obo/owl/IMR#IMR_0100287
Binding of CD3 zeta and ZAP-70 in cytosol
IEV:0000261
event
PubMed:15343367
http://purl.org/obo/owl/PubMed#PubMed_15343367
IMR:0100287
http://purl.org/obo/owl/IMR#IMR_0100287
IMR:0000221
http://purl.org/obo/owl/IMR#IMR_0000221
Binding of TCR-CD3 complex and Zap-70
Phosphorylation of ZAP-70 by Fyn_p in cytosol
event
Phosphorylation of ZAP-70 by autophosphorylated Fyn in cytosol
IMR:0100352
http://purl.org/obo/owl/IMR#IMR_0100352
IMR:0000221
http://purl.org/obo/owl/IMR#IMR_0000221
Dephosphorylation of ZAP-70_p by SHIP-1 in cytosol
event
IMR:0000271
http://purl.org/obo/owl/IMR#IMR_0000271
IMR:0000221
http://purl.org/obo/owl/IMR#IMR_0000221
Phosphorylation of SLP-76 by ZAP-70_p in cytosol
event
IEV:0000290
PubMed:15343367
http://purl.org/obo/owl/PubMed#PubMed_15343367
IMR:0000350
http://purl.org/obo/owl/IMR#IMR_0000350
IMR:0000221
http://purl.org/obo/owl/IMR#IMR_0000221
Phosphorylation of SLP-76 by Zap-70
Binding of Gads and SLP-76 in cytosol
event
IMR:0000350
http://purl.org/obo/owl/IMR#IMR_0000350
PubMed:15343367
http://purl.org/obo/owl/PubMed#PubMed_15343367
IMR:0000741
http://purl.org/obo/owl/IMR#IMR_0000741
Phosphorylation of PLC gamma1 by Itk in cytosol
event
PubMed:11752630
http://purl.org/obo/owl/PubMed#PubMed_11752630
T-cell
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
IMR:0000732
http://purl.org/obo/owl/IMR#IMR_0000732
IMR:0100354
http://purl.org/obo/owl/IMR#IMR_0100354
Phosphorylation of PLC gamma by Syk in cytosol
event
IMR:0000222
http://purl.org/obo/owl/IMR#IMR_0000222
IMR:0000285
http://purl.org/obo/owl/IMR#IMR_0000285
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
Binding of SLP-76 and Itk in cytosol
event
IMR:0000350
http://purl.org/obo/owl/IMR#IMR_0000350
IMR:0100354
http://purl.org/obo/owl/IMR#IMR_0100354
PubMed:12040176
http://purl.org/obo/owl/PubMed#PubMed_12040176
Phosphorylation of PI by PI4K in plasma membrane
event
IMR:0100699
http://purl.org/obo/owl/IMR#IMR_0100699
IMR:0001651
http://purl.org/obo/owl/IMR#IMR_0001651
Phosphorylation of PIP by PI5K in plasma membrane
event
IMR:0000268
http://purl.org/obo/owl/IMR#IMR_0000268
IMR:0001348
http://purl.org/obo/owl/IMR#IMR_0001348
Binding of PIP2 and actin-binding protein in cytosol
event
IMR:0001350
http://purl.org/obo/owl/IMR#IMR_0001350
Fyn activation signaling (through autophosphorylation and PTP)
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
Autophosphorylation of Fyn and active conformational change in cytosol
event
IMR:0100352
http://purl.org/obo/owl/IMR#IMR_0100352
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
Interaction in nucleus
event
OBSOLETE: remap to 'Unknown interaction' IEV:0000922.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Regulation of BAD inactivation signaling
event
Regulation of BAD phosphorylation signaling
Regulation of Caspase cascade
event
Positive regulation of BAD inactivation signaling
event
Positive regulation of BAD phosphorylation signaling
Positive regulation of Caspase cascade (through mitochondria)
event
Regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
event
Regulation of CD4 T cell receptor signaling pathway (through PLC gamma, PKC and IKK-NF-kappaB cascade)
Positive regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
event
Positive regulation of CD4 T cell receptor signaling pathway (through PLC gamma, PKC and IKK-NF-kappaB cascade)
Regulation of Fas signaling pathway
event
Positive regulation of Fas signaling pathway
event
Regulation of G1-S-phase transition
event
Positive regulation of G1-S-phase transition
event
Regulation of insulin receptor signaling pathway
event
GO:0046626
http://purl.org/obo/owl/GO#GO_0046626
Any process that modulates the frequency, rate or extent of insulin receptor signaling.
GO:0046626
http://purl.org/obo/owl/GO#GO_0046626
Positive regulation of insulin receptor signaling pathway
event
GO:0046628
http://purl.org/obo/owl/GO#GO_0046628
Any process that increases the frequency, rate or extent of insulin receptor signaling.
GO:0046628
http://purl.org/obo/owl/GO#GO_0046628
Regulation of JAK STAT pathway
event
GO:0046425
http://purl.org/obo/owl/GO#GO_0046425
Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway.
GO:0046425
http://purl.org/obo/owl/GO#GO_0046425
Positive regulation of JAK STAT pathway
event
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
GO:0046427
http://purl.org/obo/owl/GO#GO_0046427
GO:0046427
http://purl.org/obo/owl/GO#GO_0046427
Regulation of NF-kappaB signaling (cytoplasmic sequestering)
event
Positive regulation of NF-kappaB signaling (cytoplasmic sequestering)
event
Regulation of PLC gamma signaling
event
Positive regulation of PLC gamma signaling (through LAT)
event
Regulation of Ras-Raf-MAPK signaling by spred [Drosophila]
event
OBSOLETE: remap to 'Regulation of Ras-Raf-MAPK signaling by spred' IEV:0003543.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Positive regulation of Ras-Raf-MAPK signaling by spred (Drosophila)
event
OBSOLETE: remap to 'Positive regulation of Ras-Raf-MAPK signaling by spred' IEV:0003545.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Fyn inactivation signaling (through PTP)
event
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
PubMed:11781344
http://purl.org/obo/owl/PubMed#PubMed_11781344
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Negative regulation of Src family activation signaling
event
Positive regulation of Src family activation signaling
event
ZAP-70 and CD3 degradation signaling
event
PubMed:11724969
http://purl.org/obo/owl/PubMed#PubMed_11724969
Ubiquitination of ZAP-70 by c-Cbl in cytosol
event
IMR:0100344
http://purl.org/obo/owl/IMR#IMR_0100344
PubMed:11724969
http://purl.org/obo/owl/PubMed#PubMed_11724969
IMR:0000221
http://purl.org/obo/owl/IMR#IMR_0000221
Ubiquitination of CD3_p by c-Cbl in cytosol
event
PubMed:11724969
http://purl.org/obo/owl/PubMed#PubMed_11724969
IMR:0100344
http://purl.org/obo/owl/IMR#IMR_0100344
IMR:0000147
http://purl.org/obo/owl/IMR#IMR_0000147
Proteasome degradation of ZAP-70 by 26S proteasome in cytosol
event
PubMed:11724969
http://purl.org/obo/owl/PubMed#PubMed_11724969
IMR:0000221
http://purl.org/obo/owl/IMR#IMR_0000221
IMR:0000310
http://purl.org/obo/owl/IMR#IMR_0000310
Proteasome degradation of CD3 by 26S proteasome in cytosol
event
PubMed:11724969
http://purl.org/obo/owl/PubMed#PubMed_11724969
IMR:0000310
http://purl.org/obo/owl/IMR#IMR_0000310
IMR:0000147
http://purl.org/obo/owl/IMR#IMR_0000147
Syk degradation signaling
event
PubMed:12024036
http://purl.org/obo/owl/PubMed#PubMed_12024036
Ubiquitination of Syk by c-Cbl in cytosol
event
IMR:0100344
http://purl.org/obo/owl/IMR#IMR_0100344
IMR:0000222
http://purl.org/obo/owl/IMR#IMR_0000222
PubMed:12024036
http://purl.org/obo/owl/PubMed#PubMed_12024036
Proteasome degradation of Syk by 26S proteasome in cytosol
event
PubMed:12024036
http://purl.org/obo/owl/PubMed#PubMed_12024036
IMR:0000310
http://purl.org/obo/owl/IMR#IMR_0000310
IMR:0000222
http://purl.org/obo/owl/IMR#IMR_0000222
Lck degradation signaling
event
PubMed:11904433
http://purl.org/obo/owl/PubMed#PubMed_11904433
Ubiquitination of Lck by c-Cbl in cytosol
event
IMR:0100344
http://purl.org/obo/owl/IMR#IMR_0100344
IMR:0100353
http://purl.org/obo/owl/IMR#IMR_0100353
PubMed:11904433
http://purl.org/obo/owl/PubMed#PubMed_11904433
Proteasome degradation of Lck by 26S proteasome in cytosol
event
IMR:0100353
http://purl.org/obo/owl/IMR#IMR_0100353
IMR:0000310
http://purl.org/obo/owl/IMR#IMR_0000310
PubMed:11904433
http://purl.org/obo/owl/PubMed#PubMed_11904433
Binding of PACAP and PACAP receptor in cytosol
event
REACT:18424.1
http://purl.org/obo/owl/REACT#REACT_18424.1
UniProt:P18509
http://purl.org/obo/owl/UniProt#UniProt_P18509
UniProt:P41586
http://purl.org/obo/owl/UniProt#UniProt_P41586
Phosphorylation of ZAP-70 by non-receptor tyrosine kinase in cytosol
event
PubMed:12040176
http://purl.org/obo/owl/PubMed#PubMed_12040176
PubMed:15343367
http://purl.org/obo/owl/PubMed#PubMed_15343367
IMR:0000682
http://purl.org/obo/owl/IMR#IMR_0000682
IMR:0000221
http://purl.org/obo/owl/IMR#IMR_0000221
Embryonic morphogenesis
event
GO:0048598
http://purl.org/obo/owl/GO#GO_0048598
The developmental processes by which defined structures within an embryo are generated.
GO:0048598
http://purl.org/obo/owl/GO#GO_0048598
Post-embryonic morphogenesis
event
GO:0009886
http://purl.org/obo/owl/GO#GO_0009886
The process, occurring after embryonic development, by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
GO:0009886
http://purl.org/obo/owl/GO#GO_0009886
post-embryonic morphogenesis of an anatomical structure
Organ morphogenesis
event
histogenesis and organogenesis
GO:0009887
http://purl.org/obo/owl/GO#GO_0009887
Morphogenesis of a tissue or tissues that function together to perform a specific function. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function.
GO:0009887
http://purl.org/obo/owl/GO#GO_0009887
GO:0009887
http://purl.org/obo/owl/GO#GO_0009887
Flower morphogenesis
event
GO:0048439
http://purl.org/obo/owl/GO#GO_0048439
The process by which the anatomical structures of the flower are generated and organized. Morphogenesis pertains to the creation of form.
GO:0048439
http://purl.org/obo/owl/GO#GO_0048439
Tissue regeneration
IEV:0000100
event
GO:0042246
http://purl.org/obo/owl/GO#GO_0042246
Tissue repair
The regrowth of lost or destroyed tissues.
GO:0042246
http://purl.org/obo/owl/GO#GO_0042246
Binding of extracellular matrix and Integrin complex in extracellular
event
IMR:0000172
http://purl.org/obo/owl/IMR#IMR_0000172
Binding of extracellular matrix protein and integrin complex in extracellular
event
IMR:0000172
http://purl.org/obo/owl/IMR#IMR_0000172
IMR:0000540
http://purl.org/obo/owl/IMR#IMR_0000540
Complex formation of integrin complex and caveolin in plasma membrane
event
IMR:0000515
http://purl.org/obo/owl/IMR#IMR_0000515
IMR:0000172
http://purl.org/obo/owl/IMR#IMR_0000172
Integrin complex and caveolin complex formation
Binding of integrin complex and talin in cytosol
event
IMR:0001714
http://purl.org/obo/owl/IMR#IMR_0001714
IMR:0000172
http://purl.org/obo/owl/IMR#IMR_0000172
Complex formation of integrin-dependent membrane-skeletal protein in cytosol
event
IMR:0000185
http://purl.org/obo/owl/IMR#IMR_0000185
Binding of integrin complex and FAK in cytosol
event
IMR:0000172
http://purl.org/obo/owl/IMR#IMR_0000172
IMR:0000218
http://purl.org/obo/owl/IMR#IMR_0000218
Binding of Integrin complex and tensin in cytosol
event
IMR:0000172
http://purl.org/obo/owl/IMR#IMR_0000172
UniProt:Q9HBL0
http://purl.org/obo/owl/UniProt#UniProt_Q9HBL0
Binding of FAK and paxillin in cytosol
event
IMR:0000218
http://purl.org/obo/owl/IMR#IMR_0000218
IMR:0000187
http://purl.org/obo/owl/IMR#IMR_0000187
Binding of FAK and p130Cas in cytosol
event
IMR:0000355
http://purl.org/obo/owl/IMR#IMR_0000355
IMR:0000218
http://purl.org/obo/owl/IMR#IMR_0000218
Binding of alpha-actinin and F actin in cytosol
event
IMR:0000190
http://purl.org/obo/owl/IMR#IMR_0000190
IMR:0000189
http://purl.org/obo/owl/IMR#IMR_0000189
Binding of tensin and F actin in cytosol
event
UniProt:Q9HBL0
http://purl.org/obo/owl/UniProt#UniProt_Q9HBL0
IMR:0000190
http://purl.org/obo/owl/IMR#IMR_0000190
Binding of vinculin and F actin in cytosol
event
IMR:0000190
http://purl.org/obo/owl/IMR#IMR_0000190
IMR:0001711
http://purl.org/obo/owl/IMR#IMR_0001711
PubMed:8632828
http://purl.org/obo/owl/PubMed#PubMed_8632828
Binding of talin and F actin in cytosol
event
IMR:0000190
http://purl.org/obo/owl/IMR#IMR_0000190
IMR:0001714
http://purl.org/obo/owl/IMR#IMR_0001714
Binding of alpha-actinin and zyxin in cytosol
event
IMR:0000189
http://purl.org/obo/owl/IMR#IMR_0000189
UniProt:Q15942
http://purl.org/obo/owl/UniProt#UniProt_Q15942
Autophosphorylation of FAK in cytosol
event
IMR:0000218
http://purl.org/obo/owl/IMR#IMR_0000218
Phosphorylation of FAK by Src family in cytosol
event
IMR:0000211
http://purl.org/obo/owl/IMR#IMR_0000211
IMR:0000218
http://purl.org/obo/owl/IMR#IMR_0000218
Phosphorylation of p130Cas by Src family in cytosol
event
IMR:0000355
http://purl.org/obo/owl/IMR#IMR_0000355
IMR:0000211
http://purl.org/obo/owl/IMR#IMR_0000211
Phosphorylation of paxillin by Src family in cytosol
event
IMR:0000187
http://purl.org/obo/owl/IMR#IMR_0000187
IMR:0000211
http://purl.org/obo/owl/IMR#IMR_0000211
Binding of FAK and Src family in cytosol
event
IMR:0000218
http://purl.org/obo/owl/IMR#IMR_0000218
IMR:0000211
http://purl.org/obo/owl/IMR#IMR_0000211
Binding of p130Cas and Crk in cytosol
event
IMR:0000355
http://purl.org/obo/owl/IMR#IMR_0000355
IMR:0000335
http://purl.org/obo/owl/IMR#IMR_0000335
Binding of FAK and Grb2 in cytosol
event
IMR:0000218
http://purl.org/obo/owl/IMR#IMR_0000218
IMR:0000340
http://purl.org/obo/owl/IMR#IMR_0000340
Binding of Fyn and Shc in cytosol
event
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
IMR:0100352
http://purl.org/obo/owl/IMR#IMR_0100352
Phosphorylation of Shc by Fyn in cytosol
event
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
IMR:0100352
http://purl.org/obo/owl/IMR#IMR_0100352
Raf activation signaling (through Grb2 and Sos)
event
Grb2-Sos-Ras-Raf signaling
Binding of Grb2 and Sos in cytosol
event
PubMed:15220003
http://purl.org/obo/owl/PubMed#PubMed_15220003
IMR:0000435
http://purl.org/obo/owl/IMR#IMR_0000435
IMR:0000340
http://purl.org/obo/owl/IMR#IMR_0000340
GDP-GTP exchange of Ras by Sos in cytosol
event
IMR:0000290
http://purl.org/obo/owl/IMR#IMR_0000290
IMR:0000435
http://purl.org/obo/owl/IMR#IMR_0000435
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
PubMed:15220003
http://purl.org/obo/owl/PubMed#PubMed_15220003
GDP-GTP exchange in cytosol
event
GDP-GTP exchange in unidentified cellular location
event
Transference in cytosol
event
Activation of Raf by Ras-GTP in cytosol
event
IMR:0000231
http://purl.org/obo/owl/IMR#IMR_0000231
IMR:0000290
http://purl.org/obo/owl/IMR#IMR_0000290
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Binding of Ras-GTP and PI3K in cytosol
event
IMR:0000265
http://purl.org/obo/owl/IMR#IMR_0000265
IMR:0000290
http://purl.org/obo/owl/IMR#IMR_0000290
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Regulation of integrin signaling pathway
event
Negative regulation of integrin signaling pathway
event
Positive regulation of integrin signaling pathway
event
Dephosphorylation of FAK by PTEN in cytosol
event
IMR:0000218
http://purl.org/obo/owl/IMR#IMR_0000218
IMR:0100701
http://purl.org/obo/owl/IMR#IMR_0100701
Binding of Shc_p and Grb2 in cytosol
event
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
IMR:0000340
http://purl.org/obo/owl/IMR#IMR_0000340
Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
event
KEGG:hsa04510
http://purl.org/obo/owl/KEGG#KEGG_hsa04510
Integrin signaling pathway (through Rho)
event
KEGG:mmu04810
http://purl.org/obo/owl/KEGG#KEGG_mmu04810
KEGG:hsa04510
http://purl.org/obo/owl/KEGG#KEGG_hsa04510
KEGG:hsa04810
http://purl.org/obo/owl/KEGG#KEGG_hsa04810
KEGG:rno04810
http://purl.org/obo/owl/KEGG#KEGG_rno04810
Phosphorylation of ERK by FAK in cytosol
event
IMR:0000227
http://purl.org/obo/owl/IMR#IMR_0000227
IMR:0000218
http://purl.org/obo/owl/IMR#IMR_0000218
Integrin signaling pathway (through Rac and JNK cascade)
event
KEGG:hsa04510
http://purl.org/obo/owl/KEGG#KEGG_hsa04510
Activation of MLCK by ERK_p in cytosol
event
UniProt:Q15746
http://purl.org/obo/owl/UniProt#UniProt_Q15746
IMR:0000227
http://purl.org/obo/owl/IMR#IMR_0000227
Binding of integrin complex and Ilk in cytosol
event
UniProt:Q13418
http://purl.org/obo/owl/UniProt#UniProt_Q13418
IMR:0000172
http://purl.org/obo/owl/IMR#IMR_0000172
Binding of FAK and PI3K in cytosol
event
IMR:0000218
http://purl.org/obo/owl/IMR#IMR_0000218
PI3K approaching to the plasma membrane
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
IMR:0000265
http://purl.org/obo/owl/IMR#IMR_0000265
Binding of PIP3 and AKT
event
IMR:0000250
http://purl.org/obo/owl/IMR#IMR_0000250
IMR:0001352
http://purl.org/obo/owl/IMR#IMR_0001352
Phosphorylation of AKT by IlK in cytosol
event
UniProt:Q13418
http://purl.org/obo/owl/UniProt#UniProt_Q13418
IMR:0000250
http://purl.org/obo/owl/IMR#IMR_0000250
Phosphorylation outside the mitochondria membrane
event
Binding of PIP3 and PDK1
event
IMR:0001352
http://purl.org/obo/owl/IMR#IMR_0001352
IMR:0000255
http://purl.org/obo/owl/IMR#IMR_0000255
Phosphorylation of Vav by Syk in cytosol
event
IMR:0000434
http://purl.org/obo/owl/IMR#IMR_0000434
IMR:0000222
http://purl.org/obo/owl/IMR#IMR_0000222
PubMed:9843681
http://purl.org/obo/owl/PubMed#PubMed_9843681
GDP-GTP exchange of Rac by Vav in cytosol
event
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
PubMed:15343367
http://purl.org/obo/owl/PubMed#PubMed_15343367
PubMed:12818159
http://purl.org/obo/owl/PubMed#PubMed_12818159
IMR:0000297
http://purl.org/obo/owl/IMR#IMR_0000297
IMR:0000434
http://purl.org/obo/owl/IMR#IMR_0000434
Activation of PAK by Rac in cytosol
event
IMR:0000238
http://purl.org/obo/owl/IMR#IMR_0000238
IMR:0000297
http://purl.org/obo/owl/IMR#IMR_0000297
Phosphorylation of MAPKKK by PAK in cytosol
event
IMR:0000229
http://purl.org/obo/owl/IMR#IMR_0000229
IMR:0000238
http://purl.org/obo/owl/IMR#IMR_0000238
Binding of Crk and C3G in cytosol
event
IMR:0000335
http://purl.org/obo/owl/IMR#IMR_0000335
IMR:0000436
http://purl.org/obo/owl/IMR#IMR_0000436
PubMed:11804588
http://purl.org/obo/owl/PubMed#PubMed_11804588
GDP-GTP exchange of Rap1 by C3G in cytosol
event
PubMed:9560161
http://purl.org/obo/owl/PubMed#PubMed_9560161
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000436
http://purl.org/obo/owl/IMR#IMR_0000436
IMR:0001504
http://purl.org/obo/owl/IMR#IMR_0001504
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
Activation of MAPKKKK by Rap1 in cytosol
event
IMR:0100207
http://purl.org/obo/owl/IMR#IMR_0100207
IMR:0001504
http://purl.org/obo/owl/IMR#IMR_0001504
Phosphorylation of MAPKKK by MAPKKKK in cytosol
event
GO:0042655
http://purl.org/obo/owl/GO#GO_0042655
GO:0000185
http://purl.org/obo/owl/GO#GO_0000185
IMR:0000229
http://purl.org/obo/owl/IMR#IMR_0000229
Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase.
GO:0000185
http://purl.org/obo/owl/GO#GO_0000185
activation of MAPKKK activity
activation of MAP kinase kinase kinase
IMR:0100207
http://purl.org/obo/owl/IMR#IMR_0100207
GDP-GTP exchange of Rac by Dock180 in cytosol
event
IMR:0001468
http://purl.org/obo/owl/IMR#IMR_0001468
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0000297
http://purl.org/obo/owl/IMR#IMR_0000297
Complex formation of RhoG, Elmo and Dock180 in cytosol
event
PubMed:12879077
http://purl.org/obo/owl/PubMed#PubMed_12879077
IMR:0001468
http://purl.org/obo/owl/IMR#IMR_0001468
UniProt:P84095
http://purl.org/obo/owl/UniProt#UniProt_P84095
UniProt:Q96JJ3
http://purl.org/obo/owl/UniProt#UniProt_Q96JJ3
UniProt:Q92556
http://purl.org/obo/owl/UniProt#UniProt_Q92556
Binding of PIP2 and gelsolin in cytosol
event
IMR:0001350
http://purl.org/obo/owl/IMR#IMR_0001350
UniProt:P06396
http://purl.org/obo/owl/UniProt#UniProt_P06396
Actin polymerization and/or depolymerization
event
Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
GO:0008154
http://purl.org/obo/owl/GO#GO_0008154
GO:0008154
http://purl.org/obo/owl/GO#GO_0008154
Actin filament depolymerization
event
Actin depolymerization
Disassembly of actin filaments by the removal of actin monomers from a filament.
GO:0030042
http://purl.org/obo/owl/GO#GO_0030042
GO:0030042
http://purl.org/obo/owl/GO#GO_0030042
Actin filament polymerization
event
Actin polymerization
GO:0030041
http://purl.org/obo/owl/GO#GO_0030041
Assembly of actin filaments by the addition of actin monomers to a filament.
GO:0030041
http://purl.org/obo/owl/GO#GO_0030041
Binding of PIP2 and profilin in cytosol
event
IMR:0001350
http://purl.org/obo/owl/IMR#IMR_0001350
IMR:0000194
http://purl.org/obo/owl/IMR#IMR_0000194
Binding of PIP2 and cofilin in cytosol
event
IMR:0001350
http://purl.org/obo/owl/IMR#IMR_0001350
UniProt:P23528
http://purl.org/obo/owl/UniProt#UniProt_P23528
UniProt:Q9Y281
http://purl.org/obo/owl/UniProt#UniProt_Q9Y281
Binding of PIP2 and actinin in cytosol
event
IMR:0001350
http://purl.org/obo/owl/IMR#IMR_0001350
IMR:0000189
http://purl.org/obo/owl/IMR#IMR_0000189
Binding of PIP2 and vinculin in cytosol
event
IMR:0001711
http://purl.org/obo/owl/IMR#IMR_0001711
IMR:0001350
http://purl.org/obo/owl/IMR#IMR_0001350
PubMed:8632828
http://purl.org/obo/owl/PubMed#PubMed_8632828
Binding of vinculin and talin in cytosol
event
PubMed:8632828
http://purl.org/obo/owl/PubMed#PubMed_8632828
IMR:0001711
http://purl.org/obo/owl/IMR#IMR_0001711
IMR:0001714
http://purl.org/obo/owl/IMR#IMR_0001714
Binding of PIP2 and ERM in cytosol
event
IMR:0001350
http://purl.org/obo/owl/IMR#IMR_0001350
IMR:0001093
http://purl.org/obo/owl/IMR#IMR_0001093
Activation of ERM by PIP2 in cytosol
event
PubMed:12045227
http://purl.org/obo/owl/PubMed#PubMed_12045227
PubMed:8858161
http://purl.org/obo/owl/PubMed#PubMed_8858161
IMR:0001093
http://purl.org/obo/owl/IMR#IMR_0001093
IMR:0001350
http://purl.org/obo/owl/IMR#IMR_0001350
Activation of PI5K by Rho in cytosol
event
PubMed:7954816
http://purl.org/obo/owl/PubMed#PubMed_7954816
IMR:0000296
http://purl.org/obo/owl/IMR#IMR_0000296
IMR:0000268
http://purl.org/obo/owl/IMR#IMR_0000268
Y-27632 medication
event
Inhibitor of p160ROCK
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Activation of p160ROCK by Rho in cytosol
event
UniProt:Q13464
http://purl.org/obo/owl/UniProt#UniProt_Q13464
IMR:0000296
http://purl.org/obo/owl/IMR#IMR_0000296
Phosphorylation of myosin phosphatase by p160ROCK in cytosol
event
Inactivation of myosin phosphatase
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
UniProt:Q13464
http://purl.org/obo/owl/UniProt#UniProt_Q13464
PubMed:8662509
http://purl.org/obo/owl/PubMed#PubMed_8662509
Phosphorylation of MLC by MLCK in cytosol
event
UniProt:Q15746
http://purl.org/obo/owl/UniProt#UniProt_Q15746
IMR:0000191
http://purl.org/obo/owl/IMR#IMR_0000191
Phosphorylation of LIM-kinase by p160ROCK in cytosol
event
UniProt:P53667
http://purl.org/obo/owl/UniProt#UniProt_P53667
UniProt:Q13464
http://purl.org/obo/owl/UniProt#UniProt_Q13464
Phosphorylation of cofilin by LIM-kinase in cytosol
event
UniProt:P53667
http://purl.org/obo/owl/UniProt#UniProt_P53667
UniProt:Q9Y281
http://purl.org/obo/owl/UniProt#UniProt_Q9Y281
PubMed:9655398
http://purl.org/obo/owl/PubMed#PubMed_9655398
UniProt:P23528
http://purl.org/obo/owl/UniProt#UniProt_P23528
Phosphorylation of MLCK by ERK in cytosol
event
PubMed:9128257
http://purl.org/obo/owl/PubMed#PubMed_9128257
IMR:0000227
http://purl.org/obo/owl/IMR#IMR_0000227
UniProt:Q15746
http://purl.org/obo/owl/UniProt#UniProt_Q15746
Regulation of Integrin signaling pathway (through Rho)
event
Negative regulation of Integrin signaling pathway (through Rho)
event
Positive regulation of Integrin signaling pathway (through Rho)
event
Phosphorylation of MLCK by PAK in cytosol
event
PubMed:10092231
http://purl.org/obo/owl/PubMed#PubMed_10092231
IMR:0000238
http://purl.org/obo/owl/IMR#IMR_0000238
UniProt:Q15746
http://purl.org/obo/owl/UniProt#UniProt_Q15746
Rac/Cdc42-PAK-MLCK signaling
event
KEGG:rno04810
http://purl.org/obo/owl/KEGG#KEGG_rno04810
KEGG:mmu04810
http://purl.org/obo/owl/KEGG#KEGG_mmu04810
KEGG:hsa04810
http://purl.org/obo/owl/KEGG#KEGG_hsa04810
KEGG:hsa04510
http://purl.org/obo/owl/KEGG#KEGG_hsa04510
Activation of PAK by Cdc42 in cytosol
event
IMR:0000238
http://purl.org/obo/owl/IMR#IMR_0000238
IMR:0000699
http://purl.org/obo/owl/IMR#IMR_0000699
GPCR signaling pathway
event
GO:0007186
http://purl.org/obo/owl/GO#GO_0007186
G-protein coupled receptor protein signaling pathway
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
GO:0007186
http://purl.org/obo/owl/GO#GO_0007186
Binding of GPCR ligand and GPCR in extracellular
event
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
IMR:0000137
http://purl.org/obo/owl/IMR#IMR_0000137
GDP-GTP exchange of G alpha in cytosol
event
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000316
http://purl.org/obo/owl/IMR#IMR_0000316
Dissociation of G alpha-GTP and G beta:G gamma in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0100018
http://purl.org/obo/owl/IMR#IMR_0100018
IMR:0000316
http://purl.org/obo/owl/IMR#IMR_0000316
Dissociation in plasma membrane
event
Binding of G alpha-GTP and effector in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000316
http://purl.org/obo/owl/IMR#IMR_0000316
Binding of G beta:G gamma and effector in cytosol
event
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
IMR:0100018
http://purl.org/obo/owl/IMR#IMR_0100018
Regulation of heterotrimeric GPCR signaling pathway
event
Negative regulation of heterotrimeric GPCR signaling pathway
event
Positive regulation of heterotrimeric GPCR signaling pathway
event
G alpha-GTP hydrolysis signaling
event
Hydrolysis of GTP by G alpha-GTP in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Hydrolysis in unidentified cellular location
event
Binding of G alpha-GTP and RGS in cytosol
event
IMR:0000431
http://purl.org/obo/owl/IMR#IMR_0000431
IMR:0000316
http://purl.org/obo/owl/IMR#IMR_0000316
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Dissociation of G alpha-GDP and target protein in cytosol
event
IMR:0000316
http://purl.org/obo/owl/IMR#IMR_0000316
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
Small GTPase mediated signaling
event
small GTPase mediated signal transduction
GO:0007264
http://purl.org/obo/owl/GO#GO_0007264
GO:0007264
http://purl.org/obo/owl/GO#GO_0007264
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
GO:0007264
http://purl.org/obo/owl/GO#GO_0007264
GDP-GTP exchange of small GTPase by GEF
event
Binding of small GTPase-GTP and target protein
event
Binding of small GTPase-GTP and GAP in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000442
http://purl.org/obo/owl/IMR#IMR_0000442
IMR:0000288
http://purl.org/obo/owl/IMR#IMR_0000288
Hydrolysis of GTP by small GTPase in cytosol
event
IMR:0000288
http://purl.org/obo/owl/IMR#IMR_0000288
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Regulation of small GTPase mediated signaling
event
regulation of small GTPase mediated signal transduction
GO:0051056
http://purl.org/obo/owl/GO#GO_0051056
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
GO:0051056
http://purl.org/obo/owl/GO#GO_0051056
GO:0051056
http://purl.org/obo/owl/GO#GO_0051056
Positive regulation of small GTPase mediated signaling
event
positive regulation of small GTPase mediated signal transduction
GO:0051057
http://purl.org/obo/owl/GO#GO_0051057
Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction.
GO:0051057
http://purl.org/obo/owl/GO#GO_0051057
GO:0051057
http://purl.org/obo/owl/GO#GO_0051057
Negative regulation of small GTPase mediated signaling
event
GO:0051058
http://purl.org/obo/owl/GO#GO_0051058
negative regulation of small GTPase mediated signal transduction
GO:0051058
http://purl.org/obo/owl/GO#GO_0051058
Any process that stops, prevents or reduces the frequency, rate or extent of small GTPase mediated signal transduction.
GO:0051058
http://purl.org/obo/owl/GO#GO_0051058
Small GTPase hydrolysis signaling
event
Hydrolysis in cytosol
event
Binding of G alpha s-GTP and adenylate cyclase in cytosol
Inactivation of ACs.
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000313
http://purl.org/obo/owl/IMR#IMR_0000313
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
IMR:0100366
http://purl.org/obo/owl/IMR#IMR_0100366
Hydrolysis of ATP to cAMP by adenylate cyclase in cytosol
event
The formation from simpler components of cyclic AMP, adenosine 3',5'-phosphate.
GO:0006171
http://purl.org/obo/owl/GO#GO_0006171
IMR:0000313
http://purl.org/obo/owl/IMR#IMR_0000313
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0100024
http://purl.org/obo/owl/IMR#IMR_0100024
PubMed:7814360
http://purl.org/obo/owl/PubMed#PubMed_7814360
GO:0006171
http://purl.org/obo/owl/GO#GO_0006171
Dissociation of G alpha s-GDP and adenylate cyclase in cytosol
event
IMR:0000313
http://purl.org/obo/owl/IMR#IMR_0000313
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0100366
http://purl.org/obo/owl/IMR#IMR_0100366
PubMed:11604548
http://purl.org/obo/owl/PubMed#PubMed_11604548
Binding of G alpha i-GTP and adenylate cyclase in cytosol
event
IMR:0000313
http://purl.org/obo/owl/IMR#IMR_0000313
IMR:0000319
http://purl.org/obo/owl/IMR#IMR_0000319
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
Dissociation of G alpha i-GDP and adenylate cyclase in cytosol
event
IMR:0000319
http://purl.org/obo/owl/IMR#IMR_0000319
IMR:0000313
http://purl.org/obo/owl/IMR#IMR_0000313
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
Heterotrimeric GPCR signaling pathway (through G alpha s)
event
GO:0007189
http://purl.org/obo/owl/GO#GO_0007189
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
Heterotrimeric GPCR signaling pathway (through G alpha i)
event
IEV:0000716
Heterotrimeric GPCR signaling pathway (through G alpha i and pertussis toxin)
Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha s)
event
Negative regulation of (G alpha i GDP-GTP exchange signaling)
event
Positive regulation of heterotrimeric GPCR signaling pathway (through G alpha i)
event
Positive regulation of heterotrimeric GPCR signaling pathway (through G alpha s)
event
Binding of G alpha i-GTP and RGS in cytosol
event
PubMed:8774883
http://purl.org/obo/owl/PubMed#PubMed_8774883
IMR:0000319
http://purl.org/obo/owl/IMR#IMR_0000319
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000431
http://purl.org/obo/owl/IMR#IMR_0000431
Hydrolysis of GTP by G alpha i-GTP and RGS in cytosol
event
PubMed:8774883
http://purl.org/obo/owl/PubMed#PubMed_8774883
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000431
http://purl.org/obo/owl/IMR#IMR_0000431
Binding of G alpha s-GTP and RGS in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000431
http://purl.org/obo/owl/IMR#IMR_0000431
PubMed:11604548
http://purl.org/obo/owl/PubMed#PubMed_11604548
IMR:0100366
http://purl.org/obo/owl/IMR#IMR_0100366
Hydrolysis of GTP by G alpha s-GTP and RGS in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000431
http://purl.org/obo/owl/IMR#IMR_0000431
PubMed:11604548
http://purl.org/obo/owl/PubMed#PubMed_11604548
G alpha i-GTP hydrolysis signaling
event
PubMed:8774883
http://purl.org/obo/owl/PubMed#PubMed_8774883
G alpha s-GTP hydrolysis signaling
event
G alpha s inactivation signaling
PubMed:11604548
http://purl.org/obo/owl/PubMed#PubMed_11604548
Ras-GTP hydrolysis signaling
event
Negative regulation of Ras mediated signaling
event
Any process that stops, prevents or reduces the rate, frequency or extent of Ras protein signal transduction.
GO:0046580
http://purl.org/obo/owl/GO#GO_0046580
negative regulation of Ras protein signal transduction
GO:0046580
http://purl.org/obo/owl/GO#GO_0046580
GO:0046580
http://purl.org/obo/owl/GO#GO_0046580
Hydrolysis of GTP by Ras in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000290
http://purl.org/obo/owl/IMR#IMR_0000290
Binding of Ras-GTP and GAP in cytosol
event
IMR:0000442
http://purl.org/obo/owl/IMR#IMR_0000442
IMR:0000290
http://purl.org/obo/owl/IMR#IMR_0000290
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
event
ADP-ribosylation of G alpha s by cholera toxin in cytosol
event
IMR:0100468
http://purl.org/obo/owl/IMR#IMR_0100468
IMR:0100366
http://purl.org/obo/owl/IMR#IMR_0100366
ADP ribosylation
event
EC:2.4.5.37
http://purl.org/obo/owl/EC#EC_2.4.5.37
Reaction that can affect Arg, Cys, Glu, Arg and Asn residues.
MI:0557
http://purl.org/obo/owl/MI#MI_0557
MI:0557
http://purl.org/obo/owl/MI#MI_0557
EC:2.4.5.30
http://purl.org/obo/owl/EC#EC_2.4.5.30
EC:2.4.5.31
http://purl.org/obo/owl/EC#EC_2.4.5.31
EC:2.4.5.36
http://purl.org/obo/owl/EC#EC_2.4.5.36
ADP ribosylation in cytosol
event
ADP ribosylation in plasma membrane
event
Transference in unidentified cellular location
event
Binding of G alpha s-GTP-ADPrib and adenylate cyclase in cytosol
event
IMR:0100366
http://purl.org/obo/owl/IMR#IMR_0100366
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000313
http://purl.org/obo/owl/IMR#IMR_0000313
Clinical presentation
event
Diarrhea
event
MeSH:D003967
http://purl.org/obo/owl/MeSH#MeSH_D003967
An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
MeSH:D003967
http://purl.org/obo/owl/MeSH#MeSH_D003967
Whooping cough
event
A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath.
MeSH:D014917
http://purl.org/obo/owl/MeSH#MeSH_D014917
MeSH:D014917
http://purl.org/obo/owl/MeSH#MeSH_D014917
ADP ribosylation of G alpha i by pertussis toxin in cytosol
event
PubMed:9032437
http://purl.org/obo/owl/PubMed#PubMed_9032437
IMR:0000319
http://purl.org/obo/owl/IMR#IMR_0000319
IMR:0100469
http://purl.org/obo/owl/IMR#IMR_0100469
Dissociation of G alpha i-GTP and G beta:G gamma in cytosol
event
IMR:0000319
http://purl.org/obo/owl/IMR#IMR_0000319
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0100018
http://purl.org/obo/owl/IMR#IMR_0100018
GDP-GTP exchange of G alpha i in cytosol
event
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000319
http://purl.org/obo/owl/IMR#IMR_0000319
Dissociation of G alpha s-GTP and G beta:G gamma in cytosol
event
IMR:0100366
http://purl.org/obo/owl/IMR#IMR_0100366
IMR:0100018
http://purl.org/obo/owl/IMR#IMR_0100018
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
GDP-GTP exchange of G alpha s in cytosol
event
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
IMR:0000317
http://purl.org/obo/owl/IMR#IMR_0000317
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)
event
GO:0030265
http://purl.org/obo/owl/GO#GO_0030265
The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon.
GO:0016056
http://purl.org/obo/owl/GO#GO_0016056
Activation of rhodopsin by photon in extracellular
event
UniProt:P08100
http://purl.org/obo/owl/UniProt#UniProt_P08100
Activation in extracellular
event
GDP-GTP exchange of G alpha t in cytosol
event
IMR:0000321
http://purl.org/obo/owl/IMR#IMR_0000321
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
Dissociation of G alpha t-GTP and G beta:G gamma in cytosol
event
IMR:0000321
http://purl.org/obo/owl/IMR#IMR_0000321
IMR:0100018
http://purl.org/obo/owl/IMR#IMR_0100018
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Binding of G alpha t-GTP and cGMP PDE in cytosol
event
IMR:0000321
http://purl.org/obo/owl/IMR#IMR_0000321
IMR:0001022
http://purl.org/obo/owl/IMR#IMR_0001022
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Hydrolysis of cGMP to GMP by cGMP PDE in cytosol
event
IMR:0001022
http://purl.org/obo/owl/IMR#IMR_0001022
IMR:0200292
http://purl.org/obo/owl/IMR#IMR_0200292
IMR:0100025
http://purl.org/obo/owl/IMR#IMR_0100025
Regulation of heterotrimeric GPCR signaling pathway (through G alpha i)
event
Regulation of heterotrimeric GPCR signaling pathway (through G alpha s)
event
Regulation of heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and PDE)
event
Negative regulation of heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and PDE)
event
Positive regulation of heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and PDE)
event
G alpha t-GTP hydrolysis signaling
event
Binding of G alpha t-GTP and RGS in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000431
http://purl.org/obo/owl/IMR#IMR_0000431
IMR:0000321
http://purl.org/obo/owl/IMR#IMR_0000321
Dissociation of G alpha t-GDP and cGMP PDE in cytosol
event
IMR:0001022
http://purl.org/obo/owl/IMR#IMR_0001022
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0000321
http://purl.org/obo/owl/IMR#IMR_0000321
Hydrolysis of GTP by G alpha t-GTP and RGS in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000431
http://purl.org/obo/owl/IMR#IMR_0000431
Ion transport through ion channel
event
ion transport
The directed movement of charged atoms or small charged molecules into, out of, within or between cells.
GO:0006811
http://purl.org/obo/owl/GO#GO_0006811
GO:0006811
http://purl.org/obo/owl/GO#GO_0006811
Cation ion transport from extracellular to cytosol through cation channel
event
IMR:0001658
http://purl.org/obo/owl/IMR#IMR_0001658
IMR:0000498
http://purl.org/obo/owl/IMR#IMR_0000498
GDP-GTP exchange of G alpha q in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0100378
http://purl.org/obo/owl/IMR#IMR_0100378
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
Visual perception
event
GO:0007601
http://purl.org/obo/owl/GO#GO_0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
GO:0007601
http://purl.org/obo/owl/GO#GO_0007601
Changes in polarization state of photoreceptor cell membrane
event
Neurological system process
event
The processes pertaining to the functions of the nervous system of an organism.
GO:0050877
http://purl.org/obo/owl/GO#GO_0050877
Neurophysiological process
GO:0050877
http://purl.org/obo/owl/GO#GO_0050877
Neurological process
GO:0050877
http://purl.org/obo/owl/GO#GO_0050877
Neurotransmitter secretion
event
The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
GO:0007269
http://purl.org/obo/owl/GO#GO_0007269
GO:0007269
http://purl.org/obo/owl/GO#GO_0007269
neurotransmitter release
Adaptation of rhodopsin mediated signaling
event
Process by which the visual system can modulate its sensitivity and response to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation.
GO:0016062
http://purl.org/obo/owl/GO#GO_0016062
GO:0016062
http://purl.org/obo/owl/GO#GO_0016062
Deactivation of rhodopsin mediated signaling
event
The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon).
GO:0016059
http://purl.org/obo/owl/GO#GO_0016059
GO:0016059
http://purl.org/obo/owl/GO#GO_0016059
Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
event
GO:0007200
http://purl.org/obo/owl/GO#GO_0007200
Dissociation of G alpha q-GTP and G beta:G gamma in cytosol
event
IMR:0100018
http://purl.org/obo/owl/IMR#IMR_0100018
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0100378
http://purl.org/obo/owl/IMR#IMR_0100378
GO:0007201
http://purl.org/obo/owl/GO#GO_0007201
Binding of G alpha q-GTP and PLC beta in cytosol
event
IMR:0000286
http://purl.org/obo/owl/IMR#IMR_0000286
IMR:0100378
http://purl.org/obo/owl/IMR#IMR_0100378
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
Regulation of heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
event
Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
event
Positive regulation of heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
event
G alpha q-GTP hydrolysis signaling
event
Binding of G alpha q-GTP and RGS in cytosol
event
IMR:0000431
http://purl.org/obo/owl/IMR#IMR_0000431
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0100378
http://purl.org/obo/owl/IMR#IMR_0100378
Dissociation of G alpha q-GDP and PLC beta in cytosol
event
IMR:0100378
http://purl.org/obo/owl/IMR#IMR_0100378
IMR:0000286
http://purl.org/obo/owl/IMR#IMR_0000286
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
Hydrolysis of GTP by G alpha q-GTP and RGS in cytosol
event
IMR:0000431
http://purl.org/obo/owl/IMR#IMR_0000431
IMR:0100378
http://purl.org/obo/owl/IMR#IMR_0100378
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Rhodopsin dark adaptation
event
Rhodopsin dark adaptation signaling
event
Inactivation of Rhodopsin in extracellular
event
UniProt:P08100
http://purl.org/obo/owl/UniProt#UniProt_P08100
Nuclear import of Notch (NIC) from the cytosol
event
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
Channel opening/closing in the plasma membrane
event
Binding of cGMP and cGMP activated cation ion channel and the channel opening in cytosol
event
IMR:0100025
http://purl.org/obo/owl/IMR#IMR_0100025
IMR:0100003
http://purl.org/obo/owl/IMR#IMR_0100003
Dissociation of cGMP and cGMP activated cation ion channel and the channel closing in cytosol
event
IMR:0100025
http://purl.org/obo/owl/IMR#IMR_0100025
IMR:0100003
http://purl.org/obo/owl/IMR#IMR_0100003
Dissociation of IP3 and IP3R and IP3R closing
event
IMR:0100028
http://purl.org/obo/owl/IMR#IMR_0100028
IMR:0000084
http://purl.org/obo/owl/IMR#IMR_0000084
Binding of G alpha t-GDP and G beta:G gamma in cytosol
event
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0000321
http://purl.org/obo/owl/IMR#IMR_0000321
IMR:0100018
http://purl.org/obo/owl/IMR#IMR_0100018
Channel opening/closing
event
Hyper polarization state of photoreceptor cell membrane
event
Depolarization state of photoreceptor cell membrane
event
Channel opening/closing in the ER membrane
event
Change in material concentration
event
Cytosolic calcium ion concentration elevation (through IP3 receptor)
event
elevation of cytosolic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)
elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
Any process that increases the concentration of calcium ions in the cytosol during the process of G-protein signaling coupled to IP3 second messenger.
GO:0051482
http://purl.org/obo/owl/GO#GO_0051482
GO:0051482
http://purl.org/obo/owl/GO#GO_0051482
Heterotrimeric GPCR signaling pathway (through melatonin, G alpha o and PLCbeta)
event
Circadian rhythm
event
IEV:0001334
Circadian process
Response to circadian rhythm
KEGG:rno04710
http://purl.org/obo/owl/KEGG#KEGG_rno04710
GO:0007623
http://purl.org/obo/owl/GO#GO_0007623
KEGG:hsa04710
http://purl.org/obo/owl/KEGG#KEGG_hsa04710
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
GO:0007623
http://purl.org/obo/owl/GO#GO_0007623
KEGG:mmu04710
http://purl.org/obo/owl/KEGG#KEGG_mmu04710
Binding of melatonin and melatonin receptor in cytosol
part_of: Heterotrimeric GPCR signaling pathway (through melatonin, G alpha o, PLCbeta and circadian rhythm)
event
UniProt:P48039
http://purl.org/obo/owl/UniProt#UniProt_P48039
UniProt:P49286
http://purl.org/obo/owl/UniProt#UniProt_P49286
GO:0008502
http://purl.org/obo/owl/GO#GO_0008502
IMR:0100069
http://purl.org/obo/owl/IMR#IMR_0100069
GO:0001664
http://purl.org/obo/owl/GO#GO_0001664
GDP-GTP exchange of G alpha o in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000320
http://purl.org/obo/owl/IMR#IMR_0000320
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
Dissociation of G alpha o-GTP and G beta:G gamma in cytosol
event
IMR:0000320
http://purl.org/obo/owl/IMR#IMR_0000320
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0100018
http://purl.org/obo/owl/IMR#IMR_0100018
Binding of G alpha o-GTP and PLC beta in cytosol
event
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
IMR:0000286
http://purl.org/obo/owl/IMR#IMR_0000286
IMR:0000320
http://purl.org/obo/owl/IMR#IMR_0000320
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
PKC activation signaling
event
PKC activation
GO:0007205
http://purl.org/obo/owl/GO#GO_0007205
protein kinase C activation
GO:0007205
http://purl.org/obo/owl/GO#GO_0007205
GO:0007205
http://purl.org/obo/owl/GO#GO_0007205
The series of molecular signals that results in the upregulation of protein kinase C activity in response to the signal.
GO:0007205
http://purl.org/obo/owl/GO#GO_0007205
PKA activation signaling
event
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
Phosphorylation of IKK complex by MEKK3 in cytosol
event
IMR:0000243
http://purl.org/obo/owl/IMR#IMR_0000243
TNFR1 signaling
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
GO:0007250
http://purl.org/obo/owl/GO#GO_0007250
IMR:0100451
http://purl.org/obo/owl/IMR#IMR_0100451
Gene expression by NF-kappaB
event
IMR:0000382
http://purl.org/obo/owl/IMR#IMR_0000382
Phosphorylation of IKK complex by TAK1 in cytosol
event
IMR:0000232
http://purl.org/obo/owl/IMR#IMR_0000232
PubMed:15125833
http://purl.org/obo/owl/PubMed#PubMed_15125833
IMR:0000243
http://purl.org/obo/owl/IMR#IMR_0000243
Phosphorylation of DmIKK by TAK1 [Drosophila]
Toll-like receptor pathway
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Regulation of Toll-like receptor pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
event
Negative regulation of Toll-like receptor pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
event
Positive regulation of Toll-like receptor pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK- NF-kappaB cascade)
event
Binding of RelA and PPAR in inner space of nucleus
event
IMR:0100446
http://purl.org/obo/owl/IMR#IMR_0100446
IMR:0000089
http://purl.org/obo/owl/IMR#IMR_0000089
PubMed:14587029
http://purl.org/obo/owl/PubMed#PubMed_14587029
PPAR signaling
event
KEGG:hsa03320
http://purl.org/obo/owl/KEGG#KEGG_hsa03320
peroxisome proliferator-activated receptor signaling
Binding of ligand and PPAR in cytosol
event
IMR:0000089
http://purl.org/obo/owl/IMR#IMR_0000089
IMR:0000002
http://purl.org/obo/owl/IMR#IMR_0000002
Binding outside the nuclear membrane
event
Binding of PPAR and nuclear receptor in inner space of nucleus
event
IMR:0000089
http://purl.org/obo/owl/IMR#IMR_0000089
IMR:0000085
http://purl.org/obo/owl/IMR#IMR_0000085
Binding of PPAR and PPRE in inner space of nucleus
event
IGS:0000015
http://purl.org/obo/owl/IGS#IGS_0000015
IMR:0000089
http://purl.org/obo/owl/IMR#IMR_0000089
Binding of fatty acid and PPAR in cytosol
event
KEGG:C00162
http://purl.org/obo/owl/KEGG#KEGG_C00162
IMR:0000089
http://purl.org/obo/owl/IMR#IMR_0000089
Binding of PPAR and transcription factor in inner space of nucleus
event
IMR:0000089
http://purl.org/obo/owl/IMR#IMR_0000089
IMR:0000368
http://purl.org/obo/owl/IMR#IMR_0000368
Binding of PPAR and RXR in inner space of nucleus
event
UniProt:P19793
http://purl.org/obo/owl/UniProt#UniProt_P19793
UniProt:P28702
http://purl.org/obo/owl/UniProt#UniProt_P28702
IMR:0000089
http://purl.org/obo/owl/IMR#IMR_0000089
Phosphorylation of PPAR by kinase in cytosol
event
IMR:0000089
http://purl.org/obo/owl/IMR#IMR_0000089
Regulation of PPAR signaling
event
Negative regulation of PPAR signaling
event
Positive regulation of PPAR signaling
event
Dephosphorylation of PPAR by phosphatase in cytosol
event
IMR:0000089
http://purl.org/obo/owl/IMR#IMR_0000089
IMR:0000517
http://purl.org/obo/owl/IMR#IMR_0000517
TNFR2 signaling pathway (through IKK-NF-kappaB cascade)
event
Trimerization of TNFR2 in plasma membrane
event
IMR:0000061
http://purl.org/obo/owl/IMR#IMR_0000061
TNFR2 trimerization
Binding of TNF alpha homotrimer and TNFR2 in extracellular
event
IMR:0000025
http://purl.org/obo/owl/IMR#IMR_0000025
IMR:0000061
http://purl.org/obo/owl/IMR#IMR_0000061
Binding of TNFR2 and TRAF2 in cytosol
event
IMR:0000061
http://purl.org/obo/owl/IMR#IMR_0000061
IMR:0100423
http://purl.org/obo/owl/IMR#IMR_0100423
Binding of TNFR2 and TRAF1 in cytosol
event
IMR:0000061
http://purl.org/obo/owl/IMR#IMR_0000061
IMR:0100422
http://purl.org/obo/owl/IMR#IMR_0100422
Activation of MEKK1 by RIP in cytosol
event
IMR:0100222
http://purl.org/obo/owl/IMR#IMR_0100222
IMR:0000269
http://purl.org/obo/owl/IMR#IMR_0000269
Activation of NIK by RIP in cytosol
event
IMR:0000269
http://purl.org/obo/owl/IMR#IMR_0000269
IMR:0000242
http://purl.org/obo/owl/IMR#IMR_0000242
Phosphorylation of MEKK1 by NIK in cytosol
event
IMR:0000242
http://purl.org/obo/owl/IMR#IMR_0000242
IMR:0100222
http://purl.org/obo/owl/IMR#IMR_0100222
Phosphorylation of IKK complex by MEKK1 in cytosol
event
IMR:0100222
http://purl.org/obo/owl/IMR#IMR_0100222
GO:0007250
http://purl.org/obo/owl/GO#GO_0007250
IMR:0000243
http://purl.org/obo/owl/IMR#IMR_0000243
Phosphorylation of MKK4/7 by ASK1 in cytosol
event
GO:0007256
http://purl.org/obo/owl/GO#GO_0007256
TNFR1 signaling
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
IMR:0100218
http://purl.org/obo/owl/IMR#IMR_0100218
IMR:0000262
http://purl.org/obo/owl/IMR#IMR_0000262
Binding of PDGF and PDGF receptor in extracellular
event
IMR:0000068
http://purl.org/obo/owl/IMR#IMR_0000068
IMR:0000032
http://purl.org/obo/owl/IMR#IMR_0000032
Dimerization of PDGF receptor in plasma membrane
event
PDGF receptor dimerization
IMR:0000068
http://purl.org/obo/owl/IMR#IMR_0000068
Autophosphorylation of PDGF receptor in plasma membrane
event
IMR:0000068
http://purl.org/obo/owl/IMR#IMR_0000068
Binding of PDGF receptor and Grb2 in cytosol
IEV:0002452
event
Binding of (PDGF:PDGF Receptor_p) and (GRB2:SOS)
IMR:0000340
http://purl.org/obo/owl/IMR#IMR_0000340
IMR:0000068
http://purl.org/obo/owl/IMR#IMR_0000068
Binding of PDGF receptor and Shc in cytosol
event
IMR:0000068
http://purl.org/obo/owl/IMR#IMR_0000068
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
Transcription of c-fos by Elk-1 in nucleus
event
IMR:0001094
http://purl.org/obo/owl/IMR#IMR_0001094
IMR:0000813
http://purl.org/obo/owl/IMR#IMR_0000813
Metabolic pathway
event
Phosphorylation of Elk-1 by ERK_p in inner space of nucleus
event
PDGF signaling
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
IMR:0000227
http://purl.org/obo/owl/IMR#IMR_0000227
IMR:0001094
http://purl.org/obo/owl/IMR#IMR_0001094
Phosphorylation of MEK1/2(MKK1/2) by Raf in cytosol
event
PDGF signaling, Integrin signaling, G
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
PubMed:11752597
http://purl.org/obo/owl/PubMed#PubMed_11752597
IMR:0000261
http://purl.org/obo/owl/IMR#IMR_0000261
IMR:0000231
http://purl.org/obo/owl/IMR#IMR_0000231
Regulation of PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
event
Negative regulation of PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
event
Positive regulation of PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
event
Dissociation of Ras-GDP and target protein in cytosol
event
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0000290
http://purl.org/obo/owl/IMR#IMR_0000290
PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
event
RalGDS-Ral-RalBP1 signaling
event
Binding of Ras-GTP and RalGDS in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0100433
http://purl.org/obo/owl/IMR#IMR_0100433
IMR:0000290
http://purl.org/obo/owl/IMR#IMR_0000290
GDP-GTP exchange of Ral by RalGDS in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0000293
http://purl.org/obo/owl/IMR#IMR_0000293
IMR:0100433
http://purl.org/obo/owl/IMR#IMR_0100433
Binding of Ral-GTP and RalBP1 in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
UniProt:Q15311
http://purl.org/obo/owl/UniProt#UniProt_Q15311
Activation of RalBP1 by Ral-GTP
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
IMR:0000293
http://purl.org/obo/owl/IMR#IMR_0000293
RTK signaling pathway
event
GO:0007169
http://purl.org/obo/owl/GO#GO_0007169
The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand.
GO:0007169
http://purl.org/obo/owl/GO#GO_0007169
transmembrane receptor protein tyrosine kinase signaling pathway
Complex formation of PI3K, Eps8, Abi1 and Sos1 in cytosol
event
IMR:0000265
http://purl.org/obo/owl/IMR#IMR_0000265
IMR:0002063
http://purl.org/obo/owl/IMR#IMR_0002063
PubMed:12515821
http://purl.org/obo/owl/PubMed#PubMed_12515821
UniProt:Q12929
http://purl.org/obo/owl/UniProt#UniProt_Q12929
UniProt:Q8IZP0
http://purl.org/obo/owl/UniProt#UniProt_Q8IZP0
GDP-GTP exchange of Rac by Sos1 in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000297
http://purl.org/obo/owl/IMR#IMR_0000297
PubMed:12515821
http://purl.org/obo/owl/PubMed#PubMed_12515821
IMR:0002063
http://purl.org/obo/owl/IMR#IMR_0002063
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
Rac activation signaling (through PI3K)
event
PubMed:12515821
http://purl.org/obo/owl/PubMed#PubMed_12515821
Regulation of RTK signaling pathway
event
Negative regulation of RTK signaling pathway
event
Positive regulation of RTK signaling pathway
event
Activation of NF-kappaB by Rac-GTP in cytosol
event
NF-kappaB activation
IMR:0000297
http://purl.org/obo/owl/IMR#IMR_0000297
IMR:0000382
http://purl.org/obo/owl/IMR#IMR_0000382
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
PubMed:10740269
http://purl.org/obo/owl/PubMed#PubMed_10740269
Gene expression of anti-apoptotic gene by NF-kappaB
event
IMR:0000382
http://purl.org/obo/owl/IMR#IMR_0000382
Regulation of PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
event
Negative regulation of PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
event
Positive regulation of PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
event
Binding of RTK-ligand and RTK in extracellular
event
IMR:0000063
http://purl.org/obo/owl/IMR#IMR_0000063
IMR:0000030
http://purl.org/obo/owl/IMR#IMR_0000030
Autophosphorylation of RTK in plasma membrane
event
GO:0004714
http://purl.org/obo/owl/GO#GO_0004714
IMR:0000063
http://purl.org/obo/owl/IMR#IMR_0000063
Binding of RTK and Grb2 in cytosol
event
IMR:0000340
http://purl.org/obo/owl/IMR#IMR_0000340
IMR:0000063
http://purl.org/obo/owl/IMR#IMR_0000063
Binding of RTK and Shc in cytosol
event
IMR:0000063
http://purl.org/obo/owl/IMR#IMR_0000063
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
Dimerization of RTK in plasma membrane
event
IMR:0000063
http://purl.org/obo/owl/IMR#IMR_0000063
GO:0007171
http://purl.org/obo/owl/GO#GO_0007171
transmembrane receptor protein tyrosine kinase activation (dimerization)
RTK dimerization
RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
event
RalGDS activation signaling (through Grb2 and Sos)
event
Grb2-Sos-Ras-RalGDS signaling
Activation of RalGDS by Ras-GTP in cytosol
event
IMR:0100433
http://purl.org/obo/owl/IMR#IMR_0100433
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000290
http://purl.org/obo/owl/IMR#IMR_0000290
Rac-GTP hydrolysis signaling
event
Hydrolysis of GTP by Rac in cytosol
event
IMR:0000297
http://purl.org/obo/owl/IMR#IMR_0000297
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Dissociation of Rac-GDP and target protein in cytosol
event
IMR:0000297
http://purl.org/obo/owl/IMR#IMR_0000297
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
Regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
event
Negative regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
event
Positive regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
event
RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)
event
RalGDS-Ral-PLD1 signaling
event
Binding of Ral-GTP and Phospholipase D1 in cytosol
event
IMR:0000728
http://purl.org/obo/owl/IMR#IMR_0000728
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000293
http://purl.org/obo/owl/IMR#IMR_0000293
Hydrolysis of phosphatidic acid by PLD1 in cytosol
event
IMR:0000728
http://purl.org/obo/owl/IMR#IMR_0000728
KEGG:C00416
http://purl.org/obo/owl/KEGG#KEGG_C00416
Regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)
event
Negative regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)
event
Positive regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)
event
BMP signaling pathway
event
GO:0030509
http://purl.org/obo/owl/GO#GO_0030509
BMP receptor signaling pathway
GO:0030509
http://purl.org/obo/owl/GO#GO_0030509
A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor.
GO:0030509
http://purl.org/obo/owl/GO#GO_0030509
TGF beta signaling pathway
event
The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands.
GO:0007179
http://purl.org/obo/owl/GO#GO_0007179
transforming growth factor beta receptor signaling pathway
GO:0007179
http://purl.org/obo/owl/GO#GO_0007179
GO:0007179
http://purl.org/obo/owl/GO#GO_0007179
KEGG:hsa04350
http://purl.org/obo/owl/KEGG#KEGG_hsa04350
EGF receptor signaling pathway
event
The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands.
GO:0007173
http://purl.org/obo/owl/GO#GO_0007173
epidermal growth factor receptor signaling pathway
GO:0007173
http://purl.org/obo/owl/GO#GO_0007173
EGFR signaling pathway
GO:0007173
http://purl.org/obo/owl/GO#GO_0007173
EGF signaling pathway
GO:0007173
http://purl.org/obo/owl/GO#GO_0007173
GO:0007173
http://purl.org/obo/owl/GO#GO_0007173
NGF receptor signaling pathway
event
KEGG:rno04210
http://purl.org/obo/owl/KEGG#KEGG_rno04210
KEGG:mmu04210
http://purl.org/obo/owl/KEGG#KEGG_mmu04210
The series of molecular signals generated as a consequence of the nerve growth factor receptor binding to one of its physiological ligands.
GO:0048011
http://purl.org/obo/owl/GO#GO_0048011
KEGG:hsa04210
http://purl.org/obo/owl/KEGG#KEGG_hsa04210
nerve growth factor receptor signaling pathway
GO:0048011
http://purl.org/obo/owl/GO#GO_0048011
NGF signaling pathway
GO:0048011
http://purl.org/obo/owl/GO#GO_0048011
GO:0048011
http://purl.org/obo/owl/GO#GO_0048011
EPO signaling pathway
event
p53 degradation signaling
event
PubMed:10721693
http://purl.org/obo/owl/PubMed#PubMed_10721693
Ubiquitination of p53 by Mdm2 in nucleus
event
PubMed:15021897
http://purl.org/obo/owl/PubMed#PubMed_15021897
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
IMR:0100660
http://purl.org/obo/owl/IMR#IMR_0100660
PubMed:10721693
http://purl.org/obo/owl/PubMed#PubMed_10721693
Binding of Mdm2 and p19ARF in inner space of nucleus
event
PubMed:15021897
http://purl.org/obo/owl/PubMed#PubMed_15021897
IMR:0100660
http://purl.org/obo/owl/IMR#IMR_0100660
IMR:0701010
http://purl.org/obo/owl/IMR#IMR_0701010
Ubiquitination in nucleus
event
DNA repair
event
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
GO:0006281
http://purl.org/obo/owl/GO#GO_0006281
GO:0006281
http://purl.org/obo/owl/GO#GO_0006281
MeSH:D004260
http://purl.org/obo/owl/MeSH#MeSH_D004260
Regulation of TGF beta signaling pathway
event
Any process that modulates the frequency, rate or extent of activity of any TGFbeta receptor signaling pathway.
GO:0017015
http://purl.org/obo/owl/GO#GO_0017015
GO:0017015
http://purl.org/obo/owl/GO#GO_0017015
Negative regulation of TGF beta signaling pathway
event
GO:0030512
http://purl.org/obo/owl/GO#GO_0030512
Any process that stops, prevents or reduces the rate, frequency or extent of any TGFbeta receptor signaling pathway.
GO:0030512
http://purl.org/obo/owl/GO#GO_0030512
Positive regulation of TGF beta signaling pathway
event
Any process that activates or increases the rate, frequency or extent of TGFbeta receptor signaling pathway activity.
GO:0030511
http://purl.org/obo/owl/GO#GO_0030511
GO:0030511
http://purl.org/obo/owl/GO#GO_0030511
Regulation of TGF beta super family signaling pathway (through p38 cascade)
event
Negative regulation of TGF beta super family signaling pathway (through p38 cascade)
event
Positive regulation of TGF beta super family signaling pathway (through p38 cascade)
event
Regulation of TGF beta super family signaling pathway
event
Negative regulation of TGF beta super family signaling pathway
event
Positive regulation of TGF beta super family signaling pathway
event
Regulation of BMP signaling pathway
event
GO:0030510
http://purl.org/obo/owl/GO#GO_0030510
Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.
GO:0030510
http://purl.org/obo/owl/GO#GO_0030510
Negative regulation of BMP signaling pathway
event
Any process that stops, prevents or reduces the rate, frequency or extent of BMP signaling pathway activity.
GO:0030514
http://purl.org/obo/owl/GO#GO_0030514
GO:0030514
http://purl.org/obo/owl/GO#GO_0030514
Positive regulation of BMP signaling pathway
event
GO:0030513
http://purl.org/obo/owl/GO#GO_0030513
Any process that activates or increases the rate, frequency or extent of BMP signaling pathway activity.
GO:0030513
http://purl.org/obo/owl/GO#GO_0030513
Negative feedback regulation pathway of TGF beta superfamily signaling
event
Negative feedback regulation pathway of TGF beta superfamily signaling pathway
Gene expression of I-Smad by R-Smad:Smad4
event
Gene expression of Smad6/7 by R-Smad:Smad4
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
IMR:0000373
http://purl.org/obo/owl/IMR#IMR_0000373
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
Binding of I-Smad and TGF beta receptor I in cytosol
event
Binding of Smad6/7 and TGF beta receptor I in cytosol
IMR:0000373
http://purl.org/obo/owl/IMR#IMR_0000373
IMR:0000710
http://purl.org/obo/owl/IMR#IMR_0000710
Phosphorylation of R-Smad:Smad4 by MAPK in cytosol
event
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
IMR:0000224
http://purl.org/obo/owl/IMR#IMR_0000224
PubMed:11752591
http://purl.org/obo/owl/PubMed#PubMed_11752591
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
TGF beta receptor I degradation signaling
event
PubMed:11163210
http://purl.org/obo/owl/PubMed#PubMed_11163210
Complex formation of Smad7 and smurf2 in cytosol
event
IMR:0100318
http://purl.org/obo/owl/IMR#IMR_0100318
PubMed:11163210
http://purl.org/obo/owl/PubMed#PubMed_11163210
IMR:0100514
http://purl.org/obo/owl/IMR#IMR_0100514
Binding of Smad7:smurf2 and TGF beta type I receptor in cytosol
event
IMR:0100318
http://purl.org/obo/owl/IMR#IMR_0100318
IMR:0000710
http://purl.org/obo/owl/IMR#IMR_0000710
PubMed:11163210
http://purl.org/obo/owl/PubMed#PubMed_11163210
IMR:0100514
http://purl.org/obo/owl/IMR#IMR_0100514
Ubiquitination of TGF beta receptor I by smurf2 in cytosol
event
IMR:0100514
http://purl.org/obo/owl/IMR#IMR_0100514
IMR:0000710
http://purl.org/obo/owl/IMR#IMR_0000710
PubMed:11163210
http://purl.org/obo/owl/PubMed#PubMed_11163210
Proteasome degradation of TGF beta receptor I by 26S proteasome in plasma membrane
event
PubMed:11163210
http://purl.org/obo/owl/PubMed#PubMed_11163210
IMR:0000310
http://purl.org/obo/owl/IMR#IMR_0000310
IMR:0000710
http://purl.org/obo/owl/IMR#IMR_0000710
Dissociation of Smad7:smurf2 and TGF beta receptor I_Ub in cytosol
event
IMR:0100514
http://purl.org/obo/owl/IMR#IMR_0100514
IMR:0100318
http://purl.org/obo/owl/IMR#IMR_0100318
IMR:0000710
http://purl.org/obo/owl/IMR#IMR_0000710
PubMed:11163210
http://purl.org/obo/owl/PubMed#PubMed_11163210
R-Smad degradation signaling
event
GO:0030579
http://purl.org/obo/owl/GO#GO_0030579
ubiquitin-dependent SMAD protein breakdown
ubiquitin-dependent SMAD protein catabolic process
ubiquitin-dependent SMAD protein catabolism
The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome.
GO:0030579
http://purl.org/obo/owl/GO#GO_0030579
ubiquitin-dependent SMAD protein degradation
Binding of Smad7:smurf1/2 and R-Smad in cytosol
event
IMR:0100514
http://purl.org/obo/owl/IMR#IMR_0100514
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
IMR:0100513
http://purl.org/obo/owl/IMR#IMR_0100513
IMR:0100318
http://purl.org/obo/owl/IMR#IMR_0100318
Ubiquitination of R-Smad_Ub by smurf1/2 in cytosol
event
IMR:0100513
http://purl.org/obo/owl/IMR#IMR_0100513
IMR:0100514
http://purl.org/obo/owl/IMR#IMR_0100514
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
Dissociation of Smad7:smurf1/2 and R-Smad_Ub in cytosol
event
IMR:0100318
http://purl.org/obo/owl/IMR#IMR_0100318
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
IMR:0100514
http://purl.org/obo/owl/IMR#IMR_0100514
IMR:0100513
http://purl.org/obo/owl/IMR#IMR_0100513
Proteasome degradation of R-Smad by 26S proteasome in cytosol
event
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
IMR:0000310
http://purl.org/obo/owl/IMR#IMR_0000310
Nuclear export of mRNA (I-Smad)
event
IMR:0000373
http://purl.org/obo/owl/IMR#IMR_0000373
Nuclear export of mRNA (Smad6/7)
Transcription of I-Smad by R-Smad:Smad4 in nucleus
event
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
IMR:0000373
http://purl.org/obo/owl/IMR#IMR_0000373
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
Transcription of Smad6/7 by R-Smad:Smad4 in nucleus
Translation of I-Smad in cytosol
event
IMR:0000373
http://purl.org/obo/owl/IMR#IMR_0000373
Translation of Smad6/7 in cytosol
Negative feedback regulation pathway of TGF beta superfamily signaling by (binding of I-Smad and TGF beta receptor I)
event
IMR:0000373
http://purl.org/obo/owl/IMR#IMR_0000373
Negative feedback regulation pathway of TGF beta superfamily signaling by (binding of Smad6/7 and TGF beta receptor I)
IMR:0000093
http://purl.org/obo/owl/IMR#IMR_0000093
Negative feedback regulation pathway of TGF beta superfamily signaling by (R-Smad degradation through smurf1/2)
event
IMR:0100514
http://purl.org/obo/owl/IMR#IMR_0100514
IMR:0100513
http://purl.org/obo/owl/IMR#IMR_0100513
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
Negative feedback regulation pathway of TGF beta superfamily signaling by (TGF receptor degradation by smurf)
event
IMR:0000094
http://purl.org/obo/owl/IMR#IMR_0000094
IMR:0000093
http://purl.org/obo/owl/IMR#IMR_0000093
Gene expression of Smad7 by R-Smad:Smad4
event
IMR:0100318
http://purl.org/obo/owl/IMR#IMR_0100318
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
Transcription of Smad7 by R-Smad:Smad4 in nucleus
event
IMR:0100318
http://purl.org/obo/owl/IMR#IMR_0100318
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
Translation of Smad7 in cytosol
event
IMR:0100318
http://purl.org/obo/owl/IMR#IMR_0100318
Nuclear export of mRNA
event
GO:0006406
http://purl.org/obo/owl/GO#GO_0006406
mRNA export out of nucleus
mRNA export from nucleus
The directed movement of mRNA from the nucleus to the cytoplasm.
GO:0006406
http://purl.org/obo/owl/GO#GO_0006406
mRNA transport from nucleus to cytoplasm
mRNA-nucleus export
DR4/5 signaling pathway
event
REACT:402.1
http://purl.org/obo/owl/REACT#REACT_402.1
TRAIL signaling
DR3 signaling pathway
event
Ligation
event
EC:6 catalyzed process
EC:6.-.-.-
http://purl.org/obo/owl/EC#EC_6.-.-.-
EC:6.-.-.-
http://purl.org/obo/owl/EC#EC_6.-.-.-
GO:0016874
http://purl.org/obo/owl/GO#GO_0016874
Transference
event
GO:0016740
http://purl.org/obo/owl/GO#GO_0016740
EC:2 catalyzed process
EC:2.-.-.-
http://purl.org/obo/owl/EC#EC_2.-.-.-
EC:2.-.-.-
http://purl.org/obo/owl/EC#EC_2.-.-.-
Oxidation/Reduction
event
EC:1 catalyzed process
EC:1.-.-.-
http://purl.org/obo/owl/EC#EC_1.-.-.-
EC:1.-.-.-
http://purl.org/obo/owl/EC#EC_1.-.-.-
GO:0016491
http://purl.org/obo/owl/GO#GO_0016491
Isomerization
event
EC:5.-.-.-
http://purl.org/obo/owl/EC#EC_5.-.-.-
GO:0016853
http://purl.org/obo/owl/GO#GO_0016853
EC:5 catalyzed process
EC:5.-.-.-
http://purl.org/obo/owl/EC#EC_5.-.-.-
Reduction
event
Lyase process
event
EC:4.-.-.-
http://purl.org/obo/owl/EC#EC_4.-.-.-
GO:0016829
http://purl.org/obo/owl/GO#GO_0016829
STKE:0456
http://purl.org/obo/owl/STKE#STKE_0456
EC:4 catalyzed processnn[STKE:0456] Enzyme that catalyzes the cleavage of C-C, C-O, C-S, C-N or other bonds by other means than by hydrolysis or oxidation, with two substrates in one reaction direction, and one in the other. In the latter direction, a molecule (of carbon dioxide, water, etc) is eliminated, thus creating a new double bond or a new ring.nn[GO:0016829] Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
GO:0016829
http://purl.org/obo/owl/GO#GO_0016829
STKE:0456
http://purl.org/obo/owl/STKE#STKE_0456
Palmitoylation
event
Reversible reaction that can affect C,K,T or S residues.
MI:0216
http://purl.org/obo/owl/MI#MI_0216
MI:0216
http://purl.org/obo/owl/MI#MI_0216
Farnesylation
event
MI:0206
http://purl.org/obo/owl/MI#MI_0206
Reversible reaction that can affect C residue.
MI:0206
http://purl.org/obo/owl/MI#MI_0206
Geranylgeranylation
event
MI:0209
http://purl.org/obo/owl/MI#MI_0209
Reversible reaction that can affect C residue.
MI:0209
http://purl.org/obo/owl/MI#MI_0209
Isoprenylation
event
Polyisoprenylation
Binding of FasL and Fas in extracellular
event
REACT:1426.2
http://purl.org/obo/owl/REACT#REACT_1426.2
IMR:0010252
http://purl.org/obo/owl/IMR#IMR_0010252
IMR:0000022
http://purl.org/obo/owl/IMR#IMR_0000022
induction of apoptosis by extracellular signals
FASL binds FAS Receptor
Trimerization of Fas in plasma membrane
event
REACT:606.2
http://purl.org/obo/owl/REACT#REACT_606.2
IMR:0010252
http://purl.org/obo/owl/IMR#IMR_0010252
Trimerization of the FASL:FAS receptor complex
Fas trimerization
Binding of Fas and FADD in cytosol
event
IMR:0010252
http://purl.org/obo/owl/IMR#IMR_0010252
FasL:Fas binds FADD
IMR:0100463
http://purl.org/obo/owl/IMR#IMR_0100463
REACT:2191.3
http://purl.org/obo/owl/REACT#REACT_2191.3
Binding of FADD and pro-caspase8/10 in cytosol
event
IMR:0100300
http://purl.org/obo/owl/IMR#IMR_0100300
IMR:0100301
http://purl.org/obo/owl/IMR#IMR_0100301
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-10
DISC complex formation
IMR:0100463
http://purl.org/obo/owl/IMR#IMR_0100463
REACT:1143.2
http://purl.org/obo/owl/REACT#REACT_1143.2
REACT:1543.2
http://purl.org/obo/owl/REACT#REACT_1543.2
Binding of FADD and pro-caspase8 in cytosol
event
IMR:0100300
http://purl.org/obo/owl/IMR#IMR_0100300
DISC complex formation
REACT:1038.2
http://purl.org/obo/owl/REACT#REACT_1038.2
IMR:0100463
http://purl.org/obo/owl/IMR#IMR_0100463
REACT:1543.2
http://purl.org/obo/owl/REACT#REACT_1543.2
Binding of FADD and pro-caspase10 in cytosol
event
IMR:0100301
http://purl.org/obo/owl/IMR#IMR_0100301
DISC complex formation
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-10
IMR:0100463
http://purl.org/obo/owl/IMR#IMR_0100463
REACT:1143.2
http://purl.org/obo/owl/REACT#REACT_1143.2
REACT:1418.2
http://purl.org/obo/owl/REACT#REACT_1418.2
Caspase8/10 activation signaling
event
GO:0006919
http://purl.org/obo/owl/GO#GO_0006919
Homodimerization of Caspase8 in cytosol
event
IMR:0100300
http://purl.org/obo/owl/IMR#IMR_0100300
REACT:1159.2
http://purl.org/obo/owl/REACT#REACT_1159.2
Caspase8 homodimer formation
Formation of Caspase-8 dimer
Hydrolysis of pro-caspase8 in cytosol
event
GO:0006919
http://purl.org/obo/owl/GO#GO_0006919
IMR:0100300
http://purl.org/obo/owl/IMR#IMR_0100300
Cleavage of pro-caspase8
REACT:832.2
http://purl.org/obo/owl/REACT#REACT_832.2
Activation of Pro-Caspase 8
Binding of TNFR1, TRADD, TRAF2 and RIP in cytosol
event
TNF:TNF-R1 binds TRADD, TRAF2 and RIP Complex
REACT:2175.2
http://purl.org/obo/owl/REACT#REACT_2175.2
IMR:0100464
http://purl.org/obo/owl/IMR#IMR_0100464
IMR:0000060
http://purl.org/obo/owl/IMR#IMR_0000060
IMR:0100423
http://purl.org/obo/owl/IMR#IMR_0100423
IMR:0000269
http://purl.org/obo/owl/IMR#IMR_0000269
Dissociation of TRADD:TRAF2:RIP complex and TNF alpha:TNFR1 in cytosol
event
IMR:0100464
http://purl.org/obo/owl/IMR#IMR_0100464
REACT:1856.1
http://purl.org/obo/owl/REACT#REACT_1856.1
IMR:0100423
http://purl.org/obo/owl/IMR#IMR_0100423
IMR:0000269
http://purl.org/obo/owl/IMR#IMR_0000269
IMR:0000060
http://purl.org/obo/owl/IMR#IMR_0000060
IMR:0000025
http://purl.org/obo/owl/IMR#IMR_0000025
TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex
Binding of TRADD and RIP in cytosol
event
IMR:0100464
http://purl.org/obo/owl/IMR#IMR_0100464
IMR:0000269
http://purl.org/obo/owl/IMR#IMR_0000269
Binding of DR4/5 and APO-2L in extracellular
event
IMR:0001201
http://purl.org/obo/owl/IMR#IMR_0001201
IMR:0001200
http://purl.org/obo/owl/IMR#IMR_0001200
IMR:0001202
http://purl.org/obo/owl/IMR#IMR_0001202
REACT:2170.2
http://purl.org/obo/owl/REACT#REACT_2170.2
TRAIL Binds TRAIL-Receptor2
Trimerization of DR4/5 in plasma membrane
event
REACT:1360.2
http://purl.org/obo/owl/REACT#REACT_1360.2
IMR:0001202
http://purl.org/obo/owl/IMR#IMR_0001202
DR4/5 trimerization
IMR:0001201
http://purl.org/obo/owl/IMR#IMR_0001201
Trimerization of TRAIL: TRAIL receptor-2 complex
Binding of DR4/5 and FADD in cytosol
event
IMR:0001202
http://purl.org/obo/owl/IMR#IMR_0001202
REACT:1721.2
http://purl.org/obo/owl/REACT#REACT_1721.2
IMR:0100463
http://purl.org/obo/owl/IMR#IMR_0100463
IMR:0001201
http://purl.org/obo/owl/IMR#IMR_0001201
TRAIL:TRAIL receptor-2 Trimer Binds FADD
Caspase cascade (not through mitochondria)
event
Intrinsic Pathway for Apoptosis
KEGG:hsa04210
http://purl.org/obo/owl/KEGG#KEGG_hsa04210
KEGG:mmu04210
http://purl.org/obo/owl/KEGG#KEGG_mmu04210
KEGG:rno04210
http://purl.org/obo/owl/KEGG#KEGG_rno04210
Caspase cascade (through mitochondria)
event
REACT:964.2
http://purl.org/obo/owl/REACT#REACT_964.2
Intrinsic Pathway for Apoptosis
KEGG:rno04210
http://purl.org/obo/owl/KEGG#KEGG_rno04210
KEGG:mmu04210
http://purl.org/obo/owl/KEGG#KEGG_mmu04210
KEGG:hsa04210
http://purl.org/obo/owl/KEGG#KEGG_hsa04210
Apoptotic factor activation signaling
event
activation of pro-apoptotic gene products
GO:0008633
http://purl.org/obo/owl/GO#GO_0008633
REACT:697.2
http://purl.org/obo/owl/REACT#REACT_697.2
The conversion of proteins that induce or sustain apoptosis to an active form.
GO:0008633
http://purl.org/obo/owl/GO#GO_0008633
BID activation signaling
event
KEGG:rno04210
http://purl.org/obo/owl/KEGG#KEGG_rno04210
KEGG:mmu04210
http://purl.org/obo/owl/KEGG#KEGG_mmu04210
REACT:701.2
http://purl.org/obo/owl/REACT#REACT_701.2
Activation, myristoylation of BID and translocation to mitochondria
GO:0008633
http://purl.org/obo/owl/GO#GO_0008633
KEGG:hsa04210
http://purl.org/obo/owl/KEGG#KEGG_hsa04210
Hydrolysis of Bid by caspase8 in cytosol
event
Caspase-8 activates BID by cleavage
IMR:0100289
http://purl.org/obo/owl/IMR#IMR_0100289
IMR:0100300
http://purl.org/obo/owl/IMR#IMR_0100300
REACT:1320.1
http://purl.org/obo/owl/REACT#REACT_1320.1
GO:0008633
http://purl.org/obo/owl/GO#GO_0008633
Hydrolysis of Bid by granzyme B in cytosol
event
REACT:1610.2
http://purl.org/obo/owl/REACT#REACT_1610.2
Granzyme-B activates BID by cleavage
IMR:0001203
http://purl.org/obo/owl/IMR#IMR_0001203
IMR:0100289
http://purl.org/obo/owl/IMR#IMR_0100289
Myristoylation of Bid by NMT1 in cytosol
event
IMR:0001212
http://purl.org/obo/owl/IMR#IMR_0001212
IMR:0100289
http://purl.org/obo/owl/IMR#IMR_0100289
PubMed:11099414
http://purl.org/obo/owl/PubMed#PubMed_11099414
REACT:1158.1
http://purl.org/obo/owl/REACT#REACT_1158.1
Myristoylation in cytosol
event
Isoprenylation in unidentified cellular location
event
Myristoylation in unidentified cellular location
event
Translocation of Bid from the cytosol to the mitochondria membrane
event
GO:0001844
http://purl.org/obo/owl/GO#GO_0001844
REACT:1370.3
http://purl.org/obo/owl/REACT#REACT_1370.3
IMR:0100289
http://purl.org/obo/owl/IMR#IMR_0100289
Dissociation of Bid and Bcl-2 in mitochondria membrane
event
IMR:0100261
http://purl.org/obo/owl/IMR#IMR_0100261
REACT:1062.2
http://purl.org/obo/owl/REACT#REACT_1062.2
IMR:0100289
http://purl.org/obo/owl/IMR#IMR_0100289
Dissociation in mitochondria membrane
event
NOXA activation signaling
event
Activation of NOXA and translocation to mitochondria
GO:0008633
http://purl.org/obo/owl/GO#GO_0008633
REACT:1194.2
http://purl.org/obo/owl/REACT#REACT_1194.2
Transcription of NOXA by p53 in nucleus
event
Transactivation of NOXA by p53
REACT:2201.3
http://purl.org/obo/owl/REACT#REACT_2201.3
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
IMR:0001210
http://purl.org/obo/owl/IMR#IMR_0001210
Transcription of NOXA by E2F-1 in nucleus
event
IMR:0001210
http://purl.org/obo/owl/IMR#IMR_0001210
Transactivation of NOXA by E2F1
IMR:0000839
http://purl.org/obo/owl/IMR#IMR_0000839
REACT:1872.3
http://purl.org/obo/owl/REACT#REACT_1872.3
Translocation of NOXA from the cytosol to the mitochondria membrane
event
IMR:0001210
http://purl.org/obo/owl/IMR#IMR_0001210
GO:0001844
http://purl.org/obo/owl/GO#GO_0001844
REACT:1585.3
http://purl.org/obo/owl/REACT#REACT_1585.3
PUMA activation signaling
event
GO:0008633
http://purl.org/obo/owl/GO#GO_0008633
REACT:121.2
http://purl.org/obo/owl/REACT#REACT_121.2
Activation of NOXA and translocation to mitochondria
Transcription of PUMA by E2F-1 in nucleus
event
REACT:284.3
http://purl.org/obo/owl/REACT#REACT_284.3
IMR:0001211
http://purl.org/obo/owl/IMR#IMR_0001211
Transactivation of PUMA by E2F1
IMR:0000839
http://purl.org/obo/owl/IMR#IMR_0000839
Transcription of PUMA by p53 in nucleus
event
REACT:1555.3
http://purl.org/obo/owl/REACT#REACT_1555.3
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
IMR:0001211
http://purl.org/obo/owl/IMR#IMR_0001211
Transactivation of PUMA by p53
Translocation of PUMA from cytosol to the mitochondria membrane
event
REACT:104.3
http://purl.org/obo/owl/REACT#REACT_104.3
IMR:0001211
http://purl.org/obo/owl/IMR#IMR_0001211
GO:0001844
http://purl.org/obo/owl/GO#GO_0001844
Translocation of PUMA protein to mitochondria
Bim activation signaling
event
Activation of BIM and translocation to mitochondria
REACT:1650.2
http://purl.org/obo/owl/REACT#REACT_1650.2
GO:0008633
http://purl.org/obo/owl/GO#GO_0008633
Phosphorylation of DLC1 by MAPK8 in cytosol
event
REACT:1888.3
http://purl.org/obo/owl/REACT#REACT_1888.3
IMR:0001213
http://purl.org/obo/owl/IMR#IMR_0001213
IMR:0000683
http://purl.org/obo/owl/IMR#IMR_0000683
Dissociation of Bim and dynein:myosin V in cytosol
event
IMR:0000191
http://purl.org/obo/owl/IMR#IMR_0000191
IMR:0100291
http://purl.org/obo/owl/IMR#IMR_0100291
IMR:0000200
http://purl.org/obo/owl/IMR#IMR_0000200
PubMed:10198631
http://purl.org/obo/owl/PubMed#PubMed_10198631
Translocation of Bim from the cytosol to the mitochondria membrane
event
IMR:0100291
http://purl.org/obo/owl/IMR#IMR_0100291
GO:0001844
http://purl.org/obo/owl/GO#GO_0001844
REACT:750.3
http://purl.org/obo/owl/REACT#REACT_750.3
Translocation of BIM to mitochondria
Bmf activation signaling
event
Activation of BMF and translocation to mitochondria
GO:0008633
http://purl.org/obo/owl/GO#GO_0008633
REACT:2100.2
http://purl.org/obo/owl/REACT#REACT_2100.2
Phosphorylation of DLC2 by MAPK8 in cytosol
event
IMR:0000683
http://purl.org/obo/owl/IMR#IMR_0000683
REACT:1981.3
http://purl.org/obo/owl/REACT#REACT_1981.3
IMR:0001209
http://purl.org/obo/owl/IMR#IMR_0001209
Dissociation of Bmf and dynein:myosin V in cytosol
event
IMR:0000200
http://purl.org/obo/owl/IMR#IMR_0000200
IMR:0001208
http://purl.org/obo/owl/IMR#IMR_0001208
IMR:0000191
http://purl.org/obo/owl/IMR#IMR_0000191
Translocation of Bmf from the cytosol to the mitochondria membrane
event
REACT:600.3
http://purl.org/obo/owl/REACT#REACT_600.3
Translocation of BMF to mitochondria
IMR:0001208
http://purl.org/obo/owl/IMR#IMR_0001208
GO:0001844
http://purl.org/obo/owl/GO#GO_0001844
Inactivation in mitochondria membrane
event
Inactivation of Bcl-2 by Bad in mitochondria membrane
event
REACT:330.1
http://purl.org/obo/owl/REACT#REACT_330.1
IMR:0100288
http://purl.org/obo/owl/IMR#IMR_0100288
IMR:0100261
http://purl.org/obo/owl/IMR#IMR_0100261
Inactivation of Bcl-xL by Bad in mitochondria membrane
event
IMR:0100288
http://purl.org/obo/owl/IMR#IMR_0100288
IMR:0100293
http://purl.org/obo/owl/IMR#IMR_0100293
REACT:21278.1
http://purl.org/obo/owl/REACT#REACT_21278.1
Inactivation of Bid by Bcl-2 in mitochondria membrane
event
KEGG:mmu04210
http://purl.org/obo/owl/KEGG#KEGG_mmu04210
KEGG:rno04210
http://purl.org/obo/owl/KEGG#KEGG_rno04210
IMR:0100289
http://purl.org/obo/owl/IMR#IMR_0100289
KEGG:hsa04210
http://purl.org/obo/owl/KEGG#KEGG_hsa04210
REACT:784.2
http://purl.org/obo/owl/REACT#REACT_784.2
IMR:0100261
http://purl.org/obo/owl/IMR#IMR_0100261
Inactivation of Bcl-2 by Bim in mitochondria membrane
event
IMR:0100261
http://purl.org/obo/owl/IMR#IMR_0100261
IMR:0100291
http://purl.org/obo/owl/IMR#IMR_0100291
REACT:330.1
http://purl.org/obo/owl/REACT#REACT_330.1
Inactivation of Bcl-xL by Bid in mitochondria membrane
event
REACT:21278.1
http://purl.org/obo/owl/REACT#REACT_21278.1
IMR:0100289
http://purl.org/obo/owl/IMR#IMR_0100289
IMR:0100293
http://purl.org/obo/owl/IMR#IMR_0100293
Inactivation of Bcl-xL by Bim in mitochondria membrane
event
IMR:0100293
http://purl.org/obo/owl/IMR#IMR_0100293
IMR:0100291
http://purl.org/obo/owl/IMR#IMR_0100291
REACT:21278.1
http://purl.org/obo/owl/REACT#REACT_21278.1
Inactivation of Bcl-2 by NOXA in mitochondria membrane
event
IMR:0100261
http://purl.org/obo/owl/IMR#IMR_0100261
REACT:330.1
http://purl.org/obo/owl/REACT#REACT_330.1
IMR:0001210
http://purl.org/obo/owl/IMR#IMR_0001210
Inactivation of Bcl-2 by PUMA in mitochondria membrane
event
IMR:0100261
http://purl.org/obo/owl/IMR#IMR_0100261
REACT:330.1
http://purl.org/obo/owl/REACT#REACT_330.1
IMR:0001211
http://purl.org/obo/owl/IMR#IMR_0001211
Inactivation of Bcl-xL by PUMA in mitochondria membrane
event
REACT:21278.1
http://purl.org/obo/owl/REACT#REACT_21278.1
IMR:0100293
http://purl.org/obo/owl/IMR#IMR_0100293
IMR:0001211
http://purl.org/obo/owl/IMR#IMR_0001211
Inactivation of Bcl-2 family by pro-apoptotic factor in mitochondria membrane
event
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
IMR:0100706
http://purl.org/obo/owl/IMR#IMR_0100706
REACT:21278.1
http://purl.org/obo/owl/REACT#REACT_21278.1
REACT:330.1
http://purl.org/obo/owl/REACT#REACT_330.1
Activation of Bax by Bid in cytosol
event
REACT:1506.2
http://purl.org/obo/owl/REACT#REACT_1506.2
tBID activates BAX protein
PubMed:10950869
http://purl.org/obo/owl/PubMed#PubMed_10950869
IMR:0100289
http://purl.org/obo/owl/IMR#IMR_0100289
IMR:0000453
http://purl.org/obo/owl/IMR#IMR_0000453
GO:0008633
http://purl.org/obo/owl/GO#GO_0008633
Activation in mitochondria membrane
event
Bak activation signaling
event
REACT:707.3
http://purl.org/obo/owl/REACT#REACT_707.3
GO:0008633
http://purl.org/obo/owl/GO#GO_0008633
Activation and oligomerization of BAK protein
Activation of Bak by Bid in mitochondria membrane
event
tBID activates BAK protein
GO:0008633
http://purl.org/obo/owl/GO#GO_0008633
IMR:0000452
http://purl.org/obo/owl/IMR#IMR_0000452
IMR:0100289
http://purl.org/obo/owl/IMR#IMR_0100289
REACT:1424.3
http://purl.org/obo/owl/REACT#REACT_1424.3
Oligomerization of Bak
event
REACT:507.2
http://purl.org/obo/owl/REACT#REACT_507.2
Oligomerization of BAK at the mitochondrial membrane
IMR:0000452
http://purl.org/obo/owl/IMR#IMR_0000452
Permeabilization of mitochondria
event
Permeabilization of mitochondria and Translocation of cytochrome c/SMAC from mitochondria to cytosol
event
IMR:0001206
http://purl.org/obo/owl/IMR#IMR_0001206
Release of apoptotic factors from the mitochondria
IMR:0001207
http://purl.org/obo/owl/IMR#IMR_0001207
REACT:1322.1
http://purl.org/obo/owl/REACT#REACT_1322.1
Translocation from mitochondria to cytosol
event
Permeabilization of mitochondria and Translocation of SMAC from mitochondria to cytosol
event
Release of SMAC from mitochondria
IMR:0001207
http://purl.org/obo/owl/IMR#IMR_0001207
REACT:1101.3
http://purl.org/obo/owl/REACT#REACT_1101.3
Cytochrome c mediated signaling
event
Cytochrome c-mediated apoptotic response
Effector caspase3 / 7 activation signaling (through Cyt c)
Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis, mediated by cytochrome c.
GO:0008635
http://purl.org/obo/owl/GO#GO_0008635
KEGG:rno04210
http://purl.org/obo/owl/KEGG#KEGG_rno04210
REACT:831.1
http://purl.org/obo/owl/REACT#REACT_831.1
KEGG:mmu04210
http://purl.org/obo/owl/KEGG#KEGG_mmu04210
KEGG:hsa04210
http://purl.org/obo/owl/KEGG#KEGG_hsa04210
GO:0008635
http://purl.org/obo/owl/GO#GO_0008635
SMAC mediated signaling
event
REACT:666.1
http://purl.org/obo/owl/REACT#REACT_666.1
SMAC-mediated apoptotic response
Apoptosome formation in cytosol
event
Formation of apoptosome
REACT:89.2
http://purl.org/obo/owl/REACT#REACT_89.2
Binding of Cyt c:Apaf1 and procaspase9 in cytosol
event
REACT:39.3
http://purl.org/obo/owl/REACT#REACT_39.3
IMR:0001204
http://purl.org/obo/owl/IMR#IMR_0001204
IMR:0001206
http://purl.org/obo/owl/IMR#IMR_0001206
Cytochrome C:Apaf-1 binds Procaspase-9
IMR:0100299
http://purl.org/obo/owl/IMR#IMR_0100299
Hydrolysis of Procaspase9 to Caspase9 in cytosol
event
IMR:0100299
http://purl.org/obo/owl/IMR#IMR_0100299
REACT:2116.3
http://purl.org/obo/owl/REACT#REACT_2116.3
Cleavage of Procaspase-9 to Caspase-9
Hydrolysis of Caspase3/6/7 by Caspase9 in cytosol
event
IMR:0100296
http://purl.org/obo/owl/IMR#IMR_0100296
Activation of caspases through apoptosome-mediated cleavage
IMR:0100297
http://purl.org/obo/owl/IMR#IMR_0100297
REACT:607.3
http://purl.org/obo/owl/REACT#REACT_607.3
IMR:0100299
http://purl.org/obo/owl/IMR#IMR_0100299
IMR:0100298
http://purl.org/obo/owl/IMR#IMR_0100298
Hydrolysis of Procaspase7 to Caspase7 by Caspase9 in cytosol
event
IMR:0100299
http://purl.org/obo/owl/IMR#IMR_0100299
IMR:0100298
http://purl.org/obo/owl/IMR#IMR_0100298
Cleavage of Procaspase-7 by the apoptosome
REACT:2165.3
http://purl.org/obo/owl/REACT#REACT_2165.3
Hydrolysis of Procaspase3 to Caspase3 by Caspase9 in cytosol
event
IMR:0100299
http://purl.org/obo/owl/IMR#IMR_0100299
REACT:1460.5
http://purl.org/obo/owl/REACT#REACT_1460.5
Cleavage of Procaspase-3 by the apoptosome
IMR:0100296
http://purl.org/obo/owl/IMR#IMR_0100296
Binding of SMAC and IAP in cytosol
event
IMR:0000454
http://purl.org/obo/owl/IMR#IMR_0000454
REACT:2190.2
http://purl.org/obo/owl/REACT#REACT_2190.2
IMR:0001207
http://purl.org/obo/owl/IMR#IMR_0001207
SMAC binds to IAPs
Dissociation of Caspase3 and SMAC:XIAP in cytosol
event
IMR:0001207
http://purl.org/obo/owl/IMR#IMR_0001207
IMR:0100296
http://purl.org/obo/owl/IMR#IMR_0100296
IMR:0100331
http://purl.org/obo/owl/IMR#IMR_0100331
REACT:1300.3
http://purl.org/obo/owl/REACT#REACT_1300.3
SMAC binds XIAP:Caspase-3
Dissociation of Caspase and SMAC:IAP in cytosol
event
IMR:0001207
http://purl.org/obo/owl/IMR#IMR_0001207
IMR:0000305
http://purl.org/obo/owl/IMR#IMR_0000305
IMR:0000454
http://purl.org/obo/owl/IMR#IMR_0000454
SMAC-mediated dissociation of IAP:caspase complexes
REACT:1767.2
http://purl.org/obo/owl/REACT#REACT_1767.2
Binding of SMAC and XIAP:Caspase3 in cytosol
event
SMAC binds XIAP:Caspase-3
REACT:1090.2
http://purl.org/obo/owl/REACT#REACT_1090.2
IMR:0100331
http://purl.org/obo/owl/IMR#IMR_0100331
IMR:0001207
http://purl.org/obo/owl/IMR#IMR_0001207
IMR:0100296
http://purl.org/obo/owl/IMR#IMR_0100296
Binding of SMAC and XIAP:Caspase7 in cytosol
event
SMAC binds XIAP:Caspase-7
REACT:2091.2
http://purl.org/obo/owl/REACT#REACT_2091.2
IMR:0100331
http://purl.org/obo/owl/IMR#IMR_0100331
IMR:0100298
http://purl.org/obo/owl/IMR#IMR_0100298
IMR:0001207
http://purl.org/obo/owl/IMR#IMR_0001207
Binding of SMAC and XIAP:Caspase9 in cytosol
event
REACT:1312.2
http://purl.org/obo/owl/REACT#REACT_1312.2
IMR:0100331
http://purl.org/obo/owl/IMR#IMR_0100331
IMR:0100299
http://purl.org/obo/owl/IMR#IMR_0100299
SMAC binds XIAP:Caspase-9
IMR:0001207
http://purl.org/obo/owl/IMR#IMR_0001207
Dissociation of Caspase7 and SMAC:XIAP in cytosol
event
Dissociation of Caspase-7 from SMAC:XIAP:Caspase-7
IMR:0100331
http://purl.org/obo/owl/IMR#IMR_0100331
REACT:2102.3
http://purl.org/obo/owl/REACT#REACT_2102.3
IMR:0100298
http://purl.org/obo/owl/IMR#IMR_0100298
IMR:0001207
http://purl.org/obo/owl/IMR#IMR_0001207
Dissociation of Caspase9 and SMAC:XIAP in cytosol
event
IMR:0001207
http://purl.org/obo/owl/IMR#IMR_0001207
IMR:0100331
http://purl.org/obo/owl/IMR#IMR_0100331
IMR:0100299
http://purl.org/obo/owl/IMR#IMR_0100299
Dissociation of Caspase-9 from SMAC:XIAP:Caspase-9
REACT:1035.3
http://purl.org/obo/owl/REACT#REACT_1035.3
Caspase9 activation signaling
event
GO:0006919
http://purl.org/obo/owl/GO#GO_0006919
Caspase10 activation signaling
event
GO:0008633
http://purl.org/obo/owl/GO#GO_0008633
GO:0006919
http://purl.org/obo/owl/GO#GO_0006919
Homodimerization of Caspase9 in cytosol
event
IMR:0100299
http://purl.org/obo/owl/IMR#IMR_0100299
Caspase9 homodimer formation
Caspase3/6/7 activation signaling (through mitochondria)
event
GO:0006919
http://purl.org/obo/owl/GO#GO_0006919
Activation of Effector Caspases
Caspase3/6/7 homodimer formation in cytosol
event
IMR:0100296
http://purl.org/obo/owl/IMR#IMR_0100296
IMR:0100298
http://purl.org/obo/owl/IMR#IMR_0100298
IMR:0100297
http://purl.org/obo/owl/IMR#IMR_0100297
Caspase8 activation signaling
event
GO:0006919
http://purl.org/obo/owl/GO#GO_0006919
GO:0008633
http://purl.org/obo/owl/GO#GO_0008633
REACT:1503.2
http://purl.org/obo/owl/REACT#REACT_1503.2
Activation of Pro-Caspase 8
Hydrolysis of pro-caspase10 in cytosol
event
Activation of Pro-Caspase10
GO:0006919
http://purl.org/obo/owl/GO#GO_0006919
Cleavage of pro-caspase10
IMR:0100301
http://purl.org/obo/owl/IMR#IMR_0100301
Homodimerization of Caspase10 in cytosol
event
Caspase10 homodimer formation
IMR:0100301
http://purl.org/obo/owl/IMR#IMR_0100301
Formation of Caspase10 dimer
AIF mediated signaling
event
KEGG:mmu04210
http://purl.org/obo/owl/KEGG#KEGG_mmu04210
KEGG:rno04210
http://purl.org/obo/owl/KEGG#KEGG_rno04210
KEGG:hsa04210
http://purl.org/obo/owl/KEGG#KEGG_hsa04210
Nuclear import of AIF
event
UniProt:O95831
http://purl.org/obo/owl/UniProt#UniProt_O95831
Caspase3/6/7 activation signaling (not through mitochondria)
event
GO:0006919
http://purl.org/obo/owl/GO#GO_0006919
Activation of Effector Caspases
Hydrolysis of Procaspase3/6/7 by caspase8/10 in cytosol
event
IMR:0100300
http://purl.org/obo/owl/IMR#IMR_0100300
IMR:0100301
http://purl.org/obo/owl/IMR#IMR_0100301
IMR:0100298
http://purl.org/obo/owl/IMR#IMR_0100298
IMR:0100297
http://purl.org/obo/owl/IMR#IMR_0100297
IMR:0100296
http://purl.org/obo/owl/IMR#IMR_0100296
Hydrolysis of ICAD by Caspase3/7 in cytosol
event
UniProt:O00273
http://purl.org/obo/owl/UniProt#UniProt_O00273
IMR:0100298
http://purl.org/obo/owl/IMR#IMR_0100298
IMR:0100296
http://purl.org/obo/owl/IMR#IMR_0100296
Nuclear import of CAD
event
UniProt:O76075
http://purl.org/obo/owl/UniProt#UniProt_O76075
DNA fragmentation during apoptosis
event
The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
GO:0006309
http://purl.org/obo/owl/GO#GO_0006309
Apoptosis induced DNA fragmentation
GO:0006309
http://purl.org/obo/owl/GO#GO_0006309
REACT:1213.3
http://purl.org/obo/owl/REACT#REACT_1213.3
Regulation of Caspase cascade (through mitochondria)
event
Negative regulation of Caspase cascade
event
Positive regulation of Caspase cascade
event
Regulation of Caspase cascade (not through mitochondria)
event
Negative regulation of Caspase cascade (not through mitochondria)
event
Positive regulation of Caspase cascade (not through mitochondria)
event
Binding of CAD and ICAD in cytosol
event
UniProt:O00273
http://purl.org/obo/owl/UniProt#UniProt_O00273
UniProt:O76075
http://purl.org/obo/owl/UniProt#UniProt_O76075
REACT:14379.1
http://purl.org/obo/owl/REACT#REACT_14379.1
Binding of Caspase3/7/9 and IAP in cytosol
event
IMR:0100296
http://purl.org/obo/owl/IMR#IMR_0100296
IMR:0100298
http://purl.org/obo/owl/IMR#IMR_0100298
IMR:0000454
http://purl.org/obo/owl/IMR#IMR_0000454
IMR:0100299
http://purl.org/obo/owl/IMR#IMR_0100299
Hydrolysis in nucleus
event
DNA fragmentation by AIF in inner space of nucleus
event
UniProt:O95831
http://purl.org/obo/owl/UniProt#UniProt_O95831
DNA fragmentation by CAD in inner space of nucleus
event
UniProt:O76075
http://purl.org/obo/owl/UniProt#UniProt_O76075
Hydrolysis of cytosolic protein by caspase3/6/7 in cytosol
event
REACT:13541.1
http://purl.org/obo/owl/REACT#REACT_13541.1
IMR:0100296
http://purl.org/obo/owl/IMR#IMR_0100296
cleavage of cytosolic proteins during apoptosis
GO:0030972
http://purl.org/obo/owl/GO#GO_0030972
IMR:0100298
http://purl.org/obo/owl/IMR#IMR_0100298
IMR:0100297
http://purl.org/obo/owl/IMR#IMR_0100297
Apoptotic factor inactivation signaling
event
Cytosolic cation ion concentration decline
event
Dissociation outside the ER membrane
event
Dissociation in mitochondria
event
Dissociation in ER
event
Binding in ER
event
Binding in mitochondria
event
Binding outside the ER membrane
event
Dissociation outside the mitochondria membrane
event
Binding in inner space of mitochondria
event
Binding in inner space of ER
event
Binding in inner space of nucleus
event
Dissociation in nucleus
event
Dissociation in ER membrane
event
Dissociation in inner space of ER
event
Dissociation in inner space of mitochondria
event
Dissociation in inner space of nucleus
event
Dissociation in nuclear membrane
event
Dissociation outside the nuclear membrane
event
Dephosphorylation in nucleus
event
Dephosphorylation in inner space of nucleus
event
Hydrolysis in inner space of nucleus
event
Isomerization in cytosol
event
Isomerization in unidentified cellular location
event
SUMOylation in unidentified cellular location
event
SUMOylation in cytosol
event
Proteasome degradation of cyclin D in cytosol
event
IMR:0100614
http://purl.org/obo/owl/IMR#IMR_0100614
REACT:2142.4
http://purl.org/obo/owl/REACT#REACT_2142.4
Lyase process in unidentified cellular location
event
Oxidation/Reduction in unidentified cellular location
event
Oxidation/Reduction in cytosol
event
Farnesylation in unidentified cellular location
event
Geranylgeranylation in unidentified cellular location
event
Geranylgeranylation in cytosol
event
Palmitoylation in cytosol
event
Palmitoylation in unidentified cellular location
event
Interaction in cytosol
event
OBSOLETE: remap to 'Unknown interaction' IEV:0000922.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Interaction in unidentified cellular location
event
OBSOLETE: remap to 'Unknown interaction' IEV:0000922.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Decarboxylation
event
EC:4.1.1
http://purl.org/obo/owl/EC#EC_4.1.1
Decarboxylation in the cytosol
event
Decarboxylation in the unidentified cellular location
event
G1-S-phase transition
event
IEV:0000367
G1-S-phase transition process [Plant]
GO:0000082
http://purl.org/obo/owl/GO#GO_0000082
KEGG:hsa04110
http://purl.org/obo/owl/KEGG#KEGG_hsa04110
Progression from G1 phase to S phase of the mitotic cell cycle.
GO:0000082
http://purl.org/obo/owl/GO#GO_0000082
Binding of Cdk4/6 and cyclin D in cytosol
event
IMR:0100600
http://purl.org/obo/owl/IMR#IMR_0100600
IMR:0100602
http://purl.org/obo/owl/IMR#IMR_0100602
IMR:0100614
http://purl.org/obo/owl/IMR#IMR_0100614
REACT:2081.2
http://purl.org/obo/owl/REACT#REACT_2081.2
Nuclear import of Cdk4/6_p:cyclin D
event
IMR:0100600
http://purl.org/obo/owl/IMR#IMR_0100600
IMR:0100614
http://purl.org/obo/owl/IMR#IMR_0100614
IMR:0100602
http://purl.org/obo/owl/IMR#IMR_0100602
REACT:713.3
http://purl.org/obo/owl/REACT#REACT_713.3
Phosphorylation of RB by Cdk4/6 in inner space of nucleus
event
IMR:0100602
http://purl.org/obo/owl/IMR#IMR_0100602
IMR:0000461
http://purl.org/obo/owl/IMR#IMR_0000461
IMR:0100600
http://purl.org/obo/owl/IMR#IMR_0100600
REACT:1882.4
http://purl.org/obo/owl/REACT#REACT_1882.4
Binding of E2F and DP-1 in inner space of nucleus
event
IMR:0000845
http://purl.org/obo/owl/IMR#IMR_0000845
IMR:0000848
http://purl.org/obo/owl/IMR#IMR_0000848
Transcription by E2F in nucleus
event
IMR:0000848
http://purl.org/obo/owl/IMR#IMR_0000848
Dissociation of E2F-1 and RB_p in inner space of nucleus
event
IMR:0000839
http://purl.org/obo/owl/IMR#IMR_0000839
IMR:0000461
http://purl.org/obo/owl/IMR#IMR_0000461
Binding of Cdk2 and cyclin E in cytosol
event
REACT:1683.3
http://purl.org/obo/owl/REACT#REACT_1683.3
IMR:0100618
http://purl.org/obo/owl/IMR#IMR_0100618
IMR:0100598
http://purl.org/obo/owl/IMR#IMR_0100598
Nuclear import of Cdk2_p:cyclin E
event
IMR:0100598
http://purl.org/obo/owl/IMR#IMR_0100598
IMR:0100618
http://purl.org/obo/owl/IMR#IMR_0100618
REACT:425.2
http://purl.org/obo/owl/REACT#REACT_425.2
Gene expression of p21 by p53
event
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
IMR:0100383
http://purl.org/obo/owl/IMR#IMR_0100383
Transactivation of p21 by p53
Phosphorylation of RB by Cdk2 in inner space of nucleus
event
IMR:0000461
http://purl.org/obo/owl/IMR#IMR_0000461
REACT:8993.1
http://purl.org/obo/owl/REACT#REACT_8993.1
IMR:0100598
http://purl.org/obo/owl/IMR#IMR_0100598
Phosphorylation in inner space of nucleus
event
Regulation of S phase
event
A cell cycle process that modulates the rate or extent of the progression through the S phase of the cell cycle.
GO:0033261
http://purl.org/obo/owl/GO#GO_0033261
GO:0033261
http://purl.org/obo/owl/GO#GO_0033261
regulation of progression through S phase
Cyclin D degradation signaling
event
The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions.
GO:0008054
http://purl.org/obo/owl/GO#GO_0008054
GO:0008054
http://purl.org/obo/owl/GO#GO_0008054
Proteasome degradation of cyclin E in cytosol
event
IMR:0100618
http://purl.org/obo/owl/IMR#IMR_0100618
REACT:926.3
http://purl.org/obo/owl/REACT#REACT_926.3
Ubiquitination of Cyclin E in cytosol
event
IMR:0100618
http://purl.org/obo/owl/IMR#IMR_0100618
REACT:926.3
http://purl.org/obo/owl/REACT#REACT_926.3
Binding of INK4 family and Cdk4/6 in cytosol
event
REACT:7947.1
http://purl.org/obo/owl/REACT#REACT_7947.1
IMR:0000447
http://purl.org/obo/owl/IMR#IMR_0000447
IMR:0100602
http://purl.org/obo/owl/IMR#IMR_0100602
IMR:0100600
http://purl.org/obo/owl/IMR#IMR_0100600
Binding of p16 and Cdk4/6 in cytosol
event
IMR:0100600
http://purl.org/obo/owl/IMR#IMR_0100600
IMR:0701007
http://purl.org/obo/owl/IMR#IMR_0701007
IMR:0100602
http://purl.org/obo/owl/IMR#IMR_0100602
Interacts strongly with CDK4 and CDK6. Inhibits their ability to interact with cyclins D. Could act as a negative regulator of the proliferation of normal cells.
UniProt:P42771
http://purl.org/obo/owl/UniProt#UniProt_P42771
Binding of p15 and Cdk4/6 in cytosol
event
IMR:0100602
http://purl.org/obo/owl/IMR#IMR_0100602
IMR:0701008
http://purl.org/obo/owl/IMR#IMR_0701008
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
UniProt:P42772
http://purl.org/obo/owl/UniProt#UniProt_P42772
IMR:0100600
http://purl.org/obo/owl/IMR#IMR_0100600
Binding of p27 and Cdk2 in inner space of nucleus
event
Involved in G1 arrest. May mediate TGF beta-induced G1 arrest. Binds to and inhibits complexes formed by cyclin E-CDK2, cyclin A-CDK2, and cyclin D1-CDK4. Interaction with nucleoporin NUP50 is required for nuclear import and for degradation of phosphorylated p27Kip1 after nuclear import.
UniProt:P46527
http://purl.org/obo/owl/UniProt#UniProt_P46527
REACT:334.3
http://purl.org/obo/owl/REACT#REACT_334.3
IMR:0100598
http://purl.org/obo/owl/IMR#IMR_0100598
IMR:0100384
http://purl.org/obo/owl/IMR#IMR_0100384
Binding of p21 and Cdk2 in inner space of nucleus
event
May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. May bind to and inhibit cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.
UniProt:P38936
http://purl.org/obo/owl/UniProt#UniProt_P38936
IMR:0100383
http://purl.org/obo/owl/IMR#IMR_0100383
IMR:0100598
http://purl.org/obo/owl/IMR#IMR_0100598
REACT:334.3
http://purl.org/obo/owl/REACT#REACT_334.3
Binding of GADD45 and PCNA in cytosol
event
Binds to proliferating cell nuclear antigen. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.
UniProt:P24522
http://purl.org/obo/owl/UniProt#UniProt_P24522
IMR:0000559
http://purl.org/obo/owl/IMR#IMR_0000559
UniProt:P12004
http://purl.org/obo/owl/UniProt#UniProt_P12004
Binding of p18 and Cdk4/6 in cytosol
event
Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
UniProt:P42773
http://purl.org/obo/owl/UniProt#UniProt_P42773
IMR:0701009
http://purl.org/obo/owl/IMR#IMR_0701009
IMR:0100602
http://purl.org/obo/owl/IMR#IMR_0100602
IMR:0100600
http://purl.org/obo/owl/IMR#IMR_0100600
Binding of p19 and Cdk4/6 in cytosol
event
Interacts strongly with CDK4 and CDK6.
UniProt:P55273
http://purl.org/obo/owl/UniProt#UniProt_P55273
IMR:0100602
http://purl.org/obo/owl/IMR#IMR_0100602
IMR:0701013
http://purl.org/obo/owl/IMR#IMR_0701013
IMR:0100600
http://purl.org/obo/owl/IMR#IMR_0100600
S phase
event
KEGG:hsa04110
http://purl.org/obo/owl/KEGG#KEGG_hsa04110
GO:0051320
http://purl.org/obo/owl/GO#GO_0051320
MeSH:D016196
http://purl.org/obo/owl/MeSH#MeSH_D016196
Progression through S phase, the part of the cell cycle during which DNA synthesis takes place.
GO:0051320
http://purl.org/obo/owl/GO#GO_0051320
Negative regulation of S phase
event
Positive regulation of S phase
event
Dephosphorylation Cdk2 by Cdc25A in cytosol
event
Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity. It also dephosphorylates CDK2 in complex with cyclin E, in vitro.
UniProt:P30304
http://purl.org/obo/owl/UniProt#UniProt_P30304
IMR:0100632
http://purl.org/obo/owl/IMR#IMR_0100632
IMR:0100598
http://purl.org/obo/owl/IMR#IMR_0100598
REACT:592.4
http://purl.org/obo/owl/REACT#REACT_592.4
Binding of Cdk7 and Cyclin H in cytosol
event
IMR:0100625
http://purl.org/obo/owl/IMR#IMR_0100625
IMR:0100603
http://purl.org/obo/owl/IMR#IMR_0100603
Phosphorylation of Cdk2 by Cdk7 in cytosol
Thr160
event
IMR:0100603
http://purl.org/obo/owl/IMR#IMR_0100603
IMR:0100598
http://purl.org/obo/owl/IMR#IMR_0100598
Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive carboxyl-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
UniProt:P50613
http://purl.org/obo/owl/UniProt#UniProt_P50613
Binding of Cdk2 and Cyclin A in cytosol
event
IMR:0100607
http://purl.org/obo/owl/IMR#IMR_0100607
REACT:8996.1
http://purl.org/obo/owl/REACT#REACT_8996.1
IMR:0100598
http://purl.org/obo/owl/IMR#IMR_0100598
Transcription by E2F-1 in nucleus
event
IMR:0000839
http://purl.org/obo/owl/IMR#IMR_0000839
REACT:22145.1
http://purl.org/obo/owl/REACT#REACT_22145.1
p53 signaling pathway
event
DNA damage
event
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand ( PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired ( DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
MeSH:D004249
http://purl.org/obo/owl/MeSH#MeSH_D004249
MeSH:D004249
http://purl.org/obo/owl/MeSH#MeSH_D004249
Activation of ATM by damaged DNA in cytosol
event
UniProt:Q13315
http://purl.org/obo/owl/UniProt#UniProt_Q13315
G1 phase
event
Progression through G1 phase, one of two 'gap' phases in the cell cycle; G1 is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis.
GO:0051318
http://purl.org/obo/owl/GO#GO_0051318
GO:0051318
http://purl.org/obo/owl/GO#GO_0051318
MeSH:D016193
http://purl.org/obo/owl/MeSH#MeSH_D016193
p53 signaling pathway (through GADD45)
event
Negative feedback regulation of p53 signaling pathway by Mdm2
event
IMR:0100660
http://purl.org/obo/owl/IMR#IMR_0100660
Proteasome degradation of p53 in cytosol
event
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
PubMed:10721693
http://purl.org/obo/owl/PubMed#PubMed_10721693
PubMed:15021897
http://purl.org/obo/owl/PubMed#PubMed_15021897
Gene expression by p53
event
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
Gene expression of GADD45 by p53
event
IMR:0000559
http://purl.org/obo/owl/IMR#IMR_0000559
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
Gene expression of 14-3-3 by p53
event
IMR:0000456
http://purl.org/obo/owl/IMR#IMR_0000456
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
Gene expression of Mdm2 by p53
event
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
PubMed:12860999
http://purl.org/obo/owl/PubMed#PubMed_12860999
IMR:0100660
http://purl.org/obo/owl/IMR#IMR_0100660
p53 signaling pathway (through apoptotic factor)
event
Gene expression of BAX by p53
event
IMR:0000453
http://purl.org/obo/owl/IMR#IMR_0000453
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
Nuclear export of mRNA (GADD45)
event
IMR:0000559
http://purl.org/obo/owl/IMR#IMR_0000559
Transcription of GADD45 by p53 in nucleus
event
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
IMR:0000559
http://purl.org/obo/owl/IMR#IMR_0000559
Translation of GADD45 in cytosol
event
IMR:0000559
http://purl.org/obo/owl/IMR#IMR_0000559
Nuclear export of mRNA (Mdm2)
event
PubMed:12860999
http://purl.org/obo/owl/PubMed#PubMed_12860999
IMR:0100660
http://purl.org/obo/owl/IMR#IMR_0100660
Transcription of Mdm2 by p53 in nucleus
event
IMR:0100660
http://purl.org/obo/owl/IMR#IMR_0100660
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
PubMed:12860999
http://purl.org/obo/owl/PubMed#PubMed_12860999
Translation of Mdm2 in cytosol
event
PubMed:12860999
http://purl.org/obo/owl/PubMed#PubMed_12860999
IMR:0100660
http://purl.org/obo/owl/IMR#IMR_0100660
Regulation of p53 degradation signaling
event
Negative regulation of p53 degradation signaling
event
Positive regulation of p53 degradation signaling
event
Nuclear export of mRNA (p21)
event
IMR:0100383
http://purl.org/obo/owl/IMR#IMR_0100383
Transcription of p21 by p53 in nucleus
event
IMR:0100383
http://purl.org/obo/owl/IMR#IMR_0100383
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
Translation of p21 in cytosol
event
IMR:0100383
http://purl.org/obo/owl/IMR#IMR_0100383
Nuclear export of mRNA (BAX)
event
IMR:0000453
http://purl.org/obo/owl/IMR#IMR_0000453
Transcription of BAX by p53 in nucleus
event
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
IMR:0000453
http://purl.org/obo/owl/IMR#IMR_0000453
Translation of BAX in cytosol
event
IMR:0000453
http://purl.org/obo/owl/IMR#IMR_0000453
Binding of Cdc2 and CyclinB in cytosol
event
Binding of Cdk1 and CyclinB in cytosol
REACT:6216.2
http://purl.org/obo/owl/REACT#REACT_6216.2
IMR:0100610
http://purl.org/obo/owl/IMR#IMR_0100610
IMR:0100597
http://purl.org/obo/owl/IMR#IMR_0100597
Binding of Cdc2 and CyclinA in cytosol
event
Binding of Cdk1 and CyclinA in cytosol
IMR:0100607
http://purl.org/obo/owl/IMR#IMR_0100607
IMR:0100597
http://purl.org/obo/owl/IMR#IMR_0100597
REACT:6308.2
http://purl.org/obo/owl/REACT#REACT_6308.2
Phosphorylation of Cdc2 by Cdk7 in cytosol
UniProt:P50613, Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive carboxyl-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
event
Phosphorylation of Cdk1 by Cdk7 in cytosol
IMR:0100597
http://purl.org/obo/owl/IMR#IMR_0100597
IMR:0100603
http://purl.org/obo/owl/IMR#IMR_0100603
Dephosphorylation Cdc2 by Cdc25C in cytosol
event
Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity.nCATALYTIC ACTIVITY: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
IMR:0100597
http://purl.org/obo/owl/IMR#IMR_0100597
REACT:6257.1
http://purl.org/obo/owl/REACT#REACT_6257.1
IMR:0100634
http://purl.org/obo/owl/IMR#IMR_0100634
Phosphorylation of Cdc2 by Wee1 in cytosol
event
IMR:0100640
http://purl.org/obo/owl/IMR#IMR_0100640
REACT:6178.2
http://purl.org/obo/owl/REACT#REACT_6178.2
IMR:0100597
http://purl.org/obo/owl/IMR#IMR_0100597
Phosphorylation of Cdk1 by Wee1 in cytosol
May act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDC2 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDC2 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDC2 occurs exclusively on Tyr-15 and phosphorylation of monomeric CDC2 does not occur.nCATALYTIC ACTIVITY: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
UniProt:P30291
http://purl.org/obo/owl/UniProt#UniProt_P30291
REACT:6327.2
http://purl.org/obo/owl/REACT#REACT_6327.2
Negative regulation of G2-M-phase transition
event
GO:0010972
http://purl.org/obo/owl/GO#GO_0010972
Any process that decreases the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle.
GO:0010972
http://purl.org/obo/owl/GO#GO_0010972
Regulation of G2-M-phase transition
event
GO:0010389
http://purl.org/obo/owl/GO#GO_0010389
Any process that modulates the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle.
GO:0010389
http://purl.org/obo/owl/GO#GO_0010389
Positive regulation of G2-M-phase transition
event
Any process that increases the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle.
GO:0010971
http://purl.org/obo/owl/GO#GO_0010971
GO:0010971
http://purl.org/obo/owl/GO#GO_0010971
TGF beta super family signaling (through p15)
event
TGF beta super family signaling pathway (through p15)
TGF beta super family signaling (through p21)
event
TGF beta super family signaling pathway (through p21)
Activation of p27 by Contact pressure in cytosol
event
IMR:0100384
http://purl.org/obo/owl/IMR#IMR_0100384
Gene expression by Smad complex
event
IMR:0000370
http://purl.org/obo/owl/IMR#IMR_0000370
Gene expression of p15 by Smad complex
event
IMR:0000370
http://purl.org/obo/owl/IMR#IMR_0000370
IMR:0701008
http://purl.org/obo/owl/IMR#IMR_0701008
Transcription by p53 in nucleus
event
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
Transcription by Smad complex in nucleus
event
IMR:0000370
http://purl.org/obo/owl/IMR#IMR_0000370
Nuclear export of mRNA (p15)
event
IMR:0701008
http://purl.org/obo/owl/IMR#IMR_0701008
Transcription of p15 by Smad complex in nucleus
event
IMR:0000370
http://purl.org/obo/owl/IMR#IMR_0000370
IMR:0701008
http://purl.org/obo/owl/IMR#IMR_0701008
Translation of p15 in cytosol
event
IMR:0701008
http://purl.org/obo/owl/IMR#IMR_0701008
TGF beta super family signaling (through p16)
event
TGF beta super family signaling pathway (through p16)
TGF beta super family signaling (through p27)
event
TGF beta super family signaling pathway (through p27)
Activation of p21 by Contact pressure in cytosol
event
IMR:0100383
http://purl.org/obo/owl/IMR#IMR_0100383
Negative regulation of G1-S-phase transition pathway by contact pressure (through p27)
event
Negative regulation of G1-S-phase transition pathway by contact pressure (through p21)
event
Translation of p16 in cytosol
event
IMR:0701007
http://purl.org/obo/owl/IMR#IMR_0701007
Gene expression of p16 by Smad complex
event
IMR:0000370
http://purl.org/obo/owl/IMR#IMR_0000370
IMR:0701007
http://purl.org/obo/owl/IMR#IMR_0701007
Nuclear export of mRNA (p16)
event
IMR:0701007
http://purl.org/obo/owl/IMR#IMR_0701007
Transcription of p16 by Smad complex in nucleus
event
IMR:0000370
http://purl.org/obo/owl/IMR#IMR_0000370
IMR:0701007
http://purl.org/obo/owl/IMR#IMR_0701007
Gene expression of p21 by Smad complex
event
IMR:0100383
http://purl.org/obo/owl/IMR#IMR_0100383
IMR:0000370
http://purl.org/obo/owl/IMR#IMR_0000370
Transcription of p21 by Smad complex in nucleus
event
IMR:0000370
http://purl.org/obo/owl/IMR#IMR_0000370
IMR:0100383
http://purl.org/obo/owl/IMR#IMR_0100383
Translation of p27 in cytosol
event
IMR:0100384
http://purl.org/obo/owl/IMR#IMR_0100384
Transcription of p27 by Smad complex in nucleus
event
IMR:0000370
http://purl.org/obo/owl/IMR#IMR_0000370
IMR:0100384
http://purl.org/obo/owl/IMR#IMR_0100384
Gene expression of p27 by Smad complex
event
IMR:0100384
http://purl.org/obo/owl/IMR#IMR_0100384
IMR:0000370
http://purl.org/obo/owl/IMR#IMR_0000370
Nuclear export of mRNA (p27)
event
IMR:0100384
http://purl.org/obo/owl/IMR#IMR_0100384
Hydrolysis of precursor Notch by convertase in Golgi
event
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
Hydrolysis in Golgi
event
Translocation of Notch from the Golgi to plasma membrane
event
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
Translocation from Golgi to plasma membrane
event
The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.
GO:0006893
http://purl.org/obo/owl/GO#GO_0006893
GO:0006893
http://purl.org/obo/owl/GO#GO_0006893
Golgi to plasma membrane transport
Golgi to plasma membrane vesicle-mediated transport
Binding of Notch and DSL ligand in extracellular
event
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
IMR:0001920
http://purl.org/obo/owl/IMR#IMR_0001920
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
Hydrolysis of Notch by ADAM in plasma membrane
event
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
near the transmembrane domain
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
IMR:0001865
http://purl.org/obo/owl/IMR#IMR_0001865
Hydrolysis of Notch by Presenilin in plasma membrane
event
within the transmembrane domain
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
IMR:0000560
http://purl.org/obo/owl/IMR#IMR_0000560
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
Nuclear import of Notch (NIC) from the plasma membrane
event
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
Binding of Notch (NIC) and CSL in inner space of nucleus
event
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
IMR:0100723
http://purl.org/obo/owl/IMR#IMR_0100723
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
Binding of Notch (NIC) and coactivator in inner space of nucleus
event
IMR:0000424
http://purl.org/obo/owl/IMR#IMR_0000424
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
Binding of Notch (NIC) and transcription factor in inner space of nucleus
event
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
GO:0007221
http://purl.org/obo/owl/GO#GO_0007221
IMR:0000368
http://purl.org/obo/owl/IMR#IMR_0000368
Dissociation of CSL and corepressor in inner space of nucleus
event
IMR:0100723
http://purl.org/obo/owl/IMR#IMR_0100723
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
IMR:0000427
http://purl.org/obo/owl/IMR#IMR_0000427
Binding of CSL and responsive element in inner space of nucleus
event
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
IMR:0100723
http://purl.org/obo/owl/IMR#IMR_0100723
IGS:0000028
http://purl.org/obo/owl/IGS#IGS_0000028
Transcription by CSL:Notch (NIC) in nucleus
event
IMR:0100723
http://purl.org/obo/owl/IMR#IMR_0100723
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
Regulation of Notch signaling pathway
event
GO:0008593
http://purl.org/obo/owl/GO#GO_0008593
Any process that modulates the frequency, rate or extent of the Notch signaling pathway.
GO:0008593
http://purl.org/obo/owl/GO#GO_0008593
Negative regulation of Notch signaling pathway
event
Any process that stops, prevents or reduces the rate, frequency or extent of the Notch signaling pathway.
GO:0045746
http://purl.org/obo/owl/GO#GO_0045746
GO:0045746
http://purl.org/obo/owl/GO#GO_0045746
Positive regulation of Notch signaling pathway
event
GO:0045747
http://purl.org/obo/owl/GO#GO_0045747
Any process that activates or increases the rate, frequency or extent of the Notch signaling pathway.
GO:0045747
http://purl.org/obo/owl/GO#GO_0045747
Binding of Notch and Delta in extracellular
event
IMR:0100718
http://purl.org/obo/owl/IMR#IMR_0100718
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
Binding of Notch1 and Jagged1 in extracellular
event
IMR:0001910
http://purl.org/obo/owl/IMR#IMR_0001910
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
IMR:0100714
http://purl.org/obo/owl/IMR#IMR_0100714
Binding of Notch1 and Fringe in Golgi
event
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
IMR:0001852
http://purl.org/obo/owl/IMR#IMR_0001852
IMR:0100714
http://purl.org/obo/owl/IMR#IMR_0100714
Binding in Golgi
event
Binding of Notch and Fringe
event
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
IMR:0001852
http://purl.org/obo/owl/IMR#IMR_0001852
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
Delta mediated Notch signaling pathway
event
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
Jagged mediated Notch signaling pathway
event
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
Regulation of Delta mediated Notch signaling pathway
event
Negative regulation of Delta mediated Notch signaling pathway
event
Positive regulation of Delta mediated Notch signaling pathway
event
Regulation of Jagged mediated Notch signaling pathway
event
Negative regulation of Jagged mediated Notch signaling pathway
event
Positive regulation of Jagged mediated Notch signaling pathway
event
Binding of Mint and CSL in inner space of nucleus
event
IMR:0001961
http://purl.org/obo/owl/IMR#IMR_0001961
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
IMR:0100723
http://purl.org/obo/owl/IMR#IMR_0100723
Activation of Deltex [Mammalian]
event
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.nOBSOLETE: remap to 'Activation of Deltex' IEV:0003541.
UniProt:Q86Y01
http://purl.org/obo/owl/UniProt#UniProt_Q86Y01
Activation of Deltex [Drosophila]
event
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it may also act as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch. May function as an ubiquitin ligase protein in the Notch pathway.nOBSOLETE: remap to 'Activation of Deltex' IEV:0003541.
UniProt:Q23985
http://purl.org/obo/owl/UniProt#UniProt_Q23985
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
Activation of Numb [Mammalian]
event
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
OBSOLETE: remap to 'Activation of Numb' IEV:0003542.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Complex formation of BCR complex and coreceptor in plasma membrane
event
Signal transduction by the BCR and coreceptor complexes is initiated by the recruitment and activation of tyrosine kinases. Upon antigen binding, membrane immunoglobulin and the Ig alpha-Ig beta heterodimer translocate to the glycolipid and cholesterol-rich membrane microdomains (lipid rafts) wherein fatty-acid-modified Src family kinases are constitutively present. Similarly, coengagement of the BCR and CD21 with multimeric C3d(g) bound to antigen promotes CD19-CD21-CD81 partitioning to the rafts, functioning to augment and potentiate signal transduction.
PubMed:15886112
http://purl.org/obo/owl/PubMed#PubMed_15886112
IMR:0000153
http://purl.org/obo/owl/IMR#IMR_0000153
PubMed:15886112
http://purl.org/obo/owl/PubMed#PubMed_15886112
BCR receptor complex and coreceptor complex formation
Actomyosin structure organization and biogenesis
event
The assembly and arrangement of cytoskeletal structures containing both actin and myosin. The myosin may be organized into filaments.
GO:0031032
http://purl.org/obo/owl/GO#GO_0031032
GO:0031032
http://purl.org/obo/owl/GO#GO_0031032
Integrin signaling pathway (through PI3K, Vav and Rac)
event
KEGG:hsa04510
http://purl.org/obo/owl/KEGG#KEGG_hsa04510
Binding of Estrogen and Estrogen receptor in inner space of nucleus
event
PubMed:15385571
http://purl.org/obo/owl/PubMed#PubMed_15385571
PubMed:11559590
http://purl.org/obo/owl/PubMed#PubMed_11559590
PubMed:17336390
http://purl.org/obo/owl/PubMed#PubMed_17336390
CHEBI:50114
http://purl.org/obo/owl/CHEBI#CHEBI_50114
IMR:0000088
http://purl.org/obo/owl/IMR#IMR_0000088
Translocation of Estrogen from extracellular to cytosol
event
PubMed:15385571
http://purl.org/obo/owl/PubMed#PubMed_15385571
CHEBI:50114
http://purl.org/obo/owl/CHEBI#CHEBI_50114
Translocation from extracellular to cytosol
event
Binding of Estrogen receptor and SWI/SNF complex in inner space of nucleus
event
IMR:0000088
http://purl.org/obo/owl/IMR#IMR_0000088
GO:0016514
http://purl.org/obo/owl/GO#GO_0016514
PubMed:11559590
http://purl.org/obo/owl/PubMed#PubMed_11559590
Nuclear import of Estrogen
event
CHEBI:50114
http://purl.org/obo/owl/CHEBI#CHEBI_50114
PubMed:15385571
http://purl.org/obo/owl/PubMed#PubMed_15385571
Complex formation of Estrogen receptor in inner space of nucleus
event
PubMed:17336390
http://purl.org/obo/owl/PubMed#PubMed_17336390
PubMed:15385571
http://purl.org/obo/owl/PubMed#PubMed_15385571
IMR:0000088
http://purl.org/obo/owl/IMR#IMR_0000088
Estrogen receptor complex formation
Binding of Estrogen receptor and responsive element in inner space of nucleus
event
IGS:0000028
http://purl.org/obo/owl/IGS#IGS_0000028
IMR:0000088
http://purl.org/obo/owl/IMR#IMR_0000088
PubMed:11559590
http://purl.org/obo/owl/PubMed#PubMed_11559590
Binding of Estrogen receptor and transcription factor in inner space of nucleus
event
IMR:0000088
http://purl.org/obo/owl/IMR#IMR_0000088
PubMed:11559590
http://purl.org/obo/owl/PubMed#PubMed_11559590
IMR:0000368
http://purl.org/obo/owl/IMR#IMR_0000368
Binding of Estrogen receptor and p160 coactivator in inner space of nucleus
event
IMR:0000088
http://purl.org/obo/owl/IMR#IMR_0000088
PubMed:11559590
http://purl.org/obo/owl/PubMed#PubMed_11559590
Binding of Estrogen receptor and cyclin D1 in inner space of nucleus
event
PubMed:11559590
http://purl.org/obo/owl/PubMed#PubMed_11559590
IMR:0000088
http://purl.org/obo/owl/IMR#IMR_0000088
IMR:0100615
http://purl.org/obo/owl/IMR#IMR_0100615
Binding of Estrogen receptor and MTA-1 in inner space of nucleus
event
IMR:0000088
http://purl.org/obo/owl/IMR#IMR_0000088
PubMed:11559590
http://purl.org/obo/owl/PubMed#PubMed_11559590
UniProt:Q13330
http://purl.org/obo/owl/UniProt#UniProt_Q13330
Binding of Estrogen receptor and corepressor in inner space of nucleus
event
PubMed:11559590
http://purl.org/obo/owl/PubMed#PubMed_11559590
IMR:0000427
http://purl.org/obo/owl/IMR#IMR_0000427
IMR:0000088
http://purl.org/obo/owl/IMR#IMR_0000088
Binding of Estrogen receptor and NCOR1 in inner space of nucleus
event
UniProt:O75376
http://purl.org/obo/owl/UniProt#UniProt_O75376
IMR:0000088
http://purl.org/obo/owl/IMR#IMR_0000088
PubMed:11559590
http://purl.org/obo/owl/PubMed#PubMed_11559590
Binding of Estrogen receptor and NCOR2 in inner space of nucleus
event
IMR:0000088
http://purl.org/obo/owl/IMR#IMR_0000088
UniProt:Q9Y618
http://purl.org/obo/owl/UniProt#UniProt_Q9Y618
PubMed:11559590
http://purl.org/obo/owl/PubMed#PubMed_11559590
Transcription factor complex formation with Estrogen receptor in inner space of nucleus
event
IMR:0000088
http://purl.org/obo/owl/IMR#IMR_0000088
PubMed:11136970
http://purl.org/obo/owl/PubMed#PubMed_11136970
PubMed:11559590
http://purl.org/obo/owl/PubMed#PubMed_11559590
PubMed:12040178
http://purl.org/obo/owl/PubMed#PubMed_12040178
Binding of Transcription factor complex and CBP in inner space of nucleus
event
IMR:0001404
http://purl.org/obo/owl/IMR#IMR_0001404
PubMed:11559590
http://purl.org/obo/owl/PubMed#PubMed_11559590
IMR:0000368
http://purl.org/obo/owl/IMR#IMR_0000368
Binding of Transcription factor complex and HDAC in inner space of nucleus
event
IMR:0001166
http://purl.org/obo/owl/IMR#IMR_0001166
PubMed:11559590
http://purl.org/obo/owl/PubMed#PubMed_11559590
IMR:0000368
http://purl.org/obo/owl/IMR#IMR_0000368
Binding of Transcription factor complex and pCAF in inner space of nucleus
event
IMR:0000368
http://purl.org/obo/owl/IMR#IMR_0000368
UniProt:Q92831
http://purl.org/obo/owl/UniProt#UniProt_Q92831
PubMed:11559590
http://purl.org/obo/owl/PubMed#PubMed_11559590
Binding of Transcription factor complex and p300 in inner space of nucleus
event
IMR:0000368
http://purl.org/obo/owl/IMR#IMR_0000368
PubMed:11559590
http://purl.org/obo/owl/PubMed#PubMed_11559590
IMR:0001405
http://purl.org/obo/owl/IMR#IMR_0001405
Binding of Transcription factor complex and HAT in inner space of nucleus
event
PubMed:11559590
http://purl.org/obo/owl/PubMed#PubMed_11559590
IMR:0001176
http://purl.org/obo/owl/IMR#IMR_0001176
IMR:0000368
http://purl.org/obo/owl/IMR#IMR_0000368
Transcription by Estrogen receptor in nucleus
event
PubMed:11559590
http://purl.org/obo/owl/PubMed#PubMed_11559590
IMR:0000088
http://purl.org/obo/owl/IMR#IMR_0000088
Src activation signaling
event
Binding of Src and Estrogen receptor beta:MNAR
event
IMR:0700224
http://purl.org/obo/owl/IMR#IMR_0700224
IMR:0100575
http://purl.org/obo/owl/IMR#IMR_0100575
PubMed:12415108
http://purl.org/obo/owl/PubMed#PubMed_12415108
Binding of Estrogen receptor and MNAR
event
UniProt:Q8IZL8
http://purl.org/obo/owl/UniProt#UniProt_Q8IZL8
PubMed:12415108
http://purl.org/obo/owl/PubMed#PubMed_12415108
IMR:0000088
http://purl.org/obo/owl/IMR#IMR_0000088
Binding of Estrogen receptor alpha and MNAR
event
IMR:0700220
http://purl.org/obo/owl/IMR#IMR_0700220
UniProt:Q8IZL8
http://purl.org/obo/owl/UniProt#UniProt_Q8IZL8
PubMed:12415108
http://purl.org/obo/owl/PubMed#PubMed_12415108
Binding of Estrogen receptor beta and MNAR
event
IMR:0700224
http://purl.org/obo/owl/IMR#IMR_0700224
UniProt:Q8IZL8
http://purl.org/obo/owl/UniProt#UniProt_Q8IZL8
PubMed:12415108
http://purl.org/obo/owl/PubMed#PubMed_12415108
PI3K activation signaling
event
Binding of Estrogen receptor alpha and p85 in cytosol
event
IMR:0700220
http://purl.org/obo/owl/IMR#IMR_0700220
PubMed:11029009
http://purl.org/obo/owl/PubMed#PubMed_11029009
IMR:0000266
http://purl.org/obo/owl/IMR#IMR_0000266
Binding of Estrogen and Estrogen receptor alpha in inner space of nucleus
event
IMR:0700220
http://purl.org/obo/owl/IMR#IMR_0700220
CHEBI:50114
http://purl.org/obo/owl/CHEBI#CHEBI_50114
PubMed:11559590
http://purl.org/obo/owl/PubMed#PubMed_11559590
Binding of Estrogen and Estrogen receptor beta in inner space of nucleus
event
CHEBI:50114
http://purl.org/obo/owl/CHEBI#CHEBI_50114
IMR:0700224
http://purl.org/obo/owl/IMR#IMR_0700224
PubMed:11559590
http://purl.org/obo/owl/PubMed#PubMed_11559590
Steroid receptor signaling pathway
event
Any series of molecular signals generated as a consequence of a steroid hormone binding to its receptor.
GO:0030518
http://purl.org/obo/owl/GO#GO_0030518
steroid hormone receptor signaling pathway
GO:0030518
http://purl.org/obo/owl/GO#GO_0030518
Androgen receptor signaling pathway
event
GO:0030521
http://purl.org/obo/owl/GO#GO_0030521
Any series of molecular signals generated as a consequence of an androgen binding to its receptor.
GO:0030521
http://purl.org/obo/owl/GO#GO_0030521
TPO signaling pathway (JAK2, STAT3)
event
TPO signaling pathway (through Sos, Ras and Erk cascade)
event
TPO signaling pathway (through PI3K, PLCgamma and PKC)
event
Binding of Glutamate and NMDA receptor
event
IMR:0000083
http://purl.org/obo/owl/IMR#IMR_0000083
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
PubMed:12536131
http://purl.org/obo/owl/PubMed#PubMed_12536131
PubMed:14556714
http://purl.org/obo/owl/PubMed#PubMed_14556714
Binding of Glutamate and AMPA receptor
event
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
PubMed:14556714
http://purl.org/obo/owl/PubMed#PubMed_14556714
Translocation of sodium ion from extracellular to cytosol (through AMPA receptor)
event
PubMed:14556714
http://purl.org/obo/owl/PubMed#PubMed_14556714
KEGG:C01330
http://purl.org/obo/owl/KEGG#KEGG_C01330
Changes in polarization state of the membrane
event
Depolarization state of the postsynaptic cell
event
PubMed:14556714
http://purl.org/obo/owl/PubMed#PubMed_14556714
Changes in polarization state of postsynaptic cell membrane
event
Dissociation of magnesium ion and NMDA receptor in plasma membrane
event
KEGG:C00305
http://purl.org/obo/owl/KEGG#KEGG_C00305
IMR:0000083
http://purl.org/obo/owl/IMR#IMR_0000083
PubMed:14556714
http://purl.org/obo/owl/PubMed#PubMed_14556714
Translocation of calcium and sodium ion from extracellular to cytosol (through NMDA receptor)
event
PubMed:14556714
http://purl.org/obo/owl/PubMed#PubMed_14556714
IMR:0100031
http://purl.org/obo/owl/IMR#IMR_0100031
KEGG:C01330
http://purl.org/obo/owl/KEGG#KEGG_C01330
Long-Term Potentiation
event
KEGG:hsa04720
http://purl.org/obo/owl/KEGG#KEGG_hsa04720
PubMed:14556714
http://purl.org/obo/owl/PubMed#PubMed_14556714
Binding of calcium ion and calmodulin in cytosol
event
IMR:0000457
http://purl.org/obo/owl/IMR#IMR_0000457
IMR:0100031
http://purl.org/obo/owl/IMR#IMR_0100031
PubMed:14556714
http://purl.org/obo/owl/PubMed#PubMed_14556714
Cytosolic calcium ion concentration elevation
event
elevation of cytosolic calcium ion concentration
GO:0007204
http://purl.org/obo/owl/GO#GO_0007204
GO:0007204
http://purl.org/obo/owl/GO#GO_0007204
elevation of calcium ion concentration in cytosol
GO:0007204
http://purl.org/obo/owl/GO#GO_0007204
Any process that increases the concentration of calcium ions in the cytosol.
GO:0007204
http://purl.org/obo/owl/GO#GO_0007204
Cytosolic calcium ion concentration elevation (through Glutamate receptor)
event
PubMed:14556714
http://purl.org/obo/owl/PubMed#PubMed_14556714
Binding of calcium calmodulin and CaMKII in cytosol
event
IMR:0100548
http://purl.org/obo/owl/IMR#IMR_0100548
IMR:0100031
http://purl.org/obo/owl/IMR#IMR_0100031
IMR:0000457
http://purl.org/obo/owl/IMR#IMR_0000457
PubMed:14556714
http://purl.org/obo/owl/PubMed#PubMed_14556714
Cytosolic cation ion concentration decline (through cGMP activated cation ion channel)
event
Translocation of calcium ion from the cytosol to the extracellular
event
IMR:0100031
http://purl.org/obo/owl/IMR#IMR_0100031
Translocation from cytosol to extracellular
event
Binding of TCR-CD3 complex and non-receptor tyrosine kinase in cytosol
event
IMR:0002372
http://purl.org/obo/owl/IMR#IMR_0002372
IMR:0000682
http://purl.org/obo/owl/IMR#IMR_0000682
Phosphorylation of CD3 zeta by non-receptor tyrosine kinase in cytosol
event
PubMed:12040176
http://purl.org/obo/owl/PubMed#PubMed_12040176
IMR:0100287
http://purl.org/obo/owl/IMR#IMR_0100287
IMR:0000682
http://purl.org/obo/owl/IMR#IMR_0000682
Notch receptor processing
event
The series of successive proteolytic cleavage events that take place after a Notch receptor binds a ligand, and which lead to the release of the Notch Intracellular Domain (NICD), which is the active form of the receptor.
GO:0007220
http://purl.org/obo/owl/GO#GO_0007220
PubMed:14985712
http://purl.org/obo/owl/PubMed#PubMed_14985712
GO:0007220
http://purl.org/obo/owl/GO#GO_0007220
Receptor recycling
event
GO:0001881
http://purl.org/obo/owl/GO#GO_0001881
The process by which receptor molecules are returned to an active state and in an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal.
GO:0001881
http://purl.org/obo/owl/GO#GO_0001881
PDGF receptor signaling pathway
event
GO:0048008
http://purl.org/obo/owl/GO#GO_0048008
PDGF signaling pathway
GO:0048008
http://purl.org/obo/owl/GO#GO_0048008
The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
GO:0048008
http://purl.org/obo/owl/GO#GO_0048008
platelet-derived growth factor receptor signaling pathway
GO:0048008
http://purl.org/obo/owl/GO#GO_0048008
PDGFR signaling pathway
GO:0048008
http://purl.org/obo/owl/GO#GO_0048008
Ras mediated signaling
event
Ras mediated signal transduction
GO:0007265
http://purl.org/obo/owl/GO#GO_0007265
GO:0007265
http://purl.org/obo/owl/GO#GO_0007265
Ras protein signal transduction
GO:0007265
http://purl.org/obo/owl/GO#GO_0007265
A series of molecular signals within the cell that are mediated by a member of the Ras family of proteins switching to a GTP-bound active state.
GO:0007265
http://purl.org/obo/owl/GO#GO_0007265
Rac mediated signaling
event
Rac protein signal transduction
GO:0016601
http://purl.org/obo/owl/GO#GO_0016601
A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state.
GO:0016601
http://purl.org/obo/owl/GO#GO_0016601
Rac mediated signal transduction
GO:0016601
http://purl.org/obo/owl/GO#GO_0016601
GO:0016601
http://purl.org/obo/owl/GO#GO_0016601
Rho mediated signaling
event
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
GO:0007266
http://purl.org/obo/owl/GO#GO_0007266
GO:0007266
http://purl.org/obo/owl/GO#GO_0007266
Rho protein signal transduction
GO:0007266
http://purl.org/obo/owl/GO#GO_0007266
Rho mediated signal transduction
GO:0007266
http://purl.org/obo/owl/GO#GO_0007266
Rho-p160-myosin phosphatase signaling
event
KEGG:rno04810
http://purl.org/obo/owl/KEGG#KEGG_rno04810
KEGG:hsa04510
http://purl.org/obo/owl/KEGG#KEGG_hsa04510
KEGG:mmu04810
http://purl.org/obo/owl/KEGG#KEGG_mmu04810
KEGG:hsa04810
http://purl.org/obo/owl/KEGG#KEGG_hsa04810
Rho-PI5K signaling
event
KEGG:hsa04510
http://purl.org/obo/owl/KEGG#KEGG_hsa04510
Ral mediated signaling
event
GO:0032484
http://purl.org/obo/owl/GO#GO_0032484
A series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state.
GO:0032484
http://purl.org/obo/owl/GO#GO_0032484
Ral protein signal transduction
I-kappaB degradation signaling
event
Regulation of IKK-NF-kappaB signaling
event
regulation of I-kappaB kinase/NF-kappaB cascade
Any process that modulates an I-kappaB kinase/NF-kappaB induced cascade.
GO:0043122
http://purl.org/obo/owl/GO#GO_0043122
GO:0043122
http://purl.org/obo/owl/GO#GO_0043122
Negative regulation of IKK-NF-kappaB signaling
event
Any process that stops, prevents or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade.
GO:0043124
http://purl.org/obo/owl/GO#GO_0043124
downregulation of I-kappaB kinase/NF-kappaB cascade
negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043124
http://purl.org/obo/owl/GO#GO_0043124
Positive regulation of IKK-NF-kappaB signaling
event
positive regulation of I-kappaB kinase/NF-kappaB cascade
upregulation of I-kappaB kinase/NF-kappaB cascade
GO:0043123
http://purl.org/obo/owl/GO#GO_0043123
Any process that activates or increases the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade.
GO:0043123
http://purl.org/obo/owl/GO#GO_0043123
Phosphorylation of STAT by MAPK in cytosol
event
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
IMR:0000224
http://purl.org/obo/owl/IMR#IMR_0000224
GO:0042501
http://purl.org/obo/owl/GO#GO_0042501
Complex formation of BCR in plasma membrane
event
BCR complex formation
PubMed:15886112
http://purl.org/obo/owl/PubMed#PubMed_15886112
IMR:0000153
http://purl.org/obo/owl/IMR#IMR_0000153
Complex formation of B cell coreceptor in plasma membrane
event
PubMed:15886112
http://purl.org/obo/owl/PubMed#PubMed_15886112
The B cell coreceptor complex, which is defined by its ability to bind and respond to C3d(g)-bound antigen, is composed of CD19, CD21 and the widely expressed CD81 and Leu13 proteins.n
PubMed:15886112
http://purl.org/obo/owl/PubMed#PubMed_15886112
B cell coreceptor complex formation
Regulation of B cell receptor signaling
event
Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
GO:0050855
http://purl.org/obo/owl/GO#GO_0050855
Regulation of B cell receptor signaling pathway
GO:0050855
http://purl.org/obo/owl/GO#GO_0050855
Negative regulation of B cell receptor signaling
event
GO:0050859
http://purl.org/obo/owl/GO#GO_0050859
Any process that stops, prevents or reduces the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
GO:0050859
http://purl.org/obo/owl/GO#GO_0050859
Negative regulation of B cell receptor signaling pathway
Positive regulation of B cell receptor signaling
event
Any process that activates or increases the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
GO:0050861
http://purl.org/obo/owl/GO#GO_0050861
Positive regulation of B cell receptor signaling pathway
GO:0050861
http://purl.org/obo/owl/GO#GO_0050861
Negative regulation of B cell receptor signaling (through CD72 and SHP-1)
event
IMR:0000275
http://purl.org/obo/owl/IMR#IMR_0000275
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
Complex formation of IgM and Ig alpha:beta in plasma membrane
event
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
IgM and Ig alpha:beta complex formation
IMR:0000154
http://purl.org/obo/owl/IMR#IMR_0000154
IMR:0000155
http://purl.org/obo/owl/IMR#IMR_0000155
Binding of antigen and BCR complex in extracellular
event
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
IMR:0000465
http://purl.org/obo/owl/IMR#IMR_0000465
IMR:0000153
http://purl.org/obo/owl/IMR#IMR_0000153
Phosphorylation of Ig alpha:beta by non-receptor tyrosine kinase in cytosol
event
The immunoglobulin (Ig) and Ig cytoplasmic tails are phosphorylated on the immunoreceptor tyrosine-based activation motif (ITAM) tyrosines by Src-family tyrosine kinases (SFTKs) and/or Syk.
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
IMR:0000155
http://purl.org/obo/owl/IMR#IMR_0000155
IMR:0000682
http://purl.org/obo/owl/IMR#IMR_0000682
Phosphorylation of Ig alpha:beta by Lyn in cytosol
event
IMR:0000211
http://purl.org/obo/owl/IMR#IMR_0000211
IMR:0000155
http://purl.org/obo/owl/IMR#IMR_0000155
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
Phosphorylation of Ig alpha:beta by Syk in cytosol
event
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
IMR:0000155
http://purl.org/obo/owl/IMR#IMR_0000155
IMR:0000222
http://purl.org/obo/owl/IMR#IMR_0000222
Phosphorylation of Ig alpha:beta by Src family in cytosol
event
IMR:0000211
http://purl.org/obo/owl/IMR#IMR_0000211
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
IMR:0000155
http://purl.org/obo/owl/IMR#IMR_0000155
Binding of Ig alpha and Syk in cytosol
event
IMR:0000222
http://purl.org/obo/owl/IMR#IMR_0000222
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
IMR:0100541
http://purl.org/obo/owl/IMR#IMR_0100541
he B-cell linker protein (BLNK) binds to tyrosine 204 of Ig alpha.
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
Binding of Ig alpha and BLNK in cytosol
event
IMR:0100541
http://purl.org/obo/owl/IMR#IMR_0100541
IMR:0000353
http://purl.org/obo/owl/IMR#IMR_0000353
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
Binding of BLNK and BtK in cytosol
event
IMR:0000215
http://purl.org/obo/owl/IMR#IMR_0000215
IMR:0000353
http://purl.org/obo/owl/IMR#IMR_0000353
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
Binding of BLNK and PLC gamma in cytosol
event
IMR:0000285
http://purl.org/obo/owl/IMR#IMR_0000285
IMR:0000353
http://purl.org/obo/owl/IMR#IMR_0000353
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
Binding of tyrosine-phosphorylated protein and PLC in cytosol
event
IMR:0000284
http://purl.org/obo/owl/IMR#IMR_0000284
IMR:0000949
http://purl.org/obo/owl/IMR#IMR_0000949
Phosphorylation of PLC by non-receptor tyrosine kinase in cytosol
event
IMR:0000682
http://purl.org/obo/owl/IMR#IMR_0000682
IMR:0000284
http://purl.org/obo/owl/IMR#IMR_0000284
Binding of DAG and PKC theta and active conformational change of PKC theta in cytosol
event
PubMed:15343367
http://purl.org/obo/owl/PubMed#PubMed_15343367
IMR:0100484
http://purl.org/obo/owl/IMR#IMR_0100484
IMR:0100027
http://purl.org/obo/owl/IMR#IMR_0100027
Phosphorylation of PLC gamma by Btk in cytosol
event
IMR:0000215
http://purl.org/obo/owl/IMR#IMR_0000215
IMR:0000285
http://purl.org/obo/owl/IMR#IMR_0000285
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
Binding of tyrosine-phosphorylated protein and PLC gamma in cytosol
event
IMR:0000285
http://purl.org/obo/owl/IMR#IMR_0000285
IMR:0000949
http://purl.org/obo/owl/IMR#IMR_0000949
Phosphorylation of Ig alpha:beta by Fyn in cytosol
event
IMR:0000155
http://purl.org/obo/owl/IMR#IMR_0000155
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
IMR:0100352
http://purl.org/obo/owl/IMR#IMR_0100352
Phosphorylation of Ig alpha:beta by Blk in cytosol
event
IMR:0000155
http://purl.org/obo/owl/IMR#IMR_0000155
UniProt:P51451
http://purl.org/obo/owl/UniProt#UniProt_P51451
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
event
B cell receptor signaling pathway (through PLC gamma, calcineurin and NF-AT)
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
B cell receptor signaling (through Ras and ERK cascade)
event
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
B cell receptor signaling pathway (through Ras and ERK cascade)
B cell receptor signaling (through Vav and Rac)
event
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
B cell receptor signaling pathway (through Vav and Rac)
Binding of BLNK and Grb2 in cytosol
event
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
IMR:0000353
http://purl.org/obo/owl/IMR#IMR_0000353
IMR:0000340
http://purl.org/obo/owl/IMR#IMR_0000340
B cell receptor signaling (through IKK-NF-kappaB cascade)
event
B cell receptor signaling pathway (through IKK-NF-kappaB cascade)
Binding of BLNK and Vav in cytosol
event
IMR:0000434
http://purl.org/obo/owl/IMR#IMR_0000434
IMR:0000353
http://purl.org/obo/owl/IMR#IMR_0000353
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
Rac activation signaling
event
Small GTPase activation signaling
event
Calcium ion dependent protein activation signaling
event
Calcineurin activation signaling
event
CaMKII activation signaling
event
Binding of calcium calmodulin and calcineurin in cytosol
event
IMR:0000278
http://purl.org/obo/owl/IMR#IMR_0000278
IMR:0000457
http://purl.org/obo/owl/IMR#IMR_0000457
IMR:0100031
http://purl.org/obo/owl/IMR#IMR_0100031
Binding of calcium ion and calcineurin in cytosol
event
IMR:0100031
http://purl.org/obo/owl/IMR#IMR_0100031
IMR:0000278
http://purl.org/obo/owl/IMR#IMR_0000278
Activation of NF-kappaB by Src family in cytosol
event
NF-kappaB activation
IMR:0000211
http://purl.org/obo/owl/IMR#IMR_0000211
PubMed:14632637
http://purl.org/obo/owl/PubMed#PubMed_14632637
IMR:0000382
http://purl.org/obo/owl/IMR#IMR_0000382
Transcription by NF-kappaB in nucleus
event
IMR:0000382
http://purl.org/obo/owl/IMR#IMR_0000382
Dephosphorylation of NF-AT by calcineurin in cytosol
event
IMR:0000278
http://purl.org/obo/owl/IMR#IMR_0000278
IMR:0000421
http://purl.org/obo/owl/IMR#IMR_0000421
Nuclear import of NF-AT
event
GO:0051531
http://purl.org/obo/owl/GO#GO_0051531
The directed movement of NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors, from the cytoplasm into the nucleus. NFAT proteins are dephosphorylated in the cytoplasm by activated calcineurin, which leads to their translocation across the nuclear membrane.
GO:0051531
http://purl.org/obo/owl/GO#GO_0051531
IMR:0000421
http://purl.org/obo/owl/IMR#IMR_0000421
NFAT protein import into nucleus
NFAT protein nuclear translocation
NFAT protein nucleus import
NFAT protein transport from cytoplasm to nucleus
Nuclear import of calcineurin
event
IMR:0000278
http://purl.org/obo/owl/IMR#IMR_0000278
Transcription by NF-AT in nucleus
event
IMR:0000421
http://purl.org/obo/owl/IMR#IMR_0000421
Src activation signaling (through Estrogen receptor)
event
PubMed:12415108
http://purl.org/obo/owl/PubMed#PubMed_12415108
Lymphocyte differentiation
event
The process whereby a relatively unspecialized precursor cell acquires specialized features of B-cells, T-cells, or natural killer cells.
GO:0030098
http://purl.org/obo/owl/GO#GO_0030098
GO:0030098
http://purl.org/obo/owl/GO#GO_0030098
Lymphocyte proliferation
event
The rapid expansion of a lymphocyte population by cell division.
GO:0046651
http://purl.org/obo/owl/GO#GO_0046651
GO:0046651
http://purl.org/obo/owl/GO#GO_0046651
G2 phase
event
Progression through G2 phase, one of two 'gap' phases in the cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis).
GO:0051319
http://purl.org/obo/owl/GO#GO_0051319
GO:D016195
http://purl.org/obo/owl/GO#GO_D016195
GO:0051319
http://purl.org/obo/owl/GO#GO_0051319
Cell communication
event
Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
GO:0007154
http://purl.org/obo/owl/GO#GO_0007154
GO:0007154
http://purl.org/obo/owl/GO#GO_0007154
Cellular component organization
event
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
GO:0016043
http://purl.org/obo/owl/GO#GO_0016043
GO:0016043
http://purl.org/obo/owl/GO#GO_0016043
cell component organization and biogenesis
GO:0016043
http://purl.org/obo/owl/GO#GO_0016043
cell organisation
Cytoplasm organization
event
GO:0007028
http://purl.org/obo/owl/GO#GO_0007028
cytoplasm organisation
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0007028
http://purl.org/obo/owl/GO#GO_0007028
Organelle organization
event
GO:0006996
http://purl.org/obo/owl/GO#GO_0006996
organelle organisation
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GO:0006996
http://purl.org/obo/owl/GO#GO_0006996
Actin cytoskeleton organization and biogenesis
event
GO:0030036
http://purl.org/obo/owl/GO#GO_0030036
The assembly and arrangement of cytoskeletal structures comprising actin filaments and their associated proteins.
GO:0030036
http://purl.org/obo/owl/GO#GO_0030036
Actin filament organization
event
GO:0007015
http://purl.org/obo/owl/GO#GO_0007015
Control of the spatial distribution of actin filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
GO:0007015
http://purl.org/obo/owl/GO#GO_0007015
Cell morphogenesis
event
The developmental process by which the size or shape of a cell is generated and organized. Morphogenesis pertains to the creation of form.
GO:0000902
http://purl.org/obo/owl/GO#GO_0000902
GO:0000902
http://purl.org/obo/owl/GO#GO_0000902
cellular morphogenesis
Permeabilization of mitochondria and Translocation of AIF from mitochondria to cytosol
event
UniProt:O95831
http://purl.org/obo/owl/UniProt#UniProt_O95831
Multicellular organismal process
event
Organismal physiological process
GO:0050874
http://purl.org/obo/owl/GO#GO_0050874
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
GO:0032501
http://purl.org/obo/owl/GO#GO_0032501
GO:0032501
http://purl.org/obo/owl/GO#GO_0032501
Rhythmic behavior
event
GO:0007622
http://purl.org/obo/owl/GO#GO_0007622
The specific actions or reactions of an organism that recur with measured regularity.
GO:0007622
http://purl.org/obo/owl/GO#GO_0007622
Seed development
event
Processes aimed at the progression of the seed over time, from its formation to the mature structure. A seed is a propagating organ formed in the sexual reproductive cycle of gymnosperms and angiosperms, consisting of a protective coat enclosing an embryo and food reserves.
GO:0048316
http://purl.org/obo/owl/GO#GO_0048316
GO:0048316
http://purl.org/obo/owl/GO#GO_0048316
Physiological event
event
Homeostasis
event
homeostatic process
GO:0042592
http://purl.org/obo/owl/GO#GO_0042592
Response to stimulus
event
A change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of a stimulus.
GO:0050896
http://purl.org/obo/owl/GO#GO_0050896
GO:0050896
http://purl.org/obo/owl/GO#GO_0050896
Response to biotic stimulus
event
A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of a biotic stimulus.
GO:0009607
http://purl.org/obo/owl/GO#GO_0009607
GO:0009607
http://purl.org/obo/owl/GO#GO_0009607
Response to endogenous stimulus
event
GO:0009719
http://purl.org/obo/owl/GO#GO_0009719
A change in state or activity of a cell or an organism as a result of the perception of an endogenous stimulus.
GO:0009719
http://purl.org/obo/owl/GO#GO_0009719
Response to external stimulus
event
A change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of an external stimulus.
GO:0009605
http://purl.org/obo/owl/GO#GO_0009605
GO:0009605
http://purl.org/obo/owl/GO#GO_0009605
Response to stress
event
A change in state or activity of an organism or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) that occurs in response to stress, usually, but not necessarily exogenous (e.g. temperature, humidity, ionizing radiation).
GO:0006950
http://purl.org/obo/owl/GO#GO_0006950
GO:0006950
http://purl.org/obo/owl/GO#GO_0006950
Flower formation
event
The process that gives rise to the flower. This process pertains to the initial formation of a structure from unspecified parts.
GO:0048460
http://purl.org/obo/owl/GO#GO_0048460
GO:0048460
http://purl.org/obo/owl/GO#GO_0048460
Wood development
IEV:0000395
event
Wood formation
Bud development
IEV:0000399
event
Bud formation
Response to wounding
event
A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of damage to the organism.
GO:0009611
http://purl.org/obo/owl/GO#GO_0009611
GO:0009611
http://purl.org/obo/owl/GO#GO_0009611
Wound healing
event
GO:0042060
http://purl.org/obo/owl/GO#GO_0042060
The series of events that restore integrity to a damaged tissue, following an injury.
GO:0042060
http://purl.org/obo/owl/GO#GO_0042060
Binding of IL-2 and IL-2 receptor and conformational change of receptors in plasma membrane
event
IMR:0000008
http://purl.org/obo/owl/IMR#IMR_0000008
GO:0004911
http://purl.org/obo/owl/GO#GO_0004911
GO:0005134
http://purl.org/obo/owl/GO#GO_0005134
Combining with interleukin-2 to initiate a change in cell activity.
GO:0004911
http://purl.org/obo/owl/GO#GO_0004911
PubMed:10920190
http://purl.org/obo/owl/PubMed#PubMed_10920190
IMR:0000097
http://purl.org/obo/owl/IMR#IMR_0000097
Binding of IL3 and IL3 receptor and conformational change of receptors in plasma membrane
event
Combining with interleukin-3 to initiate a change in cell activity.
GO:0004912
http://purl.org/obo/owl/GO#GO_0004912
IMR:0000109
http://purl.org/obo/owl/IMR#IMR_0000109
IMR:0000012
http://purl.org/obo/owl/IMR#IMR_0000012
GO:0005135
http://purl.org/obo/owl/GO#GO_0005135
GO:0004912
http://purl.org/obo/owl/GO#GO_0004912
Binding of IL4 and IL4 receptor and conformational change of receptors in plasma membrane
event
IMR:0000585
http://purl.org/obo/owl/IMR#IMR_0000585
GO:0004913
http://purl.org/obo/owl/GO#GO_0004913
IMR:0000107
http://purl.org/obo/owl/IMR#IMR_0000107
GO:0005136
http://purl.org/obo/owl/GO#GO_0005136
Combining with interleukin-4 to initiate a change in cell activity.
GO:0004913
http://purl.org/obo/owl/GO#GO_0004913
Binding of IL-12 and IL-12 receptor and conformational change of receptors in plasma membrane
event
Combining with interleukin-12 to initiate a change in cell activity.
GO:0016517
http://purl.org/obo/owl/GO#GO_0016517
IMR:0000602
http://purl.org/obo/owl/IMR#IMR_0000602
IMR:0000590
http://purl.org/obo/owl/IMR#IMR_0000590
GO:0016517
http://purl.org/obo/owl/GO#GO_0016517
GO:0005143
http://purl.org/obo/owl/GO#GO_0005143
PubMed:12805384
http://purl.org/obo/owl/PubMed#PubMed_12805384
Binding of IL-10 and IL-10 receptor and conformational change of receptors in plasma membrane
event
GO:0004920
http://purl.org/obo/owl/GO#GO_0004920
GO:0005141
http://purl.org/obo/owl/GO#GO_0005141
Combining with interleukin-10 to initiate a change in cell activity.
GO:0004920
http://purl.org/obo/owl/GO#GO_0004920
PubMed:12626585
http://purl.org/obo/owl/PubMed#PubMed_12626585
IMR:0000589
http://purl.org/obo/owl/IMR#IMR_0000589
IMR:0000608
http://purl.org/obo/owl/IMR#IMR_0000608
Phosphorylation of EGFR by PKC in cytosol
event
IMR:0000245
http://purl.org/obo/owl/IMR#IMR_0000245
PubMed:15567847
http://purl.org/obo/owl/PubMed#PubMed_15567847
PKC then phosphorylates and regulates the activity of many proteins, including EGFR; phosphorylation of a threonine residue (Thr654) in the juxtamembrane domain modulates EGF binding affinity and kinase activity of the EGFR.
PubMed:15567847
http://purl.org/obo/owl/PubMed#PubMed_15567847
IMR:0000081
http://purl.org/obo/owl/IMR#IMR_0000081
Regulation of EGF signaling pathway
event
Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
GO:0042058
http://purl.org/obo/owl/GO#GO_0042058
GO:0042058
http://purl.org/obo/owl/GO#GO_0042058
regulation of EGF receptor signaling pathway
GO:0042058
http://purl.org/obo/owl/GO#GO_0042058
regulation of EGFR signaling pathway
GO:0042058
http://purl.org/obo/owl/GO#GO_0042058
regulation of epidermal growth factor receptor signaling pathway
GO:0042058
http://purl.org/obo/owl/GO#GO_0042058
Negative regulation of EGF receptor signaling pathway
event
GO:0042059
http://purl.org/obo/owl/GO#GO_0042059
Any process that stops, prevents or reduces the rate, frequency or extent of epidermal growth factor receptor signaling pathway activity.
GO:0042059
http://purl.org/obo/owl/GO#GO_0042059
Positive regulation of EGF signaling pathway
event
Any process that activates or increases the rate, frequency or extent of epidermal growth factor receptor signaling pathway activity.
GO:0045742
http://purl.org/obo/owl/GO#GO_0045742
GO:0045742
http://purl.org/obo/owl/GO#GO_0045742
Tyrosine biosynthesis
event
tyrosine synthesis
tyrosine formation
KEGG:map00400
http://purl.org/obo/owl/KEGG#KEGG_map00400
The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.
GO:0006571
http://purl.org/obo/owl/GO#GO_0006571
tyrosine biosynthetic process
tyrosine anabolism
GO:0006571
http://purl.org/obo/owl/GO#GO_0006571
Activation of c-Raf1 by PKC beta in cytosol
event
IMR:0001146
http://purl.org/obo/owl/IMR#IMR_0001146
IMR:0100355
http://purl.org/obo/owl/IMR#IMR_0100355
cPKCs (a and b1) have the potential to activate c-Raf1 in vivo while at the same time blocking further activation by growth factors and other PKC isotypes.
PubMed:9447975
http://purl.org/obo/owl/PubMed#PubMed_9447975
PubMed:9447975
http://purl.org/obo/owl/PubMed#PubMed_9447975
Activation of Raf1 by Ras-GTP along with PKC alpha in cytosol
event
IMR:0001145
http://purl.org/obo/owl/IMR#IMR_0001145
IMR:0000290
http://purl.org/obo/owl/IMR#IMR_0000290
IMR:0100355
http://purl.org/obo/owl/IMR#IMR_0100355
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
PubMed:12417593
http://purl.org/obo/owl/PubMed#PubMed_12417593
Raf activation signaling (through RKIP)
event
Protein kinase C (PKC) regulates activation of the Raf-1 signaling cascade by growth factors, but the mechanism by which this occurs has not been elucidated. Here we report that one mechanism involves dissociation of Raf kinase inhibitory protein (RKIP) from Raf-1. Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153).
PubMed:12551925
http://purl.org/obo/owl/PubMed#PubMed_12551925
PubMed:12551925
http://purl.org/obo/owl/PubMed#PubMed_12551925
Phosphorylation of RKIP by PKC in cytosol
event
PubMed:12551925
http://purl.org/obo/owl/PubMed#PubMed_12551925
UniProt:P30086
http://purl.org/obo/owl/UniProt#UniProt_P30086
IMR:0000245
http://purl.org/obo/owl/IMR#IMR_0000245
Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153).
PubMed:12551925
http://purl.org/obo/owl/PubMed#PubMed_12551925
Dissociation of RKIP and Raf1 in cytosol
event
PubMed:12551925
http://purl.org/obo/owl/PubMed#PubMed_12551925
IMR:0100355
http://purl.org/obo/owl/IMR#IMR_0100355
UniProt:P30086
http://purl.org/obo/owl/UniProt#UniProt_P30086
Protein kinase C (PKC) regulates activation of the Raf-1 signaling cascade by growth factors, but the mechanism by which this occurs has not been elucidated. Here we report that one mechanism involves dissociation of Raf kinase inhibitory protein (RKIP) from Raf-1.
PubMed:12551925
http://purl.org/obo/owl/PubMed#PubMed_12551925
Phosphorylation of RKIP by cPKC in cytosol
event
PubMed:12551925
http://purl.org/obo/owl/PubMed#PubMed_12551925
IMR:0100486
http://purl.org/obo/owl/IMR#IMR_0100486
Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153).
PubMed:12551925
http://purl.org/obo/owl/PubMed#PubMed_12551925
UniProt:P30086
http://purl.org/obo/owl/UniProt#UniProt_P30086
Phosphorylation of RKIP by aPKC in cytosol
event
UniProt:P30086
http://purl.org/obo/owl/UniProt#UniProt_P30086
PubMed:12551925
http://purl.org/obo/owl/PubMed#PubMed_12551925
Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153).
PubMed:12551925
http://purl.org/obo/owl/PubMed#PubMed_12551925
IMR:0000247
http://purl.org/obo/owl/IMR#IMR_0000247
Activation of c-Raf1 by PKC alpha in cytosol
event
IMR:0100355
http://purl.org/obo/owl/IMR#IMR_0100355
IMR:0001145
http://purl.org/obo/owl/IMR#IMR_0001145
PubMed:9447975
http://purl.org/obo/owl/PubMed#PubMed_9447975
cPKCs (a and b1) have the potential to activate c-Raf1 in vivo while at the same time blocking further activation by growth factors and other PKC isotypes.
PubMed:9447975
http://purl.org/obo/owl/PubMed#PubMed_9447975
Activation of Raf by PKC in cytosol
event
IMR:0000231
http://purl.org/obo/owl/IMR#IMR_0000231
IMR:0000245
http://purl.org/obo/owl/IMR#IMR_0000245
Activation of c-Raf1 by PKC eta in cytosol
event
IMR:0001150
http://purl.org/obo/owl/IMR#IMR_0001150
PubMed:9447975
http://purl.org/obo/owl/PubMed#PubMed_9447975
IMR:0100355
http://purl.org/obo/owl/IMR#IMR_0100355
At the level of Raf, the kinase that phosphorylates MEK-1, the activation cascade diverges; while conventional and novel PKCs (isotypes a and h) are potent activators of c-Raf1, atypical PKC-z cannot increase c-Raf1 activity,stimulating MEK by an independent mechanism.
PubMed:9447975
http://purl.org/obo/owl/PubMed#PubMed_9447975
Raf activation signaling (through PKC)
event
Binding of PLC gamma1 and PIP3 in cytosol
event
PubMed:15343367
http://purl.org/obo/owl/PubMed#PubMed_15343367
IMR:0001352
http://purl.org/obo/owl/IMR#IMR_0001352
IMR:0000732
http://purl.org/obo/owl/IMR#IMR_0000732
Hydrolysis of PIP2 by PLC gamma1 to generate DAG and IP3 in cytosol
event
PubMed:15343367
http://purl.org/obo/owl/PubMed#PubMed_15343367
IMR:0100028
http://purl.org/obo/owl/IMR#IMR_0100028
IMR:0001350
http://purl.org/obo/owl/IMR#IMR_0001350
IMR:0000732
http://purl.org/obo/owl/IMR#IMR_0000732
IMR:0100027
http://purl.org/obo/owl/IMR#IMR_0100027
Binding of LAT_p and PLC gamma1 in cytosol
event
IMR:0000732
http://purl.org/obo/owl/IMR#IMR_0000732
IMR:0000348
http://purl.org/obo/owl/IMR#IMR_0000348
PubMed:12040176
http://purl.org/obo/owl/PubMed#PubMed_12040176
PubMed:15343367
http://purl.org/obo/owl/PubMed#PubMed_15343367
Phosphorylation of Vav by ZAP-70 in cytosol
event
IMR:0000221
http://purl.org/obo/owl/IMR#IMR_0000221
PubMed:15343367
http://purl.org/obo/owl/PubMed#PubMed_15343367
IMR:0000434
http://purl.org/obo/owl/IMR#IMR_0000434
Binding of SLP-76 and Vav in cytosol
event
PubMed:12040176
http://purl.org/obo/owl/PubMed#PubMed_12040176
PubMed:15343367
http://purl.org/obo/owl/PubMed#PubMed_15343367
IMR:0000350
http://purl.org/obo/owl/IMR#IMR_0000350
IMR:0000434
http://purl.org/obo/owl/IMR#IMR_0000434
Binding of SLP-76 and Nck in cytosol
event
IMR:0000343
http://purl.org/obo/owl/IMR#IMR_0000343
IMR:0000350
http://purl.org/obo/owl/IMR#IMR_0000350
PubMed:12040176
http://purl.org/obo/owl/PubMed#PubMed_12040176
PubMed:15343367
http://purl.org/obo/owl/PubMed#PubMed_15343367
Binding of Nck and PAK in cytosol
event
PubMed:15343367
http://purl.org/obo/owl/PubMed#PubMed_15343367
PubMed:12040176
http://purl.org/obo/owl/PubMed#PubMed_12040176
IMR:0000343
http://purl.org/obo/owl/IMR#IMR_0000343
IMR:0000238
http://purl.org/obo/owl/IMR#IMR_0000238
Activation of IKK beta by PKC theta in cytosol
event
IMR:0100484
http://purl.org/obo/owl/IMR#IMR_0100484
IMR:0100459
http://purl.org/obo/owl/IMR#IMR_0100459
PubMed:10733597
http://purl.org/obo/owl/PubMed#PubMed_10733597
T-cell lines expressing constitutively active PKC-theta, but not other constitutively active PKCs (alpha, delta, epsilon or zeta), were capable of activating an NF-kB reporter. Co-transfection experiments indicated that constitutively active PKC-theta upregulates the activity of IKKbeta, but not IKKalpha. Although a biochemical association between PKC-theta and IKKbeta could not be detected, the data suggest that PKC-theta directly or indirectly modulates IKKbeta kinase activity, thus regulating NF-kB.
PubMed:10733597
http://purl.org/obo/owl/PubMed#PubMed_10733597
Phosphorylation of IKK complex by NIK in cytosol
event
TNRF signaling
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
GO:0007250
http://purl.org/obo/owl/GO#GO_0007250
IMR:0000243
http://purl.org/obo/owl/IMR#IMR_0000243
IMR:0000242
http://purl.org/obo/owl/IMR#IMR_0000242
Regulation of T cell receptor signaling pathway
event
GO:0050856
http://purl.org/obo/owl/GO#GO_0050856
Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
GO:0050856
http://purl.org/obo/owl/GO#GO_0050856
Negative regulation of T cell receptor signaling pathway
event
Any process that stops, prevents or reduces the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
GO:0050860
http://purl.org/obo/owl/GO#GO_0050860
GO:0050860
http://purl.org/obo/owl/GO#GO_0050860
Positive regulation of T cell receptor signaling pathway
event
Any process that activates or increases the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
GO:0050862
http://purl.org/obo/owl/GO#GO_0050862
GO:0050862
http://purl.org/obo/owl/GO#GO_0050862
Transcription of IL-2 by NF-kappaB in nucleus
event
IMR:0000382
http://purl.org/obo/owl/IMR#IMR_0000382
PubMed:11973130
http://purl.org/obo/owl/PubMed#PubMed_11973130
IMR:0000008
http://purl.org/obo/owl/IMR#IMR_0000008
Phosphorylation of IKK beta by TAK1 in cytosol
event
PubMed:15125833
http://purl.org/obo/owl/PubMed#PubMed_15125833
IMR:0100459
http://purl.org/obo/owl/IMR#IMR_0100459
IMR:0000232
http://purl.org/obo/owl/IMR#IMR_0000232
IKK activation signaling
event
Oligomerization of MALT1 in cytosol
event
PubMed:15125833
http://purl.org/obo/owl/PubMed#PubMed_15125833
IMR:0002662
http://purl.org/obo/owl/IMR#IMR_0002662
Oligomerization of TRAF6 in cytosol
event
IMR:0100427
http://purl.org/obo/owl/IMR#IMR_0100427
PubMed:15125833
http://purl.org/obo/owl/PubMed#PubMed_15125833
Binding of MALT1 and TRAF6 in cytosol
event
IMR:0002662
http://purl.org/obo/owl/IMR#IMR_0002662
IMR:0100427
http://purl.org/obo/owl/IMR#IMR_0100427
PubMed:15125833
http://purl.org/obo/owl/PubMed#PubMed_15125833
Binding of BCL10 and MALT1 in cytosol
event
IMR:0002662
http://purl.org/obo/owl/IMR#IMR_0002662
PubMed:15125833
http://purl.org/obo/owl/PubMed#PubMed_15125833
IMR:0002658
http://purl.org/obo/owl/IMR#IMR_0002658
Activation of TAK1 by ubiquitinated TRAF6 in cytosol
event
PubMed:15125833
http://purl.org/obo/owl/PubMed#PubMed_15125833
IMR:0100427
http://purl.org/obo/owl/IMR#IMR_0100427
IMR:0000232
http://purl.org/obo/owl/IMR#IMR_0000232
Recruitment of CARMA1 and BCL10 to the lipid raft of the synapse by PKC theta
event
IMR:0002655
http://purl.org/obo/owl/IMR#IMR_0002655
IMR:0002658
http://purl.org/obo/owl/IMR#IMR_0002658
IMR:0100484
http://purl.org/obo/owl/IMR#IMR_0100484
PubMed:15125833
http://purl.org/obo/owl/PubMed#PubMed_15125833
Recruitment to the raft
event
IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)
event
Ubiquitination of TRAF6 by TRAF6 in cytosol
event
PubMed:15125833
http://purl.org/obo/owl/PubMed#PubMed_15125833
IMR:0100427
http://purl.org/obo/owl/IMR#IMR_0100427
Ubiquitination of NEMO by TRAF6 in cytosol
event
IMR:0100427
http://purl.org/obo/owl/IMR#IMR_0100427
PubMed:15125833
http://purl.org/obo/owl/PubMed#PubMed_15125833
IMR:0001164
http://purl.org/obo/owl/IMR#IMR_0001164
Autophosphorylation of TAK1 in cytosol
event
IMR:0000232
http://purl.org/obo/owl/IMR#IMR_0000232
PubMed:15125833
http://purl.org/obo/owl/PubMed#PubMed_15125833
PKC theta activation signaling
event
PubMed:15343367
http://purl.org/obo/owl/PubMed#PubMed_15343367
cPKC activation signaling
event
Binding of calcium ion and cPKC and active conformational change of cPKC in cytosol
event
PubMed:7499357
http://purl.org/obo/owl/PubMed#PubMed_7499357
PubMed:10506570
http://purl.org/obo/owl/PubMed#PubMed_10506570
IMR:0100486
http://purl.org/obo/owl/IMR#IMR_0100486
IMR:0100031
http://purl.org/obo/owl/IMR#IMR_0100031
Binding of DAG and cPKC and active conformational change of cPKC in cytosol
event
PubMed:7499357
http://purl.org/obo/owl/PubMed#PubMed_7499357
IMR:0100486
http://purl.org/obo/owl/IMR#IMR_0100486
IMR:0100027
http://purl.org/obo/owl/IMR#IMR_0100027
Binding of DAG, calcium ion and cPKC and active conformational change of cPKC in cytosol
event
IMR:0100027
http://purl.org/obo/owl/IMR#IMR_0100027
IMR:0100031
http://purl.org/obo/owl/IMR#IMR_0100031
IMR:0100486
http://purl.org/obo/owl/IMR#IMR_0100486
PubMed:7499357
http://purl.org/obo/owl/PubMed#PubMed_7499357
Activation of MEKK3 by RIP1 in cytosol
event
IMR:0700610
http://purl.org/obo/owl/IMR#IMR_0700610
IMR:0100451
http://purl.org/obo/owl/IMR#IMR_0100451
Fas signaling pathway
event
KEGG:mmu04210
http://purl.org/obo/owl/KEGG#KEGG_mmu04210
KEGG:hsa04210
http://purl.org/obo/owl/KEGG#KEGG_hsa04210
REACT:900.1
http://purl.org/obo/owl/REACT#REACT_900.1
KEGG:rno04210
http://purl.org/obo/owl/KEGG#KEGG_rno04210
Nuclear export of mRNA (Smad7)
event
IMR:0100318
http://purl.org/obo/owl/IMR#IMR_0100318
Binding of Smad7 and TGF beta receptor I in cytosol
event
IMR:0000710
http://purl.org/obo/owl/IMR#IMR_0000710
IMR:0100318
http://purl.org/obo/owl/IMR#IMR_0100318
Regulation of Toll-like receptor pathway
event
Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway.
GO:0034121
http://purl.org/obo/owl/GO#GO_0034121
GO:0034121
http://purl.org/obo/owl/GO#GO_0034121
regulation of TLR signaling pathway
Regulation of Ras mediated signaling
event
regulation of Ras protein signal transduction
GO:0046578
http://purl.org/obo/owl/GO#GO_0046578
Any process that modulates the frequency, rate or extent of Ras protein signal transduction.
GO:0046578
http://purl.org/obo/owl/GO#GO_0046578
GO:0046578
http://purl.org/obo/owl/GO#GO_0046578
Positive regulation of Ras mediated signaling
event
Any process that activates or increases the rate, frequency or extent of Ras protein signal transduction.
GO:0046579
http://purl.org/obo/owl/GO#GO_0046579
positive regulation of Ras protein signal transduction
GO:0046579
http://purl.org/obo/owl/GO#GO_0046579
GO:0046579
http://purl.org/obo/owl/GO#GO_0046579
Regulation of cell cycle process
event
Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
GO:0010564
http://purl.org/obo/owl/GO#GO_0010564
GO:0010564
http://purl.org/obo/owl/GO#GO_0010564
Negative regulation of cell cycle process
event
Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
GO:0010948
http://purl.org/obo/owl/GO#GO_0010948
GO:0010948
http://purl.org/obo/owl/GO#GO_0010948
Positive regulation of cell cycle process
event
GO:0090068
http://purl.org/obo/owl/GO#GO_0090068
Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
GO:0090068
http://purl.org/obo/owl/GO#GO_0090068
Regulation of PDGF signaling pathway
event
Regulation of PLC signaling
event
Negative regulation of PLC signaling
event
Positive regulation of PLC signaling
event
Alanine and aspartate metabolism
event
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
GO:0006531
http://purl.org/obo/owl/GO#GO_0006531
GO:0006522
http://purl.org/obo/owl/GO#GO_0006522
Alanine metabolism: The chemical reactions and pathways involving alanine, 2-aminopropanoic acid. nAspartate metabolism: The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
GO:0006522
http://purl.org/obo/owl/GO#GO_0006522
GO:0006531
http://purl.org/obo/owl/GO#GO_0006531
Glutamate metabolism
event
The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.
GO:0006536
http://purl.org/obo/owl/GO#GO_0006536
GO:0006536
http://purl.org/obo/owl/GO#GO_0006536
glutamic acid metabolic process
glutamic acid metabolism
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
glutamate metabolic process
Glycine, serine and threonine metabolism
event
GO:0006544
http://purl.org/obo/owl/GO#GO_0006544
GO:0006563
http://purl.org/obo/owl/GO#GO_0006563
Glycine metabolism: The chemical reactions and pathways involving glycine, aminoethanoic acid. nSerine metabolism: The chemical reactions and pathways involving L-serine, the levorotatory isomer of 2-amino-3-hydroxypropanoic acid. nThreonine metabolism: The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.
GO:0006566
http://purl.org/obo/owl/GO#GO_0006566
GO:0006563
http://purl.org/obo/owl/GO#GO_0006563
GO:0006544
http://purl.org/obo/owl/GO#GO_0006544
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
GO:0006566
http://purl.org/obo/owl/GO#GO_0006566
Glycolysis and Gluconeogenesis
event
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
GO:0006096
http://purl.org/obo/owl/GO#GO_0006096
Glycolysis: The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) in other compounds, including pyruvate.nGluconeogenesis: The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
GO:0006096
http://purl.org/obo/owl/GO#GO_0006096
GO:0006094
http://purl.org/obo/owl/GO#GO_0006094
GO:0006094
http://purl.org/obo/owl/GO#GO_0006094
Pentose phosphate pathway
event
The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses.
GO:0006098
http://purl.org/obo/owl/GO#GO_0006098
GO:0006098
http://purl.org/obo/owl/GO#GO_0006098
KEGG:map00030
http://purl.org/obo/owl/KEGG#KEGG_map00030
pentose-phosphate shunt
pentose phosphate shunt
pentose-phosphate pathway
hexose monophosphate pathway
Citrate cycle (TCA cycle)
event
GO:0006099
http://purl.org/obo/owl/GO#GO_0006099
tricarboxylic acid cycle
KEGG:map00020
http://purl.org/obo/owl/KEGG#KEGG_map00020
Krebs cycle
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two C02 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
GO:0006099
http://purl.org/obo/owl/GO#GO_0006099
citric acid cycle
Pentose and glucuronate interconversions
event
KEGG:map00040
http://purl.org/obo/owl/KEGG#KEGG_map00040
Fructose and mannose metabolism
event
Fructose metabolism: The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.nMannose metabolism: The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.
GO:0006013
http://purl.org/obo/owl/GO#GO_0006013
GO:0006000
http://purl.org/obo/owl/GO#GO_0006000
KEGG:map00051
http://purl.org/obo/owl/KEGG#KEGG_map00051
GO:0006013
http://purl.org/obo/owl/GO#GO_0006013
GO:0006000
http://purl.org/obo/owl/GO#GO_0006000
Galactose metabolism
event
KEGG:map00052
http://purl.org/obo/owl/KEGG#KEGG_map00052
galactose metabolic process
The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
GO:0006012
http://purl.org/obo/owl/GO#GO_0006012
GO:0006012
http://purl.org/obo/owl/GO#GO_0006012
Ascorbate and aldarate metabolism
event
GO:0019852
http://purl.org/obo/owl/GO#GO_0019852
KEGG:map00053
http://purl.org/obo/owl/KEGG#KEGG_map00053
Ascorbate metabolism: The chemical reactions and pathways involving L-ascorbic acid, a carbohydrate-like vitamin containing six carbon atoms per molecule. Widely distributed in fruit and vegetables.
GO:0019852
http://purl.org/obo/owl/GO#GO_0019852
Starch and sucrose metabolism
event
Starch metabolism: The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose.nSucrose metabolism: The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside.
GO:0005985
http://purl.org/obo/owl/GO#GO_0005985
GO:0005982
http://purl.org/obo/owl/GO#GO_0005982
GO:0005982
http://purl.org/obo/owl/GO#GO_0005982
GO:0005985
http://purl.org/obo/owl/GO#GO_0005985
KEGG:map00500
http://purl.org/obo/owl/KEGG#KEGG_map00500
Aminosugars metabolism
event
GO:0006040
http://purl.org/obo/owl/GO#GO_0006040
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
aminosaccharide metabolism
amino sugar metabolic process
amino sugar metabolism
The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group.
GO:0006040
http://purl.org/obo/owl/GO#GO_0006040
aminosaccharide metabolic process
Carbohydrate Metabolism
event
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
GO:0005975
http://purl.org/obo/owl/GO#GO_0005975
carbohydrate metabolic process
GO:0005975
http://purl.org/obo/owl/GO#GO_0005975
Nucleotide sugars metabolism
event
The chemical reactions and pathways involving nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.
GO:0009225
http://purl.org/obo/owl/GO#GO_0009225
GO:0009225
http://purl.org/obo/owl/GO#GO_0009225
nucleotide-sugar metabolic process
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
Pyruvate metabolism
event
KEGG:map00620
http://purl.org/obo/owl/KEGG#KEGG_map00620
GO:0006090
http://purl.org/obo/owl/GO#GO_0006090
pyruvate metabolic process
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
GO:0006090
http://purl.org/obo/owl/GO#GO_0006090
Glyoxylate and dicarboxylate metabolism
event
Glyoxylate metabolism: The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH. nDicarboxylate metabolism: The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-).
GO:0043648
http://purl.org/obo/owl/GO#GO_0043648
GO:0046487
http://purl.org/obo/owl/GO#GO_0046487
KEGG:map00630
http://purl.org/obo/owl/KEGG#KEGG_map00630
GO:0043648
http://purl.org/obo/owl/GO#GO_0043648
GO:0046487
http://purl.org/obo/owl/GO#GO_0046487
Propanoate metabolism
event
KEGG:map00640
http://purl.org/obo/owl/KEGG#KEGG_map00640
Butanoate metabolism
event
KEGG:map00650
http://purl.org/obo/owl/KEGG#KEGG_map00650
C5-Branched dibasic acid metabolism
event
KEGG:map00660
http://purl.org/obo/owl/KEGG#KEGG_map00660
Inositol metabolism
event
vitamin Bh metabolism
inositol metabolic process
The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.
GO:0006020
http://purl.org/obo/owl/GO#GO_0006020
GO:0006020
http://purl.org/obo/owl/GO#GO_0006020
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
vitamin Bh metabolic process
Inositol phosphate metabolism
event
The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
GO:0043647
http://purl.org/obo/owl/GO#GO_0043647
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
GO:0043647
http://purl.org/obo/owl/GO#GO_0043647
inositol phosphate metabolic process
Oxidative phosphorylation
event
The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.
GO:0006119
http://purl.org/obo/owl/GO#GO_0006119
GO:0006119
http://purl.org/obo/owl/GO#GO_0006119
KEGG:map00190
http://purl.org/obo/owl/KEGG#KEGG_map00190
respiratory-chain phosphorylation
ATP synthesis
event
ATP formation
The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0006754
http://purl.org/obo/owl/GO#GO_0006754
GO:0006754
http://purl.org/obo/owl/GO#GO_0006754
ATP anabolism
ATP biosynthetic process
ATP biosynthesis
Photosynthesis
event
The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds.
GO:0015979
http://purl.org/obo/owl/GO#GO_0015979
KEGG:map00195
http://purl.org/obo/owl/KEGG#KEGG_map00195
GO:0015979
http://purl.org/obo/owl/GO#GO_0015979
Carbon fixation
event
KEGG:map00710
http://purl.org/obo/owl/KEGG#KEGG_map00710
Reductive carboxylate cycle (CO2 fixation)
event
KEGG:map00720
http://purl.org/obo/owl/KEGG#KEGG_map00720
Methane metabolism
event
KEGG:map00680
http://purl.org/obo/owl/KEGG#KEGG_map00680
The chemical reactions and pathways involving methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes.
GO:0015947
http://purl.org/obo/owl/GO#GO_0015947
methane metabolic process
GO:0015947
http://purl.org/obo/owl/GO#GO_0015947
Nitrogen metabolism
event
KEGG:map00910
http://purl.org/obo/owl/KEGG#KEGG_map00910
Sulfur metabolism
event
KEGG:map00920
http://purl.org/obo/owl/KEGG#KEGG_map00920
GO:0006790
http://purl.org/obo/owl/GO#GO_0006790
sulphur metabolic process
sulfur metabolic process
sulphur metabolism
The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
GO:0006790
http://purl.org/obo/owl/GO#GO_0006790
Fatty acid biosynthesis
event
fatty acid synthesis
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
GO:0006633
http://purl.org/obo/owl/GO#GO_0006633
KEGG:map00061
http://purl.org/obo/owl/KEGG#KEGG_map00061
fatty acid anabolism
GO:0006633
http://purl.org/obo/owl/GO#GO_0006633
fatty acid biosynthetic process
fatty acid formation
Fatty acid elongation in mitochondria
event
GO:0030497
http://purl.org/obo/owl/GO#GO_0030497
Fatty acid elongation: The elongation of a fatty acid chain by the sequential addition of two-carbon units.
GO:0030497
http://purl.org/obo/owl/GO#GO_0030497
KEGG:map00062
http://purl.org/obo/owl/KEGG#KEGG_map00062
Fatty acid metabolism
event
fatty acid metabolic process
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
GO:0006631
http://purl.org/obo/owl/GO#GO_0006631
GO:0006631
http://purl.org/obo/owl/GO#GO_0006631
KEGG:map00071
http://purl.org/obo/owl/KEGG#KEGG_map00071
Ketone bodies metabolism
event
KEGG:map00072
http://purl.org/obo/owl/KEGG#KEGG_map00072
ketone body metabolic process
The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism.
GO:0046950
http://purl.org/obo/owl/GO#GO_0046950
GO:0046950
http://purl.org/obo/owl/GO#GO_0046950
Steroid biosynthesis
event
GO:0006694
http://purl.org/obo/owl/GO#GO_0006694
KEGG:map00100
http://purl.org/obo/owl/KEGG#KEGG_map00100
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
GO:0006694
http://purl.org/obo/owl/GO#GO_0006694
steroid synthesis
steroid formation
steroidogenesis
steroid biosynthetic process
steroid anabolism
Bile acid biosynthesis
event
bile acid synthesis
The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
GO:0006699
http://purl.org/obo/owl/GO#GO_0006699
bile acid formation
bile acid biosynthetic process
bile acid anabolism
KEGG:map00120
http://purl.org/obo/owl/KEGG#KEGG_map00120
GO:0006699
http://purl.org/obo/owl/GO#GO_0006699
C21-Steroid hormone metabolism
event
C21-steroid hormone metabolic process
KEGG:map00140
http://purl.org/obo/owl/KEGG#KEGG_map00140
GO:0008207
http://purl.org/obo/owl/GO#GO_0008207
The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.
GO:0008207
http://purl.org/obo/owl/GO#GO_0008207
Steroid hormone biosynthesis
event
KEGG:map00140
http://purl.org/obo/owl/KEGG#KEGG_map00140
Glycerolipid metabolism
event
KEGG:map00561
http://purl.org/obo/owl/KEGG#KEGG_map00561
GO:0046486
http://purl.org/obo/owl/GO#GO_0046486
The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis.
GO:0046486
http://purl.org/obo/owl/GO#GO_0046486
glycerolipid metabolic process
Glycerophospholipid metabolism
event
phosphoglyceride metabolism
glycerophospholipid metabolic process
The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
GO:0006650
http://purl.org/obo/owl/GO#GO_0006650
phosphoglyceride metabolic process
GO:0006650
http://purl.org/obo/owl/GO#GO_0006650
KEGG:map00564
http://purl.org/obo/owl/KEGG#KEGG_map00564
Arachidonic acid metabolism
Prostaglandin and leukotriene metabolism
event
The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.
GO:0019369
http://purl.org/obo/owl/GO#GO_0019369
GO:0019369
http://purl.org/obo/owl/GO#GO_0019369
KEGG:map00590
http://purl.org/obo/owl/KEGG#KEGG_map00590
Purine metabolism
event
GO:0006163
http://purl.org/obo/owl/GO#GO_0006163
The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.
GO:0006163
http://purl.org/obo/owl/GO#GO_0006163
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
purine nucleotide metabolism
Pyrimidine metabolism
event
pyrimidine nucleotide metabolism
The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.
GO:0006220
http://purl.org/obo/owl/GO#GO_0006220
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
GO:0006220
http://purl.org/obo/owl/GO#GO_0006220
Valine, leucine and isoleucine degradation
event
Valine degradation: The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid. nLeucine degradation: The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid. nIsoleucine degradation: The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
GO:0006550
http://purl.org/obo/owl/GO#GO_0006550
GO:0006574
http://purl.org/obo/owl/GO#GO_0006574
GO:0006552
http://purl.org/obo/owl/GO#GO_0006552
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
GO:0006574
http://purl.org/obo/owl/GO#GO_0006574
GO:0006550
http://purl.org/obo/owl/GO#GO_0006550
GO:0006552
http://purl.org/obo/owl/GO#GO_0006552
Valine, leucine and isoleucine biosynthesis
event
Valine biosynthesis: The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid. nLeucine biosynthesis: The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid. nIsoleucine biosynthesis: The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
GO:0009097
http://purl.org/obo/owl/GO#GO_0009097
GO:0009098
http://purl.org/obo/owl/GO#GO_0009098
GO:0009099
http://purl.org/obo/owl/GO#GO_0009099
KEGG:map00290
http://purl.org/obo/owl/KEGG#KEGG_map00290
GO:0009099
http://purl.org/obo/owl/GO#GO_0009099
GO:0009098
http://purl.org/obo/owl/GO#GO_0009098
GO:0009097
http://purl.org/obo/owl/GO#GO_0009097
Lysine biosynthesis
event
KEGG:map00300
http://purl.org/obo/owl/KEGG#KEGG_map00300
GO:0009085
http://purl.org/obo/owl/GO#GO_0009085
lysine biosynthetic process
lysine anabolism
lysine formation
lysine synthesis
The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid.
GO:0009085
http://purl.org/obo/owl/GO#GO_0009085
Lysine degradation
event
KEGG:map00310
http://purl.org/obo/owl/KEGG#KEGG_map00310
lysine catabolism
The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid.
GO:0006554
http://purl.org/obo/owl/GO#GO_0006554
lysine breakdown
lysine catabolic process
GO:0006554
http://purl.org/obo/owl/GO#GO_0006554
Arginine and proline metabolism
event
GO:0006560
http://purl.org/obo/owl/GO#GO_0006560
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
GO:0006525
http://purl.org/obo/owl/GO#GO_0006525
Arginine metabolism: The chemical reactions and pathways involving arginine, 2-amino-5-guanidinopentanoic acid. Proline metabolism: The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
GO:0006525
http://purl.org/obo/owl/GO#GO_0006525
GO:0006560
http://purl.org/obo/owl/GO#GO_0006560
Histidine metabolism
event
histidine metabolic process
GO:0006547
http://purl.org/obo/owl/GO#GO_0006547
KEGG:map00340
http://purl.org/obo/owl/KEGG#KEGG_map00340
The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
GO:0006547
http://purl.org/obo/owl/GO#GO_0006547
Tyrosine metabolism
event
tyrosine metabolic process
The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.
GO:0006570
http://purl.org/obo/owl/GO#GO_0006570
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
GO:0006570
http://purl.org/obo/owl/GO#GO_0006570
Phenylalanine metabolism
event
KEGG:map00360
http://purl.org/obo/owl/KEGG#KEGG_map00360
GO:0006558
http://purl.org/obo/owl/GO#GO_0006558
L-phenylalanine metabolism: The chemical reactions and pathways involving L-phenylalanine, the levorotatory isomer of 2-amino-3-phenylpropanoic acid.
GO:0006558
http://purl.org/obo/owl/GO#GO_0006558
Tryptophan metabolism
event
The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.
GO:0006568
http://purl.org/obo/owl/GO#GO_0006568
tryptophan metabolic process
GO:0006568
http://purl.org/obo/owl/GO#GO_0006568
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
Phenylalanine biosynthesis
IEV:0000410
event
L-phenylalanine biosynthesis: The chemical reactions and pathways resulting in the formation of L-phenylalanine, the levorotatory isomer of 2-amino-3-phenylpropanoic acid.
GO:0009094
http://purl.org/obo/owl/GO#GO_0009094
Phenylalanine biosynthesis pathway
GO:0009094
http://purl.org/obo/owl/GO#GO_0009094
KEGG:map00400
http://purl.org/obo/owl/KEGG#KEGG_map00400
Urea cycle and metabolism of amino groups
event
A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea. n
GO:0000050
http://purl.org/obo/owl/GO#GO_0000050
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
GO:0000050
http://purl.org/obo/owl/GO#GO_0000050
beta-Alanine metabolism
event
The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.
GO:0019482
http://purl.org/obo/owl/GO#GO_0019482
GO:0019482
http://purl.org/obo/owl/GO#GO_0019482
beta-alanine metabolic process
KEGG:map00410
http://purl.org/obo/owl/KEGG#KEGG_map00410
Methionine and Cysteine metabolism
IEV:0001453
IEV:0001452
event
GO:0006534
http://purl.org/obo/owl/GO#GO_0006534
Methionine metabolism: The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.nCysteine metabolism: The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid.
GO:0006555
http://purl.org/obo/owl/GO#GO_0006555
GO:0006534
http://purl.org/obo/owl/GO#GO_0006534
GO:0006555
http://purl.org/obo/owl/GO#GO_0006555
KEGG:map00270
http://purl.org/obo/owl/KEGG#KEGG_map00270
KEGG:map00430
http://purl.org/obo/owl/KEGG#KEGG_map00430
Aminophosphonate metabolism
event
The chemical reactions and pathways involving aminophosphonates, amino acid derivatives that contain a phosphonic acid moiety.
GO:0033051
http://purl.org/obo/owl/GO#GO_0033051
GO:0033051
http://purl.org/obo/owl/GO#GO_0033051
aminophosphonate metabolic process
Selenoamino acid metabolism
event
KEGG:map00450
http://purl.org/obo/owl/KEGG#KEGG_map00450
Cyanoamino acid metabolism
event
The chemical reactions and pathways involving cyanoamino acids, amino acid derivatives that contain a cyanide group.
GO:0033052
http://purl.org/obo/owl/GO#GO_0033052
KEGG:map00460
http://purl.org/obo/owl/KEGG#KEGG_map00460
GO:0033052
http://purl.org/obo/owl/GO#GO_0033052
cyanoamino acid metabolic process
D-Glutamine and D-glutamate metabolism
event
KEGG:map00471
http://purl.org/obo/owl/KEGG#KEGG_map00471
GO:0033054
http://purl.org/obo/owl/GO#GO_0033054
GO:0033053
http://purl.org/obo/owl/GO#GO_0033053
D-glutamine metabolism:The chemical reactions and pathways involving D-glutamine, the D-enantiomer of the amino acid glutamine, i.e. (2R)-2,5-diamino-5-oxopentanoic acid.nD-glutamate metabolism:The chemical reactions and pathways involving D-glutamate, the D-enantiomer of the amino acid glutamate, i.e. (2R)-2-aminopentanedioic acid.
GO:0033054
http://purl.org/obo/owl/GO#GO_0033054
GO:0033053
http://purl.org/obo/owl/GO#GO_0033053
D-Arginine and D-ornithine metabolism
event
D-arginine metabolism:The chemical reactions and pathways involving D-arginine, the D-enantiomer of the amino acid arginine, i.e. (2R)-2-amino-5-(carbamimidamido)pentanoic acid.nD-ornithine metabolism:The chemical reactions and pathways involving D-ornithine, the D-enantiomer of the amino acid ornithine, i.e. (2R)-2,5-diaminopentanoic acid.
GO:0033055
http://purl.org/obo/owl/GO#GO_0033055
GO:0033056
http://purl.org/obo/owl/GO#GO_0033056
GO:0033055
http://purl.org/obo/owl/GO#GO_0033055
KEGG:map00472
http://purl.org/obo/owl/KEGG#KEGG_map00472
GO:0033056
http://purl.org/obo/owl/GO#GO_0033056
D-Alanine metabolism
event
GO:0046436
http://purl.org/obo/owl/GO#GO_0046436
KEGG:map00473
http://purl.org/obo/owl/KEGG#KEGG_map00473
The chemical reactions and pathways involving D-alanine, the dextrorotatory isomer of the amino acid alanine.
GO:0046436
http://purl.org/obo/owl/GO#GO_0046436
D-alanine metabolic process
Glutathione metabolism
event
KEGG:map00480
http://purl.org/obo/owl/KEGG#KEGG_map00480
glutathione metabolic process
GO:0006749
http://purl.org/obo/owl/GO#GO_0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
GO:0006749
http://purl.org/obo/owl/GO#GO_0006749
N-Glycan biosynthesis
event
KEGG:map00510
http://purl.org/obo/owl/KEGG#KEGG_map00510
High-mannose type N-glycan biosynthesis
event
KEGG:map00513
http://purl.org/obo/owl/KEGG#KEGG_map00513
N-Glycan degradation
event
KEGG:map00511
http://purl.org/obo/owl/KEGG#KEGG_map00511
O-Glycan biosynthesis
event
KEGG:map00512
http://purl.org/obo/owl/KEGG#KEGG_map00512
Chondroitin sulfate biosynthesis
event
The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.
GO:0030206
http://purl.org/obo/owl/GO#GO_0030206
chondroitin sulfate formation
chondroitin sulfate synthesis
chondroitin sulfate anabolism
chondroitin sulfate biosynthetic process
chondroitin sulphate biosynthesis
GO:0030206
http://purl.org/obo/owl/GO#GO_0030206
KEGG:map00532
http://purl.org/obo/owl/KEGG#KEGG_map00532
CD28 signaling
event
CD28 Costimulation
PubMed:12121659
http://purl.org/obo/owl/PubMed#PubMed_12121659
PubMed:12121659
http://purl.org/obo/owl/PubMed#PubMed_12121659
Phosphorylation of CD28 by Src family in cytosol
event
IMR:0000211
http://purl.org/obo/owl/IMR#IMR_0000211
PubMed:12121659
http://purl.org/obo/owl/PubMed#PubMed_12121659
IMR:0000473
http://purl.org/obo/owl/IMR#IMR_0000473
Phosphorylation of CD28 by Lck in cytosol
event
PubMed:12121659
http://purl.org/obo/owl/PubMed#PubMed_12121659
IMR:0100353
http://purl.org/obo/owl/IMR#IMR_0100353
IMR:0000473
http://purl.org/obo/owl/IMR#IMR_0000473
Phosphorylation of CD28 by Fyn in cytosol
event
IMR:0000473
http://purl.org/obo/owl/IMR#IMR_0000473
PubMed:12121659
http://purl.org/obo/owl/PubMed#PubMed_12121659
IMR:0100352
http://purl.org/obo/owl/IMR#IMR_0100352
Binding of CD28 and PI3K in cytosol
event
IMR:0000473
http://purl.org/obo/owl/IMR#IMR_0000473
IMR:0000265
http://purl.org/obo/owl/IMR#IMR_0000265
AKT(PKB) activation signaling
event
PI3K-AKT signaling
PubMed:10485710
http://purl.org/obo/owl/PubMed#PubMed_10485710
PubMed:10485710
http://purl.org/obo/owl/PubMed#PubMed_10485710
Regulation of AKT(PKB) activation signaling
event
Negative regulation of AKT(PKB) activation signaling
event
Positive regulation of AKT(PKB) activation signaling
event
Dephosphorylation of PIP3 by PTEN in plasma membrane
event
IMR:0001352
http://purl.org/obo/owl/IMR#IMR_0001352
IMR:0100701
http://purl.org/obo/owl/IMR#IMR_0100701
Keratan sulfate biosynthesis
event
keratan sulfate synthesis
The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues.
GO:0018146
http://purl.org/obo/owl/GO#GO_0018146
keratan sulphate biosynthetic process
keratan sulphate biosynthesis
keratan sulfate anabolism
KEGG:map00533
http://purl.org/obo/owl/KEGG#KEGG_map00533
keratan sulfate biosynthetic process
GO:0018146
http://purl.org/obo/owl/GO#GO_0018146
keratan sulfate formation
Glycosaminoglycan degradation
event
GO:0006027
http://purl.org/obo/owl/GO#GO_0006027
glycosaminoglycan catabolism
glycosaminoglycan breakdown
glycosaminoglycan catabolic process
KEGG:map00531
http://purl.org/obo/owl/KEGG#KEGG_map00531
The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars.
GO:0006027
http://purl.org/obo/owl/GO#GO_0006027
Lipopolysaccharide biosynthesis
event
The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.
GO:0009103
http://purl.org/obo/owl/GO#GO_0009103
lipopolysaccharide synthesis
lipopolysaccharide formation
lipopolysaccharide biosynthetic process
lipopolysaccharide anabolism
KEGG:map00540
http://purl.org/obo/owl/KEGG#KEGG_map00540
GO:0009103
http://purl.org/obo/owl/GO#GO_0009103
Peptidoglycan biosynthesis
event
peptidoglycan synthesis
peptidoglycan biosynthetic process
peptidoglycan formation
KEGG:map00550
http://purl.org/obo/owl/KEGG#KEGG_map00550
GO:0009252
http://purl.org/obo/owl/GO#GO_0009252
peptidoglycan anabolism
murein biosynthetic process
murein biosynthesis
The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls.
GO:0009252
http://purl.org/obo/owl/GO#GO_0009252
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
event
The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage.
GO:0006506
http://purl.org/obo/owl/GO#GO_0006506
KEGG:map00563
http://purl.org/obo/owl/KEGG#KEGG_map00563
GPI anchor anabolism
GPI anchor biosynthetic process
glycosylphosphatidylinositol biosynthesis
glycosylphosphatidylinositol biosynthetic process
GO:0006506
http://purl.org/obo/owl/GO#GO_0006506
GPI anchor formation
GPI anchor synthesis
Sphingolipid metabolism
event
The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
GO:0006665
http://purl.org/obo/owl/GO#GO_0006665
KEGG:map00600
http://purl.org/obo/owl/KEGG#KEGG_map00600
GO:0006665
http://purl.org/obo/owl/GO#GO_0006665
sphingolipid metabolic process
Glycosphingolipid biosynthesis-lactoseries
event
KEGG:map00601
http://purl.org/obo/owl/KEGG#KEGG_map00601
Glycosphingolipid biosynthesis-neo-lactoseries
event
KEGG:map00601
http://purl.org/obo/owl/KEGG#KEGG_map00601
Glycosphingolipid biosynthesis-globoseries
event
GO:0001575
http://purl.org/obo/owl/GO#GO_0001575
KEGG:map00603
http://purl.org/obo/owl/KEGG#KEGG_map00603
globoside metabolic process
The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1,3)-Gal-alpha(1,4)Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes.
GO:0001575
http://purl.org/obo/owl/GO#GO_0001575
globoside metabolism
Glycosphingolipid biosynthesis-ganglioseries
event
GO:0001574
http://purl.org/obo/owl/GO#GO_0001574
ganglioside anabolism
ganglioside biosynthesis
ganglioside formation
The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.
GO:0001574
http://purl.org/obo/owl/GO#GO_0001574
ganglioside biosynthetic process
ganglioside synthesis
KEGG:map00604
http://purl.org/obo/owl/KEGG#KEGG_map00604
Biosynthesis of vancomycin group antibiotics
event
KEGG:map01055
http://purl.org/obo/owl/KEGG#KEGG_map01055
Biosynthesis of 12-, 14- and 16-membered macrolides
event
KEGG:map00522
http://purl.org/obo/owl/KEGG#KEGG_map00522
Biosynthesis of ansamycins
event
The chemical reactions and pathways leading to the formation of ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity.
GO:0033070
http://purl.org/obo/owl/GO#GO_0033070
ansamycin biosynthetic process
KEGG:map01051
http://purl.org/obo/owl/KEGG#KEGG_map01051
ansamycin biosynthesis
GO:0033070
http://purl.org/obo/owl/GO#GO_0033070
ansamycin anabolism
ansamycin synthesis
ansamycin formation
Biosynthesis of type II polyketide backbone
event
KEGG:map01056
http://purl.org/obo/owl/KEGG#KEGG_map01056
Biosynthesis of type II polyketide products
event
KEGG:map01057
http://purl.org/obo/owl/KEGG#KEGG_map01057
Polyketide sugar unit biosynthesis
event
KEGG:map00523
http://purl.org/obo/owl/KEGG#KEGG_map00523
Receptor internalization
event
GO:0031623
http://purl.org/obo/owl/GO#GO_0031623
The process by which cell surface receptors are monoubiquitinated following ligand-induced activation, and subsequently taken up into endocytic vesicles and targeted to the lysosome or vacuole for degradation; serves as a mechanism to downregulate receptor signaling.
GO:0031623
http://purl.org/obo/owl/GO#GO_0031623
Biosynthesis of siderophore group nonribosomal peptides
event
KEGG:map01053
http://purl.org/obo/owl/KEGG#KEGG_map01053
Thiamine metabolism
event
GO:0006772
http://purl.org/obo/owl/GO#GO_0006772
The chemical reactions and pathways involving thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
GO:0006772
http://purl.org/obo/owl/GO#GO_0006772
vitamin B1 metabolism
vitamin B1 metabolic process
thiamin metabolic process
thiamine metabolic process
thiamin metabolism
KEGG:map00730
http://purl.org/obo/owl/KEGG#KEGG_map00730
Riboflavin metabolism
event
vitamin B2 metabolism
vitamin G metabolic process
riboflavin metabolic process
vitamin B2 metabolic process
vitamin G metabolism
The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
GO:0006771
http://purl.org/obo/owl/GO#GO_0006771
KEGG:map00740
http://purl.org/obo/owl/KEGG#KEGG_map00740
GO:0006771
http://purl.org/obo/owl/GO#GO_0006771
Vitamin B6 metabolism
event
vitamin B6 metabolic process
The chemical reactions and pathways involving any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.
GO:0042816
http://purl.org/obo/owl/GO#GO_0042816
KEGG:map00750
http://purl.org/obo/owl/KEGG#KEGG_map00750
GO:0042816
http://purl.org/obo/owl/GO#GO_0042816
Nicotinate and nicotinamide metabolism
event
KEGG:map00760
http://purl.org/obo/owl/KEGG#KEGG_map00760
Nicotinamide metabolism: The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms.
GO:0006769
http://purl.org/obo/owl/GO#GO_0006769
GO:0046497
http://purl.org/obo/owl/GO#GO_0046497
GO:0006769
http://purl.org/obo/owl/GO#GO_0006769
Pantothenate biosynthesis
event
pantothenate anabolism
KEGG:map00770
http://purl.org/obo/owl/KEGG#KEGG_map00770
GO:0015940
http://purl.org/obo/owl/GO#GO_0015940
pantothenate biosynthetic process
pantothenate formation
pantothenate synthesis
vitamin B5 biosynthesis
vitamin B5 biosynthetic process
The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods.
GO:0015940
http://purl.org/obo/owl/GO#GO_0015940
Biotin metabolism
event
vitamin H metabolism
vitamin H metabolic process
The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions.
GO:0006768
http://purl.org/obo/owl/GO#GO_0006768
biotin metabolic process
GO:0006768
http://purl.org/obo/owl/GO#GO_0006768
KEGG:map00780
http://purl.org/obo/owl/KEGG#KEGG_map00780
vitamin B7 metabolic process
vitamin B7 metabolism
Folate metabolism
IEV:0001513
event
folic acid metabolic process
folate metabolic process
vitamin M metabolism
vitamin B9 metabolism
vitamin M metabolic process
folic acid metabolism
KEGG:map00790
http://purl.org/obo/owl/KEGG#KEGG_map00790
vitamin B9 metabolic process
GO:0046655
http://purl.org/obo/owl/GO#GO_0046655
KEGG:map00670
http://purl.org/obo/owl/KEGG#KEGG_map00670
The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
GO:0046655
http://purl.org/obo/owl/GO#GO_0046655
Retinol metabolism
event
The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.
GO:0042572
http://purl.org/obo/owl/GO#GO_0042572
GO:0042572
http://purl.org/obo/owl/GO#GO_0042572
KEGG:map00830
http://purl.org/obo/owl/KEGG#KEGG_map00830
vitamin A1 alcohol metabolism
vitamin A1 metabolic process
vitamin A1 metabolism
retinol metabolic process
vitamin A1 alcohol metabolic process
Porphyrin and chlorophyll metabolism
event
GO:0015994
http://purl.org/obo/owl/GO#GO_0015994
KEGG:map00860
http://purl.org/obo/owl/KEGG#KEGG_map00860
Porphyrin metabolism: The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.nChlorophyll metabolism: The chemical reactions and pathways involving chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment.
GO:0006778
http://purl.org/obo/owl/GO#GO_0006778
GO:0015994
http://purl.org/obo/owl/GO#GO_0015994
GO:0006778
http://purl.org/obo/owl/GO#GO_0006778
Ubiquinone biosynthesis
event
ubiquinone anabolism
ubiquinone biosynthetic process
coenzyme Q biosynthesis
coenzyme Q biosynthetic process
ubiquinone formation
ubiquinone synthesis
The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
GO:0006744
http://purl.org/obo/owl/GO#GO_0006744
KEGG:map00130
http://purl.org/obo/owl/KEGG#KEGG_map00130
GO:0006744
http://purl.org/obo/owl/GO#GO_0006744
Terpenoid biosynthesis
event
The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure.
GO:0016114
http://purl.org/obo/owl/GO#GO_0016114
KEGG:map00900
http://purl.org/obo/owl/KEGG#KEGG_map00900
terpenoid synthesis
terpenoid formation
terpenoid biosynthetic process
terpenoid anabolism
GO:0016114
http://purl.org/obo/owl/GO#GO_0016114
Monoterpenoid biosynthesis
event
KEGG:map00902
http://purl.org/obo/owl/KEGG#KEGG_map00902
monoterpenoid biosynthetic process
monoterpenoid anabolism
GO:0016099
http://purl.org/obo/owl/GO#GO_0016099
monoterpenoid synthesis
monoterpenoid formation
The chemical reactions and pathways resulting in the formation of monoterpenoid compounds, terpenoids having a C10 skeleton.
GO:0016099
http://purl.org/obo/owl/GO#GO_0016099
Limonene and pinene degradation
event
GO:0046249
http://purl.org/obo/owl/GO#GO_0046249
Limonene degradation: The chemical reactions and pathways resulting in the breakdown of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene. nalpha-pinene degradation: The chemical reactions and pathways resulting in the breakdown of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature.
GO:0046249
http://purl.org/obo/owl/GO#GO_0046249
GO:0046251
http://purl.org/obo/owl/GO#GO_0046251
GO:0046251
http://purl.org/obo/owl/GO#GO_0046251
KEGG:map00903
http://purl.org/obo/owl/KEGG#KEGG_map00903
Diterpenoid biosynthesis
event
diterpenoid formation
diterpenoid anabolism
diterpenoid biosynthetic process
The chemical reactions and pathways resulting in the formation of diterpenoid compounds, terpenoids with four isoprene units.
GO:0016102
http://purl.org/obo/owl/GO#GO_0016102
diterpenoid synthesis
GO:0016102
http://purl.org/obo/owl/GO#GO_0016102
KEGG:map00904
http://purl.org/obo/owl/KEGG#KEGG_map00904
Indole and ipecac alkaloid biosynthesis
event
GO:0042432
http://purl.org/obo/owl/GO#GO_0042432
Indole biosynthesis: The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan).
GO:0042432
http://purl.org/obo/owl/GO#GO_0042432
KEGG:map00901
http://purl.org/obo/owl/KEGG#KEGG_map00901
Stilbene, coumarine and lignin biosynthesis
event
GO:0009811
http://purl.org/obo/owl/GO#GO_0009811
GO:0009809
http://purl.org/obo/owl/GO#GO_0009809
GO:0009805
http://purl.org/obo/owl/GO#GO_0009805
Stilbene biosynthesis: The chemical reactions and pathways resulting in the formation of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA. nCoumarin biosynthesis: The chemical reactions and pathways resulting in the formation of coumarins, a class of compounds derived from the phenylacrylic skeleton of cinnamic acids. Lignin biosynthesis: The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers.
GO:0009811
http://purl.org/obo/owl/GO#GO_0009811
GO:0009805
http://purl.org/obo/owl/GO#GO_0009805
GO:0009809
http://purl.org/obo/owl/GO#GO_0009809
Flavonoid biosynthesis
event
The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton.
GO:0009813
http://purl.org/obo/owl/GO#GO_0009813
flavonoid formation
flavonoid synthesis
flavonoid anabolism
flavonoid biosynthetic process
GO:0009813
http://purl.org/obo/owl/GO#GO_0009813
KEGG:map00941
http://purl.org/obo/owl/KEGG#KEGG_map00941
Alkaloid biosynthesis
event
IEV:0001526
alkaloid anabolism
alkaloid biosynthetic process
KEGG:map01058
http://purl.org/obo/owl/KEGG#KEGG_map01058
KEGG:map00960
http://purl.org/obo/owl/KEGG#KEGG_map00960
The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases).
GO:0009821
http://purl.org/obo/owl/GO#GO_0009821
GO:0009821
http://purl.org/obo/owl/GO#GO_0009821
alkaloid formation
KEGG:map00950
http://purl.org/obo/owl/KEGG#KEGG_map00950
alkaloid synthesis
Penicillins and cephalosporins biosynthesis
event
Penicillin biosynthesis: The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system. Cephalosporin biosynthesis: The formation from simpler components of a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria.
GO:0042318
http://purl.org/obo/owl/GO#GO_0042318
GO:0043646
http://purl.org/obo/owl/GO#GO_0043646
GO:0042318
http://purl.org/obo/owl/GO#GO_0042318
GO:0043646
http://purl.org/obo/owl/GO#GO_0043646
KEGG:map00311
http://purl.org/obo/owl/KEGG#KEGG_map00311
beta-Lactam resistanse
event
KEGG:map00312
http://purl.org/obo/owl/KEGG#KEGG_map00312
Streptomycin biosynthesis
event
KEGG:map00521
http://purl.org/obo/owl/KEGG#KEGG_map00521
GO:0019872
http://purl.org/obo/owl/GO#GO_0019872
The chemical reactions and pathways resulting in the formation of streptomycin, a commonly used antibiotic in cell culture media; it acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome.
GO:0019872
http://purl.org/obo/owl/GO#GO_0019872
streptomycin synthesis
streptomycin biosynthetic process
streptomycin formation
streptomycin anabolism
Tetracycline biosynthesis
event
The formation from simpler components of tetracycline, a broad spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles).
GO:0043644
http://purl.org/obo/owl/GO#GO_0043644
GO:0043644
http://purl.org/obo/owl/GO#GO_0043644
tetracyclin biosynthesis
tetracycline biosynthetic process
KEGG:map00253
http://purl.org/obo/owl/KEGG#KEGG_map00253
Clavulanic acid biosynthesis
event
GO:0033050
http://purl.org/obo/owl/GO#GO_0033050
KEGG:map00331
http://purl.org/obo/owl/KEGG#KEGG_map00331
clavulanic acid formation
clavulanic acid biosynthetic process
clavulanic acid synthesis
clavulanic acid anabolism
The chemical reactions and pathways resulting in the formation of clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.
GO:0033050
http://purl.org/obo/owl/GO#GO_0033050
Puromycin biosynthesis
event
puromycin biosynthetic process
GO:0043638
http://purl.org/obo/owl/GO#GO_0043638
KEGG:map00231
http://purl.org/obo/owl/KEGG#KEGG_map00231
The chemical reactions and pathways resulting in the formation of puromycin, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger.
GO:0043638
http://purl.org/obo/owl/GO#GO_0043638
Novobiocin biosynthesis
event
KEGG:map00401
http://purl.org/obo/owl/KEGG#KEGG_map00401
novobiocin biosynthetic process
The chemical reactions and pathways resulting in the formation of novobiocin, a coumarin antibiotic produced by the bacterium gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase.
GO:0043642
http://purl.org/obo/owl/GO#GO_0043642
GO:0043642
http://purl.org/obo/owl/GO#GO_0043642
Caprolactam degradation
event
KEGG:map00930
http://purl.org/obo/owl/KEGG#KEGG_map00930
caprolactam catabolic process
GO:0019384
http://purl.org/obo/owl/GO#GO_0019384
caprolactam breakdown
The chemical reactions and pathways resulting in the breakdown of caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid.
GO:0019384
http://purl.org/obo/owl/GO#GO_0019384
caprolactam catabolism
Biphenyl degradation
event
biphenyl breakdown
KEGG:map00621
http://purl.org/obo/owl/KEGG#KEGG_map00621
The chemical reactions and pathways resulting in the breakdown of biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs).
GO:0070980
http://purl.org/obo/owl/GO#GO_0070980
biphenyl catabolism
biphenyl catabolic process
GO:0070980
http://purl.org/obo/owl/GO#GO_0070980
Toluene and xylene degradation
event
GO:0042203
http://purl.org/obo/owl/GO#GO_0042203
GO:0042184
http://purl.org/obo/owl/GO#GO_0042184
KEGG:map00622
http://purl.org/obo/owl/KEGG#KEGG_map00622
Toluene degradation: The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products.nXylene degradation: The chemical reactions and pathways resulting in the breakdown of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene.
GO:0042184
http://purl.org/obo/owl/GO#GO_0042184
GO:0042203
http://purl.org/obo/owl/GO#GO_0042203
gamma-Hexachlorocyclohexane degradation
event
GO:0018919
http://purl.org/obo/owl/GO#GO_0018919
KEGG:map00361
http://purl.org/obo/owl/KEGG#KEGG_map00361
3-Chloroacrylic acid degradation
event
KEGG:map00641
http://purl.org/obo/owl/KEGG#KEGG_map00641
GO:0018888
http://purl.org/obo/owl/GO#GO_0018888
1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane degradation
event
GO:0042188
http://purl.org/obo/owl/GO#GO_0042188
KEGG:map00351
http://purl.org/obo/owl/KEGG#KEGG_map00351
DDT catabolic process
DDT catabolism
The chemical reactions and pathways resulting in the breakdown of 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide.
GO:0042188
http://purl.org/obo/owl/GO#GO_0042188
1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolism
1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process
1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane breakdown
2,4-Dichlorobenzoate degradation
event
GO:0046298
http://purl.org/obo/owl/GO#GO_0046298
The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs).
GO:0046298
http://purl.org/obo/owl/GO#GO_0046298
2,4-dichlorobenzoate breakdown
2,4-dichlorobenzoate catabolism
2,4-dichlorobenzoate catabolic process
KEGG:map00623
http://purl.org/obo/owl/KEGG#KEGG_map00623
1,2-Dichloroethane degradation
event
1,2-dichloroethane breakdown
1,2-dichloroethane catabolic process
KEGG:map00631
http://purl.org/obo/owl/KEGG#KEGG_map00631
GO:0019260
http://purl.org/obo/owl/GO#GO_0019260
The chemical reactions and pathways resulting in the breakdown of 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride.
GO:0019260
http://purl.org/obo/owl/GO#GO_0019260
1,2-dichloroethane catabolism
Tetrachloroethene degradation
event
tetrachloroethene catabolic process
The chemical reactions and pathways resulting in the breakdown of tetrachloroethylene, a derivative of ethene with the hydrogen atoms replaced by chlorines.
GO:0019337
http://purl.org/obo/owl/GO#GO_0019337
tetrachloroethylene catabolic process
tetrachloroethylene catabolism
tetrachloroethene catabolism
tetrachloroethylene breakdown
tetrachloroethylene degradation
KEGG:map00625
http://purl.org/obo/owl/KEGG#KEGG_map00625
GO:0019337
http://purl.org/obo/owl/GO#GO_0019337
Styrene degradation
event
The chemical reactions and pathways resulting in the breakdown of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene.
GO:0042207
http://purl.org/obo/owl/GO#GO_0042207
KEGG:map00643
http://purl.org/obo/owl/KEGG#KEGG_map00643
styrene breakdown
styrene catabolism
styrene catabolic process
GO:0042207
http://purl.org/obo/owl/GO#GO_0042207
1,4-Dichlorobenzene degradation
event
KEGG:map00627
http://purl.org/obo/owl/KEGG#KEGG_map00627
1,4-dichlorobenzene breakdown
GO:0019261
http://purl.org/obo/owl/GO#GO_0019261
The chemical reactions and pathways resulting in the breakdown of 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring.
GO:0019261
http://purl.org/obo/owl/GO#GO_0019261
1,4-dichlorobenzene catabolism
1,4-dichlorobenzene catabolic process
Nitrobenzene degradation
event
KEGG:map00626
http://purl.org/obo/owl/KEGG#KEGG_map00626
GO:0018916
http://purl.org/obo/owl/GO#GO_0018916
Ethylbenzene degradation
event
GO:0010130
http://purl.org/obo/owl/GO#GO_0010130
KEGG:map00642
http://purl.org/obo/owl/KEGG#KEGG_map00642
The chemical reactions and pathways resulting in the breakdown of ethylbenzene, a benzene derivative with an ethyl group attached to the ring, which occurs in the absence of oxygen.
GO:0010130
http://purl.org/obo/owl/GO#GO_0010130
Fluorene degradation
event
The chemical reactions and pathways resulting in the breakdown of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents.
GO:0019429
http://purl.org/obo/owl/GO#GO_0019429
fluorene catabolic process
fluorene breakdown
fluorene catabolism
GO:0019429
http://purl.org/obo/owl/GO#GO_0019429
KEGG:map00628
http://purl.org/obo/owl/KEGG#KEGG_map00628
Carbazole degradation
event
carbazole catabolic process
carbazole breakdown
GO:0046232
http://purl.org/obo/owl/GO#GO_0046232
The chemical reactions and pathways resulting in the breakdown of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen.
GO:0046232
http://purl.org/obo/owl/GO#GO_0046232
KEGG:map00629
http://purl.org/obo/owl/KEGG#KEGG_map00629
carbazole catabolism
Benzoate degradation via CoA ligation
event
The chemical reactions and pathways resulting in the breakdown of benzoate, by its ligation to Coenzyme A to form benzoyl-CoA, which is then broken by an aerobic or anaerobic pathway.
GO:0010128
http://purl.org/obo/owl/GO#GO_0010128
KEGG:map00632
http://purl.org/obo/owl/KEGG#KEGG_map00632
benzoate catabolic process via CoA ligation
anaerobic benzoate degradation
anaerobic benzoate breakdown
anaerobic benzoate catabolism
anaerobic benzoate catabolic process
GO:0010128
http://purl.org/obo/owl/GO#GO_0010128
Benzoate degradation via hydroxylation
event
KEGG:map00362
http://purl.org/obo/owl/KEGG#KEGG_map00362
GO:0043640
http://purl.org/obo/owl/GO#GO_0043640
benzoate breakdown via hydroxylation
benzoate catabolic process via hydroxylation
The chemical reactions and pathways resulting in the breakdown of benzoate, by its hydroxylation to cis-1,2-dihydroxybenzoate followed by dehydrogenation to catechol.
GO:0043640
http://purl.org/obo/owl/GO#GO_0043640
Atrazine degradation
event
The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide.
GO:0019381
http://purl.org/obo/owl/GO#GO_0019381
KEGG:map00791
http://purl.org/obo/owl/KEGG#KEGG_map00791
atrazine breakdown
GO:0019381
http://purl.org/obo/owl/GO#GO_0019381
atrazine catabolism
atrazine catabolic process
Energy Metabolism
event
Lipid Metabolism
event
GO:0006629
http://purl.org/obo/owl/GO#GO_0006629
KEGG:map01130
http://purl.org/obo/owl/KEGG#KEGG_map01130
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
GO:0006629
http://purl.org/obo/owl/GO#GO_0006629
lipid metabolic process
Nucleotide Metabolism
event
nucleotide metabolic process
GO:0009117
http://purl.org/obo/owl/GO#GO_0009117
The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).
GO:0009117
http://purl.org/obo/owl/GO#GO_0009117
Metabolism of Cofactors and Vitamins
event
GO:0006766
http://purl.org/obo/owl/GO#GO_0006766
GO:0051186
http://purl.org/obo/owl/GO#GO_0051186
Cofactor metabolism: The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.nVitamin metabolism: The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.
GO:0006766
http://purl.org/obo/owl/GO#GO_0006766
GO:0051186
http://purl.org/obo/owl/GO#GO_0051186
Amino Acid Metabolism
event
GO:0006520
http://purl.org/obo/owl/GO#GO_0006520
amino acid metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.
GO:0006520
http://purl.org/obo/owl/GO#GO_0006520
Amino acid derivative metabolism
event
GO:0006575
http://purl.org/obo/owl/GO#GO_0006575
The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.
GO:0006575
http://purl.org/obo/owl/GO#GO_0006575
Glycan Biosynthesis and Metabolism
event
GO:0005976
http://purl.org/obo/owl/GO#GO_0005976
GO:0000271
http://purl.org/obo/owl/GO#GO_0000271
Glycan biosynthesis: The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages.nGlycan metabolism: The chemical reactions and pathways involving polysaccharides, a polymer of more than 10 monosaccharide residues joined by glycosidic linkages.
GO:0000271
http://purl.org/obo/owl/GO#GO_0000271
GO:0005976
http://purl.org/obo/owl/GO#GO_0005976
Polyketide biosynthesis
event
GO:0030639
http://purl.org/obo/owl/GO#GO_0030639
polyketide synthesis
polyketide formation
polyketide biosynthetic process
polyketide anabolism
The chemical reactions and pathways resulting in the formation of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty-acid biosynthesis but without the intermediate reductive steps.
GO:0030639
http://purl.org/obo/owl/GO#GO_0030639
Biosynthesis of Secondary Metabolites
event
Xenobiotics Biodegradation and Metabolism
event
GO:0006805
http://purl.org/obo/owl/GO#GO_0006805
Xenobiotic degradation: The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide. nXenobiotic metabolism: The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
GO:0006805
http://purl.org/obo/owl/GO#GO_0006805
GO:0042178
http://purl.org/obo/owl/GO#GO_0042178
GO:0042178
http://purl.org/obo/owl/GO#GO_0042178
Osmotic pressure treatment
event
Humidity treatment
event
High osmotic pressure treatment
event
Heat shock treatment
event
Anticancer drug medication
event
Protein synthesis inhibitor medication
event
Ultraviolet irradiation
event
Cyclohexemide medication
event
Proteasome inhibitor medication
event
Transcription inhibitor medication
event
DRB medication
event
Hydrogen peroxide treatment
event
Abscisic acid stimulus
event
Auxin stimulus
event
Sorbitol treatment
event
Brassinosteroid stimulus
event
Cytokinin stimulus
event
Ethylene stimulus
event
Gibberellic acid stimulus
event
Carbohydrate treatment
event
Hexose treatment
event
Sucrose treatment
event
Fructose treatment
event
Glucose treatment
event
Anisomycin medication
event
Puromycin medication
event
Actinomycin medication
event
Src family activation signaling
event
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
Src family inactivation signaling
event
PubMed:11781344
http://purl.org/obo/owl/PubMed#PubMed_11781344
Phosphorylation of Lck by non-receptor kinase and inactive conformational change in cytosol
event
IMR:0000682
http://purl.org/obo/owl/IMR#IMR_0000682
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
IMR:0100353
http://purl.org/obo/owl/IMR#IMR_0100353
Dephosphorylation of Lck_p by PTP in cytosol
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Dephosphorylation of Lck_p (autophosphorylated) by PTP in cytosol
IMR:0100353
http://purl.org/obo/owl/IMR#IMR_0100353
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
Interaction in the inner space of the nuclear
event
OBSOLETE: remap to 'Unknown interaction' IEV:0000922.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Dephosphorylation of Fyn_p by PTP in cytosol
event
Dephosphorylation of Fyn_p (autophosphorylated) by PTP in cytosol
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
IMR:0100352
http://purl.org/obo/owl/IMR#IMR_0100352
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
Protein involved in DNA fragmentation and chromatin condensation signaling
event
Phosphorylation of Fyn by non-receptor kinase and inactive conformational change in cytosol
event
IMR:0000682
http://purl.org/obo/owl/IMR#IMR_0000682
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
IMR:0100352
http://purl.org/obo/owl/IMR#IMR_0100352
Phosphorylation of Src family by Csk and inactive conformational change in cytosol
event
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
IMR:0000211
http://purl.org/obo/owl/IMR#IMR_0000211
Dephosphorylation of Fyn_p by PTP and active conformational change in cytosol
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
IMR:0100352
http://purl.org/obo/owl/IMR#IMR_0100352
Dephosphorylation of Fyn_p (phosphorylated in the C-terminal site) by PTP and active conformational change in cytosol
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
Dephosphorylation of Lck_p by PTP and active conformational change in cytosol
event
IMR:0100353
http://purl.org/obo/owl/IMR#IMR_0100353
Dephosphorylation of Lck_p (phosphorylated in the C-terminal phosphorylation site) by PTP and active conformational change in cytosol
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Dephosphorylation of Src_p by SHP-1 and active conformational change
event
IMR:0000275
http://purl.org/obo/owl/IMR#IMR_0000275
Dephosphorylation of Src (phosphorylated in the C-terminal site) by SHP-1 and active conformational change
IMR:0100575
http://purl.org/obo/owl/IMR#IMR_0100575
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
PubMed:9261115
http://purl.org/obo/owl/PubMed#PubMed_9261115
Dephosphorylation of Src_p by SHP-2 and active conformational change
event
Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP1D and active conformational change
PubMed:7478513
http://purl.org/obo/owl/PubMed#PubMed_7478513
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
IMR:0100575
http://purl.org/obo/owl/IMR#IMR_0100575
IMR:0000276
http://purl.org/obo/owl/IMR#IMR_0000276
EndoG mediated signaling
event
CAD signaling
event
Gene expression of apoptotic factor by p53
event
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
Nuclear import of EndoG
event
UniProt:Q14249
http://purl.org/obo/owl/UniProt#UniProt_Q14249
Src family activation signaling (through autophosphorylation and PTP)
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Autophosphorylation of Src family and active conformational change in cytosol
event
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
IMR:0000211
http://purl.org/obo/owl/IMR#IMR_0000211
Dephosphorylation of Src family_p by PTP and active conformational change in cytosol
event
IMR:0000211
http://purl.org/obo/owl/IMR#IMR_0000211
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Dephosphorylation of Src family (phosphorylated in the C-terminal site) by PTP and active conformational change in cytosol
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
Fyn activation signaling
event
Lck activation signaling
event
Dephosphorylation of Src family_p by PTP in cytosol
event
Dephosphorylation of Src family (autophosphorylated) by PTP in cytosol
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
IMR:0000211
http://purl.org/obo/owl/IMR#IMR_0000211
Phosphorylation of Src family by non-receptor kinase and inactive conformational change in cytosol
event
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
IMR:0000682
http://purl.org/obo/owl/IMR#IMR_0000682
IMR:0000211
http://purl.org/obo/owl/IMR#IMR_0000211
Regulation of Fyn activation signaling
event
Negative regulation of Fyn activation signaling
event
Positive regulation of Fyn activation signaling
event
Regulation of Lck activation signaling
event
Negative regulation of Lck activation signaling
event
Positive regulation of Lck activation signaling
event
Regulation of Src activation signaling
event
Negative regulation of Src activation signaling
event
Positive regulation of Src activation signaling
event
Regulation of Src family activation signaling (autophosphorylation and PTP)
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Negative regulation of Src family activation signaling (autophosphorylation and PTP)
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Positive regulation of Src family activation signaling (autophosphorylation and PTP)
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Regulation of src activation signaling (through Estrogen receptor)
event
Negative regulation of src activation signaling (through Estrogen receptor)
event
Positive regulation of src activation signaling (through Estrogen receptor)
event
Regulation of Fyn activation signaling (through autophosphorylation and PTP)
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Negative regulation of Fyn activation signaling (through autophosphorylation and PTP)
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Positive regulation of Fyn activation signaling (autophosphorylation and PTP)
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Regulation of Lck activation signaling (autophosphorylation and PTP)
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Negative regulation of (dephosphorylation of Lck) Lck activation signaling (autophosphorylation and PTP)
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Positive regulation of Lck activation signaling (autophosphorylation and PTP)
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Fyn inactivation signaling
event
Lck inactivation signaling
event
Src activation signaling (through autophosphorylation and PTP)
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Autophosphorylation of Src and active conformational change in cytosol
event
p416
PubMed:11804588
http://purl.org/obo/owl/PubMed#PubMed_11804588
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
PubMed:11804588
http://purl.org/obo/owl/PubMed#PubMed_11804588
IMR:0100575
http://purl.org/obo/owl/IMR#IMR_0100575
Dephosphorylation of Src_p by PTP and active conformational change in cytosol
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP and active conformational change in cytosol
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
IMR:0100575
http://purl.org/obo/owl/IMR#IMR_0100575
Regulation of Src activation signaling (through autophosphorylation and PTP)
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Negative regulation of Src activation signaling (through autophosphorylation and PTP)
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Positive regulation of Src activation signaling (through autophosphorylation and PTP)
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Src inactivation signaling
event
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
Dephosphorylation of Src_p by PTP in cytosol
event
Dephosphorylation of Src (autophosphorylated) by PTP in cytosol
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
IMR:0100575
http://purl.org/obo/owl/IMR#IMR_0100575
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
Phosphorylation of Src by non-receptor kinase and inactive conformational change in cytosol
event
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
IMR:0100575
http://purl.org/obo/owl/IMR#IMR_0100575
IMR:0000682
http://purl.org/obo/owl/IMR#IMR_0000682
Phosphorylation of Src by Csk and inactive conformational change in cytosol
event
IMR:0000212
http://purl.org/obo/owl/IMR#IMR_0000212
PubMed:12480346
http://purl.org/obo/owl/PubMed#PubMed_12480346
IMR:0100575
http://purl.org/obo/owl/IMR#IMR_0100575
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
Dephosphorylation of Src_p by PTP alpha and active conformational change
event
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
UniProt:P18433
http://purl.org/obo/owl/UniProt#UniProt_P18433
Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP alpha and active conformational change
IMR:0100575
http://purl.org/obo/owl/IMR#IMR_0100575
Dephosphorylation of Src_p by PTP lambda and active conformational change
event
IMR:0100575
http://purl.org/obo/owl/IMR#IMR_0100575
UniProt:Q92729
http://purl.org/obo/owl/UniProt#UniProt_Q92729
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP lambda and active conformational change
Dephosphorylation of Src_p by PTP1B and active conformational change
event
PubMed:15034556
http://purl.org/obo/owl/PubMed#PubMed_15034556
IMR:0100575
http://purl.org/obo/owl/IMR#IMR_0100575
Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP1B and active conformational change
UniProt:P18031
http://purl.org/obo/owl/UniProt#UniProt_P18031
Permeabilization of mitochondria and Translocation of EndoG from mitochondria to cytosol
event
UniProt:Q14249
http://purl.org/obo/owl/UniProt#UniProt_Q14249
Gene expression of BAK by p53
event
IMR:0000452
http://purl.org/obo/owl/IMR#IMR_0000452
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
Gene expression of Bid by p53
event
IMR:0100289
http://purl.org/obo/owl/IMR#IMR_0100289
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
Gene expression of NOXA by p53
event
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
IMR:0001210
http://purl.org/obo/owl/IMR#IMR_0001210
Gene expression of PUMA by p53
event
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
IMR:0001211
http://purl.org/obo/owl/IMR#IMR_0001211
Nuclear export of mRNA (BAK)
event
IMR:0000452
http://purl.org/obo/owl/IMR#IMR_0000452
Nuclear export of mRNA (Bid)
event
IMR:0100289
http://purl.org/obo/owl/IMR#IMR_0100289
Nuclear export of mRNA (NOXA)
event
IMR:0001210
http://purl.org/obo/owl/IMR#IMR_0001210
Nuclear export of mRNA (PUMA)
event
IMR:0001211
http://purl.org/obo/owl/IMR#IMR_0001211
Transcription of BAK by p53 in nucleus
event
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
IMR:0000452
http://purl.org/obo/owl/IMR#IMR_0000452
Transcription of Bid by p53 in nucleus
event
IMR:0100289
http://purl.org/obo/owl/IMR#IMR_0100289
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
Translation of NOXA in cytosol
event
IMR:0001210
http://purl.org/obo/owl/IMR#IMR_0001210
Transcription of apoptotic factor by p53 in nucleus
event
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
Translation of apoptotic factor in cytosol
event
Translation of BAK in cytosol
event
IMR:0000452
http://purl.org/obo/owl/IMR#IMR_0000452
Translation of Bid in cytosol
event
IMR:0100289
http://purl.org/obo/owl/IMR#IMR_0100289
Translation of PUMA in cytosol
event
IMR:0001211
http://purl.org/obo/owl/IMR#IMR_0001211
Permeabilization of mitochondria and Translocation of OMI from mitochondria to cytosol
event
UniProt:O43464
http://purl.org/obo/owl/UniProt#UniProt_O43464
Bcl-2/Bcl-xL inactivation signaling
event
Relocation of free Bid to cytosol
event
IMR:0100289
http://purl.org/obo/owl/IMR#IMR_0100289
Positive signal transduction regulation pathway
event
GO:0035468
http://purl.org/obo/owl/GO#GO_0035468
Any process that activates or increases the frequency, rate or extent of a signaling pathway.
GO:0035468
http://purl.org/obo/owl/GO#GO_0035468
Negative signal transduction regulation pathway
event
Any process that stops, prevents or reduces the frequency, rate or extent of a signaling pathway.
GO:0035467
http://purl.org/obo/owl/GO#GO_0035467
GO:0035467
http://purl.org/obo/owl/GO#GO_0035467
Negative regulation of PDGF receptor signaling pathway
event
Positive regulation of PDGF signaling pathway
event
Negative regulation of Toll-like receptor pathway
event
negative regulation of TLR signaling pathway
GO:0034122
http://purl.org/obo/owl/GO#GO_0034122
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway.
GO:0034122
http://purl.org/obo/owl/GO#GO_0034122
Positive regulation of Toll-like receptor pathway
event
positive regulation of TLR signaling pathway
GO:0034123
http://purl.org/obo/owl/GO#GO_0034123
Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway.
GO:0034123
http://purl.org/obo/owl/GO#GO_0034123
Regulation of Wnt signaling pathway
event
Any process that modulates the frequency, rate or extent of the activity of the Wnt receptor mediated signal transduction pathway.
GO:0030111
http://purl.org/obo/owl/GO#GO_0030111
GO:0030111
http://purl.org/obo/owl/GO#GO_0030111
Negative regulation of Wnt signaling pathway
event
Any process that stops, prevents or reduces the rate, frequency or extent of Wnt receptor signaling pathway activity.
GO:0030178
http://purl.org/obo/owl/GO#GO_0030178
GO:0030178
http://purl.org/obo/owl/GO#GO_0030178
Positive regulation of Wnt signaling pathway
event
Any process that activates or increases the rate, frequency or extent of Wnt receptor signaling pathway activity.
GO:0030177
http://purl.org/obo/owl/GO#GO_0030177
GO:0030177
http://purl.org/obo/owl/GO#GO_0030177
Caloric restriction
event
PubMed:15205477
http://purl.org/obo/owl/PubMed#PubMed_15205477
Caloric treatment
event
Deacetylation of Ku70 by SIRT1 in nucleus
event
UniProt:Q96EB6
http://purl.org/obo/owl/UniProt#UniProt_Q96EB6
PubMed:15205477
http://purl.org/obo/owl/PubMed#PubMed_15205477
EC:3.5.1.-
http://purl.org/obo/owl/EC#EC_3.5.1.-
IMR:0010335
http://purl.org/obo/owl/IMR#IMR_0010335
Deacetylation
event
N6-acetyl-L-lysine or S-acetyl-L-cysteine are cleaved and return K or C residues.
MI:0197
http://purl.org/obo/owl/MI#MI_0197
MI:0197
http://purl.org/obo/owl/MI#MI_0197
Deacetylation in cytosol
event
Deacetylation in nucleus
event
Deacetylation in unidentified cellular location
event
Regulation of caloric restriction - cell survival signaling
event
Caloric restriction - cell survival signaling
event
Regulation of IGF signaling pathway
event
regulation of insulin-like growth factor receptor signaling pathwa
GO:0043567
http://purl.org/obo/owl/GO#GO_0043567
regulation of IGF receptor signaling pathway
GO:0043567
http://purl.org/obo/owl/GO#GO_0043567
GO:0043567
http://purl.org/obo/owl/GO#GO_0043567
Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling.
GO:0043567
http://purl.org/obo/owl/GO#GO_0043567
Negative regulation of IGF receptor signaling pathway
event
negative regulation of insulin-like growth factor receptor signaling pathway
GO:0043569
http://purl.org/obo/owl/GO#GO_0043569
Any process that stops, prevents or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling.
GO:0043569
http://purl.org/obo/owl/GO#GO_0043569
GO:0043569
http://purl.org/obo/owl/GO#GO_0043569
Positive regulation of IGF signaling pathway
event
positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043568
http://purl.org/obo/owl/GO#GO_0043568
positive regulation of IGF receptor signaling pathway
GO:0043568
http://purl.org/obo/owl/GO#GO_0043568
GO:0043568
http://purl.org/obo/owl/GO#GO_0043568
Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling.
GO:0043568
http://purl.org/obo/owl/GO#GO_0043568
Negative regulation of caloric restriction - cell survival signaling
event
Positive regulation of caloric restriction - cell survival signaling
event
Translocation of Bax from mitochondria membrane to cytosol
event
PubMed:15205477
http://purl.org/obo/owl/PubMed#PubMed_15205477
IMR:0000453
http://purl.org/obo/owl/IMR#IMR_0000453
Endothelin receptor signaling
event
PubMed:11585834
http://purl.org/obo/owl/PubMed#PubMed_11585834
Binding of endothelin and endothelin receptor in extracellular
event
UniProt:P24530
http://purl.org/obo/owl/UniProt#UniProt_P24530
IMR:0100166
http://purl.org/obo/owl/IMR#IMR_0100166
UniProt:P25101
http://purl.org/obo/owl/UniProt#UniProt_P25101
Regulation of endothelin receptor signaling
event
Regulation of endothelin receptor signaling pathway
Negative regulation of endothelin receptor signaling
event
Negative regulation of endothelin receptor signaling pathway
Positive regulation of endothelin receptor signaling
event
Positive regulation of endothelin receptor signaling pathway
Binding of 14-3-3 and HDAC5/7 in cytosol and/or nucleus
event
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
PubMed:11585834
http://purl.org/obo/owl/PubMed#PubMed_11585834
PubMed:15166223
http://purl.org/obo/owl/PubMed#PubMed_15166223
IMR:0001171
http://purl.org/obo/owl/IMR#IMR_0001171
IMR:0001173
http://purl.org/obo/owl/IMR#IMR_0001173
IMR:0000456
http://purl.org/obo/owl/IMR#IMR_0000456
AKT signaling
event
GO:0043491
http://purl.org/obo/owl/GO#GO_0043491
AKT signaling cascade
GO:0043491
http://purl.org/obo/owl/GO#GO_0043491
protein kinase B signaling cascade
GO:0043491
http://purl.org/obo/owl/GO#GO_0043491
PKB signaling cascade
GO:0043491
http://purl.org/obo/owl/GO#GO_0043491
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B, which occurs as a result of a single trigger reaction or compound.
GO:0043491
http://purl.org/obo/owl/GO#GO_0043491
Phosphorylation of HDAC5/7 by CaMK in cytosol and/or nucleus
event
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
PubMed:11585834
http://purl.org/obo/owl/PubMed#PubMed_11585834
PubMed:15166223
http://purl.org/obo/owl/PubMed#PubMed_15166223
IMR:0001171
http://purl.org/obo/owl/IMR#IMR_0001171
IMR:0001173
http://purl.org/obo/owl/IMR#IMR_0001173
IMR:0100543
http://purl.org/obo/owl/IMR#IMR_0100543
Dephosphorylation of HDAC5/7 by protein phosphatase in cytosol
event
IMR:0000272
http://purl.org/obo/owl/IMR#IMR_0000272
IMR:0001171
http://purl.org/obo/owl/IMR#IMR_0001171
IMR:0001173
http://purl.org/obo/owl/IMR#IMR_0001173
Nuclear export of 14-3-3:HDAC5/7:Crm1
event
IMR:0001090
http://purl.org/obo/owl/IMR#IMR_0001090
IMR:0001171
http://purl.org/obo/owl/IMR#IMR_0001171
IMR:0001173
http://purl.org/obo/owl/IMR#IMR_0001173
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
IMR:0000456
http://purl.org/obo/owl/IMR#IMR_0000456
PubMed:11585834
http://purl.org/obo/owl/PubMed#PubMed_11585834
Binding of HDAC5/7 and MEF2 in inner space of nucleus
event
PubMed:11585834
http://purl.org/obo/owl/PubMed#PubMed_11585834
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
IMR:0001173
http://purl.org/obo/owl/IMR#IMR_0001173
IMR:0001171
http://purl.org/obo/owl/IMR#IMR_0001171
UniProt:Q02078
http://purl.org/obo/owl/UniProt#UniProt_Q02078
Dissociation of 14-3-3 and HDAC5/7 in cytosol
event
IMR:0000456
http://purl.org/obo/owl/IMR#IMR_0000456
IMR:0001171
http://purl.org/obo/owl/IMR#IMR_0001171
IMR:0001173
http://purl.org/obo/owl/IMR#IMR_0001173
Nuclear import of HDAC5/7
event
PubMed:11585834
http://purl.org/obo/owl/PubMed#PubMed_11585834
IMR:0001173
http://purl.org/obo/owl/IMR#IMR_0001173
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
IMR:0001171
http://purl.org/obo/owl/IMR#IMR_0001171
Complex formation of 14-3-3:HDAC5/7:Crm1 in inner space of nucleus
event
PubMed:11585834
http://purl.org/obo/owl/PubMed#PubMed_11585834
IMR:0000456
http://purl.org/obo/owl/IMR#IMR_0000456
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
IMR:0001173
http://purl.org/obo/owl/IMR#IMR_0001173
IMR:0001171
http://purl.org/obo/owl/IMR#IMR_0001171
IMR:0001090
http://purl.org/obo/owl/IMR#IMR_0001090
AKT(PKB)-caspase signaling
event
AKT(PKB)-FOXO signaling
event
AKT(PKB)-FKHR signaling
AKT(PKB)-FKHRL1 signaling
Phosphorylation of FOXO3 by AKT in inner space of nucleus
event
IMR:0000250
http://purl.org/obo/owl/IMR#IMR_0000250
IMR:0002806
http://purl.org/obo/owl/IMR#IMR_0002806
Phosphorylation of FKHRL1 by AKT in inner space of nucleus
Binding of transcription factor and Crm1 in inner space of nucleus
event
IMR:0001090
http://purl.org/obo/owl/IMR#IMR_0001090
IMR:0000368
http://purl.org/obo/owl/IMR#IMR_0000368
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
Binding of Stat1 and Crm1 in inner space of nucleus
event
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
IMR:0001090
http://purl.org/obo/owl/IMR#IMR_0001090
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
Binding of NFAT and Crm1 in inner space of nucleus
event
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
IMR:0001090
http://purl.org/obo/owl/IMR#IMR_0001090
IMR:0000421
http://purl.org/obo/owl/IMR#IMR_0000421
Complex formation of 14-3-3:HDAC5:Crm1 in inner space of nucleus
event
IMR:0001171
http://purl.org/obo/owl/IMR#IMR_0001171
IMR:0001090
http://purl.org/obo/owl/IMR#IMR_0001090
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
IMR:0000456
http://purl.org/obo/owl/IMR#IMR_0000456
Complex formation of 14-3-3:HDAC7:Crm1 in inner space of nucleus
event
IMR:0001173
http://purl.org/obo/owl/IMR#IMR_0001173
PubMed:11585834
http://purl.org/obo/owl/PubMed#PubMed_11585834
IMR:0000456
http://purl.org/obo/owl/IMR#IMR_0000456
IMR:0001090
http://purl.org/obo/owl/IMR#IMR_0001090
Nuclear export of 14-3-3:HDAC5:Crm1
event
IMR:0001090
http://purl.org/obo/owl/IMR#IMR_0001090
IMR:0000456
http://purl.org/obo/owl/IMR#IMR_0000456
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
IMR:0001171
http://purl.org/obo/owl/IMR#IMR_0001171
Nuclear export of 14-3-3:HDAC7:Crm1
event
PubMed:11585834
http://purl.org/obo/owl/PubMed#PubMed_11585834
IMR:0001173
http://purl.org/obo/owl/IMR#IMR_0001173
IMR:0001090
http://purl.org/obo/owl/IMR#IMR_0001090
IMR:0000456
http://purl.org/obo/owl/IMR#IMR_0000456
Binding of HDAC5 and MEF2 in inner space of nucleus
event
IMR:0001171
http://purl.org/obo/owl/IMR#IMR_0001171
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
UniProt:Q02078
http://purl.org/obo/owl/UniProt#UniProt_Q02078
Nuclear import of HDAC5:importin alpha
event
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
Binding of HDAC7 and MEF2 in inner space of nucleus
event
PubMed:11585834
http://purl.org/obo/owl/PubMed#PubMed_11585834
IMR:0001173
http://purl.org/obo/owl/IMR#IMR_0001173
UniProt:Q02078
http://purl.org/obo/owl/UniProt#UniProt_Q02078
Dissociation of 14-3-3 and HDAC5 in cytosol
event
IMR:0000456
http://purl.org/obo/owl/IMR#IMR_0000456
IMR:0001171
http://purl.org/obo/owl/IMR#IMR_0001171
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
Dissociation of 14-3-3 and HDAC7 in cytosol
event
IMR:0000456
http://purl.org/obo/owl/IMR#IMR_0000456
IMR:0001173
http://purl.org/obo/owl/IMR#IMR_0001173
PubMed:11585834
http://purl.org/obo/owl/PubMed#PubMed_11585834
Dephosphorylation of HDAC7 by protein phosphatase in cytosol
event
PubMed:15166223
http://purl.org/obo/owl/PubMed#PubMed_15166223
IMR:0000272
http://purl.org/obo/owl/IMR#IMR_0000272
IMR:0001173
http://purl.org/obo/owl/IMR#IMR_0001173
PubMed:11585834
http://purl.org/obo/owl/PubMed#PubMed_11585834
Dephosphorylation of HDAC5 by protein phosphatase in cytosol
event
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
IMR:0001171
http://purl.org/obo/owl/IMR#IMR_0001171
IMR:0000272
http://purl.org/obo/owl/IMR#IMR_0000272
Binding of TRAF2 and MAPKKK in cytosol
event
IMR:0100423
http://purl.org/obo/owl/IMR#IMR_0100423
IMR:0000229
http://purl.org/obo/owl/IMR#IMR_0000229
PubMed:10485710
http://purl.org/obo/owl/PubMed#PubMed_10485710
Binding of TRAF2 and NIK in cytosol
event
PubMed:10485710
http://purl.org/obo/owl/PubMed#PubMed_10485710
IMR:0100423
http://purl.org/obo/owl/IMR#IMR_0100423
IMR:0000242
http://purl.org/obo/owl/IMR#IMR_0000242
AKT(PKB)-IKK signaling
event
Phosphorylation of IKK alpha by AKT(PKB)
event
IMR:0000250
http://purl.org/obo/owl/IMR#IMR_0000250
Dephosphorylation in cytosol and/or nucleus
event
Binding in cytosol and/or nucleus
event
Binding of 14-3-3 and HDAC5 in inner space of nucleus
event
IMR:0001171
http://purl.org/obo/owl/IMR#IMR_0001171
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
PubMed:15923258
http://purl.org/obo/owl/PubMed#PubMed_15923258
CaMK-mediated nuclear export of HDAC5 appears to require binding of 14-3-3 to Ser-259 and Ser-498 in its amino terminus. Indeed, substitution of these serines with alanines blocks both 14-3-3 binding and nuclear export of HDAC5. However, association with 14-3-3 alone is not sufficient to localize HDAC5 in the cytoplasm, since NES mutants of HDAC5 associate with 14-3-3 in a CaMK-dependent manner but remain in the nucleus.
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
IMR:0000456
http://purl.org/obo/owl/IMR#IMR_0000456
Binding of 14-3-3 and HDAC7 in cytosol and/or nucleus
event
PubMed:15166223
http://purl.org/obo/owl/PubMed#PubMed_15166223
PubMed:11585834
http://purl.org/obo/owl/PubMed#PubMed_11585834
IMR:0001173
http://purl.org/obo/owl/IMR#IMR_0001173
IMR:0000456
http://purl.org/obo/owl/IMR#IMR_0000456
Phosphorylation of HDAC5 by CaMK in inner space of nucleus
event
IMR:0001171
http://purl.org/obo/owl/IMR#IMR_0001171
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
IMR:0100543
http://purl.org/obo/owl/IMR#IMR_0100543
Phosphorylation of HDAC7 by CaMKI in cytosol
event
IMR:0001173
http://purl.org/obo/owl/IMR#IMR_0001173
IMR:0100543
http://purl.org/obo/owl/IMR#IMR_0100543
PubMed:15166223
http://purl.org/obo/owl/PubMed#PubMed_15166223
PubMed:11585834
http://purl.org/obo/owl/PubMed#PubMed_11585834
Phosphorylation in cytosol and/or nucleus
event
Binding of AKT and GSK3beta in cytosol
event
IMR:0100737
http://purl.org/obo/owl/IMR#IMR_0100737
IMR:0000250
http://purl.org/obo/owl/IMR#IMR_0000250
PubMed:11278246
http://purl.org/obo/owl/PubMed#PubMed_11278246
Gene expression of beta-TrCP
event
IMR:0100471
http://purl.org/obo/owl/IMR#IMR_0100471
Binding of APC and beta catenin in cytosol
event
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
PubMed:8259519
http://purl.org/obo/owl/PubMed#PubMed_8259519
IMR:0000205
http://purl.org/obo/owl/IMR#IMR_0000205
Beta catenin degradation signaling
event
GO:0031146
http://purl.org/obo/owl/GO#GO_0031146
SCF-dependent proteasomal ubiquitin-dependent protein degradation
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
GO:0031146
http://purl.org/obo/owl/GO#GO_0031146
Proteasome degradation of beta catenin by 26S proteasome in cytosol
event
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
IMR:0000310
http://purl.org/obo/owl/IMR#IMR_0000310
Phosphorylation of beta-catenin by GSK3beta in cytosol
event
IMR:0100737
http://purl.org/obo/owl/IMR#IMR_0100737
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
Phosphorylation of GSK3beta by AKT in cytosol
event
PubMed:11278246
http://purl.org/obo/owl/PubMed#PubMed_11278246
IMR:0100737
http://purl.org/obo/owl/IMR#IMR_0100737
IMR:0000250
http://purl.org/obo/owl/IMR#IMR_0000250
GSK3beta inactivation signaling
event
AKT(PKB)-GSK3beta signaling
event
Regulation of EPO signaling pathway
event
Negative regulation of EPO signaling pathway
event
Positive regulation of EPO signaling pathway
event
Regulation of Growth hormone signaling pathway (JAK2 STAT5)
event
Negative regulation of Growth hormone signaling pathway (JAK2 STAT5)
event
Positive regulation of Growth hormone signaling pathway (JAK2 STAT5)
event
Regulation of JAK STAT signaling (Angiotensin induced)
event
Regulation of JAK STAT signaling pathway (Angiotensin induced)
Negative regulation of JAK STAT signaling (Angiotensin induced)
event
Negative regulation of JAK STAT signaling pathway (Angiotensin induced)
Positive regulation of JAK STAT signaling (Angiotensin induced)
event
Positive regulation of JAK STAT signaling pathway (Angiotensin induced)
Regulation of TPO signaling pathway (through JAK STAT pathway)
event
Negative regulation of TPO signaling pathway (through JAK STAT pathway)
event
Positive regulation of TPO signaling pathway (through JAK STAT pathway)
event
Sumoylation of Smad3 by PIAS4 in cytosol
event
PubMed:12815042
http://purl.org/obo/owl/PubMed#PubMed_12815042
IMR:0100312
http://purl.org/obo/owl/IMR#IMR_0100312
IMR:0002926
http://purl.org/obo/owl/IMR#IMR_0002926
Negative feedback regulation pathway of TGF beta superfamily signaling by (Smad3 sumoylation by PIAS)
event
IMR:0100312
http://purl.org/obo/owl/IMR#IMR_0100312
IMR:0002914
http://purl.org/obo/owl/IMR#IMR_0002914
Gene expression of PIAS4 (induced by TGF-beta)
event
Hep3B cells
PubMed:12815042
http://purl.org/obo/owl/PubMed#PubMed_12815042
PubMed:12815042
http://purl.org/obo/owl/PubMed#PubMed_12815042
IMR:0002926
http://purl.org/obo/owl/IMR#IMR_0002926
Sumoylation of STAT1 by PIAS in nucleus
event
IMR:0002914
http://purl.org/obo/owl/IMR#IMR_0002914
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
PubMed:12855578
http://purl.org/obo/owl/PubMed#PubMed_12855578
Negative regulation of JAK STAT pathway by (sumoylation of STAT by PIAS1/3)
event
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
IMR:0002915
http://purl.org/obo/owl/IMR#IMR_0002915
Binding of Androgen and Androgen receptor in inner space of nucleus
event
IMR:0100035
http://purl.org/obo/owl/IMR#IMR_0100035
UniProt:P10275
http://purl.org/obo/owl/UniProt#UniProt_P10275
Binding of Androgen receptor and responsive element in inner space of nucleus
event
IGS:0000028
http://purl.org/obo/owl/IGS#IGS_0000028
UniProt:P10275
http://purl.org/obo/owl/UniProt#UniProt_P10275
Nuclear import of Androgen
event
IMR:0100035
http://purl.org/obo/owl/IMR#IMR_0100035
Transcription by Androgen receptor in nucleus
event
UniProt:P10275
http://purl.org/obo/owl/UniProt#UniProt_P10275
Translocation of Androgen from extracellular to cytosol
event
IMR:0100035
http://purl.org/obo/owl/IMR#IMR_0100035
Binding of Androgen receptor and Hsp90 in cytosol
event
UniProt:P10275
http://purl.org/obo/owl/UniProt#UniProt_P10275
Nuclear import of Androgen receptor:Hsp90
event
UniProt:P10275
http://purl.org/obo/owl/UniProt#UniProt_P10275
Regulation of Steroid receptor signaling
event
Regulation of Steroid receptor signaling pathway
Negative regulation of Steroid receptor signaling pathway
event
Positive regulation of Steroid receptor signaling pathway
event
Regulation of Estrogen receptor signaling pathway
event
GO:0033146
http://purl.org/obo/owl/GO#GO_0033146
Any process that modulates the frequency, rate or extent of the activity of an estrogen receptor signaling pathway.
GO:0033146
http://purl.org/obo/owl/GO#GO_0033146
Regulation of Androgen receptor signaling pathway
event
Negative regulation of Androgen receptor signaling pathway
event
Positive regulation of Androgen receptor signaling pathway
event
Negative regulation of Estrogen receptor signaling pathway
event
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an estrogen receptor signaling pathway.
GO:0033147
http://purl.org/obo/owl/GO#GO_0033147
GO:0033147
http://purl.org/obo/owl/GO#GO_0033147
Positive regulation of Estrogen receptor signaling pathway
event
Any process that activates or increases the frequency, rate or extent of the activity of an estrogen receptor signaling pathway.
GO:0033148
http://purl.org/obo/owl/GO#GO_0033148
GO:0033148
http://purl.org/obo/owl/GO#GO_0033148
Binding of Androgen receptor and PIAS4 in cytosol and/or nucleus
event
PubMed:14981544
http://purl.org/obo/owl/PubMed#PubMed_14981544
IMR:0002926
http://purl.org/obo/owl/IMR#IMR_0002926
UniProt:P10275
http://purl.org/obo/owl/UniProt#UniProt_P10275
Negative regulation of Androgen receptor signaling pathway by PIAS-mediated repression of Androgen receptor
event
Sumoylation of Androgen receptor by PIAS4
event
IMR:0002926
http://purl.org/obo/owl/IMR#IMR_0002926
PubMed:14981544
http://purl.org/obo/owl/PubMed#PubMed_14981544
UniProt:P10275
http://purl.org/obo/owl/UniProt#UniProt_P10275
Binding of Androgen receptor and HDAC in inner space of nucleus
event
IMR:0001166
http://purl.org/obo/owl/IMR#IMR_0001166
PubMed:14981544
http://purl.org/obo/owl/PubMed#PubMed_14981544
UniProt:P10275
http://purl.org/obo/owl/UniProt#UniProt_P10275
Homodimerization of Androgen receptor in inner space of nucleus
event
UniProt:P10275
http://purl.org/obo/owl/UniProt#UniProt_P10275
Homodimerization of Estrogen receptor in inner space of nucleus
event
IMR:0000088
http://purl.org/obo/owl/IMR#IMR_0000088
Regulation of calcineurin activation signaling
event
Negative regulation of calcineurin activation signaling
event
Positive regulation of calcineurin activation signaling
event
Binding of calcineurin and FK506
event
IMR:0000278
http://purl.org/obo/owl/IMR#IMR_0000278
KEGG:C01375
http://purl.org/obo/owl/KEGG#KEGG_C01375
Binding of calcineurin and CSK
event
IMR:0000212
http://purl.org/obo/owl/IMR#IMR_0000212
IMR:0000278
http://purl.org/obo/owl/IMR#IMR_0000278
Regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
event
Regulation of CD4 T cell receptor signaling pathway (through PLC gamma, calcineurin and NF-AT)
Negative regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
event
Negative regulation of CD4 T cell receptor signaling pathway (through PLC gamma, calcineurin and NF-AT)
Positive regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
event
IMR:0000421
http://purl.org/obo/owl/IMR#IMR_0000421
Positive regulation of CD4 T cell receptor signaling pathway (through PLC gamma, calcineurin and NF-AT)
Regulation of Bad activation signaling
event
Negative regulation of Bad activation signaling
event
Positive regulation of Bad activation signaling
event
Binding of AKT and Hsp90 in cytosol
event
PubMed:10995457
http://purl.org/obo/owl/PubMed#PubMed_10995457
IMR:0000250
http://purl.org/obo/owl/IMR#IMR_0000250
Dephosphorylation of AKT(PKB) by PP2A
event
IMR:0000250
http://purl.org/obo/owl/IMR#IMR_0000250
IMR:0000280
http://purl.org/obo/owl/IMR#IMR_0000280
PubMed:10995457
http://purl.org/obo/owl/PubMed#PubMed_10995457
Binding of Naked and DSH in cytosol
event
UniProt:Q969G9
http://purl.org/obo/owl/UniProt#UniProt_Q969G9
UniProt:Q969F2
http://purl.org/obo/owl/UniProt#UniProt_Q969F2
IMR:0100755
http://purl.org/obo/owl/IMR#IMR_0100755
Binding of Idax and DSH in cytosol
event
UniProt:Q9H2H0
http://purl.org/obo/owl/UniProt#UniProt_Q9H2H0
IMR:0100755
http://purl.org/obo/owl/IMR#IMR_0100755
TCF phosphorylation signaling
event
Binding of TAB1 and TAK1 in cytosol
event
IMR:0000232
http://purl.org/obo/owl/IMR#IMR_0000232
IMR:0000441
http://purl.org/obo/owl/IMR#IMR_0000441
PubMed:14687659
http://purl.org/obo/owl/PubMed#PubMed_14687659
PubMed:15733830
http://purl.org/obo/owl/PubMed#PubMed_15733830
Phosphorylation of NLK by TAK1 in cytosol
event
IMR:0001164
http://purl.org/obo/owl/IMR#IMR_0001164
IMR:0000232
http://purl.org/obo/owl/IMR#IMR_0000232
Phosphorylation of TCF by NLK in cytosol
event
IMR:0000418
http://purl.org/obo/owl/IMR#IMR_0000418
IMR:0001164
http://purl.org/obo/owl/IMR#IMR_0001164
Negative feedback regulation of Wnt signaling pathway
event
Binding of beta catenin and beta-TrCP in cytosol
event
IMR:0100471
http://purl.org/obo/owl/IMR#IMR_0100471
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
Negative feedback regulation of Wnt signaling pathway (through beta-TrCP)
event
Binding of SFRP and Wnt receptor in extracellular
event
PubMed:15549094
http://purl.org/obo/owl/PubMed#PubMed_15549094
IMR:0000983
http://purl.org/obo/owl/IMR#IMR_0000983
Binding of Wnt and LRP5/6 in extracellular
event
PubMed:15549094
http://purl.org/obo/owl/PubMed#PubMed_15549094
IMR:0000003
http://purl.org/obo/owl/IMR#IMR_0000003
IMR:0002954
http://purl.org/obo/owl/IMR#IMR_0002954
Binding of Wnt and Wnt receptor in extracellular
event
PubMed:15549094
http://purl.org/obo/owl/PubMed#PubMed_15549094
IMR:0000003
http://purl.org/obo/owl/IMR#IMR_0000003
Binding of WIF and Wnt receptor in extracellular
event
PubMed:15549094
http://purl.org/obo/owl/PubMed#PubMed_15549094
IMR:0000989
http://purl.org/obo/owl/IMR#IMR_0000989
Binding of Dkk and Wnt receptor in extracellular
event
IMR:0000991
http://purl.org/obo/owl/IMR#IMR_0000991
PubMed:15549094
http://purl.org/obo/owl/PubMed#PubMed_15549094
Complex formation of beta catenin, TCF/LEF, Legless, Pygopus, etc. in inner space of nucleus
event
IMR:0001179
http://purl.org/obo/owl/IMR#IMR_0001179
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
IMR:0000418
http://purl.org/obo/owl/IMR#IMR_0000418
IMR:0001178
http://purl.org/obo/owl/IMR#IMR_0001178
PubMed:15549094
http://purl.org/obo/owl/PubMed#PubMed_15549094
Blood circulation
event
The flow of blood through the body of an animal, enabling the transport of O2 and nutrients to the tissues and the removal of waste products.
GO:0008015
http://purl.org/obo/owl/GO#GO_0008015
GO:0008015
http://purl.org/obo/owl/GO#GO_0008015
Regulation of blood vessel size
event
GO:0050880
http://purl.org/obo/owl/GO#GO_0050880
Any process that modulates the size of blood vessels.
GO:0050880
http://purl.org/obo/owl/GO#GO_0050880
Vasoconstriction
event
GO:0042310
http://purl.org/obo/owl/GO#GO_0042310
Negative regulation of blood vessel size
GO:0042310
http://purl.org/obo/owl/GO#GO_0042310
A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure.
GO:0042310
http://purl.org/obo/owl/GO#GO_0042310
Muscle cell differentiation
event
The process whereby a relatively unspecialized cell acquires specialized features of a muscle cell.
GO:0042692
http://purl.org/obo/owl/GO#GO_0042692
GO:0042692
http://purl.org/obo/owl/GO#GO_0042692
Smooth muscle cell differentiation
event
nonstriated muscle cell differentiation
GO:0051145
http://purl.org/obo/owl/GO#GO_0051145
The process whereby a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary.
GO:0051145
http://purl.org/obo/owl/GO#GO_0051145
GO:0051145
http://purl.org/obo/owl/GO#GO_0051145
Sumoylation of STAT1/3/4 by PIAS in nucleus
event
IMR:0002914
http://purl.org/obo/owl/IMR#IMR_0002914
PubMed:14607831
http://purl.org/obo/owl/PubMed#PubMed_14607831
IMR:0000378
http://purl.org/obo/owl/IMR#IMR_0000378
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
Sumoylation of STAT1/3/4 by PIAS1/3 in nucleus
event
IMR:0000378
http://purl.org/obo/owl/IMR#IMR_0000378
IMR:0002922
http://purl.org/obo/owl/IMR#IMR_0002922
IMR:0002915
http://purl.org/obo/owl/IMR#IMR_0002915
PubMed:14607831
http://purl.org/obo/owl/PubMed#PubMed_14607831
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
Sumoylation of STAT1/3/4 by PIAS2/4 in nucleus
event
IMR:0002926
http://purl.org/obo/owl/IMR#IMR_0002926
PubMed:14607831
http://purl.org/obo/owl/PubMed#PubMed_14607831
IMR:0000378
http://purl.org/obo/owl/IMR#IMR_0000378
IMR:0002918
http://purl.org/obo/owl/IMR#IMR_0002918
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
SUMOylation in cytosol and/or nucleus
event
SUMOylation in nucleus
event
Sumoylation of trans-activator by PIAS in nucleus
event
PubMed:15021887
http://purl.org/obo/owl/PubMed#PubMed_15021887
IMR:0002914
http://purl.org/obo/owl/IMR#IMR_0002914
Binding of trans-activator and co-repressor in inner space of nucleus
event
PubMed:15021887
http://purl.org/obo/owl/PubMed#PubMed_15021887
Regulation of transcription
event
GO:0045449
http://purl.org/obo/owl/GO#GO_0045449
Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.
GO:0045449
http://purl.org/obo/owl/GO#GO_0045449
Positive regulation of transcription
event
GO:0045941
http://purl.org/obo/owl/GO#GO_0045941
up regulation of transcription
Any process that activates or increases the frequency, rate or extent of transcription.
GO:0045941
http://purl.org/obo/owl/GO#GO_0045941
Regulation of gene expression
event
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
GO:0010468
http://purl.org/obo/owl/GO#GO_0010468
GO:0010468
http://purl.org/obo/owl/GO#GO_0010468
Positive regulation of gene expression
event
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
GO:0010628
http://purl.org/obo/owl/GO#GO_0010628
GO:0010628
http://purl.org/obo/owl/GO#GO_0010628
Negative regulation of gene expression
event
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
GO:0010629
http://purl.org/obo/owl/GO#GO_0010629
GO:0010629
http://purl.org/obo/owl/GO#GO_0010629
Negative regulation of transcription
event
Any process that stops, prevents or reduces the frequency, rate or extent of transcription.
GO:0016481
http://purl.org/obo/owl/GO#GO_0016481
GO:0016481
http://purl.org/obo/owl/GO#GO_0016481
down regulation of transcription
Negative regulation of translation
event
negative regulation of protein biosynthetic process
negative regulation of protein formation
negative regulation of protein anabolism
negative regulation of protein biosynthesis
negative regulation of protein synthesis
down regulation of protein biosynthetic process
Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
GO:0017148
http://purl.org/obo/owl/GO#GO_0017148
GO:0017148
http://purl.org/obo/owl/GO#GO_0017148
Positive regulation of translation
event
positive regulation of protein synthesis
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
GO:0045727
http://purl.org/obo/owl/GO#GO_0045727
positive regulation of protein formation
GO:0045727
http://purl.org/obo/owl/GO#GO_0045727
positive regulation of protein biosynthetic process
positive regulation of protein biosynthesis
positive regulation of protein anabolism
up regulation of protein biosynthetic process
Regulation of translation
event
regulation of protein formation
regulation of protein synthesis
regulation of protein anabolism
regulation of protein biosynthesis
GO:0006417
http://purl.org/obo/owl/GO#GO_0006417
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
GO:0006417
http://purl.org/obo/owl/GO#GO_0006417
Signaling pathway
event
The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms.
GO:0023033
http://purl.org/obo/owl/GO#GO_0023033
GO:0023033
http://purl.org/obo/owl/GO#GO_0023033
Negative regulation of (Phosphorylation of cytokine receptor) in JAK STAT pathway
event
IMR:0000095
http://purl.org/obo/owl/IMR#IMR_0000095
Negative regulation of (Phosphorylation of JAK) in JAK STAT pathway
event
PubMed:14607831
http://purl.org/obo/owl/PubMed#PubMed_14607831
IMR:0000213
http://purl.org/obo/owl/IMR#IMR_0000213
Negative regulation of (Phosphorylation of STAT) in JAK STAT pathway
event
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
Negative regulation of (nuclear import of R-Smad:Smad4) in TGF beta super family signaling pathway
event
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
Positive regulation of (transcription by R-Smad:Smad4 ) in TGF beta super family signaling pathway by (Smad4 sumoylation by PIAS1)
event
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
Negative regulation of (phosphorylation of AKT(PKB)) in AKT(PKB) activation signaling
event
Negative regulation of (dephosphorylation of AKT(PKB)) in negative regulation of AKT(PKB)-Bad signaling
event
Regulation of AKT(PKB)-Bad signaling
event
Negative regulation of AKT(PKB)-Bad signaling
event
Positive regulation of AKT(PKB)-Bad signaling
event
Positive regulation of (phosphorylation of Bad) in AKT(PKB)-Bad signaling
event
Binding of TGF beta and TGF-beta receptor II in extracellular
event
IMR:0000041
http://purl.org/obo/owl/IMR#IMR_0000041
IMR:0000712
http://purl.org/obo/owl/IMR#IMR_0000712
Binding of TGF beta:TGF beta receptor II and TGF beta receptor I in plasma membrane
event
IMR:0000041
http://purl.org/obo/owl/IMR#IMR_0000041
IMR:0000710
http://purl.org/obo/owl/IMR#IMR_0000710
IMR:0000712
http://purl.org/obo/owl/IMR#IMR_0000712
Binding of BMP2 and BMP receptor I in extracellular
event
IMR:0001424
http://purl.org/obo/owl/IMR#IMR_0001424
IMR:0001425
http://purl.org/obo/owl/IMR#IMR_0001425
Negative regulation of (phosphorylation of Bad) in AKT(PKB)-Bad signaling
event
Negative regulation of (phosphorylation of PIP2) in AKT(PKB) activation signaling
event
IMR:0001350
http://purl.org/obo/owl/IMR#IMR_0001350
Regulation of (negative regulation of AKT(PKB) activation signaling)
event
Negative regulation of (negative regulation of AKT(PKB) activation signaling)
event
Negative regulation of (dephosphorylation of AKT(PKB) in negative regulation of AKT(PKB) activation signaling)
event
Positive regulation of (phosphorylation of AKT(PKB) in AKT(PKB) activation signaling
event
Protein nuclear import/export signaling
event
HDAC nuclear import/export signaling
event
HDAC nuclear import signaling
event
HDAC nuclear export signaling
event
Regulation of HDAC nuclear export signaling
event
Positive regulation of HDAC nuclear export signaling
event
Negative regulation of HDAC nuclear export signaling
event
Regulation of HDAC nuclear import signaling
event
Negative regulation of HDAC nuclear import signaling
event
Positive regulation of HDAC nuclear import signaling
event
Dissociation of HDAC5/7 and MEF2 in inner space of nucleus
event
UniProt:Q02078
http://purl.org/obo/owl/UniProt#UniProt_Q02078
IMR:0001173
http://purl.org/obo/owl/IMR#IMR_0001173
IMR:0001171
http://purl.org/obo/owl/IMR#IMR_0001171
Transcription by MEF2 in nucleus
event
UniProt:Q02078
http://purl.org/obo/owl/UniProt#UniProt_Q02078
Negative regulation of transcription in endothelin signaling by histone acetylation
event
Deacetylation of histone by HDAC5/7 in nucleus
event
IMR:0001171
http://purl.org/obo/owl/IMR#IMR_0001171
PubMed:11585834
http://purl.org/obo/owl/PubMed#PubMed_11585834
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
IMR:0001173
http://purl.org/obo/owl/IMR#IMR_0001173
Binding of HDAC5 and importin alpha in cytosol
event
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
IMR:0100202
http://purl.org/obo/owl/IMR#IMR_0100202
IMR:0001171
http://purl.org/obo/owl/IMR#IMR_0001171
Heparan sulfate biosynthesis
event
KEGG:map00534
http://purl.org/obo/owl/KEGG#KEGG_map00534
Deacetylation of histone by HDAC5 in nucleus
event
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
IMR:0001171
http://purl.org/obo/owl/IMR#IMR_0001171
Deacetylation of histone by HDAC7 in nucleus
event
IMR:0001173
http://purl.org/obo/owl/IMR#IMR_0001173
PubMed:11585834
http://purl.org/obo/owl/PubMed#PubMed_11585834
Tryptophan biosynthesis
event
KEGG:map00400
http://purl.org/obo/owl/KEGG#KEGG_map00400
tryptophan biosynthetic process
GO:0000162
http://purl.org/obo/owl/GO#GO_0000162
tryptophan anabolism
The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.
GO:0000162
http://purl.org/obo/owl/GO#GO_0000162
tryptophan formation
tryptophan synthesis
Nuclear import of HDAC5
event
PubMed:11509672
http://purl.org/obo/owl/PubMed#PubMed_11509672
IMR:0001171
http://purl.org/obo/owl/IMR#IMR_0001171
Nuclear import of HDAC7
event
IMR:0001173
http://purl.org/obo/owl/IMR#IMR_0001173
PubMed:11585834
http://purl.org/obo/owl/PubMed#PubMed_11585834
Dissociation of HDAC7 and MEF2 in inner space of nucleus
event
IMR:0001173
http://purl.org/obo/owl/IMR#IMR_0001173
UniProt:Q02078
http://purl.org/obo/owl/UniProt#UniProt_Q02078
Dissociation of HDAC5 and MEF2 in inner space of nucleus
event
IMR:0001171
http://purl.org/obo/owl/IMR#IMR_0001171
UniProt:Q02078
http://purl.org/obo/owl/UniProt#UniProt_Q02078
Molecular interaction
IEV:0000220
event
IEV:0000922
Unknown process
Unknown interaction
Phosphorylation of Fyn by Csk and inactive conformational change in cytosol
event
IMR:0100352
http://purl.org/obo/owl/IMR#IMR_0100352
IMR:0000212
http://purl.org/obo/owl/IMR#IMR_0000212
Negative regulation of (Autophosphorylation of Fyn) in Fyn activation signaling
event
IMR:0100352
http://purl.org/obo/owl/IMR#IMR_0100352
Negative regulation of (dephosphorylation of Fyn) in Fyn activation signaling
event
IMR:0100352
http://purl.org/obo/owl/IMR#IMR_0100352
Lck inactivation signaling (through Csk)
event
Fyn inactivation signaling (through Csk)
event
Src inactivation signaling (through PTP)
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Src inactivation signaling (through non-receptor kinase)
event
Negative regulation of (phosphorylation of Lck) Lck activation signaling (autophosphorylation and PTP)
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Phosphorylation of Lck by Csk and inactive conformational change in cytosol
event
IMR:0000212
http://purl.org/obo/owl/IMR#IMR_0000212
IMR:0100353
http://purl.org/obo/owl/IMR#IMR_0100353
Negative regulation of Lck activation signaling (autophosphorylation and PTP)
event
IMR:0000273
http://purl.org/obo/owl/IMR#IMR_0000273
Binding of phosphatidylserine and PKC and active conformational change of PKC in plasma membrane
event
PubMed:7499357
http://purl.org/obo/owl/PubMed#PubMed_7499357
IMR:0001358
http://purl.org/obo/owl/IMR#IMR_0001358
IMR:0000245
http://purl.org/obo/owl/IMR#IMR_0000245
Binding of phosphatidylserine and cPKC and active conformational change of cPKC in plasma membrane
event
PubMed:7499357
http://purl.org/obo/owl/PubMed#PubMed_7499357
IMR:0100486
http://purl.org/obo/owl/IMR#IMR_0100486
IMR:0001358
http://purl.org/obo/owl/IMR#IMR_0001358
Binding of phosphatidylserine and PKC theta and active conformational change of PKC theta in plasma membrane
event
PubMed:7499357
http://purl.org/obo/owl/PubMed#PubMed_7499357
IMR:0100484
http://purl.org/obo/owl/IMR#IMR_0100484
IMR:0001358
http://purl.org/obo/owl/IMR#IMR_0001358
Regulation of cPKC activation signaling
event
Negative regulation of cPKC activation signaling
event
Positive regulation of cPKC activation signaling
event
Negative regulation of (binding of calcium ion and cPKC) in cPKC activation signaling
event
IMR:0100031
http://purl.org/obo/owl/IMR#IMR_0100031
Negative regulation of (binding of DAG and cPKC) in cPKC activation signaling
event
Negative regulation of (binding of phosphatidylserine and cPKC) in cPKC activation signaling
event
IMR:0001358
http://purl.org/obo/owl/IMR#IMR_0001358
Dissociation of calcium ion and cPKC
event
IMR:0100031
http://purl.org/obo/owl/IMR#IMR_0100031
IMR:0100486
http://purl.org/obo/owl/IMR#IMR_0100486
Dissociation of DAG and cPKC
event
IMR:0100486
http://purl.org/obo/owl/IMR#IMR_0100486
IMR:0100027
http://purl.org/obo/owl/IMR#IMR_0100027
Dissociation of phosphatidylserine and cPKC in plasma membrane
event
IMR:0100486
http://purl.org/obo/owl/IMR#IMR_0100486
IMR:0001358
http://purl.org/obo/owl/IMR#IMR_0001358
PubMed:7499357
http://purl.org/obo/owl/PubMed#PubMed_7499357
Regulation of PKC activation signaling
event
Positive regulation of PKC activation signaling
event
Negative regulation of PKC activation signaling
event
Regulation of PKC theta activation signaling
event
Negative regulation of PKC theta activation signaling
event
Positive regulation of PKC theta activation signaling
event
Negative regulation of (binding of DAG and PKC theta) in PKC theta activation signaling
event
Negative regulation of (binding of phosphatidylserine and PKC theta) in PKC theta activation signaling
event
IMR:0001358
http://purl.org/obo/owl/IMR#IMR_0001358
Dissociation of DAG and PKC theta
event
IMR:0100027
http://purl.org/obo/owl/IMR#IMR_0100027
IMR:0100484
http://purl.org/obo/owl/IMR#IMR_0100484
Dissociation of phosphatidylserine and PKC theta in plasma membrane
event
IMR:0100484
http://purl.org/obo/owl/IMR#IMR_0100484
IMR:0001358
http://purl.org/obo/owl/IMR#IMR_0001358
Negative regulation of (binding of calcium ion and PKC) in PKC activation signaling
event
IMR:0100031
http://purl.org/obo/owl/IMR#IMR_0100031
Negative regulation of (binding of DAG and PKC) in PKC activation signaling
event
Negative regulation of (binding of phosphatidylserine and PKC) in PKC activation signaling
event
IMR:0001358
http://purl.org/obo/owl/IMR#IMR_0001358
Dissociation of calcium ion and PKC
event
IMR:0000245
http://purl.org/obo/owl/IMR#IMR_0000245
IMR:0100031
http://purl.org/obo/owl/IMR#IMR_0100031
Dissociation of DAG and PKC
event
IMR:0100027
http://purl.org/obo/owl/IMR#IMR_0100027
IMR:0000245
http://purl.org/obo/owl/IMR#IMR_0000245
Dissociation of phosphatidylserine and PKC in plasma membrane
event
IMR:0000245
http://purl.org/obo/owl/IMR#IMR_0000245
IMR:0001358
http://purl.org/obo/owl/IMR#IMR_0001358
PubMed:7499357
http://purl.org/obo/owl/PubMed#PubMed_7499357
Regulation of PKA activation signaling
event
Negative regulation of PKA activation signaling
event
Positive regulation of PKA activation signaling
event
Negative feedback regulation of p53 degradation signaling
event
Binding of Mdm2 and p14ARF in inner space of nucleus
event
IMR:0701007
http://purl.org/obo/owl/IMR#IMR_0701007
PubMed:15021897
http://purl.org/obo/owl/PubMed#PubMed_15021897
IMR:0100660
http://purl.org/obo/owl/IMR#IMR_0100660
Ubiquitination of Mdm4 by Mdm2 in nucleus
event
UniProt:O15151
http://purl.org/obo/owl/UniProt#UniProt_O15151
IMR:0100660
http://purl.org/obo/owl/IMR#IMR_0100660
Proteasome degradation of Mdm4 in cytosol
event
UniProt:O15151
http://purl.org/obo/owl/UniProt#UniProt_O15151
Ubiquitination of p53 by ubiquitin ligase in nucleus
event
IMR:0000329
http://purl.org/obo/owl/IMR#IMR_0000329
PubMed:15021897
http://purl.org/obo/owl/PubMed#PubMed_15021897
IMR:0100659
http://purl.org/obo/owl/IMR#IMR_0100659
Binding of Mdm2 and Mdm4 in inner space of nucleus
event
PubMed:12860999
http://purl.org/obo/owl/PubMed#PubMed_12860999
UniProt:O15151
http://purl.org/obo/owl/UniProt#UniProt_O15151
IMR:0100660
http://purl.org/obo/owl/IMR#IMR_0100660
Binding of Mdm2 and ARF in inner space of nucleus
event
IMR:0100660
http://purl.org/obo/owl/IMR#IMR_0100660
IMR:0000447
http://purl.org/obo/owl/IMR#IMR_0000447
PubMed:15021897
http://purl.org/obo/owl/PubMed#PubMed_15021897
PubMed:12860999
http://purl.org/obo/owl/PubMed#PubMed_12860999
Nuclear import of Mdm4
event
UniProt:O15151
http://purl.org/obo/owl/UniProt#UniProt_O15151
PubMed:12860999
http://purl.org/obo/owl/PubMed#PubMed_12860999
Palmitoylation of Wnt by Porcupine in ER
event
IMR:0000981
http://purl.org/obo/owl/IMR#IMR_0000981
IMR:0000003
http://purl.org/obo/owl/IMR#IMR_0000003
PubMed:8985181
http://purl.org/obo/owl/PubMed#PubMed_8985181
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
PubMed:15166250
http://purl.org/obo/owl/PubMed#PubMed_15166250
Palmitoylation in ER
event
Translocation of Wnt from ER to extracellular space
event
IMR:0000003
http://purl.org/obo/owl/IMR#IMR_0000003
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
Translocation from ER to extracellular space
event
Translocation of Arrow/LRP5/6 from ER to plasma membrane
event
PubMed:12581524
http://purl.org/obo/owl/PubMed#PubMed_12581524
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
IMR:0002951
http://purl.org/obo/owl/IMR#IMR_0002951
Translocation from ER to plasma membrane
event
Translocation from cytosol to plasma membrane
event
IEV:0002197
Translocation from cytosol to plasma membrane
Translocation from ER to cytosol
event
IEV:0000275
Translocation from the ER to the cytosol
Translocation of LRP6 from ER to plasma membrane
event
IMR:0000970
http://purl.org/obo/owl/IMR#IMR_0000970
Translocation of Arrow/LRP5/6 from ER to cytosol
event
IMR:0002951
http://purl.org/obo/owl/IMR#IMR_0002951
Translocation of Arrow/LRP5/6 from cytosol to plasma membrane
event
IMR:0002951
http://purl.org/obo/owl/IMR#IMR_0002951
Translocation of LRP6 from cytosol to plasma membrane
event
IMR:0000970
http://purl.org/obo/owl/IMR#IMR_0000970
Translocation of LRP6 from ER to cytosol
event
IMR:0000970
http://purl.org/obo/owl/IMR#IMR_0000970
Binding of Wnt, Frizzled and Arrow/LRP5/6 in extracellular
event
PubMed:11029006
http://purl.org/obo/owl/PubMed#PubMed_11029006
IMR:0002951
http://purl.org/obo/owl/IMR#IMR_0002951
IMR:0000055
http://purl.org/obo/owl/IMR#IMR_0000055
IMR:0000003
http://purl.org/obo/owl/IMR#IMR_0000003
PubMed:8717036
http://purl.org/obo/owl/PubMed#PubMed_8717036
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
PubMed:12205098
http://purl.org/obo/owl/PubMed#PubMed_12205098
PubMed:11029007
http://purl.org/obo/owl/PubMed#PubMed_11029007
Phosphorylation of Arrow/LRP5/6 in cytosol
event
IMR:0002951
http://purl.org/obo/owl/IMR#IMR_0002951
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
PubMed:11029007
http://purl.org/obo/owl/PubMed#PubMed_11029007
PubMed:14731402
http://purl.org/obo/owl/PubMed#PubMed_14731402
Binding of Arrow/LRP5/6 and Axin in cytosol
event
IMR:0000432
http://purl.org/obo/owl/IMR#IMR_0000432
PubMed:11336703
http://purl.org/obo/owl/PubMed#PubMed_11336703
IMR:0002951
http://purl.org/obo/owl/IMR#IMR_0002951
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
PubMed:14731402
http://purl.org/obo/owl/PubMed#PubMed_14731402
PubMed:1236921
http://purl.org/obo/owl/PubMed#PubMed_1236921
Binding of Dsh and Axin in cytosol
event
IMR:0000432
http://purl.org/obo/owl/IMR#IMR_0000432
IMR:0100755
http://purl.org/obo/owl/IMR#IMR_0100755
PubMed:10688669
http://purl.org/obo/owl/PubMed#PubMed_10688669
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
Binding of Dsh and GBP/Frat and GSK-3 in cytosol
event
PubMed:10428961
http://purl.org/obo/owl/PubMed#PubMed_10428961
PubMed:10684251
http://purl.org/obo/owl/PubMed#PubMed_10684251
PubMed:10882137
http://purl.org/obo/owl/PubMed#PubMed_10882137
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
PubMed:9635432
http://purl.org/obo/owl/PubMed#PubMed_9635432
IMR:0100755
http://purl.org/obo/owl/IMR#IMR_0100755
IMR:0000257
http://purl.org/obo/owl/IMR#IMR_0000257
IMR:0001247
http://purl.org/obo/owl/IMR#IMR_0001247
Complex formation of Axin, APC, GSK-3, Beta catenin and PP2A in cytosol
event
IMR:0000280
http://purl.org/obo/owl/IMR#IMR_0000280
IMR:0000257
http://purl.org/obo/owl/IMR#IMR_0000257
IMR:0000205
http://purl.org/obo/owl/IMR#IMR_0000205
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
IMR:0000432
http://purl.org/obo/owl/IMR#IMR_0000432
Dephosphorylation of beta-catenin by PP2A in cytosol
event
IMR:0000280
http://purl.org/obo/owl/IMR#IMR_0000280
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
Binding of Pygopus, Legless and beta-catenin:TCF complex in inner space of nucleus
event
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
IMR:0001179
http://purl.org/obo/owl/IMR#IMR_0001179
IMR:0001178
http://purl.org/obo/owl/IMR#IMR_0001178
IMR:0000418
http://purl.org/obo/owl/IMR#IMR_0000418
Binding of CBP and beta-catenin in inner space of nucleus
event
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
IMR:0000426
http://purl.org/obo/owl/IMR#IMR_0000426
Binding of Brg1 and beta-catenin:TCF complex in inner space of nucleus
event
IMR:0001951
http://purl.org/obo/owl/IMR#IMR_0001951
IMR:0000418
http://purl.org/obo/owl/IMR#IMR_0000418
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
Binding of Wnt and WIF in extracellular
event
IMR:0000003
http://purl.org/obo/owl/IMR#IMR_0000003
IMR:0000989
http://purl.org/obo/owl/IMR#IMR_0000989
Binding of Wnt and SFRP in extracellular
event
IMR:0000003
http://purl.org/obo/owl/IMR#IMR_0000003
IMR:0000983
http://purl.org/obo/owl/IMR#IMR_0000983
Binding of Dkk, Arrow/LRP5/6 and Kremen in extracellular
event
IMR:0000991
http://purl.org/obo/owl/IMR#IMR_0000991
IMR:0002951
http://purl.org/obo/owl/IMR#IMR_0002951
IMR:0000996
http://purl.org/obo/owl/IMR#IMR_0000996
Binding of Dkk1, LRP6 and Kremen2 in extracellular
event
IMR:0000970
http://purl.org/obo/owl/IMR#IMR_0000970
IMR:0000992
http://purl.org/obo/owl/IMR#IMR_0000992
IMR:0000998
http://purl.org/obo/owl/IMR#IMR_0000998
Binding of Dkk2, Arrow/LRP5/6 and Kremen2 in extracellular
event
IMR:0002951
http://purl.org/obo/owl/IMR#IMR_0002951
IMR:0000998
http://purl.org/obo/owl/IMR#IMR_0000998
IMR:0000993
http://purl.org/obo/owl/IMR#IMR_0000993
Binding of Wise and Arrow/LRP5/6 in extracellular
event
IMR:0002951
http://purl.org/obo/owl/IMR#IMR_0002951
IMR:0001162
http://purl.org/obo/owl/IMR#IMR_0001162
Internalization of Arrow/LRP5/6
event
IMR:0002951
http://purl.org/obo/owl/IMR#IMR_0002951
Internalization of LRP6
event
IMR:0000970
http://purl.org/obo/owl/IMR#IMR_0000970
Complex formation of Axin, APC, GSK-3 and Beta catenin in cytosol
event
IMR:0000432
http://purl.org/obo/owl/IMR#IMR_0000432
IMR:0000257
http://purl.org/obo/owl/IMR#IMR_0000257
IMR:0000205
http://purl.org/obo/owl/IMR#IMR_0000205
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
Complex formation of Axin, APC, GSK-3, CK1alpha and beta catenin in cytosol
event
IMR:0000257
http://purl.org/obo/owl/IMR#IMR_0000257
IMR:0100810
http://purl.org/obo/owl/IMR#IMR_0100810
IMR:0000432
http://purl.org/obo/owl/IMR#IMR_0000432
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
IMR:0000205
http://purl.org/obo/owl/IMR#IMR_0000205
Phosphorylation of beta-catenin by CK1alpha in cytosol
event
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
IMR:0100810
http://purl.org/obo/owl/IMR#IMR_0100810
Phosphorylation of beta-catenin by GSK-3 in cytosol
event
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
IMR:0000257
http://purl.org/obo/owl/IMR#IMR_0000257
Ubiquitination of beta-catenin by SCF ubiquitin ligase complex in cytosol
event
IEV:0001740
IMR:0100470
http://purl.org/obo/owl/IMR#IMR_0100470
Ubiquitination of beta catenin
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
Binding of Chibby and beta-catenin in inner space of nucleus
event
IMR:0001159
http://purl.org/obo/owl/IMR#IMR_0001159
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
Binding of ICAT and beta-catenin in inner space of nucleus
event
IMR:0001161
http://purl.org/obo/owl/IMR#IMR_0001161
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
Phosphorylation of TCF by NLK in inner space of nucleus
event
IMR:0001164
http://purl.org/obo/owl/IMR#IMR_0001164
IMR:0000418
http://purl.org/obo/owl/IMR#IMR_0000418
Binding of Groucho and TCF in inner space of nucleus
event
IMR:0000418
http://purl.org/obo/owl/IMR#IMR_0000418
IMR:0100748
http://purl.org/obo/owl/IMR#IMR_0100748
Nuclear export of TCF
event
IMR:0000418
http://purl.org/obo/owl/IMR#IMR_0000418
Binding of IRS and PI3K in cytosol
event
IMR:0000265
http://purl.org/obo/owl/IMR#IMR_0000265
IMR:0000351
http://purl.org/obo/owl/IMR#IMR_0000351
PubMed:11282018
http://purl.org/obo/owl/PubMed#PubMed_11282018
PI3K activation signaling (through Estrogen receptor)
event
PI3K activation signaling (through IRS)
event
Dissociation of IRAK1_p and TRAF6 in cytosol
event
IMR:0000890
http://purl.org/obo/owl/IMR#IMR_0000890
PubMed:12620219
http://purl.org/obo/owl/PubMed#PubMed_12620219
IMR:0100427
http://purl.org/obo/owl/IMR#IMR_0100427
Binding of G alpha-GDP and G beta:G gamma in cytosol
event
IMR:0000316
http://purl.org/obo/owl/IMR#IMR_0000316
IMR:0100018
http://purl.org/obo/owl/IMR#IMR_0100018
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
Binding of G alpha s-GDP and G beta:G gamma in cytosol
event
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0100366
http://purl.org/obo/owl/IMR#IMR_0100366
IMR:0100018
http://purl.org/obo/owl/IMR#IMR_0100018
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
Binding of GPCR and G alpha in cytosol
event
IMR:0000316
http://purl.org/obo/owl/IMR#IMR_0000316
IMR:0000137
http://purl.org/obo/owl/IMR#IMR_0000137
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
Binding of GPCR and G alpha s in cytosol
event
IMR:0100366
http://purl.org/obo/owl/IMR#IMR_0100366
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
IMR:0000137
http://purl.org/obo/owl/IMR#IMR_0000137
Binding of G beta:G gamma and PI3K gamma
Free Gbetagamma can directly bind the regulatory p101 of PI3K gamma, leading to PI3K activation.
event
IMR:0100018
http://purl.org/obo/owl/IMR#IMR_0100018
IMR:0200776
http://purl.org/obo/owl/IMR#IMR_0200776
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
PI3K gamma activation singlaing
event
cAMP mediated signaling
event
cAMP signaling
cAMP-mediated signaling
cyclic AMP-mediated signaling
3',5'-cAMP-mediated signaling
adenosine 3',5'-cyclophosphate-mediated signaling
3',5' cAMP-mediated signaling
A series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
GO:0019933
http://purl.org/obo/owl/GO#GO_0019933
GO:0019933
http://purl.org/obo/owl/GO#GO_0019933
Epac activation signaling
Epac:Rap guanine nucleotide exchange factor by cAMP.
event
Cyclic nucleotide-gated cannel activation signaling
event
Phosphorylation of PI3K by JAK3_p in cytosol
event
IMR:0000265
http://purl.org/obo/owl/IMR#IMR_0000265
IMR:0100321
http://purl.org/obo/owl/IMR#IMR_0100321
Binding of G alpha s-GTP and effector in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0100366
http://purl.org/obo/owl/IMR#IMR_0100366
Binding of G alpha s-GTP and Src family in cytosol
event
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
IMR:0100366
http://purl.org/obo/owl/IMR#IMR_0100366
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000211
http://purl.org/obo/owl/IMR#IMR_0000211
Binding of G beta gamma and GRK2/3
event
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
Binding of G beta gamma and calcium ion channel
event
Binding of G beta gamma and sodium ion channel
event
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
Binding of G alpha i-GTP and effector in cytosol
event
IMR:0000319
http://purl.org/obo/owl/IMR#IMR_0000319
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Binding of G alpha o-GTP and effector in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000320
http://purl.org/obo/owl/IMR#IMR_0000320
Binding of G alpha i-GTP and PLC beta
event
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
Binding of G alpha 11-GTP and PLC beta in cytosol
event
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
IMR:0100375
http://purl.org/obo/owl/IMR#IMR_0100375
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000286
http://purl.org/obo/owl/IMR#IMR_0000286
Binding of G alpha 12/13-GTP and RhoGEF in cytosol
event
IMR:0000324
http://purl.org/obo/owl/IMR#IMR_0000324
IMR:0001954
http://purl.org/obo/owl/IMR#IMR_0001954
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
Negative regulation of (Binding of G alpha s-GTP and adenylate cyclase)
event
IMR:0000313
http://purl.org/obo/owl/IMR#IMR_0000313
G alpha s GDP-GTP exchange signaling
event
G alpha s activation signaling
Negative regulation of (G alpha s GDP-GTP exchange signaling)
event
Regulation of heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
event
Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
event
Positive regulation of heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
event
Regulation of G alpha s-GTP hydrolysis signaling
event
Negative regulation of G alpha s-GTP hydrolysis signaling
event
Positive regulation of G alpha s-GTP hydrolysis signaling
event
Negative regulation of (Hydrolysis of GTP by G alpha s-GTP and RGS) (through G alpha s GDP-GTP exchange signaling)
event
IMR:0000431
http://purl.org/obo/owl/IMR#IMR_0000431
G alpha GDP-GTP exchange signaling
event
Binding of G alpha t-GTP and effector in cytosol
event
IMR:0000321
http://purl.org/obo/owl/IMR#IMR_0000321
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Binding of G alpha 11-GTP and effector in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0100375
http://purl.org/obo/owl/IMR#IMR_0100375
Binding of G alpha 12/13-GTP and PLC beta in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000324
http://purl.org/obo/owl/IMR#IMR_0000324
IMR:0000286
http://purl.org/obo/owl/IMR#IMR_0000286
Binding of G alpha q-GTP and effector in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0100378
http://purl.org/obo/owl/IMR#IMR_0100378
G alpha i GDP-GTP exchange signaling
event
Binding of GPCR and G alpha i in cytosol
event
IMR:0000319
http://purl.org/obo/owl/IMR#IMR_0000319
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
IMR:0000137
http://purl.org/obo/owl/IMR#IMR_0000137
Binding of G alpha i-GDP and G beta:G gamma in cytosol
event
IMR:0000319
http://purl.org/obo/owl/IMR#IMR_0000319
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0100018
http://purl.org/obo/owl/IMR#IMR_0100018
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
Negative regulation of (Binding of G alpha i-GTP and adenylate cyclase)
event
IMR:0000313
http://purl.org/obo/owl/IMR#IMR_0000313
Adenylate cyclase activation signaling
event
Any process that initiates the activity of the inactive enzyme adenylate cyclase.
GO:0007190
http://purl.org/obo/owl/GO#GO_0007190
GO:0007190
http://purl.org/obo/owl/GO#GO_0007190
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
adenylate cyclase activation
Adenylate cyclase inactivation signaling
event
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
Positive regulation of G alpha i-GTP hydrolysis signaling
event
Regulation of G alpha i-GTP hydrolysis signaling
event
Positive regulation of heteromeric GPCR signaling pathway (through G alpha i and pertussis toxin)
event
Negative regulation of heteromeric GPCR signaling pathway (through G alpha i)
event
Negative regulation of (Binding of GPCR and G alpha i)
event
cAMP concentration elevation
event
cAMP concentration decline
event
Negative regulation of (Binding of GPCR ligand and GPCR)
event
IMR:0000137
http://purl.org/obo/owl/IMR#IMR_0000137
G alpha q GDP-GTP exchange signaling
event
Binding of G alpha q-GDP and G beta:G gamma in cytosol
event
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
IMR:0100378
http://purl.org/obo/owl/IMR#IMR_0100378
IMR:0100018
http://purl.org/obo/owl/IMR#IMR_0100018
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
Negative regulation of G alpha i-GTP hydrolysis signaling
event
Negative regulation of (Hydrolysis of GTP by G alpha i-GTP and RGS)
event
IMR:0000431
http://purl.org/obo/owl/IMR#IMR_0000431
Regulation of G alpha q-GTP hydrolysis signaling
event
Negative regulation of G alpha q-GTP hydrolysis signaling
event
Negative regulation of (Hydrolysis of GTP by G alpha q-GTP and RGS)
event
IMR:0000431
http://purl.org/obo/owl/IMR#IMR_0000431
IMR:0100378
http://purl.org/obo/owl/IMR#IMR_0100378
Positive regulation of G alpha q-GTP hydrolysis signaling
event
Regulation of G alpha t-GTP hydrolysis signaling
event
Positive regulation of G alpha t-GTP hydrolysis signaling
event
Negative regulation of G alpha t-GTP hydrolysis signaling
event
Negative regulation of (Hydrolysis of GTP by G alpha t-GTP and RGS)
event
IMR:0000431
http://purl.org/obo/owl/IMR#IMR_0000431
G alpha t GDP-GTP exchange signaling
event
Regulation of G alpha GDP-GTP exchange signaling
event
Regulation of G alpha s GDP-GTP exchange signaling
event
Negative regulation of G alpha GDP-GTP exchange signaling
event
Positive regulation of G alpha GDP-GTP exchange signaling
event
Regulation of G alpha i GDP-GTP exchange signaling
event
Regulation of G alpha q GDP-GTP exchange signaling
event
Regulation of G alpha t GDP-GTP exchange signaling
event
Negative regulation of G alpha i GDP-GTP exchange signaling
event
Negative regulation of G alpha q GDP-GTP exchange signaling
event
Negative regulation of G alpha s GDP-GTP exchange signaling
event
Negative regulation of G alpha t GDP-GTP exchange signaling
event
Positive regulation of G alpha i GDP-GTP exchange signaling
event
Positive regulation of G alpha q GDP-GTP exchange signaling
event
Positive regulation of G alpha s GDP-GTP exchange signaling
event
Positive regulation of G alpha t GDP-GTP exchange signaling
event
Negative regulation of (GDP-GTP exchange of G alpha)
event
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
Negative regulation of (GDP-GTP exchange of G alpha i)
event
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
Negative regulation of (GDP-GTP exchange of G alpha q)
event
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0100378
http://purl.org/obo/owl/IMR#IMR_0100378
Negative regulation of (GDP-GTP exchange of G alpha s)
event
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
Negative regulation of (GDP-GTP exchange of G alpha t)
event
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
Binding of GPCR and G alpha q in cytosol
event
IMR:0000137
http://purl.org/obo/owl/IMR#IMR_0000137
IMR:0100378
http://purl.org/obo/owl/IMR#IMR_0100378
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
Binding of GPCR and G alpha t in cytosol
event
PubMed:14734786
http://purl.org/obo/owl/PubMed#PubMed_14734786
IMR:0000321
http://purl.org/obo/owl/IMR#IMR_0000321
IMR:0000137
http://purl.org/obo/owl/IMR#IMR_0000137
Negative regulation of (Hydrolysis of GTP by G alpha s-GTP and RGS) (through Adenylate cyclase activation signaling)
event
IMR:0000431
http://purl.org/obo/owl/IMR#IMR_0000431
Phosphorylation of MAPK by MEK in cytosol
event
IMR:0000259
http://purl.org/obo/owl/IMR#IMR_0000259
IMR:0000224
http://purl.org/obo/owl/IMR#IMR_0000224
Activation of B-Raf by Rap1 in cytosol
event
PubMed:11752597
http://purl.org/obo/owl/PubMed#PubMed_11752597
IMR:0001504
http://purl.org/obo/owl/IMR#IMR_0001504
IMR:0000675
http://purl.org/obo/owl/IMR#IMR_0000675
PubMed:9247123
http://purl.org/obo/owl/PubMed#PubMed_9247123
Binding of Rap1 and B-Raf in cytosol
event
PubMed:9560161
http://purl.org/obo/owl/PubMed#PubMed_9560161
PubMed:11752597
http://purl.org/obo/owl/PubMed#PubMed_11752597
IMR:0001504
http://purl.org/obo/owl/IMR#IMR_0001504
IMR:0000675
http://purl.org/obo/owl/IMR#IMR_0000675
Binding of Rap1 and Crk
event
PubMed:9560161
http://purl.org/obo/owl/PubMed#PubMed_9560161
GDP-GTP exchange of Rap1 by Epac1 in cytosol
event
PubMed:11752597
http://purl.org/obo/owl/PubMed#PubMed_11752597
IMR:0001504
http://purl.org/obo/owl/IMR#IMR_0001504
IMR:0001968
http://purl.org/obo/owl/IMR#IMR_0001968
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Raf activation signaling
event
Activation of Epac by cAMP in cytosol
event
IMR:0100024
http://purl.org/obo/owl/IMR#IMR_0100024
IMR:0001967
http://purl.org/obo/owl/IMR#IMR_0001967
PubMed:9853756
http://purl.org/obo/owl/PubMed#PubMed_9853756
Binding of G alpha-GDP and effector in cytosol
event
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0000316
http://purl.org/obo/owl/IMR#IMR_0000316
Binding of G alpha o -GDP and Rap1GAP1 in cytosol
event
IMR:0000320
http://purl.org/obo/owl/IMR#IMR_0000320
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
PubMed:10419452
http://purl.org/obo/owl/PubMed#PubMed_10419452
UniProt:P47736
http://purl.org/obo/owl/UniProt#UniProt_P47736
Binding of G alpha i-GTP and Rap1GAP2 in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000319
http://purl.org/obo/owl/IMR#IMR_0000319
UniProt:Q684P5
http://purl.org/obo/owl/UniProt#UniProt_Q684P5
PubMed:10476970
http://purl.org/obo/owl/PubMed#PubMed_10476970
Binding of G alpha z-GTP and effector in cytosol
event
IMR:0000322
http://purl.org/obo/owl/IMR#IMR_0000322
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Binding of G alpha z-GTP and Rap1GAP1 in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000322
http://purl.org/obo/owl/IMR#IMR_0000322
UniProt:P47736
http://purl.org/obo/owl/UniProt#UniProt_P47736
PubMed:10593970
http://purl.org/obo/owl/PubMed#PubMed_10593970
Rap1 activation signaling
event
Rap1 activation signaling (through cAMP and Epac)
event
PubMed:11752597
http://purl.org/obo/owl/PubMed#PubMed_11752597
Rap1 activation signaling (through cAMP, PKA, Cbl and C3G)
event
PubMed:11804588
http://purl.org/obo/owl/PubMed#PubMed_11804588
Phosphorylation of Src by PKA in cytosol
event
PubMed:11804588
http://purl.org/obo/owl/PubMed#PubMed_11804588
IMR:0100575
http://purl.org/obo/owl/IMR#IMR_0100575
IMR:0000249
http://purl.org/obo/owl/IMR#IMR_0000249
Phosphorylation of Cbl by Src in cytosol
event
PubMed:15345216
http://purl.org/obo/owl/PubMed#PubMed_15345216
PubMed:11804588
http://purl.org/obo/owl/PubMed#PubMed_11804588
IMR:0100575
http://purl.org/obo/owl/IMR#IMR_0100575
IMR:0000356
http://purl.org/obo/owl/IMR#IMR_0000356
PubMed:20584982
http://purl.org/obo/owl/PubMed#PubMed_20584982
B-Raf activation signaling
event
Negative regulation of (GDP-GTP exchange of Rap1 by Epac1)
event
IMR:0001968
http://purl.org/obo/owl/IMR#IMR_0001968
IMR:0001504
http://purl.org/obo/owl/IMR#IMR_0001504
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
Phosphorylation of MAPKKK by non-receptor serine/threonine kinase in cytosol
event
IMR:0000229
http://purl.org/obo/owl/IMR#IMR_0000229
IMR:0000681
http://purl.org/obo/owl/IMR#IMR_0000681
Phosphorylation of Raf by PKC in cytosol
event
PubMed:8321321
http://purl.org/obo/owl/PubMed#PubMed_8321321
IMR:0000245
http://purl.org/obo/owl/IMR#IMR_0000245
IMR:0000231
http://purl.org/obo/owl/IMR#IMR_0000231
Phosphorylation of MEK1/2(MKK1/2) by B-Raf in cytosol
event
IMR:0000261
http://purl.org/obo/owl/IMR#IMR_0000261
PubMed:11752597
http://purl.org/obo/owl/PubMed#PubMed_11752597
IMR:0000675
http://purl.org/obo/owl/IMR#IMR_0000675
Rap1 inactivation signaling
event
Hydrolysis of GTP by RapGAP in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Hydrolysis of GTP by Rap1GAP1 in cytosol
event
UniProt:P47736
http://purl.org/obo/owl/UniProt#UniProt_P47736
PubMed:11752597
http://purl.org/obo/owl/PubMed#PubMed_11752597
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Hydrolysis of GTP by Rap1GAP2 in cytosol
event
PubMed:11752597
http://purl.org/obo/owl/PubMed#PubMed_11752597
UniProt:Q684P5
http://purl.org/obo/owl/UniProt#UniProt_Q684P5
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Binding of Crk and Cbl in cytosol
event
IMR:0000335
http://purl.org/obo/owl/IMR#IMR_0000335
IMR:0000356
http://purl.org/obo/owl/IMR#IMR_0000356
PubMed:11804588
http://purl.org/obo/owl/PubMed#PubMed_11804588
Phosphorylation of JNK by MKK_p in cytosol
event
The initiation of the activity of the inactive enzyme JUN kinase by phosphorylation by a JUN kinase kinase (JNKK).
GO:0007257
http://purl.org/obo/owl/GO#GO_0007257
GO:0007257
http://purl.org/obo/owl/GO#GO_0007257
activation of JNK activity
IMR:0000259
http://purl.org/obo/owl/IMR#IMR_0000259
IMR:0000225
http://purl.org/obo/owl/IMR#IMR_0000225
Dissociation of cytokine receptor and STAT in cytosol
event
PubMed:12039028
http://purl.org/obo/owl/PubMed#PubMed_12039028
IMR:0000095
http://purl.org/obo/owl/IMR#IMR_0000095
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
Binding of AP-1 and responsive element in inner space of nucleus
event
IMR:0000414
http://purl.org/obo/owl/IMR#IMR_0000414
IGS:0000028
http://purl.org/obo/owl/IGS#IGS_0000028
Binding of transcription factor and responsive element in inner space of nucleus
event
Binding of transcription factor and responsive element in inner space of nucleus
IMR:0000368
http://purl.org/obo/owl/IMR#IMR_0000368
IGS:0000028
http://purl.org/obo/owl/IGS#IGS_0000028
Transcription of cytokine by AP-1 in nucleus
event
IMR:0000006
http://purl.org/obo/owl/IMR#IMR_0000006
IMR:0000414
http://purl.org/obo/owl/IMR#IMR_0000414
Binding of STAT dimer and GAS in inner space of nucleus
event
IGS:0000018
http://purl.org/obo/owl/IGS#IGS_0000018
PubMed:12039028
http://purl.org/obo/owl/PubMed#PubMed_12039028
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
Gene expression of SOCS by STAT dimer
event
IEV:0000144
IEV:0002234
Gene expression of CIS family
Gene expression of CIS by STAT dimer
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
IMR:0000460
http://purl.org/obo/owl/IMR#IMR_0000460
PubMed:14607831
http://purl.org/obo/owl/PubMed#PubMed_14607831
Gene expression by STAT dimer
event
PubMed:14607831
http://purl.org/obo/owl/PubMed#PubMed_14607831
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
Transcription of SOCS by STAT dimer in nucleus
event
IEV:0002237
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
Transcription of CIS by STAT dimer in nucleus
PubMed:14607831
http://purl.org/obo/owl/PubMed#PubMed_14607831
IMR:0000460
http://purl.org/obo/owl/IMR#IMR_0000460
Translation of SOCS in cytosol
IEV:0002236
event
IMR:0000460
http://purl.org/obo/owl/IMR#IMR_0000460
PubMed:14607831
http://purl.org/obo/owl/PubMed#PubMed_14607831
Translation of CIS in cytosol
Nuclear export of mRNA (SOCS)
event
IEV:0002235
Nuclear export of mRNA (CIS)
PubMed:14607831
http://purl.org/obo/owl/PubMed#PubMed_14607831
IMR:0000460
http://purl.org/obo/owl/IMR#IMR_0000460
Phosphorylation of p38 by MKK_p in cytosol
event
IMR:0000259
http://purl.org/obo/owl/IMR#IMR_0000259
IMR:0000226
http://purl.org/obo/owl/IMR#IMR_0000226
Binding of IFN alpha receptor and STAT2 in cytosol
event
IMR:0000376
http://purl.org/obo/owl/IMR#IMR_0000376
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
IMR:0000135
http://purl.org/obo/owl/IMR#IMR_0000135
Binding of IFN alpha receptor and STAT1 in cytosol
event
PubMed:15561601
http://purl.org/obo/owl/PubMed#PubMed_15561601
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
IMR:0000135
http://purl.org/obo/owl/IMR#IMR_0000135
Binding of IFN alpha receptor and STAT3 in cytosol
event
IMR:0000135
http://purl.org/obo/owl/IMR#IMR_0000135
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
PubMed:15561601
http://purl.org/obo/owl/PubMed#PubMed_15561601
Binding of IFN gamma receptor and STAT1 in cytosol
event
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
IMR:0000136
http://purl.org/obo/owl/IMR#IMR_0000136
Binding of IL-6 receptor and STAT3 in cytosol
event
IMR:0000104
http://purl.org/obo/owl/IMR#IMR_0000104
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
Binding of IL-10 receptor and STAT3 in cytosol
event
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
IMR:0000608
http://purl.org/obo/owl/IMR#IMR_0000608
PubMed:12626585
http://purl.org/obo/owl/PubMed#PubMed_12626585
PubMed:10433356
http://purl.org/obo/owl/PubMed#PubMed_10433356
Binding of IL-2 receptor and STAT5 in cytosol
event
PubMed:10920190
http://purl.org/obo/owl/PubMed#PubMed_10920190
PubMed:11160217
http://purl.org/obo/owl/PubMed#PubMed_11160217
IMR:0000097
http://purl.org/obo/owl/IMR#IMR_0000097
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
Binding of IL-12 receptor and STAT4 in cytosol
event
PubMed:10415122
http://purl.org/obo/owl/PubMed#PubMed_10415122
IMR:0000602
http://purl.org/obo/owl/IMR#IMR_0000602
PubMed:12805384
http://purl.org/obo/owl/PubMed#PubMed_12805384
IMR:0000378
http://purl.org/obo/owl/IMR#IMR_0000378
Nuclear import of ISGF3
event
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
IMR:0001422
http://purl.org/obo/owl/IMR#IMR_0001422
Nuclear import of STAT1:STAT2:IRF9
Nuclear import of STAT1 homodimer
event
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
Nuclear import of STAT3 homodimer
event
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
PubMed:10857556
http://purl.org/obo/owl/PubMed#PubMed_10857556
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
Nuclear import of STAT1:STAT3 heterodimer
event
PubMed:15561601
http://purl.org/obo/owl/PubMed#PubMed_15561601
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
Nuclear import of STAT5 homodimer
event
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
PubMed:15561601
http://purl.org/obo/owl/PubMed#PubMed_15561601
PubMed:11160217
http://purl.org/obo/owl/PubMed#PubMed_11160217
Nuclear import of STAT4 homodimer
event
PubMed:15004198
http://purl.org/obo/owl/PubMed#PubMed_15004198
PubMed:12805384
http://purl.org/obo/owl/PubMed#PubMed_12805384
IMR:0000378
http://purl.org/obo/owl/IMR#IMR_0000378
Dimerization of STAT1 and STAT2 in cytosol
event
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
IMR:0000376
http://purl.org/obo/owl/IMR#IMR_0000376
PubMed:11932384
http://purl.org/obo/owl/PubMed#PubMed_11932384
Dimerization of STAT1 in cytosol
event
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
PubMed:15561601
http://purl.org/obo/owl/PubMed#PubMed_15561601
Dimerization of STAT3 in cytosol
event
PubMed:10857556
http://purl.org/obo/owl/PubMed#PubMed_10857556
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
PubMed:10433356
http://purl.org/obo/owl/PubMed#PubMed_10433356
Dimerization of STAT1 and STAT3 in cytosol
event
PubMed:15561601
http://purl.org/obo/owl/PubMed#PubMed_15561601
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
Dimerization of STAT5 in cytosol
event
PubMed:11160217
http://purl.org/obo/owl/PubMed#PubMed_11160217
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
Dimerization of STAT4 in cytosol
event
IMR:0000378
http://purl.org/obo/owl/IMR#IMR_0000378
PubMed:15004198
http://purl.org/obo/owl/PubMed#PubMed_15004198
Phosphorylation of STAT2 by JAK1_p and TYK2_p in cytosol
event
IMR:0000376
http://purl.org/obo/owl/IMR#IMR_0000376
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0100322
http://purl.org/obo/owl/IMR#IMR_0100322
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
Phosphorylation of STAT1 by JAK1_p and TYK2_p in cytosol
event
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
IMR:0100322
http://purl.org/obo/owl/IMR#IMR_0100322
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
PubMed:15561601
http://purl.org/obo/owl/PubMed#PubMed_15561601
Phosphorylation of STAT3 by JAK1_p and TYK2_p in cytosol
event
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
IMR:0100322
http://purl.org/obo/owl/IMR#IMR_0100322
PubMed:10433356
http://purl.org/obo/owl/PubMed#PubMed_10433356
PubMed:12626585
http://purl.org/obo/owl/PubMed#PubMed_12626585
PubMed:15561601
http://purl.org/obo/owl/PubMed#PubMed_15561601
Phosphorylation of STAT3 by JAK1_p and JAK2_p in cytosol
event
PubMed:10857556
http://purl.org/obo/owl/PubMed#PubMed_10857556
PubMed:15504351
http://purl.org/obo/owl/PubMed#PubMed_15504351
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
Phosphorylation of STAT5 by JAK1_p and JAK3_p in cytosol
event
IMR:0100321
http://purl.org/obo/owl/IMR#IMR_0100321
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
PubMed:111278301
http://purl.org/obo/owl/PubMed#PubMed_111278301
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
Phosphorylation of STAT4 by JAK2_p and TYK2_p in cytosol
event
PubMed:10415122
http://purl.org/obo/owl/PubMed#PubMed_10415122
PubMed:12805384
http://purl.org/obo/owl/PubMed#PubMed_12805384
IMR:0000378
http://purl.org/obo/owl/IMR#IMR_0000378
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
IMR:0100322
http://purl.org/obo/owl/IMR#IMR_0100322
Binding of GAF and GAS element in inner space of nucleus
event
Binding of STAT1 homodimer and GAS element
IGS:0000018
http://purl.org/obo/owl/IGS#IGS_0000018
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
Binding of STAT3 homodimer and GAS element in inner space of nucleus
event
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
PubMed:10857556
http://purl.org/obo/owl/PubMed#PubMed_10857556
IGS:0000018
http://purl.org/obo/owl/IGS#IGS_0000018
Binding of STAT3 homodimer and SIE element in inner space of nucleus
event
IGS:0000019
http://purl.org/obo/owl/IGS#IGS_0000019
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
PubMed:10857556
http://purl.org/obo/owl/PubMed#PubMed_10857556
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
Binding of STAT1:STAT3 heterodimer and responsive element in inner space of nucleus
event
IGS:0000028
http://purl.org/obo/owl/IGS#IGS_0000028
PubMed:15561601
http://purl.org/obo/owl/PubMed#PubMed_15561601
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
Binding of STAT5 homodimer and GAS element in inner space of nucleus
event
IGS:0000018
http://purl.org/obo/owl/IGS#IGS_0000018
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
PubMed:15561601
http://purl.org/obo/owl/PubMed#PubMed_15561601
Binding of ISGF3 and ISRE in inner space of nucleus
event
IGS:0000021
http://purl.org/obo/owl/IGS#IGS_0000021
Binding of STAT1:STAT2:IRF9 and ISRE
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
IMR:0001422
http://purl.org/obo/owl/IMR#IMR_0001422
Binding of STAT4 homodimer and GAS element in inner space of nucleus
event
IGS:0000018
http://purl.org/obo/owl/IGS#IGS_0000018
PubMed:15004198
http://purl.org/obo/owl/PubMed#PubMed_15004198
IMR:0000378
http://purl.org/obo/owl/IMR#IMR_0000378
PubMed:9144409
http://purl.org/obo/owl/PubMed#PubMed_9144409
Phosphorylation of IFN alpha receptor by JAK1 and TYK2 in cytosol
event
IMR:0100322
http://purl.org/obo/owl/IMR#IMR_0100322
IMR:0000135
http://purl.org/obo/owl/IMR#IMR_0000135
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
PubMed:15561601
http://purl.org/obo/owl/PubMed#PubMed_15561601
PubMed:9287210
http://purl.org/obo/owl/PubMed#PubMed_9287210
Phosphorylation of IFN gamma receptor by JAK1 and JAK2 in cytosol
event
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0000136
http://purl.org/obo/owl/IMR#IMR_0000136
Phosphorylation of IL-6 receptor by JAK1 and JAK2 in cytosol
event
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
PubMed:15504351
http://purl.org/obo/owl/PubMed#PubMed_15504351
IMR:0000104
http://purl.org/obo/owl/IMR#IMR_0000104
Phosphorylation of IL-10 receptor by JAK1 and TYK2 in cytosol
event
PubMed:12626585
http://purl.org/obo/owl/PubMed#PubMed_12626585
IMR:0000608
http://purl.org/obo/owl/IMR#IMR_0000608
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0100322
http://purl.org/obo/owl/IMR#IMR_0100322
Phosphorylation of IL-2 receptor by JAK1 and JAK3 in cytosol
event
PubMed:11160217
http://purl.org/obo/owl/PubMed#PubMed_11160217
IMR:0000097
http://purl.org/obo/owl/IMR#IMR_0000097
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0100321
http://purl.org/obo/owl/IMR#IMR_0100321
PubMed:10920190
http://purl.org/obo/owl/PubMed#PubMed_10920190
Phosphorylation of IL-12 receptor by JAK2 and TYK2 in cytosol
event
PubMed:10415122
http://purl.org/obo/owl/PubMed#PubMed_10415122
IMR:0100322
http://purl.org/obo/owl/IMR#IMR_0100322
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
IMR:0000602
http://purl.org/obo/owl/IMR#IMR_0000602
PubMed:12805384
http://purl.org/obo/owl/PubMed#PubMed_12805384
Binding of IFN alpha receptor and JAK1 and TYK2 in cytosol
event
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0100322
http://purl.org/obo/owl/IMR#IMR_0100322
IMR:0000135
http://purl.org/obo/owl/IMR#IMR_0000135
Binding of IFN gamma receptor and JAK1 and JAK2 in cytosol
event
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0000136
http://purl.org/obo/owl/IMR#IMR_0000136
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
Binding of IL-6 receptor and JAK1 and JAK2 in cytosol
event
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
IMR:0000104
http://purl.org/obo/owl/IMR#IMR_0000104
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
Binding of IL-10 receptor and JAK1 and TYK2 in cytosol
event
PubMed:12626585
http://purl.org/obo/owl/PubMed#PubMed_12626585
IMR:0000608
http://purl.org/obo/owl/IMR#IMR_0000608
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0100322
http://purl.org/obo/owl/IMR#IMR_0100322
Binding of IL-2 receptor and JAK1 and JAK3 in cytosol
event
IMR:0100321
http://purl.org/obo/owl/IMR#IMR_0100321
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0000097
http://purl.org/obo/owl/IMR#IMR_0000097
PubMed:8700888
http://purl.org/obo/owl/PubMed#PubMed_8700888
PubMed:10920190
http://purl.org/obo/owl/PubMed#PubMed_10920190
Binding of IL-12 receptor and JAK2 and TYK2 in cytosol
event
PubMed:12805384
http://purl.org/obo/owl/PubMed#PubMed_12805384
IMR:0100322
http://purl.org/obo/owl/IMR#IMR_0100322
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
IMR:0000602
http://purl.org/obo/owl/IMR#IMR_0000602
Binding of IFN alpha and IFN alpha receptor and conformational change of receptors in plasma membrane
event
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
IMR:0000135
http://purl.org/obo/owl/IMR#IMR_0000135
IMR:0100386
http://purl.org/obo/owl/IMR#IMR_0100386
Binding of IFN gamma and IFN gamma receptor and conformational change of receptors in plasma membrane
event
IMR:0000136
http://purl.org/obo/owl/IMR#IMR_0000136
IMR:0100390
http://purl.org/obo/owl/IMR#IMR_0100390
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
Binding of IL-6 and IL-6 receptor and conformational change of receptors in plasma membrane
event
IMR:0000010
http://purl.org/obo/owl/IMR#IMR_0000010
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
IMR:0000104
http://purl.org/obo/owl/IMR#IMR_0000104
Binding of LIF receptor and STAT3 in cytosol
event
PubMed:10857556
http://purl.org/obo/owl/PubMed#PubMed_10857556
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
IMR:0000130
http://purl.org/obo/owl/IMR#IMR_0000130
Phosphorylation of LIF receptor by JAK1 and JAK2 in cytosol
event
PubMed:10857556
http://purl.org/obo/owl/PubMed#PubMed_10857556
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0000130
http://purl.org/obo/owl/IMR#IMR_0000130
Binding of LIF receptor and JAK1 and JAK2 in cytosol
event
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
PubMed:10586060
http://purl.org/obo/owl/PubMed#PubMed_10586060
PubMed:10857556
http://purl.org/obo/owl/PubMed#PubMed_10857556
IMR:0000130
http://purl.org/obo/owl/IMR#IMR_0000130
Autophosphorylation of TYK2 in cytosol
event
PubMed:9287210
http://purl.org/obo/owl/PubMed#PubMed_9287210
IMR:0100322
http://purl.org/obo/owl/IMR#IMR_0100322
PubMed:12626585
http://purl.org/obo/owl/PubMed#PubMed_12626585
PubMed:15561601
http://purl.org/obo/owl/PubMed#PubMed_15561601
PubMed:10433356
http://purl.org/obo/owl/PubMed#PubMed_10433356
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
Autophosphorylation of JAK2 in cytosol
event
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
PubMed:10857556
http://purl.org/obo/owl/PubMed#PubMed_10857556
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
PubMed:9287210
http://purl.org/obo/owl/PubMed#PubMed_9287210
PubMed:15561601
http://purl.org/obo/owl/PubMed#PubMed_15561601
PubMed:9351438
http://purl.org/obo/owl/PubMed#PubMed_9351438
The process of introducing a phosphoric group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it.
GO:0042977
http://purl.org/obo/owl/GO#GO_0042977
Autophosphorylation of JAK1 in cytosol
event
PubMed:12039028
http://purl.org/obo/owl/PubMed#PubMed_12039028
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
PubMed:10857556
http://purl.org/obo/owl/PubMed#PubMed_10857556
PubMed:10920190
http://purl.org/obo/owl/PubMed#PubMed_10920190
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
PubMed:10433356
http://purl.org/obo/owl/PubMed#PubMed_10433356
PubMed:15561601
http://purl.org/obo/owl/PubMed#PubMed_15561601
PubMed:9287210
http://purl.org/obo/owl/PubMed#PubMed_9287210
PubMed:9351438
http://purl.org/obo/owl/PubMed#PubMed_9351438
Autophosphorylation of JAK3 in cytosol
event
IMR:0100321
http://purl.org/obo/owl/IMR#IMR_0100321
PubMed:10920190
http://purl.org/obo/owl/PubMed#PubMed_10920190
PubMed:11160217
http://purl.org/obo/owl/PubMed#PubMed_11160217
PubMed:9287210
http://purl.org/obo/owl/PubMed#PubMed_9287210
PubMed:12039028
http://purl.org/obo/owl/PubMed#PubMed_12039028
Dissociation of IFN alpha receptor and STAT1 in cytosol
event
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
IMR:0000135
http://purl.org/obo/owl/IMR#IMR_0000135
PubMed:15561601
http://purl.org/obo/owl/PubMed#PubMed_15561601
Dissociation of IFN alpha receptor and STAT3 in cytosol
event
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
PubMed:15561601
http://purl.org/obo/owl/PubMed#PubMed_15561601
IMR:0000135
http://purl.org/obo/owl/IMR#IMR_0000135
Dissociation of IFN gamma receptor and STAT1 in cytosol
event
IMR:0000136
http://purl.org/obo/owl/IMR#IMR_0000136
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
Dissociation of IL-6 receptor and STAT3 in cytosol
event
IMR:0000104
http://purl.org/obo/owl/IMR#IMR_0000104
PubMed:15504351
http://purl.org/obo/owl/PubMed#PubMed_15504351
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
Dissociation of IL-10 receptor and STAT3 in cytosol
event
PubMed:15561601
http://purl.org/obo/owl/PubMed#PubMed_15561601
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
IMR:0000608
http://purl.org/obo/owl/IMR#IMR_0000608
Dissociation of IL-2 receptor and STAT5 in cytosol
event
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
IMR:0000097
http://purl.org/obo/owl/IMR#IMR_0000097
PubMed:12039028
http://purl.org/obo/owl/PubMed#PubMed_12039028
PubMed:11160217
http://purl.org/obo/owl/PubMed#PubMed_11160217
Dissociation of IL-12 receptor and STAT4 in cytosol
event
IMR:0000378
http://purl.org/obo/owl/IMR#IMR_0000378
IMR:0000602
http://purl.org/obo/owl/IMR#IMR_0000602
PubMed:15004198
http://purl.org/obo/owl/PubMed#PubMed_15004198
PubMed:12039028
http://purl.org/obo/owl/PubMed#PubMed_12039028
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
Binding of STAT1 and STAT2_p in cytosol
event
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
IMR:0000376
http://purl.org/obo/owl/IMR#IMR_0000376
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
Binding of STAT1:STAT2 heterodimer and IRF9 in cytosol
event
PubMed:11932384
http://purl.org/obo/owl/PubMed#PubMed_11932384
IMR:0000395
http://purl.org/obo/owl/IMR#IMR_0000395
IMR:0000376
http://purl.org/obo/owl/IMR#IMR_0000376
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
Binding of LIF and LIF receptor and conformational change of receptors in plasma membrane
event
PubMed:12487370
http://purl.org/obo/owl/PubMed#PubMed_12487370
PubMed:10857556
http://purl.org/obo/owl/PubMed#PubMed_10857556
IMR:0000130
http://purl.org/obo/owl/IMR#IMR_0000130
IMR:0000019
http://purl.org/obo/owl/IMR#IMR_0000019
Binding of BMP2 and BMP receptor I/II in extracellular
event
IMR:0001425
http://purl.org/obo/owl/IMR#IMR_0001425
IMR:0001424
http://purl.org/obo/owl/IMR#IMR_0001424
IMR:0000702
http://purl.org/obo/owl/IMR#IMR_0000702
Nuclear import of Smad1:Smad4
event
IMR:0100310
http://purl.org/obo/owl/IMR#IMR_0100310
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
Complex formation of Smad1 and Smad4 in cytosol
event
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
IMR:0100310
http://purl.org/obo/owl/IMR#IMR_0100310
Binding of STAT3:p300:Smad1:Smad4 complex and GFAP promoter in inner space of nucleus
event
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
IMR:0100310
http://purl.org/obo/owl/IMR#IMR_0100310
IMR:0001405
http://purl.org/obo/owl/IMR#IMR_0001405
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
UniProt:P14136
http://purl.org/obo/owl/UniProt#UniProt_P14136
Dissociation of LIF receptor and STAT3 in cytosol
event
IMR:0000130
http://purl.org/obo/owl/IMR#IMR_0000130
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
PubMed:10857556
http://purl.org/obo/owl/PubMed#PubMed_10857556
Phosphorylation of BMPR1 by BMPR2 in cytosol
event
IMR:0001425
http://purl.org/obo/owl/IMR#IMR_0001425
IMR:0000702
http://purl.org/obo/owl/IMR#IMR_0000702
Binding of STAT3 and p300 and Smad1 in inner space of nucleus
event
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
IMR:0100310
http://purl.org/obo/owl/IMR#IMR_0100310
IMR:0001405
http://purl.org/obo/owl/IMR#IMR_0001405
Translocation of TRAF6 to cytosol
event
IMR:0100427
http://purl.org/obo/owl/IMR#IMR_0100427
TGF beta receptor complex degradation signaling
event
PubMed:11278251
http://purl.org/obo/owl/PubMed#PubMed_11278251
Complex formation of Smad7 and smurf1 in cytosol
event
PubMed:11278251
http://purl.org/obo/owl/PubMed#PubMed_11278251
IMR:0100513
http://purl.org/obo/owl/IMR#IMR_0100513
IMR:0100318
http://purl.org/obo/owl/IMR#IMR_0100318
Binding of Smad7:smurf1 and TGF beta receptor complex in cytosol
event
IMR:0100513
http://purl.org/obo/owl/IMR#IMR_0100513
PubMed:11278251
http://purl.org/obo/owl/PubMed#PubMed_11278251
IMR:0000092
http://purl.org/obo/owl/IMR#IMR_0000092
IMR:0100318
http://purl.org/obo/owl/IMR#IMR_0100318
Proteasome degradation of TGF beta receptor complex by 26S proteasome in plasma membrane
event
PubMed:11278251
http://purl.org/obo/owl/PubMed#PubMed_11278251
IMR:0000310
http://purl.org/obo/owl/IMR#IMR_0000310
IMR:0000092
http://purl.org/obo/owl/IMR#IMR_0000092
Dissociation of Smad7:smurf1 and TGF beta receptor complex_Ub in cytosol
event
IMR:0100318
http://purl.org/obo/owl/IMR#IMR_0100318
IMR:0000092
http://purl.org/obo/owl/IMR#IMR_0000092
PubMed:11278251
http://purl.org/obo/owl/PubMed#PubMed_11278251
IMR:0100513
http://purl.org/obo/owl/IMR#IMR_0100513
Ubiquitination of TGF beta receptor complex by smurf1 in cytosol
event
PubMed:11278251
http://purl.org/obo/owl/PubMed#PubMed_11278251
IMR:0000092
http://purl.org/obo/owl/IMR#IMR_0000092
IMR:0100513
http://purl.org/obo/owl/IMR#IMR_0100513
Negative regulation of (transcription by R-Smad:Smad4) in TGF beta super family signaling pathway
event
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
Binding of R-Smad:Smad4 complex, Corepressor, HDAC and responsive element in inner space of nucleus
event
IGS:0000028
http://purl.org/obo/owl/IGS#IGS_0000028
IMR:0000427
http://purl.org/obo/owl/IMR#IMR_0000427
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
IMR:0001166
http://purl.org/obo/owl/IMR#IMR_0001166
SnoN degradation signaling
event
PubMed:11389444
http://purl.org/obo/owl/PubMed#PubMed_11389444
Binding of Smad2, smurf2 and SnoN
event
IMR:0100514
http://purl.org/obo/owl/IMR#IMR_0100514
PubMed:11389444
http://purl.org/obo/owl/PubMed#PubMed_11389444
IMR:0002129
http://purl.org/obo/owl/IMR#IMR_0002129
IMR:0100311
http://purl.org/obo/owl/IMR#IMR_0100311
Positive regulation of (transcription by R-Smad:Smad4 ) in TGF beta super family signaling pathway
event
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
Ubiquitination of SnoN by smurf2
event
IMR:0100514
http://purl.org/obo/owl/IMR#IMR_0100514
IMR:0002129
http://purl.org/obo/owl/IMR#IMR_0002129
PubMed:11389444
http://purl.org/obo/owl/PubMed#PubMed_11389444
Proteasome degradation of SnoN_ub by 26S proteasome
event
PubMed:11389444
http://purl.org/obo/owl/PubMed#PubMed_11389444
IMR:0002129
http://purl.org/obo/owl/IMR#IMR_0002129
IMR:0000310
http://purl.org/obo/owl/IMR#IMR_0000310
Phosphorylation of Smad1 by MAPK in cytosol
event
IMR:0100310
http://purl.org/obo/owl/IMR#IMR_0100310
PubMed:11752591
http://purl.org/obo/owl/PubMed#PubMed_11752591
IMR:0000224
http://purl.org/obo/owl/IMR#IMR_0000224
Binding of LAT and Grb2 in cytosol
event
PubMed:15220003
http://purl.org/obo/owl/PubMed#PubMed_15220003
IMR:0000340
http://purl.org/obo/owl/IMR#IMR_0000340
IMR:0000348
http://purl.org/obo/owl/IMR#IMR_0000348
Binding of RasGRP and DAG in cytosol
event
IMR:0100349
http://purl.org/obo/owl/IMR#IMR_0100349
PubMed:15221855
http://purl.org/obo/owl/PubMed#PubMed_15221855
IMR:0100027
http://purl.org/obo/owl/IMR#IMR_0100027
Regulation of CD4 T cell receptor signaling (through Ras Vav, Rac and JNK cascade)
event
Regulation of CD4 T cell receptor signaling pathway (through Ras Vav, Rac and JNK cascade)
Negative regulation of CD4 T cell receptor signaling (through Ras Vav, Rac and JNK cascade)
event
Negative regulation of CD4 T cell receptor signaling pathway (through Ras Vav, Rac and JNK cascade)
Raf activation signaling (through RasGRP)
event
GDP-GTP exchange of Ras by RasGRP in cytosol
event
PubMed:15221855
http://purl.org/obo/owl/PubMed#PubMed_15221855
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0100349
http://purl.org/obo/owl/IMR#IMR_0100349
IMR:0000290
http://purl.org/obo/owl/IMR#IMR_0000290
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Positive regulation of CD4 T cell receptor signaling (through Ras Vav, Rac and JNK cascade)
event
Positive regulation of CD4 T cell receptor signaling pathway (through Ras Vav, Rac and JNK cascade)
Activation of PKC theta by Rac in cytosol
event
PubMed:11094261
http://purl.org/obo/owl/PubMed#PubMed_11094261
IMR:0100484
http://purl.org/obo/owl/IMR#IMR_0100484
IMR:0000297
http://purl.org/obo/owl/IMR#IMR_0000297
Phosphorylation of MKK4(SEK1) by PKC theta in cytosol
event
PubMed:11094621
http://purl.org/obo/owl/PubMed#PubMed_11094621
IMR:0100454
http://purl.org/obo/owl/IMR#IMR_0100454
IMR:0100484
http://purl.org/obo/owl/IMR#IMR_0100484
Phosphorylation of JNK by MKK4(SEK1)_p in cytosol
event
IMR:0000225
http://purl.org/obo/owl/IMR#IMR_0000225
IMR:0100454
http://purl.org/obo/owl/IMR#IMR_0100454
PubMed:11094261
http://purl.org/obo/owl/PubMed#PubMed_11094261
Nuclear transport of AP-1
event
PubMed:7546397
http://purl.org/obo/owl/PubMed#PubMed_7546397
IMR:0000414
http://purl.org/obo/owl/IMR#IMR_0000414
Gene expression of IL2 by AP-1
event
IMR:0000008
http://purl.org/obo/owl/IMR#IMR_0000008
PubMed:7546397
http://purl.org/obo/owl/PubMed#PubMed_7546397
IMR:0000414
http://purl.org/obo/owl/IMR#IMR_0000414
Nuclear export of mRNA (IL2)
event
IMR:0000008
http://purl.org/obo/owl/IMR#IMR_0000008
Transcription of IL2 by AP-1 in nucleus
event
PubMed:7546397
http://purl.org/obo/owl/PubMed#PubMed_7546397
IMR:0000008
http://purl.org/obo/owl/IMR#IMR_0000008
IMR:0000414
http://purl.org/obo/owl/IMR#IMR_0000414
Translation of IL2 in cytosol
event
IMR:0000008
http://purl.org/obo/owl/IMR#IMR_0000008
PubMed:7546397
http://purl.org/obo/owl/PubMed#PubMed_7546397
Nuclear export of mRNA (cytokine)
event
IMR:0000006
http://purl.org/obo/owl/IMR#IMR_0000006
Translation of cytokine in cytosol
event
IMR:0000006
http://purl.org/obo/owl/IMR#IMR_0000006
Chilling temperature treatment
event
Thermoperiodism
event
Cell division within the secondary xylem
event
Cell division within the vascular cambium
event
Cell wall organization and biosynthesis
event
Cellulose biosynthesis
event
The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.
GO:0030244
http://purl.org/obo/owl/GO#GO_0030244
GO:0030244
http://purl.org/obo/owl/GO#GO_0030244
cellulose anabolism
cellulose biosynthetic process
cellulose formation
cellulose synthesis
Hemicellulose biosynthesis
event
Cytokine receptor degradation signaling
event
PubMed:15541651
http://purl.org/obo/owl/PubMed#PubMed_15541651
Ubiquitination of cytokine receptor by SOCS3 in cytosol
event
IMR:0000095
http://purl.org/obo/owl/IMR#IMR_0000095
IMR:0100839
http://purl.org/obo/owl/IMR#IMR_0100839
PubMed:15541651
http://purl.org/obo/owl/PubMed#PubMed_15541651
Binding of SOCS3 and cytokine receptor in cytosol
event
PubMed:15541651
http://purl.org/obo/owl/PubMed#PubMed_15541651
IMR:0000095
http://purl.org/obo/owl/IMR#IMR_0000095
IMR:0100839
http://purl.org/obo/owl/IMR#IMR_0100839
PubMed:14607831
http://purl.org/obo/owl/PubMed#PubMed_14607831
Proteasome degradation of cytokine receptor by 26S proteasome in cytosol
event
IMR:0000310
http://purl.org/obo/owl/IMR#IMR_0000310
PubMed:15541651
http://purl.org/obo/owl/PubMed#PubMed_15541651
IMR:0000095
http://purl.org/obo/owl/IMR#IMR_0000095
Negative feedback regulation of JAK STAT pathway by (cytokine receptor degradation signaling)
event
Gene expression of SOCS3 by STAT dimer
event
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
IMR:0100839
http://purl.org/obo/owl/IMR#IMR_0100839
Transcription of SOCS3 by STAT dimer in nucleus
event
PubMed:14607831
http://purl.org/obo/owl/PubMed#PubMed_14607831
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
IMR:0100839
http://purl.org/obo/owl/IMR#IMR_0100839
Nuclear export of mRNA (SOCS3)
event
IMR:0100839
http://purl.org/obo/owl/IMR#IMR_0100839
PubMed:14607831
http://purl.org/obo/owl/PubMed#PubMed_14607831
Translation of SOCS3 in cytosol
event
PubMed:14607831
http://purl.org/obo/owl/PubMed#PubMed_14607831
IMR:0100839
http://purl.org/obo/owl/IMR#IMR_0100839
Negative feedback regulation of JAK STAT pathway
event
Negative feedback regulation of JAK STAT pathway by (JAK degradation signaling)
event
JAK degradation signaling
event
Binding of SOCS1 and JAK in cytosol
event
IMR:0000213
http://purl.org/obo/owl/IMR#IMR_0000213
IMR:0100837
http://purl.org/obo/owl/IMR#IMR_0100837
Ubiquitination of JAK by SOCS1
event
IMR:0100837
http://purl.org/obo/owl/IMR#IMR_0100837
IMR:0000213
http://purl.org/obo/owl/IMR#IMR_0000213
Proteasome degradation of JAK by 26S proteasome
event
IMR:0000213
http://purl.org/obo/owl/IMR#IMR_0000213
IMR:0000310
http://purl.org/obo/owl/IMR#IMR_0000310
Gene expression of SOCS1 by STAT dimer
event
IMR:0100837
http://purl.org/obo/owl/IMR#IMR_0100837
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
PubMed:14607831
http://purl.org/obo/owl/PubMed#PubMed_14607831
Nuclear export of mRNA (SOCS1)
event
IMR:0100837
http://purl.org/obo/owl/IMR#IMR_0100837
PubMed:14607831
http://purl.org/obo/owl/PubMed#PubMed_14607831
Transcription of SOCS1 by STAT dimer in nucleus
event
PubMed:14607831
http://purl.org/obo/owl/PubMed#PubMed_14607831
IMR:0100837
http://purl.org/obo/owl/IMR#IMR_0100837
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
Translation of SOCS1 in cytosol
event
PubMed:14607831
http://purl.org/obo/owl/PubMed#PubMed_14607831
IMR:0100837
http://purl.org/obo/owl/IMR#IMR_0100837
Dephosphorylation of JAK by SHP-1 in cytosol
event
IMR:0000275
http://purl.org/obo/owl/IMR#IMR_0000275
PubMed:14607831
http://purl.org/obo/owl/PubMed#PubMed_14607831
IMR:0000213
http://purl.org/obo/owl/IMR#IMR_0000213
Dephosphorylation of cytokine receptor by SHP-1 in cytosol
event
IMR:0000275
http://purl.org/obo/owl/IMR#IMR_0000275
IMR:0000095
http://purl.org/obo/owl/IMR#IMR_0000095
Dephosphorylation of STAT5 by SHP-1 in cytosol
event
PubMed:10617656
http://purl.org/obo/owl/PubMed#PubMed_10617656
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
IMR:0000275
http://purl.org/obo/owl/IMR#IMR_0000275
Negative regulation of (Dimerization of STAT) in JAK STAT pathway
event
PubMed:10617656
http://purl.org/obo/owl/PubMed#PubMed_10617656
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway
event
IMR:0000460
http://purl.org/obo/owl/IMR#IMR_0000460
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
Phosphorylation of STAT dimer by serine kinase in cytosol and/or nucleus
event
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
PubMed:9153303
http://purl.org/obo/owl/PubMed#PubMed_9153303
IMR:0000223
http://purl.org/obo/owl/IMR#IMR_0000223
Regulation of CD4 T cell receptor signaling (through Ras and Erk cascade)
event
Regulation of CD4 T cell receptor signaling pathway (through Ras and Erk cascade)
Negative regulation of CD4 T cell receptor signaling (through Ras and Erk cascade)
event
Negative regulation of CD4 T cell receptor signaling pathway (through Ras and Erk cascade)
Positive regulation of CD4 T cell receptor signaling (through Ras and Erk cascade)
event
Positive regulation of CD4 T cell receptor signaling pathway (through Ras and Erk cascade)
Negative regulation of (Phosphorylation of ZAP-70 by Lck_PY)
event
IMR:0100353
http://purl.org/obo/owl/IMR#IMR_0100353
IMR:0000221
http://purl.org/obo/owl/IMR#IMR_0000221
Negative regulation of (Phosphorylation of PIP2 by PI3K)
event
IMR:0000265
http://purl.org/obo/owl/IMR#IMR_0000265
IMR:0001350
http://purl.org/obo/owl/IMR#IMR_0001350
Negative regulation of (Phosphorylation of LAT by ZAP-70)
event
IMR:0000221
http://purl.org/obo/owl/IMR#IMR_0000221
Negative regulation of (Phosphorylation of Vav by ZAP-70)
event
IMR:0000221
http://purl.org/obo/owl/IMR#IMR_0000221
Negative regulation of (Lck activation signaling)
event
Negative regulation of (Fyn activation signaling)
event
Negative regulation of (Phosphorylation of Vav by Syk)
event
IMR:0000222
http://purl.org/obo/owl/IMR#IMR_0000222
Actin filament reorganization during cell cycle
event
Rearrangement of the spatial distribution of actin filaments and associated proteins that accompanies progression of the cell cycle.
GO:0030037
http://purl.org/obo/owl/GO#GO_0030037
PubMed:15313367
http://purl.org/obo/owl/PubMed#PubMed_15313367
GO:0030037
http://purl.org/obo/owl/GO#GO_0030037
IL6 signaling pathway (JAK1, JAK2, STAT3)
event
PubMed:12773095
http://purl.org/obo/owl/PubMed#PubMed_12773095
IFN alpha signaling pathway (JAK1, TYK2, STAT1)
event
PubMed:15561601
http://purl.org/obo/owl/PubMed#PubMed_15561601
IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT3)
event
PubMed:15561601
http://purl.org/obo/owl/PubMed#PubMed_15561601
LIF signaling pathway
event
The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands.
GO:0048861
http://purl.org/obo/owl/GO#GO_0048861
GO:0048861
http://purl.org/obo/owl/GO#GO_0048861
PubMed:10857556
http://purl.org/obo/owl/PubMed#PubMed_10857556
leukemia inhibitory factor signaling pathway
IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT2)
event
PubMed:12041185
http://purl.org/obo/owl/PubMed#PubMed_12041185
IFN gamma signaling pathway (JAK1, JAK2, STAT1)
event
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
IFN alpha signaling pathway (JAK1, TYK2, STAT3)
event
PubMed:15561601
http://purl.org/obo/owl/PubMed#PubMed_15561601
TGF beta super family signaling pathway (through JNK cascade)
event
PubMed:15733830
http://purl.org/obo/owl/PubMed#PubMed_15733830
Wnt signaling pathway (Xenopus)
event
OBSOLETE: remap to 'Wnt signaling pathway' IEV:0000027.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
Wnt signaling pathway (Mammalia)
event
OBSOLETE: remap to 'Wnt signaling pathway' IEV:0000027.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
Wnt signaling pathway (Drosophila)
event
OBSOLETE: remap to 'Wnt signaling pathway' IEV:0000027.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
C. elegans endoderm induction Wnt signaling pathway
event
PubMed:12210516
http://purl.org/obo/owl/PubMed#PubMed_12210516
OBSOLETE: remap to 'Endoderm induction Wnt signaling pathway' IEV:0003455.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Phosphorylation of STAT1 by JAK1_p and JAK2_p in cytosol
event
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
PubMed:12040185
http://purl.org/obo/owl/PubMed#PubMed_12040185
Binding of beta-catenin, TCF and Smad4 in inner space of nucleus
event
PubMed:10693808
http://purl.org/obo/owl/PubMed#PubMed_10693808
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
IMR:0000418
http://purl.org/obo/owl/IMR#IMR_0000418
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
PubMed:10890911
http://purl.org/obo/owl/PubMed#PubMed_10890911
Dissociation of Groucho and TCF in inner space of nucleus
event
IMR:0000418
http://purl.org/obo/owl/IMR#IMR_0000418
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
IMR:0100748
http://purl.org/obo/owl/IMR#IMR_0100748
Binding of beta-catenin:TCF:Smad4 and responsive element in inner space of nucleus
event
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
IGS:0000028
http://purl.org/obo/owl/IGS#IGS_0000028
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
IMR:0000418
http://purl.org/obo/owl/IMR#IMR_0000418
PubMed:10890911
http://purl.org/obo/owl/PubMed#PubMed_10890911
PubMed:10693808
http://purl.org/obo/owl/PubMed#PubMed_10693808
Transcription of Xtwn gene in nucleus
event
PubMed:10693808
http://purl.org/obo/owl/PubMed#PubMed_10693808
PubMed:10890911
http://purl.org/obo/owl/PubMed#PubMed_10890911
IMR:0001829
http://purl.org/obo/owl/IMR#IMR_0001829
Transcription of Siamois gene in nucleus
event
IMR:0001830
http://purl.org/obo/owl/IMR#IMR_0001830
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
Binding of Wnt and HSPG in extracellular
event
IMR:0000003
http://purl.org/obo/owl/IMR#IMR_0000003
IMR:0001125
http://purl.org/obo/owl/IMR#IMR_0001125
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
PubMed:2158444
http://purl.org/obo/owl/PubMed#PubMed_2158444
Binding of wingless and Dally in extracellular
event
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
IMR:0002958
http://purl.org/obo/owl/IMR#IMR_0002958
IMR:0100761
http://purl.org/obo/owl/IMR#IMR_0100761
PubMed:10421371
http://purl.org/obo/owl/PubMed#PubMed_10421371
PubMed:10978892
http://purl.org/obo/owl/PubMed#PubMed_10978892
Gene expression by beta-catenin:TCF complex
IEV:0002277
event
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
Gene expression in response to beta-catenin TCF complex
IMR:0000418
http://purl.org/obo/owl/IMR#IMR_0000418
Gene expression by beta-catenin TCF complex
Transcription by beta-catenin:TCF complex in nucleus
event
IEV:0000037
Transcription in response to beta-catenin TCF complex
Transcription in response to beta-catenin TCF complex (Xenopus laevis)
Transcription by beta-catenin TCF complex (C. elegans)
Transcription by beta-catenin TCF complex (Mammals)
Transcription by beta-catenin TCF complex (Drosophila)
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
Transcription by beta-catenin TCF complex (Xenopus)
IMR:0000418
http://purl.org/obo/owl/IMR#IMR_0000418
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
Gene expression by beta-catenin:TCF complex and Smad4
event
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
IMR:0000418
http://purl.org/obo/owl/IMR#IMR_0000418
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
Transcription by beta-catenin:TCF complex and Smad4 in nucleus
event
Transcription by beta-catenin TCF complex and Smad4 (Xenopus)
Transcription by beta-catenin TCF complex and Smad4 (Mammals)
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
IMR:0000418
http://purl.org/obo/owl/IMR#IMR_0000418
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
Transcription by beta-catenin TCF complex and Smad4 (Xenopus)
event
OBSOLETE: remap to 'Transcription by beta-catenin TCF complex and Smad4' IEV:0002284.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Transcription by beta-catenin TCF complex (Mammals)
event
OBSOLETE: remap to 'Transcription by beta-catenin TCF complex' IEV:0002282.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Transcription by beta-catenin TCF complex (Drosophila)
event
PubMed:15473860
http://purl.org/obo/owl/PubMed#PubMed_15473860
OBSOLETE: remap to 'Transcription by beta-catenin TCF complex' IEV:0002282.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Transcription by beta-catenin TCF complex and Smad4 (Mammals)
event
OBSOLETE: remap to 'Transcription by beta-catenin TCF complex and Smad4' IEV:0002284.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Transcription by beta-catenin TCF complex (Xenopus)
event
OBSOLETE: remap to 'Transcription by beta-catenin TCF complex' IEV:0002282.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Regulation of B cell receptor signaling (through IKK-NF-kappaB cascade)
event
Regulation of B cell receptor signaling pathway (through IKK-NF-kappaB cascade)
Negative regulation of B cell receptor signaling (through IKK-NF-kappaB cascade)
event
Positive regulation of B cell receptor signaling (through IKK-NF-kappaB cascade)
event
Positive regulation of B cell receptor signaling pathway (through IKK-NF-kappaB cascade)
Binding of IL-4 receptor and JAK1 and JAK3 in cytosol
event
IMR:0100321
http://purl.org/obo/owl/IMR#IMR_0100321
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0000107
http://purl.org/obo/owl/IMR#IMR_0000107
Phosphorylation of IL-4 receptor by JAK1 and JAK3 in cytosol
event
IMR:0100321
http://purl.org/obo/owl/IMR#IMR_0100321
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0000107
http://purl.org/obo/owl/IMR#IMR_0000107
Binding of IL-4 receptor and STAT6 in cytosol
event
IMR:0000107
http://purl.org/obo/owl/IMR#IMR_0000107
IMR:0000381
http://purl.org/obo/owl/IMR#IMR_0000381
Phosphorylation of STAT6 by JAK1_p and JAK3_p in cytosol
event
IMR:0100321
http://purl.org/obo/owl/IMR#IMR_0100321
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0000381
http://purl.org/obo/owl/IMR#IMR_0000381
Dissociation of IL-4 receptor and STAT6 in cytosol
event
IMR:0000107
http://purl.org/obo/owl/IMR#IMR_0000107
IMR:0000381
http://purl.org/obo/owl/IMR#IMR_0000381
Dimerization of STAT6 in cytosol
event
IMR:0000381
http://purl.org/obo/owl/IMR#IMR_0000381
Nuclear import of STAT6 homodimer
event
IMR:0000381
http://purl.org/obo/owl/IMR#IMR_0000381
Binding of STAT6 homodimer and promoter in inner space of nucleus
event
IGS:0000029
http://purl.org/obo/owl/IGS#IGS_0000029
IMR:0000381
http://purl.org/obo/owl/IMR#IMR_0000381
Dephosphorylation of STAT6 by SHP-1 in cytosol
event
IMR:0000381
http://purl.org/obo/owl/IMR#IMR_0000381
IMR:0000275
http://purl.org/obo/owl/IMR#IMR_0000275
Syk activation signaling
event
PubMed:12461567
http://purl.org/obo/owl/PubMed#PubMed_12461567
Lyn activation signaling
event
PubMed:12461567
http://purl.org/obo/owl/PubMed#PubMed_12461567
Phosphorylation of Ig alpha by Lyn in cytosol
event
PubMed:12461567
http://purl.org/obo/owl/PubMed#PubMed_12461567
IMR:0000211
http://purl.org/obo/owl/IMR#IMR_0000211
IMR:0100541
http://purl.org/obo/owl/IMR#IMR_0100541
Phosphorylation of Ig beta by Lyn in cytosol
event
IMR:0100542
http://purl.org/obo/owl/IMR#IMR_0100542
IMR:0000211
http://purl.org/obo/owl/IMR#IMR_0000211
PubMed:12461567
http://purl.org/obo/owl/PubMed#PubMed_12461567
Binding of Ig beta and Syk in cytosol
event
IMR:0000222
http://purl.org/obo/owl/IMR#IMR_0000222
ISBN:081533642X
http://purl.org/obo/owl/ISBN#ISBN_081533642X
IMR:0100542
http://purl.org/obo/owl/IMR#IMR_0100542
Phosphorylation of BLNK by Syk in cytosol
event
IMR:0000222
http://purl.org/obo/owl/IMR#IMR_0000222
PubMed:152119998
http://purl.org/obo/owl/PubMed#PubMed_152119998
IMR:0000353
http://purl.org/obo/owl/IMR#IMR_0000353
Phosphorylation of PLC gamma2 by Syk in cytosol
event
IMR:0000222
http://purl.org/obo/owl/IMR#IMR_0000222
IMR:0000733
http://purl.org/obo/owl/IMR#IMR_0000733
PubMed:12461567
http://purl.org/obo/owl/PubMed#PubMed_12461567
Phosphorylation of PLC gamma2 by Btk in cytosol
event
PubMed:12461567
http://purl.org/obo/owl/PubMed#PubMed_12461567
IMR:0000733
http://purl.org/obo/owl/IMR#IMR_0000733
IMR:0000215
http://purl.org/obo/owl/IMR#IMR_0000215
Binding of BLNK, BTK, PLC gamma2, Vav and PIP3 in cytosol
event
IMR:0000353
http://purl.org/obo/owl/IMR#IMR_0000353
IMR:0000733
http://purl.org/obo/owl/IMR#IMR_0000733
IMR:0000434
http://purl.org/obo/owl/IMR#IMR_0000434
IMR:0001352
http://purl.org/obo/owl/IMR#IMR_0001352
IMR:0000215
http://purl.org/obo/owl/IMR#IMR_0000215
PubMed:12461567
http://purl.org/obo/owl/PubMed#PubMed_12461567
Binding of BLNK and PLC gamma2 in cytosol
event
PubMed:12461567
http://purl.org/obo/owl/PubMed#PubMed_12461567
IMR:0000353
http://purl.org/obo/owl/IMR#IMR_0000353
IMR:0000733
http://purl.org/obo/owl/IMR#IMR_0000733
Binding of PLC gamma2, BAM32 and PIP3 in cytosol
event
IMR:0002136
http://purl.org/obo/owl/IMR#IMR_0002136
IMR:0001352
http://purl.org/obo/owl/IMR#IMR_0001352
PubMed:12461567
http://purl.org/obo/owl/PubMed#PubMed_12461567
IMR:0000733
http://purl.org/obo/owl/IMR#IMR_0000733
Binding of Btk and PIP3 in cytosol
event
IMR:0000215
http://purl.org/obo/owl/IMR#IMR_0000215
IMR:0001352
http://purl.org/obo/owl/IMR#IMR_0001352
Binding of BAM32 and PIP3 in cytosol
event
IMR:0002136
http://purl.org/obo/owl/IMR#IMR_0002136
IMR:0001352
http://purl.org/obo/owl/IMR#IMR_0001352
Binding of PLC gamma2 and PIP3 in cytosol
event
IMR:0001352
http://purl.org/obo/owl/IMR#IMR_0001352
IMR:0000733
http://purl.org/obo/owl/IMR#IMR_0000733
Binding of CD19 and PI3K in cytosol
event
PubMed:12461567
http://purl.org/obo/owl/PubMed#PubMed_12461567
IMR:0001964
http://purl.org/obo/owl/IMR#IMR_0001964
IMR:0000265
http://purl.org/obo/owl/IMR#IMR_0000265
Activation of IKK complex by PKCs in cytosol
event
IMR:0000243
http://purl.org/obo/owl/IMR#IMR_0000243
PubMed:12461567
http://purl.org/obo/owl/PubMed#PubMed_12461567
IMR:0000245
http://purl.org/obo/owl/IMR#IMR_0000245
Activation of IKK complex by PKC beta in cytosol
event
PubMed:12461567
http://purl.org/obo/owl/PubMed#PubMed_12461567
IMR:0001146
http://purl.org/obo/owl/IMR#IMR_0001146
IMR:0000243
http://purl.org/obo/owl/IMR#IMR_0000243
Binding of GH receptor and JAK2 in cytosol
event
IMR:0100735
http://purl.org/obo/owl/IMR#IMR_0100735
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
Phosphorylation of GH receptor by JAK2 in cytosol
event
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
IMR:0100735
http://purl.org/obo/owl/IMR#IMR_0100735
Binding of GH receptor and STAT5 in cytosol
event
IMR:0100735
http://purl.org/obo/owl/IMR#IMR_0100735
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
Phosphorylation of STAT5 by JAK2_p in cytosol
event
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
Dissociation of GH receptor and STAT5 in cytosol
event
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
IMR:0100735
http://purl.org/obo/owl/IMR#IMR_0100735
Binding of GH and GH receptor and conformational change of receptors in plasma membrane
event
IMR:0100102
http://purl.org/obo/owl/IMR#IMR_0100102
IMR:0100735
http://purl.org/obo/owl/IMR#IMR_0100735
Dephosphorylation of GHR_p by SHP-2 in cytosol
event
IMR:0100735
http://purl.org/obo/owl/IMR#IMR_0100735
IMR:0000276
http://purl.org/obo/owl/IMR#IMR_0000276
Binding of IL3 receptor and JAK2 in cytosol
event
IMR:0000109
http://purl.org/obo/owl/IMR#IMR_0000109
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
Phosphorylation of IL-3 receptor by JAK2 in cytosol
event
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
IMR:0000109
http://purl.org/obo/owl/IMR#IMR_0000109
Binding of IL-3 receptor and STAT5 in cytosol
event
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
IMR:0000109
http://purl.org/obo/owl/IMR#IMR_0000109
Dissociation of IL-3 receptor and STAT5 in cytosol
event
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
IMR:0000109
http://purl.org/obo/owl/IMR#IMR_0000109
Binding of IL-7 receptor and JAK1 and JAK3 in cytosol
event
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0100321
http://purl.org/obo/owl/IMR#IMR_0100321
IMR:0000111
http://purl.org/obo/owl/IMR#IMR_0000111
Phosphorylation of IL-7 receptor by JAK1 and JAK3 in cytosol
event
IMR:0000111
http://purl.org/obo/owl/IMR#IMR_0000111
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0100321
http://purl.org/obo/owl/IMR#IMR_0100321
Binding of IL-7 receptor and STAT5 in cytosol
event
IMR:0000111
http://purl.org/obo/owl/IMR#IMR_0000111
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
Dissociation of IL-7 receptor and STAT5 in cytosol
event
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
IMR:0000111
http://purl.org/obo/owl/IMR#IMR_0000111
Binding of IL-7 and IL-7 receptor and conformational change of receptors in plasma membrane
event
IEV:0001346
Binding of IL7 and IL7 receptor and conformational change of receptors in plasma membrane
IMR:0000586
http://purl.org/obo/owl/IMR#IMR_0000586
GO:0019982
http://purl.org/obo/owl/GO#GO_0019982
Combining with interleukin-7 to initiate a change in cell activity.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
IMR:0000111
http://purl.org/obo/owl/IMR#IMR_0000111
GO:0005139
http://purl.org/obo/owl/GO#GO_0005139
Binding of IL-7 R and PI3K in cytosol
event
IMR:0000111
http://purl.org/obo/owl/IMR#IMR_0000111
IMR:0000265
http://purl.org/obo/owl/IMR#IMR_0000265
Phosphorylation of PI3K by JAK1_p in cytosol
event
IMR:0000265
http://purl.org/obo/owl/IMR#IMR_0000265
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
BMP2 signaling pathway(through Smad)
event
BMP2 signaling pathway(through TAK1)
event
TGF beta signaling pathway (through TAK1)
event
Drosophila Toll-like receptor signaling
event
OBSOLETE: remap to 'Toll receptor signaling' IEV:0003490.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of PGRP-SA and GNBP1 [Drosophila]
event
OBSOLETE: remap to 'Binding of PGRP-SA and GNBP1' IEV:0003496.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of PGRP-SA:GNBP1 and PGN [Drosophila]
event
OBSOLETE: remap to 'Binding of PGRP-SA:GNBP1 and PGN' IEV:0003497.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of PGRP-SD and PGN [Drosophila]
event
OBSOLETE: remap to 'Binding of PGRP-SD and PGN' IEV:0003498.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of GNBP3 and beta1-3 glucan [Drosophila]
event
OBSOLETE: remap to 'Binding of GNBP3 and beta1-3 glucan' IEV:0003494.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Activation of serine protease [Drosophila]
event
OBSOLETE: remap to 'Activation of serine protease' IEV:0003491.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Activation of PSH by GNBP3 [Drosophila]
event
OBSOLETE: remap to 'Activation of PSH by GNBP3' IEV:0003492.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Activation of Spaetzle by serine protease [Drosophila]
event
OBSOLETE: remap to 'Activation of Spaetzle by serine protease' IEV:0003504.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Activation of Spaetzle by PSH [Drosophila]
event
OBSOLETE: remap to 'Activation of Spaetzle by PSH' IEV:0003503.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of Toll and Spaetzle [Drosophila]
event
OBSOLETE: remap to 'Binding of Toll and Spaetzle' IEV:0003500.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Dimerization of Toll by Spaetzle [Drosophila]
event
OBSOLETE: remap to 'Dimerization of Toll by Spaetzle' IEV:0003529.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of Toll and dMyD88:Tube [Drosophila]
event
OBSOLETE: remap to 'Binding of Toll and MyD88:Tube' IEV:0003499.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of Toll:dMyD88:Tube and Pelle [Drosophila]
event
OBSOLETE: remap to 'Binding of Toll:MyD88:Tube and Pelle' IEV:0003501.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Autophosphorylation of Pelle [Drosophila]
event
OBSOLETE: remap to 'Autophosphorylation of Pelle' IEV:0003493.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Dissociation of Toll:dMyD88:Tube and Pelle [Drosophila]
event
OBSOLETE: remap to 'Dissociation of Toll:MyD88:Tube and Pelle' IEV:0003530.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Phosphorylation of dTRAF2 by Pelle_p [Drosophila]
event
OBSOLETE: remap to 'Phosphorylation of TRAF2 by Pelle_p' IEV:0003540.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of dTRAF2 and Ref(2):DaPKC [Drosophila]
event
OBSOLETE: remap to 'Binding of TRAF2 and Ref(2):DaPKC' IEV:0003495.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Nuclear import of dTRAF2:Ref(2)P:DaPKC [Drosophila]
event
OBSOLETE: remap to 'Nuclear import of TRAF2:Ref(2)P:DaPKC' IEV:0003539.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Phosphorylation of Cactus [Drosophila]
event
OBSOLETE: remap to 'Phosphorylation of Cactus' IEV:0003522.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Dissociation of Cactus_p and DIF [Drosophila]
event
OBSOLETE: remap to 'Dissociation of Cactus_p and DIF' IEV:0003510.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Dissociation of Cactus_p and Dorsal:DIF [Drosophila]
event
OBSOLETE: remap to 'Dissociation of Cactus_p and Dorsal:DIF' IEV:0003524.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Nuclear import of DIF [Drosophila]
event
OBSOLETE: remap to 'Nuclear import of DIF' IEV:0003521.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Nuclear import of Dorsal [Drosophila]
event
OBSOLETE: remap to 'Nuclear import of Dorsal' IEV:0003538.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Nuclear import of Dorsal:DIF [Drosophila]
event
OBSOLETE: remap to 'Nuclear import of Dorsal:DIF' IEV:0003528.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Activation of DIF [Drosophila]
event
OBSOLETE: remap to 'Activation of DIF' IEV:0003509.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Activation of Dorsal [Drosophila]
event
OBSOLETE: remap to 'Activation of Dorsal' IEV:0003531.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Activation of DIF:Dorsal [Drosophila]
event
OBSOLETE: remap to 'Activation of DIF:Dorsal' IEV:0003523.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of DIF and NF-kappaB binding sequence [Drosophila]
event
OBSOLETE: remap to 'Binding of DIF and NF-kappaB binding sequence' IEV:0003512.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of Dorsal and NF-kappaB binding sequence [Drosophila]
event
OBSOLETE: remap to 'Binding of Dorsal and NF-kappaB binding sequence' IEV:0003534.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of DIF:Dorsal and NF-kappaB binding sequence [Drosophila]
event
OBSOLETE: remap to 'Binding of DIF:Dorsal and NF-kappaB binding sequence' IEV:0003526.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Transcription of antimicrobial peptide by DIF [Drosophila]
event
OBSOLETE: remap to 'Transcription of antimicrobial peptide by DIF' IEV:0003517.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Transcription of antimicrobial peptide by Dorsal [Drosophila]
event
OBSOLETE: remap to 'Transcription of antimicrobial peptide by Dorsal' IEV:0003537.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Transcription of antimicrobial peptide by DIF:Dorsal [Drosophila]
event
OBSOLETE: remap to 'Transcription of antimicrobial peptide by DIF:Dorsal' IEV:0003527.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
DIF signaling [Drosophila]
event
OBSOLETE: remap to 'DIF signaling' IEV:0003506.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Dorsal signaling [Drosophila]
event
OBSOLETE: remap to 'Dorsal signaling' IEV:0003507.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
DIF:Dorsal signaling [Drosophila]
event
OBSOLETE: remap to 'DIF:Dorsal signaling' IEV:0003508.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Expression of antimicrobial peptide by Relish [Drosophila]
event
OBSOLETE: remap to 'Expression of antimicrobial peptide by Relish' IEV:0003464.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Expression of drosomycin by Relish [Drosophila]
event
OBSOLETE: remap to 'Expression of drosomycin by Relish' IEV:0003475.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Expression of cecropin by Relish [Drosophila]
event
OBSOLETE: remap to 'Expression of cecropin by Relish' IEV:0002644.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Expression of diptericin by Relish [Drosophila]
event
OBSOLETE: remap to 'Expression of diptericin by Relish' IEV:0003472.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Drosophila IMD pathway [Drosophila]
event
OBSOLETE: remap to 'IMD signaling pathway' IEV:0003456.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of PGRP-LC and PGN [Drosophila]
event
OBSOLETE: remap to 'Binding of PGRP-LC and PGN' IEV:0003465.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of PGRP-LC and LPS [Drosophila]
event
OBSOLETE: remap to 'Binding of PGRP-LC and LPS' IEV:0003457.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of PGRP-LE and PGN [Drosophila]
event
OBSOLETE: remap to 'Binding of PGRP-LE and PGN' IEV:0003466.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of PGRP-LC and IMD [Drosophila]
event
OBSOLETE: remap to 'Binding of PGRP-LC and IMD' IEV:0003461.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of IMD and dFADD [Drosophila]
event
OBSOLETE: remap to 'Binding of IMD and FADD' IEV:0003463.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of dFADD and Dredd [Drosophila]
event
OBSOLETE: remap to 'Binding of FADD and caspase8' IEV:0003458.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of Dnr-1 and Dredd [Drosophila]
event
OBSOLETE: remap to 'Binding of Dnr-1 and caspase8' IEV:0003462.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Activation of TAK1 by IMD [Drosophila]
event
OBSOLETE: remap to 'Activation of TAK1 by IMD' IEV:0003459.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Phosphorylation of DmIKK by TAK1 [Drosophila]
event
OBSOLETE: remap to 'Phosphorylation of IKK complex by TAK1' IEV:0000784.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Phosphorylation of Relish by IKK [Drosophila]
event
OBSOLETE: remap to 'Phosphorylation of Relish by IKK' IEV:0003469.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Cleavage and activation of Relish by Dredd [Drosophila]
event
OBSOLETE: remap to 'Cleavage and activation of Relish by caspase8' IEV:0003467.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Nuclear import of Relish [Drosophila]
event
OBSOLETE: remap to 'Nuclear import of Relish' IEV:0003471.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of Relish and NF-kappaB binding sequence [Drosophila]
event
OBSOLETE: remap to 'Binding of Relish and NF-kappaB binding sequence' IEV:0003468.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Transcription of antimicrobial peptide by Relish [Drosophila]
event
OBSOLETE: remap to 'Transcription of antimicrobial peptide by Relish' IEV:0003478.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Expression of drosocin by Relish [Drosophila]
event
OBSOLETE: remap to 'Expression of drosocin by Relish' IEV:0003473.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Expression of attacin by Relish [Drosophila]
event
OBSOLETE: remap to 'Expression of attacin by Relish' IEV:0003474.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Expression of defensin by DIF:Relish [Drosophila]
event
OBSOLETE: remap to 'Expression of defensin by DIF:Relish' IEV:0003477.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Dissociation of Cactus_p and Dorsal [Drosophila]
event
OBSOLETE: remap to 'Dissociation of Cactus_p and Dorsal' IEV:0003532.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Transacetylation
event
MI:0192
http://purl.org/obo/owl/MI#MI_0192
EC:2.3.1.87
http://purl.org/obo/owl/EC#EC_2.3.1.87
EC:2.3.1.12
http://purl.org/obo/owl/EC#EC_2.3.1.12
EC:2.3.1.9
http://purl.org/obo/owl/EC#EC_2.3.1.9
EC:2.3.1.57
http://purl.org/obo/owl/EC#EC_2.3.1.57
Reaction, that can affect K,C,A,D,E,Q,G,I,K,M,P,S,T,Y,V residues.
MI:0192
http://purl.org/obo/owl/MI#MI_0192
EC:2.3.1.4
http://purl.org/obo/owl/EC#EC_2.3.1.4
EC:2.3.1.29
http://purl.org/obo/owl/EC#EC_2.3.1.29
Binding of Angiotensin II and AT1R in extracellular
event
IMR:0100150
http://purl.org/obo/owl/IMR#IMR_0100150
IMR:0001721
http://purl.org/obo/owl/IMR#IMR_0001721
Binding of AT1R and G alpha q in cytosol
event
IMR:0001721
http://purl.org/obo/owl/IMR#IMR_0001721
IMR:0100378
http://purl.org/obo/owl/IMR#IMR_0100378
Dissociation of AT1R, G alpha s-GTP and G beta:G gamma in cytosol
event
IMR:0100366
http://purl.org/obo/owl/IMR#IMR_0100366
IMR:0100018
http://purl.org/obo/owl/IMR#IMR_0100018
IMR:0001721
http://purl.org/obo/owl/IMR#IMR_0001721
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Binding of G alpha q-GTP and PLC in cytosol
event
IMR:0000284
http://purl.org/obo/owl/IMR#IMR_0000284
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0100378
http://purl.org/obo/owl/IMR#IMR_0100378
Binding of Glutamate and Group I mGlu receptor in extracellular
event
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0001729
http://purl.org/obo/owl/IMR#IMR_0001729
Binding of Group I mGlu receptor and G alpha q in cytosol
event
IMR:0001729
http://purl.org/obo/owl/IMR#IMR_0001729
IMR:0100378
http://purl.org/obo/owl/IMR#IMR_0100378
Dissociation of Group I mGlu receptor, G alpha q-GTP and G beta:G gamma in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0100018
http://purl.org/obo/owl/IMR#IMR_0100018
IMR:0001729
http://purl.org/obo/owl/IMR#IMR_0001729
IMR:0100378
http://purl.org/obo/owl/IMR#IMR_0100378
Dissociation of NF-kappaB and I-kappaB [mammals]
event
OBSOLETE: remap to 'Dissociation of NF-kappaB and I-kappaB' IEV:0000215.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
TNFR1 signaling pathway
event
REACT:1432.1
http://purl.org/obo/owl/REACT#REACT_1432.1
TNFR2 signaling pathway
event
Phosphorylation of I-kappaB_p by IKK complex_p [mammals]
event
OBSOLETE: remap to 'Phosphorylation of I-kappaB_p by IKK complex_p in cytosol' IEV:0000213.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of TRAF6:TAK1:TAB1:TAB2 complex and ubiquitin ligase in cytosol
event
IMR:0000893
http://purl.org/obo/owl/IMR#IMR_0000893
IMR:0000441
http://purl.org/obo/owl/IMR#IMR_0000441
IMR:0000329
http://purl.org/obo/owl/IMR#IMR_0000329
IMR:0000232
http://purl.org/obo/owl/IMR#IMR_0000232
PubMed:12620219
http://purl.org/obo/owl/PubMed#PubMed_12620219
IMR:0100427
http://purl.org/obo/owl/IMR#IMR_0100427
Phosphorylation of p38 by KDR_p in cytosol
event
IMR:0000226
http://purl.org/obo/owl/IMR#IMR_0000226
IMR:0000066
http://purl.org/obo/owl/IMR#IMR_0000066
Phosphorylation of MAPKAPK2/3 by p38_p in cytosol
event
IMR:0000226
http://purl.org/obo/owl/IMR#IMR_0000226
IMR:0001689
http://purl.org/obo/owl/IMR#IMR_0001689
Phosphorylation of HSP27 by MAPKAPK2/3_p in cytosol
event
IMR:0001692
http://purl.org/obo/owl/IMR#IMR_0001692
IMR:0001689
http://purl.org/obo/owl/IMR#IMR_0001689
Phosphorylation of Akt by protein kinase in cytosol
event
IMR:0000209
http://purl.org/obo/owl/IMR#IMR_0000209
IMR:0000250
http://purl.org/obo/owl/IMR#IMR_0000250
Binding of Dopamine and D1-like receptor in extracellular
event
IMR:0100113
http://purl.org/obo/owl/IMR#IMR_0100113
IMR:0001761
http://purl.org/obo/owl/IMR#IMR_0001761
Binding of D1-like receptor and G alpha s in cytosol
event
IMR:0100366
http://purl.org/obo/owl/IMR#IMR_0100366
IMR:0001761
http://purl.org/obo/owl/IMR#IMR_0001761
Dissociation of D1-like receptor, G alpha s-GTP and G beta:G gamma in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0100366
http://purl.org/obo/owl/IMR#IMR_0100366
IMR:0100018
http://purl.org/obo/owl/IMR#IMR_0100018
IMR:0001761
http://purl.org/obo/owl/IMR#IMR_0001761
Binding of G alpha s-GTP and adenylate cyclase type V in cytosol
event
IMR:0100366
http://purl.org/obo/owl/IMR#IMR_0100366
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000722
http://purl.org/obo/owl/IMR#IMR_0000722
Hydrolysis of ATP to cAMP by adenylate cyclase type V in cytosol
event
IMR:0100024
http://purl.org/obo/owl/IMR#IMR_0100024
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0000722
http://purl.org/obo/owl/IMR#IMR_0000722
Phosphorylation of CREB by PKA in cytosol
event
IMR:0000249
http://purl.org/obo/owl/IMR#IMR_0000249
IMR:0000420
http://purl.org/obo/owl/IMR#IMR_0000420
Activation of PP2A by PKA in cytosol
event
IMR:0000280
http://purl.org/obo/owl/IMR#IMR_0000280
IMR:0000249
http://purl.org/obo/owl/IMR#IMR_0000249
Phosphorylation of DARPP-32 by PKA in cytosol
event
IMR:0001763
http://purl.org/obo/owl/IMR#IMR_0001763
IMR:0000249
http://purl.org/obo/owl/IMR#IMR_0000249
Dephosphorylation of NMDA glutamate receptor by PP1 in cytosol
event
IMR:0000279
http://purl.org/obo/owl/IMR#IMR_0000279
IMR:0000083
http://purl.org/obo/owl/IMR#IMR_0000083
Dephosphorylation of L-type Ca2+ channel_p by PP1 in cytosol
event
IMR:0000749
http://purl.org/obo/owl/IMR#IMR_0000749
IMR:0000279
http://purl.org/obo/owl/IMR#IMR_0000279
Phosphorylation of L-type Ca2+ channel by PKA in cytosol
event
IMR:0000249
http://purl.org/obo/owl/IMR#IMR_0000249
IMR:0000749
http://purl.org/obo/owl/IMR#IMR_0000749
Phosphorylation of NMDA glutamate receptor by PKA in cytosol
event
IMR:0000249
http://purl.org/obo/owl/IMR#IMR_0000249
IMR:0000083
http://purl.org/obo/owl/IMR#IMR_0000083
Phosphorylation of DARPP-32 by CDK5 in cytosol
event
IMR:0001763
http://purl.org/obo/owl/IMR#IMR_0001763
IMR:0100601
http://purl.org/obo/owl/IMR#IMR_0100601
Dephosphorylation of DARPP-32_p by PP2A in cytosol
event
IMR:0001763
http://purl.org/obo/owl/IMR#IMR_0001763
IMR:0000280
http://purl.org/obo/owl/IMR#IMR_0000280
Binding of TGF beta receptor I and XIAP in cytosol
event
PubMed:14687659
http://purl.org/obo/owl/PubMed#PubMed_14687659
PubMed:15733830
http://purl.org/obo/owl/PubMed#PubMed_15733830
IMR:0000710
http://purl.org/obo/owl/IMR#IMR_0000710
IMR:0100331
http://purl.org/obo/owl/IMR#IMR_0100331
Binding of XIAP and TAB1 in cytosol
event
PubMed:14687659
http://purl.org/obo/owl/PubMed#PubMed_14687659
PubMed:15733830
http://purl.org/obo/owl/PubMed#PubMed_15733830
IMR:0000441
http://purl.org/obo/owl/IMR#IMR_0000441
IMR:0100331
http://purl.org/obo/owl/IMR#IMR_0100331
Activation of TAK1 by TAB1 in cytosol
event
PubMed:15733830
http://purl.org/obo/owl/PubMed#PubMed_15733830
PubMed:14687659
http://purl.org/obo/owl/PubMed#PubMed_14687659
IMR:0000232
http://purl.org/obo/owl/IMR#IMR_0000232
IMR:0000441
http://purl.org/obo/owl/IMR#IMR_0000441
Phosphorylation of MKK4 by MEKK1 in cytosol
event
ISBN:4897065739
http://purl.org/obo/owl/ISBN#ISBN_4897065739
ISBN:4897060729
http://purl.org/obo/owl/ISBN#ISBN_4897060729
IMR:0100222
http://purl.org/obo/owl/IMR#IMR_0100222
ISBN:4320055608
http://purl.org/obo/owl/ISBN#ISBN_4320055608
IMR:0100454
http://purl.org/obo/owl/IMR#IMR_0100454
Phosphorylation of JNK1 by MKK4_p in cytosol
event
ISBN:4897065739
http://purl.org/obo/owl/ISBN#ISBN_4897065739
IMR:0100454
http://purl.org/obo/owl/IMR#IMR_0100454
ISBN:4320055608
http://purl.org/obo/owl/ISBN#ISBN_4320055608
ISBN:4897060729
http://purl.org/obo/owl/ISBN#ISBN_4897060729
IMR:0000683
http://purl.org/obo/owl/IMR#IMR_0000683
Nuclear import of JNK1_p
event
ISBN:4897060729
http://purl.org/obo/owl/ISBN#ISBN_4897060729
ISBN:4897065739
http://purl.org/obo/owl/ISBN#ISBN_4897065739
IMR:0000683
http://purl.org/obo/owl/IMR#IMR_0000683
ISBN:4320055608
http://purl.org/obo/owl/ISBN#ISBN_4320055608
Phosphorylation of c-Jun by JNK1_p in inner space of nucleus
event
IMR:0000683
http://purl.org/obo/owl/IMR#IMR_0000683
ISBN:4320055608
http://purl.org/obo/owl/ISBN#ISBN_4320055608
IMR:0000817
http://purl.org/obo/owl/IMR#IMR_0000817
ISBN:4897065739
http://purl.org/obo/owl/ISBN#ISBN_4897065739
ISBN:4897060729
http://purl.org/obo/owl/ISBN#ISBN_4897060729
PKC delta activation signaling
event
Activation of PKC delta by DAG in cytosol
event
IMR:0001148
http://purl.org/obo/owl/IMR#IMR_0001148
IMR:0100027
http://purl.org/obo/owl/IMR#IMR_0100027
Binding of EGF and EGFR in extracellular
event
IMR:0100279
http://purl.org/obo/owl/IMR#IMR_0100279
IMR:0000081
http://purl.org/obo/owl/IMR#IMR_0000081
Dimerization of EGFR in plasma membrane
event
IMR:0000081
http://purl.org/obo/owl/IMR#IMR_0000081
Autophosphorylation of EGFR in plasma membrane
event
IMR:0000081
http://purl.org/obo/owl/IMR#IMR_0000081
Phosphorylation of Shc by EGFR_p in cytosol
event
IMR:0000081
http://purl.org/obo/owl/IMR#IMR_0000081
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
Binding of Sos and Ras in cytosol
event
IMR:0000290
http://purl.org/obo/owl/IMR#IMR_0000290
IMR:0000435
http://purl.org/obo/owl/IMR#IMR_0000435
Activation of Raf1 by Ras-GTP in cytosol
event
IMR:0100355
http://purl.org/obo/owl/IMR#IMR_0100355
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000290
http://purl.org/obo/owl/IMR#IMR_0000290
Activation of MEKK1 by Ras-GTP in cytosol
event
IMR:0000290
http://purl.org/obo/owl/IMR#IMR_0000290
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0100222
http://purl.org/obo/owl/IMR#IMR_0100222
Phosphorylation of MEK1/2(MKK1/2) by Raf1 in cytosol
event
IMR:0100355
http://purl.org/obo/owl/IMR#IMR_0100355
IMR:0000261
http://purl.org/obo/owl/IMR#IMR_0000261
Phosphorylation of ERK1/2 by MEK1/2(MKK1/2)_p in cytosol
event
IMR:0000227
http://purl.org/obo/owl/IMR#IMR_0000227
IMR:0000261
http://purl.org/obo/owl/IMR#IMR_0000261
Phosphorylation of Shc by PDGF Receptor_p in cytosol
event
IMR:0000068
http://purl.org/obo/owl/IMR#IMR_0000068
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
Binding of HGF and Met in extracellular
event
IMR:0000071
http://purl.org/obo/owl/IMR#IMR_0000071
IMR:0000033
http://purl.org/obo/owl/IMR#IMR_0000033
Dimerization of Met in plasma membrane
event
IMR:0000071
http://purl.org/obo/owl/IMR#IMR_0000071
Autophosphorylation of Met in plasma membrane
event
IMR:0000071
http://purl.org/obo/owl/IMR#IMR_0000071
Binding of Met_p and Src in cytosol
event
IMR:0100575
http://purl.org/obo/owl/IMR#IMR_0100575
IMR:0000071
http://purl.org/obo/owl/IMR#IMR_0000071
Binding of Met_p and Gab1 in cytosol
event
IMR:0000071
http://purl.org/obo/owl/IMR#IMR_0000071
IMR:0001410
http://purl.org/obo/owl/IMR#IMR_0001410
Binding of Met_p and Grb2 in cytosol
event
IEV:0002468
IMR:0000340
http://purl.org/obo/owl/IMR#IMR_0000340
IMR:0000071
http://purl.org/obo/owl/IMR#IMR_0000071
Binding of (HGF:Met_p) and (Grb2:Sos)
Binding of Gab1 and Grb2 in cytosol
event
IMR:0001410
http://purl.org/obo/owl/IMR#IMR_0001410
IMR:0000340
http://purl.org/obo/owl/IMR#IMR_0000340
Binding of Gab1 and PLC gamma in cytosol
event
IMR:0000285
http://purl.org/obo/owl/IMR#IMR_0000285
IMR:0001410
http://purl.org/obo/owl/IMR#IMR_0001410
Binding of Gab1 and SHP-2 in cytosol
event
IMR:0000276
http://purl.org/obo/owl/IMR#IMR_0000276
IMR:0001410
http://purl.org/obo/owl/IMR#IMR_0001410
Binding of Gab1 and Crk in cytosol
event
IMR:0000335
http://purl.org/obo/owl/IMR#IMR_0000335
IMR:0001410
http://purl.org/obo/owl/IMR#IMR_0001410
Binding of Crk and Dock180 in cytosol
event
IMR:0001468
http://purl.org/obo/owl/IMR#IMR_0001468
IMR:0000335
http://purl.org/obo/owl/IMR#IMR_0000335
Binding of Dock180 and Rac in cytosol
event
IMR:0001468
http://purl.org/obo/owl/IMR#IMR_0001468
IMR:0000297
http://purl.org/obo/owl/IMR#IMR_0000297
Binding of C3G and Rap1 in cytosol
event
IMR:0000436
http://purl.org/obo/owl/IMR#IMR_0000436
IMR:0001504
http://purl.org/obo/owl/IMR#IMR_0001504
Phosphorylation of Shc by Met_p in cytosol
event
IMR:0000071
http://purl.org/obo/owl/IMR#IMR_0000071
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
Binding of NGF and TRK in extracellular
event
IMR:0100407
http://purl.org/obo/owl/IMR#IMR_0100407
IMR:0000072
http://purl.org/obo/owl/IMR#IMR_0000072
Dimerization of TRK in plasma membrane
event
IMR:0000072
http://purl.org/obo/owl/IMR#IMR_0000072
Autophosphorylation of TRK in plasma membrane
event
IMR:0000072
http://purl.org/obo/owl/IMR#IMR_0000072
Phosphorylation of Shc by TRK_p in cytosol
event
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
IMR:0000072
http://purl.org/obo/owl/IMR#IMR_0000072
Binding of TRK_p and PLC gamma in cytosol
event
IMR:0000072
http://purl.org/obo/owl/IMR#IMR_0000072
IMR:0000285
http://purl.org/obo/owl/IMR#IMR_0000285
Phosphorylation of PLC gamma by TRK_p in cytosol
event
IMR:0000072
http://purl.org/obo/owl/IMR#IMR_0000072
IMR:0000285
http://purl.org/obo/owl/IMR#IMR_0000285
Binding of VEGF and KDR in extracellular
event
IMR:0000066
http://purl.org/obo/owl/IMR#IMR_0000066
IMR:0000031
http://purl.org/obo/owl/IMR#IMR_0000031
Dimerization of KDR in plasma membrane
event
IMR:0000066
http://purl.org/obo/owl/IMR#IMR_0000066
Autophosphorylation of KDR in plasma membrane
event
IMR:0000066
http://purl.org/obo/owl/IMR#IMR_0000066
Binding of KDR_p and PI3K in cytosol
event
IMR:0000066
http://purl.org/obo/owl/IMR#IMR_0000066
IMR:0000265
http://purl.org/obo/owl/IMR#IMR_0000265
Binding of KDR_p and VRAP in cytosol
event
IMR:0001652
http://purl.org/obo/owl/IMR#IMR_0001652
IMR:0000066
http://purl.org/obo/owl/IMR#IMR_0000066
Binding of KDR_p and PLC gamma in cytosol
event
IMR:0000285
http://purl.org/obo/owl/IMR#IMR_0000285
IMR:0000066
http://purl.org/obo/owl/IMR#IMR_0000066
Activation of PKC by DAG in cytosol
event
IMR:0100027
http://purl.org/obo/owl/IMR#IMR_0100027
IMR:0000245
http://purl.org/obo/owl/IMR#IMR_0000245
Activation of Raf-1 by PKC in cytosol
event
Activation of c-Raf1 by PKC
IMR:0100355
http://purl.org/obo/owl/IMR#IMR_0100355
IMR:0000245
http://purl.org/obo/owl/IMR#IMR_0000245
Binding of FGF and FGFR in extracellular
event
IMR:0000049
http://purl.org/obo/owl/IMR#IMR_0000049
IMR:0000080
http://purl.org/obo/owl/IMR#IMR_0000080
Dimerization of FGFR in plasma membrane
event
IMR:0000080
http://purl.org/obo/owl/IMR#IMR_0000080
Autophosphorylation of FGFR in plasma membrane
event
IMR:0000080
http://purl.org/obo/owl/IMR#IMR_0000080
Binding of FGFR_p and PLC gamma in cytosol
event
IMR:0000285
http://purl.org/obo/owl/IMR#IMR_0000285
IMR:0000080
http://purl.org/obo/owl/IMR#IMR_0000080
Binding of FGFR_p and FRS2 in cytosol
event
IMR:0001836
http://purl.org/obo/owl/IMR#IMR_0001836
IMR:0000080
http://purl.org/obo/owl/IMR#IMR_0000080
Phosphorylation of FRS2 by FGFR_p in cytosol
event
IMR:0001836
http://purl.org/obo/owl/IMR#IMR_0001836
IMR:0000080
http://purl.org/obo/owl/IMR#IMR_0000080
Binding of Grb2 and FRS2_p in cytosol
event
IMR:0000340
http://purl.org/obo/owl/IMR#IMR_0000340
IMR:0001836
http://purl.org/obo/owl/IMR#IMR_0001836
Phosphorylation of Gab1 by FRS2 in cytosol
event
IMR:0001410
http://purl.org/obo/owl/IMR#IMR_0001410
IMR:0001836
http://purl.org/obo/owl/IMR#IMR_0001836
Binding of Gab1_p and PI3K in cytosol
IEV:0002462
event
IMR:0000265
http://purl.org/obo/owl/IMR#IMR_0000265
IMR:0001410
http://purl.org/obo/owl/IMR#IMR_0001410
Binding of Gab1 and PI3K
Binding of Ras and PI3K in cytosol
event
IMR:0000290
http://purl.org/obo/owl/IMR#IMR_0000290
IMR:0000265
http://purl.org/obo/owl/IMR#IMR_0000265
Binding of Ci/Gli and Slmb/beta-TrCP in cytosol
event
IMR:0100471
http://purl.org/obo/owl/IMR#IMR_0100471
IMR:0001372
http://purl.org/obo/owl/IMR#IMR_0001372
Binding of BMP2:BMP receptor I and BMP receptor II in plasma membrane
event
IMR:0000702
http://purl.org/obo/owl/IMR#IMR_0000702
IMR:0001424
http://purl.org/obo/owl/IMR#IMR_0001424
IMR:0001425
http://purl.org/obo/owl/IMR#IMR_0001425
Binding of BMP receptor I and XIAP in cytosol
event
IMR:0001425
http://purl.org/obo/owl/IMR#IMR_0001425
IMR:0100331
http://purl.org/obo/owl/IMR#IMR_0100331
Binding of Smad6 and TAK1 in cytosol
event
IMR:0000232
http://purl.org/obo/owl/IMR#IMR_0000232
IMR:0100317
http://purl.org/obo/owl/IMR#IMR_0100317
Ventral mesoderm specification
event
Regulation of BMP2 signaling pathway (through Smad)
event
Negative regulation of BMP2 signaling pathway (through Smad)
event
Positive regulation of BMP2 signaling pathway (through Smad)
event
Regulation of BMP2 signaling pathway (through TAK1)
event
Negative regulation of BMP2 signaling pathway (through TAK1)
event
Positive regulation of BMP2 signaling pathway (through TAK1)
event
Binding of BMP receptor II and BAMBI in cytosol
event
IMR:0000702
http://purl.org/obo/owl/IMR#IMR_0000702
IMR:0001831
http://purl.org/obo/owl/IMR#IMR_0001831
Binding of BMP receptor I and Smad7 in cytosol
event
IMR:0001425
http://purl.org/obo/owl/IMR#IMR_0001425
IMR:0100318
http://purl.org/obo/owl/IMR#IMR_0100318
Binding of BMP receptor I and Smad6 in cytosol
event
IMR:0001425
http://purl.org/obo/owl/IMR#IMR_0001425
IMR:0100317
http://purl.org/obo/owl/IMR#IMR_0100317
Binding of Smad1_p and Smad6 in cytosol
event
IMR:0100310
http://purl.org/obo/owl/IMR#IMR_0100310
IMR:0100317
http://purl.org/obo/owl/IMR#IMR_0100317
Binding of DIF:Relish and NF-kappaB binding sequence [Drosophila]
event
OBSOLETE: remap to 'Binding of DIF:Relish and NF-kappaB binding sequence' IEV:0003460.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Transcription of defensin by DIF:Relish [Drosophila]
event
OBSOLETE: remap to 'Transcription of defensin by DIF:Relish' IEV:0003481.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Regulation of Drosophila Toll receptor signaling
event
OBSOLETE: remap to 'Regulation of Toll receptor signaling' IEV:0003569.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Negative regulation of Toll receptor signaling
event
Negative regulation of Toll receptor signaling pathway
Any process that stops, prevents or reduces the frequency, rate or extent of the Tl signaling pathway.
GO:0045751
http://purl.org/obo/owl/GO#GO_0045751
GO:0045751
http://purl.org/obo/owl/GO#GO_0045751
negative regulation of Tl signaling pathway
down regulation of Toll signaling pathway
Positive regulation of Toll receptor signaling
event
GO:0045752
http://purl.org/obo/owl/GO#GO_0045752
Positive regulation of Toll receptor signaling pathway
positive regulation of Tl signaling pathway
Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway.
GO:0045752
http://purl.org/obo/owl/GO#GO_0045752
up regulation of Toll signaling pathway
Negative regulation of (Activation of PSH by GNBP3)
event
Binding of PSH and NEC in extracellular
event
IMR:0001796
http://purl.org/obo/owl/IMR#IMR_0001796
IMR:0001797
http://purl.org/obo/owl/IMR#IMR_0001797
Proteasome degradation of Cactus_p by 26S proteasome in cytosol
event
IMR:0001805
http://purl.org/obo/owl/IMR#IMR_0001805
IMR:0000310
http://purl.org/obo/owl/IMR#IMR_0000310
Cellular defense (Activated blood cell)
event
GO:0006968
http://purl.org/obo/owl/GO#GO_0006968
A defense response that is mediated by cells.
GO:0006968
http://purl.org/obo/owl/GO#GO_0006968
cellular defense response
GO:0006968
http://purl.org/obo/owl/GO#GO_0006968
Phosphorylation of Smad1 by BMP receptor I_p in cytosol
event
IMR:0100310
http://purl.org/obo/owl/IMR#IMR_0100310
IMR:0001425
http://purl.org/obo/owl/IMR#IMR_0001425
Binding of Smad1_p:Smad4 and OAZ in inner space of nucleus
event
IMR:0001948
http://purl.org/obo/owl/IMR#IMR_0001948
IMR:0100310
http://purl.org/obo/owl/IMR#IMR_0100310
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
Binding of Smad1:Smad4:OAZ complex and BRE in inner space of nucleus
event
IMR:0001948
http://purl.org/obo/owl/IMR#IMR_0001948
IMR:0100310
http://purl.org/obo/owl/IMR#IMR_0100310
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
Clustering of integrins in plasma membrane
event
IMR:0000172
http://purl.org/obo/owl/IMR#IMR_0000172
PubMed:15179030
http://purl.org/obo/owl/PubMed#PubMed_15179030
PubMed:10446041
http://purl.org/obo/owl/PubMed#PubMed_10446041
Clustering
event
Clustering in plasma membrane
event
Complex formation of integrin complex, caveolin-1, Fyn and Shc
event
IMR:0100352
http://purl.org/obo/owl/IMR#IMR_0100352
IMR:0000172
http://purl.org/obo/owl/IMR#IMR_0000172
IMR:0001647
http://purl.org/obo/owl/IMR#IMR_0001647
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
Binding of integrin alpha and caveolin-1 in plasma membrane
event
IMR:0000173
http://purl.org/obo/owl/IMR#IMR_0000173
IMR:0001647
http://purl.org/obo/owl/IMR#IMR_0001647
Binding of caveolin-1 and Fyn in plasma membrane
event
IMR:0100352
http://purl.org/obo/owl/IMR#IMR_0100352
IMR:0001647
http://purl.org/obo/owl/IMR#IMR_0001647
Complex formation of integrin complex, caveolin, Fyn and Shc
event
IMR:0000515
http://purl.org/obo/owl/IMR#IMR_0000515
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
IMR:0100352
http://purl.org/obo/owl/IMR#IMR_0100352
IMR:0000172
http://purl.org/obo/owl/IMR#IMR_0000172
GDP-GTP exchange of Rac1 by RhoGEF in cytosol
event
IMR:0001954
http://purl.org/obo/owl/IMR#IMR_0001954
IMR:0001501
http://purl.org/obo/owl/IMR#IMR_0001501
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
GDP-GTP exchange of Cdc42 by RhoGEF in cytosol
event
IMR:0000699
http://purl.org/obo/owl/IMR#IMR_0000699
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0001954
http://purl.org/obo/owl/IMR#IMR_0001954
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
GDP-GTP exchange of RhoA by RhoGEF in cytosol
event
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0001954
http://purl.org/obo/owl/IMR#IMR_0001954
IMR:0001953
http://purl.org/obo/owl/IMR#IMR_0001953
Transcription of cyclin D1 gene in nucleus
event
IMR:0100615
http://purl.org/obo/owl/IMR#IMR_0100615
Filopodium formation
event
The assembly of a filopodium, a very long microspike extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or by the growth cone of a developing nerve cell axon.
GO:0046847
http://purl.org/obo/owl/GO#GO_0046847
filopodia biosynthesis
filopodia formation
GO:0046847
http://purl.org/obo/owl/GO#GO_0046847
Cell fate determination
event
GO:0001709
http://purl.org/obo/owl/GO#GO_0001709
Process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.
GO:0001709
http://purl.org/obo/owl/GO#GO_0001709
Mesodermal cell fate determination
event
mesoderm cell fate determination
GO:0007500
http://purl.org/obo/owl/GO#GO_0007500
GO:0007500
http://purl.org/obo/owl/GO#GO_0007500
Process by which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.
GO:0007500
http://purl.org/obo/owl/GO#GO_0007500
Mesoderm development
event
GO:0007498
http://purl.org/obo/owl/GO#GO_0007498
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
GO:0007498
http://purl.org/obo/owl/GO#GO_0007498
Mesoderm morphogenesis
event
GO:0048332
http://purl.org/obo/owl/GO#GO_0048332
Wnt secretory pathway
event
Endoderm development
event
GO:0007492
http://purl.org/obo/owl/GO#GO_0007492
The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.
GO:0007492
http://purl.org/obo/owl/GO#GO_0007492
Endodermal cell fate determination
event
GO:0007493
http://purl.org/obo/owl/GO#GO_0007493
endoderm cell fate determination
GO:0007493
http://purl.org/obo/owl/GO#GO_0007493
Process by which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.
GO:0007493
http://purl.org/obo/owl/GO#GO_0007493
Signaling with Wnt
event
REACT:11045.1
http://purl.org/obo/owl/REACT#REACT_11045.1
Signaling without Wnt
event
Stabilization and accumulation of cytoplasmic beta-catenin in cytosol
event
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
Accumulation
event
Accumulation in cytosol
event
Transcription of Ubx gene in nucleus
event
IMR:0001978
http://purl.org/obo/owl/IMR#IMR_0001978
Transcription of Engrailed gene in nucleus
event
IMR:0001979
http://purl.org/obo/owl/IMR#IMR_0001979
Wnt signaling pathway (C. elegans)
event
OBSOLETE: remap to 'Wnt signaling pathway' IEV:0000027.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Transcription of end-1 gene in nucleus
event
IMR:0001977
http://purl.org/obo/owl/IMR#IMR_0001977
Transcription by beta-catenin TCF complex (C. elegans)
event
OBSOLETE: remap to 'Transcription by beta-catenin TCF complex' IEV:0002282.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Activation of NLK by TAK1 in cytosol
event
IMR:0000232
http://purl.org/obo/owl/IMR#IMR_0000232
IMR:0001164
http://purl.org/obo/owl/IMR#IMR_0001164
Activation of APR-1 in cytosol
event
IMR:0001197
http://purl.org/obo/owl/IMR#IMR_0001197
Activation of APC in cytosol
event
IMR:0000205
http://purl.org/obo/owl/IMR#IMR_0000205
Activation of GSK3beta in cytosol
event
IMR:0100737
http://purl.org/obo/owl/IMR#IMR_0100737
Activation of SGG-1 in cytosol
event
IMR:0001246
http://purl.org/obo/owl/IMR#IMR_0001246
Binding of Notch1 and Delta1 in extracellular
event
IMR:0100720
http://purl.org/obo/owl/IMR#IMR_0100720
IMR:0100714
http://purl.org/obo/owl/IMR#IMR_0100714
Binding of Notch and Serrate/Jagged in extracellular
event
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
IMR:0001919
http://purl.org/obo/owl/IMR#IMR_0001919
Glycosylation of Notch by Fringe in cytosol
event
IMR:0001852
http://purl.org/obo/owl/IMR#IMR_0001852
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
Glycosylation
event
MI:0559
http://purl.org/obo/owl/MI#MI_0559
The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer. Reaction that can affect Ser, Thr, Cys, Arg, and Asn residues. This reaction is known to be reversible in the case of Asn substrate.
MI:0559
http://purl.org/obo/owl/MI#MI_0559
EC:2.4.-.-
http://purl.org/obo/owl/EC#EC_2.4.-.-
Glycosylation in cytosol
event
Binding of Notch (ICN) and Numb in cytosol
event
IMR:0001955
http://purl.org/obo/owl/IMR#IMR_0001955
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
Ubiquitination of Notch by Su(dx)/Itch in cytosol
event
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
IMR:0001943
http://purl.org/obo/owl/IMR#IMR_0001943
Notch degradation signaling
event
Phosphorylation of Notch (NIC) in cytosol
event
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
Ubiquitination of Notch (NIC) by SCF ubiquitin ligase complex including sel-10 in cytosol
event
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
IMR:0100470
http://purl.org/obo/owl/IMR#IMR_0100470
IMR:0001931
http://purl.org/obo/owl/IMR#IMR_0001931
Proteasome degradation of Notch (NIC) by 26S proteasome in cytosol
event
IMR:0000310
http://purl.org/obo/owl/IMR#IMR_0000310
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
Notch secretory pathway
event
Transcription of HES gene in nucleus
event
IMR:0001980
http://purl.org/obo/owl/IMR#IMR_0001980
Hedgehog signaling pathway
event
GO:0007224
http://purl.org/obo/owl/GO#GO_0007224
hh signaling pathway
GO:0007224
http://purl.org/obo/owl/GO#GO_0007224
smoothened signaling pathway
GO:0007224
http://purl.org/obo/owl/GO#GO_0007224
KEGG:hsa04340
http://purl.org/obo/owl/KEGG#KEGG_hsa04340
The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
GO:0007224
http://purl.org/obo/owl/GO#GO_0007224
Cleavage
event
MI:0194
http://purl.org/obo/owl/MI#MI_0194
Covalent bond breakage in a molecule leading to the formation of smaller molecules.
MI:0194
http://purl.org/obo/owl/MI#MI_0194
Autocleavage
event
Cholesterol modification
event
Cholesterol modification in ER
event
Autocleavage in ER
event
Secretory pathway of Hedgehog
event
Palmitoylation of hedgehog in ER
event
IMR:0000004
http://purl.org/obo/owl/IMR#IMR_0000004
Translocation of hedgehog from ER to plasma membrane
event
IMR:0000004
http://purl.org/obo/owl/IMR#IMR_0000004
Intercellular transport
event
GO:0010496
http://purl.org/obo/owl/GO#GO_0010496
The movement of substances between cells in a multicellular organism.
GO:0010496
http://purl.org/obo/owl/GO#GO_0010496
Cell-to-cell movement
cell-to-cell movement of Hedgehog
event
IMR:0000004
http://purl.org/obo/owl/IMR#IMR_0000004
Translocation of HSPG from Golgi to plasma membrane
event
IMR:0001125
http://purl.org/obo/owl/IMR#IMR_0001125
Translocation of Dlp/Dally from Golgi to plasma membrane
event
IMR:0002958
http://purl.org/obo/owl/IMR#IMR_0002958
Glycosylation of HSPG by Exostosin in cytosol
event
IMR:0001125
http://purl.org/obo/owl/IMR#IMR_0001125
IMR:0001396
http://purl.org/obo/owl/IMR#IMR_0001396
Glycosylation of Dlp/Dally by Tout-velu in cytosol
event
IMR:0002958
http://purl.org/obo/owl/IMR#IMR_0002958
IMR:0001392
http://purl.org/obo/owl/IMR#IMR_0001392
Activation of Smo
event
IMR:0100802
http://purl.org/obo/owl/IMR#IMR_0100802
Inactivation of Smo by Ptc in plasma membrane
event
IMR:0100802
http://purl.org/obo/owl/IMR#IMR_0100802
IMR:0000141
http://purl.org/obo/owl/IMR#IMR_0000141
Inactivation of Ptc by Hedgehog in extracellular
event
IMR:0000004
http://purl.org/obo/owl/IMR#IMR_0000004
IMR:0000141
http://purl.org/obo/owl/IMR#IMR_0000141
Binding of Ptc and Smo in plasma membrane
event
IMR:0100802
http://purl.org/obo/owl/IMR#IMR_0100802
IMR:0000141
http://purl.org/obo/owl/IMR#IMR_0000141
Binding of Hedgehog and Ptc in extracellular
event
IMR:0000004
http://purl.org/obo/owl/IMR#IMR_0000004
IMR:0000141
http://purl.org/obo/owl/IMR#IMR_0000141
Binding of Smo and Cos2:Fu:Ci/Gli in cytosol
event
IMR:0100807
http://purl.org/obo/owl/IMR#IMR_0100807
IMR:0001372
http://purl.org/obo/owl/IMR#IMR_0001372
IMR:0100802
http://purl.org/obo/owl/IMR#IMR_0100802
IMR:0100806
http://purl.org/obo/owl/IMR#IMR_0100806
Binding of Sufu and Ci/Gli in cytosol
event
IMR:0003011
http://purl.org/obo/owl/IMR#IMR_0003011
IMR:0001372
http://purl.org/obo/owl/IMR#IMR_0001372
Binding of Ci/Gli, Fu and Cos2 in cytosol
event
IMR:0100807
http://purl.org/obo/owl/IMR#IMR_0100807
IMR:0100806
http://purl.org/obo/owl/IMR#IMR_0100806
IMR:0001372
http://purl.org/obo/owl/IMR#IMR_0001372
Ci/Gli processing signaling
event
Phosphorylation of Ci/Gli by PKA in cytosol
event
IMR:0001372
http://purl.org/obo/owl/IMR#IMR_0001372
IMR:0000249
http://purl.org/obo/owl/IMR#IMR_0000249
Phosphorylation of Ci/Gli by CK1 in cytosol
event
IMR:0100809
http://purl.org/obo/owl/IMR#IMR_0100809
IMR:0001372
http://purl.org/obo/owl/IMR#IMR_0001372
Cell fate commitment
event
GO:0045165
http://purl.org/obo/owl/GO#GO_0045165
The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.
GO:0045165
http://purl.org/obo/owl/GO#GO_0045165
Phosphorylation of Ci/Gli by GSK3 in cytosol
event
IMR:0000257
http://purl.org/obo/owl/IMR#IMR_0000257
IMR:0001372
http://purl.org/obo/owl/IMR#IMR_0001372
Cleavage in cytosol
event
Cleavage of Ci/Gli in cytosol
event
IMR:0001372
http://purl.org/obo/owl/IMR#IMR_0001372
Nuclear import of Ci/Gli
event
IMR:0001372
http://purl.org/obo/owl/IMR#IMR_0001372
Nuclear import of Ci/GliR
event
IMR:0001372
http://purl.org/obo/owl/IMR#IMR_0001372
Transcription of Hh target gene in nucleus
event
IMR:0000004
http://purl.org/obo/owl/IMR#IMR_0000004
Transcription of ptc gene in nucleus
event
IMR:0000141
http://purl.org/obo/owl/IMR#IMR_0000141
Transcription of dpp gene in nucleus
event
IMR:0001981
http://purl.org/obo/owl/IMR#IMR_0001981
Cell-cell signaling involved in cell fate commitment
event
GO:0045168
http://purl.org/obo/owl/GO#GO_0045168
Signaling at long or short range between cells that results in the commitment of a cell to a certain fate.
GO:0045168
http://purl.org/obo/owl/GO#GO_0045168
Induction
event
GO:0031128
http://purl.org/obo/owl/GO#GO_0031128
Signaling at short range between cells or tissues of different ancestry and developmental potential that results in one cell or tissue effecting a developmental change in the other.
GO:0031128
http://purl.org/obo/owl/GO#GO_0031128
Lateral inhibition
event
Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells.
GO:0046331
http://purl.org/obo/owl/GO#GO_0046331
GO:0046331
http://purl.org/obo/owl/GO#GO_0046331
Cell-cell signaling
event
GO:0007267
http://purl.org/obo/owl/GO#GO_0007267
Any process that mediates the transfer of information from one cell to another.
GO:0007267
http://purl.org/obo/owl/GO#GO_0007267
Translocation from ER to Golgi
event
Translocation from Golgi to cytosol
event
Translocation from cytosol to Golgi
event
Translocation of Arrow/LRP5/6 from ER to Golgi
event
IMR:0002951
http://purl.org/obo/owl/IMR#IMR_0002951
Translocation of LRP6 from ER to Golgi
event
IMR:0000970
http://purl.org/obo/owl/IMR#IMR_0000970
Translocation of Arrow/LRP5/6 from Golgi to plasma membrane
event
IMR:0002951
http://purl.org/obo/owl/IMR#IMR_0002951
Translocation of LRP6 from Golgi to plasma membrane
event
IMR:0000970
http://purl.org/obo/owl/IMR#IMR_0000970
Binding of Notch and Serrate in extracellular
event
IMR:0001909
http://purl.org/obo/owl/IMR#IMR_0001909
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
Binding of Notch (ICN) and Deltex in cytosol
event
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
IMR:0001935
http://purl.org/obo/owl/IMR#IMR_0001935
Binding of Notch (ICN):CSL and Nrarp in inner space of nucleus
event
IMR:0100723
http://purl.org/obo/owl/IMR#IMR_0100723
IMR:0100712
http://purl.org/obo/owl/IMR#IMR_0100712
IMR:0001959
http://purl.org/obo/owl/IMR#IMR_0001959
Dissociation of Axin, APC, GSK3beta and beta-catenin
event
OBSOLETE: remap to 'Dissociation of Axin, APC, GSK3beta and beta-catenin in cytosol' IEV:0003870.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of EGFR and Grb2 in cytosol
event
IEV:0002445
IMR:0000340
http://purl.org/obo/owl/IMR#IMR_0000340
Binding of (GRB2:SOS) and (EGF:EGFR_p)
IMR:0000081
http://purl.org/obo/owl/IMR#IMR_0000081
Binding of EGFR and Shc in cytosol
event
IEV:0002443
IMR:0000081
http://purl.org/obo/owl/IMR#IMR_0000081
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
Binding of SHC and (EGF:EGFR_p)
Nuclear import of ERK1/2_p
event
IMR:0000227
http://purl.org/obo/owl/IMR#IMR_0000227
FGF receptor signaling pathway
event
FGF signaling pathway
GO:0008543
http://purl.org/obo/owl/GO#GO_0008543
FGFR signaling pathway
GO:0008543
http://purl.org/obo/owl/GO#GO_0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
GO:0008543
http://purl.org/obo/owl/GO#GO_0008543
fibroblast growth factor receptor signaling pathway
GO:0008543
http://purl.org/obo/owl/GO#GO_0008543
GO:0008543
http://purl.org/obo/owl/GO#GO_0008543
HGF receptor signaling pathway
event
HGFR signaling pathway
GO:0048012
http://purl.org/obo/owl/GO#GO_0048012
The series of molecular signals generated as a consequence of the hepatocyte growth factor receptor binding to one of its physiological ligands.
GO:0048012
http://purl.org/obo/owl/GO#GO_0048012
HGF signaling pathway
GO:0048012
http://purl.org/obo/owl/GO#GO_0048012
hepatocyte growth factor receptor signaling pathway
GO:0048012
http://purl.org/obo/owl/GO#GO_0048012
Binding of Met_p and Shc in cytosol
IEV:0002467
event
Binding of (HGF:Met_p) and Shc
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
IMR:0000071
http://purl.org/obo/owl/IMR#IMR_0000071
Binding of TRK and Shc in cytosol
event
IEV:0002473
Binding of SHC and (NGF:TRK_p)
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
IMR:0000072
http://purl.org/obo/owl/IMR#IMR_0000072
Binding of TRK and Grb2 in cytosol
event
IEV:0002475
Binding of (NGF:TRK_p) and (GRB2:SOS)
IMR:0000340
http://purl.org/obo/owl/IMR#IMR_0000340
IMR:0000072
http://purl.org/obo/owl/IMR#IMR_0000072
Phosphorylation of Shc by RTK in cytosol
event
IMR:0000063
http://purl.org/obo/owl/IMR#IMR_0000063
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
VEGF receptor signaling pathway
event
KEGG:hsa04370
http://purl.org/obo/owl/KEGG#KEGG_hsa04370
GO:0048010
http://purl.org/obo/owl/GO#GO_0048010
VEGF signaling pathway
GO:0048010
http://purl.org/obo/owl/GO#GO_0048010
vascular endothelial growth factor receptor signaling pathway
GO:0048010
http://purl.org/obo/owl/GO#GO_0048010
The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands.
GO:0048010
http://purl.org/obo/owl/GO#GO_0048010
Heterotrimeric GPCR signaling pathway (through Angiotensin and G alpha q)
event
Heterotrimeric GPCR signaling pathway (through G alpha q)
event
Heterotrimeric GPCR signaling pathway (through G alpha o)
event
Heterotrimeric GPCR signaling pathway (through G alpha t)
event
Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s)
event
Translation of antimicrobial protein in cytosol
event
IMR:0001815
http://purl.org/obo/owl/IMR#IMR_0001815
Translation of Defensin [Drosophila]
event
OBSOLETE: remap to 'Translation of Defensin' IEV:0003487.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Transcription of drosocin by Relish [Drosophila]
event
OBSOLETE: remap to 'Transcription of drosocin by Relish' IEV:0003482.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Translation of drosocin [Drosophila]
event
OBSOLETE: remap to 'Translation of drosocin' IEV:0003488.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Transcription of attacin by Relish [Drosophila]
event
OBSOLETE: remap to 'Transcription of attacin by Relish' IEV:0003476.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Translation of attacin [Drosophila]
event
OBSOLETE: remap to 'Translation of attacin' IEV:0003485.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Expression of cecropin by Relish
event
IMR:0001819
http://purl.org/obo/owl/IMR#IMR_0001819
Expression of cecropin by Relish [Drosophila]
IMR:0001814
http://purl.org/obo/owl/IMR#IMR_0001814
Transcription of cecropin by Relish [Drosophila]
event
OBSOLETE: remap to 'Transcription of cecropin by Relish' IEV:0003480.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Translation of cecropin [Drosophila]
event
OBSOLETE: remap to 'Translation of cecropin' IEV:0003486.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Transcription of diptericin by Relish [Drosophila]
event
OBSOLETE: remap to 'Transcription of diptericin by Relish' IEV:0003483.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Translation of diptericin [Drosophila]
event
OBSOLETE: remap to 'Translation of diptericin' IEV:0003489.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Transcription of drosomycin by Relish [Drosophila]
event
OBSOLETE: remap to 'Transcription of drosomycin by Relish' IEV:0003479.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Translation of drosomycin [Drosophila]
event
OBSOLETE: remap to 'Translation of drosomycin' IEV:0003484.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Activation of protein kinase by Pelle in cytosol
event
IMR:0000209
http://purl.org/obo/owl/IMR#IMR_0000209
IMR:0001802
http://purl.org/obo/owl/IMR#IMR_0001802
Activation in nucleus
event
Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta)
event
Transcription of antimicrobial peptide [Drosophila]
event
OBSOLETE: remap to 'Transcription of antimicrobial peptide' IEV:0003518.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of TPO receptor and JAK2 in cytosol
event
IMR:0000126
http://purl.org/obo/owl/IMR#IMR_0000126
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
Binding of TPO and TPO receptor and conformational change of receptors in plasma membrane
event
IMR:0000015
http://purl.org/obo/owl/IMR#IMR_0000015
IMR:0000126
http://purl.org/obo/owl/IMR#IMR_0000126
Phosphorylation of TPO receptor by JAK2 in cytosol
event
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
IMR:0000126
http://purl.org/obo/owl/IMR#IMR_0000126
Binding of TPO receptor and STAT3 in cytosol
event
IMR:0000126
http://purl.org/obo/owl/IMR#IMR_0000126
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
Phosphorylation of STAT3 by JAK2_p in cytosol
event
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
Dissociation of TPO receptor and STAT3 in cytosol
event
IMR:0000126
http://purl.org/obo/owl/IMR#IMR_0000126
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
Covalent binding
event
MI:0195
http://purl.org/obo/owl/MI#MI_0195
Interaction leading to the formation of covalent bond within an autocatalytic molecule or between partners.
MI:0195
http://purl.org/obo/owl/MI#MI_0195
Colocalization
event
MI:0403
http://purl.org/obo/owl/MI#MI_0403
PubMed:14755292
http://purl.org/obo/owl/PubMed#PubMed_14755292
co-occurrence of interactors in a limited subcellular location or similar distribution in various regions of a cell.
MI:0403
http://purl.org/obo/owl/MI#MI_0403
Disulfide binding
event
MI:0408
http://purl.org/obo/owl/MI#MI_0408
Covalent bond mediated by 2 sulfur atoms.
MI:0408
http://purl.org/obo/owl/MI#MI_0408
Transglutamination
event
MI:0566
http://purl.org/obo/owl/MI#MI_0566
Gln-Lys cross-link catalyzed by a transglutaminase.
MI:0556
http://purl.org/obo/owl/MI#MI_0556
DNA cleavage
event
Covalent bond breakage of a DNA molecule leading to the formation of smaller fragements.
MI:0572
http://purl.org/obo/owl/MI#MI_0572
MI:0572
http://purl.org/obo/owl/MI#MI_0572
lipid cleavage
event
MI:0212
http://purl.org/obo/owl/MI#MI_0212
Cleavage of a lipid group covalently bound to a protein residue.
MI:0212
http://purl.org/obo/owl/MI#MI_0212
Defarnesylation
event
MI:0198
http://purl.org/obo/owl/MI#MI_0198
S-farnesyl-L-cysteined is cleaved and returns a C residue.
MI:0198
http://purl.org/obo/owl/MI#MI_0198
Degeranylation
event
MI:0200
http://purl.org/obo/owl/MI#MI_0200
S-geranylgeranyl-L-cysteine is cleaved and returns a C residue.
MI:0200
http://purl.org/obo/owl/MI#MI_0200
Demyristoylation
event
N6-myristoyl-L-lysine is cleaved and returns a K residue.
MI:0201
http://purl.org/obo/owl/MI#MI_0201
MI:0201
http://purl.org/obo/owl/MI#MI_0201
Depalmitoylation
event
MI:0202
http://purl.org/obo/owl/MI#MI_0202
S-palmitoyl-L-cysteine, N6-palmitoyl-L-lysine, O-palmitoyl-L-threonine or O-palmitoyl-L-serine are cleaved and return C,K,T or S residues.
MI:0202
http://purl.org/obo/owl/MI#MI_0202
mRNA cleavage
event
MI:0571
http://purl.org/obo/owl/MI#MI_0571
Any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner.
MI:0571
http://purl.org/obo/owl/MI#MI_0571
Protein cleavage
event
MI:0570
http://purl.org/obo/owl/MI#MI_0570
Covalent modification of a polypeptide occuring during its maturation or its proteolytic degradation.
MI:0570
http://purl.org/obo/owl/MI#MI_0570
Deglycosylation
event
Reaction catalyzed by PNGase, a deglycosylating enzyme that promotes the hydrolysis of the beta-aspartylglycosylamine bond of aspargine-linked glycopeptides and glycoproteins.
MI:0558
http://purl.org/obo/owl/MI#MI_0558
MI:0558
http://purl.org/obo/owl/MI#MI_0558
Formylation
event
EC:2.1.2.3
http://purl.org/obo/owl/EC#EC_2.1.2.3
EC:2.1.2.2
http://purl.org/obo/owl/EC#EC_2.1.2.2
MI:0207
http://purl.org/obo/owl/MI#MI_0207
EC:2.1.2.9
http://purl.org/obo/owl/EC#EC_2.1.2.9
Reaction that can affect K or G residues.
MI:0207
http://purl.org/obo/owl/MI#MI_0207
Amidation
event
MI:0193
http://purl.org/obo/owl/MI#MI_0193
Irreversible reaction that can affect A,R,N,D,C,Q,E,G,H,I,L,K,M,F,P,S,T,W,Y or V residues.
MI:0193
http://purl.org/obo/owl/MI#MI_0193
EC:6.3.1.-
http://purl.org/obo/owl/EC#EC_6.3.1.-
Deformylation
event
MI:0199
http://purl.org/obo/owl/MI#MI_0199
N6-formyl-L-lysine is cleaved and returns a K residue.
MI:0199
http://purl.org/obo/owl/MI#MI_0199
Neddylation
event
MI:0567
http://purl.org/obo/owl/MI#MI_0567
Reversible reaction that create a covalent bond between a Glycine residue of an ubiquitine like NEDD8 protein and a lysine residue of the target.
MI:0567
http://purl.org/obo/owl/MI#MI_0567
Deneddylation
event
Cleavage of the G-K bond and release of the NEDD8 ubiquitin like proteins. Deneddylation, which removes the NEDD8 moiety, requires the isopeptidase activity of the COP9 signalosome.
MI:0569
http://purl.org/obo/owl/MI#MI_0569
MI:0569
http://purl.org/obo/owl/MI#MI_0569
Desumoylation
event
Cleavage of the G-K bond and release of the SUMO ubiquitin like proteins.
MI:0568
http://purl.org/obo/owl/MI#MI_0568
MI:0568
http://purl.org/obo/owl/MI#MI_0568
Deubiquitination
event
Cleavage of the G-K bond and release of ubiquitin or ubiquitin like proteins.
MI:0204
http://purl.org/obo/owl/MI#MI_0204
MI:0204
http://purl.org/obo/owl/MI#MI_0204
lipid addition
event
Covalent or non covalent binding of lipid group on a protein residue.
MI:0211
http://purl.org/obo/owl/MI#MI_0211
MI:0211
http://purl.org/obo/owl/MI#MI_0211
genetic interaction
event
Functional relationship among genes revealed by the phenotype of cells carrying combined mutations of those genes.
MI:0208
http://purl.org/obo/owl/MI#MI_0208
PubMed:14755292
http://purl.org/obo/owl/PubMed#PubMed_14755292
MI:0208
http://purl.org/obo/owl/MI#MI_0208
suppression
event
MI:0261
http://purl.org/obo/owl/MI#MI_0261
A supressed gene mutation cause of an altered phenotype that is reverted to wild type phenotype when cell also carry a suppressor gene with a specific mutation or altered expression level.nOBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796.
MI:0261
http://purl.org/obo/owl/MI#MI_0261
suppression expression alteration
event
MI:0265
http://purl.org/obo/owl/MI#MI_0265
An altered expression is the suppressor of a phenotype.nOBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'expression level alteration' MI:0803.
MI:0265
http://purl.org/obo/owl/MI#MI_0265
suppression overexpression
event
Overexpression is the suppressor of a phenotpe.nOBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'over expressed' MI:0506.
MI:0266
http://purl.org/obo/owl/MI#MI_0266
MI:0266
http://purl.org/obo/owl/MI#MI_0266
suppression underexpression
event
Underexpression is the suppressor of a phenotype.nOBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'under expressed' MI:0223.
MI:0268
http://purl.org/obo/owl/MI#MI_0268
MI:0268
http://purl.org/obo/owl/MI#MI_0268
suppression mutation
event
MI:0262
http://purl.org/obo/owl/MI#MI_0262
a given (suppressed) mutation phenotype is reverted by a supressor gene mutation.nOBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'mutated gene' MI:0804.
MI:0262
http://purl.org/obo/owl/MI#MI_0262
suppression knockout
event
Knocked out gene is the suppressor of a phenotype.nOBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'knock out' MI:0788.
MI:0263
http://purl.org/obo/owl/MI#MI_0263
MI:0263
http://purl.org/obo/owl/MI#MI_0263
suppression partial alteration
event
MI:0264
http://purl.org/obo/owl/MI#MI_0264
A mutation is the partial suppressor of a mutant phenotype.nOBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'knock down' MI:0789.
MI:0264
http://purl.org/obo/owl/MI#MI_0264
synthetic phenotype
event
Two silent mutations show an altered phenotype when they co-occur on the same cell.nOBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794.
MI:0269
http://purl.org/obo/owl/MI#MI_0269
MI:0269
http://purl.org/obo/owl/MI#MI_0269
synthetic lethal
event
Death phenotype observed on cells carrying combination of two independently silent mutations.nOBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description (lethal FBcv:0000351)
MI:0219
http://purl.org/obo/owl/MI#MI_0219
MI:0219
http://purl.org/obo/owl/MI#MI_0219
synthetic growth effect
event
Two silent mutations show altered growth effect when they co-occur on the same cell. nOBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description ( FBcv:0000427 'cell growth defective')
MI:0273
http://purl.org/obo/owl/MI#MI_0273
MI:0273
http://purl.org/obo/owl/MI#MI_0273
conditional synthetic lethal
event
Two silent mutations show a conditional synthetic lethal phenotype when they co-occur on the same cell. nOBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description (lethal FBcv:0000351)
MI:0270
http://purl.org/obo/owl/MI#MI_0270
MI:0270
http://purl.org/obo/owl/MI#MI_0270
suppression scalable
event
Level of over/underexpression scales the 'extend' of a phenotype.nOBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'expression level alteration' MI:0803.
MI:0267
http://purl.org/obo/owl/MI#MI_0267
MI:0267
http://purl.org/obo/owl/MI#MI_0267
conditional synthetic lethal nutrition-sensitivity
event
Two silent mutations show a nutrition sensitive lethal phenotype when they co-occur on the same cell.nOBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description.
MI:0600
http://purl.org/obo/owl/MI#MI_0600
MI:0600
http://purl.org/obo/owl/MI#MI_0600
conditional synthetic lethal temperature-sensitivity
event
MI:0271
http://purl.org/obo/owl/MI#MI_0271
Two silent mutations show a temperature sensitive lethal phenotype when they co-occur on the same cell.nOBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description (FBcv:0000310 'temperature conditional')
MI:0271
http://purl.org/obo/owl/MI#MI_0271
synthetic growth defect
event
Two silent mutations show growth defect when they co-occur on the same cell. nOBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description ( FBcv:0000427 'cell growth defective')
MI:0274
http://purl.org/obo/owl/MI#MI_0274
MI:0274
http://purl.org/obo/owl/MI#MI_0274
synthetic growth increase
event
MI:0275
http://purl.org/obo/owl/MI#MI_0275
Two silent mutations show growth increase when they co-occur on the same cell. nOBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description ( FBcv:0000427 'cell growth defective')
MI:0275
http://purl.org/obo/owl/MI#MI_0275
Nervous System Malformation
event
Structural abnormalities of the central or peripheral nervous system resulting primarily from defects of embryogenesis.
MeSH:D009421
http://purl.org/obo/owl/MeSH#MeSH_D009421
MeSH:D009421
http://purl.org/obo/owl/MeSH#MeSH_D009421
Neural Tube Defect
event
MeSH:D009436
http://purl.org/obo/owl/MeSH#MeSH_D009436
Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure.
MeSH:D009436
http://purl.org/obo/owl/MeSH#MeSH_D009436
Nervous System Disease
event
MeSH:D009422
http://purl.org/obo/owl/MeSH#MeSH_D009422
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
MeSH:D009422
http://purl.org/obo/owl/MeSH#MeSH_D009422
Spinal Dysraphism
event
PubMed:15555669
http://purl.org/obo/owl/PubMed#PubMed_15555669
MeSH:D016135
http://purl.org/obo/owl/MeSH#MeSH_D016135
Congenital defects of closure of one or more vertebral arches, which may be associated with malformations of the spinal cord, nerve roots, congenital fibrous bands, lipomas, and congenital cysts. These malformations range from mild (e.g., SPINA BIFIDA OCCULTA) to severe, including rachischisis where there is complete failure of neural tube and spinal cord fusion, resulting in exposure of the spinal cord at the surface. Spinal dysraphism includes all forms of spina bifida. The open form is called SPINA BIFIDA CYSTICA and the closed form is SPINA BIFIDA OCCULTA.
MeSH:D016135
http://purl.org/obo/owl/MeSH#MeSH_D016135
Phosphorylation of MKK4 by MEKK4 in cytosol
event
UniProt:Q9Y6R4
http://purl.org/obo/owl/UniProt#UniProt_Q9Y6R4
PubMed:15731347
http://purl.org/obo/owl/PubMed#PubMed_15731347
IMR:0100454
http://purl.org/obo/owl/IMR#IMR_0100454
Morphogenesis of embryonic epithelium
event
GO:0016331
http://purl.org/obo/owl/GO#GO_0016331
The process by which the anatomical structures of embryonic epithelia are generated and organized. Morphogenesis pertains to the creation of form.
GO:0016331
http://purl.org/obo/owl/GO#GO_0016331
Embryonic epithelial tube formation
event
The morphogenesis of an embryonic epithelium into a tube-shaped structure.
GO:0001838
http://purl.org/obo/owl/GO#GO_0001838
GO:0001838
http://purl.org/obo/owl/GO#GO_0001838
Morphogenesis of an epithelium
event
The process by which the anatomical structures of epithelia are generated and organized. Morphogenesis pertains to the creation of form. An epithelium is a sheet of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.
GO:0002009
http://purl.org/obo/owl/GO#GO_0002009
GO:0002009
http://purl.org/obo/owl/GO#GO_0002009
Neural tube formation
event
neural tube morphogenesis
neurulation
GO:0001841
http://purl.org/obo/owl/GO#GO_0001841
The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
GO:0001841
http://purl.org/obo/owl/GO#GO_0001841
GO:0001841
http://purl.org/obo/owl/GO#GO_0001841
Neural tube closure
event
GO:0001843
http://purl.org/obo/owl/GO#GO_0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together at the dorsal midline.
GO:0001843
http://purl.org/obo/owl/GO#GO_0001843
Neural plate morphogenesis
event
GO:0001839
http://purl.org/obo/owl/GO#GO_0001839
The process by which the anatomical structures of the neural plate are generated and organized. Morphogenesis pertains to the creation of form. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue.
GO:0001839
http://purl.org/obo/owl/GO#GO_0001839
Nervous system development
event
GO:0007399
http://purl.org/obo/owl/GO#GO_0007399
neurite formation
GO:0007399
http://purl.org/obo/owl/GO#GO_0007399
The origin and formation of nervous tissue.
GO:0007399
http://purl.org/obo/owl/GO#GO_0007399
neurite growth
GO:0007399
http://purl.org/obo/owl/GO#GO_0007399
Tube morphogenesis
event
GO:0035239
http://purl.org/obo/owl/GO#GO_0035239
The process by which the anatomical structures of a tube are generated and organized. Morphogenesis pertains to the creation of form. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
GO:0035239
http://purl.org/obo/owl/GO#GO_0035239
Organ development
event
organogenesis
GO:0048513
http://purl.org/obo/owl/GO#GO_0048513
development of an organ
GO:0048513
http://purl.org/obo/owl/GO#GO_0048513
GO:0048513
http://purl.org/obo/owl/GO#GO_0048513
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
GO:0048513
http://purl.org/obo/owl/GO#GO_0048513
Tube development
event
The process whose specific outcome is the progression of a tube over time, from its intial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.
GO:0035295
http://purl.org/obo/owl/GO#GO_0035295
GO:0035295
http://purl.org/obo/owl/GO#GO_0035295
Toll-like receptor signaling pathway (through JNK cascade)
event
Binding of ECSIT and MEKK1 in cytosol
event
IMR:0100222
http://purl.org/obo/owl/IMR#IMR_0100222
IMR:0100539
http://purl.org/obo/owl/IMR#IMR_0100539
Binding of TRAF6 and ECSIT in cytosol
event
IMR:0100427
http://purl.org/obo/owl/IMR#IMR_0100427
IMR:0100539
http://purl.org/obo/owl/IMR#IMR_0100539
Binding of cytokine receptor and Grb2 in cytosol
event
IMR:0000340
http://purl.org/obo/owl/IMR#IMR_0000340
IMR:0000095
http://purl.org/obo/owl/IMR#IMR_0000095
Dephosphorylation of STAT5 by SHP-2 in cytosol
event
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
IMR:0000276
http://purl.org/obo/owl/IMR#IMR_0000276
Phosphorylation of STAT3 dimer by serine kinase in cytosol and/or nucleus
event
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
IMR:0000223
http://purl.org/obo/owl/IMR#IMR_0000223
nonenzymatic reaction
event
The reaction direction shown, that is, A + B <==> C + D versus C + D <==> A + B, is in accordance with the direction of the reaction within a pathway.nThis reaction occurs spontaneously -- no enzyme is required.
EcoCyc:NULL
http://purl.org/obo/owl/EcoCyc#EcoCyc_NULL
enzymatic reaction
event
Terms aiming to represent biochemical reactions referring to their resulting product modifications.
MI:0414
http://purl.org/obo/owl/MI#MI_0414
MI:0414
http://purl.org/obo/owl/MI#MI_0414
Alcohol + NAD+ = Aldehyde + NADH + H+( EC:1.1.1.1 )
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+( EC:1.1.1.1 )
event
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:C00069
http://purl.org/obo/owl/KEGG#KEGG_C00069
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
EC:1.1.1.1
http://purl.org/obo/owl/EC#EC_1.1.1.1
KEGG:R07326
http://purl.org/obo/owl/KEGG#KEGG_R07326
KEGG:C00071
http://purl.org/obo/owl/KEGG#KEGG_C00071
Secondary alcohol + NADP+ = Ketone + NADPH + H+( EC:1.1.1.184 )
event
KEGG:C01450
http://purl.org/obo/owl/KEGG#KEGG_C01450
KEGG:C01612
http://purl.org/obo/owl/KEGG#KEGG_C01612
KEGG:R03557
http://purl.org/obo/owl/KEGG#KEGG_R03557
EC:1.1.1.184
http://purl.org/obo/owl/EC#EC_1.1.1.184
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
Alditol + NADP+ = Aldose + NADPH + H+( EC:1.1.1.21 )
event
KEGG:R02820
http://purl.org/obo/owl/KEGG#KEGG_R02820
KEGG:C01370
http://purl.org/obo/owl/KEGG#KEGG_C01370
KEGG:C00717
http://purl.org/obo/owl/KEGG#KEGG_C00717
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.1.1.21
http://purl.org/obo/owl/EC#EC_1.1.1.21
(3S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+( EC:1.1.1.35 )
event
KEGG:C00264
http://purl.org/obo/owl/KEGG#KEGG_C00264
KEGG:C00640
http://purl.org/obo/owl/KEGG#KEGG_C00640
KEGG:R01778
http://purl.org/obo/owl/KEGG#KEGG_R01778
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
EC:1.1.1.35
http://purl.org/obo/owl/EC#EC_1.1.1.35
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
procollagen L-proline + 2-Oxo-glutaric acid + O2 = procollagen trans-4-hydroxy-L-proline + Succinic acid + CO2( EC:1.14.11.2 )
event
EC:1.14.11.2
http://purl.org/obo/owl/EC#EC_1.14.11.2
IMR:0200119
http://purl.org/obo/owl/IMR#IMR_0200119
KEGG:R03219
http://purl.org/obo/owl/KEGG#KEGG_R03219
KEGG:C04398
http://purl.org/obo/owl/KEGG#KEGG_C04398
KEGG:C01078
http://purl.org/obo/owl/KEGG#KEGG_C01078
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
Alkane + Reduced flavoprotein + O2 = ROH + Oxidized flavoprotein + H2O( EC:1.14.14.1 )
event
KEGG:C01371
http://purl.org/obo/owl/KEGG#KEGG_C01371
KEGG:R04122
http://purl.org/obo/owl/KEGG#KEGG_R04122
IMR:0200519
http://purl.org/obo/owl/IMR#IMR_0200519
KEGG:C01335
http://purl.org/obo/owl/KEGG#KEGG_C01335
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200450
http://purl.org/obo/owl/IMR#IMR_0200450
EC:1.14.14.1
http://purl.org/obo/owl/EC#EC_1.14.14.1
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin( EC:1.17.4.1 )
event
KEGG:C04232
http://purl.org/obo/owl/KEGG#KEGG_C04232
KEGG:R04294
http://purl.org/obo/owl/KEGG#KEGG_R04294
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:C03723
http://purl.org/obo/owl/KEGG#KEGG_C03723
IMR:0200108
http://purl.org/obo/owl/IMR#IMR_0200108
IMR:0200133
http://purl.org/obo/owl/IMR#IMR_0200133
EC:1.17.4.1
http://purl.org/obo/owl/EC#EC_1.17.4.1
Aldehyde + NAD+ + H2O = Carboxylate + NADH + H+( EC:1.2.1.3 )
event
KEGG:C00071
http://purl.org/obo/owl/KEGG#KEGG_C00071
KEGG:R00538
http://purl.org/obo/owl/KEGG#KEGG_R00538
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.2.1.3
http://purl.org/obo/owl/EC#EC_1.2.1.3
KEGG:C00060
http://purl.org/obo/owl/KEGG#KEGG_C00060
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
Aldehyde + NADP+ + H2O = Carboxylate + NADPH + H+( EC:1.2.1.5 )
event
KEGG:C00060
http://purl.org/obo/owl/KEGG#KEGG_C00060
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.2.1.5
http://purl.org/obo/owl/EC#EC_1.2.1.5
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
KEGG:C00071
http://purl.org/obo/owl/KEGG#KEGG_C00071
KEGG:R00634
http://purl.org/obo/owl/KEGG#KEGG_R00634
Aldehyde + H2O + O2 = Carboxylate + H2O2( EC:1.2.3.1 )
event
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
EC:1.2.3.1
http://purl.org/obo/owl/EC#EC_1.2.3.1
KEGG:R00635
http://purl.org/obo/owl/KEGG#KEGG_R00635
KEGG:C00060
http://purl.org/obo/owl/KEGG#KEGG_C00060
KEGG:C00071
http://purl.org/obo/owl/KEGG#KEGG_C00071
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
Acyl-CoA + Acceptor = 2,3-dehydroacyl-CoA + Reduced acceptor( EC:1.3.99.3 )
event
KEGG:C00605
http://purl.org/obo/owl/KEGG#KEGG_C00605
IMR:0200300
http://purl.org/obo/owl/IMR#IMR_0200300
IMR:0200224
http://purl.org/obo/owl/IMR#IMR_0200224
IMR:0200065
http://purl.org/obo/owl/IMR#IMR_0200065
KEGG:R00392
http://purl.org/obo/owl/KEGG#KEGG_R00392
EC:1.3.99.3
http://purl.org/obo/owl/EC#EC_1.3.99.3
D-amino acid + H2O + O2 = 2-oxo acid + NH3 + H2O2( EC:1.4.3.3 )
event
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
EC:1.4.3.3
http://purl.org/obo/owl/EC#EC_1.4.3.3
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
KEGG:R01340
http://purl.org/obo/owl/KEGG#KEGG_R01340
KEGG:C00405
http://purl.org/obo/owl/KEGG#KEGG_C00405
KEGG:C00161
http://purl.org/obo/owl/KEGG#KEGG_C00161
Primary amine + H2O + O2 = Aldehyde + NH3 + H2O2( EC:1.4.3.4 )
event
KEGG:R01853
http://purl.org/obo/owl/KEGG#KEGG_R01853
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
EC:1.4.3.4
http://purl.org/obo/owl/EC#EC_1.4.3.4
KEGG:C00375
http://purl.org/obo/owl/KEGG#KEGG_C00375
KEGG:C00071
http://purl.org/obo/owl/KEGG#KEGG_C00071
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
Primary amine + H2O + O2 = Aldehyde + NH3 + H2O2( EC:1.4.3.21 )
event
KEGG:R01853
http://purl.org/obo/owl/KEGG#KEGG_R01853
KEGG:C00375
http://purl.org/obo/owl/KEGG#KEGG_C00375
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
KEGG:C00071
http://purl.org/obo/owl/KEGG#KEGG_C00071
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
EC:1.4.3.21
http://purl.org/obo/owl/EC#EC_1.4.3.21
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+( EC:1.8.1.4 )
event
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
KEGG:R08550
http://purl.org/obo/owl/KEGG#KEGG_R08550
KEGG:C16832
http://purl.org/obo/owl/KEGG#KEGG_C16832
KEGG:C16237
http://purl.org/obo/owl/KEGG#KEGG_C16237
EC:1.8.1.4
http://purl.org/obo/owl/EC#EC_1.8.1.4
S-adenosyl-L-methionine + Amine = S-adenosyl-L-homocysteine + Methylated amine( EC:2.1.1.49 )
event
KEGG:C02436
http://purl.org/obo/owl/KEGG#KEGG_C02436
KEGG:R02808
http://purl.org/obo/owl/KEGG#KEGG_R02808
EC:2.1.1.49
http://purl.org/obo/owl/EC#EC_2.1.1.49
IMR:0200054
http://purl.org/obo/owl/IMR#IMR_0200054
IMR:0200151
http://purl.org/obo/owl/IMR#IMR_0200151
KEGG:C00706
http://purl.org/obo/owl/KEGG#KEGG_C00706
Acyl-CoA + Acetyl-CoA = CoA + 3-Oxoacyl-CoA( EC:2.3.1.16 )
event
KEGG:R00391
http://purl.org/obo/owl/KEGG#KEGG_R00391
IMR:0200414
http://purl.org/obo/owl/IMR#IMR_0200414
KEGG:C00264
http://purl.org/obo/owl/KEGG#KEGG_C00264
IMR:0200065
http://purl.org/obo/owl/IMR#IMR_0200065
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
EC:2.3.1.16
http://purl.org/obo/owl/EC#EC_2.3.1.16
(5-L-glutamyl)-peptide + Amino acid = peptide + 5-L-glutamyl amino acid( EC:2.3.2.2 )
event
KEGG:C03363
http://purl.org/obo/owl/KEGG#KEGG_C03363
KEGG:C03193
http://purl.org/obo/owl/KEGG#KEGG_C03193
KEGG:C00012
http://purl.org/obo/owl/KEGG#KEGG_C00012
EC:2.3.2.2
http://purl.org/obo/owl/EC#EC_2.3.2.2
IMR:0001695
http://purl.org/obo/owl/IMR#IMR_0001695
KEGG:R04159
http://purl.org/obo/owl/KEGG#KEGG_R04159
purine nucleoside + Orthophosphate = purine + D-ribose 1-phosphate( EC:2.4.2.1 )
general reaction
event
KEGG:C15587
http://purl.org/obo/owl/KEGG#KEGG_C15587
KEGG:R08368
http://purl.org/obo/owl/KEGG#KEGG_R08368
KEGG:C00620
http://purl.org/obo/owl/KEGG#KEGG_C00620
KEGG:C15586
http://purl.org/obo/owl/KEGG#KEGG_C15586
EC:2.4.2.1
http://purl.org/obo/owl/EC#EC_2.4.2.1
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
Phosphoenol-pyruvic acid + N-acyl-D-mannosamine 6-phosphate + H2O = N-acylneuraminate 9-phosphate + Orthophosphate( EC:2.5.1.57 )
event
KEGG:C01200
http://purl.org/obo/owl/KEGG#KEGG_C01200
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
EC:2.5.1.57
http://purl.org/obo/owl/EC#EC_2.5.1.57
KEGG:C00686
http://purl.org/obo/owl/KEGG#KEGG_C00686
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200223
http://purl.org/obo/owl/IMR#IMR_0200223
KEGG:R02769
http://purl.org/obo/owl/KEGG#KEGG_R02769
ATP + D-hexose = ADP + D-hexose 6-phosphate( EC:2.7.1.1 )
event
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:2.7.1.1
http://purl.org/obo/owl/EC#EC_2.7.1.1
KEGG:C00738
http://purl.org/obo/owl/KEGG#KEGG_C00738
KEGG:C02965
http://purl.org/obo/owl/KEGG#KEGG_C02965
KEGG:R02848
http://purl.org/obo/owl/KEGG#KEGG_R02848
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate( EC:2.7.1.60 )
event
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:2.7.1.60
http://purl.org/obo/owl/EC#EC_2.7.1.60
KEGG:C00625
http://purl.org/obo/owl/KEGG#KEGG_C00625
KEGG:C00686
http://purl.org/obo/owl/KEGG#KEGG_C00686
KEGG:R02650
http://purl.org/obo/owl/KEGG#KEGG_R02650
Nucleoside triphosphate + deoxycytidine = Nucleoside diphosphate + dCMP( EC:2.7.1.74 )
event
EC:2.7.1.74
http://purl.org/obo/owl/EC#EC_2.7.1.74
IMR:0200499
http://purl.org/obo/owl/IMR#IMR_0200499
KEGG:C00454
http://purl.org/obo/owl/KEGG#KEGG_C00454
KEGG:R02321
http://purl.org/obo/owl/KEGG#KEGG_R02321
IMR:0200005
http://purl.org/obo/owl/IMR#IMR_0200005
IMR:0200390
http://purl.org/obo/owl/IMR#IMR_0200390
Nucleoside triphosphate + AMP = Nucleoside diphosphate + ADP( EC:2.7.4.10 )
event
KEGG:C00454
http://purl.org/obo/owl/KEGG#KEGG_C00454
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0200499
http://purl.org/obo/owl/IMR#IMR_0200499
EC:2.7.4.10
http://purl.org/obo/owl/EC#EC_2.7.4.10
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
KEGG:R00333
http://purl.org/obo/owl/KEGG#KEGG_R00333
CTP + N-acylneuraminate = Pyrophosphate + CMP-N-acylneuraminate( EC:2.7.7.43 )
event
EC:2.7.7.43
http://purl.org/obo/owl/EC#EC_2.7.7.43
IMR:0200202
http://purl.org/obo/owl/IMR#IMR_0200202
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
KEGG:C00591
http://purl.org/obo/owl/KEGG#KEGG_C00591
KEGG:C01064
http://purl.org/obo/owl/KEGG#KEGG_C01064
KEGG:R02599
http://purl.org/obo/owl/KEGG#KEGG_R02599
Succinyl-CoA + 3-oxo acid = succinate + 3-oxoacyl-CoA( EC:2.8.3.5 )
event
KEGG:R01780
http://purl.org/obo/owl/KEGG#KEGG_R01780
KEGG:C01656
http://purl.org/obo/owl/KEGG#KEGG_C01656
KEGG:C00264
http://purl.org/obo/owl/KEGG#KEGG_C00264
IMR:0200037
http://purl.org/obo/owl/IMR#IMR_0200037
IMR:0200119
http://purl.org/obo/owl/IMR#IMR_0200119
EC:2.8.3.5
http://purl.org/obo/owl/EC#EC_2.8.3.5
myo-inositol phosphate + H2O = myo-inositol + Orthophosphate( EC:3.1.3.25 )
event
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
EC:3.1.3.25
http://purl.org/obo/owl/EC#EC_3.1.3.25
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200177
http://purl.org/obo/owl/IMR#IMR_0200177
KEGG:R07343
http://purl.org/obo/owl/KEGG#KEGG_R07343
KEGG:C15585
http://purl.org/obo/owl/KEGG#KEGG_C15585
5'-ribonucleotide + H2O = ribonucleoside + phosphate( EC:3.1.3.5 )
event
EC:3.1.3.5
http://purl.org/obo/owl/EC#EC_3.1.3.5
KEGG:C00911
http://purl.org/obo/owl/KEGG#KEGG_C00911
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
KEGG:R07297
http://purl.org/obo/owl/KEGG#KEGG_R07297
KEGG:C02520
http://purl.org/obo/owl/KEGG#KEGG_C02520
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate( EC:3.1.4.17 )
event
KEGG:C01117
http://purl.org/obo/owl/KEGG#KEGG_C01117
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:R03259
http://purl.org/obo/owl/KEGG#KEGG_R03259
KEGG:C04212
http://purl.org/obo/owl/KEGG#KEGG_C04212
EC:3.1.4.17
http://purl.org/obo/owl/EC#EC_3.1.4.17
Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides( EC:3.2.1.23 )
event
EC:3.2.1.23
http://purl.org/obo/owl/EC#EC_3.2.1.23
N-acyl-L-aspartate + H2O = Carboxylate + L-Aspartic acid( EC:3.5.1.15 )
event
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
EC:3.5.1.15
http://purl.org/obo/owl/EC#EC_3.5.1.15
KEGG:C00060
http://purl.org/obo/owl/KEGG#KEGG_C00060
IMR:0200459
http://purl.org/obo/owl/IMR#IMR_0200459
KEGG:R00546
http://purl.org/obo/owl/KEGG#KEGG_R00546
KEGG:C02715
http://purl.org/obo/owl/KEGG#KEGG_C02715
Nucleoside triphosphate + H2O = Nucleotide + diphosphate( EC:3.6.1.19 )
event
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200499
http://purl.org/obo/owl/IMR#IMR_0200499
KEGG:R01532
http://purl.org/obo/owl/KEGG#KEGG_R01532
EC:3.6.1.19
http://purl.org/obo/owl/EC#EC_3.6.1.19
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0001349
http://purl.org/obo/owl/IMR#IMR_0001349
nucleoside diphosphate + H2O = nucleotide + Orthophosphate( EC:3.6.1.6 )
event
KEGG:C00454
http://purl.org/obo/owl/KEGG#KEGG_C00454
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0001349
http://purl.org/obo/owl/IMR#IMR_0001349
KEGG:R00329
http://purl.org/obo/owl/KEGG#KEGG_R00329
EC:3.6.1.6
http://purl.org/obo/owl/EC#EC_3.6.1.6
Acylphosphate + H2O = Carboxylate + phosphate( EC:3.6.1.7 )
event
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
KEGG:C02133
http://purl.org/obo/owl/KEGG#KEGG_C02133
KEGG:C00060
http://purl.org/obo/owl/KEGG#KEGG_C00060
KEGG:R00539
http://purl.org/obo/owl/KEGG#KEGG_R00539
EC:3.6.1.7
http://purl.org/obo/owl/EC#EC_3.6.1.7
dinucleotide + H2O = 2 mononucleotide( EC:3.6.1.9 )
event
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
EC:3.6.1.9
http://purl.org/obo/owl/EC#EC_3.6.1.9
KEGG:C02171
http://purl.org/obo/owl/KEGG#KEGG_C02171
KEGG:C01910
http://purl.org/obo/owl/KEGG#KEGG_C01910
KEGG:R00056
http://purl.org/obo/owl/KEGG#KEGG_R00056
(3S)-3-hydroxyacyl-CoA = trans-2,3-Dehydroacyl-CoA + H2O( EC:4.2.1.17 )
event
EC:4.2.1.17
http://purl.org/obo/owl/EC#EC_4.2.1.17
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:C00658
http://purl.org/obo/owl/KEGG#KEGG_C00658
KEGG:C00640
http://purl.org/obo/owl/KEGG#KEGG_C00640
KEGG:R02685
http://purl.org/obo/owl/KEGG#KEGG_R02685
N-acyl-D-glucosamine = N-acyl-D-mannosamine( EC:5.1.3.8 )
event
KEGG:C03000
http://purl.org/obo/owl/KEGG#KEGG_C03000
KEGG:R02652
http://purl.org/obo/owl/KEGG#KEGG_R02652
EC:5.1.3.8
http://purl.org/obo/owl/EC#EC_5.1.3.8
KEGG:C00625
http://purl.org/obo/owl/KEGG#KEGG_C00625
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine( EC:3.4.13.20 )
event
EC:3.4.13.20
http://purl.org/obo/owl/EC#EC_3.4.13.20
Pyruvic acid + Enzyme N6-(lipoyl)lysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2( EC:1.2.4.1 )
pyruvate + [dihydrolipoyllysine-residue acetyltransferase]lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2( EC:1.2.4.1 )
event
KEGG:R01699
http://purl.org/obo/owl/KEGG#KEGG_R01699
KEGG:C16255
http://purl.org/obo/owl/KEGG#KEGG_C16255
KEGG:C15972
http://purl.org/obo/owl/KEGG#KEGG_C15972
IMR:0200331
http://purl.org/obo/owl/IMR#IMR_0200331
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
EC:1.2.4.1
http://purl.org/obo/owl/EC#EC_1.2.4.1
2-Oxo-glutaric acid + Enzyme N6-(lipoyl)lysine = [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2( EC:1.2.4.2 )
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2( EC:1.2.4.2 )
event
EC:1.2.4.2
http://purl.org/obo/owl/EC#EC_1.2.4.2
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
KEGG:R01700
http://purl.org/obo/owl/KEGG#KEGG_R01700
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
KEGG:C16254
http://purl.org/obo/owl/KEGG#KEGG_C16254
KEGG:C15972
http://purl.org/obo/owl/KEGG#KEGG_C15972
ATP + Uridine => ADP + UMP( EC:2.7.1.48 )
event
KEGG:R00964
http://purl.org/obo/owl/KEGG#KEGG_R00964
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:2.7.1.48
http://purl.org/obo/owl/EC#EC_2.7.1.48
IMR:0200021
http://purl.org/obo/owl/IMR#IMR_0200021
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0200409
http://purl.org/obo/owl/IMR#IMR_0200409
ATP + D-Ribose 5-phosphate = AMP + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.7.6.1 )
ATP + D-Ribose 5-phosphate = AMP + D-5-Phospho-ribosyl 1-diphosphate( EC:2.7.6.1 )
event
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:2.7.6.1
http://purl.org/obo/owl/EC#EC_2.7.6.1
KEGG:map00030
http://purl.org/obo/owl/KEGG#KEGG_map00030
IMR:0200179
http://purl.org/obo/owl/IMR#IMR_0200179
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0200060
http://purl.org/obo/owl/IMR#IMR_0200060
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R01049
http://purl.org/obo/owl/KEGG#KEGG_R01049
2-Oxo-glutaric acid + beta-Alanine = L-Glutamic acid + Malonate semialdehyde( EC:2.6.1.19 )
event
IMR:0200520
http://purl.org/obo/owl/IMR#IMR_0200520
KEGG:map00410
http://purl.org/obo/owl/KEGG#KEGG_map00410
IMR:0200438
http://purl.org/obo/owl/IMR#IMR_0200438
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
EC:2.6.1.19
http://purl.org/obo/owl/EC#EC_2.6.1.19
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
KEGG:map00640
http://purl.org/obo/owl/KEGG#KEGG_map00640
KEGG:R00908
http://purl.org/obo/owl/KEGG#KEGG_R00908
L-Arginine + Glycine = L-Ornithine + Guanidino-acetic acid( EC:2.1.4.1 )
event
KEGG:R00565
http://purl.org/obo/owl/KEGG#KEGG_R00565
IMR:0200428
http://purl.org/obo/owl/IMR#IMR_0200428
IMR:0200413
http://purl.org/obo/owl/IMR#IMR_0200413
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
EC:2.1.4.1
http://purl.org/obo/owl/EC#EC_2.1.4.1
IMR:0200342
http://purl.org/obo/owl/IMR#IMR_0200342
IMR:0100118
http://purl.org/obo/owl/IMR#IMR_0100118
L-Arginino-succinic acid = L-Arginine + Fumaric acid( EC:4.3.2.1 )
event
EC:4.3.2.1
http://purl.org/obo/owl/EC#EC_4.3.2.1
IMR:0200186
http://purl.org/obo/owl/IMR#IMR_0200186
IMR:0200391
http://purl.org/obo/owl/IMR#IMR_0200391
IMR:0200428
http://purl.org/obo/owl/IMR#IMR_0200428
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
KEGG:R01086
http://purl.org/obo/owl/KEGG#KEGG_R01086
ATP + D-Ribose => ADP + D-Ribose 5-phosphate( EC:2.7.1.15 )
event
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200060
http://purl.org/obo/owl/IMR#IMR_0200060
EC:2.7.1.15
http://purl.org/obo/owl/EC#EC_2.7.1.15
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
KEGG:R01051
http://purl.org/obo/owl/KEGG#KEGG_R01051
IMR:0200130
http://purl.org/obo/owl/IMR#IMR_0200130
KEGG:map00030
http://purl.org/obo/owl/KEGG#KEGG_map00030
NAD+ + D-Sorbitol = NADH + D-Fructose + H+( EC:1.1.1.14 )
NAD+ + D-Sorbitol = NADH + D-Fructose( EC:1.1.1.14 )
event
KEGG:R00875
http://purl.org/obo/owl/KEGG#KEGG_R00875
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:map00051
http://purl.org/obo/owl/KEGG#KEGG_map00051
EC:1.1.1.14
http://purl.org/obo/owl/EC#EC_1.1.1.14
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200474
http://purl.org/obo/owl/IMR#IMR_0200474
IMR:0200462
http://purl.org/obo/owl/IMR#IMR_0200462
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
2 Farnesyl diphosphate => Presqualene diphosphate + Pyrophosphate( EC:2.5.1.21 )
subsequently IEV:0003222
event
IMR:0200097
http://purl.org/obo/owl/IMR#IMR_0200097
IMR:0200273
http://purl.org/obo/owl/IMR#IMR_0200273
EC:2.5.1.21
http://purl.org/obo/owl/EC#EC_2.5.1.21
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
KEGG:map00100
http://purl.org/obo/owl/KEGG#KEGG_map00100
KEGG:R00702
http://purl.org/obo/owl/KEGG#KEGG_R00702
Deoxy-uridine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Uracil( EC:2.4.2.4 )
event
EC:2.4.2.4
http://purl.org/obo/owl/EC#EC_2.4.2.4
IMR:0200048
http://purl.org/obo/owl/IMR#IMR_0200048
IMR:0200234
http://purl.org/obo/owl/IMR#IMR_0200234
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200103
http://purl.org/obo/owl/IMR#IMR_0200103
KEGG:R02484
http://purl.org/obo/owl/KEGG#KEGG_R02484
NADPH + Leukotriene B4 + O2 + H+ => NADP+ + 20-OH-Leukotriene B4 + H2O( EC:1.14.13.30 )
NADPH + Leucotriene B4 + O2 => NADP+ + 20-OH-Leukotriene B4 + H2O( EC:1.14.13.30 )
event
KEGG:map00590
http://purl.org/obo/owl/KEGG#KEGG_map00590
KEGG:R03866
http://purl.org/obo/owl/KEGG#KEGG_R03866
IMR:0200376
http://purl.org/obo/owl/IMR#IMR_0200376
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200323
http://purl.org/obo/owl/IMR#IMR_0200323
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
EC:1.14.13.30
http://purl.org/obo/owl/EC#EC_1.14.13.30
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
NAD+ + (R)-Lactic acid = NADH + Pyruvic acid + H+( EC:1.1.1.28 )
NAD+ + (R)-Lactic acid = NADH + Pyruvic acid( EC:1.1.1.28 )
event
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.1.1.28
http://purl.org/obo/owl/EC#EC_1.1.1.28
KEGG:map00620
http://purl.org/obo/owl/KEGG#KEGG_map00620
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200331
http://purl.org/obo/owl/IMR#IMR_0200331
IMR:0200313
http://purl.org/obo/owl/IMR#IMR_0200313
KEGG:R00704
http://purl.org/obo/owl/KEGG#KEGG_R00704
Propanoyl-CoA + Electron-transferring flavoprotein = Propenoyl-CoA + Reduced electron-transferring flavoprotein( EC:1.3.99.3 )
Propanoyl-CoA + Acceptor = Propenoyl-CoA + Reduced acceptor( EC:1.3.99.3 )
event
IMR:0200441
http://purl.org/obo/owl/IMR#IMR_0200441
IMR:0200484
http://purl.org/obo/owl/IMR#IMR_0200484
KEGG:C04253
http://purl.org/obo/owl/KEGG#KEGG_C04253
KEGG:C04570
http://purl.org/obo/owl/KEGG#KEGG_C04570
EC:1.3.99.3
http://purl.org/obo/owl/EC#EC_1.3.99.3
KEGG:map00640
http://purl.org/obo/owl/KEGG#KEGG_map00640
KEGG:R04432
http://purl.org/obo/owl/KEGG#KEGG_R04432
ATP + dGDP = ADP + dGTP( EC:2.7.4.6 )
event
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
EC:2.7.4.6
http://purl.org/obo/owl/EC#EC_2.7.4.6
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R01857
http://purl.org/obo/owl/KEGG#KEGG_R01857
IMR:0200286
http://purl.org/obo/owl/IMR#IMR_0200286
IMR:0200365
http://purl.org/obo/owl/IMR#IMR_0200365
D-Mannose 6-phosphate = beta-D-Fructose 6-phosphate( EC:5.3.1.8 )
D-Mannose 6-phosphate = D-Fructose 6-phosphate( EC:5.3.1.8 )
event
IMR:0200053
http://purl.org/obo/owl/IMR#IMR_0200053
EC:5.3.1.8
http://purl.org/obo/owl/EC#EC_5.3.1.8
KEGG:R01819
http://purl.org/obo/owl/KEGG#KEGG_R01819
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
KEGG:map00051
http://purl.org/obo/owl/KEGG#KEGG_map00051
KEGG:C05345
http://purl.org/obo/owl/KEGG#KEGG_C05345
NADP+ + 10-Formyl-tetrahydro-folic acid + H2O => NADPH + Tetrahydrofolate + CO2 + H+( EC:1.5.1.6 )
NADP+ + 10-Formyl-tetrahydro-folic acid + H2O => NADPH + L-Tetrahydro-folic acid + CO2( EC:1.5.1.6 )
event
KEGG:map00670
http://purl.org/obo/owl/KEGG#KEGG_map00670
KEGG:R00941
http://purl.org/obo/owl/KEGG#KEGG_R00941
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200347
http://purl.org/obo/owl/IMR#IMR_0200347
EC:1.5.1.6
http://purl.org/obo/owl/EC#EC_1.5.1.6
IMR:0200330
http://purl.org/obo/owl/IMR#IMR_0200330
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
NAD+ + N4-Acetylaminobutanal + H2O => NADH + N4-Acetyl-amino-butanoic acid + H+( EC:1.2.1.3 )
NAD+ + N4-Acetyl-amino-butyraldehyde + H2O => NADH + N4-Acetyl-amino-butanoic acid( EC:1.2.1.3 )
event
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
EC:1.2.1.3
http://purl.org/obo/owl/EC#EC_1.2.1.3
IMR:0002041
http://purl.org/obo/owl/IMR#IMR_0002041
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200421
http://purl.org/obo/owl/IMR#IMR_0200421
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:R05050
http://purl.org/obo/owl/KEGG#KEGG_R05050
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
dGMP + H2O => Deoxy-guanosine + Orthophosphate( EC:3.1.3.5 )
event
IMR:0200495
http://purl.org/obo/owl/IMR#IMR_0200495
KEGG:R01968
http://purl.org/obo/owl/KEGG#KEGG_R01968
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
EC:3.1.3.5
http://purl.org/obo/owl/EC#EC_3.1.3.5
IMR:0200505
http://purl.org/obo/owl/IMR#IMR_0200505
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
ATP + 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate => ADP + 1-Phosphatidyl-1D-myo-inositol 3,4,5-triphosphate( EC:2.7.1.153 )
event
EC:2.7.1.153
http://purl.org/obo/owl/EC#EC_2.7.1.153
IMR:0001352
http://purl.org/obo/owl/IMR#IMR_0001352
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001350
http://purl.org/obo/owl/IMR#IMR_0001350
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
KEGG:R04545
http://purl.org/obo/owl/KEGG#KEGG_R04545
KEGG:map04070
http://purl.org/obo/owl/KEGG#KEGG_map04070
S-Adenosyl-L-methionine + L-Adrenaline => S-Adenosyl-L-homocysteine + L-Metanephrine( EC:2.1.1.6 )
event
KEGG:R02920
http://purl.org/obo/owl/KEGG#KEGG_R02920
EC:2.1.1.6
http://purl.org/obo/owl/EC#EC_2.1.1.6
IMR:0100114
http://purl.org/obo/owl/IMR#IMR_0100114
IMR:0200054
http://purl.org/obo/owl/IMR#IMR_0200054
IMR:0200080
http://purl.org/obo/owl/IMR#IMR_0200080
IMR:0200151
http://purl.org/obo/owl/IMR#IMR_0200151
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
ATP + Propanoyl-CoA + HCO3- => ADP + (S)-Methyl-malonyl-CoA + Orthophosphate( EC:6.4.1.3 )
ATP + Propanoyl-CoA + CO2 + H2O => ADP + (S)-Methyl-malonyl-CoA + Orthophosphate( EC:6.4.1.3 )
event
KEGG:R01859
http://purl.org/obo/owl/KEGG#KEGG_R01859
IMR:0200484
http://purl.org/obo/owl/IMR#IMR_0200484
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
KEGG:C00288
http://purl.org/obo/owl/KEGG#KEGG_C00288
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:6.4.1.3
http://purl.org/obo/owl/EC#EC_6.4.1.3
IMR:0200016
http://purl.org/obo/owl/IMR#IMR_0200016
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
KEGG:map00640
http://purl.org/obo/owl/KEGG#KEGG_map00640
2-Oxo-glutaric acid + L-Cysteine-sulfinic acid = L-Glutamic acid + 3-Sulfinyl-pyruvic acid( EC:2.6.1.1 )
event
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0200170
http://purl.org/obo/owl/IMR#IMR_0200170
EC:2.6.1.1
http://purl.org/obo/owl/EC#EC_2.6.1.1
KEGG:map00270
http://purl.org/obo/owl/KEGG#KEGG_map00270
KEGG:R02619
http://purl.org/obo/owl/KEGG#KEGG_R02619
IMR:0200402
http://purl.org/obo/owl/IMR#IMR_0200402
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
ATP + UDP = ADP + UTP( EC:2.7.4.6 )
event
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200199
http://purl.org/obo/owl/IMR#IMR_0200199
EC:2.7.4.6
http://purl.org/obo/owl/EC#EC_2.7.4.6
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
KEGG:R00156
http://purl.org/obo/owl/KEGG#KEGG_R00156
IMR:0200206
http://purl.org/obo/owl/IMR#IMR_0200206
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
Acetyl-CoA + Enzyme N6-(dihydrolipoyl)lysine = CoA + S-acetyldihydrolipoyllysine( EC:2.3.1.12 )
Acetyl-CoA + Dihydro-lipoamide = CoA + 6-S-Acetyl-dihydro-lipoamide( EC:2.3.1.12 )
IEV:0003313
event
Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine( EC:2.3.1.12 )
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
KEGG:C16255
http://purl.org/obo/owl/KEGG#KEGG_C16255
KEGG:C15973
http://purl.org/obo/owl/KEGG#KEGG_C15973
IMR:0200414
http://purl.org/obo/owl/IMR#IMR_0200414
KEGG:R02569
http://purl.org/obo/owl/KEGG#KEGG_R02569
KEGG:map00020
http://purl.org/obo/owl/KEGG#KEGG_map00020
KEGG:map00620
http://purl.org/obo/owl/KEGG#KEGG_map00620
EC:2.3.1.12
http://purl.org/obo/owl/EC#EC_2.3.1.12
L-Kynurenine + H2O => Anthranilic acid + L-Alanine( EC:3.7.1.3 )
event
EC:3.7.1.3
http://purl.org/obo/owl/EC#EC_3.7.1.3
KEGG:R00987
http://purl.org/obo/owl/KEGG#KEGG_R00987
IMR:0200301
http://purl.org/obo/owl/IMR#IMR_0200301
IMR:0200312
http://purl.org/obo/owl/IMR#IMR_0200312
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
IMR:0200251
http://purl.org/obo/owl/IMR#IMR_0200251
ATP + 1-Phosphatidyl-1D-myo-inositol => ADP + 1-Phosphatidyl-1D-myo-inositol 4-phosphate( EC:2.7.1.67 )
event
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
IMR:0200496
http://purl.org/obo/owl/IMR#IMR_0200496
KEGG:R03361
http://purl.org/obo/owl/KEGG#KEGG_R03361
KEGG:map04070
http://purl.org/obo/owl/KEGG#KEGG_map04070
IMR:0200469
http://purl.org/obo/owl/IMR#IMR_0200469
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
EC:2.7.1.67
http://purl.org/obo/owl/EC#EC_2.7.1.67
Phenyl-ethylamine + H2O + O2 => Phenyl-acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
event
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
IMR:0200418
http://purl.org/obo/owl/IMR#IMR_0200418
KEGG:map00360
http://purl.org/obo/owl/KEGG#KEGG_map00360
IMR:0200516
http://purl.org/obo/owl/IMR#IMR_0200516
EC:1.4.3.4
http://purl.org/obo/owl/EC#EC_1.4.3.4
KEGG:R02613
http://purl.org/obo/owl/KEGG#KEGG_R02613
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
Orotidine 5'-phosphate + Pyrophosphate = Orotic acid + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.10 )
5'-Orotidylic acid + Pyrophosphate = Orotic acid + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.10 )
event
EC:2.4.2.10
http://purl.org/obo/owl/EC#EC_2.4.2.10
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
KEGG:R01870
http://purl.org/obo/owl/KEGG#KEGG_R01870
IMR:0200087
http://purl.org/obo/owl/IMR#IMR_0200087
IMR:0200179
http://purl.org/obo/owl/IMR#IMR_0200179
IMR:0200265
http://purl.org/obo/owl/IMR#IMR_0200265
NADP+ + (S)-Malic acid = NADPH + Pyruvic acid + CO2 + H+( EC:1.1.1.40 )
NAD+ + (S)-Malic acid = NADH + Pyruvic acid + CO2( EC:1.1.1.40 )
event
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
KEGG:map00620
http://purl.org/obo/owl/KEGG#KEGG_map00620
KEGG:map00710
http://purl.org/obo/owl/KEGG#KEGG_map00710
KEGG:R00216
http://purl.org/obo/owl/KEGG#KEGG_R00216
EC:1.1.1.40
http://purl.org/obo/owl/EC#EC_1.1.1.40
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200278
http://purl.org/obo/owl/IMR#IMR_0200278
IMR:0200331
http://purl.org/obo/owl/IMR#IMR_0200331
NAD+ + Phenyl-acetaldehyde + H2O = NADH + Phenyl-acetic acid + H+( EC:1.2.1.5 )
NAD+ + Phenyl-acetaldehyde + H2O = NADH + Phenyl-acetic acid( EC:1.2.1.5 )
event
IMR:0200193
http://purl.org/obo/owl/IMR#IMR_0200193
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.2.1.5
http://purl.org/obo/owl/EC#EC_1.2.1.5
KEGG:R02536
http://purl.org/obo/owl/KEGG#KEGG_R02536
KEGG:map00360
http://purl.org/obo/owl/KEGG#KEGG_map00360
KEGG:map00643
http://purl.org/obo/owl/KEGG#KEGG_map00643
IMR:0200418
http://purl.org/obo/owl/IMR#IMR_0200418
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
ATP + 1D-myo-inositol 1,4,5-trisphosphate => ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate( EC:2.7.1.151 )
event
IMR:0100028
http://purl.org/obo/owl/IMR#IMR_0100028
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
EC:2.7.1.151
http://purl.org/obo/owl/EC#EC_2.7.1.151
KEGG:R05800
http://purl.org/obo/owl/KEGG#KEGG_R05800
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
IMR:0200243
http://purl.org/obo/owl/IMR#IMR_0200243
Succinyl-CoA + Acetoacetic acid = Succinic acid + Acetoacetyl-CoA( EC:2.8.3.5 )
event
EC:2.8.3.5
http://purl.org/obo/owl/EC#EC_2.8.3.5
IMR:0200064
http://purl.org/obo/owl/IMR#IMR_0200064
IMR:0200037
http://purl.org/obo/owl/IMR#IMR_0200037
KEGG:R00410
http://purl.org/obo/owl/KEGG#KEGG_R00410
KEGG:map00650
http://purl.org/obo/owl/KEGG#KEGG_map00650
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
KEGG:map00072
http://purl.org/obo/owl/KEGG#KEGG_map00072
IMR:0200119
http://purl.org/obo/owl/IMR#IMR_0200119
IMR:0200410
http://purl.org/obo/owl/IMR#IMR_0200410
Tetrahydrofolate + L-Serine = 5,10-Methylene-tetrahydro-folic acid + Glycine + H2O( EC:2.1.2.1 )
L-Tetrahydro-folic acid + L-Serine = 5,10-Methylene-tetrahydro-folic acid + Glycine + H2O( EC:2.1.2.1 )
event
IMR:0200517
http://purl.org/obo/owl/IMR#IMR_0200517
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
KEGG:map00670
http://purl.org/obo/owl/KEGG#KEGG_map00670
KEGG:R00945
http://purl.org/obo/owl/KEGG#KEGG_R00945
EC:2.1.2.1
http://purl.org/obo/owl/EC#EC_2.1.2.1
IMR:0100118
http://purl.org/obo/owl/IMR#IMR_0100118
IMR:0200453
http://purl.org/obo/owl/IMR#IMR_0200453
IMR:0200330
http://purl.org/obo/owl/IMR#IMR_0200330
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
XTP + H2O => XMP + Pyrophosphate( EC:3.6.1.19 )
event
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200165
http://purl.org/obo/owl/IMR#IMR_0200165
IMR:0200425
http://purl.org/obo/owl/IMR#IMR_0200425
KEGG:R02720
http://purl.org/obo/owl/KEGG#KEGG_R02720
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
EC:3.6.1.19
http://purl.org/obo/owl/EC#EC_3.6.1.19
10-Formyl-tetrahydro-folic acid + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide => Tetrahydrofolate + 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide( EC:2.1.2.3 )
10-Formyl-tetrahydro-folic acid + 5'-Phospho-ribosyl-4-carboxamido-5-amino-imidazole => L-Tetrahydro-folic acid + 5'-Phospho-ribosyl-4-carboxamido-5-formamido-imidazole( EC:2.1.2.3 )
event
KEGG:R04560
http://purl.org/obo/owl/KEGG#KEGG_R04560
KEGG:map00670
http://purl.org/obo/owl/KEGG#KEGG_map00670
IMR:0200452
http://purl.org/obo/owl/IMR#IMR_0200452
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
EC:2.1.2.3
http://purl.org/obo/owl/EC#EC_2.1.2.3
IMR:0200284
http://purl.org/obo/owl/IMR#IMR_0200284
IMR:0200330
http://purl.org/obo/owl/IMR#IMR_0200330
IMR:0200347
http://purl.org/obo/owl/IMR#IMR_0200347
NAD+ + Dihydro-lipoylprotein = NADH + Lipoylprotein + H+( EC:1.8.1.4 )
NAD+ + Dihydro-lipoylprotein = NADH + Lipoylprotein( EC:1.8.1.4 )
event
KEGG:R03815
http://purl.org/obo/owl/KEGG#KEGG_R03815
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
IMR:0200367
http://purl.org/obo/owl/IMR#IMR_0200367
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200336
http://purl.org/obo/owl/IMR#IMR_0200336
EC:1.8.1.4
http://purl.org/obo/owl/EC#EC_1.8.1.4
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
ATP + Pyruvic acid + HCO3- = ADP + Oxaloacetic acid + Orthophosphate( EC:6.4.1.1 )
ATP + Pyruvic acid + CO2 + H2O = ADP + Oxaloacetic acid + Orthophosphate( EC:6.4.1.1 )
event
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200331
http://purl.org/obo/owl/IMR#IMR_0200331
IMR:0200339
http://purl.org/obo/owl/IMR#IMR_0200339
KEGG:C00288
http://purl.org/obo/owl/KEGG#KEGG_C00288
KEGG:map00020
http://purl.org/obo/owl/KEGG#KEGG_map00020
EC:6.4.1.1
http://purl.org/obo/owl/EC#EC_6.4.1.1
KEGG:R00344
http://purl.org/obo/owl/KEGG#KEGG_R00344
KEGG:map00620
http://purl.org/obo/owl/KEGG#KEGG_map00620
Citric acid = cis-Aconitic acid + H2O( EC:4.2.1.3 )
event
IMR:0200271
http://purl.org/obo/owl/IMR#IMR_0200271
EC:4.2.1.3
http://purl.org/obo/owl/EC#EC_4.2.1.3
IMR:0200473
http://purl.org/obo/owl/IMR#IMR_0200473
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00630
http://purl.org/obo/owl/KEGG#KEGG_map00630
KEGG:map00020
http://purl.org/obo/owl/KEGG#KEGG_map00020
KEGG:map00720
http://purl.org/obo/owl/KEGG#KEGG_map00720
KEGG:R01325
http://purl.org/obo/owl/KEGG#KEGG_R01325
D-Glucosamine 6-phosphate + H2O = D-Fructose 6-phosphate + NH3( EC:3.5.99.6 )
event
EC:3.5.99.6
http://purl.org/obo/owl/EC#EC_3.5.99.6
IMR:0200261
http://purl.org/obo/owl/IMR#IMR_0200261
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0200228
http://purl.org/obo/owl/IMR#IMR_0200228
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
KEGG:R00765
http://purl.org/obo/owl/KEGG#KEGG_R00765
Hydroxy-methylbilane => Uroporphyrinogen III + H2O( EC:4.2.1.75 )
event
KEGG:R03165
http://purl.org/obo/owl/KEGG#KEGG_R03165
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00860
http://purl.org/obo/owl/KEGG#KEGG_map00860
IMR:0200002
http://purl.org/obo/owl/IMR#IMR_0200002
IMR:0200315
http://purl.org/obo/owl/IMR#IMR_0200315
EC:4.2.1.75
http://purl.org/obo/owl/EC#EC_4.2.1.75
TPP + 2-Oxo-glutaric acid = 3-Carboxy-1-hydroxypropyl-ThPP + CO2( EC:1.2.4.2 )
subsequently IEV:0003057
event
KEGG:map00020
http://purl.org/obo/owl/KEGG#KEGG_map00020
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
IMR:0200378
http://purl.org/obo/owl/IMR#IMR_0200378
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
KEGG:R00621
http://purl.org/obo/owl/KEGG#KEGG_R00621
IMR:0002042
http://purl.org/obo/owl/IMR#IMR_0002042
EC:1.2.4.2
http://purl.org/obo/owl/EC#EC_1.2.4.2
S-Adenosyl-L-methionine + 3,4-Dihydroxy-phenyl-acetic acid => S-Adenosyl-L-homocysteine + Homovanillic acid( EC:2.1.1.6 )
event
KEGG:R03304
http://purl.org/obo/owl/KEGG#KEGG_R03304
IMR:0200269
http://purl.org/obo/owl/IMR#IMR_0200269
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
EC:2.1.1.6
http://purl.org/obo/owl/EC#EC_2.1.1.6
IMR:0200026
http://purl.org/obo/owl/IMR#IMR_0200026
IMR:0200054
http://purl.org/obo/owl/IMR#IMR_0200054
IMR:0200151
http://purl.org/obo/owl/IMR#IMR_0200151
ATP + D-Glycerate 3-phosphate = ADP + 1,3-Bisphospho-D-glyceric acid( EC:2.7.2.3 )
event
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:2.7.2.3
http://purl.org/obo/owl/EC#EC_2.7.2.3
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
IMR:0200362
http://purl.org/obo/owl/IMR#IMR_0200362
IMR:0200320
http://purl.org/obo/owl/IMR#IMR_0200320
KEGG:map00710
http://purl.org/obo/owl/KEGG#KEGG_map00710
KEGG:R01512
http://purl.org/obo/owl/KEGG#KEGG_R01512
L-Aspartic acid + Carbamoyl phosphate => N-Carbamoyl-L-aspartic acid + Orthophosphate( EC:2.1.3.2 )
event
IMR:0200459
http://purl.org/obo/owl/IMR#IMR_0200459
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
EC:2.1.3.2
http://purl.org/obo/owl/EC#EC_2.1.3.2
IMR:0200077
http://purl.org/obo/owl/IMR#IMR_0200077
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200109
http://purl.org/obo/owl/IMR#IMR_0200109
KEGG:R01397
http://purl.org/obo/owl/KEGG#KEGG_R01397
Prostaglandin H2 = Prostaglandin I2( EC:5.3.99.4 )
event
KEGG:map00590
http://purl.org/obo/owl/KEGG#KEGG_map00590
IMR:0200281
http://purl.org/obo/owl/IMR#IMR_0200281
IMR:0200253
http://purl.org/obo/owl/IMR#IMR_0200253
EC:5.3.99.4
http://purl.org/obo/owl/EC#EC_5.3.99.4
KEGG:R02267
http://purl.org/obo/owl/KEGG#KEGG_R02267
NADP+ + 5,6-Dihydro-uracil = NADPH + Uracil + H+( EC:1.3.1.2 )
NADP+ + 5,6-Dihydro-uracil = NADPH + Uracil( EC:1.3.1.2 )
event
IMR:0200363
http://purl.org/obo/owl/IMR#IMR_0200363
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:R00978
http://purl.org/obo/owl/KEGG#KEGG_R00978
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200234
http://purl.org/obo/owl/IMR#IMR_0200234
EC:1.3.1.2
http://purl.org/obo/owl/EC#EC_1.3.1.2
Nicotinamide D-ribonucleotide + ATP = NAD+ + Pyrophosphate( EC:2.7.7.1 )
event
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:2.7.7.1
http://purl.org/obo/owl/EC#EC_2.7.7.1
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
KEGG:R00137
http://purl.org/obo/owl/KEGG#KEGG_R00137
KEGG:map00760
http://purl.org/obo/owl/KEGG#KEGG_map00760
IMR:0200166
http://purl.org/obo/owl/IMR#IMR_0200166
Pyridoxine + O2 => Pyridoxal + H2O2( EC:1.4.3.5 )
event
KEGG:R01711
http://purl.org/obo/owl/KEGG#KEGG_R01711
KEGG:map00750
http://purl.org/obo/owl/KEGG#KEGG_map00750
IMR:0200504
http://purl.org/obo/owl/IMR#IMR_0200504
IMR:0200344
http://purl.org/obo/owl/IMR#IMR_0200344
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
EC:1.4.3.5
http://purl.org/obo/owl/EC#EC_1.4.3.5
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
NAD+ + 3,4-Dihydroxy-phenyl-ethyleneglycol = NADH + 3,4-Dihydroxy-mandelaldehyde + H+( EC:1.1.1.1 )
NAD+ + 3,4-Dihydroxy-phenyl-ethyleneglycol = NADH + 3,4-Dihydroxy-mandelaldehyde( EC:1.1.1.1 )
event
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200442
http://purl.org/obo/owl/IMR#IMR_0200442
IMR:0200289
http://purl.org/obo/owl/IMR#IMR_0200289
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.1.1.1
http://purl.org/obo/owl/EC#EC_1.1.1.1
KEGG:R04880
http://purl.org/obo/owl/KEGG#KEGG_R04880
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
ATP + IDP = ADP + ITP( EC:2.7.4.6 )
event
EC:2.7.4.6
http://purl.org/obo/owl/EC#EC_2.7.4.6
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200074
http://purl.org/obo/owl/IMR#IMR_0200074
IMR:0200511
http://purl.org/obo/owl/IMR#IMR_0200511
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R00722
http://purl.org/obo/owl/KEGG#KEGG_R00722
NAD+ + 4-Amino-butyraldehyde + H2O => NADH + 4-Amino-butanoic acid + H+( EC:1.2.1.19 )
NAD+ + 4-Amino-butyraldehyde + H2O => NADH + 4-Amino-butanoic acid( EC:1.2.1.19 )
event
IMR:0100117
http://purl.org/obo/owl/IMR#IMR_0100117
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.2.1.19
http://purl.org/obo/owl/EC#EC_1.2.1.19
KEGG:R02549
http://purl.org/obo/owl/KEGG#KEGG_R02549
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200142
http://purl.org/obo/owl/IMR#IMR_0200142
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
KEGG:map00410
http://purl.org/obo/owl/KEGG#KEGG_map00410
5-Formimino-tetrahydro-folic acid + L-Glutamic acid = Tetrahydrofolate + N-Formimino-L-glutamic acid( EC:2.1.2.5 )
5-Formimino-tetrahydro-folic acid + L-Glutamic acid = L-Tetrahydro-folic acid + N-Formimino-L-glutamic acid( EC:2.1.2.5 )
event
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0200211
http://purl.org/obo/owl/IMR#IMR_0200211
IMR:0200330
http://purl.org/obo/owl/IMR#IMR_0200330
IMR:0200443
http://purl.org/obo/owl/IMR#IMR_0200443
KEGG:map00340
http://purl.org/obo/owl/KEGG#KEGG_map00340
KEGG:map00670
http://purl.org/obo/owl/KEGG#KEGG_map00670
KEGG:R02287
http://purl.org/obo/owl/KEGG#KEGG_R02287
EC:2.1.2.5
http://purl.org/obo/owl/EC#EC_2.1.2.5
L-2-Amino-adipic acid + 2-Oxo-glutaric acid = 2-Oxo-adipic acid + L-Glutamic acid( EC:2.6.1.39 )
event
KEGG:map00300
http://purl.org/obo/owl/KEGG#KEGG_map00300
KEGG:map00310
http://purl.org/obo/owl/KEGG#KEGG_map00310
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0200011
http://purl.org/obo/owl/IMR#IMR_0200011
IMR:0200322
http://purl.org/obo/owl/IMR#IMR_0200322
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
KEGG:R01939
http://purl.org/obo/owl/KEGG#KEGG_R01939
EC:2.6.1.39
http://purl.org/obo/owl/EC#EC_2.6.1.39
NAD+ + Succinate semialdehyde + H2O = NADH + Succinic acid + H+( EC:1.2.1.24 )
NAD+ + Succinate semialdehyde + H2O = NADH + Succinic acid( EC:1.2.1.24 )
event
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
EC:1.2.1.24
http://purl.org/obo/owl/EC#EC_1.2.1.24
KEGG:map00650
http://purl.org/obo/owl/KEGG#KEGG_map00650
KEGG:R00713
http://purl.org/obo/owl/KEGG#KEGG_R00713
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200454
http://purl.org/obo/owl/IMR#IMR_0200454
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200119
http://purl.org/obo/owl/IMR#IMR_0200119
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
L-Glutamate 5-semialdehyde => (S)-1-Pyrroline-5-carboxylic acid + H2O( nonenzymatic )
subsequently IEV:0003288
event
KEGG:R03314
http://purl.org/obo/owl/KEGG#KEGG_R03314
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
IMR:0200205
http://purl.org/obo/owl/IMR#IMR_0200205
IMR:0200236
http://purl.org/obo/owl/IMR#IMR_0200236
(S)-Malic acid = Fumaric acid + H2O( EC:4.2.1.2 )
event
IMR:0200186
http://purl.org/obo/owl/IMR#IMR_0200186
IMR:0200278
http://purl.org/obo/owl/IMR#IMR_0200278
EC:4.2.1.2
http://purl.org/obo/owl/EC#EC_4.2.1.2
KEGG:map00720
http://purl.org/obo/owl/KEGG#KEGG_map00720
KEGG:R01082
http://purl.org/obo/owl/KEGG#KEGG_R01082
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00020
http://purl.org/obo/owl/KEGG#KEGG_map00020
NAD+ + (R)-3-Hydroxy-butanoic acid = NADH + Acetoacetic acid + H+( EC:1.1.1.30 )
NAD+ + (R)-3-Hydroxy-butanoic acid = NADH + Acetoacetic acid( EC:1.1.1.30 )
event
IMR:0200218
http://purl.org/obo/owl/IMR#IMR_0200218
IMR:0200064
http://purl.org/obo/owl/IMR#IMR_0200064
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.1.1.30
http://purl.org/obo/owl/EC#EC_1.1.1.30
KEGG:R01361
http://purl.org/obo/owl/KEGG#KEGG_R01361
KEGG:map00072
http://purl.org/obo/owl/KEGG#KEGG_map00072
KEGG:map00650
http://purl.org/obo/owl/KEGG#KEGG_map00650
Adenosine + H2O => Inosine + NH3( EC:3.5.4.4 )
event
KEGG:R01560
http://purl.org/obo/owl/KEGG#KEGG_R01560
IMR:0100126
http://purl.org/obo/owl/IMR#IMR_0100126
EC:3.5.4.4
http://purl.org/obo/owl/EC#EC_3.5.4.4
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0200194
http://purl.org/obo/owl/IMR#IMR_0200194
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
Acetyl-CoA + Glycine = CoA + L-2-Amino-3-oxo-butanoic acid( EC:2.3.1.29 )
event
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
IMR:0100118
http://purl.org/obo/owl/IMR#IMR_0100118
IMR:0200414
http://purl.org/obo/owl/IMR#IMR_0200414
EC:2.3.1.29
http://purl.org/obo/owl/EC#EC_2.3.1.29
KEGG:R00371
http://purl.org/obo/owl/KEGG#KEGG_R00371
KEGG:C03508
http://purl.org/obo/owl/KEGG#KEGG_C03508
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
L-Alanine + 2-Oxo-glutaric acid = Pyruvic acid + L-Glutamic acid( EC:2.6.1.2 )
event
KEGG:map00710
http://purl.org/obo/owl/KEGG#KEGG_map00710
KEGG:R00258
http://purl.org/obo/owl/KEGG#KEGG_R00258
EC:2.6.1.2
http://purl.org/obo/owl/EC#EC_2.6.1.2
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0200251
http://purl.org/obo/owl/IMR#IMR_0200251
IMR:0200331
http://purl.org/obo/owl/IMR#IMR_0200331
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
ADP + Phosphoenol-pyruvic acid => ATP + Pyruvic acid( EC:2.7.1.40 )
event
KEGG:map00710
http://purl.org/obo/owl/KEGG#KEGG_map00710
KEGG:R00200
http://purl.org/obo/owl/KEGG#KEGG_R00200
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:map00620
http://purl.org/obo/owl/KEGG#KEGG_map00620
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:2.7.1.40
http://purl.org/obo/owl/EC#EC_2.7.1.40
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
IMR:0200331
http://purl.org/obo/owl/IMR#IMR_0200331
IMR:0200223
http://purl.org/obo/owl/IMR#IMR_0200223
Prostaglandin H2 => Prostaglandin E2( EC:5.3.99.3 )
event
IMR:0200253
http://purl.org/obo/owl/IMR#IMR_0200253
IMR:0200146
http://purl.org/obo/owl/IMR#IMR_0200146
KEGG:map00590
http://purl.org/obo/owl/KEGG#KEGG_map00590
EC:5.3.99.3
http://purl.org/obo/owl/EC#EC_5.3.99.3
KEGG:R02265
http://purl.org/obo/owl/KEGG#KEGG_R02265
NAD+ + (S)-3-Hydroxy-butanoyl-CoA = NADH + Acetoacetyl-CoA + H+( EC:1.1.1.35 )
NAD+ + (S)-3-Hydroxy-butanoyl-CoA = NADH + Acetoacetyl-CoA( EC:1.1.1.35 )
event
KEGG:map00310
http://purl.org/obo/owl/KEGG#KEGG_map00310
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:map00071
http://purl.org/obo/owl/KEGG#KEGG_map00071
IMR:0200395
http://purl.org/obo/owl/IMR#IMR_0200395
IMR:0200410
http://purl.org/obo/owl/IMR#IMR_0200410
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
EC:1.1.1.35
http://purl.org/obo/owl/EC#EC_1.1.1.35
KEGG:map00650
http://purl.org/obo/owl/KEGG#KEGG_map00650
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
KEGG:R01975
http://purl.org/obo/owl/KEGG#KEGG_R01975
1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + Pyrophosphate = 5-Amino-4-imidazole-carboxyamide + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.7 )
5'-Phospho-ribosyl-4-carboxamido-5-amino-imidazole + Pyrophosphate = 5-Amino-4-imidazole-carboxyamide + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.7 )
event
EC:2.4.2.7
http://purl.org/obo/owl/EC#EC_2.4.2.7
IMR:0200284
http://purl.org/obo/owl/IMR#IMR_0200284
IMR:0200179
http://purl.org/obo/owl/IMR#IMR_0200179
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200291
http://purl.org/obo/owl/IMR#IMR_0200291
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R04378
http://purl.org/obo/owl/KEGG#KEGG_R04378
ATP + D-Fructose => ADP + beta-D-Fructose 6-phosphate( EC:2.7.1.1 )
ATP + D-Fructose => ADP + D-Fructose 6-phosphate( EC:2.7.1.1 )
event
KEGG:R00867
http://purl.org/obo/owl/KEGG#KEGG_R00867
EC:2.7.1.1
http://purl.org/obo/owl/EC#EC_2.7.1.1
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
KEGG:C05345
http://purl.org/obo/owl/KEGG#KEGG_C05345
IMR:0200474
http://purl.org/obo/owl/IMR#IMR_0200474
KEGG:map00051
http://purl.org/obo/owl/KEGG#KEGG_map00051
5,6-Dihydro-uracil + H2O = 3-Ureidopropionate( EC:3.5.2.2 )
5,6-Dihydro-uracil + H2O = Ureido-propanoic acid( EC:3.5.2.2 )
event
EC:3.5.2.2
http://purl.org/obo/owl/EC#EC_3.5.2.2
IMR:0200276
http://purl.org/obo/owl/IMR#IMR_0200276
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200363
http://purl.org/obo/owl/IMR#IMR_0200363
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:map00410
http://purl.org/obo/owl/KEGG#KEGG_map00410
KEGG:map00770
http://purl.org/obo/owl/KEGG#KEGG_map00770
KEGG:R02269
http://purl.org/obo/owl/KEGG#KEGG_R02269
ATP + NAD+ => ADP + NADP+( EC:2.7.1.23 )
event
KEGG:R00104
http://purl.org/obo/owl/KEGG#KEGG_R00104
KEGG:map00760
http://purl.org/obo/owl/KEGG#KEGG_map00760
EC:2.7.1.23
http://purl.org/obo/owl/EC#EC_2.7.1.23
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
Coproporphyrinogen III + O2 => Protoporphyrinogen IX + 2 CO2 + 2 H2O( EC:1.3.3.3 )
Coproporphyrinogen III => Protoporphyrinogen IX + 2 CO2( EC:1.3.3.3 ):multi-step reaction
event
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200258
http://purl.org/obo/owl/IMR#IMR_0200258
EC:1.3.3.3
http://purl.org/obo/owl/EC#EC_1.3.3.3
KEGG:map00860
http://purl.org/obo/owl/KEGG#KEGG_map00860
KEGG:R03220
http://purl.org/obo/owl/KEGG#KEGG_R03220
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200523
http://purl.org/obo/owl/IMR#IMR_0200523
3-Methyl-butanoyl-CoA + FAD = 3-Methylbut-2-enoyl-CoA + FADH2( EC:1.3.99.3 )
3-Methyl-butanoyl-CoA + Acceptor = 3-Methylbut-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.3 )
event
EC:1.3.99.3
http://purl.org/obo/owl/EC#EC_1.3.99.3
IMR:0200158
http://purl.org/obo/owl/IMR#IMR_0200158
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
KEGG:R04095
http://purl.org/obo/owl/KEGG#KEGG_R04095
IMR:0200298
http://purl.org/obo/owl/IMR#IMR_0200298
KEGG:C00016
http://purl.org/obo/owl/KEGG#KEGG_C00016
KEGG:C01352
http://purl.org/obo/owl/KEGG#KEGG_C01352
2-Oxo-glutaric acid + L-erythro-4-Hydroxy-glutamic acid = L-Glutamic acid + D-4-Hydroxy-2-oxo-glutaric acid( EC:2.6.1.1 )
event
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
EC:2.6.1.1
http://purl.org/obo/owl/EC#EC_2.6.1.1
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
IMR:0200091
http://purl.org/obo/owl/IMR#IMR_0200091
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
KEGG:R05052
http://purl.org/obo/owl/KEGG#KEGG_R05052
KEGG:C05946
http://purl.org/obo/owl/KEGG#KEGG_C05946
D-Glycerate 2-phosphate = Phosphoenol-pyruvic acid + H2O( EC:4.2.1.11 )
event
EC:4.2.1.11
http://purl.org/obo/owl/EC#EC_4.2.1.11
IMR:0200223
http://purl.org/obo/owl/IMR#IMR_0200223
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
KEGG:R00658
http://purl.org/obo/owl/KEGG#KEGG_R00658
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200405
http://purl.org/obo/owl/IMR#IMR_0200405
S-Adenosyl-L-homocysteine + H2O => Adenosine + L-Homocysteine( EC:3.3.1.1 )
event
EC:3.3.1.1
http://purl.org/obo/owl/EC#EC_3.3.1.1
KEGG:R00192
http://purl.org/obo/owl/KEGG#KEGG_R00192
KEGG:map00270
http://purl.org/obo/owl/KEGG#KEGG_map00270
IMR:0200039
http://purl.org/obo/owl/IMR#IMR_0200039
IMR:0100126
http://purl.org/obo/owl/IMR#IMR_0100126
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200151
http://purl.org/obo/owl/IMR#IMR_0200151
NADP+ + Cholesterol = NADPH + 7-Dehydro-cholesterol + H+( EC:1.3.1.21 )
NADP+ + Cholesterol = NADPH + 7-Dehydro-cholesterol( EC:1.3.1.21 )
event
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200486
http://purl.org/obo/owl/IMR#IMR_0200486
IMR:0200510
http://purl.org/obo/owl/IMR#IMR_0200510
KEGG:map00100
http://purl.org/obo/owl/KEGG#KEGG_map00100
KEGG:R01456
http://purl.org/obo/owl/KEGG#KEGG_R01456
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
EC:1.3.1.21
http://purl.org/obo/owl/EC#EC_1.3.1.21
NAD+ + Enzyme N6-(dihydrolipoyl)lysine = NADH + Enzyme N6-(lipoyl)lysine + H+( EC:1.8.1.4 )
NAD+ + Dihydro-lipoamide = NADH + Lipoamide( EC:1.8.1.4 )
event
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
EC:1.8.1.4
http://purl.org/obo/owl/EC#EC_1.8.1.4
KEGG:map00620
http://purl.org/obo/owl/KEGG#KEGG_map00620
KEGG:R07618
http://purl.org/obo/owl/KEGG#KEGG_R07618
KEGG:C15972
http://purl.org/obo/owl/KEGG#KEGG_C15972
KEGG:C15973
http://purl.org/obo/owl/KEGG#KEGG_C15973
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
KEGG:map00020
http://purl.org/obo/owl/KEGG#KEGG_map00020
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
Allantoic acid + H2O => (-)-Ureidoglycolate + Urea( EC:3.5.3.4 )
Allantoic acid + H2O => Ureido-glycolic acid + Urea( EC:3.5.3.4 )
event
EC:3.5.3.4
http://purl.org/obo/owl/EC#EC_3.5.3.4
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200437
http://purl.org/obo/owl/IMR#IMR_0200437
IMR:0200093
http://purl.org/obo/owl/IMR#IMR_0200093
IMR:0200111
http://purl.org/obo/owl/IMR#IMR_0200111
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R02422
http://purl.org/obo/owl/KEGG#KEGG_R02422
UDP-D-glucose + alpha-D-Galactose 1-phosphate = D-Glucose 1-phosphate + UDP-D-galactose( EC:2.7.7.12 )
UDP-D-glucose + D-Galactose 1-phosphate = D-Glucose 1-phosphate + UDP-D-galactose( EC:2.7.7.12 )
event
KEGG:R00955
http://purl.org/obo/owl/KEGG#KEGG_R00955
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
EC:2.7.7.12
http://purl.org/obo/owl/EC#EC_2.7.7.12
IMR:0200190
http://purl.org/obo/owl/IMR#IMR_0200190
IMR:0200304
http://purl.org/obo/owl/IMR#IMR_0200304
KEGG:map00052
http://purl.org/obo/owl/KEGG#KEGG_map00052
IMR:0200227
http://purl.org/obo/owl/IMR#IMR_0200227
IMR:0200283
http://purl.org/obo/owl/IMR#IMR_0200283
1D-myo-Inositol 4-phosphate + H2O => myo-Inositol + Orthophosphate( EC:3.1.3.25 )
event
EC:3.1.3.25
http://purl.org/obo/owl/EC#EC_3.1.3.25
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
KEGG:R01186
http://purl.org/obo/owl/KEGG#KEGG_R01186
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
KEGG:map04070
http://purl.org/obo/owl/KEGG#KEGG_map04070
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200419
http://purl.org/obo/owl/IMR#IMR_0200419
IMR:0200177
http://purl.org/obo/owl/IMR#IMR_0200177
2-Oxo-glutaric acid + L-Cysteine = DL-Glutamic acid + 3-Mercapto-pyruvic acid( EC:2.6.1.1 )
2-Oxo-glutaric acid + L-Cysteine = L-Glutamic acid + 3-Mercapto-pyruvic acid( EC:2.6.1.1 )
event
KEGG:R00896
http://purl.org/obo/owl/KEGG#KEGG_R00896
KEGG:C00302
http://purl.org/obo/owl/KEGG#KEGG_C00302
KEGG:map00270
http://purl.org/obo/owl/KEGG#KEGG_map00270
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
IMR:0200467
http://purl.org/obo/owl/IMR#IMR_0200467
IMR:0200007
http://purl.org/obo/owl/IMR#IMR_0200007
EC:2.6.1.1
http://purl.org/obo/owl/EC#EC_2.6.1.1
NAD+ + (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA = NADH + 2-Methyl-3-acetoacetyl-CoA + H+( EC:1.1.1.35 )
NAD+ + (S)-3-Hydroxy-2-methyl-butanoyl-CoA = NADH + 2-Methyl-3-acetoacetyl-CoA( EC:1.1.1.35 )
event
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200288
http://purl.org/obo/owl/IMR#IMR_0200288
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200207
http://purl.org/obo/owl/IMR#IMR_0200207
EC:1.1.1.35
http://purl.org/obo/owl/EC#EC_1.1.1.35
KEGG:R04203
http://purl.org/obo/owl/KEGG#KEGG_R04203
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
Glutaryl-CoA + Acceptor => Crotonoyl-CoA + CO2 + Reduced acceptor( EC:1.3.99.7 )
event
KEGG:map00310
http://purl.org/obo/owl/KEGG#KEGG_map00310
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
KEGG:R02488
http://purl.org/obo/owl/KEGG#KEGG_R02488
EC:1.3.99.7
http://purl.org/obo/owl/EC#EC_1.3.99.7
IMR:0200224
http://purl.org/obo/owl/IMR#IMR_0200224
IMR:0200121
http://purl.org/obo/owl/IMR#IMR_0200121
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200300
http://purl.org/obo/owl/IMR#IMR_0200300
IMR:0200256
http://purl.org/obo/owl/IMR#IMR_0200256
ATP + dTMP = ADP + dTDP( EC:2.7.4.9 )
event
IMR:0200338
http://purl.org/obo/owl/IMR#IMR_0200338
EC:2.7.4.9
http://purl.org/obo/owl/EC#EC_2.7.4.9
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200187
http://purl.org/obo/owl/IMR#IMR_0200187
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:R02094
http://purl.org/obo/owl/KEGG#KEGG_R02094
D-Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate = D-Ribose 5-phosphate + D-Xylulose 5-phosphate( EC:2.2.1.1 )
event
IMR:0200169
http://purl.org/obo/owl/IMR#IMR_0200169
KEGG:map00030
http://purl.org/obo/owl/KEGG#KEGG_map00030
IMR:0200060
http://purl.org/obo/owl/IMR#IMR_0200060
IMR:0200141
http://purl.org/obo/owl/IMR#IMR_0200141
EC:2.2.1.1
http://purl.org/obo/owl/EC#EC_2.2.1.1
IMR:0200058
http://purl.org/obo/owl/IMR#IMR_0200058
KEGG:R01641
http://purl.org/obo/owl/KEGG#KEGG_R01641
KEGG:map00710
http://purl.org/obo/owl/KEGG#KEGG_map00710
2-Oxo-glutaric acid + L-Cysteic acid = L-Glutamic acid + 3-Sulfo-pyruvic acid( EC:2.6.1.1 )
event
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0200397
http://purl.org/obo/owl/IMR#IMR_0200397
EC:2.6.1.1
http://purl.org/obo/owl/EC#EC_2.6.1.1
KEGG:map00270
http://purl.org/obo/owl/KEGG#KEGG_map00270
KEGG:R02433
http://purl.org/obo/owl/KEGG#KEGG_R02433
IMR:0200417
http://purl.org/obo/owl/IMR#IMR_0200417
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
NAD+ + Methylimidazole acetaldehyde + H2O = NADH + Methylimidazoleacetic acid + H+( EC:1.2.1.5 )
NAD+ + 3-Methyl-imidazole acetaldehyde + H2O = NADH + 3-Methyl-imidazole-acetic acid( EC:1.2.1.5 )
event
EC:1.2.1.5
http://purl.org/obo/owl/EC#EC_1.2.1.5
KEGG:map00340
http://purl.org/obo/owl/KEGG#KEGG_map00340
KEGG:R04996
http://purl.org/obo/owl/KEGG#KEGG_R04996
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200325
http://purl.org/obo/owl/IMR#IMR_0200325
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200114
http://purl.org/obo/owl/IMR#IMR_0200114
5,6-Dihydro-thymine + H2O = 3-Ureidoisobutyrate( EC:3.5.2.2 )
5,6-Dihydro-thymine + H2O = 3-Ureido-2-methyl-propanoic acid( EC:3.5.2.2 )
event
EC:3.5.2.2
http://purl.org/obo/owl/EC#EC_3.5.2.2
IMR:0200132
http://purl.org/obo/owl/IMR#IMR_0200132
IMR:0200343
http://purl.org/obo/owl/IMR#IMR_0200343
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:R03055
http://purl.org/obo/owl/KEGG#KEGG_R03055
NAD+ + (S)-3-Hydroxyisobutyrate = NADH + (S)-Methyl-malonate semialdehyde + H+( EC:1.1.1.35 )
NAD+ + (S)-3-Hydroxy-2-methyl-propanoic acid = NADH + (S)-Methyl-malonate semialdehyde( EC:1.1.1.35 )
event
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
EC:1.1.1.35
http://purl.org/obo/owl/EC#EC_1.1.1.35
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
KEGG:R05066
http://purl.org/obo/owl/KEGG#KEGG_R05066
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200385
http://purl.org/obo/owl/IMR#IMR_0200385
IMR:0200297
http://purl.org/obo/owl/IMR#IMR_0200297
NADP+ + beta-D-Glucose = NADPH + D-Glucono-1,5-lactone + H+( EC:1.1.1.47 )
NADP+ + D-Glucose = NADPH + D-Glucono-1,5-lactone( EC:1.1.1.47 )
event
KEGG:C00221
http://purl.org/obo/owl/KEGG#KEGG_C00221
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
KEGG:R01521
http://purl.org/obo/owl/KEGG#KEGG_R01521
KEGG:map00030
http://purl.org/obo/owl/KEGG#KEGG_map00030
IMR:0200242
http://purl.org/obo/owl/IMR#IMR_0200242
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.1.1.47
http://purl.org/obo/owl/EC#EC_1.1.1.47
NADP+ + 5,6-Dihydro-thymine = NADPH + Thymine + H+( EC:1.3.1.2 )
NADP+ + 5,6-Dihydro-thymine = NADPH + Thymine( EC:1.3.1.2 )
event
EC:1.3.1.2
http://purl.org/obo/owl/EC#EC_1.3.1.2
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200343
http://purl.org/obo/owl/IMR#IMR_0200343
IMR:0200036
http://purl.org/obo/owl/IMR#IMR_0200036
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
KEGG:R01415
http://purl.org/obo/owl/KEGG#KEGG_R01415
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
D-Glycerate 2-phosphate = D-Glycerate 3-phosphate( EC:5.4.2.1 )
event
KEGG:R01518
http://purl.org/obo/owl/KEGG#KEGG_R01518
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
IMR:0200405
http://purl.org/obo/owl/IMR#IMR_0200405
IMR:0200320
http://purl.org/obo/owl/IMR#IMR_0200320
EC:5.4.2.1
http://purl.org/obo/owl/EC#EC_5.4.2.1
GTP + Oxaloacetic acid = GDP + Phosphoenol-pyruvic acid + CO2( EC:4.1.1.32 )
event
KEGG:R00431
http://purl.org/obo/owl/KEGG#KEGG_R00431
KEGG:map00620
http://purl.org/obo/owl/KEGG#KEGG_map00620
KEGG:map00020
http://purl.org/obo/owl/KEGG#KEGG_map00020
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
IMR:0200339
http://purl.org/obo/owl/IMR#IMR_0200339
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200223
http://purl.org/obo/owl/IMR#IMR_0200223
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
EC:4.1.1.32
http://purl.org/obo/owl/EC#EC_4.1.1.32
D-Ribose 5-phosphate = D-Ribulose 5-phosphate( EC:5.3.1.6 )
event
KEGG:R01056
http://purl.org/obo/owl/KEGG#KEGG_R01056
KEGG:map00030
http://purl.org/obo/owl/KEGG#KEGG_map00030
KEGG:map00710
http://purl.org/obo/owl/KEGG#KEGG_map00710
IMR:0200060
http://purl.org/obo/owl/IMR#IMR_0200060
IMR:0200061
http://purl.org/obo/owl/IMR#IMR_0200061
EC:5.3.1.6
http://purl.org/obo/owl/EC#EC_5.3.1.6
(R)-Methyl-malonyl-CoA = (S)-Methyl-malonyl-CoA( EC:5.1.99.1 )
event
KEGG:R02765
http://purl.org/obo/owl/KEGG#KEGG_R02765
KEGG:map00640
http://purl.org/obo/owl/KEGG#KEGG_map00640
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
IMR:0200515
http://purl.org/obo/owl/IMR#IMR_0200515
EC:5.1.99.1
http://purl.org/obo/owl/EC#EC_5.1.99.1
IMR:0200016
http://purl.org/obo/owl/IMR#IMR_0200016
Prostaglandin H2 => Thromboxane A2( EC:5.3.99.5 )
event
KEGG:R02268
http://purl.org/obo/owl/KEGG#KEGG_R02268
IMR:0200489
http://purl.org/obo/owl/IMR#IMR_0200489
KEGG:map00590
http://purl.org/obo/owl/KEGG#KEGG_map00590
IMR:0200253
http://purl.org/obo/owl/IMR#IMR_0200253
EC:5.3.99.5
http://purl.org/obo/owl/EC#EC_5.3.99.5
NAD+ + 4-Trimethyl-ammonio-butanal + H2O = NADH + 4-Trimethyl-ammonio-butanoic acid + H+( EC:1.2.1.3 )
NAD+ + 4-Trimethyl-ammonio-butanal + H2O = NADH + 4-Trimethyl-ammonio-butanoic acid( EC:1.2.1.3 )
event
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200070
http://purl.org/obo/owl/IMR#IMR_0200070
IMR:0200168
http://purl.org/obo/owl/IMR#IMR_0200168
EC:1.2.1.3
http://purl.org/obo/owl/EC#EC_1.2.1.3
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
KEGG:R03283
http://purl.org/obo/owl/KEGG#KEGG_R03283
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:map00310
http://purl.org/obo/owl/KEGG#KEGG_map00310
4-Maleyl-acetoacetic acid => 4-Fumaryl-acetoacetic acid( EC:5.2.1.2 )
event
KEGG:map00643
http://purl.org/obo/owl/KEGG#KEGG_map00643
KEGG:R03181
http://purl.org/obo/owl/KEGG#KEGG_R03181
IMR:0200507
http://purl.org/obo/owl/IMR#IMR_0200507
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
EC:5.2.1.2
http://purl.org/obo/owl/EC#EC_5.2.1.2
IMR:0200245
http://purl.org/obo/owl/IMR#IMR_0200245
N-Ribosyl-nicotinamide + Orthophosphate = Nicotinamide + D-Ribose 1-phosphate( EC:2.4.2.1 )
event
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200479
http://purl.org/obo/owl/IMR#IMR_0200479
KEGG:R02294
http://purl.org/obo/owl/KEGG#KEGG_R02294
KEGG:map00760
http://purl.org/obo/owl/KEGG#KEGG_map00760
KEGG:C00620
http://purl.org/obo/owl/KEGG#KEGG_C00620
EC:2.4.2.1
http://purl.org/obo/owl/EC#EC_2.4.2.1
IMR:0200025
http://purl.org/obo/owl/IMR#IMR_0200025
ATP + L-Glutamic acid + NH3 = ADP + L-Glutamine + Orthophosphate( EC:6.3.1.2 )
event
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0200448
http://purl.org/obo/owl/IMR#IMR_0200448
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
KEGG:map00910
http://purl.org/obo/owl/KEGG#KEGG_map00910
EC:6.3.1.2
http://purl.org/obo/owl/EC#EC_6.3.1.2
KEGG:R00253
http://purl.org/obo/owl/KEGG#KEGG_R00253
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
5-Methyl-tetrahydro-folic acid + L-Homocysteine => Tetrahydrofolate + L-Methionine( EC:2.1.1.13 )
5-Methyl-tetrahydro-folic acid + L-Homocysteine => L-Tetrahydro-folic acid + L-Methionine( EC:2.1.1.13 )
event
IMR:0200330
http://purl.org/obo/owl/IMR#IMR_0200330
IMR:0200408
http://purl.org/obo/owl/IMR#IMR_0200408
KEGG:map00270
http://purl.org/obo/owl/KEGG#KEGG_map00270
EC:2.1.1.13
http://purl.org/obo/owl/EC#EC_2.1.1.13
IMR:0200488
http://purl.org/obo/owl/IMR#IMR_0200488
KEGG:R00946
http://purl.org/obo/owl/KEGG#KEGG_R00946
KEGG:map00670
http://purl.org/obo/owl/KEGG#KEGG_map00670
IMR:0200039
http://purl.org/obo/owl/IMR#IMR_0200039
ATP + L-Methionine + tRNA(Met) => AMP + L-Methionyl-tRNA(Met) + Pyrophosphate( EC:6.1.1.10 )
event
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0200034
http://purl.org/obo/owl/IMR#IMR_0200034
KEGG:R03659
http://purl.org/obo/owl/KEGG#KEGG_R03659
KEGG:map00970
http://purl.org/obo/owl/KEGG#KEGG_map00970
IMR:0200488
http://purl.org/obo/owl/IMR#IMR_0200488
IMR:0200355
http://purl.org/obo/owl/IMR#IMR_0200355
EC:6.1.1.10
http://purl.org/obo/owl/EC#EC_6.1.1.10
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
AMP + Pyrophosphate = Adenine + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.7 )
AMP + Pyrophosphate = Adenine + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.7 )
event
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
KEGG:R00190
http://purl.org/obo/owl/KEGG#KEGG_R00190
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
EC:2.4.2.7
http://purl.org/obo/owl/EC#EC_2.4.2.7
IMR:0200350
http://purl.org/obo/owl/IMR#IMR_0200350
IMR:0200179
http://purl.org/obo/owl/IMR#IMR_0200179
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
L-Serine => Pyruvic acid + NH3( EC:4.3.1.17 )
event
EC:4.3.1.17
http://purl.org/obo/owl/EC#EC_4.3.1.17
IMR:0200331
http://purl.org/obo/owl/IMR#IMR_0200331
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0200453
http://purl.org/obo/owl/IMR#IMR_0200453
KEGG:R00220
http://purl.org/obo/owl/KEGG#KEGG_R00220
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
NADPH + 6,7-Dihydro-biopterin + H+ => NADP+ + Tetrahydrobiopterin( EC:1.5.1.34 )
NADPH + 6,7-Dihydro-biopterin => NADP+ + 5,6,7,8-Tetrahydro-biopterin( EC:1.5.1.34 )
event
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200209
http://purl.org/obo/owl/IMR#IMR_0200209
KEGG:R01794
http://purl.org/obo/owl/KEGG#KEGG_R01794
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200045
http://purl.org/obo/owl/IMR#IMR_0200045
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.5.1.34
http://purl.org/obo/owl/EC#EC_1.5.1.34
KEGG:map00790
http://purl.org/obo/owl/KEGG#KEGG_map00790
ATP + dGMP = ADP + dGDP( EC:2.7.4.8 )
event
IMR:0200365
http://purl.org/obo/owl/IMR#IMR_0200365
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:2.7.4.8
http://purl.org/obo/owl/EC#EC_2.7.4.8
KEGG:R02090
http://purl.org/obo/owl/KEGG#KEGG_R02090
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200505
http://purl.org/obo/owl/IMR#IMR_0200505
Melatonin + O2 + Reduced flavoprotein => 6-Hydroxy-melatonin + H2O + Oxidized flavoprotein( EC:1.14.14.1 )
event
IMR:0200519
http://purl.org/obo/owl/IMR#IMR_0200519
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
KEGG:R03629
http://purl.org/obo/owl/KEGG#KEGG_R03629
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200041
http://purl.org/obo/owl/IMR#IMR_0200041
IMR:0200450
http://purl.org/obo/owl/IMR#IMR_0200450
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0100069
http://purl.org/obo/owl/IMR#IMR_0100069
EC:1.14.14.1
http://purl.org/obo/owl/EC#EC_1.14.14.1
IMP + Pyrophosphate = Hypoxanthine + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.8 )
IMP + Pyrophosphate = Hypoxanthine + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.8 )
event
IMR:0200173
http://purl.org/obo/owl/IMR#IMR_0200173
EC:2.4.2.8
http://purl.org/obo/owl/EC#EC_2.4.2.8
IMR:0200221
http://purl.org/obo/owl/IMR#IMR_0200221
IMR:0200179
http://purl.org/obo/owl/IMR#IMR_0200179
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
KEGG:R01132
http://purl.org/obo/owl/KEGG#KEGG_R01132
2,5-Dihydroxy-phenyl-acetic acid + O2 => 4-Maleyl-acetoacetic acid( EC:1.13.11.5 )
event
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
EC:1.13.11.5
http://purl.org/obo/owl/EC#EC_1.13.11.5
IMR:0200245
http://purl.org/obo/owl/IMR#IMR_0200245
KEGG:map00643
http://purl.org/obo/owl/KEGG#KEGG_map00643
KEGG:R02519
http://purl.org/obo/owl/KEGG#KEGG_R02519
IMR:0200254
http://purl.org/obo/owl/IMR#IMR_0200254
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
NADPH + Folic acid + H+ => NADP+ + 7,8-Dihydro-folic acid( EC:1.5.1.3 )
NADPH + Folic acid => NADP+ + 7,8-Dihydro-folic acid( EC:1.5.1.3 )
event
IMR:0200356
http://purl.org/obo/owl/IMR#IMR_0200356
KEGG:R02236
http://purl.org/obo/owl/KEGG#KEGG_R02236
KEGG:map00790
http://purl.org/obo/owl/KEGG#KEGG_map00790
KEGG:map00670
http://purl.org/obo/owl/KEGG#KEGG_map00670
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.5.1.3
http://purl.org/obo/owl/EC#EC_1.5.1.3
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200185
http://purl.org/obo/owl/IMR#IMR_0200185
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
3-Hydroxy-propanoyl-CoA = Propenoyl-CoA + H2O( EC:4.2.1.17 )
event
KEGG:map00410
http://purl.org/obo/owl/KEGG#KEGG_map00410
KEGG:map00640
http://purl.org/obo/owl/KEGG#KEGG_map00640
KEGG:R03045
http://purl.org/obo/owl/KEGG#KEGG_R03045
EC:4.2.1.17
http://purl.org/obo/owl/EC#EC_4.2.1.17
IMR:0200200
http://purl.org/obo/owl/IMR#IMR_0200200
IMR:0200441
http://purl.org/obo/owl/IMR#IMR_0200441
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
Farnesyl diphosphate + Isopentenyl diphosphate = Geranyl-geranyl diphosphate + Pyrophosphate( EC:2.5.1.29 )
event
KEGG:R02061
http://purl.org/obo/owl/KEGG#KEGG_R02061
KEGG:map00900
http://purl.org/obo/owl/KEGG#KEGG_map00900
IMR:0200316
http://purl.org/obo/owl/IMR#IMR_0200316
IMR:0200097
http://purl.org/obo/owl/IMR#IMR_0200097
EC:2.5.1.29
http://purl.org/obo/owl/EC#EC_2.5.1.29
IMR:0200287
http://purl.org/obo/owl/IMR#IMR_0200287
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
NAD+ + (S)-Lactic acid = NADH + Pyruvic acid + H+( EC:1.1.1.27 )
NAD+ + (S)-Lactic acid = NADH + Pyruvic acid( EC:1.1.1.27 )
event
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
KEGG:map00620
http://purl.org/obo/owl/KEGG#KEGG_map00620
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.1.1.27
http://purl.org/obo/owl/EC#EC_1.1.1.27
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200331
http://purl.org/obo/owl/IMR#IMR_0200331
IMR:0200270
http://purl.org/obo/owl/IMR#IMR_0200270
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
KEGG:R00703
http://purl.org/obo/owl/KEGG#KEGG_R00703
Dimethylallyl diphosphate = Isopentenyl diphosphate( EC:5.3.3.2 )
event
IMR:0200094
http://purl.org/obo/owl/IMR#IMR_0200094
EC:5.3.3.2
http://purl.org/obo/owl/EC#EC_5.3.3.2
KEGG:map00900
http://purl.org/obo/owl/KEGG#KEGG_map00900
IMR:0200287
http://purl.org/obo/owl/IMR#IMR_0200287
KEGG:R01123
http://purl.org/obo/owl/KEGG#KEGG_R01123
Guanine + H2O => Xanthine + NH3( EC:3.5.4.3 )
event
EC:3.5.4.3
http://purl.org/obo/owl/EC#EC_3.5.4.3
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
KEGG:R01676
http://purl.org/obo/owl/KEGG#KEGG_R01676
IMR:0200319
http://purl.org/obo/owl/IMR#IMR_0200319
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200439
http://purl.org/obo/owl/IMR#IMR_0200439
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
ITP + H2O => IDP + Orthophosphate( EC:3.6.1.5 )
event
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200074
http://purl.org/obo/owl/IMR#IMR_0200074
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:R00719
http://purl.org/obo/owl/KEGG#KEGG_R00719
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200511
http://purl.org/obo/owl/IMR#IMR_0200511
EC:3.6.1.5
http://purl.org/obo/owl/EC#EC_3.6.1.5
L-Glutamine + D-Fructose 6-phosphate = L-Glutamic acid + D-Glucosamine 6-phosphate( EC:2.6.1.16 )
event
EC:2.6.1.16
http://purl.org/obo/owl/EC#EC_2.6.1.16
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0200228
http://purl.org/obo/owl/IMR#IMR_0200228
IMR:0200448
http://purl.org/obo/owl/IMR#IMR_0200448
IMR:0200261
http://purl.org/obo/owl/IMR#IMR_0200261
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
KEGG:R00768
http://purl.org/obo/owl/KEGG#KEGG_R00768
ATP + UMP = ADP + UDP( EC:2.7.4.14 )
event
KEGG:R00158
http://purl.org/obo/owl/KEGG#KEGG_R00158
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0200409
http://purl.org/obo/owl/IMR#IMR_0200409
IMR:0200206
http://purl.org/obo/owl/IMR#IMR_0200206
EC:2.7.4.14
http://purl.org/obo/owl/EC#EC_2.7.4.14
XMP + Pyrophosphate = Xanthine + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.8 )
XMP + Pyrophosphate = Xanthine + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.8 )
event
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200179
http://purl.org/obo/owl/IMR#IMR_0200179
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200439
http://purl.org/obo/owl/IMR#IMR_0200439
IMR:0200165
http://purl.org/obo/owl/IMR#IMR_0200165
EC:2.4.2.8
http://purl.org/obo/owl/EC#EC_2.4.2.8
KEGG:R02142
http://purl.org/obo/owl/KEGG#KEGG_R02142
D-Fructose 2,6-bisphosphate + H2O => beta-D-Fructose 6-phosphate + Orthophosphate( EC:3.1.3.46 )
D-Fructose 2,6-bisphosphate + H2O => D-Fructose 6-phosphate + Orthophosphate( EC:3.1.3.46 )
event
EC:3.1.3.46
http://purl.org/obo/owl/EC#EC_3.1.3.46
KEGG:R02731
http://purl.org/obo/owl/KEGG#KEGG_R02731
KEGG:map00051
http://purl.org/obo/owl/KEGG#KEGG_map00051
KEGG:C05345
http://purl.org/obo/owl/KEGG#KEGG_C05345
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200263
http://purl.org/obo/owl/IMR#IMR_0200263
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
(S)-Dihydro-orotic acid + O2 = Orotic acid + H2O2( EC:1.3.3.1 )
event
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0200393
http://purl.org/obo/owl/IMR#IMR_0200393
KEGG:R01867
http://purl.org/obo/owl/KEGG#KEGG_R01867
IMR:0200265
http://purl.org/obo/owl/IMR#IMR_0200265
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
EC:1.3.3.1
http://purl.org/obo/owl/EC#EC_1.3.3.1
ATP + 2-Deoxy-D-ribose => ADP + 2-Deoxy-D-ribose 5-phosphate( EC:2.7.1.15 )
event
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0200449
http://purl.org/obo/owl/IMR#IMR_0200449
IMR:0200147
http://purl.org/obo/owl/IMR#IMR_0200147
KEGG:map00030
http://purl.org/obo/owl/KEGG#KEGG_map00030
KEGG:R02750
http://purl.org/obo/owl/KEGG#KEGG_R02750
EC:2.7.1.15
http://purl.org/obo/owl/EC#EC_2.7.1.15
2-Methyl-propanoyl-CoA + Acceptor = 2-Methylprop-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.3 )
event
EC:1.3.99.3
http://purl.org/obo/owl/EC#EC_1.3.99.3
IMR:0200174
http://purl.org/obo/owl/IMR#IMR_0200174
IMR:0200164
http://purl.org/obo/owl/IMR#IMR_0200164
IMR:0200300
http://purl.org/obo/owl/IMR#IMR_0200300
IMR:0200224
http://purl.org/obo/owl/IMR#IMR_0200224
KEGG:R02661
http://purl.org/obo/owl/KEGG#KEGG_R02661
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
dUMP + 5,10-Methylene-tetrahydro-folic acid => dTMP + 7,8-Dihydro-folic acid( EC:2.1.1.45 )
event
IMR:0200185
http://purl.org/obo/owl/IMR#IMR_0200185
IMR:0200008
http://purl.org/obo/owl/IMR#IMR_0200008
IMR:0200517
http://purl.org/obo/owl/IMR#IMR_0200517
IMR:0200187
http://purl.org/obo/owl/IMR#IMR_0200187
EC:2.1.1.45
http://purl.org/obo/owl/EC#EC_2.1.1.45
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:map00670
http://purl.org/obo/owl/KEGG#KEGG_map00670
KEGG:R02101
http://purl.org/obo/owl/KEGG#KEGG_R02101
Nicotinamide D-ribonucleotide + H2O => N-Ribosyl-nicotinamide + Orthophosphate( EC:3.1.3.5 )
event
KEGG:R02323
http://purl.org/obo/owl/KEGG#KEGG_R02323
KEGG:map00760
http://purl.org/obo/owl/KEGG#KEGG_map00760
EC:3.1.3.5
http://purl.org/obo/owl/EC#EC_3.1.3.5
IMR:0200479
http://purl.org/obo/owl/IMR#IMR_0200479
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200166
http://purl.org/obo/owl/IMR#IMR_0200166
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
L-Tryptophan + Tetrahydrobiopterin + O2 => 5-Hydroxy-L-tryptophan + 6,7-Dihydro-biopterin + H2O( EC:1.14.16.4 )
event
IMR:0200112
http://purl.org/obo/owl/IMR#IMR_0200112
IMR:0200045
http://purl.org/obo/owl/IMR#IMR_0200045
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200209
http://purl.org/obo/owl/IMR#IMR_0200209
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200307
http://purl.org/obo/owl/IMR#IMR_0200307
EC:1.14.16.4
http://purl.org/obo/owl/EC#EC_1.14.16.4
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
KEGG:R01814
http://purl.org/obo/owl/KEGG#KEGG_R01814
GMP + Pyrophosphate = Guanine + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.7 )
GMP + Pyrophosphate = Guanine + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.7 )
event
IMR:0200179
http://purl.org/obo/owl/IMR#IMR_0200179
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R01229
http://purl.org/obo/owl/KEGG#KEGG_R01229
IMR:0200292
http://purl.org/obo/owl/IMR#IMR_0200292
IMR:0200319
http://purl.org/obo/owl/IMR#IMR_0200319
EC:2.4.2.7
http://purl.org/obo/owl/EC#EC_2.4.2.7
ATP + dAMP = ADP + dADP( EC:2.7.4.3 )
event
IMR:0200160
http://purl.org/obo/owl/IMR#IMR_0200160
IMR:0200237
http://purl.org/obo/owl/IMR#IMR_0200237
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R01547
http://purl.org/obo/owl/KEGG#KEGG_R01547
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:2.7.4.3
http://purl.org/obo/owl/EC#EC_2.7.4.3
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
5,10-Methenyl-tetrahydro-folic acid + H2O = 10-Formyl-tetrahydro-folic acid + H+( EC:3.5.4.9 )
5,10-Methenyl-tetrahydro-folic acid + H2O = 10-Formyl-tetrahydro-folic acid( EC:3.5.4.9 )
event
KEGG:map00630
http://purl.org/obo/owl/KEGG#KEGG_map00630
KEGG:map00670
http://purl.org/obo/owl/KEGG#KEGG_map00670
KEGG:R01655
http://purl.org/obo/owl/KEGG#KEGG_R01655
EC:3.5.4.9
http://purl.org/obo/owl/EC#EC_3.5.4.9
IMR:0200159
http://purl.org/obo/owl/IMR#IMR_0200159
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200347
http://purl.org/obo/owl/IMR#IMR_0200347
(S)-3-Hydroxy-butanoyl-CoA = Crotonoyl-CoA + H2O( EC:4.2.1.17 )
event
IMR:0200121
http://purl.org/obo/owl/IMR#IMR_0200121
EC:4.2.1.17
http://purl.org/obo/owl/EC#EC_4.2.1.17
IMR:0200395
http://purl.org/obo/owl/IMR#IMR_0200395
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00310
http://purl.org/obo/owl/KEGG#KEGG_map00310
KEGG:map00071
http://purl.org/obo/owl/KEGG#KEGG_map00071
KEGG:R03026
http://purl.org/obo/owl/KEGG#KEGG_R03026
KEGG:map00632
http://purl.org/obo/owl/KEGG#KEGG_map00632
KEGG:map00650
http://purl.org/obo/owl/KEGG#KEGG_map00650
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
Acetyl-CoA + Oxaloacetic acid + H2O => CoA + Citric acid( EC:2.3.3.1 )
event
EC:2.3.3.1
http://purl.org/obo/owl/EC#EC_2.3.3.1
KEGG:R00351
http://purl.org/obo/owl/KEGG#KEGG_R00351
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
IMR:0200339
http://purl.org/obo/owl/IMR#IMR_0200339
IMR:0200473
http://purl.org/obo/owl/IMR#IMR_0200473
IMR:0200414
http://purl.org/obo/owl/IMR#IMR_0200414
KEGG:map00630
http://purl.org/obo/owl/KEGG#KEGG_map00630
KEGG:map00020
http://purl.org/obo/owl/KEGG#KEGG_map00020
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
L-Cystathionine + H2O => L-Cysteine + 2-Oxo-butanoic acid + NH3( EC:4.4.1.1 )
event
KEGG:R01001
http://purl.org/obo/owl/KEGG#KEGG_R01001
KEGG:map00910
http://purl.org/obo/owl/KEGG#KEGG_map00910
IMR:0200127
http://purl.org/obo/owl/IMR#IMR_0200127
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
EC:4.4.1.1
http://purl.org/obo/owl/EC#EC_4.4.1.1
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
KEGG:map00270
http://purl.org/obo/owl/KEGG#KEGG_map00270
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200467
http://purl.org/obo/owl/IMR#IMR_0200467
IMR:0200220
http://purl.org/obo/owl/IMR#IMR_0200220
ADP-ribose + H2O => AMP + D-Ribose 5-phosphate( EC:3.6.1.13 )
ADP-5-ribose + H2O => AMP + D-Ribose 5-phosphate( EC:3.6.1.13 )
event
IMR:0200060
http://purl.org/obo/owl/IMR#IMR_0200060
IMR:0200134
http://purl.org/obo/owl/IMR#IMR_0200134
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:R01054
http://purl.org/obo/owl/KEGG#KEGG_R01054
EC:3.6.1.13
http://purl.org/obo/owl/EC#EC_3.6.1.13
ATP + Glycine + tRNA(Gly) => AMP + Glycyl-tRNA(Gly) + Pyrophosphate( EC:6.1.1.14 )
event
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200215
http://purl.org/obo/owl/IMR#IMR_0200215
KEGG:map00970
http://purl.org/obo/owl/KEGG#KEGG_map00970
IMR:0200433
http://purl.org/obo/owl/IMR#IMR_0200433
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0100118
http://purl.org/obo/owl/IMR#IMR_0100118
KEGG:R03654
http://purl.org/obo/owl/KEGG#KEGG_R03654
EC:6.1.1.14
http://purl.org/obo/owl/EC#EC_6.1.1.14
Deoxy-adenosine + H2O => Deoxy-inosine + NH3( EC:3.5.4.4 )
event
IMR:0200197
http://purl.org/obo/owl/IMR#IMR_0200197
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
EC:3.5.4.4
http://purl.org/obo/owl/EC#EC_3.5.4.4
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:R02556
http://purl.org/obo/owl/KEGG#KEGG_R02556
IMR:0200226
http://purl.org/obo/owl/IMR#IMR_0200226
ATP + XMP + L-Glutamine + H2O => AMP + GMP + L-Glutamic acid + Pyrophosphate( EC:6.3.5.2 )
event
KEGG:R01231
http://purl.org/obo/owl/KEGG#KEGG_R01231
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
EC:6.3.5.2
http://purl.org/obo/owl/EC#EC_6.3.5.2
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0200165
http://purl.org/obo/owl/IMR#IMR_0200165
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200448
http://purl.org/obo/owl/IMR#IMR_0200448
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200292
http://purl.org/obo/owl/IMR#IMR_0200292
Tyramine + H2O + O2 => 4-Hydroxy-phenyl-acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
event
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
EC:1.4.3.4
http://purl.org/obo/owl/EC#EC_1.4.3.4
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
IMR:0200040
http://purl.org/obo/owl/IMR#IMR_0200040
IMR:0100124
http://purl.org/obo/owl/IMR#IMR_0100124
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
KEGG:R02382
http://purl.org/obo/owl/KEGG#KEGG_R02382
2 NADPH + 6-Pyruvoyltetrahydropterin + 2 H+ => 2 NADP+ + Tetrahydrobiopterin( EC:1.1.1.153 )
2 NADPH + 6-Pyruvoyl-5,6,7,8-tetrahydro-pterin => 2 NADP+ + 5,6,7,8-Tetrahydro-biopterin( EC:1.1.1.153 ):multi-step reaction
event
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200209
http://purl.org/obo/owl/IMR#IMR_0200209
KEGG:R08208
http://purl.org/obo/owl/KEGG#KEGG_R08208
EC:1.1.1.153
http://purl.org/obo/owl/EC#EC_1.1.1.153
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200063
http://purl.org/obo/owl/IMR#IMR_0200063
(S)-3-Hydroxy-3-methyl-glutaryl-CoA + CoA => Acetyl-CoA + Acetoacetyl-CoA + H2O( EC:2.3.3.10 )
event
KEGG:R01978
http://purl.org/obo/owl/KEGG#KEGG_R01978
KEGG:map00900
http://purl.org/obo/owl/KEGG#KEGG_map00900
KEGG:map00650
http://purl.org/obo/owl/KEGG#KEGG_map00650
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
IMR:0200414
http://purl.org/obo/owl/IMR#IMR_0200414
KEGG:map00072
http://purl.org/obo/owl/KEGG#KEGG_map00072
EC:2.3.3.10
http://purl.org/obo/owl/EC#EC_2.3.3.10
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
IMR:0200033
http://purl.org/obo/owl/IMR#IMR_0200033
IMR:0200410
http://purl.org/obo/owl/IMR#IMR_0200410
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
2 3-Hydroxy-anthranilic acid + 4 O2 = Cinnavalininate + 2 O2.- + 2 H2O2 + 2 H+( EC:1.11.1.6 )
2 3-Hydroxy-anthranilic acid => Cinnavalininic acid( EC:1.11.1.6 ):nnon-enzymaticnmulti-step reactionnthis reaction is hastened by superoxide dismutase (ec 1.15.1.1) andncatalase (ec 1.11.1.6)
event
IMR:0200381
http://purl.org/obo/owl/IMR#IMR_0200381
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
KEGG:C00704
http://purl.org/obo/owl/KEGG#KEGG_C00704
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
IMR:0200400
http://purl.org/obo/owl/IMR#IMR_0200400
EC:1.11.1.6
http://purl.org/obo/owl/EC#EC_1.11.1.6
KEGG:R02670
http://purl.org/obo/owl/KEGG#KEGG_R02670
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
Lipoylprotein + Glycine => S-Aminomethyl-dihydro-lipoylprotein + CO2( EC:1.4.4.2 )
event
IMR:0200336
http://purl.org/obo/owl/IMR#IMR_0200336
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
EC:1.4.4.2
http://purl.org/obo/owl/EC#EC_1.4.4.2
IMR:0200377
http://purl.org/obo/owl/IMR#IMR_0200377
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
KEGG:R03425
http://purl.org/obo/owl/KEGG#KEGG_R03425
IMR:0100118
http://purl.org/obo/owl/IMR#IMR_0100118
CMP + H2O => Cytidine + Orthophosphate( EC:3.1.3.5 )
event
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200161
http://purl.org/obo/owl/IMR#IMR_0200161
EC:3.1.3.5
http://purl.org/obo/owl/EC#EC_3.1.3.5
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:R00511
http://purl.org/obo/owl/KEGG#KEGG_R00511
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0200494
http://purl.org/obo/owl/IMR#IMR_0200494
2-Amino-3-carboxy-muconate semialdehyde => 2,3-Pyridine-dicarboxylic acid + H2O( nonenzymatic )
event
KEGG:R04293
http://purl.org/obo/owl/KEGG#KEGG_R04293
IMR:0200460
http://purl.org/obo/owl/IMR#IMR_0200460
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200192
http://purl.org/obo/owl/IMR#IMR_0200192
NAD+ + Acetaldehyde + H2O = NADH + Acetic acid + H+( EC:1.2.1.3 )
NAD+ + Acetaldehyde + H2O = NADH + Acetic acid( EC:1.2.1.3 )
event
EC:1.2.1.3
http://purl.org/obo/owl/EC#EC_1.2.1.3
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200208
http://purl.org/obo/owl/IMR#IMR_0200208
IMR:0200373
http://purl.org/obo/owl/IMR#IMR_0200373
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:R00710
http://purl.org/obo/owl/KEGG#KEGG_R00710
KEGG:map00620
http://purl.org/obo/owl/KEGG#KEGG_map00620
ATP + Nucleoside diphosphate = ADP + Nucleoside triphosphate( EC:2.7.4.6 )
general reaction
event
EC:2.7.4.6
http://purl.org/obo/owl/EC#EC_2.7.4.6
KEGG:R00331
http://purl.org/obo/owl/KEGG#KEGG_R00331
KEGG:C00454
http://purl.org/obo/owl/KEGG#KEGG_C00454
IMR:0200499
http://purl.org/obo/owl/IMR#IMR_0200499
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O => 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate + Orthophosphate ( EC:3.1.3.67 )
event
IMR:0001352
http://purl.org/obo/owl/IMR#IMR_0001352
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
KEGG:R04513
http://purl.org/obo/owl/KEGG#KEGG_R04513
IMR:0001350
http://purl.org/obo/owl/IMR#IMR_0001350
KEGG:map04070
http://purl.org/obo/owl/KEGG#KEGG_map04070
EC:3.1.3.67
http://purl.org/obo/owl/EC#EC_3.1.3.67
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
beta-D-Fructose 1,6-bisphosphate = Dihydroxy-acetone phosphate + D-Glyceraldehyde 3-phosphate( EC:4.1.2.13 )
D-Fructose 1,6-bisphosphate = Dihydroxy-acetone phosphate + D-Glyceraldehyde 3-phosphate( EC:4.1.2.13 )
event
KEGG:map00030
http://purl.org/obo/owl/KEGG#KEGG_map00030
KEGG:C05378
http://purl.org/obo/owl/KEGG#KEGG_C05378
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
EC:4.1.2.13
http://purl.org/obo/owl/EC#EC_4.1.2.13
IMR:0200058
http://purl.org/obo/owl/IMR#IMR_0200058
KEGG:map00051
http://purl.org/obo/owl/KEGG#KEGG_map00051
KEGG:R01070
http://purl.org/obo/owl/KEGG#KEGG_R01070
IMR:0200100
http://purl.org/obo/owl/IMR#IMR_0200100
Succinyl-CoA + Enzyme N6-(dihydrolipoyl)lysine = CoA + [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine( EC:2.3.1.61 )
Succinyl-CoA + Dihydro-lipoamide = CoA + S-Succinyl-dihydro-lipoamide( EC:2.3.1.61 )
IEV:0002740
event
KEGG:C15973
http://purl.org/obo/owl/KEGG#KEGG_C15973
IMR:0200037
http://purl.org/obo/owl/IMR#IMR_0200037
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
EC:2.3.1.61
http://purl.org/obo/owl/EC#EC_2.3.1.61
KEGG:R02570
http://purl.org/obo/owl/KEGG#KEGG_R02570
KEGG:map00020
http://purl.org/obo/owl/KEGG#KEGG_map00020
KEGG:C16254
http://purl.org/obo/owl/KEGG#KEGG_C16254
Succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine( EC:2.3.1.61 )
NAD+ + (S)-Malic acid = NADH + Pyruvic acid + CO2 + H+( EC:1.1.1.38 )
NAD+ + (S)-Malic acid = NADH + Pyruvic acid + CO2( EC:1.1.1.38 )
event
KEGG:map00620
http://purl.org/obo/owl/KEGG#KEGG_map00620
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:R00214
http://purl.org/obo/owl/KEGG#KEGG_R00214
KEGG:map00710
http://purl.org/obo/owl/KEGG#KEGG_map00710
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.1.1.38
http://purl.org/obo/owl/EC#EC_1.1.1.38
IMR:0200331
http://purl.org/obo/owl/IMR#IMR_0200331
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200278
http://purl.org/obo/owl/IMR#IMR_0200278
(S)-2-Methylbutanoyl-CoA + Acceptor = 2-Methylbut-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.3 )
2-Methyl-butanoyl-CoA + Acceptor = 2-Methylbut-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.3 )
event
KEGG:R03172
http://purl.org/obo/owl/KEGG#KEGG_R03172
IMR:0200224
http://purl.org/obo/owl/IMR#IMR_0200224
EC:1.3.99.3
http://purl.org/obo/owl/EC#EC_1.3.99.3
IMR:0200465
http://purl.org/obo/owl/IMR#IMR_0200465
IMR:0200300
http://purl.org/obo/owl/IMR#IMR_0200300
KEGG:C15980
http://purl.org/obo/owl/KEGG#KEGG_C15980
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
ATP + L-Alanine + tRNA(Ala) => AMP + L-Alanyl-tRNA(Ala) + Pyrophosphate( EC:6.1.1.7 )
event
KEGG:R03038
http://purl.org/obo/owl/KEGG#KEGG_R03038
EC:6.1.1.7
http://purl.org/obo/owl/EC#EC_6.1.1.7
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0200095
http://purl.org/obo/owl/IMR#IMR_0200095
IMR:0200244
http://purl.org/obo/owl/IMR#IMR_0200244
KEGG:map00970
http://purl.org/obo/owl/KEGG#KEGG_map00970
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200251
http://purl.org/obo/owl/IMR#IMR_0200251
2-Amino-3-carboxy-muconate semialdehyde => 2-Amino-muconate semialdehyde + CO2( EC:4.1.1.45 )
event
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200192
http://purl.org/obo/owl/IMR#IMR_0200192
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
IMR:0200424
http://purl.org/obo/owl/IMR#IMR_0200424
EC:4.1.1.45
http://purl.org/obo/owl/EC#EC_4.1.1.45
KEGG:R04323
http://purl.org/obo/owl/KEGG#KEGG_R04323
L-Serine => 2-Amino-acrylic acid + H2O( EC:4.3.1.17 )
event
KEGG:map00270
http://purl.org/obo/owl/KEGG#KEGG_map00270
KEGG:R00590
http://purl.org/obo/owl/KEGG#KEGG_R00590
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200453
http://purl.org/obo/owl/IMR#IMR_0200453
EC:4.3.1.17
http://purl.org/obo/owl/EC#EC_4.3.1.17
IMR:0200090
http://purl.org/obo/owl/IMR#IMR_0200090
5-Hydroxy-L-tryptophan => Serotonin + CO2( EC:4.1.1.28 )
event
EC:4.1.1.28
http://purl.org/obo/owl/EC#EC_4.1.1.28
IMR:0100123
http://purl.org/obo/owl/IMR#IMR_0100123
IMR:0200112
http://purl.org/obo/owl/IMR#IMR_0200112
KEGG:R02701
http://purl.org/obo/owl/KEGG#KEGG_R02701
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
5(S)-HPETE => Leukotriene A4 + H2O( EC:1.13.11.34 )
5-HPETE => Leucotriene A4 + H2O( EC:1.13.11.34 )
event
IMR:0200275
http://purl.org/obo/owl/IMR#IMR_0200275
EC:1.13.11.34
http://purl.org/obo/owl/EC#EC_1.13.11.34
IMR:0200461
http://purl.org/obo/owl/IMR#IMR_0200461
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:R03058
http://purl.org/obo/owl/KEGG#KEGG_R03058
KEGG:map00590
http://purl.org/obo/owl/KEGG#KEGG_map00590
1D-myo-Inositol 1-phosphate + H2O => myo-Inositol + Orthophosphate( EC:3.1.3.25 )
event
KEGG:R01185
http://purl.org/obo/owl/KEGG#KEGG_R01185
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
KEGG:map04070
http://purl.org/obo/owl/KEGG#KEGG_map04070
EC:3.1.3.25
http://purl.org/obo/owl/EC#EC_3.1.3.25
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200177
http://purl.org/obo/owl/IMR#IMR_0200177
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200476
http://purl.org/obo/owl/IMR#IMR_0200476
2-Oxo-glutaric acid + L-Ornithine = L-Glutamic acid + L-Glutamate 5-semialdehyde( EC:2.6.1.13 )
2-Oxo-glutaric acid + N2-Succinyl-L-ornithine = L-Glutamic acid + N2-Succinyl-L-glutamate 5-semialdehyde( EC:2.6.1.13 )
event
EC:2.6.1.13
http://purl.org/obo/owl/EC#EC_2.6.1.13
KEGG:R00667
http://purl.org/obo/owl/KEGG#KEGG_R00667
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
IMR:0200205
http://purl.org/obo/owl/IMR#IMR_0200205
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
IMR:0200342
http://purl.org/obo/owl/IMR#IMR_0200342
S-Adenosyl-L-methionine + 3,4-Dihydroxy-mandelic acid => S-Adenosyl-L-homocysteine + 3-Methoxy-4-hydroxy-mandelic acid( EC:2.1.1.6 )
event
IMR:0200068
http://purl.org/obo/owl/IMR#IMR_0200068
IMR:0200151
http://purl.org/obo/owl/IMR#IMR_0200151
IMR:0200152
http://purl.org/obo/owl/IMR#IMR_0200152
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
KEGG:R04887
http://purl.org/obo/owl/KEGG#KEGG_R04887
IMR:0200054
http://purl.org/obo/owl/IMR#IMR_0200054
EC:2.1.1.6
http://purl.org/obo/owl/EC#EC_2.1.1.6
Adenylo-succinic acid = AMP + Fumaric acid( EC:4.3.2.2 )
event
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200186
http://purl.org/obo/owl/IMR#IMR_0200186
IMR:0200115
http://purl.org/obo/owl/IMR#IMR_0200115
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
EC:4.3.2.2
http://purl.org/obo/owl/EC#EC_4.3.2.2
KEGG:R01083
http://purl.org/obo/owl/KEGG#KEGG_R01083
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
5'-Phospho-ribosyl-4-(N-succino-carboxamide)-5-amino-imidazole = 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + Fumaric acid( EC:4.3.2.2 )
5'-Phospho-ribosyl-4-(N-succino-carboxamide)-5-amino-imidazole = 5'-Phospho-ribosyl-4-carboxamido-5-amino-imidazole + Fumaric acid( EC:4.3.2.2 )
event
IMR:0200284
http://purl.org/obo/owl/IMR#IMR_0200284
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
EC:4.3.2.2
http://purl.org/obo/owl/EC#EC_4.3.2.2
IMR:0200213
http://purl.org/obo/owl/IMR#IMR_0200213
IMR:0200186
http://purl.org/obo/owl/IMR#IMR_0200186
KEGG:R04559
http://purl.org/obo/owl/KEGG#KEGG_R04559
3-Hydroxy-L-kynurenine + H2O => 3-Hydroxy-anthranilic acid + L-Alanine( EC:3.7.1.3 )
event
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
IMR:0200400
http://purl.org/obo/owl/IMR#IMR_0200400
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200251
http://purl.org/obo/owl/IMR#IMR_0200251
IMR:0200066
http://purl.org/obo/owl/IMR#IMR_0200066
EC:3.7.1.3
http://purl.org/obo/owl/EC#EC_3.7.1.3
KEGG:R02668
http://purl.org/obo/owl/KEGG#KEGG_R02668
UTP + AMP = UDP + ADP( EC:2.7.4.10 )
event
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0200199
http://purl.org/obo/owl/IMR#IMR_0200199
EC:2.7.4.10
http://purl.org/obo/owl/EC#EC_2.7.4.10
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
KEGG:R00157
http://purl.org/obo/owl/KEGG#KEGG_R00157
IMR:0200206
http://purl.org/obo/owl/IMR#IMR_0200206
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
Arachidonic acid + O2 => 15(S)-HPETE( EC:1.13.11.33 )
Arachidonic acid + O2 => 15-HPETE( EC:1.13.11.33 )
event
KEGG:R01593
http://purl.org/obo/owl/KEGG#KEGG_R01593
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200212
http://purl.org/obo/owl/IMR#IMR_0200212
KEGG:map00590
http://purl.org/obo/owl/KEGG#KEGG_map00590
EC:1.13.11.33
http://purl.org/obo/owl/EC#EC_1.13.11.33
IMR:0200351
http://purl.org/obo/owl/IMR#IMR_0200351
1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O => 1-Phosphatidyl-1D-myo-inositol 4 phosphate + Orthophosphate( EC:3.1.3.36 )
event
IMR:0001350
http://purl.org/obo/owl/IMR#IMR_0001350
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200496
http://purl.org/obo/owl/IMR#IMR_0200496
KEGG:map04070
http://purl.org/obo/owl/KEGG#KEGG_map04070
KEGG:R04404
http://purl.org/obo/owl/KEGG#KEGG_R04404
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
EC:3.1.3.36
http://purl.org/obo/owl/EC#EC_3.1.3.36
NAD+ + (S)-Malic acid = NADH + Oxaloacetic acid + H+( EC:1.1.1.37 )
NAD+ + (S)-Malic acid = NADH + Oxaloacetic acid( EC:1.1.1.37 )
event
KEGG:R00342
http://purl.org/obo/owl/KEGG#KEGG_R00342
KEGG:map00720
http://purl.org/obo/owl/KEGG#KEGG_map00720
KEGG:map00710
http://purl.org/obo/owl/KEGG#KEGG_map00710
KEGG:map00630
http://purl.org/obo/owl/KEGG#KEGG_map00630
KEGG:map00620
http://purl.org/obo/owl/KEGG#KEGG_map00620
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
KEGG:map00020
http://purl.org/obo/owl/KEGG#KEGG_map00020
EC:1.1.1.37
http://purl.org/obo/owl/EC#EC_1.1.1.37
IMR:0200339
http://purl.org/obo/owl/IMR#IMR_0200339
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200278
http://purl.org/obo/owl/IMR#IMR_0200278
ATP + Deoxy-cytidine => ADP + dCMP( EC:2.7.1.74 )
event
KEGG:R01666
http://purl.org/obo/owl/KEGG#KEGG_R01666
IMR:0200005
http://purl.org/obo/owl/IMR#IMR_0200005
IMR:0200390
http://purl.org/obo/owl/IMR#IMR_0200390
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
EC:2.7.1.74
http://purl.org/obo/owl/EC#EC_2.7.1.74
L-Homocysteine + Betaine => L-Methionine + N,N-Dimethyl-glycine( EC:2.1.1.5 )
event
IMR:0200488
http://purl.org/obo/owl/IMR#IMR_0200488
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
KEGG:map00270
http://purl.org/obo/owl/KEGG#KEGG_map00270
IMR:0200233
http://purl.org/obo/owl/IMR#IMR_0200233
IMR:0200047
http://purl.org/obo/owl/IMR#IMR_0200047
IMR:0200039
http://purl.org/obo/owl/IMR#IMR_0200039
EC:2.1.1.5
http://purl.org/obo/owl/EC#EC_2.1.1.5
KEGG:R02821
http://purl.org/obo/owl/KEGG#KEGG_R02821
L-Arginine + H2O => L-Ornithine + Urea( EC:3.5.3.1 )
event
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200342
http://purl.org/obo/owl/IMR#IMR_0200342
IMR:0200111
http://purl.org/obo/owl/IMR#IMR_0200111
EC:3.5.3.1
http://purl.org/obo/owl/EC#EC_3.5.3.1
KEGG:R00551
http://purl.org/obo/owl/KEGG#KEGG_R00551
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
IMR:0200428
http://purl.org/obo/owl/IMR#IMR_0200428
beta-D-Glucose 6-phosphate = beta-D-Fructose 6-phosphate( EC:5.3.1.9 )
D-Glucose 6-phosphate = D-Fructose 6-phosphate( EC:5.3.1.9 )
event
KEGG:C01172
http://purl.org/obo/owl/KEGG#KEGG_C01172
EC:5.3.1.9
http://purl.org/obo/owl/EC#EC_5.3.1.9
KEGG:R03321
http://purl.org/obo/owl/KEGG#KEGG_R03321
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
KEGG:C05345
http://purl.org/obo/owl/KEGG#KEGG_C05345
(S)-2-Methylbutanoyl-CoA + Acceptor = 2-Methylbut-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.2 )
2-Methyl-butanoyl-CoA + Acceptor = 2-Methylbut-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.2 )
event
IMR:0200300
http://purl.org/obo/owl/IMR#IMR_0200300
IMR:0200465
http://purl.org/obo/owl/IMR#IMR_0200465
KEGG:C15980
http://purl.org/obo/owl/KEGG#KEGG_C15980
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
KEGG:R03172
http://purl.org/obo/owl/KEGG#KEGG_R03172
EC:1.3.99.2
http://purl.org/obo/owl/EC#EC_1.3.99.2
IMR:0200224
http://purl.org/obo/owl/IMR#IMR_0200224
NAD+ + L-Saccharopine + H2O = NADH + L-2-Amino-adipate 6-semialdehyde + L-Glutamic acid + H+( EC:1.5.1.9 )
NAD+ + L-Saccharopine + H2O = NADH + L-2-Amino-adipate 6-semialdehyde + L-Glutamic acid( EC:1.5.1.9 )
event
KEGG:R02313
http://purl.org/obo/owl/KEGG#KEGG_R02313
KEGG:map00310
http://purl.org/obo/owl/KEGG#KEGG_map00310
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
EC:1.5.1.9
http://purl.org/obo/owl/EC#EC_1.5.1.9
IMR:0200294
http://purl.org/obo/owl/IMR#IMR_0200294
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200155
http://purl.org/obo/owl/IMR#IMR_0200155
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
Squalene + O2 + NADPH + H+ => (S)-2,3-Epoxy-squalene + H2O + NADP+( EC:1.14.99.7 )
Squalene + O2 + Reduced acceptor => (S)-2,3-Epoxy-squalene + H2O + Acceptor( EC:1.14.99.7 )
event
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
EC:1.14.99.7
http://purl.org/obo/owl/EC#EC_1.14.99.7
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200481
http://purl.org/obo/owl/IMR#IMR_0200481
IMR:0200509
http://purl.org/obo/owl/IMR#IMR_0200509
KEGG:map00100
http://purl.org/obo/owl/KEGG#KEGG_map00100
KEGG:R02874
http://purl.org/obo/owl/KEGG#KEGG_R02874
GTP => 3',5'-Cyclic GMP + Pyrophosphate( EC:4.6.1.2 )
event
EC:4.6.1.2
http://purl.org/obo/owl/EC#EC_4.6.1.2
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0100025
http://purl.org/obo/owl/IMR#IMR_0100025
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R00434
http://purl.org/obo/owl/KEGG#KEGG_R00434
D-Ribose 1-phosphate = D-Ribose 5-phosphate( EC:5.4.2.2 )
event
EC:5.4.2.2
http://purl.org/obo/owl/EC#EC_5.4.2.2
IMR:0200060
http://purl.org/obo/owl/IMR#IMR_0200060
KEGG:R01057
http://purl.org/obo/owl/KEGG#KEGG_R01057
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:C00620
http://purl.org/obo/owl/KEGG#KEGG_C00620
KEGG:map00030
http://purl.org/obo/owl/KEGG#KEGG_map00030
myo-Inositol + O2 => D-Glucuronic acid + H2O( EC:1.13.99.1 )
event
EC:1.13.99.1
http://purl.org/obo/owl/EC#EC_1.13.99.1
IMR:0200015
http://purl.org/obo/owl/IMR#IMR_0200015
KEGG:R01184
http://purl.org/obo/owl/KEGG#KEGG_R01184
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00053
http://purl.org/obo/owl/KEGG#KEGG_map00053
IMR:0200177
http://purl.org/obo/owl/IMR#IMR_0200177
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
3-Hydroxy-N6,N6,N6-trimethyl-L-lysine => 4-Trimethyl-ammonio-butanal + Glycine( EC:4.1.2.- )
3-Hydroxy-N6,N6,N6-trimethyl-L-lysine => 4-Trimethyl-ammonio-butanal + Glycine( EC:2.1.2.1 )
event
KEGG:R03284
http://purl.org/obo/owl/KEGG#KEGG_R03284
KEGG:map00310
http://purl.org/obo/owl/KEGG#KEGG_map00310
IMR:0200493
http://purl.org/obo/owl/IMR#IMR_0200493
EC:4.1.2.-
http://purl.org/obo/owl/EC#EC_4.1.2.-
IMR:0100118
http://purl.org/obo/owl/IMR#IMR_0100118
IMR:0200070
http://purl.org/obo/owl/IMR#IMR_0200070
ATP + dCMP = ADP + dCDP( EC:2.7.4.14 )
event
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200005
http://purl.org/obo/owl/IMR#IMR_0200005
IMR:0200078
http://purl.org/obo/owl/IMR#IMR_0200078
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:R01665
http://purl.org/obo/owl/KEGG#KEGG_R01665
EC:2.7.4.14
http://purl.org/obo/owl/EC#EC_2.7.4.14
Deoxy-inosine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Hypoxanthine( EC:2.4.2.4 )
event
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R02748
http://purl.org/obo/owl/KEGG#KEGG_R02748
IMR:0200173
http://purl.org/obo/owl/IMR#IMR_0200173
IMR:0200197
http://purl.org/obo/owl/IMR#IMR_0200197
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200048
http://purl.org/obo/owl/IMR#IMR_0200048
EC:2.4.2.4
http://purl.org/obo/owl/EC#EC_2.4.2.4
CoA + ATP + Succinic acid = Succinyl-CoA + ADP + Orthophosphate( EC:6.2.1.5 )
event
KEGG:R00405
http://purl.org/obo/owl/KEGG#KEGG_R00405
KEGG:map00720
http://purl.org/obo/owl/KEGG#KEGG_map00720
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
EC:6.2.1.5
http://purl.org/obo/owl/EC#EC_6.2.1.5
IMR:0200119
http://purl.org/obo/owl/IMR#IMR_0200119
KEGG:map00640
http://purl.org/obo/owl/KEGG#KEGG_map00640
KEGG:map00020
http://purl.org/obo/owl/KEGG#KEGG_map00020
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200037
http://purl.org/obo/owl/IMR#IMR_0200037
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
ATP + L-Tryptophan + tRNA(Trp) => AMP + L-Tryptophanyl-tRNA(Trp) + Pyrophosphate( EC:6.1.1.2 )
event
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:6.1.1.2
http://purl.org/obo/owl/EC#EC_6.1.1.2
IMR:0200260
http://purl.org/obo/owl/IMR#IMR_0200260
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200306
http://purl.org/obo/owl/IMR#IMR_0200306
IMR:0200307
http://purl.org/obo/owl/IMR#IMR_0200307
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
KEGG:map00970
http://purl.org/obo/owl/KEGG#KEGG_map00970
KEGG:R03664
http://purl.org/obo/owl/KEGG#KEGG_R03664
1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate = 5'-Phospho-ribosyl-5-amino-imidazole + CO2( EC:4.1.1.21 )
5'-Phospho-ribosyl-5-amino-imidazole-4-carboxylic acid = 5'-Phospho-ribosyl-5-amino-imidazole + CO2( EC:4.1.1.21 )
event
EC:4.1.1.21
http://purl.org/obo/owl/EC#EC_4.1.1.21
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
KEGG:R04209
http://purl.org/obo/owl/KEGG#KEGG_R04209
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200513
http://purl.org/obo/owl/IMR#IMR_0200513
IMR:0200422
http://purl.org/obo/owl/IMR#IMR_0200422
Choloyl-CoA + Taurine = CoA + Taurocholic acid( EC:2.3.1.65 )
event
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
IMR:0200138
http://purl.org/obo/owl/IMR#IMR_0200138
IMR:0200004
http://purl.org/obo/owl/IMR#IMR_0200004
EC:2.3.1.65
http://purl.org/obo/owl/EC#EC_2.3.1.65
IMR:0100120
http://purl.org/obo/owl/IMR#IMR_0100120
KEGG:R03720
http://purl.org/obo/owl/KEGG#KEGG_R03720
KEGG:map00120
http://purl.org/obo/owl/KEGG#KEGG_map00120
KEGG:map00430
http://purl.org/obo/owl/KEGG#KEGG_map00430
NAD+ + L-Glutamic acid + H2O = NADH + 2-Oxo-glutaric acid + NH3 + H+( EC:1.4.1.3 )
NAD+ + L-Glutamic acid + H2O = NADH + 2-Oxo-glutaric acid + NH3( EC:1.4.1.3 )
event
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
KEGG:map00910
http://purl.org/obo/owl/KEGG#KEGG_map00910
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
KEGG:map00471
http://purl.org/obo/owl/KEGG#KEGG_map00471
EC:1.4.1.3
http://purl.org/obo/owl/EC#EC_1.4.1.3
KEGG:R00243
http://purl.org/obo/owl/KEGG#KEGG_R00243
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
D-Fructose 1-phosphate = Dihydroxy-acetone phosphate + D-Glyceraldehyde( EC:4.1.2.13 )
event
EC:4.1.2.13
http://purl.org/obo/owl/EC#EC_4.1.2.13
IMR:0200120
http://purl.org/obo/owl/IMR#IMR_0200120
IMR:0200100
http://purl.org/obo/owl/IMR#IMR_0200100
KEGG:map00051
http://purl.org/obo/owl/KEGG#KEGG_map00051
IMR:0200167
http://purl.org/obo/owl/IMR#IMR_0200167
KEGG:R02568
http://purl.org/obo/owl/KEGG#KEGG_R02568
D-Glucose 1-phosphate = alpha-D-Glucose 6-phosphate( EC:5.4.2.2 )
D-Glucose 1-phosphate = D-Glucose 6-phosphate( EC:5.4.2.2 )
event
KEGG:C00668
http://purl.org/obo/owl/KEGG#KEGG_C00668
IMR:0200190
http://purl.org/obo/owl/IMR#IMR_0200190
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
EC:5.4.2.2
http://purl.org/obo/owl/EC#EC_5.4.2.2
KEGG:map00052
http://purl.org/obo/owl/KEGG#KEGG_map00052
KEGG:map00500
http://purl.org/obo/owl/KEGG#KEGG_map00500
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
KEGG:R00959
http://purl.org/obo/owl/KEGG#KEGG_R00959
NAD+ + 3-Methoxy-4-hydroxy-phenyl-glycolaldehyde + H2O = NADH + 3-Methoxy-4-hydroxy-mandelic acid + H+( EC:1.2.1.5 )
NAD+ + 3-Methoxy-4-hydroxy-phenyl-glycolaldehyde + H2O = NADH + 3-Methoxy-4-hydroxy-mandelic acid( EC:1.2.1.5 )
event
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200171
http://purl.org/obo/owl/IMR#IMR_0200171
EC:1.2.1.5
http://purl.org/obo/owl/EC#EC_1.2.1.5
IMR:0200152
http://purl.org/obo/owl/IMR#IMR_0200152
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
KEGG:R04891
http://purl.org/obo/owl/KEGG#KEGG_R04891
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
1D-myo-Inositol 1,4-bisphosphate + H2O => 1D-myo-Inositol 4-phosphate + Orthophosphate( EC:3.1.3.57 )
event
EC:3.1.3.57
http://purl.org/obo/owl/EC#EC_3.1.3.57
IMR:0100698
http://purl.org/obo/owl/IMR#IMR_0100698
KEGG:R03393
http://purl.org/obo/owl/KEGG#KEGG_R03393
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
KEGG:map04070
http://purl.org/obo/owl/KEGG#KEGG_map04070
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200419
http://purl.org/obo/owl/IMR#IMR_0200419
2-Oxo acid + L-Ornithine = L-Amino acid + L-Glutamate 5-semialdehyde( EC:2.6.1.13 )
event
IMR:0200205
http://purl.org/obo/owl/IMR#IMR_0200205
IMR:0200342
http://purl.org/obo/owl/IMR#IMR_0200342
EC:2.6.1.13
http://purl.org/obo/owl/EC#EC_2.6.1.13
KEGG:R01343
http://purl.org/obo/owl/KEGG#KEGG_R01343
KEGG:C00151
http://purl.org/obo/owl/KEGG#KEGG_C00151
KEGG:C00161
http://purl.org/obo/owl/KEGG#KEGG_C00161
L-Normetanephrine + H2O + O2 => 3-Methoxy-4-hydroxy-phenyl-glycolaldehyde + NH3 + H2O2( EC:1.4.3.4 )
event
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200388
http://purl.org/obo/owl/IMR#IMR_0200388
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
EC:1.4.3.4
http://purl.org/obo/owl/EC#EC_1.4.3.4
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0200171
http://purl.org/obo/owl/IMR#IMR_0200171
KEGG:R04893
http://purl.org/obo/owl/KEGG#KEGG_R04893
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
ATP + CDP = ADP + CTP( EC:2.7.4.6 )
event
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:2.7.4.6
http://purl.org/obo/owl/EC#EC_2.7.4.6
KEGG:R00570
http://purl.org/obo/owl/KEGG#KEGG_R00570
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0200468
http://purl.org/obo/owl/IMR#IMR_0200468
IMR:0200202
http://purl.org/obo/owl/IMR#IMR_0200202
(S)-3-Hydroxy-3-methyl-glutaryl-CoA = 3-Methyl-glutaconyl-CoA + H2O( EC:4.2.1.18 )
event
IMR:0200069
http://purl.org/obo/owl/IMR#IMR_0200069
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
KEGG:R02085
http://purl.org/obo/owl/KEGG#KEGG_R02085
IMR:0200033
http://purl.org/obo/owl/IMR#IMR_0200033
EC:4.2.1.18
http://purl.org/obo/owl/EC#EC_4.2.1.18
4-Fumaryl-acetoacetic acid + H2O => Fumaric acid + Acetoacetic acid( EC:3.7.1.2 )
event
IMR:0200186
http://purl.org/obo/owl/IMR#IMR_0200186
IMR:0200064
http://purl.org/obo/owl/IMR#IMR_0200064
IMR:0200507
http://purl.org/obo/owl/IMR#IMR_0200507
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:R01364
http://purl.org/obo/owl/KEGG#KEGG_R01364
KEGG:map00643
http://purl.org/obo/owl/KEGG#KEGG_map00643
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
EC:3.7.1.2
http://purl.org/obo/owl/EC#EC_3.7.1.2
beta-D-Fructose 1,6-bisphosphate + H2O => beta-D-Fructose 6-phosphate + Orthophosphate( EC:3.1.3.11 )
D-Fructose 1,6-bisphosphate + H2O => D-Fructose 6-phosphate + Orthophosphate( EC:3.1.3.11 )
event
KEGG:map00030
http://purl.org/obo/owl/KEGG#KEGG_map00030
KEGG:R04780
http://purl.org/obo/owl/KEGG#KEGG_R04780
KEGG:map00051
http://purl.org/obo/owl/KEGG#KEGG_map00051
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:C05345
http://purl.org/obo/owl/KEGG#KEGG_C05345
KEGG:C05378
http://purl.org/obo/owl/KEGG#KEGG_C05378
EC:3.1.3.11
http://purl.org/obo/owl/EC#EC_3.1.3.11
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
N-Acetyl-D-glucosamine = N-Acetyl-D-mannosamine( EC:5.1.3.8 )
event
IMR:0200282
http://purl.org/obo/owl/IMR#IMR_0200282
IMR:0200374
http://purl.org/obo/owl/IMR#IMR_0200374
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
KEGG:R01207
http://purl.org/obo/owl/KEGG#KEGG_R01207
EC:5.1.3.8
http://purl.org/obo/owl/EC#EC_5.1.3.8
GDP + H2O => GMP + Orthophosphate( EC:3.6.1.5 )
event
KEGG:R00328
http://purl.org/obo/owl/KEGG#KEGG_R00328
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200292
http://purl.org/obo/owl/IMR#IMR_0200292
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
EC:3.6.1.5
http://purl.org/obo/owl/EC#EC_3.6.1.5
IDP + H2O => IMP + Orthophosphate( EC:3.6.1.6 )
event
EC:3.6.1.6
http://purl.org/obo/owl/EC#EC_3.6.1.6
IMR:0200221
http://purl.org/obo/owl/IMR#IMR_0200221
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
KEGG:R00961
http://purl.org/obo/owl/KEGG#KEGG_R00961
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200511
http://purl.org/obo/owl/IMR#IMR_0200511
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
ATP + Sulfuric acid => Adenosine-5'-phospho-sulfate + Pyrophosphate( EC:2.7.7.4 )
event
IMR:0200032
http://purl.org/obo/owl/IMR#IMR_0200032
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0200232
http://purl.org/obo/owl/IMR#IMR_0200232
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R00529
http://purl.org/obo/owl/KEGG#KEGG_R00529
EC:2.7.7.4
http://purl.org/obo/owl/EC#EC_2.7.7.4
UTP + N-Acetyl-alpha-D-glucosamine 1-phosphate = Pyrophosphate + UDP-N-acetyl-D-glucosamine( EC:2.7.7.23 )
UTP + N-Acetyl-D-glucosamine 1-phosphate = Pyrophosphate + UDP-N-acetyl-D-glucosamine( EC:2.7.7.23 )
event
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
KEGG:R00416
http://purl.org/obo/owl/KEGG#KEGG_R00416
KEGG:C04501
http://purl.org/obo/owl/KEGG#KEGG_C04501
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200247
http://purl.org/obo/owl/IMR#IMR_0200247
IMR:0200199
http://purl.org/obo/owl/IMR#IMR_0200199
EC:2.7.7.23
http://purl.org/obo/owl/EC#EC_2.7.7.23
2 Acetyl-CoA = CoA + Acetoacetyl-CoA( EC:2.3.1.9 )
event
KEGG:map00310
http://purl.org/obo/owl/KEGG#KEGG_map00310
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
EC:2.3.1.9
http://purl.org/obo/owl/EC#EC_2.3.1.9
KEGG:map00620
http://purl.org/obo/owl/KEGG#KEGG_map00620
KEGG:map00632
http://purl.org/obo/owl/KEGG#KEGG_map00632
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
KEGG:map00640
http://purl.org/obo/owl/KEGG#KEGG_map00640
KEGG:map00650
http://purl.org/obo/owl/KEGG#KEGG_map00650
KEGG:map00071
http://purl.org/obo/owl/KEGG#KEGG_map00071
KEGG:map00900
http://purl.org/obo/owl/KEGG#KEGG_map00900
KEGG:R00238
http://purl.org/obo/owl/KEGG#KEGG_R00238
KEGG:map00072
http://purl.org/obo/owl/KEGG#KEGG_map00072
IMR:0200410
http://purl.org/obo/owl/IMR#IMR_0200410
IMR:0200414
http://purl.org/obo/owl/IMR#IMR_0200414
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
Malonyl-CoA = Acetyl-CoA + CO2( EC:4.1.1.9 )
event
IMR:0200464
http://purl.org/obo/owl/IMR#IMR_0200464
KEGG:map00410
http://purl.org/obo/owl/KEGG#KEGG_map00410
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200414
http://purl.org/obo/owl/IMR#IMR_0200414
EC:4.1.1.9
http://purl.org/obo/owl/EC#EC_4.1.1.9
KEGG:R00233
http://purl.org/obo/owl/KEGG#KEGG_R00233
KEGG:map00640
http://purl.org/obo/owl/KEGG#KEGG_map00640
GTP + IMP + L-Aspartic acid => GDP + Adenylo-succinic acid + Orthophosphate( EC:6.3.4.4 )
event
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R01135
http://purl.org/obo/owl/KEGG#KEGG_R01135
IMR:0200115
http://purl.org/obo/owl/IMR#IMR_0200115
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200459
http://purl.org/obo/owl/IMR#IMR_0200459
IMR:0200221
http://purl.org/obo/owl/IMR#IMR_0200221
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
EC:6.3.4.4
http://purl.org/obo/owl/EC#EC_6.3.4.4
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
ADP + Reduced thioredoxin => dADP + H2O + Oxidized thioredoxin( EC:1.17.4.1 )
event
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:R02017
http://purl.org/obo/owl/KEGG#KEGG_R02017
EC:1.17.4.1
http://purl.org/obo/owl/EC#EC_1.17.4.1
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200108
http://purl.org/obo/owl/IMR#IMR_0200108
IMR:0200133
http://purl.org/obo/owl/IMR#IMR_0200133
IMR:0200237
http://purl.org/obo/owl/IMR#IMR_0200237
ATP + dUMP = ADP + dUDP( EC:2.7.4.9 )
event
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0200098
http://purl.org/obo/owl/IMR#IMR_0200098
IMR:0200008
http://purl.org/obo/owl/IMR#IMR_0200008
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:2.7.4.9
http://purl.org/obo/owl/EC#EC_2.7.4.9
KEGG:R02098
http://purl.org/obo/owl/KEGG#KEGG_R02098
Thymidine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Thymine( EC:2.4.2.4 )
event
EC:2.4.2.4
http://purl.org/obo/owl/EC#EC_2.4.2.4
IMR:0200036
http://purl.org/obo/owl/IMR#IMR_0200036
IMR:0200048
http://purl.org/obo/owl/IMR#IMR_0200048
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
KEGG:R01570
http://purl.org/obo/owl/KEGG#KEGG_R01570
IMR:0200384
http://purl.org/obo/owl/IMR#IMR_0200384
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
Arachidonic acid + O2 => 5(S)-HPETE( EC:1.13.11.34 )
Arachidonic acid + O2 => 5-HPETE( EC:1.13.11.34 ):subsequently IEV:0002918
event
IMR:0200212
http://purl.org/obo/owl/IMR#IMR_0200212
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
EC:1.13.11.34
http://purl.org/obo/owl/EC#EC_1.13.11.34
IMR:0200275
http://purl.org/obo/owl/IMR#IMR_0200275
KEGG:map00590
http://purl.org/obo/owl/KEGG#KEGG_map00590
KEGG:R01595
http://purl.org/obo/owl/KEGG#KEGG_R01595
ITP + H2O => IMP + Pyrophosphate( EC:3.6.1.19 )
event
KEGG:R00720
http://purl.org/obo/owl/KEGG#KEGG_R00720
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200221
http://purl.org/obo/owl/IMR#IMR_0200221
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
EC:3.6.1.19
http://purl.org/obo/owl/EC#EC_3.6.1.19
IMR:0200074
http://purl.org/obo/owl/IMR#IMR_0200074
Deoxy-cytidine + H2O => Deoxy-uridine + NH3( EC:3.5.4.5 )
event
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0200103
http://purl.org/obo/owl/IMR#IMR_0200103
EC:3.5.4.5
http://purl.org/obo/owl/EC#EC_3.5.4.5
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:R02485
http://purl.org/obo/owl/KEGG#KEGG_R02485
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200390
http://purl.org/obo/owl/IMR#IMR_0200390
3-Ureidopropionate + H2O => beta-Alanine + CO2 + NH3( EC:3.5.1.6 )
Ureido-propanoic acid + H2O => beta-Alanine + CO2 + NH3( EC:3.5.1.6 )
event
EC:3.5.1.6
http://purl.org/obo/owl/EC#EC_3.5.1.6
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200276
http://purl.org/obo/owl/IMR#IMR_0200276
IMR:0200438
http://purl.org/obo/owl/IMR#IMR_0200438
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
KEGG:map00410
http://purl.org/obo/owl/KEGG#KEGG_map00410
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:R00905
http://purl.org/obo/owl/KEGG#KEGG_R00905
KEGG:map00770
http://purl.org/obo/owl/KEGG#KEGG_map00770
ATP + L-Fucose = ADP + L-Fucose 1-phosphate( EC:2.7.1.52 )
event
KEGG:map00051
http://purl.org/obo/owl/KEGG#KEGG_map00051
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
KEGG:R03161
http://purl.org/obo/owl/KEGG#KEGG_R03161
EC:2.7.1.52
http://purl.org/obo/owl/EC#EC_2.7.1.52
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0200303
http://purl.org/obo/owl/IMR#IMR_0200303
IMR:0200101
http://purl.org/obo/owl/IMR#IMR_0200101
5-Phospho-alpha-D-ribose 1-diphosphate + 2,3-Pyridine-dicarboxylic acid => Nicotinate D-ribonucleotide + Pyrophosphate + CO2( EC:2.4.2.19 )
D-5-Phospho-ribosyl 1-diphosphate + 2,3-Pyridine-dicarboxylic acid => Nicotinate D-ribonucleotide + Pyrophosphate + CO2( EC:2.4.2.19 )
event
KEGG:R03348
http://purl.org/obo/owl/KEGG#KEGG_R03348
KEGG:map00760
http://purl.org/obo/owl/KEGG#KEGG_map00760
IMR:0200179
http://purl.org/obo/owl/IMR#IMR_0200179
EC:2.4.2.19
http://purl.org/obo/owl/EC#EC_2.4.2.19
IMR:0200460
http://purl.org/obo/owl/IMR#IMR_0200460
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200262
http://purl.org/obo/owl/IMR#IMR_0200262
S-Adenosyl-L-methionine + Guanidino-acetic acid => S-Adenosyl-L-homocysteine + Creatine( EC:2.1.1.2 )
event
IMR:0200054
http://purl.org/obo/owl/IMR#IMR_0200054
EC:2.1.1.2
http://purl.org/obo/owl/EC#EC_2.1.1.2
IMR:0200144
http://purl.org/obo/owl/IMR#IMR_0200144
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
KEGG:R01883
http://purl.org/obo/owl/KEGG#KEGG_R01883
IMR:0200151
http://purl.org/obo/owl/IMR#IMR_0200151
IMR:0200413
http://purl.org/obo/owl/IMR#IMR_0200413
5-Hydroxy-kynurenine => 5-Hydroxy-kynurenamine + CO2( EC:4.1.1.28 )
event
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
EC:4.1.1.28
http://purl.org/obo/owl/EC#EC_4.1.1.28
KEGG:R04909
http://purl.org/obo/owl/KEGG#KEGG_R04909
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
IMR:0200500
http://purl.org/obo/owl/IMR#IMR_0200500
IMR:0200491
http://purl.org/obo/owl/IMR#IMR_0200491
NADP+ + GDP-L-fucose = NADPH + GDP-4-dehydro-6-deoxy-D-mannose + H+( EC:1.1.1.271 )
NADP+ + GDP-L-fucose = NADPH + GDP-4-dehydro-6-deoxy-D-mannose( EC:1.1.1.271 )
event
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200150
http://purl.org/obo/owl/IMR#IMR_0200150
EC:1.1.1.271
http://purl.org/obo/owl/EC#EC_1.1.1.271
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
KEGG:R05692
http://purl.org/obo/owl/KEGG#KEGG_R05692
KEGG:map00051
http://purl.org/obo/owl/KEGG#KEGG_map00051
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
IMR:0200472
http://purl.org/obo/owl/IMR#IMR_0200472
NADPH + L-Lysine + 2-Oxo-glutaric acid + H+ => NADP+ + L-Saccharopine + H2O( EC:1.5.1.8 )
NADPH + L-Lysine + 2-Oxo-glutaric acid => NADP+ + L-Saccharopine + H2O( EC:1.5.1.8 )
event
EC:1.5.1.8
http://purl.org/obo/owl/EC#EC_1.5.1.8
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
KEGG:R00716
http://purl.org/obo/owl/KEGG#KEGG_R00716
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200155
http://purl.org/obo/owl/IMR#IMR_0200155
IMR:0200140
http://purl.org/obo/owl/IMR#IMR_0200140
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00310
http://purl.org/obo/owl/KEGG#KEGG_map00310
KEGG:map00300
http://purl.org/obo/owl/KEGG#KEGG_map00300
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
ATP + dIDP = ADP + dITP( EC:2.7.4.6 )
event
KEGG:R03530
http://purl.org/obo/owl/KEGG#KEGG_R03530
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200122
http://purl.org/obo/owl/IMR#IMR_0200122
IMR:0200073
http://purl.org/obo/owl/IMR#IMR_0200073
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
EC:2.7.4.6
http://purl.org/obo/owl/EC#EC_2.7.4.6
alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate( EC:3.1.3.9 )
D-Glucose 6-phosphate + H2O => D-Glucose + Orthophosphate( EC:3.1.3.9 )
event
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
KEGG:R01788
http://purl.org/obo/owl/KEGG#KEGG_R01788
KEGG:map00500
http://purl.org/obo/owl/KEGG#KEGG_map00500
KEGG:map00052
http://purl.org/obo/owl/KEGG#KEGG_map00052
KEGG:C00668
http://purl.org/obo/owl/KEGG#KEGG_C00668
KEGG:C00267
http://purl.org/obo/owl/KEGG#KEGG_C00267
EC:3.1.3.9
http://purl.org/obo/owl/EC#EC_3.1.3.9
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
L-Cysteine-sulfinic acid => Hypotaurine + CO2( EC:4.1.1.29 )
event
KEGG:R02466
http://purl.org/obo/owl/KEGG#KEGG_R02466
EC:4.1.1.29
http://purl.org/obo/owl/EC#EC_4.1.1.29
IMR:0200305
http://purl.org/obo/owl/IMR#IMR_0200305
KEGG:map00430
http://purl.org/obo/owl/KEGG#KEGG_map00430
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200402
http://purl.org/obo/owl/IMR#IMR_0200402
L-Serine + Pyruvic acid = Hydroxy-pyruvic acid + L-Alanine( EC:2.6.1.51 )
event
IMR:0200470
http://purl.org/obo/owl/IMR#IMR_0200470
IMR:0200453
http://purl.org/obo/owl/IMR#IMR_0200453
IMR:0200331
http://purl.org/obo/owl/IMR#IMR_0200331
IMR:0200251
http://purl.org/obo/owl/IMR#IMR_0200251
EC:2.6.1.51
http://purl.org/obo/owl/EC#EC_2.6.1.51
KEGG:R00585
http://purl.org/obo/owl/KEGG#KEGG_R00585
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
Pyridoxamine + O2 + H2O => Pyridoxal + H2O2 + NH3( EC:1.4.3.5 )
event
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
EC:1.4.3.5
http://purl.org/obo/owl/EC#EC_1.4.3.5
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
KEGG:R01710
http://purl.org/obo/owl/KEGG#KEGG_R01710
IMR:0200504
http://purl.org/obo/owl/IMR#IMR_0200504
KEGG:map00750
http://purl.org/obo/owl/KEGG#KEGG_map00750
IMR:0200382
http://purl.org/obo/owl/IMR#IMR_0200382
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
D-Mannose 1-phosphate = D-Mannose 6-phosphate( EC:5.4.2.8 )
event
KEGG:R01818
http://purl.org/obo/owl/KEGG#KEGG_R01818
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
EC:5.4.2.8
http://purl.org/obo/owl/EC#EC_5.4.2.8
IMR:0200053
http://purl.org/obo/owl/IMR#IMR_0200053
IMR:0200327
http://purl.org/obo/owl/IMR#IMR_0200327
KEGG:map00051
http://purl.org/obo/owl/KEGG#KEGG_map00051
Nicotinate D-ribonucleotide + ATP = Deamido-NAD+ + Pyrophosphate( EC:2.7.7.1 )
event
KEGG:map00760
http://purl.org/obo/owl/KEGG#KEGG_map00760
KEGG:R03005
http://purl.org/obo/owl/KEGG#KEGG_R03005
IMR:0200262
http://purl.org/obo/owl/IMR#IMR_0200262
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
EC:2.7.7.1
http://purl.org/obo/owl/EC#EC_2.7.7.1
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0200082
http://purl.org/obo/owl/IMR#IMR_0200082
NAD+ + D-Glycerate 3-phosphate = NADH + 3-Phospho-hydroxy-pyruvic acid + H+( EC:1.1.1.95 )
NAD+ + D-Glycerate 3-phosphate = NADH + 3-Phospho-hydroxy-pyruvic acid( EC:1.1.1.95 )
event
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.1.1.95
http://purl.org/obo/owl/EC#EC_1.1.1.95
IMR:0200329
http://purl.org/obo/owl/IMR#IMR_0200329
IMR:0200320
http://purl.org/obo/owl/IMR#IMR_0200320
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
KEGG:R01513
http://purl.org/obo/owl/KEGG#KEGG_R01513
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
N-Acetyl-D-mannosamine + Phosphoenol-pyruvic acid + H2O => N-Acetyl-neuraminic acid + Orthophosphate( EC:2.5.1.56 )
event
KEGG:R01804
http://purl.org/obo/owl/KEGG#KEGG_R01804
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
EC:2.5.1.56
http://purl.org/obo/owl/EC#EC_2.5.1.56
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200020
http://purl.org/obo/owl/IMR#IMR_0200020
IMR:0200282
http://purl.org/obo/owl/IMR#IMR_0200282
IMR:0200223
http://purl.org/obo/owl/IMR#IMR_0200223
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
NAD+ + 5-Hydroxy-indole-acetaldehyde + H2O => NADH + 5-Hydroxy-indole-acetic acid + H+( EC:1.2.1.3 )
NAD+ + 5-Hydroxy-indole-acetaldehyde + H2O => NADH + 5-Hydroxy-indole-acetic acid( EC:1.2.1.3 )
event
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200353
http://purl.org/obo/owl/IMR#IMR_0200353
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200052
http://purl.org/obo/owl/IMR#IMR_0200052
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.2.1.3
http://purl.org/obo/owl/EC#EC_1.2.1.3
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
KEGG:R04903
http://purl.org/obo/owl/KEGG#KEGG_R04903
Adenosine + Orthophosphate = Adenine + D-Ribose 1-phosphate( EC:2.4.2.1 )
event
IMR:0200350
http://purl.org/obo/owl/IMR#IMR_0200350
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0100126
http://purl.org/obo/owl/IMR#IMR_0100126
EC:2.4.2.1
http://purl.org/obo/owl/EC#EC_2.4.2.1
KEGG:R01561
http://purl.org/obo/owl/KEGG#KEGG_R01561
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:C00620
http://purl.org/obo/owl/KEGG#KEGG_C00620
beta-D-Fructose 6-phosphate + D-Glyceraldehyde 3-phosphate = D-Erythrose 4-phosphate + D-Xylulose 5-phosphate( EC:2.2.1.1 )
D-Fructose 6-phosphate + D-Glyceraldehyde 3-phosphate = D-Erythrose 4-phosphate + D-Xylulose 5-phosphate( EC:2.2.1.1 )
event
IMR:0200012
http://purl.org/obo/owl/IMR#IMR_0200012
EC:2.2.1.1
http://purl.org/obo/owl/EC#EC_2.2.1.1
IMR:0200058
http://purl.org/obo/owl/IMR#IMR_0200058
IMR:0200169
http://purl.org/obo/owl/IMR#IMR_0200169
KEGG:C05345
http://purl.org/obo/owl/KEGG#KEGG_C05345
KEGG:map00030
http://purl.org/obo/owl/KEGG#KEGG_map00030
KEGG:R01830
http://purl.org/obo/owl/KEGG#KEGG_R01830
GDP + D-Mannose 1-phosphate => GDP-D-mannose + Orthophosphate( EC:2.7.7.22 )
event
KEGG:R00883
http://purl.org/obo/owl/KEGG#KEGG_R00883
EC:2.7.7.22
http://purl.org/obo/owl/EC#EC_2.7.7.22
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
KEGG:map00051
http://purl.org/obo/owl/KEGG#KEGG_map00051
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
IMR:0200327
http://purl.org/obo/owl/IMR#IMR_0200327
IMR:0200451
http://purl.org/obo/owl/IMR#IMR_0200451
NAD+ + 2-Propyn-1-al + H2O = NADH + Propiolic acid + H+( EC:1.2.1.3 )
NAD+ + 2-Propyn-1-al + H2O = NADH + Propiolic acid( EC:1.2.1.3 )
event
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.2.1.3
http://purl.org/obo/owl/EC#EC_1.2.1.3
KEGG:R02940
http://purl.org/obo/owl/KEGG#KEGG_R02940
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:map00640
http://purl.org/obo/owl/KEGG#KEGG_map00640
IMR:0200371
http://purl.org/obo/owl/IMR#IMR_0200371
IMR:0200503
http://purl.org/obo/owl/IMR#IMR_0200503
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
ATP + dTDP = ADP + dTTP( EC:2.7.4.6 )
event
IMR:0200084
http://purl.org/obo/owl/IMR#IMR_0200084
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
KEGG:R02093
http://purl.org/obo/owl/KEGG#KEGG_R02093
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0200338
http://purl.org/obo/owl/IMR#IMR_0200338
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:2.7.4.6
http://purl.org/obo/owl/EC#EC_2.7.4.6
dCMP + H2O => dUMP + NH3( EC:3.5.4.12 )
event
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
EC:3.5.4.12
http://purl.org/obo/owl/EC#EC_3.5.4.12
IMR:0200008
http://purl.org/obo/owl/IMR#IMR_0200008
IMR:0200005
http://purl.org/obo/owl/IMR#IMR_0200005
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:R01663
http://purl.org/obo/owl/KEGG#KEGG_R01663
cis-Aconitic acid + H2O = Isocitric acid( EC:4.2.1.3 )
event
KEGG:R01900
http://purl.org/obo/owl/KEGG#KEGG_R01900
KEGG:map00720
http://purl.org/obo/owl/KEGG#KEGG_map00720
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200271
http://purl.org/obo/owl/IMR#IMR_0200271
KEGG:map00630
http://purl.org/obo/owl/KEGG#KEGG_map00630
KEGG:map00020
http://purl.org/obo/owl/KEGG#KEGG_map00020
IMR:0200023
http://purl.org/obo/owl/IMR#IMR_0200023
EC:4.2.1.3
http://purl.org/obo/owl/EC#EC_4.2.1.3
2-Oxo-glutaric acid + 4-Amino-butanoic acid = L-Glutamic acid + Succinate semialdehyde( EC:2.6.1.19 )
event
KEGG:R01648
http://purl.org/obo/owl/KEGG#KEGG_R01648
EC:2.6.1.19
http://purl.org/obo/owl/EC#EC_2.6.1.19
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0100117
http://purl.org/obo/owl/IMR#IMR_0100117
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
IMR:0200454
http://purl.org/obo/owl/IMR#IMR_0200454
KEGG:map00650
http://purl.org/obo/owl/KEGG#KEGG_map00650
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
ATP + L-Arginine + tRNA(Arg) => AMP + L-Arginyl-tRNA(Arg) + Pyrophosphate( EC:6.1.1.19 )
event
KEGG:map00970
http://purl.org/obo/owl/KEGG#KEGG_map00970
IMR:0200428
http://purl.org/obo/owl/IMR#IMR_0200428
IMR:0200366
http://purl.org/obo/owl/IMR#IMR_0200366
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0200072
http://purl.org/obo/owl/IMR#IMR_0200072
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:6.1.1.19
http://purl.org/obo/owl/EC#EC_6.1.1.19
KEGG:R03646
http://purl.org/obo/owl/KEGG#KEGG_R03646
L-Alanine + Glyoxylic acid = Pyruvic acid + Glycine( EC:2.6.1.44 )
event
IMR:0100118
http://purl.org/obo/owl/IMR#IMR_0100118
EC:2.6.1.44
http://purl.org/obo/owl/EC#EC_2.6.1.44
IMR:0200251
http://purl.org/obo/owl/IMR#IMR_0200251
IMR:0200184
http://purl.org/obo/owl/IMR#IMR_0200184
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
IMR:0200331
http://purl.org/obo/owl/IMR#IMR_0200331
KEGG:R00369
http://purl.org/obo/owl/KEGG#KEGG_R00369
2-Oxo-glutaric acid + L-Valine = L-Glutamic acid + 3-Methyl-2-oxo-butanoic acid( EC:2.6.1.42 )
event
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
EC:2.6.1.42
http://purl.org/obo/owl/EC#EC_2.6.1.42
IMR:0200501
http://purl.org/obo/owl/IMR#IMR_0200501
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
IMR:0200088
http://purl.org/obo/owl/IMR#IMR_0200088
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
KEGG:map00966
http://purl.org/obo/owl/KEGG#KEGG_map00966
KEGG:R01214
http://purl.org/obo/owl/KEGG#KEGG_R01214
KEGG:map00290
http://purl.org/obo/owl/KEGG#KEGG_map00290
KEGG:map00770
http://purl.org/obo/owl/KEGG#KEGG_map00770
(R)-S-Lactoyl-glutathione = Glutathione + Methyl-glyoxal( EC:4.4.1.5 )
event
EC:4.4.1.5
http://purl.org/obo/owl/EC#EC_4.4.1.5
IMR:0200318
http://purl.org/obo/owl/IMR#IMR_0200318
IMR:0002043
http://purl.org/obo/owl/IMR#IMR_0002043
KEGG:map00620
http://purl.org/obo/owl/KEGG#KEGG_map00620
IMR:0200471
http://purl.org/obo/owl/IMR#IMR_0200471
KEGG:R02530
http://purl.org/obo/owl/KEGG#KEGG_R02530
L-Glutamine + H2O = L-Glutamic acid + NH3( EC:3.5.1.2 )
event
IMR:0200448
http://purl.org/obo/owl/IMR#IMR_0200448
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
EC:3.5.1.2
http://purl.org/obo/owl/EC#EC_3.5.1.2
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
KEGG:map00471
http://purl.org/obo/owl/KEGG#KEGG_map00471
KEGG:map00910
http://purl.org/obo/owl/KEGG#KEGG_map00910
KEGG:R00256
http://purl.org/obo/owl/KEGG#KEGG_R00256
NAD+ + L-4-Hydroxy-glutamate semialdehyde + H2O => NADH + L-erythro-4-Hydroxy-glutamic acid + H+( EC:1.5.1.12 )
NAD+ + L-4-Hydroxy-glutamate semialdehyde + H2O => NADH + L-erythro-4-Hydroxy-glutamic acid( EC:1.5.1.12 )
event
KEGG:R05051
http://purl.org/obo/owl/KEGG#KEGG_R05051
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
EC:1.5.1.12
http://purl.org/obo/owl/EC#EC_1.5.1.12
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200340
http://purl.org/obo/owl/IMR#IMR_0200340
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200091
http://purl.org/obo/owl/IMR#IMR_0200091
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
ATP + L-Cysteine + tRNA(Cys) => AMP + L-Cysteinyl-tRNA(Cys) + Pyrophosphate( EC:6.1.1.16 )
event
IMR:0200044
http://purl.org/obo/owl/IMR#IMR_0200044
IMR:0200014
http://purl.org/obo/owl/IMR#IMR_0200014
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:6.1.1.16
http://purl.org/obo/owl/EC#EC_6.1.1.16
KEGG:R03650
http://purl.org/obo/owl/KEGG#KEGG_R03650
IMR:0200467
http://purl.org/obo/owl/IMR#IMR_0200467
KEGG:map00970
http://purl.org/obo/owl/KEGG#KEGG_map00970
3-Hydroxyisovaleryl-CoA = 3-Methylbut-2-enoyl-CoA + H2O( EC:4.2.1.17 )
3-Hydroxy-isopentyl-CoA = 3-Methylbut-2-enoyl-CoA + H2O( EC:4.2.1.17 )
event
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
KEGG:R04137
http://purl.org/obo/owl/KEGG#KEGG_R04137
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:C05998
http://purl.org/obo/owl/KEGG#KEGG_C05998
EC:4.2.1.17
http://purl.org/obo/owl/EC#EC_4.2.1.17
IMR:0200298
http://purl.org/obo/owl/IMR#IMR_0200298
2-Oxo-glutaric acid + L-Aspartic acid = L-Glutamic acid + Oxaloacetic acid( EC:2.6.1.1 )
event
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
KEGG:map00710
http://purl.org/obo/owl/KEGG#KEGG_map00710
KEGG:R00355
http://purl.org/obo/owl/KEGG#KEGG_R00355
IMR:0200339
http://purl.org/obo/owl/IMR#IMR_0200339
IMR:0200459
http://purl.org/obo/owl/IMR#IMR_0200459
EC:2.6.1.1
http://purl.org/obo/owl/EC#EC_2.6.1.1
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
3',5'-Cyclic AMP + H2O => AMP( EC:3.1.4.17 )
event
KEGG:R00191
http://purl.org/obo/owl/KEGG#KEGG_R00191
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
EC:3.1.4.17
http://purl.org/obo/owl/EC#EC_3.1.4.17
IMR:0100024
http://purl.org/obo/owl/IMR#IMR_0100024
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
L-Proline + 2-Oxo-glutaric acid + O2 => trans-4-Hydroxy-L-proline + Succinic acid + CO2( EC:1.14.11.2 )
event
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200299
http://purl.org/obo/owl/IMR#IMR_0200299
IMR:0200119
http://purl.org/obo/owl/IMR#IMR_0200119
IMR:0200183
http://purl.org/obo/owl/IMR#IMR_0200183
KEGG:R01252
http://purl.org/obo/owl/KEGG#KEGG_R01252
EC:1.14.11.2
http://purl.org/obo/owl/EC#EC_1.14.11.2
GTP + L-Fucose 1-phosphate = GDP-L-fucose + Pyrophosphate( EC:2.7.7.30 )
event
KEGG:R01951
http://purl.org/obo/owl/KEGG#KEGG_R01951
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200150
http://purl.org/obo/owl/IMR#IMR_0200150
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
KEGG:map00051
http://purl.org/obo/owl/KEGG#KEGG_map00051
EC:2.7.7.30
http://purl.org/obo/owl/EC#EC_2.7.7.30
IMR:0200101
http://purl.org/obo/owl/IMR#IMR_0200101
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
ATP + AMP = 2 ADP( EC:2.7.4.3 )
event
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
EC:2.7.4.3
http://purl.org/obo/owl/EC#EC_2.7.4.3
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R00127
http://purl.org/obo/owl/KEGG#KEGG_R00127
NADPH + Prostaglandin D2 + H+ => NADP+ + 11-epi-Prostaglandin F2alpha( EC:1.1.1.188 )
NADPH + Prostaglandin D2 => NADP+ + 11-epi-Prostaglandin F2alpha( EC:1.1.1.188 )
event
KEGG:R02799
http://purl.org/obo/owl/KEGG#KEGG_R02799
IMR:0200457
http://purl.org/obo/owl/IMR#IMR_0200457
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
KEGG:map00590
http://purl.org/obo/owl/KEGG#KEGG_map00590
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.1.1.188
http://purl.org/obo/owl/EC#EC_1.1.1.188
IMR:0200046
http://purl.org/obo/owl/IMR#IMR_0200046
ATP + dCDP = ADP + dCTP( EC:2.7.4.6 )
event
IMR:0200078
http://purl.org/obo/owl/IMR#IMR_0200078
IMR:0200235
http://purl.org/obo/owl/IMR#IMR_0200235
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:R02326
http://purl.org/obo/owl/KEGG#KEGG_R02326
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:2.7.4.6
http://purl.org/obo/owl/EC#EC_2.7.4.6
Inosine + Orthophosphate = Hypoxanthine + D-Ribose 1-phosphate( EC:2.4.2.1 )
event
KEGG:R01863
http://purl.org/obo/owl/KEGG#KEGG_R01863
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
EC:2.4.2.1
http://purl.org/obo/owl/EC#EC_2.4.2.1
IMR:0200194
http://purl.org/obo/owl/IMR#IMR_0200194
IMR:0200173
http://purl.org/obo/owl/IMR#IMR_0200173
KEGG:C00620
http://purl.org/obo/owl/KEGG#KEGG_C00620
D-Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate = D-Erythrose 4-phosphate + beta-D-Fructose 6-phosphate( EC:2.2.1.2 )
D-Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate = D-Erythrose 4-phosphate + D-Fructose 6-phosphate( EC:2.2.1.2 )
event
KEGG:map00030
http://purl.org/obo/owl/KEGG#KEGG_map00030
KEGG:C05345
http://purl.org/obo/owl/KEGG#KEGG_C05345
KEGG:R01827
http://purl.org/obo/owl/KEGG#KEGG_R01827
IMR:0200012
http://purl.org/obo/owl/IMR#IMR_0200012
EC:2.2.1.2
http://purl.org/obo/owl/EC#EC_2.2.1.2
IMR:0200141
http://purl.org/obo/owl/IMR#IMR_0200141
IMR:0200058
http://purl.org/obo/owl/IMR#IMR_0200058
L-Tyrosine => Tyramine + CO2( EC:4.1.1.28 )
event
IMR:0100124
http://purl.org/obo/owl/IMR#IMR_0100124
EC:4.1.1.28
http://purl.org/obo/owl/EC#EC_4.1.1.28
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
KEGG:map00950
http://purl.org/obo/owl/KEGG#KEGG_map00950
IMR:0200240
http://purl.org/obo/owl/IMR#IMR_0200240
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
KEGG:R00736
http://purl.org/obo/owl/KEGG#KEGG_R00736
Cytidine + H2O => Uridine + NH3( EC:3.5.4.5 )
event
KEGG:R01878
http://purl.org/obo/owl/KEGG#KEGG_R01878
EC:3.5.4.5
http://purl.org/obo/owl/EC#EC_3.5.4.5
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200161
http://purl.org/obo/owl/IMR#IMR_0200161
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0200021
http://purl.org/obo/owl/IMR#IMR_0200021
ATP + H2O => ADP + Orthophosphate( EC:3.6.1.5 )
event
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
KEGG:R00086
http://purl.org/obo/owl/KEGG#KEGG_R00086
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
EC:3.6.1.5
http://purl.org/obo/owl/EC#EC_3.6.1.5
Nicotinamide D-ribonucleotide + Pyrophosphate = Nicotinamide + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.12 )
Nicotinamide D-ribonucleotide + Pyrophosphate = Nicotinamide + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.12 )
event
IMR:0200179
http://purl.org/obo/owl/IMR#IMR_0200179
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200025
http://purl.org/obo/owl/IMR#IMR_0200025
IMR:0200166
http://purl.org/obo/owl/IMR#IMR_0200166
EC:2.4.2.12
http://purl.org/obo/owl/EC#EC_2.4.2.12
KEGG:R01271
http://purl.org/obo/owl/KEGG#KEGG_R01271
KEGG:map00760
http://purl.org/obo/owl/KEGG#KEGG_map00760
ATP + 1-Phosphatidyl-1D-myo-inositol 5-phosphate => ADP + 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate( EC:2.7.1.149 )
event
KEGG:map04070
http://purl.org/obo/owl/KEGG#KEGG_map04070
IMR:0200149
http://purl.org/obo/owl/IMR#IMR_0200149
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
KEGG:R05803
http://purl.org/obo/owl/KEGG#KEGG_R05803
IMR:0001350
http://purl.org/obo/owl/IMR#IMR_0001350
EC:2.7.1.149
http://purl.org/obo/owl/EC#EC_2.7.1.149
Deoxy-adenosine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Adenine( EC:2.4.2.1 )
Deoxy-adenosine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Adenine( EC:2.4.2.4 )
event
EC:2.4.2.1
http://purl.org/obo/owl/EC#EC_2.4.2.1
IMR:0200048
http://purl.org/obo/owl/IMR#IMR_0200048
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200226
http://purl.org/obo/owl/IMR#IMR_0200226
IMR:0200350
http://purl.org/obo/owl/IMR#IMR_0200350
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R02557
http://purl.org/obo/owl/KEGG#KEGG_R02557
(S)-3-Hydroxy-3-methyl-glutaryl-CoA = Acetyl-CoA + Acetoacetic acid( EC:4.1.3.4 )
event
KEGG:R01360
http://purl.org/obo/owl/KEGG#KEGG_R01360
EC:4.1.3.4
http://purl.org/obo/owl/EC#EC_4.1.3.4
IMR:0200064
http://purl.org/obo/owl/IMR#IMR_0200064
IMR:0200033
http://purl.org/obo/owl/IMR#IMR_0200033
KEGG:map00072
http://purl.org/obo/owl/KEGG#KEGG_map00072
IMR:0200414
http://purl.org/obo/owl/IMR#IMR_0200414
KEGG:map00650
http://purl.org/obo/owl/KEGG#KEGG_map00650
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
S-Adenosyl-L-methionine + L-Noradrenaline => S-Adenosyl-L-homocysteine + L-Adrenaline( EC:2.1.1.28 )
event
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
IMR:0200151
http://purl.org/obo/owl/IMR#IMR_0200151
IMR:0200054
http://purl.org/obo/owl/IMR#IMR_0200054
IMR:0100115
http://purl.org/obo/owl/IMR#IMR_0100115
KEGG:R02533
http://purl.org/obo/owl/KEGG#KEGG_R02533
EC:2.1.1.28
http://purl.org/obo/owl/EC#EC_2.1.1.28
IMR:0100114
http://purl.org/obo/owl/IMR#IMR_0100114
NAD+ + CoA + (S)-Methyl-malonate semialdehyde => NADH + Propanoyl-CoA + CO2 + H+( EC:1.2.1.27 )
NAD+ + CoA + (S)-Methyl-malonate semialdehyde => NADH + Propanoyl-CoA + CO2( EC:1.2.1.27 )
event
IMR:0200297
http://purl.org/obo/owl/IMR#IMR_0200297
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
KEGG:map00640
http://purl.org/obo/owl/KEGG#KEGG_map00640
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
KEGG:R00935
http://purl.org/obo/owl/KEGG#KEGG_R00935
EC:1.2.1.27
http://purl.org/obo/owl/EC#EC_1.2.1.27
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200484
http://purl.org/obo/owl/IMR#IMR_0200484
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
NADH + L-1-Pyrroline-3-hydroxy-5-carboxylic acid + H+ = NAD+ + trans-4-Hydroxy-L-proline( EC:1.5.1.2 )
IEV:0003022: NADH + L-1-Pyrroline-3-hydroxy-5-carboxylic acid = NAD+ + trans-4-Hydroxy-L-proline( EC:1.5.1.2 )n--------------------nIEV:0003030: NAD+ + trans-4-Hydroxy-L-proline => NADH + L-1-Pyrroline-3-hydroxy-5-carboxylic acid( EC:1.5.1.12 )
event
IEV:0003030
KEGG:R03291
http://purl.org/obo/owl/KEGG#KEGG_R03291
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200225
http://purl.org/obo/owl/IMR#IMR_0200225
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200299
http://purl.org/obo/owl/IMR#IMR_0200299
EC:1.5.1.2
http://purl.org/obo/owl/EC#EC_1.5.1.2
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
N6-Acetyl-L-lysine + 2-Oxo-glutaric acid = 6-Acetamido-2-oxo-hexanoic acid + L-Glutamic acid( EC:2.6.1.65 )
N6-Acetyl-L-lysine + 2-Oxo-glutaric acid = 6-Acetamido-2-oxo-hexanoic acid + L-Glutamic acid( EC:2.6.1.39 )
event
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
IMR:0200214
http://purl.org/obo/owl/IMR#IMR_0200214
KEGG:R04029
http://purl.org/obo/owl/KEGG#KEGG_R04029
KEGG:map00310
http://purl.org/obo/owl/KEGG#KEGG_map00310
IMR:0200143
http://purl.org/obo/owl/IMR#IMR_0200143
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
EC:2.6.1.65
http://purl.org/obo/owl/EC#EC_2.6.1.65
Deoxy-guanosine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Guanine( EC:2.4.2.4 )
event
IMR:0200495
http://purl.org/obo/owl/IMR#IMR_0200495
IMR:0200319
http://purl.org/obo/owl/IMR#IMR_0200319
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
EC:2.4.2.4
http://purl.org/obo/owl/EC#EC_2.4.2.4
IMR:0200048
http://purl.org/obo/owl/IMR#IMR_0200048
KEGG:R01969
http://purl.org/obo/owl/KEGG#KEGG_R01969
Xanthosine + Orthophosphate = Xanthine + D-Ribose 1-phosphate( EC:2.4.2.1 )
event
KEGG:C00620
http://purl.org/obo/owl/KEGG#KEGG_C00620
IMR:0200439
http://purl.org/obo/owl/IMR#IMR_0200439
IMR:0200426
http://purl.org/obo/owl/IMR#IMR_0200426
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
EC:2.4.2.1
http://purl.org/obo/owl/EC#EC_2.4.2.1
KEGG:R02297
http://purl.org/obo/owl/KEGG#KEGG_R02297
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
ATP + Deoxy-uridine => ADP + dUMP( EC:2.7.1.21 )
event
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200008
http://purl.org/obo/owl/IMR#IMR_0200008
IMR:0200103
http://purl.org/obo/owl/IMR#IMR_0200103
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
EC:2.7.1.21
http://purl.org/obo/owl/EC#EC_2.7.1.21
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
KEGG:R02099
http://purl.org/obo/owl/KEGG#KEGG_R02099
CoA + GTP + Succinic acid = Succinyl-CoA + GDP + Orthophosphate( EC:6.2.1.4 )
event
KEGG:R00432
http://purl.org/obo/owl/KEGG#KEGG_R00432
EC:6.2.1.4
http://purl.org/obo/owl/EC#EC_6.2.1.4
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0200037
http://purl.org/obo/owl/IMR#IMR_0200037
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200119
http://purl.org/obo/owl/IMR#IMR_0200119
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
KEGG:map00020
http://purl.org/obo/owl/KEGG#KEGG_map00020
KEGG:map00640
http://purl.org/obo/owl/KEGG#KEGG_map00640
ATP + D-Glucosamine => ADP + D-Glucosamine 6-phosphate( EC:2.7.1.1 )
event
KEGG:R01961
http://purl.org/obo/owl/KEGG#KEGG_R01961
IMR:0200485
http://purl.org/obo/owl/IMR#IMR_0200485
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
IMR:0200228
http://purl.org/obo/owl/IMR#IMR_0200228
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:2.7.1.1
http://purl.org/obo/owl/EC#EC_2.7.1.1
ATP + Cytidine => ADP + CMP( EC:2.7.1.48 )
event
EC:2.7.1.48
http://purl.org/obo/owl/EC#EC_2.7.1.48
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200161
http://purl.org/obo/owl/IMR#IMR_0200161
IMR:0200494
http://purl.org/obo/owl/IMR#IMR_0200494
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:R00513
http://purl.org/obo/owl/KEGG#KEGG_R00513
GMP + H2O => Guanosine + Orthophosphate( EC:3.1.3.5 )
event
IMR:0200292
http://purl.org/obo/owl/IMR#IMR_0200292
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200445
http://purl.org/obo/owl/IMR#IMR_0200445
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R01227
http://purl.org/obo/owl/KEGG#KEGG_R01227
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
EC:3.1.3.5
http://purl.org/obo/owl/EC#EC_3.1.3.5
2 NADPH + (S)-3-Hydroxy-3-methyl-glutaryl-CoA + 2 H+ => 2 NADP+ + CoA + (R)-Mevalonic acid( EC:1.1.1.34 )
2 NADPH + (S)-3-Hydroxy-3-methyl-glutaryl-CoA => 2 NADP+ + CoA + (R)-Mevalonic acid( EC:1.1.1.34 )
event
EC:1.1.1.34
http://purl.org/obo/owl/EC#EC_1.1.1.34
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200033
http://purl.org/obo/owl/IMR#IMR_0200033
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
KEGG:R02082
http://purl.org/obo/owl/KEGG#KEGG_R02082
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
KEGG:map00900
http://purl.org/obo/owl/KEGG#KEGG_map00900
IMR:0200118
http://purl.org/obo/owl/IMR#IMR_0200118
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
UDP-D-glucose = UDP-D-galactose( EC:5.1.3.2 )
event
EC:5.1.3.2
http://purl.org/obo/owl/EC#EC_5.1.3.2
KEGG:map00052
http://purl.org/obo/owl/KEGG#KEGG_map00052
IMR:0200283
http://purl.org/obo/owl/IMR#IMR_0200283
IMR:0200227
http://purl.org/obo/owl/IMR#IMR_0200227
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
KEGG:R00291
http://purl.org/obo/owl/KEGG#KEGG_R00291
GDP + Reduced thioredoxin => dGDP + H2O + Oxidized thioredoxin( EC:1.17.4.1 )
event
KEGG:R02019
http://purl.org/obo/owl/KEGG#KEGG_R02019
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200365
http://purl.org/obo/owl/IMR#IMR_0200365
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
EC:1.17.4.1
http://purl.org/obo/owl/EC#EC_1.17.4.1
IMR:0200133
http://purl.org/obo/owl/IMR#IMR_0200133
IMR:0200108
http://purl.org/obo/owl/IMR#IMR_0200108
ATP + L-Asparagine + tRNA(Asn) => AMP + L-Asparaginyl-tRNA(Asn) + Pyrophosphate( EC:6.1.1.22 )
event
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200328
http://purl.org/obo/owl/IMR#IMR_0200328
KEGG:map00970
http://purl.org/obo/owl/KEGG#KEGG_map00970
KEGG:R03648
http://purl.org/obo/owl/KEGG#KEGG_R03648
EC:6.1.1.22
http://purl.org/obo/owl/EC#EC_6.1.1.22
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0200105
http://purl.org/obo/owl/IMR#IMR_0200105
IMR:0200113
http://purl.org/obo/owl/IMR#IMR_0200113
D-Glyceraldehyde 3-phosphate = Dihydroxy-acetone phosphate( EC:5.3.1.1 )
event
EC:5.3.1.1
http://purl.org/obo/owl/EC#EC_5.3.1.1
IMR:0200058
http://purl.org/obo/owl/IMR#IMR_0200058
IMR:0200100
http://purl.org/obo/owl/IMR#IMR_0200100
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
KEGG:map00051
http://purl.org/obo/owl/KEGG#KEGG_map00051
KEGG:R01015
http://purl.org/obo/owl/KEGG#KEGG_R01015
KEGG:map00710
http://purl.org/obo/owl/KEGG#KEGG_map00710
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
Lactose + H2O => alpha-D-Glucose + D-Galactose( EC:3.2.1.23 )
Lactose + H2O => D-Glucose + D-Galactose( EC:3.2.1.23 )
event
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200277
http://purl.org/obo/owl/IMR#IMR_0200277
KEGG:map00052
http://purl.org/obo/owl/KEGG#KEGG_map00052
KEGG:C00267
http://purl.org/obo/owl/KEGG#KEGG_C00267
IMR:0200123
http://purl.org/obo/owl/IMR#IMR_0200123
EC:3.2.1.23
http://purl.org/obo/owl/EC#EC_3.2.1.23
KEGG:R01678
http://purl.org/obo/owl/KEGG#KEGG_R01678
ATP + L-Glutamine + tRNA(Gln) => AMP + Glutaminyl-tRNA + Pyrophosphate( EC:6.1.1.18 )
event
KEGG:R03652
http://purl.org/obo/owl/KEGG#KEGG_R03652
EC:6.1.1.18
http://purl.org/obo/owl/EC#EC_6.1.1.18
IMR:0200117
http://purl.org/obo/owl/IMR#IMR_0200117
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
KEGG:map00970
http://purl.org/obo/owl/KEGG#KEGG_map00970
IMR:0200506
http://purl.org/obo/owl/IMR#IMR_0200506
IMR:0200448
http://purl.org/obo/owl/IMR#IMR_0200448
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
ATP + 3-Methylbut-2-enoyl-CoA + HCO3- => ADP + 3-Methyl-glutaconyl-CoA + Orthophosphate( EC:6.4.1.4 )
ATP + 3-Methylbut-2-enoyl-CoA + CO2 + H2O => ADP + 3-Methyl-glutaconyl-CoA + Orthophosphate( EC:6.4.1.4 )
event
EC:6.4.1.4
http://purl.org/obo/owl/EC#EC_6.4.1.4
KEGG:R04138
http://purl.org/obo/owl/KEGG#KEGG_R04138
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
KEGG:C00288
http://purl.org/obo/owl/KEGG#KEGG_C00288
IMR:0200298
http://purl.org/obo/owl/IMR#IMR_0200298
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200069
http://purl.org/obo/owl/IMR#IMR_0200069
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
ATP + 5'-Phospho-ribosyl-N-formyl-glycinamidine => ADP + 5'-Phospho-ribosyl-5-amino-imidazole + Orthophosphate( EC:6.3.3.1 )
event
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:6.3.3.1
http://purl.org/obo/owl/EC#EC_6.3.3.1
KEGG:R04208
http://purl.org/obo/owl/KEGG#KEGG_R04208
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200513
http://purl.org/obo/owl/IMR#IMR_0200513
IMR:0200398
http://purl.org/obo/owl/IMR#IMR_0200398
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
2-Oxo-glutaric acid + L-Leucine = L-Glutamic acid + 4-Methyl-2-oxo-pentanoic acid( EC:2.6.1.42 )
event
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
IMR:0200370
http://purl.org/obo/owl/IMR#IMR_0200370
IMR:0200492
http://purl.org/obo/owl/IMR#IMR_0200492
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
KEGG:map00290
http://purl.org/obo/owl/KEGG#KEGG_map00290
KEGG:map00966
http://purl.org/obo/owl/KEGG#KEGG_map00966
KEGG:R01090
http://purl.org/obo/owl/KEGG#KEGG_R01090
EC:2.6.1.42
http://purl.org/obo/owl/EC#EC_2.6.1.42
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
UTP + H2O => UMP + Pyrophosphate( EC:3.6.1.19 )
event
IMR:0200199
http://purl.org/obo/owl/IMR#IMR_0200199
EC:3.6.1.19
http://purl.org/obo/owl/EC#EC_3.6.1.19
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0200409
http://purl.org/obo/owl/IMR#IMR_0200409
KEGG:R00662
http://purl.org/obo/owl/KEGG#KEGG_R00662
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
ATP + (R)-5-Diphosphomevalonate => ADP + Isopentenyl diphosphate + Orthophosphate + CO2( EC:4.1.1.33 )
ATP + (R)-Mevalonic acid 5-diphosphate => ADP + Isopentenyl diphosphate + Orthophosphate + CO2( EC:4.1.1.33 )
event
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200287
http://purl.org/obo/owl/IMR#IMR_0200287
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
KEGG:R01121
http://purl.org/obo/owl/KEGG#KEGG_R01121
EC:4.1.1.33
http://purl.org/obo/owl/EC#EC_4.1.1.33
IMR:0200431
http://purl.org/obo/owl/IMR#IMR_0200431
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
KEGG:map00900
http://purl.org/obo/owl/KEGG#KEGG_map00900
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
S-Adenosyl-L-methionine + Histamine => S-Adenosyl-L-homocysteine + N-Methyl-histamine( EC:2.1.1.8 )
event
EC:2.1.1.8
http://purl.org/obo/owl/EC#EC_2.1.1.8
IMR:0100125
http://purl.org/obo/owl/IMR#IMR_0100125
KEGG:R02155
http://purl.org/obo/owl/KEGG#KEGG_R02155
IMR:0200054
http://purl.org/obo/owl/IMR#IMR_0200054
IMR:0200401
http://purl.org/obo/owl/IMR#IMR_0200401
KEGG:map00340
http://purl.org/obo/owl/KEGG#KEGG_map00340
IMR:0200151
http://purl.org/obo/owl/IMR#IMR_0200151
2-Oxo-glutaric acid + L-Phenylalanine = L-Glutamic acid + Phenyl-pyruvic acid( EC:2.6.1.5 )
event
EC:2.6.1.5
http://purl.org/obo/owl/EC#EC_2.6.1.5
IMR:0200380
http://purl.org/obo/owl/IMR#IMR_0200380
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0200274
http://purl.org/obo/owl/IMR#IMR_0200274
KEGG:map00360
http://purl.org/obo/owl/KEGG#KEGG_map00360
KEGG:R00694
http://purl.org/obo/owl/KEGG#KEGG_R00694
KEGG:map00400
http://purl.org/obo/owl/KEGG#KEGG_map00400
S-Adenosyl-L-methionine + 5-Hydroxy-indole-acetic acid => S-Adenosyl-L-homocysteine + 5-Methoxy-indole-acetic acid( EC:2.1.1.4 )
event
IMR:0200054
http://purl.org/obo/owl/IMR#IMR_0200054
IMR:0200151
http://purl.org/obo/owl/IMR#IMR_0200151
IMR:0200201
http://purl.org/obo/owl/IMR#IMR_0200201
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
EC:2.1.1.4
http://purl.org/obo/owl/EC#EC_2.1.1.4
IMR:0200052
http://purl.org/obo/owl/IMR#IMR_0200052
KEGG:R04905
http://purl.org/obo/owl/KEGG#KEGG_R04905
Phenyl-ethylamine + O2 + H2O => Phenyl-acetaldehyde + H2O2 + NH3( EC:1.4.3.21 )
Phenyl-ethylamine + O2 + H2O => Phenyl-acetaldehyde + H2O2 + NH3( EC:1.4.3.6 )
event
KEGG:map00360
http://purl.org/obo/owl/KEGG#KEGG_map00360
IMR:0200516
http://purl.org/obo/owl/IMR#IMR_0200516
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
IMR:0200418
http://purl.org/obo/owl/IMR#IMR_0200418
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
EC:1.4.3.21
http://purl.org/obo/owl/EC#EC_1.4.3.21
KEGG:R02613
http://purl.org/obo/owl/KEGG#KEGG_R02613
CoA + ATP + Butanoic acid => Butanoyl-CoA + AMP + Pyrophosphate( EC:6.2.1.2 )
event
IMR:0200308
http://purl.org/obo/owl/IMR#IMR_0200308
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
KEGG:map00650
http://purl.org/obo/owl/KEGG#KEGG_map00650
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:6.2.1.2
http://purl.org/obo/owl/EC#EC_6.2.1.2
IMR:0200195
http://purl.org/obo/owl/IMR#IMR_0200195
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
KEGG:R01176
http://purl.org/obo/owl/KEGG#KEGG_R01176
Leukotriene C4 + Amino acid => Leukotriene D4 + 5-L-Glutamyl amino acid( EC:2.3.2.2 )
Lucotriene C4 + H2O => Leucotriene D4 + L-Glutamic acid( EC:2.3.2.2 )
event
IMR:0200432
http://purl.org/obo/owl/IMR#IMR_0200432
IMR:0200458
http://purl.org/obo/owl/IMR#IMR_0200458
EC:2.3.2.2
http://purl.org/obo/owl/EC#EC_2.3.2.2
IMR:0001695
http://purl.org/obo/owl/IMR#IMR_0001695
KEGG:R03867
http://purl.org/obo/owl/KEGG#KEGG_R03867
KEGG:C03363
http://purl.org/obo/owl/KEGG#KEGG_C03363
KEGG:map00590
http://purl.org/obo/owl/KEGG#KEGG_map00590
ATP + Creatine = ADP + N-Phospho-creatine( EC:2.7.3.2 )
event
IMR:0200204
http://purl.org/obo/owl/IMR#IMR_0200204
IMR:0200144
http://purl.org/obo/owl/IMR#IMR_0200144
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
KEGG:R01881
http://purl.org/obo/owl/KEGG#KEGG_R01881
EC:2.7.3.2
http://purl.org/obo/owl/EC#EC_2.7.3.2
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
NAD+ + 4-Trimethyl-ammonio-butanal + H2O = NADH + 4-Trimethyl-ammonio-butanoic acid + H+( EC:1.2.1.47 )
NAD+ + 4-Trimethyl-ammonio-butanal + H2O = NADH + 4-Trimethyl-ammonio-butanoic acid( EC:1.2.1.47 )
event
IMR:0200070
http://purl.org/obo/owl/IMR#IMR_0200070
EC:1.2.1.47
http://purl.org/obo/owl/EC#EC_1.2.1.47
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200168
http://purl.org/obo/owl/IMR#IMR_0200168
KEGG:map00310
http://purl.org/obo/owl/KEGG#KEGG_map00310
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
KEGG:R03283
http://purl.org/obo/owl/KEGG#KEGG_R03283
NAD+ + 4-Hydroxy-phenyl-acetaldehyde + H2O = NADH + 4-Hydroxy-phenyl-acetic acid + H+( EC:1.2.1.5 )
NAD+ + 4-Hydroxy-phenyl-acetaldehyde + H2O = NADH + 4-Hydroxy-phenyl-acetic acid( EC:1.2.1.5 )
event
IMR:0200216
http://purl.org/obo/owl/IMR#IMR_0200216
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
EC:1.2.1.5
http://purl.org/obo/owl/EC#EC_1.2.1.5
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
KEGG:R02695
http://purl.org/obo/owl/KEGG#KEGG_R02695
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200040
http://purl.org/obo/owl/IMR#IMR_0200040
CDP + Reduced thioredoxin => dCDP + H2O + Oxidized thioredoxin( EC:1.17.4.1 )
event
IMR:0200078
http://purl.org/obo/owl/IMR#IMR_0200078
IMR:0200108
http://purl.org/obo/owl/IMR#IMR_0200108
IMR:0200133
http://purl.org/obo/owl/IMR#IMR_0200133
KEGG:R02024
http://purl.org/obo/owl/KEGG#KEGG_R02024
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0200468
http://purl.org/obo/owl/IMR#IMR_0200468
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
EC:1.17.4.1
http://purl.org/obo/owl/EC#EC_1.17.4.1
Dihydro-lipoylprotein + 5,10-Methylene-tetrahydro-folic acid + NH3 => S-Aminomethyl-dihydro-lipoylprotein + Tetrahydrofolate( EC:2.1.2.10 )
Dihydro-lipoylprotein + 5,10-Methylene-tetrahydro-folic acid + NH3 => S-Aminomethyl-dihydro-lipoylprotein + L-Tetrahydro-folic acid( EC:2.1.2.10 )
IEV:0002738
event
IMR:0200367
http://purl.org/obo/owl/IMR#IMR_0200367
S-aminomethyldihydrolipoyllysine + tetrahydrofolate = dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3( EC:2.1.2.10 )
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0200330
http://purl.org/obo/owl/IMR#IMR_0200330
KEGG:R04125
http://purl.org/obo/owl/KEGG#KEGG_R04125
EC:2.1.2.10
http://purl.org/obo/owl/EC#EC_2.1.2.10
IMR:0200377
http://purl.org/obo/owl/IMR#IMR_0200377
IMR:0200517
http://purl.org/obo/owl/IMR#IMR_0200517
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
KEGG:map00670
http://purl.org/obo/owl/KEGG#KEGG_map00670
CDP + H2O => CMP + Orthophosphate( EC:3.6.1.5 )
event
IMR:0200494
http://purl.org/obo/owl/IMR#IMR_0200494
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:R00514
http://purl.org/obo/owl/KEGG#KEGG_R00514
EC:3.6.1.5
http://purl.org/obo/owl/EC#EC_3.6.1.5
IMR:0200468
http://purl.org/obo/owl/IMR#IMR_0200468
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
NAD+ + 5,10-Methylene-tetrahydro-folic acid = NADH + 5,10-Methenyl-tetrahydro-folic acid( EC:1.5.1.15 )
event
IMR:0200517
http://purl.org/obo/owl/IMR#IMR_0200517
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:R01218
http://purl.org/obo/owl/KEGG#KEGG_R01218
IMR:0200159
http://purl.org/obo/owl/IMR#IMR_0200159
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
EC:1.5.1.15
http://purl.org/obo/owl/EC#EC_1.5.1.15
KEGG:map00670
http://purl.org/obo/owl/KEGG#KEGG_map00670
3-Carboxy-1-hydroxypropyl-ThPP + Enzyme N6-(lipoyl)lysine = TPP + [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine( EC:1.2.4.2 )
3-Carboxy-1-hydroxypropyl-ThPP + Lipoamide = TPP + S-Succinyl-dihydro-lipoamide( EC:1.2.4.2 )
event
EC:1.2.4.2
http://purl.org/obo/owl/EC#EC_1.2.4.2
KEGG:C16254
http://purl.org/obo/owl/KEGG#KEGG_C16254
KEGG:C15972
http://purl.org/obo/owl/KEGG#KEGG_C15972
KEGG:R03316
http://purl.org/obo/owl/KEGG#KEGG_R03316
IMR:0200378
http://purl.org/obo/owl/IMR#IMR_0200378
IMR:0002042
http://purl.org/obo/owl/IMR#IMR_0002042
KEGG:map00020
http://purl.org/obo/owl/KEGG#KEGG_map00020
Leukotriene A4 + Glutathione => Leukotriene C4( EC:4.4.1.20 )
event
KEGG:R03059
http://purl.org/obo/owl/KEGG#KEGG_R03059
IMR:0200461
http://purl.org/obo/owl/IMR#IMR_0200461
KEGG:map00590
http://purl.org/obo/owl/KEGG#KEGG_map00590
IMR:0200318
http://purl.org/obo/owl/IMR#IMR_0200318
IMR:0200458
http://purl.org/obo/owl/IMR#IMR_0200458
EC:4.4.1.20
http://purl.org/obo/owl/EC#EC_4.4.1.20
Uridine + Orthophosphate = Uracil + D-Ribose 1-phosphate( EC:2.4.2.3 )
event
KEGG:R01876
http://purl.org/obo/owl/KEGG#KEGG_R01876
IMR:0200234
http://purl.org/obo/owl/IMR#IMR_0200234
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:C00620
http://purl.org/obo/owl/KEGG#KEGG_C00620
IMR:0200021
http://purl.org/obo/owl/IMR#IMR_0200021
EC:2.4.2.3
http://purl.org/obo/owl/EC#EC_2.4.2.3
NADP+ + D-Sorbitol = NADPH + alpha-D-Glucose + H+( EC:1.1.1.21 )
NADP+ + D-Sorbitol = NADPH + alpha-D-Glucose( EC:1.1.1.21 )
event
KEGG:map00051
http://purl.org/obo/owl/KEGG#KEGG_map00051
KEGG:C00267
http://purl.org/obo/owl/KEGG#KEGG_C00267
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
EC:1.1.1.21
http://purl.org/obo/owl/EC#EC_1.1.1.21
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200462
http://purl.org/obo/owl/IMR#IMR_0200462
KEGG:R01787
http://purl.org/obo/owl/KEGG#KEGG_R01787
L-Tryptophan => Tryptamine + CO2( EC:4.1.1.28 )
event
KEGG:R00685
http://purl.org/obo/owl/KEGG#KEGG_R00685
KEGG:map00901
http://purl.org/obo/owl/KEGG#KEGG_map00901
EC:4.1.1.28
http://purl.org/obo/owl/EC#EC_4.1.1.28
IMR:0200128
http://purl.org/obo/owl/IMR#IMR_0200128
IMR:0200307
http://purl.org/obo/owl/IMR#IMR_0200307
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
Guanosine + Orthophosphate = Guanine + D-Ribose 1-phosphate( EC:2.4.2.1 )
event
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R02147
http://purl.org/obo/owl/KEGG#KEGG_R02147
IMR:0200445
http://purl.org/obo/owl/IMR#IMR_0200445
KEGG:C00620
http://purl.org/obo/owl/KEGG#KEGG_C00620
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200319
http://purl.org/obo/owl/IMR#IMR_0200319
EC:2.4.2.1
http://purl.org/obo/owl/EC#EC_2.4.2.1
NADP+ + 2 Glutathione = NADPH + Glutathione disulfide + H+( EC:1.8.1.7 )
NADP+ + 2 Glutathione = NADPH + Glutathione disulfide( EC:1.8.1.7 )
event
KEGG:map00480
http://purl.org/obo/owl/KEGG#KEGG_map00480
KEGG:R00115
http://purl.org/obo/owl/KEGG#KEGG_R00115
IMR:0200364
http://purl.org/obo/owl/IMR#IMR_0200364
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200318
http://purl.org/obo/owl/IMR#IMR_0200318
EC:1.8.1.7
http://purl.org/obo/owl/EC#EC_1.8.1.7
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
Tyramine + O2 + NADH + H+ => Dopamine + NAD+ + H2O( EC:1.14.18.1 )
Tyramine + O2 => Dopamine + H2O( EC:1.14.18.1 )
event
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:map00950
http://purl.org/obo/owl/KEGG#KEGG_map00950
EC:1.14.18.1
http://purl.org/obo/owl/EC#EC_1.14.18.1
KEGG:R02383
http://purl.org/obo/owl/KEGG#KEGG_R02383
IMR:0100113
http://purl.org/obo/owl/IMR#IMR_0100113
IMR:0100124
http://purl.org/obo/owl/IMR#IMR_0100124
ATP + (R)-Mevalonic acid 5-phosphate => ADP + (R)-5-Diphosphomevalonate( EC:2.7.4.2 )
ATP + (R)-Mevalonic acid 5-phosphate => ADP + (R)-Mevalonic acid 5-diphosphate( EC:2.7.4.2 )
event
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:2.7.4.2
http://purl.org/obo/owl/EC#EC_2.7.4.2
IMR:0200139
http://purl.org/obo/owl/IMR#IMR_0200139
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
KEGG:map00900
http://purl.org/obo/owl/KEGG#KEGG_map00900
IMR:0200431
http://purl.org/obo/owl/IMR#IMR_0200431
KEGG:R03245
http://purl.org/obo/owl/KEGG#KEGG_R03245
NADP+ + 6-Phospho-D-gluconic acid => NADPH + D-Ribulose 5-phosphate + CO2 + H+( EC:1.1.1.44 )
NADP+ + 6-Phospho-D-gluconic acid => NADPH + D-Ribulose 5-phosphate + CO2( EC:1.1.1.44 )
event
KEGG:map00480
http://purl.org/obo/owl/KEGG#KEGG_map00480
EC:1.1.1.44
http://purl.org/obo/owl/EC#EC_1.1.1.44
KEGG:R01528
http://purl.org/obo/owl/KEGG#KEGG_R01528
KEGG:map00030
http://purl.org/obo/owl/KEGG#KEGG_map00030
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200061
http://purl.org/obo/owl/IMR#IMR_0200061
IMR:0200059
http://purl.org/obo/owl/IMR#IMR_0200059
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
Succinic acid + Ubiquinone = Fumaric acid + Ubiquinol( EC:1.3.5.1 )
event
IMR:0200186
http://purl.org/obo/owl/IMR#IMR_0200186
IMR:0200119
http://purl.org/obo/owl/IMR#IMR_0200119
EC:1.3.5.1
http://purl.org/obo/owl/EC#EC_1.3.5.1
KEGG:R02164
http://purl.org/obo/owl/KEGG#KEGG_R02164
KEGG:map00020
http://purl.org/obo/owl/KEGG#KEGG_map00020
IMR:0200483
http://purl.org/obo/owl/IMR#IMR_0200483
IMR:0200466
http://purl.org/obo/owl/IMR#IMR_0200466
GDP-D-mannose => GDP-4-dehydro-6-deoxy-D-mannose + H2O( EC:4.2.1.47 )
event
KEGG:map00051
http://purl.org/obo/owl/KEGG#KEGG_map00051
IMR:0200472
http://purl.org/obo/owl/IMR#IMR_0200472
IMR:0200451
http://purl.org/obo/owl/IMR#IMR_0200451
KEGG:R00888
http://purl.org/obo/owl/KEGG#KEGG_R00888
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
EC:4.2.1.47
http://purl.org/obo/owl/EC#EC_4.2.1.47
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
Arachidonic acid + O2 => 12(S)-HPETE( EC:1.13.11.31 )
Arachidonic acid + O2 => 12-HPETE( EC:1.13.11.31 )
event
KEGG:R01596
http://purl.org/obo/owl/KEGG#KEGG_R01596
KEGG:map00590
http://purl.org/obo/owl/KEGG#KEGG_map00590
EC:1.13.11.31
http://purl.org/obo/owl/EC#EC_1.13.11.31
IMR:0200027
http://purl.org/obo/owl/IMR#IMR_0200027
IMR:0200212
http://purl.org/obo/owl/IMR#IMR_0200212
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
3',5'-Cyclic GMP + H2O => GMP( EC:3.1.4.17 )
event
IMR:0100025
http://purl.org/obo/owl/IMR#IMR_0100025
EC:3.1.4.17
http://purl.org/obo/owl/EC#EC_3.1.4.17
KEGG:R01234
http://purl.org/obo/owl/KEGG#KEGG_R01234
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200292
http://purl.org/obo/owl/IMR#IMR_0200292
Amino-acetone + O2 + H2O => Methyl-glyoxal + H2O2 + NH3( EC:1.4.3.21 )
Amino-acetone + O2 + H2O => Methyl-glyoxal + H2O2 + NH3( EC:1.4.3.6 )
event
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
KEGG:R02529
http://purl.org/obo/owl/KEGG#KEGG_R02529
IMR:0200471
http://purl.org/obo/owl/IMR#IMR_0200471
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200360
http://purl.org/obo/owl/IMR#IMR_0200360
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
EC:1.4.3.21
http://purl.org/obo/owl/EC#EC_1.4.3.21
4 Porphobilinogen + H2O => Hydroxy-methylbilane + 4 NH3( EC:2.5.1.61 )
multi-step reaction
event
EC:2.5.1.61
http://purl.org/obo/owl/EC#EC_2.5.1.61
KEGG:map00860
http://purl.org/obo/owl/KEGG#KEGG_map00860
KEGG:R00084
http://purl.org/obo/owl/KEGG#KEGG_R00084
IMR:0200002
http://purl.org/obo/owl/IMR#IMR_0200002
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200436
http://purl.org/obo/owl/IMR#IMR_0200436
NAD+ + 3-Methoxy-4-hydroxy-phenyl-acetaldehyde + H2O = NADH + Homovanillic acid + H+( EC:1.2.1.5 )
NAD+ + 3-Methoxy-4-hydroxy-phenyl-acetaldehyde + H2O = NADH + Homovanillic acid( EC:1.2.1.5 )
event
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200383
http://purl.org/obo/owl/IMR#IMR_0200383
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200269
http://purl.org/obo/owl/IMR#IMR_0200269
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
KEGG:R04888
http://purl.org/obo/owl/KEGG#KEGG_R04888
EC:1.2.1.5
http://purl.org/obo/owl/EC#EC_1.2.1.5
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
NADH + 1,3-Bisphospho-D-glyceric acid + H+ = NAD+ + D-Glyceraldehyde 3-phosphate + Orthophosphate( EC:1.2.1.12 )
NADH + 1,3-Bisphospho-D-glyceric acid = NAD+ + D-Glyceraldehyde 3-phosphate + Orthophosphate( EC:1.2.1.12 )
event
IMR:0200058
http://purl.org/obo/owl/IMR#IMR_0200058
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200362
http://purl.org/obo/owl/IMR#IMR_0200362
KEGG:R01061
http://purl.org/obo/owl/KEGG#KEGG_R01061
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.2.1.12
http://purl.org/obo/owl/EC#EC_1.2.1.12
L-Glutamine + 5-Phospho-alpha-D-ribose 1-diphosphate + H2O => L-Glutamic acid + 5-Phospho-ribosyl-1-amine + Pyrophosphate( EC:2.4.2.14 )
L-Glutamine + D-5-Phospho-ribosyl 1-diphosphate + H2O => L-Glutamic acid + 5-Phospho-ribosyl-1-amine + Pyrophosphate( EC:2.4.2.14 )
event
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
EC:2.4.2.14
http://purl.org/obo/owl/EC#EC_2.4.2.14
KEGG:R01072
http://purl.org/obo/owl/KEGG#KEGG_R01072
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200448
http://purl.org/obo/owl/IMR#IMR_0200448
IMR:0200420
http://purl.org/obo/owl/IMR#IMR_0200420
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200179
http://purl.org/obo/owl/IMR#IMR_0200179
L-Noradrenaline + H2O + O2 => 3,4-Dihydroxy-mandelaldehyde + NH3 + H2O2( EC:1.4.3.4 )
event
EC:1.4.3.4
http://purl.org/obo/owl/EC#EC_1.4.3.4
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
KEGG:R02532
http://purl.org/obo/owl/KEGG#KEGG_R02532
IMR:0100115
http://purl.org/obo/owl/IMR#IMR_0100115
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200289
http://purl.org/obo/owl/IMR#IMR_0200289
Acetyl-CoA + D-Glucosamine 6-phosphate => CoA + N-Acetyl-D-glucosamine 6-phosphate( EC:2.3.1.4 )
event
IMR:0200228
http://purl.org/obo/owl/IMR#IMR_0200228
IMR:0200259
http://purl.org/obo/owl/IMR#IMR_0200259
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
IMR:0200414
http://purl.org/obo/owl/IMR#IMR_0200414
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
KEGG:R02058
http://purl.org/obo/owl/KEGG#KEGG_R02058
EC:2.3.1.4
http://purl.org/obo/owl/EC#EC_2.3.1.4
3-Ureidoisobutyrate + H2O => 3-Aminoisobutyric acid + CO2 + NH3( EC:3.5.1.6 )
3-Ureido-2-methyl-propanoic acid + H2O => (S)-3-Amino-2-methyl-propanoic acid + CO2 + NH3( EC:3.5.1.6 )
event
IMR:0200132
http://purl.org/obo/owl/IMR#IMR_0200132
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
EC:3.5.1.6
http://purl.org/obo/owl/EC#EC_3.5.1.6
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
KEGG:R04666
http://purl.org/obo/owl/KEGG#KEGG_R04666
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:C05145
http://purl.org/obo/owl/KEGG#KEGG_C05145
Acyl-CoA + Cholesterol = CoA + Cholesterol ester( EC:2.3.1.26 )
event
KEGG:map00100
http://purl.org/obo/owl/KEGG#KEGG_map00100
IMR:0200486
http://purl.org/obo/owl/IMR#IMR_0200486
KEGG:R01461
http://purl.org/obo/owl/KEGG#KEGG_R01461
IMR:0200050
http://purl.org/obo/owl/IMR#IMR_0200050
IMR:0200065
http://purl.org/obo/owl/IMR#IMR_0200065
EC:2.3.1.26
http://purl.org/obo/owl/EC#EC_2.3.1.26
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
(S)-Dihydro-orotic acid + H2O = N-Carbamoyl-L-aspartic acid( EC:3.5.2.3 )
event
EC:3.5.2.3
http://purl.org/obo/owl/EC#EC_3.5.2.3
IMR:0200077
http://purl.org/obo/owl/IMR#IMR_0200077
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200393
http://purl.org/obo/owl/IMR#IMR_0200393
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:R01993
http://purl.org/obo/owl/KEGG#KEGG_R01993
GTP + H2O => 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydro-pteridine triphosphate + Formic acid( EC:3.5.4.16 )
four-step reaction
event
IMR:0200110
http://purl.org/obo/owl/IMR#IMR_0200110
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
EC:3.5.4.16
http://purl.org/obo/owl/EC#EC_3.5.4.16
KEGG:R00424
http://purl.org/obo/owl/KEGG#KEGG_R00424
IMR:0200406
http://purl.org/obo/owl/IMR#IMR_0200406
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
L-Dopa => Dopamine + CO2( EC:4.1.1.28 )
event
EC:4.1.1.28
http://purl.org/obo/owl/EC#EC_4.1.1.28
IMR:0100113
http://purl.org/obo/owl/IMR#IMR_0100113
KEGG:map00965
http://purl.org/obo/owl/KEGG#KEGG_map00965
KEGG:R02080
http://purl.org/obo/owl/KEGG#KEGG_R02080
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
KEGG:map00950
http://purl.org/obo/owl/KEGG#KEGG_map00950
IMR:0200290
http://purl.org/obo/owl/IMR#IMR_0200290
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
Acetyl-CoA + Serotonin => CoA + N-Acetyl-serotonin( EC:2.3.1.87 )
event
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
IMR:0200414
http://purl.org/obo/owl/IMR#IMR_0200414
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
KEGG:R02911
http://purl.org/obo/owl/KEGG#KEGG_R02911
IMR:0200180
http://purl.org/obo/owl/IMR#IMR_0200180
IMR:0100123
http://purl.org/obo/owl/IMR#IMR_0100123
EC:2.3.1.87
http://purl.org/obo/owl/EC#EC_2.3.1.87
NAD+ + H2O => Nicotinamide D-ribonucleotide + AMP( EC:3.6.1.9 )
event
KEGG:map00760
http://purl.org/obo/owl/KEGG#KEGG_map00760
EC:3.6.1.9
http://purl.org/obo/owl/EC#EC_3.6.1.9
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
KEGG:R00103
http://purl.org/obo/owl/KEGG#KEGG_R00103
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200166
http://purl.org/obo/owl/IMR#IMR_0200166
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
2-Oxo-glutaric acid + L-Tyrosine = L-Glutamic acid + 4-Hydroxy-phenyl-pyruvic acid( EC:2.6.1.5 )
event
KEGG:map00130
http://purl.org/obo/owl/KEGG#KEGG_map00130
KEGG:map00401
http://purl.org/obo/owl/KEGG#KEGG_map00401
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
KEGG:map00950
http://purl.org/obo/owl/KEGG#KEGG_map00950
KEGG:R00734
http://purl.org/obo/owl/KEGG#KEGG_R00734
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
KEGG:map00400
http://purl.org/obo/owl/KEGG#KEGG_map00400
IMR:0200240
http://purl.org/obo/owl/IMR#IMR_0200240
IMR:0200341
http://purl.org/obo/owl/IMR#IMR_0200341
EC:2.6.1.5
http://purl.org/obo/owl/EC#EC_2.6.1.5
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
UTP + D-Glucose 1-phosphate = Pyrophosphate + UDP-D-glucose( EC:2.7.7.9 )
event
KEGG:map00040
http://purl.org/obo/owl/KEGG#KEGG_map00040
KEGG:map00052
http://purl.org/obo/owl/KEGG#KEGG_map00052
KEGG:map00500
http://purl.org/obo/owl/KEGG#KEGG_map00500
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
KEGG:R00289
http://purl.org/obo/owl/KEGG#KEGG_R00289
EC:2.7.7.9
http://purl.org/obo/owl/EC#EC_2.7.7.9
IMR:0200199
http://purl.org/obo/owl/IMR#IMR_0200199
IMR:0200190
http://purl.org/obo/owl/IMR#IMR_0200190
IMR:0200283
http://purl.org/obo/owl/IMR#IMR_0200283
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
Glycine + Succinyl-CoA => CO2 + 5-Amino-4-oxo-pentanoic acid + CoA( EC:2.3.1.37 )
event
IMR:0200037
http://purl.org/obo/owl/IMR#IMR_0200037
IMR:0200264
http://purl.org/obo/owl/IMR#IMR_0200264
EC:2.3.1.37
http://purl.org/obo/owl/EC#EC_2.3.1.37
IMR:0100118
http://purl.org/obo/owl/IMR#IMR_0100118
KEGG:R00830
http://purl.org/obo/owl/KEGG#KEGG_R00830
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
CoA + 2-Methyl-3-acetoacetyl-CoA => Acetyl-CoA + Propanoyl-CoA( EC:2.3.1.16 )
event
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
KEGG:R00927
http://purl.org/obo/owl/KEGG#KEGG_R00927
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
IMR:0200288
http://purl.org/obo/owl/IMR#IMR_0200288
EC:2.3.1.16
http://purl.org/obo/owl/EC#EC_2.3.1.16
IMR:0200484
http://purl.org/obo/owl/IMR#IMR_0200484
IMR:0200414
http://purl.org/obo/owl/IMR#IMR_0200414
(R)-S-Lactoyl-glutathione + H2O => Glutathione + (R)-Lactic acid( EC:3.1.2.6 )
event
EC:3.1.2.6
http://purl.org/obo/owl/EC#EC_3.1.2.6
KEGG:map00620
http://purl.org/obo/owl/KEGG#KEGG_map00620
KEGG:R01736
http://purl.org/obo/owl/KEGG#KEGG_R01736
IMR:0200318
http://purl.org/obo/owl/IMR#IMR_0200318
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0002043
http://purl.org/obo/owl/IMR#IMR_0002043
IMR:0200313
http://purl.org/obo/owl/IMR#IMR_0200313
L-Aspartic acid => beta-Alanine + CO2( EC:4.1.1.15 )
event
KEGG:R00489
http://purl.org/obo/owl/KEGG#KEGG_R00489
KEGG:map00410
http://purl.org/obo/owl/KEGG#KEGG_map00410
KEGG:map00770
http://purl.org/obo/owl/KEGG#KEGG_map00770
IMR:0200438
http://purl.org/obo/owl/IMR#IMR_0200438
IMR:0200459
http://purl.org/obo/owl/IMR#IMR_0200459
EC:4.1.1.15
http://purl.org/obo/owl/EC#EC_4.1.1.15
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
Prostaglandin G2 + Reduced acceptor => Prostaglandin H2 + H2O + Acceptor( EC:1.14.99.1 )
event
IMR:0200300
http://purl.org/obo/owl/IMR#IMR_0200300
IMR:0200253
http://purl.org/obo/owl/IMR#IMR_0200253
IMR:0200224
http://purl.org/obo/owl/IMR#IMR_0200224
KEGG:R00073
http://purl.org/obo/owl/KEGG#KEGG_R00073
KEGG:map00590
http://purl.org/obo/owl/KEGG#KEGG_map00590
IMR:0200497
http://purl.org/obo/owl/IMR#IMR_0200497
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
EC:1.14.99.1
http://purl.org/obo/owl/EC#EC_1.14.99.1
Nicotinate D-ribonucleotide + H2O => Nicotinate D-ribonucleoside + Orthophosphate( EC:3.1.3.5 )
event
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
EC:3.1.3.5
http://purl.org/obo/owl/EC#EC_3.1.3.5
IMR:0200262
http://purl.org/obo/owl/IMR#IMR_0200262
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200104
http://purl.org/obo/owl/IMR#IMR_0200104
KEGG:map00760
http://purl.org/obo/owl/KEGG#KEGG_map00760
KEGG:R03346
http://purl.org/obo/owl/KEGG#KEGG_R03346
ATP + gamma-L-Glutamyl-L-cysteine + Glycine => ADP + Glutathione + Orthophosphate( EC:6.3.2.3 )
ATP + 5-L-Glutamyl-cysteine + Glycine => ADP + Glutathione + Orthophosphate( EC:6.3.2.3 )
event
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:6.3.2.3
http://purl.org/obo/owl/EC#EC_6.3.2.3
IMR:0100118
http://purl.org/obo/owl/IMR#IMR_0100118
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
KEGG:R00497
http://purl.org/obo/owl/KEGG#KEGG_R00497
KEGG:map00480
http://purl.org/obo/owl/KEGG#KEGG_map00480
IMR:0200423
http://purl.org/obo/owl/IMR#IMR_0200423
IMR:0200318
http://purl.org/obo/owl/IMR#IMR_0200318
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
L-Cysteine + O2 => L-Cysteine-sulfinic acid( EC:1.13.11.20 )
event
KEGG:map00270
http://purl.org/obo/owl/KEGG#KEGG_map00270
KEGG:R00893
http://purl.org/obo/owl/KEGG#KEGG_R00893
KEGG:map00430
http://purl.org/obo/owl/KEGG#KEGG_map00430
IMR:0200402
http://purl.org/obo/owl/IMR#IMR_0200402
IMR:0200467
http://purl.org/obo/owl/IMR#IMR_0200467
EC:1.13.11.20
http://purl.org/obo/owl/EC#EC_1.13.11.20
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
3-Hydroxy-anthranilic acid + O2 => 2-Amino-3-carboxy-muconate semialdehyde( EC:1.13.11.6 )
event
IMR:0200192
http://purl.org/obo/owl/IMR#IMR_0200192
EC:1.13.11.6
http://purl.org/obo/owl/EC#EC_1.13.11.6
IMR:0200400
http://purl.org/obo/owl/IMR#IMR_0200400
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
KEGG:R02665
http://purl.org/obo/owl/KEGG#KEGG_R02665
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
S-Adenosylmethioninamine + Spermidine => 5'-Methylthio-adenosine + Spermine( EC:2.5.1.22 )
S-Adenosyl-L-methioninamine + Spermidine => 5'-Methylthio-adenosine + Spermine( EC:2.5.1.22 )
event
KEGG:map00410
http://purl.org/obo/owl/KEGG#KEGG_map00410
KEGG:map00480
http://purl.org/obo/owl/KEGG#KEGG_map00480
KEGG:map00270
http://purl.org/obo/owl/KEGG#KEGG_map00270
KEGG:R02869
http://purl.org/obo/owl/KEGG#KEGG_R02869
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
IMR:0200092
http://purl.org/obo/owl/IMR#IMR_0200092
IMR:0200153
http://purl.org/obo/owl/IMR#IMR_0200153
IMR:0200175
http://purl.org/obo/owl/IMR#IMR_0200175
IMR:0200285
http://purl.org/obo/owl/IMR#IMR_0200285
EC:2.5.1.22
http://purl.org/obo/owl/EC#EC_2.5.1.22
CoA + ATP + Acetic acid => Acetyl-CoA + AMP + Pyrophosphate( EC:6.2.1.1 )
two-step reaction
event
EC:6.2.1.1
http://purl.org/obo/owl/EC#EC_6.2.1.1
KEGG:R00235
http://purl.org/obo/owl/KEGG#KEGG_R00235
KEGG:map00720
http://purl.org/obo/owl/KEGG#KEGG_map00720
IMR:0200208
http://purl.org/obo/owl/IMR#IMR_0200208
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
IMR:0200414
http://purl.org/obo/owl/IMR#IMR_0200414
NADPH + Prostaglandin E2 + H+ => NADP+ + Prostaglandin F2alpha( EC:1.1.1.189 )
NADPH + Prostaglandin E2 => NADP+ + Prostaglandin F2alpha( EC:1.1.1.189 )
event
KEGG:map00590
http://purl.org/obo/owl/KEGG#KEGG_map00590
IMR:0200146
http://purl.org/obo/owl/IMR#IMR_0200146
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200051
http://purl.org/obo/owl/IMR#IMR_0200051
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
EC:1.1.1.189
http://purl.org/obo/owl/EC#EC_1.1.1.189
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
KEGG:R02581
http://purl.org/obo/owl/KEGG#KEGG_R02581
1D-myo-Inositol 3,4-bisphosphate + H2O => 1D-myo-Inositol 3-phosphate + Orthophosphate( EC:3.1.3.66 )
event
EC:3.1.3.66
http://purl.org/obo/owl/EC#EC_3.1.3.66
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200349
http://purl.org/obo/owl/IMR#IMR_0200349
IMR:0200334
http://purl.org/obo/owl/IMR#IMR_0200334
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
KEGG:R04372
http://purl.org/obo/owl/KEGG#KEGG_R04372
KEGG:map04070
http://purl.org/obo/owl/KEGG#KEGG_map04070
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
(R)-Methyl-malonyl-CoA = Succinyl-CoA( EC:5.4.99.2 )
event
EC:5.4.99.2
http://purl.org/obo/owl/EC#EC_5.4.99.2
IMR:0200037
http://purl.org/obo/owl/IMR#IMR_0200037
IMR:0200515
http://purl.org/obo/owl/IMR#IMR_0200515
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
KEGG:map00640
http://purl.org/obo/owl/KEGG#KEGG_map00640
KEGG:R00833
http://purl.org/obo/owl/KEGG#KEGG_R00833
Uroporphyrinogen I => Coproporphyrinogen I + 4 CO2( EC:4.1.1.37 )
event
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
KEGG:map00860
http://purl.org/obo/owl/KEGG#KEGG_map00860
IMR:0200522
http://purl.org/obo/owl/IMR#IMR_0200522
KEGG:R04972
http://purl.org/obo/owl/KEGG#KEGG_R04972
EC:4.1.1.37
http://purl.org/obo/owl/EC#EC_4.1.1.37
IMR:0200131
http://purl.org/obo/owl/IMR#IMR_0200131
L-Ornithine => Putrescine + CO2( EC:4.1.1.17 )
event
EC:4.1.1.17
http://purl.org/obo/owl/EC#EC_4.1.1.17
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
IMR:0200342
http://purl.org/obo/owl/IMR#IMR_0200342
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200028
http://purl.org/obo/owl/IMR#IMR_0200028
KEGG:map00480
http://purl.org/obo/owl/KEGG#KEGG_map00480
KEGG:R00670
http://purl.org/obo/owl/KEGG#KEGG_R00670
S-Adenosyl-L-methionine + Tryptamine => S-Adenosyl-L-homocysteine + N-Methyl-tryptamine( EC:2.1.1.49 )
event
IMR:0200151
http://purl.org/obo/owl/IMR#IMR_0200151
IMR:0200310
http://purl.org/obo/owl/IMR#IMR_0200310
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
KEGG:R02174
http://purl.org/obo/owl/KEGG#KEGG_R02174
EC:2.1.1.49
http://purl.org/obo/owl/EC#EC_2.1.1.49
IMR:0200054
http://purl.org/obo/owl/IMR#IMR_0200054
IMR:0200128
http://purl.org/obo/owl/IMR#IMR_0200128
N-Acetyl-L-aspartic acid + H2O => L-Aspartic acid + Acetic acid( EC:3.5.1.15 )
event
EC:3.5.1.15
http://purl.org/obo/owl/EC#EC_3.5.1.15
IMR:0200208
http://purl.org/obo/owl/IMR#IMR_0200208
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200459
http://purl.org/obo/owl/IMR#IMR_0200459
IMR:0200478
http://purl.org/obo/owl/IMR#IMR_0200478
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
KEGG:R00488
http://purl.org/obo/owl/KEGG#KEGG_R00488
Histamine + O2 + H2O => Imidazole-4-acetaldehyde + NH3 + H2O2( EC:1.4.3.22 )
Histamine + O2 + H2O => Imidazole-4-acetaldehyde + NH3 + H2O2( EC:1.4.3.6 )
event
EC:1.4.3.22
http://purl.org/obo/owl/EC#EC_1.4.3.22
KEGG:map00340
http://purl.org/obo/owl/KEGG#KEGG_map00340
KEGG:R02150
http://purl.org/obo/owl/KEGG#KEGG_R02150
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200352
http://purl.org/obo/owl/IMR#IMR_0200352
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0100125
http://purl.org/obo/owl/IMR#IMR_0100125
N-Acetyl-alpha-D-glucosamine 1-phosphate = N-Acetyl-D-glucosamine 6-phosphate( EC:5.4.2.3 )
N-Acetyl-D-glucosamine 1-phosphate = N-Acetyl-D-glucosamine 6-phosphate( EC:5.4.2.3 )
event
IMR:0200259
http://purl.org/obo/owl/IMR#IMR_0200259
KEGG:C04501
http://purl.org/obo/owl/KEGG#KEGG_C04501
EC:5.4.2.3
http://purl.org/obo/owl/EC#EC_5.4.2.3
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
KEGG:R08193
http://purl.org/obo/owl/KEGG#KEGG_R08193
NADP+ + Hydroxy-acetone = NADPH + Methyl-glyoxal + H+( EC:1.1.1.- )
NAD+ + Hydroxy-acetone = NADH + Methyl-glyoxal( EC:1.1.1.- )
event
IMR:0200471
http://purl.org/obo/owl/IMR#IMR_0200471
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
KEGG:R02528
http://purl.org/obo/owl/KEGG#KEGG_R02528
IMR:0200136
http://purl.org/obo/owl/IMR#IMR_0200136
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.1.1.-
http://purl.org/obo/owl/EC#EC_1.1.1.-
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
1D-myo-Inositol 1,4,5-trisphosphate + H2O => 1D-myo-Inositol 1,4-bisphosphate + Orthophosphate( EC:3.1.3.56 )
event
KEGG:map04070
http://purl.org/obo/owl/KEGG#KEGG_map04070
KEGG:R03394
http://purl.org/obo/owl/KEGG#KEGG_R03394
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0100028
http://purl.org/obo/owl/IMR#IMR_0100028
IMR:0100698
http://purl.org/obo/owl/IMR#IMR_0100698
EC:3.1.3.56
http://purl.org/obo/owl/EC#EC_3.1.3.56
L-Cysteic acid => Taurine + CO2( EC:4.1.1.15 )
event
IMR:0100120
http://purl.org/obo/owl/IMR#IMR_0100120
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
EC:4.1.1.15
http://purl.org/obo/owl/EC#EC_4.1.1.15
KEGG:R01682
http://purl.org/obo/owl/KEGG#KEGG_R01682
KEGG:map00430
http://purl.org/obo/owl/KEGG#KEGG_map00430
IMR:0200417
http://purl.org/obo/owl/IMR#IMR_0200417
ATP + beta-D-Fructose 6-phosphate => ADP + beta-D-Fructose 1,6-bisphosphate( EC:2.7.1.11 )
ATP + D-Fructose 6-phosphate => ADP + D-Fructose 1,6-bisphosphate( EC:2.7.1.11 )
event
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
KEGG:C05378
http://purl.org/obo/owl/KEGG#KEGG_C05378
KEGG:C05345
http://purl.org/obo/owl/KEGG#KEGG_C05345
KEGG:map00030
http://purl.org/obo/owl/KEGG#KEGG_map00030
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
KEGG:R04779
http://purl.org/obo/owl/KEGG#KEGG_R04779
KEGG:map00051
http://purl.org/obo/owl/KEGG#KEGG_map00051
EC:2.7.1.11
http://purl.org/obo/owl/EC#EC_2.7.1.11
2 Protoporphyrinogen IX + 3 O2 => 2 Protoporphyrin IX + 6 H2O( EC:1.3.3.4 )
Protoporphyrinogen IX + 1.5 O2 => Protoporphyrin IX + 3 H2O( EC:1.3.3.4 ):multi-step reaction
event
KEGG:map00860
http://purl.org/obo/owl/KEGG#KEGG_map00860
IMR:0200523
http://purl.org/obo/owl/IMR#IMR_0200523
KEGG:R03222
http://purl.org/obo/owl/KEGG#KEGG_R03222
IMR:0200089
http://purl.org/obo/owl/IMR#IMR_0200089
EC:1.3.3.4
http://purl.org/obo/owl/EC#EC_1.3.3.4
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
ATP + L-Glutamic acid + tRNA(Glu) => AMP + L-Glutamyl-tRNA(Glu) + Pyrophosphate( EC:6.1.1.17 )
event
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:6.1.1.17
http://purl.org/obo/owl/EC#EC_6.1.1.17
IMR:0200125
http://purl.org/obo/owl/IMR#IMR_0200125
IMR:0200231
http://purl.org/obo/owl/IMR#IMR_0200231
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
KEGG:map00970
http://purl.org/obo/owl/KEGG#KEGG_map00970
KEGG:R05578
http://purl.org/obo/owl/KEGG#KEGG_R05578
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
KEGG:map00860
http://purl.org/obo/owl/KEGG#KEGG_map00860
GDP + Phosphoenol-pyruvic acid => GTP + Pyruvic acid( EC:2.7.1.40 )
event
IMR:0200331
http://purl.org/obo/owl/IMR#IMR_0200331
IMR:0200223
http://purl.org/obo/owl/IMR#IMR_0200223
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
KEGG:R00430
http://purl.org/obo/owl/KEGG#KEGG_R00430
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
EC:2.7.1.40
http://purl.org/obo/owl/EC#EC_2.7.1.40
NAD+ + Indole-3-acetaldehyde + H2O => NADH + Indole-3-acetic acid + H+( EC:1.2.1.3 )
NAD+ + Indole-3-acetaldehyde + H2O => NADH + Indole-3-acetic acid( EC:1.2.1.3 )
event
EC:1.2.1.3
http://purl.org/obo/owl/EC#EC_1.2.1.3
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200389
http://purl.org/obo/owl/IMR#IMR_0200389
IMR:0200416
http://purl.org/obo/owl/IMR#IMR_0200416
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
KEGG:R02678
http://purl.org/obo/owl/KEGG#KEGG_R02678
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
P1,P4-Bis(5'-guanosyl) tetraphosphate + H2O => GTP + GMP( EC:3.6.1.17 )
event
IMR:0200043
http://purl.org/obo/owl/IMR#IMR_0200043
IMR:0200292
http://purl.org/obo/owl/IMR#IMR_0200292
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R01232
http://purl.org/obo/owl/KEGG#KEGG_R01232
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
EC:3.6.1.17
http://purl.org/obo/owl/EC#EC_3.6.1.17
L-Phenylalanine => Phenyl-ethylamine + CO2( EC:4.1.1.28 )
event
KEGG:R00699
http://purl.org/obo/owl/KEGG#KEGG_R00699
EC:4.1.1.28
http://purl.org/obo/owl/EC#EC_4.1.1.28
IMR:0200274
http://purl.org/obo/owl/IMR#IMR_0200274
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200516
http://purl.org/obo/owl/IMR#IMR_0200516
KEGG:map00360
http://purl.org/obo/owl/KEGG#KEGG_map00360
ATP + CMP = ADP + CDP( EC:2.7.4.14 )
event
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0200494
http://purl.org/obo/owl/IMR#IMR_0200494
IMR:0200468
http://purl.org/obo/owl/IMR#IMR_0200468
EC:2.7.4.14
http://purl.org/obo/owl/EC#EC_2.7.4.14
KEGG:R00512
http://purl.org/obo/owl/KEGG#KEGG_R00512
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
ATP + D-Galactose => ADP + alpha-D-Galactose 1-phosphate( EC:2.7.1.6 )
ATP + D-Galactose => ADP + D-Galactose 1-phosphate( EC:2.7.1.6 )
event
EC:2.7.1.6
http://purl.org/obo/owl/EC#EC_2.7.1.6
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200123
http://purl.org/obo/owl/IMR#IMR_0200123
IMR:0200304
http://purl.org/obo/owl/IMR#IMR_0200304
KEGG:map00052
http://purl.org/obo/owl/KEGG#KEGG_map00052
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
KEGG:R01092
http://purl.org/obo/owl/KEGG#KEGG_R01092
CoA + ATP + Acetoacetic acid => Acetoacetyl-CoA + AMP + Pyrophosphate( EC:6.2.1.16 )
event
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:6.2.1.16
http://purl.org/obo/owl/EC#EC_6.2.1.16
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0200064
http://purl.org/obo/owl/IMR#IMR_0200064
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
KEGG:map00650
http://purl.org/obo/owl/KEGG#KEGG_map00650
IMR:0200410
http://purl.org/obo/owl/IMR#IMR_0200410
KEGG:R01357
http://purl.org/obo/owl/KEGG#KEGG_R01357
UDP + H2O => UMP + Orthophosphate( EC:3.6.1.5 )
event
EC:3.6.1.5
http://purl.org/obo/owl/EC#EC_3.6.1.5
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200206
http://purl.org/obo/owl/IMR#IMR_0200206
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200409
http://purl.org/obo/owl/IMR#IMR_0200409
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:R00155
http://purl.org/obo/owl/KEGG#KEGG_R00155
NAD+ + 3,4-Dihydroxy-mandelaldehyde + H2O = NADH + 3,4-Dihydroxy-mandelic acid + H+( EC:1.2.1.5 )
NAD+ + 3,4-Dihydroxy-mandelaldehyde + H2O = NADH + 3,4-Dihydroxy-mandelic acid( EC:1.2.1.5 )
event
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.2.1.5
http://purl.org/obo/owl/EC#EC_1.2.1.5
IMR:0200068
http://purl.org/obo/owl/IMR#IMR_0200068
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200289
http://purl.org/obo/owl/IMR#IMR_0200289
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
KEGG:R04882
http://purl.org/obo/owl/KEGG#KEGG_R04882
Galactan + H2O => 2 D-Galactose( EC:3.2.1.23 )
notice: Galactan + H2O <=> D-Galactose + Galactan( EC:3.2.1.23 )
event
IMR:0200123
http://purl.org/obo/owl/IMR#IMR_0200123
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00052
http://purl.org/obo/owl/KEGG#KEGG_map00052
KEGG:R01105
http://purl.org/obo/owl/KEGG#KEGG_R01105
IMR:0200085
http://purl.org/obo/owl/IMR#IMR_0200085
EC:3.2.1.23
http://purl.org/obo/owl/EC#EC_3.2.1.23
D-Glucose 6-phosphate => D-myo-Inositol 3-phosphate( EC:5.5.1.4 )
D-Glucose 6-phosphate => D-myo-Inositol 1-phosphate( EC:5.5.1.4 )
event
KEGG:map00521
http://purl.org/obo/owl/KEGG#KEGG_map00521
IMR:0200430
http://purl.org/obo/owl/IMR#IMR_0200430
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
IMR:0200349
http://purl.org/obo/owl/IMR#IMR_0200349
EC:5.5.1.4
http://purl.org/obo/owl/EC#EC_5.5.1.4
KEGG:R07324
http://purl.org/obo/owl/KEGG#KEGG_R07324
N-Acetyl-putrescine + H2O + O2 => N4-Acetylaminobutanal + NH3 + H2O2( EC:1.4.3.4 )
N-Acetyl-putrescine + H2O + O2 => N4-Acetyl-amino-butyraldehyde + NH3 + H2O2( EC:1.4.3.4 )
event
KEGG:R04025
http://purl.org/obo/owl/KEGG#KEGG_R04025
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200421
http://purl.org/obo/owl/IMR#IMR_0200421
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200333
http://purl.org/obo/owl/IMR#IMR_0200333
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
EC:1.4.3.4
http://purl.org/obo/owl/EC#EC_1.4.3.4
NAD+ + 2-Hydroxy-butanoic acid = NADH + 2-Oxo-butanoic acid + H+( EC:1.1.1.27 )
NAD+ + 2-Hydroxy-butanoic acid = NADH + 2-Oxo-butanoic acid( EC:1.1.1.27 )
event
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:map00640
http://purl.org/obo/owl/KEGG#KEGG_map00640
KEGG:R01000
http://purl.org/obo/owl/KEGG#KEGG_R01000
EC:1.1.1.27
http://purl.org/obo/owl/EC#EC_1.1.1.27
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200127
http://purl.org/obo/owl/IMR#IMR_0200127
IMR:0200219
http://purl.org/obo/owl/IMR#IMR_0200219
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
5-Hydroxy-N-formyl-kynurenine + H2O => 5-Hydroxy-kynurenine + Formic acid( EC:3.5.1.9 )
event
EC:3.5.1.9
http://purl.org/obo/owl/EC#EC_3.5.1.9
IMR:0200110
http://purl.org/obo/owl/IMR#IMR_0200110
IMR:0200491
http://purl.org/obo/owl/IMR#IMR_0200491
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200411
http://purl.org/obo/owl/IMR#IMR_0200411
KEGG:R04911
http://purl.org/obo/owl/KEGG#KEGG_R04911
ATP + dADP = ADP + dATP( EC:2.7.4.6 )
event
IMR:0200237
http://purl.org/obo/owl/IMR#IMR_0200237
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R01137
http://purl.org/obo/owl/KEGG#KEGG_R01137
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200129
http://purl.org/obo/owl/IMR#IMR_0200129
EC:2.7.4.6
http://purl.org/obo/owl/EC#EC_2.7.4.6
L-Cystine + H2O => Thiocysteine + Pyruvic acid + NH3( EC:4.4.1.1 )
event
EC:4.4.1.1
http://purl.org/obo/owl/EC#EC_4.4.1.1
IMR:0200331
http://purl.org/obo/owl/IMR#IMR_0200331
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200440
http://purl.org/obo/owl/IMR#IMR_0200440
IMR:0200475
http://purl.org/obo/owl/IMR#IMR_0200475
KEGG:map00270
http://purl.org/obo/owl/KEGG#KEGG_map00270
KEGG:R02408
http://purl.org/obo/owl/KEGG#KEGG_R02408
S-Adenosyl-L-methionine + Phosphatidyl-ethanolamine => S-Adenosyl-L-homocysteine + Phosphatidyl-N-methyl-ethanolamine( EC:2.1.1.17 )
event
IMR:0200317
http://purl.org/obo/owl/IMR#IMR_0200317
IMR:0200151
http://purl.org/obo/owl/IMR#IMR_0200151
IMR:0200054
http://purl.org/obo/owl/IMR#IMR_0200054
EC:2.1.1.17
http://purl.org/obo/owl/EC#EC_2.1.1.17
IMR:0200361
http://purl.org/obo/owl/IMR#IMR_0200361
KEGG:R02056
http://purl.org/obo/owl/KEGG#KEGG_R02056
KEGG:map00564
http://purl.org/obo/owl/KEGG#KEGG_map00564
Orotidine 5'-phosphate => UMP + CO2( EC:4.1.1.23 )
5'-Orotidylic acid => UMP + CO2( EC:4.1.1.23 )
event
EC:4.1.1.23
http://purl.org/obo/owl/EC#EC_4.1.1.23
KEGG:R00965
http://purl.org/obo/owl/KEGG#KEGG_R00965
IMR:0200409
http://purl.org/obo/owl/IMR#IMR_0200409
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0200087
http://purl.org/obo/owl/IMR#IMR_0200087
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
Nicotinate D-ribonucleoside + Orthophosphate = Nicotinic acid + D-Ribose 1-phosphate( EC:2.4.2.1 )
event
KEGG:R02295
http://purl.org/obo/owl/KEGG#KEGG_R02295
KEGG:map00760
http://purl.org/obo/owl/KEGG#KEGG_map00760
KEGG:C00620
http://purl.org/obo/owl/KEGG#KEGG_C00620
IMR:0200415
http://purl.org/obo/owl/IMR#IMR_0200415
IMR:0200104
http://purl.org/obo/owl/IMR#IMR_0200104
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
EC:2.4.2.1
http://purl.org/obo/owl/EC#EC_2.4.2.1
CTP + N-Glycolyl-neuraminic acid => Pyrophosphate + CMP-N-glycolyl-neuraminic acid( EC:2.7.7.43 )
event
KEGG:R04215
http://purl.org/obo/owl/KEGG#KEGG_R04215
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200202
http://purl.org/obo/owl/IMR#IMR_0200202
IMR:0200172
http://purl.org/obo/owl/IMR#IMR_0200172
IMR:0200024
http://purl.org/obo/owl/IMR#IMR_0200024
EC:2.7.7.43
http://purl.org/obo/owl/EC#EC_2.7.7.43
Tryptamine + O2 + H2O => Indole-3-acetaldehyde + H2O2 + NH3( EC:1.4.3.22 )
Tryptamine + O2 + H2O => Indole-3-acetaldehyde + H2O2 + NH3( EC:1.4.3.6 )
event
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
EC:1.4.3.22
http://purl.org/obo/owl/EC#EC_1.4.3.22
IMR:0200128
http://purl.org/obo/owl/IMR#IMR_0200128
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200416
http://purl.org/obo/owl/IMR#IMR_0200416
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
KEGG:R02173
http://purl.org/obo/owl/KEGG#KEGG_R02173
XMP + H2O => Xanthosine + Orthophosphate( EC:3.1.3.5 )
event
KEGG:R02719
http://purl.org/obo/owl/KEGG#KEGG_R02719
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200426
http://purl.org/obo/owl/IMR#IMR_0200426
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200165
http://purl.org/obo/owl/IMR#IMR_0200165
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
EC:3.1.3.5
http://purl.org/obo/owl/EC#EC_3.1.3.5
ATP + GDP = ADP + GTP( EC:2.7.4.6 )
event
KEGG:R00330
http://purl.org/obo/owl/KEGG#KEGG_R00330
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
EC:2.7.4.6
http://purl.org/obo/owl/EC#EC_2.7.4.6
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
Isopentenyl diphosphate + Geranyl diphosphate => Farnesyl diphosphate + Pyrophosphate( EC:2.5.1.10 )
event
IMR:0200097
http://purl.org/obo/owl/IMR#IMR_0200097
EC:2.5.1.10
http://purl.org/obo/owl/EC#EC_2.5.1.10
IMR:0200287
http://purl.org/obo/owl/IMR#IMR_0200287
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
KEGG:map00900
http://purl.org/obo/owl/KEGG#KEGG_map00900
IMR:0200399
http://purl.org/obo/owl/IMR#IMR_0200399
KEGG:R02003
http://purl.org/obo/owl/KEGG#KEGG_R02003
(S)-3-Hydroxyisobutyryl-CoA = 2-Methylprop-2-enoyl-CoA + H2O( EC:4.2.1.17 )
(S)-3-Hydroxy-2-methyl-propanoyl-CoA = 2-Methylprop-2-enoyl-CoA + H2O( EC:4.2.1.17 )
event
IMR:0200434
http://purl.org/obo/owl/IMR#IMR_0200434
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200164
http://purl.org/obo/owl/IMR#IMR_0200164
EC:4.2.1.17
http://purl.org/obo/owl/EC#EC_4.2.1.17
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
KEGG:R04224
http://purl.org/obo/owl/KEGG#KEGG_R04224
Tyramine + O2 + H2O => 4-Hydroxy-phenyl-acetaldehyde + H2O2 + NH3( EC:1.4.3.21 )
Tyramine + O2 + H2O => 4-Hydroxy-phenyl-acetaldehyde + H2O2 + NH3( EC:1.4.3.6 )
event
KEGG:R02382
http://purl.org/obo/owl/KEGG#KEGG_R02382
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
IMR:0100124
http://purl.org/obo/owl/IMR#IMR_0100124
EC:1.4.3.21
http://purl.org/obo/owl/EC#EC_1.4.3.21
IMR:0200040
http://purl.org/obo/owl/IMR#IMR_0200040
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
2 ATP + L-Glutamine + HCO3- + H2O = 2 ADP + L-Glutamic acid + Carbamoyl phosphate + Orthophosphate( EC:6.3.5.5 )
ATP + L-Glutamine + CO2 + 2 H2O => ADP + L-Glutamic acid + Carbamic acid + Orthophosphate( EC:6.3.5.5 ): two-step reaction.
event
IMR:0200448
http://purl.org/obo/owl/IMR#IMR_0200448
KEGG:C00288
http://purl.org/obo/owl/KEGG#KEGG_C00288
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
KEGG:R00575
http://purl.org/obo/owl/KEGG#KEGG_R00575
EC:6.3.5.5
http://purl.org/obo/owl/EC#EC_6.3.5.5
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200109
http://purl.org/obo/owl/IMR#IMR_0200109
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
4-Trimethyl-ammonio-butanoic acid + 2-Oxo-glutaric acid + O2 => Carnitine + Succinic acid + CO2( EC:1.14.11.1 )
event
EC:1.14.11.1
http://purl.org/obo/owl/EC#EC_1.14.11.1
IMR:0200119
http://purl.org/obo/owl/IMR#IMR_0200119
IMR:0200035
http://purl.org/obo/owl/IMR#IMR_0200035
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200168
http://purl.org/obo/owl/IMR#IMR_0200168
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
KEGG:R02397
http://purl.org/obo/owl/KEGG#KEGG_R02397
KEGG:map00310
http://purl.org/obo/owl/KEGG#KEGG_map00310
S-Adenosyl-L-methionine + N-Acetyl-serotonin => S-Adenosyl-L-homocysteine + Melatonin( EC:2.1.1.4 )
event
IMR:0200151
http://purl.org/obo/owl/IMR#IMR_0200151
IMR:0200180
http://purl.org/obo/owl/IMR#IMR_0200180
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
KEGG:R03130
http://purl.org/obo/owl/KEGG#KEGG_R03130
EC:2.1.1.4
http://purl.org/obo/owl/EC#EC_2.1.1.4
IMR:0100069
http://purl.org/obo/owl/IMR#IMR_0100069
IMR:0200054
http://purl.org/obo/owl/IMR#IMR_0200054
ATP + beta-D-Fructose 6-phosphate => ADP + D-Fructose 2,6-bisphosphate( EC:2.7.1.105 )
ATP + D-Fructose 6-phosphate => ADP + D-Fructose 2,6-bisphosphate( EC:2.7.1.105 )
event
EC:2.7.1.105
http://purl.org/obo/owl/EC#EC_2.7.1.105
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
KEGG:C05345
http://purl.org/obo/owl/KEGG#KEGG_C05345
IMR:0200263
http://purl.org/obo/owl/IMR#IMR_0200263
KEGG:R02732
http://purl.org/obo/owl/KEGG#KEGG_R02732
KEGG:map00051
http://purl.org/obo/owl/KEGG#KEGG_map00051
L-Histidine => Histamine + CO2( EC:4.1.1.22 )
event
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
KEGG:R01167
http://purl.org/obo/owl/KEGG#KEGG_R01167
EC:4.1.1.22
http://purl.org/obo/owl/EC#EC_4.1.1.22
KEGG:map00340
http://purl.org/obo/owl/KEGG#KEGG_map00340
IMR:0100125
http://purl.org/obo/owl/IMR#IMR_0100125
IMR:0200137
http://purl.org/obo/owl/IMR#IMR_0200137
dADP + Phosphoenol-pyruvic acid => dATP + Pyruvic acid( EC:2.7.1.40 )
event
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200331
http://purl.org/obo/owl/IMR#IMR_0200331
IMR:0200237
http://purl.org/obo/owl/IMR#IMR_0200237
IMR:0200223
http://purl.org/obo/owl/IMR#IMR_0200223
IMR:0200129
http://purl.org/obo/owl/IMR#IMR_0200129
EC:2.7.1.40
http://purl.org/obo/owl/EC#EC_2.7.1.40
KEGG:R01138
http://purl.org/obo/owl/KEGG#KEGG_R01138
Butanoyl-CoA + NAD+ = Crotonoyl-CoA + NADH + H+( EC:1.3.99.2 )
Butanoyl-CoA + Acceptor = Crotonoyl-CoA + Reduced acceptor( EC:1.3.99.2 )
event
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.3.99.2
http://purl.org/obo/owl/EC#EC_1.3.99.2
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200195
http://purl.org/obo/owl/IMR#IMR_0200195
IMR:0200121
http://purl.org/obo/owl/IMR#IMR_0200121
KEGG:R01171
http://purl.org/obo/owl/KEGG#KEGG_R01171
KEGG:map00650
http://purl.org/obo/owl/KEGG#KEGG_map00650
NAD+ + Isocitric acid = NADH + 2-Oxo-glutaric acid + CO2 + H+( EC:1.1.1.41 )
NAD+ + Isocitric acid = NADH + 2-Oxo-glutaric acid + CO2( EC:1.1.1.41 )
event
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200023
http://purl.org/obo/owl/IMR#IMR_0200023
EC:1.1.1.41
http://purl.org/obo/owl/EC#EC_1.1.1.41
KEGG:map00020
http://purl.org/obo/owl/KEGG#KEGG_map00020
KEGG:R00709
http://purl.org/obo/owl/KEGG#KEGG_R00709
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
Dopamine + H2O + O2 => 3,4-Dihydroxy-phenyl-acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
event
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200346
http://purl.org/obo/owl/IMR#IMR_0200346
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
KEGG:map00950
http://purl.org/obo/owl/KEGG#KEGG_map00950
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
KEGG:R04300
http://purl.org/obo/owl/KEGG#KEGG_R04300
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0100113
http://purl.org/obo/owl/IMR#IMR_0100113
EC:1.4.3.4
http://purl.org/obo/owl/EC#EC_1.4.3.4
5-Hydroxy-indole-acetic acid => 5-Hydroxy-indole-acetylglycine( EC:6.3.2.- )
ATP + 5-Hydroxy-indole-acetic acid + Glycine => ADP + 5-Hydroxy-indole-acetylglycine + Orthophosphate( EC:6.3.2.- )
event
IMR:0200010
http://purl.org/obo/owl/IMR#IMR_0200010
EC:6.3.2.-
http://purl.org/obo/owl/EC#EC_6.3.2.-
IMR:0200052
http://purl.org/obo/owl/IMR#IMR_0200052
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
KEGG:R04906
http://purl.org/obo/owl/KEGG#KEGG_R04906
NADPH + 5alpha-Cholest-7-en-3beta-ol + O2 + H+ => NADP+ + 7-Dehydro-cholesterol + 2 H2O( EC:1.14.21.6 )
NADPH + 5-cholest-7-en-3-ol + O2 => NADP+ + 7-Dehydro-cholesterol + H2O2( EC:1.14.21.6 )
event
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200510
http://purl.org/obo/owl/IMR#IMR_0200510
KEGG:map00100
http://purl.org/obo/owl/KEGG#KEGG_map00100
KEGG:R07215
http://purl.org/obo/owl/KEGG#KEGG_R07215
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200296
http://purl.org/obo/owl/IMR#IMR_0200296
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
EC:1.14.21.6
http://purl.org/obo/owl/EC#EC_1.14.21.6
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
UMP + H2O => Uridine + Orthophosphate( EC:3.1.3.5 )
event
KEGG:R00963
http://purl.org/obo/owl/KEGG#KEGG_R00963
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0200409
http://purl.org/obo/owl/IMR#IMR_0200409
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200021
http://purl.org/obo/owl/IMR#IMR_0200021
EC:3.1.3.5
http://purl.org/obo/owl/EC#EC_3.1.3.5
ATP + L-Threonine + tRNA(Thr) => AMP + L-Threonyl-tRNA(Thr) + Pyrophosphate( EC:6.1.1.3 )
event
EC:6.1.1.3
http://purl.org/obo/owl/EC#EC_6.1.1.3
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200444
http://purl.org/obo/owl/IMR#IMR_0200444
IMR:0200154
http://purl.org/obo/owl/IMR#IMR_0200154
KEGG:R03663
http://purl.org/obo/owl/KEGG#KEGG_R03663
IMR:0200502
http://purl.org/obo/owl/IMR#IMR_0200502
KEGG:map00970
http://purl.org/obo/owl/KEGG#KEGG_map00970
(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA = 2-Methylbut-2-enoyl-CoA + H2O( EC:4.2.1.17 )
(S)-3-Hydroxy-2-methyl-butanoyl-CoA = 2-Methylbut-2-enoyl-CoA + H2O( EC:4.2.1.17 )
event
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200207
http://purl.org/obo/owl/IMR#IMR_0200207
EC:4.2.1.17
http://purl.org/obo/owl/EC#EC_4.2.1.17
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
KEGG:R04204
http://purl.org/obo/owl/KEGG#KEGG_R04204
IMR:0200465
http://purl.org/obo/owl/IMR#IMR_0200465
NAD+ + 3,4-Dihydroxy-phenyl-acetaldehyde + H2O = NADH + 3,4-Dihydroxy-phenyl-acetic acid + H+( EC:1.2.1.5 )
NAD+ + 3,4-Dihydroxy-phenyl-acetaldehyde + H2O = NADH + 3,4-Dihydroxy-phenyl-acetic acid( EC:1.2.1.5 )
event
EC:1.2.1.5
http://purl.org/obo/owl/EC#EC_1.2.1.5
IMR:0200026
http://purl.org/obo/owl/IMR#IMR_0200026
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
KEGG:R03300
http://purl.org/obo/owl/KEGG#KEGG_R03300
IMR:0200346
http://purl.org/obo/owl/IMR#IMR_0200346
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
Acetyl phosphate + H2O = Acetic acid + Orthophosphate( EC:3.6.1.7 )
event
IMR:0200266
http://purl.org/obo/owl/IMR#IMR_0200266
IMR:0200208
http://purl.org/obo/owl/IMR#IMR_0200208
KEGG:R00317
http://purl.org/obo/owl/KEGG#KEGG_R00317
KEGG:map00620
http://purl.org/obo/owl/KEGG#KEGG_map00620
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
EC:3.6.1.7
http://purl.org/obo/owl/EC#EC_3.6.1.7
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
ATP + Deamido-NAD+ + L-Glutamine + H2O => AMP + NAD+ + L-Glutamic acid + Pyrophosphate( EC:6.3.5.1 )
event
EC:6.3.5.1
http://purl.org/obo/owl/EC#EC_6.3.5.1
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0200082
http://purl.org/obo/owl/IMR#IMR_0200082
KEGG:R00257
http://purl.org/obo/owl/KEGG#KEGG_R00257
KEGG:map00760
http://purl.org/obo/owl/KEGG#KEGG_map00760
IMR:0200448
http://purl.org/obo/owl/IMR#IMR_0200448
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
ATP + Pyridoxine => ADP + Pyridoxine 5'-phosphate( EC:2.7.1.35 )
event
KEGG:R01909
http://purl.org/obo/owl/KEGG#KEGG_R01909
EC:2.7.1.35
http://purl.org/obo/owl/EC#EC_2.7.1.35
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
KEGG:map00750
http://purl.org/obo/owl/KEGG#KEGG_map00750
IMR:0200429
http://purl.org/obo/owl/IMR#IMR_0200429
IMR:0200344
http://purl.org/obo/owl/IMR#IMR_0200344
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
AMP + H2O => Adenosine + Orthophosphate( EC:3.1.3.5 )
event
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:R00183
http://purl.org/obo/owl/KEGG#KEGG_R00183
IMR:0100126
http://purl.org/obo/owl/IMR#IMR_0100126
EC:3.1.3.5
http://purl.org/obo/owl/EC#EC_3.1.3.5
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
NADH + (S)-1-Pyrroline-5-carboxylic acid + H+ = NAD+ + L-Proline( EC:1.5.1.2 )
NADH + (S)-1-Pyrroline-5-carboxylic acid = NAD+ + L-Proline( EC:1.5.1.2 )
event
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200183
http://purl.org/obo/owl/IMR#IMR_0200183
IMR:0200236
http://purl.org/obo/owl/IMR#IMR_0200236
EC:1.5.1.2
http://purl.org/obo/owl/EC#EC_1.5.1.2
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
KEGG:R01248
http://purl.org/obo/owl/KEGG#KEGG_R01248
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
Tryptamine + H2O + O2 => Indole-3-acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
event
EC:1.4.3.4
http://purl.org/obo/owl/EC#EC_1.4.3.4
KEGG:R02173
http://purl.org/obo/owl/KEGG#KEGG_R02173
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
IMR:0200128
http://purl.org/obo/owl/IMR#IMR_0200128
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
IMR:0200416
http://purl.org/obo/owl/IMR#IMR_0200416
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
2-(alpha-Hydroxyethyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine => TPP + [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine( EC:1.2.4.1 )
2-(Hydroxyethyl)-thiamine diphosphate + Lipoamide => TPP + 6-S-Acetyl-dihydro-lipoamide( EC:1.2.4.1 )
event
IMR:0200055
http://purl.org/obo/owl/IMR#IMR_0200055
KEGG:C16255
http://purl.org/obo/owl/KEGG#KEGG_C16255
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
IMR:0200378
http://purl.org/obo/owl/IMR#IMR_0200378
KEGG:C15972
http://purl.org/obo/owl/KEGG#KEGG_C15972
KEGG:R03270
http://purl.org/obo/owl/KEGG#KEGG_R03270
KEGG:map00020
http://purl.org/obo/owl/KEGG#KEGG_map00020
EC:1.2.4.1
http://purl.org/obo/owl/EC#EC_1.2.4.1
KEGG:map00620
http://purl.org/obo/owl/KEGG#KEGG_map00620
S-Adenosyl-L-methionine + Serotonin => S-Adenosyl-L-homocysteine + N-Methyl-serotonin( EC:2.1.1.49 )
event
IMR:0100123
http://purl.org/obo/owl/IMR#IMR_0100123
KEGG:R02910
http://purl.org/obo/owl/KEGG#KEGG_R02910
EC:2.1.1.49
http://purl.org/obo/owl/EC#EC_2.1.1.49
IMR:0200054
http://purl.org/obo/owl/IMR#IMR_0200054
IMR:0200151
http://purl.org/obo/owl/IMR#IMR_0200151
IMR:0200386
http://purl.org/obo/owl/IMR#IMR_0200386
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
2-Oxo-glutaric acid + L-Isoleucine = L-Glutamic acid + (S)-3-Methyl-2-oxopentanoic acid( EC:2.6.1.42 )
2-Oxo-glutaric acid + L-Isoleucine = L-Glutamic acid + (R)-2-Oxo-3-methyl-pentanoic acid( EC:2.6.1.42 )
event
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0200272
http://purl.org/obo/owl/IMR#IMR_0200272
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
KEGG:C00671
http://purl.org/obo/owl/KEGG#KEGG_C00671
KEGG:map00966
http://purl.org/obo/owl/KEGG#KEGG_map00966
KEGG:map00290
http://purl.org/obo/owl/KEGG#KEGG_map00290
EC:2.6.1.42
http://purl.org/obo/owl/EC#EC_2.6.1.42
KEGG:R02199
http://purl.org/obo/owl/KEGG#KEGG_R02199
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
2-Oxo-glutaric acid + L-O-Phospho-serine = L-Glutamic acid + 3-Phospho-hydroxy-pyruvic acid( EC:2.6.1.52 )
event
EC:2.6.1.52
http://purl.org/obo/owl/EC#EC_2.6.1.52
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
KEGG:R04173
http://purl.org/obo/owl/KEGG#KEGG_R04173
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0200329
http://purl.org/obo/owl/IMR#IMR_0200329
IMR:0200427
http://purl.org/obo/owl/IMR#IMR_0200427
ATP + CoA + Citric acid = ADP + Acetyl-CoA + Oxaloacetic acid + Orthophosphate( EC:2.3.3.8 )
multi-step reaction
event
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200339
http://purl.org/obo/owl/IMR#IMR_0200339
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
KEGG:R00352
http://purl.org/obo/owl/KEGG#KEGG_R00352
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:2.3.3.8
http://purl.org/obo/owl/EC#EC_2.3.3.8
IMR:0200473
http://purl.org/obo/owl/IMR#IMR_0200473
IMR:0200414
http://purl.org/obo/owl/IMR#IMR_0200414
KEGG:map00720
http://purl.org/obo/owl/KEGG#KEGG_map00720
KEGG:map00020
http://purl.org/obo/owl/KEGG#KEGG_map00020
UDP-D-galactose + D-Glucose => UDP + Lactose( EC:2.4.1.22 )
event
IMR:0200042
http://purl.org/obo/owl/IMR#IMR_0200042
IMR:0200206
http://purl.org/obo/owl/IMR#IMR_0200206
KEGG:R00503
http://purl.org/obo/owl/KEGG#KEGG_R00503
KEGG:map00052
http://purl.org/obo/owl/KEGG#KEGG_map00052
EC:2.4.1.22
http://purl.org/obo/owl/EC#EC_2.4.1.22
IMR:0200277
http://purl.org/obo/owl/IMR#IMR_0200277
IMR:0200227
http://purl.org/obo/owl/IMR#IMR_0200227
NAD+ + L-2-Amino-adipate 6-semialdehyde + H2O = NADH + L-2-Amino-adipic acid + H+( EC:1.2.1.31 )
NAD+ + L-2-Amino-adipate 6-semialdehyde + H2O = NADH + L-2-Amino-adipic acid( EC:1.2.1.31 )
event
IMR:0200294
http://purl.org/obo/owl/IMR#IMR_0200294
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.2.1.31
http://purl.org/obo/owl/EC#EC_1.2.1.31
IMR:0200322
http://purl.org/obo/owl/IMR#IMR_0200322
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:R03102
http://purl.org/obo/owl/KEGG#KEGG_R03102
KEGG:map00310
http://purl.org/obo/owl/KEGG#KEGG_map00310
ATP + L-Proline + tRNA(Pro) => AMP + L-Prolyl-tRNA(Pro) + Pyrophosphate( EC:6.1.1.15 )
event
EC:6.1.1.15
http://purl.org/obo/owl/EC#EC_6.1.1.15
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0200001
http://purl.org/obo/owl/IMR#IMR_0200001
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0200183
http://purl.org/obo/owl/IMR#IMR_0200183
IMR:0200359
http://purl.org/obo/owl/IMR#IMR_0200359
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
KEGG:R03661
http://purl.org/obo/owl/KEGG#KEGG_R03661
KEGG:map00970
http://purl.org/obo/owl/KEGG#KEGG_map00970
ATP + Adenosine => ADP + AMP( EC:2.7.1.20 )
event
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0100126
http://purl.org/obo/owl/IMR#IMR_0100126
EC:2.7.1.20
http://purl.org/obo/owl/EC#EC_2.7.1.20
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R00185
http://purl.org/obo/owl/KEGG#KEGG_R00185
2 Farnesyl diphosphate + NADPH + H+ => NADP+ + Squalene + 2 Pyrophosphate( EC:2.5.1.21 )
2 Farnesyl diphosphate + NADPH => NADP+ + Squalene + 2 Pyrophosphate( EC:2.5.1.21 ):two-step reaction
event
IMR:0200481
http://purl.org/obo/owl/IMR#IMR_0200481
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200097
http://purl.org/obo/owl/IMR#IMR_0200097
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:2.5.1.21
http://purl.org/obo/owl/EC#EC_2.5.1.21
KEGG:R06223
http://purl.org/obo/owl/KEGG#KEGG_R06223
NAD+ + 3-Mercapto-lactic acid = NADH + 3-Mercapto-pyruvic acid + H+( EC:1.1.1.27 )
NAD+ + 3-Mercapto-lactic acid = NADH + 3-Mercapto-pyruvic acid( EC:1.1.1.27 )
event
KEGG:R03104
http://purl.org/obo/owl/KEGG#KEGG_R03104
KEGG:map00270
http://purl.org/obo/owl/KEGG#KEGG_map00270
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200498
http://purl.org/obo/owl/IMR#IMR_0200498
IMR:0200007
http://purl.org/obo/owl/IMR#IMR_0200007
EC:1.1.1.27
http://purl.org/obo/owl/EC#EC_1.1.1.27
UDP-N-acetyl-D-glucosamine + H2O => UDP + N-acetyl-D-mannosamine( EC:5.1.3.14 )
event
KEGG:R00414
http://purl.org/obo/owl/KEGG#KEGG_R00414
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200282
http://purl.org/obo/owl/IMR#IMR_0200282
IMR:0200247
http://purl.org/obo/owl/IMR#IMR_0200247
IMR:0200206
http://purl.org/obo/owl/IMR#IMR_0200206
EC:5.1.3.14
http://purl.org/obo/owl/EC#EC_5.1.3.14
NADPH + Cholesterol + O2 + H+ = NADP+ + 7alpha-Hydroxycholesterol + H2O( EC:1.14.13.17 )
NADPH + Cholesterol + O2 = NADP+ + 7-Hydroxy-cholesterol + H2O( EC:1.14.13.17 )
event
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200404
http://purl.org/obo/owl/IMR#IMR_0200404
KEGG:map00120
http://purl.org/obo/owl/KEGG#KEGG_map00120
IMR:0200486
http://purl.org/obo/owl/IMR#IMR_0200486
KEGG:R01463
http://purl.org/obo/owl/KEGG#KEGG_R01463
EC:1.14.13.17
http://purl.org/obo/owl/EC#EC_1.14.13.17
Putrescine + O2 + H2O => 4-Amino-butyraldehyde + H2O2 + NH3( EC:1.4.3.22 )
Putrescine + O2 + H2O => 4-Amino-butyraldehyde + H2O2 + NH3( EC:1.4.3.6 )
event
KEGG:R01151
http://purl.org/obo/owl/KEGG#KEGG_R01151
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
IMR:0200028
http://purl.org/obo/owl/IMR#IMR_0200028
EC:1.4.3.22
http://purl.org/obo/owl/EC#EC_1.4.3.22
IMR:0200142
http://purl.org/obo/owl/IMR#IMR_0200142
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
ATP + L-Glutamine + L-Aspartic acid + H2O => AMP + L-Glutamic acid + L-Asparagine + Pyrophosphate( EC:6.3.5.4 )
event
IMR:0200448
http://purl.org/obo/owl/IMR#IMR_0200448
IMR:0200459
http://purl.org/obo/owl/IMR#IMR_0200459
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
IMR:0200113
http://purl.org/obo/owl/IMR#IMR_0200113
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
KEGG:R00578
http://purl.org/obo/owl/KEGG#KEGG_R00578
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00910
http://purl.org/obo/owl/KEGG#KEGG_map00910
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
EC:6.3.5.4
http://purl.org/obo/owl/EC#EC_6.3.5.4
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
NADPH + GMP + H+ => NADP+ + IMP + NH3( EC:1.7.1.7 )
NADPH + GMP => NADP+ + IMP + NH3( EC:1.7.1.7 )
event
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R01134
http://purl.org/obo/owl/KEGG#KEGG_R01134
IMR:0200221
http://purl.org/obo/owl/IMR#IMR_0200221
IMR:0200292
http://purl.org/obo/owl/IMR#IMR_0200292
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
EC:1.7.1.7
http://purl.org/obo/owl/EC#EC_1.7.1.7
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
Acetyl-CoA + Putrescine => CoA + N-Acetyl-putrescine( EC:2.3.1.57 )
event
IMR:0200028
http://purl.org/obo/owl/IMR#IMR_0200028
IMR:0200333
http://purl.org/obo/owl/IMR#IMR_0200333
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
IMR:0200414
http://purl.org/obo/owl/IMR#IMR_0200414
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
KEGG:R01154
http://purl.org/obo/owl/KEGG#KEGG_R01154
EC:2.3.1.57
http://purl.org/obo/owl/EC#EC_2.3.1.57
5-Formimino-tetrahydro-folic acid + H+ = 5,10-Methenyl-tetrahydro-folic acid + NH3( EC:4.3.1.4 )
5-Formimino-tetrahydro-folic acid = 5,10-Methenyl-tetrahydro-folic acid + NH3( EC:4.3.1.4 )
event
IMR:0200159
http://purl.org/obo/owl/IMR#IMR_0200159
IMR:0200443
http://purl.org/obo/owl/IMR#IMR_0200443
KEGG:map00670
http://purl.org/obo/owl/KEGG#KEGG_map00670
KEGG:R02302
http://purl.org/obo/owl/KEGG#KEGG_R02302
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:4.3.1.4
http://purl.org/obo/owl/EC#EC_4.3.1.4
ATP + GMP = ADP + GDP( EC:2.7.4.8 )
event
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R00332
http://purl.org/obo/owl/KEGG#KEGG_R00332
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200292
http://purl.org/obo/owl/IMR#IMR_0200292
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
EC:2.7.4.8
http://purl.org/obo/owl/EC#EC_2.7.4.8
1D-myo-Inositol 3-phosphate + H2O => myo-Inositol + Orthophosphate( EC:3.1.3.25 )
event
IMR:0200177
http://purl.org/obo/owl/IMR#IMR_0200177
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
EC:3.1.3.25
http://purl.org/obo/owl/EC#EC_3.1.3.25
KEGG:R01187
http://purl.org/obo/owl/KEGG#KEGG_R01187
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
KEGG:map04070
http://purl.org/obo/owl/KEGG#KEGG_map04070
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00521
http://purl.org/obo/owl/KEGG#KEGG_map00521
IMR:0200349
http://purl.org/obo/owl/IMR#IMR_0200349
TPP + Pyruvic acid => 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2( EC:1.2.4.1 )
TPP + Pyruvic acid => 2-(Hydroxyethyl)-thiamine diphosphate + CO2( EC:1.2.4.1 ):subsequently IEV:0003160
event
KEGG:R00014
http://purl.org/obo/owl/KEGG#KEGG_R00014
EC:1.2.4.1
http://purl.org/obo/owl/EC#EC_1.2.4.1
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200055
http://purl.org/obo/owl/IMR#IMR_0200055
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
IMR:0200378
http://purl.org/obo/owl/IMR#IMR_0200378
IMR:0200331
http://purl.org/obo/owl/IMR#IMR_0200331
KEGG:map00650
http://purl.org/obo/owl/KEGG#KEGG_map00650
KEGG:map00620
http://purl.org/obo/owl/KEGG#KEGG_map00620
KEGG:map00290
http://purl.org/obo/owl/KEGG#KEGG_map00290
KEGG:map00020
http://purl.org/obo/owl/KEGG#KEGG_map00020
D-Glucono-1,5-lactone 6-phosphate + H2O => 6-Phospho-D-gluconic acid( EC:3.1.1.31 )
D-6-Phospho-glucono 1,5-lactone + H2O => 6-Phospho-D-gluconic acid( EC:3.1.1.31 )
event
KEGG:R02035
http://purl.org/obo/owl/KEGG#KEGG_R02035
KEGG:map00030
http://purl.org/obo/owl/KEGG#KEGG_map00030
IMR:0200059
http://purl.org/obo/owl/IMR#IMR_0200059
IMR:0200508
http://purl.org/obo/owl/IMR#IMR_0200508
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
EC:3.1.1.31
http://purl.org/obo/owl/EC#EC_3.1.1.31
ATP + 5'-Phospho-ribosyl-N-formyl-glycinamide + L-Glutamine + H2O => ADP + 5'-Phospho-ribosyl-N-formyl-glycinamidine + L-Glutamic acid + Orthophosphate( EC:6.3.5.3 )
event
IMR:0200022
http://purl.org/obo/owl/IMR#IMR_0200022
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200448
http://purl.org/obo/owl/IMR#IMR_0200448
IMR:0200398
http://purl.org/obo/owl/IMR#IMR_0200398
KEGG:R04463
http://purl.org/obo/owl/KEGG#KEGG_R04463
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:6.3.5.3
http://purl.org/obo/owl/EC#EC_6.3.5.3
5-Hydroxy-L-Tryptophan + O2 => 5-Hydroxy-N-formyl-kynurenine( EC:1.13.11.52 )
5-Hydroxy-L-Tryptophan + O2 => 5-Hydroxy-N-formyl-kynurenine( EC:1.13.11.42 )
event
EC:1.13.11.52
http://purl.org/obo/owl/EC#EC_1.13.11.52
IMR:0200112
http://purl.org/obo/owl/IMR#IMR_0200112
KEGG:R02702
http://purl.org/obo/owl/KEGG#KEGG_R02702
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
IMR:0200411
http://purl.org/obo/owl/IMR#IMR_0200411
2 5-Amino-4-oxo-pentanoic acid => Porphobilinogen + 2 H2O( EC:4.2.1.24 )
event
KEGG:R00036
http://purl.org/obo/owl/KEGG#KEGG_R00036
EC:4.2.1.24
http://purl.org/obo/owl/EC#EC_4.2.1.24
IMR:0200436
http://purl.org/obo/owl/IMR#IMR_0200436
KEGG:map00860
http://purl.org/obo/owl/KEGG#KEGG_map00860
IMR:0200264
http://purl.org/obo/owl/IMR#IMR_0200264
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMP + H2O = 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide( EC:3.5.4.10 )
IMP + H2O = 5'-Phospho-ribosyl-4-carboxamido-5-formamido-imidazole( EC:3.5.4.10 )
event
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R01127
http://purl.org/obo/owl/KEGG#KEGG_R01127
IMR:0200452
http://purl.org/obo/owl/IMR#IMR_0200452
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200221
http://purl.org/obo/owl/IMR#IMR_0200221
EC:3.5.4.10
http://purl.org/obo/owl/EC#EC_3.5.4.10
dUTP + H2O => dUMP + Pyrophosphate( EC:3.6.1.19 )
event
EC:3.6.1.19
http://purl.org/obo/owl/EC#EC_3.6.1.19
IMR:0200008
http://purl.org/obo/owl/IMR#IMR_0200008
IMR:0200056
http://purl.org/obo/owl/IMR#IMR_0200056
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:R02100
http://purl.org/obo/owl/KEGG#KEGG_R02100
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
ATP + L-Glutamic acid + L-Cysteine => ADP + gamma-L-Glutamyl-L-cysteine + Orthophosphate( EC:6.3.2.2 )
ATP + L-Glutamic acid + L-Cysteine => ADP + 5-L-Glutamyl-cysteine + Orthophosphate( EC:6.3.2.2 )
event
KEGG:R00894
http://purl.org/obo/owl/KEGG#KEGG_R00894
IMR:0200467
http://purl.org/obo/owl/IMR#IMR_0200467
KEGG:map00480
http://purl.org/obo/owl/KEGG#KEGG_map00480
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200423
http://purl.org/obo/owl/IMR#IMR_0200423
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
EC:6.3.2.2
http://purl.org/obo/owl/EC#EC_6.3.2.2
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
ATP + dUDP = ADP + dUTP( EC:2.7.4.6 )
event
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:2.7.4.6
http://purl.org/obo/owl/EC#EC_2.7.4.6
KEGG:R02331
http://purl.org/obo/owl/KEGG#KEGG_R02331
IMR:0200098
http://purl.org/obo/owl/IMR#IMR_0200098
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0200056
http://purl.org/obo/owl/IMR#IMR_0200056
N6,N6,N6-Trimethyl-L-lysine + 2-Oxo-glutaric acid + O2 => 3-Hydroxy-N6,N6,N6-trimethyl-L-lysine + Succinic acid + CO2( EC:1.14.11.8 )
event
IMR:0200326
http://purl.org/obo/owl/IMR#IMR_0200326
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
EC:1.14.11.8
http://purl.org/obo/owl/EC#EC_1.14.11.8
IMR:0200119
http://purl.org/obo/owl/IMR#IMR_0200119
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
IMR:0200493
http://purl.org/obo/owl/IMR#IMR_0200493
KEGG:map00310
http://purl.org/obo/owl/KEGG#KEGG_map00310
KEGG:R03451
http://purl.org/obo/owl/KEGG#KEGG_R03451
ATP + Tetrahydrofolate + L-Glutamic acid => ADP + Tetrahydrofolyl-[Glu] + Orthophosphate( EC:6.3.2.17 )
ATP + L-Tetrahydro-folic acid + L-Glutamic acid => ADP + Tetrahydrofolyl-[Glu] + Orthophosphate( EC:6.3.2.17 )
event
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:6.3.2.17
http://purl.org/obo/owl/EC#EC_6.3.2.17
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200157
http://purl.org/obo/owl/IMR#IMR_0200157
IMR:0200330
http://purl.org/obo/owl/IMR#IMR_0200330
KEGG:map00790
http://purl.org/obo/owl/KEGG#KEGG_map00790
KEGG:R00942
http://purl.org/obo/owl/KEGG#KEGG_R00942
1D-myo-Inositol 1,3,4,5-tetrakisphosphate + H2O => 1D-myo-Inositol 1,3,4-trisphosphate + Orthophosphate( EC:3.1.3.56 )
event
KEGG:R03430
http://purl.org/obo/owl/KEGG#KEGG_R03430
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
KEGG:map04070
http://purl.org/obo/owl/KEGG#KEGG_map04070
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200124
http://purl.org/obo/owl/IMR#IMR_0200124
EC:3.1.3.56
http://purl.org/obo/owl/EC#EC_3.1.3.56
IMR:0100029
http://purl.org/obo/owl/IMR#IMR_0100029
UTP + H2O => UDP + Orthophosphate( EC:3.6.1.5 )
event
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0200199
http://purl.org/obo/owl/IMR#IMR_0200199
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200206
http://purl.org/obo/owl/IMR#IMR_0200206
EC:3.6.1.5
http://purl.org/obo/owl/EC#EC_3.6.1.5
KEGG:R00159
http://purl.org/obo/owl/KEGG#KEGG_R00159
ATP + D-Fructose => ADP + D-Fructose 1-phosphate( EC:2.7.1.3 )
event
EC:2.7.1.3
http://purl.org/obo/owl/EC#EC_2.7.1.3
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0200474
http://purl.org/obo/owl/IMR#IMR_0200474
IMR:0200120
http://purl.org/obo/owl/IMR#IMR_0200120
KEGG:R00866
http://purl.org/obo/owl/KEGG#KEGG_R00866
KEGG:map00051
http://purl.org/obo/owl/KEGG#KEGG_map00051
Pyridoxine 5'-phosphate + O2 => Pyridoxal 5'-phosphate + H2O2( EC:1.4.3.5 )
event
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
IMR:0200429
http://purl.org/obo/owl/IMR#IMR_0200429
IMR:0200229
http://purl.org/obo/owl/IMR#IMR_0200229
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
EC:1.4.3.5
http://purl.org/obo/owl/EC#EC_1.4.3.5
KEGG:R00278
http://purl.org/obo/owl/KEGG#KEGG_R00278
KEGG:map00750
http://purl.org/obo/owl/KEGG#KEGG_map00750
NADPH + L-Kynurenine + O2 + H+ => NADP+ + 3-Hydroxy-L-kynurenine + H2O( EC:1.14.13.9 )
NADPH + L-Kynurenine + O2 => NADP+ + 3-Hydroxy-L-kynurenine + H2O( EC:1.14.13.9 )
event
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200301
http://purl.org/obo/owl/IMR#IMR_0200301
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200066
http://purl.org/obo/owl/IMR#IMR_0200066
EC:1.14.13.9
http://purl.org/obo/owl/EC#EC_1.14.13.9
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
KEGG:R01960
http://purl.org/obo/owl/KEGG#KEGG_R01960
L-Tyrosine + Tetrahydrobiopterin + O2 => L-Dopa + 6,7-Dihydro-biopterin + H2O( EC:1.14.16.2 )
event
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:R01815
http://purl.org/obo/owl/KEGG#KEGG_R01815
EC:1.14.16.2
http://purl.org/obo/owl/EC#EC_1.14.16.2
IMR:0200045
http://purl.org/obo/owl/IMR#IMR_0200045
IMR:0200209
http://purl.org/obo/owl/IMR#IMR_0200209
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200240
http://purl.org/obo/owl/IMR#IMR_0200240
IMR:0200290
http://purl.org/obo/owl/IMR#IMR_0200290
ATP + 5-Phospho-ribosyl-1-amine + Glycine => ADP + 5'-Phospho-ribosyl-glycinamide + Orthophosphate( EC:6.3.4.13 )
event
EC:6.3.4.13
http://purl.org/obo/owl/EC#EC_6.3.4.13
KEGG:R04144
http://purl.org/obo/owl/KEGG#KEGG_R04144
IMR:0200420
http://purl.org/obo/owl/IMR#IMR_0200420
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200252
http://purl.org/obo/owl/IMR#IMR_0200252
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0100118
http://purl.org/obo/owl/IMR#IMR_0100118
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
NAD+ + (S)-1-Pyrroline-5-carboxylic acid + 2 H2O => NADH + L-Glutamic acid + H+( EC:1.5.1.12 )
NAD+ + (S)-1-Pyrroline-5-carboxylic acid + 2 H2O => NADH + L-Glutamic acid( EC:1.5.1.12 ):two-step reaction
event
KEGG:R00707
http://purl.org/obo/owl/KEGG#KEGG_R00707
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200236
http://purl.org/obo/owl/IMR#IMR_0200236
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.5.1.12
http://purl.org/obo/owl/EC#EC_1.5.1.12
dTMP + H2O => Thymidine + Orthophosphate( EC:3.1.3.5 )
event
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200187
http://purl.org/obo/owl/IMR#IMR_0200187
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0200384
http://purl.org/obo/owl/IMR#IMR_0200384
KEGG:R01569
http://purl.org/obo/owl/KEGG#KEGG_R01569
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
EC:3.1.3.5
http://purl.org/obo/owl/EC#EC_3.1.3.5
N-Formyl-L-aspartic acid + H2O => L-Aspartic acid + Formic acid( EC:3.5.1.15 )
event
EC:3.5.1.15
http://purl.org/obo/owl/EC#EC_3.5.1.15
KEGG:map00340
http://purl.org/obo/owl/KEGG#KEGG_map00340
IMR:0200459
http://purl.org/obo/owl/IMR#IMR_0200459
KEGG:R00526
http://purl.org/obo/owl/KEGG#KEGG_R00526
KEGG:map00630
http://purl.org/obo/owl/KEGG#KEGG_map00630
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200110
http://purl.org/obo/owl/IMR#IMR_0200110
IMR:0200049
http://purl.org/obo/owl/IMR#IMR_0200049
ATP + 1-Phosphatidyl-1D-myo-inositol => ADP + 1-Phosphatidyl-1D-myo-inositol 3-phosphate( EC:2.7.1.137 )
event
IMR:0200469
http://purl.org/obo/owl/IMR#IMR_0200469
IMR:0200387
http://purl.org/obo/owl/IMR#IMR_0200387
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
KEGG:R03362
http://purl.org/obo/owl/KEGG#KEGG_R03362
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
KEGG:map04070
http://purl.org/obo/owl/KEGG#KEGG_map04070
EC:2.7.1.137
http://purl.org/obo/owl/EC#EC_2.7.1.137
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
ATP + Pyridoxal => ADP + Pyridoxal 5'-phosphate( EC:2.7.1.35 )
event
IMR:0200229
http://purl.org/obo/owl/IMR#IMR_0200229
IMR:0200504
http://purl.org/obo/owl/IMR#IMR_0200504
KEGG:map00750
http://purl.org/obo/owl/KEGG#KEGG_map00750
EC:2.7.1.35
http://purl.org/obo/owl/EC#EC_2.7.1.35
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
KEGG:R00174
http://purl.org/obo/owl/KEGG#KEGG_R00174
NAD+ + N-Succinyl-L-glutamate 5-semialdehyde + H2O => NADH + N-Succinyl-L-glutamic acid + H+( EC:1.2.1.71 )
NAD+ + N2-Succinyl-L-glutamate 5-semialdehyde + H2O => NADH + N2-Succinyl-L-glutamic acid( EC:1.5.1.12 )
event
IMR:0200369
http://purl.org/obo/owl/IMR#IMR_0200369
EC:1.2.1.71
http://purl.org/obo/owl/EC#EC_1.2.1.71
KEGG:R05049
http://purl.org/obo/owl/KEGG#KEGG_R05049
IMR:0200222
http://purl.org/obo/owl/IMR#IMR_0200222
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
GTP => 3',5'-Cyclic GMP + Pyrophosphate( EC:4.6.1.1 )
event
EC:4.6.1.1
http://purl.org/obo/owl/EC#EC_4.6.1.1
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0100025
http://purl.org/obo/owl/IMR#IMR_0100025
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
KEGG:R00434
http://purl.org/obo/owl/KEGG#KEGG_R00434
Sarcosine + O2 + H2O => Glycine + Formaldehyde + H2O2( EC:1.5.3.1 )
event
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
EC:1.5.3.1
http://purl.org/obo/owl/EC#EC_1.5.3.1
IMR:0100118
http://purl.org/obo/owl/IMR#IMR_0100118
IMR:0200017
http://purl.org/obo/owl/IMR#IMR_0200017
IMR:0200189
http://purl.org/obo/owl/IMR#IMR_0200189
KEGG:R00610
http://purl.org/obo/owl/KEGG#KEGG_R00610
L-O-Phospho-serine + H2O => L-Serine + Orthophosphate( EC:3.1.3.3 )
event
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
EC:3.1.3.3
http://purl.org/obo/owl/EC#EC_3.1.3.3
IMR:0200427
http://purl.org/obo/owl/IMR#IMR_0200427
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
IMR:0200453
http://purl.org/obo/owl/IMR#IMR_0200453
KEGG:R00582
http://purl.org/obo/owl/KEGG#KEGG_R00582
NADP+ + 5-Methyl-tetrahydro-folic acid => NADPH + 5,10-Methylene-tetrahydro-folic acid + H+( EC:1.5.1.20 )
NADP+ + 5-Methyl-tetrahydro-folic acid => NADPH + 5,10-Methylene-tetrahydro-folic acid( EC:1.5.1.20 )
event
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200517
http://purl.org/obo/owl/IMR#IMR_0200517
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200408
http://purl.org/obo/owl/IMR#IMR_0200408
KEGG:R01224
http://purl.org/obo/owl/KEGG#KEGG_R01224
KEGG:map00670
http://purl.org/obo/owl/KEGG#KEGG_map00670
KEGG:map00680
http://purl.org/obo/owl/KEGG#KEGG_map00680
EC:1.5.1.20
http://purl.org/obo/owl/EC#EC_1.5.1.20
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
L-Ornithine + Carbamoyl phosphate => L-Citrulline + Orthophosphate( EC:2.1.3.3 )
event
KEGG:R01398
http://purl.org/obo/owl/KEGG#KEGG_R01398
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200109
http://purl.org/obo/owl/IMR#IMR_0200109
IMR:0200342
http://purl.org/obo/owl/IMR#IMR_0200342
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
IMR:0200019
http://purl.org/obo/owl/IMR#IMR_0200019
EC:2.1.3.3
http://purl.org/obo/owl/EC#EC_2.1.3.3
ATP + Adenosine-5'-phospho-sulfate => ADP + 3'-Phospho-adenosine-5'-phospho-sulfate( EC:2.7.1.25 )
event
IMR:0200032
http://purl.org/obo/owl/IMR#IMR_0200032
KEGG:R00509
http://purl.org/obo/owl/KEGG#KEGG_R00509
KEGG:map00920
http://purl.org/obo/owl/KEGG#KEGG_map00920
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200079
http://purl.org/obo/owl/IMR#IMR_0200079
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
EC:2.7.1.25
http://purl.org/obo/owl/EC#EC_2.7.1.25
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
Leukotriene A4 + H2O => Leukotriene B4( EC:3.3.2.6 )
event
EC:3.3.2.6
http://purl.org/obo/owl/EC#EC_3.3.2.6
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:R03057
http://purl.org/obo/owl/KEGG#KEGG_R03057
KEGG:map00590
http://purl.org/obo/owl/KEGG#KEGG_map00590
IMR:0200376
http://purl.org/obo/owl/IMR#IMR_0200376
IMR:0200461
http://purl.org/obo/owl/IMR#IMR_0200461
NAD+ + IMP + H2O => NADH + XMP + H+( EC:1.1.1.205 )
NAD+ + IMP + H2O => NADH + XMP( EC:1.1.1.205 )
event
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200221
http://purl.org/obo/owl/IMR#IMR_0200221
KEGG:R01130
http://purl.org/obo/owl/KEGG#KEGG_R01130
IMR:0200165
http://purl.org/obo/owl/IMR#IMR_0200165
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.1.1.205
http://purl.org/obo/owl/EC#EC_1.1.1.205
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
ATP + N-Acetyl-D-mannosamine => ADP + N-Acetyl-D-mannosamine 6-phosphate( EC:2.7.1.60 )
event
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
KEGG:R02705
http://purl.org/obo/owl/KEGG#KEGG_R02705
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200282
http://purl.org/obo/owl/IMR#IMR_0200282
IMR:0200518
http://purl.org/obo/owl/IMR#IMR_0200518
EC:2.7.1.60
http://purl.org/obo/owl/EC#EC_2.7.1.60
3 NADPH + 2 L-Arginine + 4 O2 + 3 H+ = 3 NADP+ + 2 L-Citrulline + 2 Nitric oxide + 4 H2O( EC:1.14.13.39 )
NADPH + L-Arginine + O2 = NADP+ + L-Citrulline + NO( EC:1.14.13.39 ):multi-step reaction
event
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200428
http://purl.org/obo/owl/IMR#IMR_0200428
EC:1.14.13.39
http://purl.org/obo/owl/EC#EC_1.14.13.39
IMR:0100128
http://purl.org/obo/owl/IMR#IMR_0100128
IMR:0200019
http://purl.org/obo/owl/IMR#IMR_0200019
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
KEGG:R00557
http://purl.org/obo/owl/KEGG#KEGG_R00557
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
3-Methyl-butanoyl-CoA + FAD => 3-Methylbut-2-enoyl-CoA + FADH2( EC:1.3.99.10 )
3-Methyl-butanoyl-CoA + Acceptor => 3-Methylbut-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.10 )
event
KEGG:C00016
http://purl.org/obo/owl/KEGG#KEGG_C00016
KEGG:C01352
http://purl.org/obo/owl/KEGG#KEGG_C01352
IMR:0200158
http://purl.org/obo/owl/IMR#IMR_0200158
IMR:0200298
http://purl.org/obo/owl/IMR#IMR_0200298
EC:1.3.99.10
http://purl.org/obo/owl/EC#EC_1.3.99.10
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
KEGG:R04095
http://purl.org/obo/owl/KEGG#KEGG_R04095
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate + H2O => D-myo-Inositol 1,4,5-trisphosphate + 1,2-Diacyl-sn-glycerol( EC:3.1.4.11 )
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate + H2O => D-myo-Inositol 1,4,5-trisphosphate + D-1,2-Diacyl-glycerol( EC:3.1.4.11 )
event
EC:3.1.4.11
http://purl.org/obo/owl/EC#EC_3.1.4.11
IMR:0001350
http://purl.org/obo/owl/IMR#IMR_0001350
IMR:0100028
http://purl.org/obo/owl/IMR#IMR_0100028
IMR:0200076
http://purl.org/obo/owl/IMR#IMR_0200076
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:mao04070
http://purl.org/obo/owl/KEGG#KEGG_mao04070
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
KEGG:R03435
http://purl.org/obo/owl/KEGG#KEGG_R03435
CoA + ATP + Propanoic acid => Propanoyl-CoA + AMP + Pyrophosphate( EC:6.2.1.1 )
two-step reaction:R01354, R00926
event
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0200081
http://purl.org/obo/owl/IMR#IMR_0200081
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:6.2.1.1
http://purl.org/obo/owl/EC#EC_6.2.1.1
KEGG:R00925
http://purl.org/obo/owl/KEGG#KEGG_R00925
IMR:0200484
http://purl.org/obo/owl/IMR#IMR_0200484
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
Protoporphyrin IX + Fe2+ = Protoheme + 2 H+( EC:4.99.1.1 )
Protoporphyrin IX + Iron = Protoheme + 2 H+( EC:4.99.1.1 )
event
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200089
http://purl.org/obo/owl/IMR#IMR_0200089
IMR:0200348
http://purl.org/obo/owl/IMR#IMR_0200348
KEGG:C14818
http://purl.org/obo/owl/KEGG#KEGG_C14818
KEGG:map00860
http://purl.org/obo/owl/KEGG#KEGG_map00860
KEGG:R00310
http://purl.org/obo/owl/KEGG#KEGG_R00310
EC:4.99.1.1
http://purl.org/obo/owl/EC#EC_4.99.1.1
ATP + H2O => ADP + Orthophosphate( EC:3.6.1.3 )
event
EC:3.6.1.3
http://purl.org/obo/owl/EC#EC_3.6.1.3
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
KEGG:R00086
http://purl.org/obo/owl/KEGG#KEGG_R00086
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
NAD+ + H2O => Nicotinamide + ADP-ribose( EC:3.2.2.5 )
NAD+ + H2O => Nicotinamide + ADP-5-ribose( EC:3.2.2.5 )
event
EC:3.2.2.5
http://purl.org/obo/owl/EC#EC_3.2.2.5
IMR:0200025
http://purl.org/obo/owl/IMR#IMR_0200025
IMR:0200134
http://purl.org/obo/owl/IMR#IMR_0200134
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:R00102
http://purl.org/obo/owl/KEGG#KEGG_R00102
KEGG:map00760
http://purl.org/obo/owl/KEGG#KEGG_map00760
(S)-2,3-Epoxy-squalene = Lanosterol( EC:5.4.99.7 )
event
KEGG:map00100
http://purl.org/obo/owl/KEGG#KEGG_map00100
KEGG:R03199
http://purl.org/obo/owl/KEGG#KEGG_R03199
EC:5.4.99.7
http://purl.org/obo/owl/EC#EC_5.4.99.7
IMR:0200096
http://purl.org/obo/owl/IMR#IMR_0200096
IMR:0200509
http://purl.org/obo/owl/IMR#IMR_0200509
NADPH + Presqualene diphosphate + H+ => NADP+ + Squalene + Pyrophosphate( EC:2.5.1.21 )
NADPH + Presqualene diphosphate => NADP+ + Squalene + Pyrophosphate( EC:2.5.1.21 )
event
KEGG:R02872
http://purl.org/obo/owl/KEGG#KEGG_R02872
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200481
http://purl.org/obo/owl/IMR#IMR_0200481
KEGG:map00100
http://purl.org/obo/owl/KEGG#KEGG_map00100
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200273
http://purl.org/obo/owl/IMR#IMR_0200273
EC:2.5.1.21
http://purl.org/obo/owl/EC#EC_2.5.1.21
N,N-Dimethyl-glycine + H2O + Acceptor => Sarcosine + Formaldehyde + Reduced acceptor( EC:1.5.99.2 )
event
EC:1.5.99.2
http://purl.org/obo/owl/EC#EC_1.5.99.2
KEGG:R01565
http://purl.org/obo/owl/KEGG#KEGG_R01565
IMR:0200047
http://purl.org/obo/owl/IMR#IMR_0200047
IMR:0200189
http://purl.org/obo/owl/IMR#IMR_0200189
IMR:0200017
http://purl.org/obo/owl/IMR#IMR_0200017
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
IMR:0200224
http://purl.org/obo/owl/IMR#IMR_0200224
IMR:0200300
http://purl.org/obo/owl/IMR#IMR_0200300
AMP + H2O => IMP + NH3( EC:3.5.4.6 )
event
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
EC:3.5.4.6
http://purl.org/obo/owl/EC#EC_3.5.4.6
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R00181
http://purl.org/obo/owl/KEGG#KEGG_R00181
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0200221
http://purl.org/obo/owl/IMR#IMR_0200221
2 ATP + CO2 + NH3 + H2O => 2 ADP + Carbamoyl phosphate + Orthophosphate( EC:6.3.4.16 )
event
KEGG:R00149
http://purl.org/obo/owl/KEGG#KEGG_R00149
KEGG:map00910
http://purl.org/obo/owl/KEGG#KEGG_map00910
EC:6.3.4.16
http://purl.org/obo/owl/EC#EC_6.3.4.16
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0200109
http://purl.org/obo/owl/IMR#IMR_0200109
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
N-Methyl-histamine + H2O + O2 => Methylimidazole acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
N-Methyl-histamine + H2O + O2 => 3-Methyl-imidazole acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
event
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
EC:1.4.3.4
http://purl.org/obo/owl/EC#EC_1.4.3.4
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
IMR:0200401
http://purl.org/obo/owl/IMR#IMR_0200401
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200325
http://purl.org/obo/owl/IMR#IMR_0200325
KEGG:R04674
http://purl.org/obo/owl/KEGG#KEGG_R04674
KEGG:map00340
http://purl.org/obo/owl/KEGG#KEGG_map00340
ATP + 1-Phosphatidyl-1D-myo-inositol 4-phosphate => ADP + 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate( EC:2.7.1.68 )
event
EC:2.7.1.68
http://purl.org/obo/owl/EC#EC_2.7.1.68
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001350
http://purl.org/obo/owl/IMR#IMR_0001350
IMR:0200496
http://purl.org/obo/owl/IMR#IMR_0200496
KEGG:R03469
http://purl.org/obo/owl/KEGG#KEGG_R03469
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
KEGG:map04070
http://purl.org/obo/owl/KEGG#KEGG_map04070
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
Arachidonic acid + 2 O2 => Prostaglandin G2( EC:1.14.99.1 )
Arachidonic acid + 2 O2 + Reduced acceptor => Prostaglandin G2 + Acceptor( EC:1.14.99.1 ):subsequently IEV:0003091
event
KEGG:map00590
http://purl.org/obo/owl/KEGG#KEGG_map00590
KEGG:R01590
http://purl.org/obo/owl/KEGG#KEGG_R01590
IMR:0200212
http://purl.org/obo/owl/IMR#IMR_0200212
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200497
http://purl.org/obo/owl/IMR#IMR_0200497
EC:1.14.99.1
http://purl.org/obo/owl/EC#EC_1.14.99.1
Prostaglandin H2 => Prostaglandin D2( EC:5.3.99.2 )
event
IMR:0200253
http://purl.org/obo/owl/IMR#IMR_0200253
EC:5.3.99.2
http://purl.org/obo/owl/EC#EC_5.3.99.2
KEGG:map00590
http://purl.org/obo/owl/KEGG#KEGG_map00590
IMR:0200457
http://purl.org/obo/owl/IMR#IMR_0200457
KEGG:R02266
http://purl.org/obo/owl/KEGG#KEGG_R02266
L-Cysteine + H2O => Pyruvic acid + Hydrogen sulfide + NH3( EC:4.4.1.1 )
event
KEGG:R00782
http://purl.org/obo/owl/KEGG#KEGG_R00782
IMR:0200467
http://purl.org/obo/owl/IMR#IMR_0200467
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00270
http://purl.org/obo/owl/KEGG#KEGG_map00270
IMR:0200514
http://purl.org/obo/owl/IMR#IMR_0200514
EC:4.4.1.1
http://purl.org/obo/owl/EC#EC_4.4.1.1
IMR:0200331
http://purl.org/obo/owl/IMR#IMR_0200331
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
dGDP + Phosphoenol-pyruvic acid => dGTP + Pyruvic acid( EC:2.7.1.40 )
event
EC:2.7.1.40
http://purl.org/obo/owl/EC#EC_2.7.1.40
IMR:0200223
http://purl.org/obo/owl/IMR#IMR_0200223
IMR:0200286
http://purl.org/obo/owl/IMR#IMR_0200286
IMR:0200331
http://purl.org/obo/owl/IMR#IMR_0200331
IMR:0200365
http://purl.org/obo/owl/IMR#IMR_0200365
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R01858
http://purl.org/obo/owl/KEGG#KEGG_R01858
NADPH + Prostaglandin E2 + H+ => NADP+ + Prostaglandin F2alpha( EC:1.1.1.184 )
NADPH + Prostaglandin E2 => NADP+ + Prostaglandin F2alpha( EC:1.1.1.184 )
event
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200051
http://purl.org/obo/owl/IMR#IMR_0200051
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200146
http://purl.org/obo/owl/IMR#IMR_0200146
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
KEGG:map00590
http://purl.org/obo/owl/KEGG#KEGG_map00590
KEGG:R02581
http://purl.org/obo/owl/KEGG#KEGG_R02581
EC:1.1.1.184
http://purl.org/obo/owl/EC#EC_1.1.1.184
ATP + UTP + NH3 => ADP + CTP + Orthophosphate( EC:6.3.4.2 )
event
KEGG:R00571
http://purl.org/obo/owl/KEGG#KEGG_R00571
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:6.3.4.2
http://purl.org/obo/owl/EC#EC_6.3.4.2
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200199
http://purl.org/obo/owl/IMR#IMR_0200199
IMR:0200202
http://purl.org/obo/owl/IMR#IMR_0200202
dUTP + H2O => dUMP + Pyrophosphate( EC:3.6.1.23 )
event
IMR:0200056
http://purl.org/obo/owl/IMR#IMR_0200056
KEGG:R02100
http://purl.org/obo/owl/KEGG#KEGG_R02100
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200008
http://purl.org/obo/owl/IMR#IMR_0200008
EC:3.6.1.23
http://purl.org/obo/owl/EC#EC_3.6.1.23
L-Tryptophan + O2 => N-Formyl-L-kynurenine( EC:1.13.11.11 )
event
KEGG:R00678
http://purl.org/obo/owl/KEGG#KEGG_R00678
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
EC:1.13.11.11
http://purl.org/obo/owl/EC#EC_1.13.11.11
IMR:0200038
http://purl.org/obo/owl/IMR#IMR_0200038
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200307
http://purl.org/obo/owl/IMR#IMR_0200307
ATP + L-Aspartic acid + L-Citrulline => AMP + Pyrophosphate + L-Arginino-succinic acid( EC:6.3.4.5 )
event
IMR:0200391
http://purl.org/obo/owl/IMR#IMR_0200391
IMR:0200459
http://purl.org/obo/owl/IMR#IMR_0200459
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0200019
http://purl.org/obo/owl/IMR#IMR_0200019
EC:6.3.4.5
http://purl.org/obo/owl/EC#EC_6.3.4.5
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
KEGG:R01954
http://purl.org/obo/owl/KEGG#KEGG_R01954
dGTP + H2O => dGMP + Pyrophosphate( EC:3.6.1.19 )
event
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200505
http://purl.org/obo/owl/IMR#IMR_0200505
EC:3.6.1.19
http://purl.org/obo/owl/EC#EC_3.6.1.19
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200286
http://purl.org/obo/owl/IMR#IMR_0200286
KEGG:R01855
http://purl.org/obo/owl/KEGG#KEGG_R01855
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
dITP + H2O => dIMP + Pyrophosphate( EC:3.6.1.19 )
event
EC:3.6.1.19
http://purl.org/obo/owl/EC#EC_3.6.1.19
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200446
http://purl.org/obo/owl/IMR#IMR_0200446
IMR:0200122
http://purl.org/obo/owl/IMR#IMR_0200122
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R03531
http://purl.org/obo/owl/KEGG#KEGG_R03531
ATP + Tetrahydrofolate + Formic acid => ADP + 10-Formyl-tetrahydro-folic acid + Orthophosphate( EC:6.3.4.3 )
ATP + L-Tetrahydro-folic acid + Formic acid => ADP + 10-Formyl-tetrahydro-folic acid + Orthophosphate( EC:6.3.4.3 )
event
KEGG:map00670
http://purl.org/obo/owl/KEGG#KEGG_map00670
KEGG:map00630
http://purl.org/obo/owl/KEGG#KEGG_map00630
IMR:0200347
http://purl.org/obo/owl/IMR#IMR_0200347
KEGG:R00943
http://purl.org/obo/owl/KEGG#KEGG_R00943
EC:6.3.4.3
http://purl.org/obo/owl/EC#EC_6.3.4.3
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200110
http://purl.org/obo/owl/IMR#IMR_0200110
IMR:0200330
http://purl.org/obo/owl/IMR#IMR_0200330
dTDP + H2O => dTMP + Orthophosphate( EC:3.6.1.5 )
event
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200187
http://purl.org/obo/owl/IMR#IMR_0200187
IMR:0200338
http://purl.org/obo/owl/IMR#IMR_0200338
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
EC:3.6.1.5
http://purl.org/obo/owl/EC#EC_3.6.1.5
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:R02092
http://purl.org/obo/owl/KEGG#KEGG_R02092
ATP + 7,8-Dihydro-pteroic acid + L-Glutamic acid => ADP + 7,8-Dihydro-folic acid + Orthophosphate( EC:6.3.2.17 )
event
KEGG:R02237
http://purl.org/obo/owl/KEGG#KEGG_R02237
KEGG:map00790
http://purl.org/obo/owl/KEGG#KEGG_map00790
IMR:0200176
http://purl.org/obo/owl/IMR#IMR_0200176
IMR:0200185
http://purl.org/obo/owl/IMR#IMR_0200185
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
EC:6.3.2.17
http://purl.org/obo/owl/EC#EC_6.3.2.17
S-Adenosylmethioninamine + Putrescine => 5'-Methylthio-adenosine + Spermidine( EC:2.5.1.16 )
S-Adenosyl-L-methioninamine + Putrescine => 5'-Methylthio-adenosine + Spermidine( EC:2.5.1.16 )
event
IMR:0200153
http://purl.org/obo/owl/IMR#IMR_0200153
IMR:0200028
http://purl.org/obo/owl/IMR#IMR_0200028
EC:2.5.1.16
http://purl.org/obo/owl/EC#EC_2.5.1.16
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
KEGG:map00270
http://purl.org/obo/owl/KEGG#KEGG_map00270
IMR:0200285
http://purl.org/obo/owl/IMR#IMR_0200285
IMR:0200175
http://purl.org/obo/owl/IMR#IMR_0200175
KEGG:R01920
http://purl.org/obo/owl/KEGG#KEGG_R01920
KEGG:map00480
http://purl.org/obo/owl/KEGG#KEGG_map00480
ATP + Pyridoxamine => ADP + Pyridoxamine 5'-phosphate( EC:2.7.1.35 )
event
EC:2.7.1.35
http://purl.org/obo/owl/EC#EC_2.7.1.35
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200309
http://purl.org/obo/owl/IMR#IMR_0200309
IMR:0200382
http://purl.org/obo/owl/IMR#IMR_0200382
KEGG:map00750
http://purl.org/obo/owl/KEGG#KEGG_map00750
KEGG:R02493
http://purl.org/obo/owl/KEGG#KEGG_R02493
ATP + D-Mannose => ADP + D-Mannose 6-phosphate( EC:2.7.1.1 )
event
KEGG:R01326
http://purl.org/obo/owl/KEGG#KEGG_R01326
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:2.7.1.1
http://purl.org/obo/owl/EC#EC_2.7.1.1
IMR:0200053
http://purl.org/obo/owl/IMR#IMR_0200053
IMR:0200230
http://purl.org/obo/owl/IMR#IMR_0200230
KEGG:map00051
http://purl.org/obo/owl/KEGG#KEGG_map00051
Pyridoxal + O2 + H2O => 4-Pyridoxic acid + H2O2( EC:1.2.3.1 )
event
IMR:0200267
http://purl.org/obo/owl/IMR#IMR_0200267
EC:1.2.3.1
http://purl.org/obo/owl/EC#EC_1.2.3.1
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
KEGG:R01709
http://purl.org/obo/owl/KEGG#KEGG_R01709
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
IMR:0200504
http://purl.org/obo/owl/IMR#IMR_0200504
KEGG:map00750
http://purl.org/obo/owl/KEGG#KEGG_map00750
UDP + Reduced thioredoxin => dUDP + H2O + Oxidized thioredoxin( EC:1.17.4.1 )
event
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:R02018
http://purl.org/obo/owl/KEGG#KEGG_R02018
IMR:0200206
http://purl.org/obo/owl/IMR#IMR_0200206
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200108
http://purl.org/obo/owl/IMR#IMR_0200108
IMR:0200098
http://purl.org/obo/owl/IMR#IMR_0200098
IMR:0200133
http://purl.org/obo/owl/IMR#IMR_0200133
EC:1.17.4.1
http://purl.org/obo/owl/EC#EC_1.17.4.1
NADP+ + beta-D-Glucose 6-phosphate => NADPH + D-Glucono-1,5-lactone 6-phosphate + H+( EC:1.1.1.49 )
NADP+ + D-Glucose 6-phosphate => NADPH + D-6-Phospho-glucono 1,5-lactone( EC:1.1.1.49 )
event
KEGG:R02736
http://purl.org/obo/owl/KEGG#KEGG_R02736
KEGG:map00480
http://purl.org/obo/owl/KEGG#KEGG_map00480
KEGG:map00030
http://purl.org/obo/owl/KEGG#KEGG_map00030
KEGG:C01172
http://purl.org/obo/owl/KEGG#KEGG_C01172
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.1.1.49
http://purl.org/obo/owl/EC#EC_1.1.1.49
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200508
http://purl.org/obo/owl/IMR#IMR_0200508
CTP + N-Acetyl-neuraminic acid => Pyrophosphate + CMP-N-acetyl-neuraminic acid( EC:2.7.7.43 )
event
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
KEGG:R01117
http://purl.org/obo/owl/KEGG#KEGG_R01117
IMR:0200020
http://purl.org/obo/owl/IMR#IMR_0200020
EC:2.7.7.43
http://purl.org/obo/owl/EC#EC_2.7.7.43
IMR:0200202
http://purl.org/obo/owl/IMR#IMR_0200202
IMR:0200107
http://purl.org/obo/owl/IMR#IMR_0200107
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
ATP + L-Serine + tRNA(Ser) => AMP + L-Seryl-tRNA(Ser) + Pyrophosphate( EC:6.1.1.11 )
event
EC:6.1.1.11
http://purl.org/obo/owl/EC#EC_6.1.1.11
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
KEGG:R03662
http://purl.org/obo/owl/KEGG#KEGG_R03662
KEGG:map00970
http://purl.org/obo/owl/KEGG#KEGG_map00970
IMR:0200268
http://purl.org/obo/owl/IMR#IMR_0200268
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200379
http://purl.org/obo/owl/IMR#IMR_0200379
IMR:0200453
http://purl.org/obo/owl/IMR#IMR_0200453
Glycine + H2O + O2 => Glyoxylic acid + NH3 + H2O2( EC:1.4.3.3 )
event
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200184
http://purl.org/obo/owl/IMR#IMR_0200184
KEGG:R00366
http://purl.org/obo/owl/KEGG#KEGG_R00366
EC:1.4.3.3
http://purl.org/obo/owl/EC#EC_1.4.3.3
IMR:0100118
http://purl.org/obo/owl/IMR#IMR_0100118
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
S-Adenosyl-L-methionine + L-Noradrenaline => S-Adenosyl-L-homocysteine + L-Normetanephrine( EC:2.1.1.6 )
event
IMR:0100115
http://purl.org/obo/owl/IMR#IMR_0100115
IMR:0200054
http://purl.org/obo/owl/IMR#IMR_0200054
EC:2.1.1.6
http://purl.org/obo/owl/EC#EC_2.1.1.6
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
KEGG:R02534
http://purl.org/obo/owl/KEGG#KEGG_R02534
IMR:0200151
http://purl.org/obo/owl/IMR#IMR_0200151
IMR:0200388
http://purl.org/obo/owl/IMR#IMR_0200388
Serotonin + H2O + O2 => 5-Hydroxy-indole-acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
event
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:R02908
http://purl.org/obo/owl/KEGG#KEGG_R02908
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
IMR:0100123
http://purl.org/obo/owl/IMR#IMR_0100123
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200353
http://purl.org/obo/owl/IMR#IMR_0200353
EC:1.4.3.4
http://purl.org/obo/owl/EC#EC_1.4.3.4
S-Adenosyl-L-methionine + Dopamine => S-Adenosyl-L-homocysteine + 3-Methoxy-tyramine( EC:2.1.1.6 )
event
KEGG:map00965
http://purl.org/obo/owl/KEGG#KEGG_map00965
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
KEGG:R04301
http://purl.org/obo/owl/KEGG#KEGG_R04301
EC:2.1.1.6
http://purl.org/obo/owl/EC#EC_2.1.1.6
IMR:0200009
http://purl.org/obo/owl/IMR#IMR_0200009
IMR:0100113
http://purl.org/obo/owl/IMR#IMR_0100113
IMR:0200151
http://purl.org/obo/owl/IMR#IMR_0200151
IMR:0200054
http://purl.org/obo/owl/IMR#IMR_0200054
ADP + H2O => AMP + Orthophosphate( EC:3.6.1.5 )
event
EC:3.6.1.5
http://purl.org/obo/owl/EC#EC_3.6.1.5
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R00122
http://purl.org/obo/owl/KEGG#KEGG_R00122
ATP => 3',5'-Cyclic AMP + Pyrophosphate( EC:4.6.1.1 )
event
EC:4.6.1.1
http://purl.org/obo/owl/EC#EC_4.6.1.1
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0100024
http://purl.org/obo/owl/IMR#IMR_0100024
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R00089
http://purl.org/obo/owl/KEGG#KEGG_R00089
L-Homocysteine + L-Serine => L-Cystathionine + H2O( EC:4.2.1.22 )
event
KEGG:map00270
http://purl.org/obo/owl/KEGG#KEGG_map00270
KEGG:R01290
http://purl.org/obo/owl/KEGG#KEGG_R01290
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
EC:4.2.1.22
http://purl.org/obo/owl/EC#EC_4.2.1.22
IMR:0200453
http://purl.org/obo/owl/IMR#IMR_0200453
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200220
http://purl.org/obo/owl/IMR#IMR_0200220
IMR:0200039
http://purl.org/obo/owl/IMR#IMR_0200039
NADPH + 7,8-Dihydro-folic acid + H+ => NADP+ + Tetrahydrofolate( EC:1.5.1.3 )
NADPH + 7,8-Dihydro-folic acid => NADP+ + L-Tetrahydro-folic acid( EC:1.5.1.3 )
event
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
KEGG:map00670
http://purl.org/obo/owl/KEGG#KEGG_map00670
KEGG:map00790
http://purl.org/obo/owl/KEGG#KEGG_map00790
KEGG:R00939
http://purl.org/obo/owl/KEGG#KEGG_R00939
IMR:0200185
http://purl.org/obo/owl/IMR#IMR_0200185
IMR:0200330
http://purl.org/obo/owl/IMR#IMR_0200330
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
EC:1.5.1.3
http://purl.org/obo/owl/EC#EC_1.5.1.3
ATP + beta-D-Glucose => ADP + beta-D-Glucose 6-phosphate( EC:2.7.1.1 )
ATP + D-Glucose => ADP + D-Glucose 6-phosphate( EC:2.7.1.1 )
event
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
KEGG:C00221
http://purl.org/obo/owl/KEGG#KEGG_C00221
KEGG:C01172
http://purl.org/obo/owl/KEGG#KEGG_C01172
EC:2.7.1.1
http://purl.org/obo/owl/EC#EC_2.7.1.1
KEGG:map00010
http://purl.org/obo/owl/KEGG#KEGG_map00010
KEGG:R01600
http://purl.org/obo/owl/KEGG#KEGG_R01600
Pyridoxamine 5'-phosphate + O2 + H2O => Pyridoxal 5'-phosphate + H2O2 + NH3( EC:1.4.3.5 )
event
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
IMR:0200229
http://purl.org/obo/owl/IMR#IMR_0200229
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200309
http://purl.org/obo/owl/IMR#IMR_0200309
KEGG:map00750
http://purl.org/obo/owl/KEGG#KEGG_map00750
KEGG:R00277
http://purl.org/obo/owl/KEGG#KEGG_R00277
EC:1.4.3.5
http://purl.org/obo/owl/EC#EC_1.4.3.5
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
GTP + H2O => GDP + Orthophosphate( EC:3.6.1.5 )
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
EC:3.6.1.5
http://purl.org/obo/owl/EC#EC_3.6.1.5
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:R00335
http://purl.org/obo/owl/KEGG#KEGG_R00335
Dopamine + L-Ascorbic acid + O2 => L-Noradrenaline + L-Dehydro-ascorbic acid + H2O( EC:1.14.17.1 )
event
IMR:0100113
http://purl.org/obo/owl/IMR#IMR_0100113
EC:1.14.17.1
http://purl.org/obo/owl/EC#EC_1.14.17.1
IMR:0200196
http://purl.org/obo/owl/IMR#IMR_0200196
IMR:0100115
http://purl.org/obo/owl/IMR#IMR_0100115
KEGG:R02535
http://purl.org/obo/owl/KEGG#KEGG_R02535
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200293
http://purl.org/obo/owl/IMR#IMR_0200293
ATP + L-Histidine + tRNA(His) => AMP + L-Histidyl-tRNA(His) + Pyrophosphate( EC:6.1.1.21 )
event
IMR:0200137
http://purl.org/obo/owl/IMR#IMR_0200137
IMR:0200135
http://purl.org/obo/owl/IMR#IMR_0200135
KEGG:map00970
http://purl.org/obo/owl/KEGG#KEGG_map00970
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
KEGG:R03655
http://purl.org/obo/owl/KEGG#KEGG_R03655
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:6.1.1.21
http://purl.org/obo/owl/EC#EC_6.1.1.21
IMR:0200106
http://purl.org/obo/owl/IMR#IMR_0200106
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
NAD+ + L-1-Pyrroline-3-hydroxy-5-carboxylic acid + 2 H2O => NADH + L-erythro-4-Hydroxy-glutamic acid + H+( EC:1.5.1.12 )
NAD+ + L-1-Pyrroline-3-hydroxy-5-carboxylic acid + 2 H2O => NADH + L-erythro-4-Hydroxy-glutamic acid( EC:1.5.1.12 )
event
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:R04444
http://purl.org/obo/owl/KEGG#KEGG_R04444
IMR:0200225
http://purl.org/obo/owl/IMR#IMR_0200225
IMR:0200091
http://purl.org/obo/owl/IMR#IMR_0200091
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.5.1.12
http://purl.org/obo/owl/EC#EC_1.5.1.12
Uroporphyrinogen III => Coproporphyrinogen III + 4 CO2( EC:4.1.1.37 )
event
IMR:0200315
http://purl.org/obo/owl/IMR#IMR_0200315
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
EC:4.1.1.37
http://purl.org/obo/owl/EC#EC_4.1.1.37
IMR:0200258
http://purl.org/obo/owl/IMR#IMR_0200258
KEGG:map00860
http://purl.org/obo/owl/KEGG#KEGG_map00860
KEGG:R03197
http://purl.org/obo/owl/KEGG#KEGG_R03197
ATP + N-Acetyl-D-glucosamine => ADP + N-Acetyl-D-glucosamine 6-phosphate( EC:2.7.1.59 )
event
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200374
http://purl.org/obo/owl/IMR#IMR_0200374
IMR:0200259
http://purl.org/obo/owl/IMR#IMR_0200259
KEGG:R01201
http://purl.org/obo/owl/KEGG#KEGG_R01201
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
EC:2.7.1.59
http://purl.org/obo/owl/EC#EC_2.7.1.59
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
2 NADPH + Folic acid + 2 H+ => 2 NADP+ + Tetrahydrofolate( EC:1.5.1.3 )
NADPH + Folic acid => NADP+ + L-Tetrahydro-folic acid( EC:1.5.1.3 ):two-step reaction
event
IMR:0200356
http://purl.org/obo/owl/IMR#IMR_0200356
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
KEGG:map00790
http://purl.org/obo/owl/KEGG#KEGG_map00790
KEGG:R00940
http://purl.org/obo/owl/KEGG#KEGG_R00940
EC:1.5.1.3
http://purl.org/obo/owl/EC#EC_1.5.1.3
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200330
http://purl.org/obo/owl/IMR#IMR_0200330
Xanthine + H2O + O2 => Uric acid + H2O2( EC:1.17.3.2 )
event
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R02107
http://purl.org/obo/owl/KEGG#KEGG_R02107
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
EC:1.17.3.2
http://purl.org/obo/owl/EC#EC_1.17.3.2
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200029
http://purl.org/obo/owl/IMR#IMR_0200029
IMR:0200439
http://purl.org/obo/owl/IMR#IMR_0200439
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
S-Adenosyl-L-methionine + Glycine => S-Adenosyl-L-homocysteine + Sarcosine( EC:2.1.1.20 )
event
IMR:0200189
http://purl.org/obo/owl/IMR#IMR_0200189
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
IMR:0200054
http://purl.org/obo/owl/IMR#IMR_0200054
IMR:0200151
http://purl.org/obo/owl/IMR#IMR_0200151
EC:2.1.1.20
http://purl.org/obo/owl/EC#EC_2.1.1.20
IMR:0100118
http://purl.org/obo/owl/IMR#IMR_0100118
KEGG:R00367
http://purl.org/obo/owl/KEGG#KEGG_R00367
10-Formyl-tetrahydro-folic acid + 5'-Phospho-ribosyl-glycinamide => Tetrahydrofolate + 5'-Phospho-ribosyl-N-formyl-glycinamide( EC:2.1.2.2 )
10-Formyl-tetrahydro-folic acid + 5'-Phospho-ribosyl-glycinamide => L-Tetrahydro-folic acid + 5'-Phospho-ribosyl-N-formyl-glycinamide( EC:2.1.2.2 )
event
KEGG:R04325
http://purl.org/obo/owl/KEGG#KEGG_R04325
KEGG:map00670
http://purl.org/obo/owl/KEGG#KEGG_map00670
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
EC:2.1.2.2
http://purl.org/obo/owl/EC#EC_2.1.2.2
IMR:0200330
http://purl.org/obo/owl/IMR#IMR_0200330
IMR:0200347
http://purl.org/obo/owl/IMR#IMR_0200347
IMR:0200022
http://purl.org/obo/owl/IMR#IMR_0200022
IMR:0200252
http://purl.org/obo/owl/IMR#IMR_0200252
4-Hydroxy-phenyl-pyruvic acid + O2 => CO2 + 2,5-Dihydroxy-phenyl-acetic acid( EC:1.13.11.27 )
event
IMR:0200341
http://purl.org/obo/owl/IMR#IMR_0200341
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200254
http://purl.org/obo/owl/IMR#IMR_0200254
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
EC:1.13.11.27
http://purl.org/obo/owl/EC#EC_1.13.11.27
KEGG:R02521
http://purl.org/obo/owl/KEGG#KEGG_R02521
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
KEGG:map00130
http://purl.org/obo/owl/KEGG#KEGG_map00130
dAMP + H2O => Deoxy-adenosine + Orthophosphate( EC:3.1.3.5 )
event
EC:3.1.3.5
http://purl.org/obo/owl/EC#EC_3.1.3.5
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200160
http://purl.org/obo/owl/IMR#IMR_0200160
IMR:0200226
http://purl.org/obo/owl/IMR#IMR_0200226
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R02088
http://purl.org/obo/owl/KEGG#KEGG_R02088
ATP + L-Methionine + H2O => S-Adenosyl-L-methionine + Pyrophosphate + Orthophosphate( EC:2.5.1.6 )
event
EC:2.5.1.6
http://purl.org/obo/owl/EC#EC_2.5.1.6
KEGG:R00177
http://purl.org/obo/owl/KEGG#KEGG_R00177
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
KEGG:map00270
http://purl.org/obo/owl/KEGG#KEGG_map00270
IMR:0200488
http://purl.org/obo/owl/IMR#IMR_0200488
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200054
http://purl.org/obo/owl/IMR#IMR_0200054
L-2-Amino-3-oxo-butanoic acid => Amino-acetone + CO2( nonenzymatic )
event
KEGG:R03758
http://purl.org/obo/owl/KEGG#KEGG_R03758
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
KEGG:C03508
http://purl.org/obo/owl/KEGG#KEGG_C03508
IMR:0200360
http://purl.org/obo/owl/IMR#IMR_0200360
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
N-Acetyl-D-mannosamine 6-phosphate + Phosphoenol-pyruvic acid + H2O => N-Acetyl-neuraminate 9-phosphate + Orthophosphate( EC:2.5.1.57 )
event
KEGG:R04435
http://purl.org/obo/owl/KEGG#KEGG_R04435
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
EC:2.5.1.57
http://purl.org/obo/owl/EC#EC_2.5.1.57
IMR:0200518
http://purl.org/obo/owl/IMR#IMR_0200518
IMR:0200223
http://purl.org/obo/owl/IMR#IMR_0200223
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200279
http://purl.org/obo/owl/IMR#IMR_0200279
Amino-acetone + H2O + O2 => Methyl-glyoxal + NH3 + H2O2( EC:1.4.3.4 )
event
IMR:0200360
http://purl.org/obo/owl/IMR#IMR_0200360
IMR:0200471
http://purl.org/obo/owl/IMR#IMR_0200471
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:R02529
http://purl.org/obo/owl/KEGG#KEGG_R02529
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
EC:1.4.3.4
http://purl.org/obo/owl/EC#EC_1.4.3.4
UDP-N-acetyl-D-glucosamine => UDP-N-acetyl-D-mannosamine( EC:5.1.3.14 )
event
KEGG:R00420
http://purl.org/obo/owl/KEGG#KEGG_R00420
IMR:0200247
http://purl.org/obo/owl/IMR#IMR_0200247
KEGG:map00520
http://purl.org/obo/owl/KEGG#KEGG_map00520
EC:5.1.3.14
http://purl.org/obo/owl/EC#EC_5.1.3.14
IMR:0200162
http://purl.org/obo/owl/IMR#IMR_0200162
NADH + (S)-Methyl-malonate semialdehyde + H+ => NAD+ + (S)-3-Hydroxyisobutyrate( EC:1.1.1.31 )
NADH + (S)-Methyl-malonate semialdehyde => NAD+ + (S)-3-Hydroxy-2-methyl-propanoic acid( EC:1.1.1.31 )
event
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200297
http://purl.org/obo/owl/IMR#IMR_0200297
IMR:0200385
http://purl.org/obo/owl/IMR#IMR_0200385
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
EC:1.1.1.31
http://purl.org/obo/owl/EC#EC_1.1.1.31
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
KEGG:R05066
http://purl.org/obo/owl/KEGG#KEGG_R05066
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
NAD+ + (S)-Methyl-malonate semialdehyde + H2O => NADH + Methyl-malonic acid + H+( EC:1.2.1.3 )
NAD+ + (S)-Methyl-malonate semialdehyde + H2O => NADH + Methyl-malonic acid( EC:1.2.1.3 )
event
EC:1.2.1.3
http://purl.org/obo/owl/EC#EC_1.2.1.3
KEGG:R03869
http://purl.org/obo/owl/KEGG#KEGG_R03869
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200297
http://purl.org/obo/owl/IMR#IMR_0200297
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200163
http://purl.org/obo/owl/IMR#IMR_0200163
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
NADH + L-Lysine + 2-Oxo-glutaric acid + H+ => NAD+ + L-Saccharopine + H2O( EC:1.5.1.7 )
NADH + L-Lysine + 2-Oxo-glutaric acid => NAD+ + L-Saccharopine + H2O( EC:1.5.1.7 )
event
IMR:0200155
http://purl.org/obo/owl/IMR#IMR_0200155
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200140
http://purl.org/obo/owl/IMR#IMR_0200140
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:map00300
http://purl.org/obo/owl/KEGG#KEGG_map00300
KEGG:map00310
http://purl.org/obo/owl/KEGG#KEGG_map00310
EC:1.5.1.7
http://purl.org/obo/owl/EC#EC_1.5.1.7
KEGG:R00715
http://purl.org/obo/owl/KEGG#KEGG_R00715
NADP+ + H2O => Nicotinamide + ADPribose 2'-phosphate( EC:3.2.2.5 )
event
EC:3.2.2.5
http://purl.org/obo/owl/EC#EC_3.2.2.5
IMR:0200314
http://purl.org/obo/owl/IMR#IMR_0200314
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200025
http://purl.org/obo/owl/IMR#IMR_0200025
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
KEGG:R00119
http://purl.org/obo/owl/KEGG#KEGG_R00119
KEGG:map00760
http://purl.org/obo/owl/KEGG#KEGG_map00760
3-Methoxy-tyramine + H2O + O2 => 3-methoxy-4-hydroxy-phenyl-acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
event
EC:1.4.3.4
http://purl.org/obo/owl/EC#EC_1.4.3.4
KEGG:R04890
http://purl.org/obo/owl/KEGG#KEGG_R04890
KEGG:map00350
http://purl.org/obo/owl/KEGG#KEGG_map00350
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
IMR:0200383
http://purl.org/obo/owl/IMR#IMR_0200383
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0200009
http://purl.org/obo/owl/IMR#IMR_0200009
2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydro-pteridine triphosphate => 6-Pyruvoyl-5,6,7,8-tetrahydro-pterin + Triphosphate( EC:4.2.3.12 )
event
IMR:0200063
http://purl.org/obo/owl/IMR#IMR_0200063
IMR:0200358
http://purl.org/obo/owl/IMR#IMR_0200358
KEGG:R04286
http://purl.org/obo/owl/KEGG#KEGG_R04286
IMR:0200406
http://purl.org/obo/owl/IMR#IMR_0200406
KEGG:map00790
http://purl.org/obo/owl/KEGG#KEGG_map00790
EC:4.2.3.12
http://purl.org/obo/owl/EC#EC_4.2.3.12
2-Oxo-glutaric acid + O-Phospho-4-hydroxy-L-threonine = L-Glutamic acid + 2-Oxo-3-hydroxy-4-phospho-butanoic acid( EC:2.6.1.52 )
event
KEGG:R05085
http://purl.org/obo/owl/KEGG#KEGG_R05085
KEGG:map00750
http://purl.org/obo/owl/KEGG#KEGG_map00750
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
IMR:0200257
http://purl.org/obo/owl/IMR#IMR_0200257
EC:2.6.1.52
http://purl.org/obo/owl/EC#EC_2.6.1.52
IMR:0200181
http://purl.org/obo/owl/IMR#IMR_0200181
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
Isopentenyl diphosphate + Dimethylallyl diphosphate => Geranyl diphosphate + Pyrophosphate( EC:2.5.1.1 )
event
KEGG:R01658
http://purl.org/obo/owl/KEGG#KEGG_R01658
EC:2.5.1.1
http://purl.org/obo/owl/EC#EC_2.5.1.1
IMR:0200287
http://purl.org/obo/owl/IMR#IMR_0200287
IMR:0200399
http://purl.org/obo/owl/IMR#IMR_0200399
IMR:0200094
http://purl.org/obo/owl/IMR#IMR_0200094
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
KEGG:map00900
http://purl.org/obo/owl/KEGG#KEGG_map00900
P1,P4-Bis(5'-xanthosyl) tetraphosphate + H2O => XTP + XMP( EC:3.6.1.17 )
event
IMR:0200490
http://purl.org/obo/owl/IMR#IMR_0200490
IMR:0200425
http://purl.org/obo/owl/IMR#IMR_0200425
KEGG:R02805
http://purl.org/obo/owl/KEGG#KEGG_R02805
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
EC:3.6.1.17
http://purl.org/obo/owl/EC#EC_3.6.1.17
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200165
http://purl.org/obo/owl/IMR#IMR_0200165
GTP + H2O => GMP + Pyrophosphate( EC:3.6.1.19 )
event
EC:3.6.1.19
http://purl.org/obo/owl/EC#EC_3.6.1.19
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200292
http://purl.org/obo/owl/IMR#IMR_0200292
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R00426
http://purl.org/obo/owl/KEGG#KEGG_R00426
NAD+ + L-Glutamate 5-semialdehyde + H2O => NADH + L-Glutamic acid + H+( EC:1.5.1.12 )
NAD+ + L-Glutamate 5-semialdehyde + H2O => NADH + L-Glutamic acid( EC:1.5.1.12 )
event
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200205
http://purl.org/obo/owl/IMR#IMR_0200205
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
EC:1.5.1.12
http://purl.org/obo/owl/EC#EC_1.5.1.12
KEGG:R00245
http://purl.org/obo/owl/KEGG#KEGG_R00245
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
5-Hydroxy-indole-acetaldehyde + H2O + O2 => 5-Hydroxy-indole-acetic acid + H2O2( EC:1.2.3.1 )
event
KEGG:R04904
http://purl.org/obo/owl/KEGG#KEGG_R04904
IMR:0200052
http://purl.org/obo/owl/IMR#IMR_0200052
EC:1.2.3.1
http://purl.org/obo/owl/EC#EC_1.2.3.1
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
KEGG:map00380
http://purl.org/obo/owl/KEGG#KEGG_map00380
IMR:0200353
http://purl.org/obo/owl/IMR#IMR_0200353
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
L-Histidine = Urocanic acid + NH3( EC:4.3.1.3 )
event
KEGG:R01168
http://purl.org/obo/owl/KEGG#KEGG_R01168
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
EC:4.3.1.3
http://purl.org/obo/owl/EC#EC_4.3.1.3
KEGG:map00340
http://purl.org/obo/owl/KEGG#KEGG_map00340
KEGG:map00910
http://purl.org/obo/owl/KEGG#KEGG_map00910
IMR:0200137
http://purl.org/obo/owl/IMR#IMR_0200137
IMR:0200337
http://purl.org/obo/owl/IMR#IMR_0200337
L-Glutamic acid => 4-Amino-butanoic acid + CO2( EC:4.1.1.15 )
event
EC:4.1.1.15
http://purl.org/obo/owl/EC#EC_4.1.1.15
IMR:0100117
http://purl.org/obo/owl/IMR#IMR_0100117
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
KEGG:map00650
http://purl.org/obo/owl/KEGG#KEGG_map00650
KEGG:R00261
http://purl.org/obo/owl/KEGG#KEGG_R00261
dCMP + H2O => Deoxy-cytidine + Orthophosphate( EC:3.1.3.5 )
event
IMR:0200390
http://purl.org/obo/owl/IMR#IMR_0200390
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200005
http://purl.org/obo/owl/IMR#IMR_0200005
KEGG:R01664
http://purl.org/obo/owl/KEGG#KEGG_R01664
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
EC:3.1.3.5
http://purl.org/obo/owl/EC#EC_3.1.3.5
ATP + 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate + L-Aspartic acid => ADP + 5'-Phospho-ribosyl-4-(N-succino-carboxamide)-5-amino-imidazole + Orthophosphate( EC:6.3.2.6 )
ATP + 5'-Phospho-ribosyl-5-amino-imidazole-4-carboxylic acid + L-Aspartic acid => ADP + 5'-Phospho-ribosyl-4-(N-succino-carboxamide)-5-amino-imidazole + Orthophosphate( EC:6.3.2.6 )
event
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:6.3.2.6
http://purl.org/obo/owl/EC#EC_6.3.2.6
KEGG:R04591
http://purl.org/obo/owl/KEGG#KEGG_R04591
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200459
http://purl.org/obo/owl/IMR#IMR_0200459
IMR:0200422
http://purl.org/obo/owl/IMR#IMR_0200422
IMR:0200213
http://purl.org/obo/owl/IMR#IMR_0200213
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
NADP+ + H2O => NAD+ + Orthophosphate( EC:3.1.3.- )
event
KEGG:R00118
http://purl.org/obo/owl/KEGG#KEGG_R00118
KEGG:map00760
http://purl.org/obo/owl/KEGG#KEGG_map00760
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
EC:3.1.3.-
http://purl.org/obo/owl/EC#EC_3.1.3.-
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
3-Mercapto-pyruvic acid + Sulfite => Pyruvic acid + Thiosulfate( EC:2.8.1.2 )
3-Mercapto-pyruvic acid + Hydrogen cyanide => Pyruvic acid + Thiocyanic acid( EC:2.8.1.2 )
event
KEGG:map00270
http://purl.org/obo/owl/KEGG#KEGG_map00270
KEGG:R03105
http://purl.org/obo/owl/KEGG#KEGG_R03105
EC:2.8.1.2
http://purl.org/obo/owl/EC#EC_2.8.1.2
KEGG:C00094
http://purl.org/obo/owl/KEGG#KEGG_C00094
KEGG:C00320
http://purl.org/obo/owl/KEGG#KEGG_C00320
IMR:0200007
http://purl.org/obo/owl/IMR#IMR_0200007
IMR:0200331
http://purl.org/obo/owl/IMR#IMR_0200331
Carnosine + H2O => L-Histidine + beta-Alanine( EC:3.4.13.20 )
L-Carnosine + H2O => L-Histidine + beta-Alanine( EC:3.4.13.20 )
event
KEGG:map00340
http://purl.org/obo/owl/KEGG#KEGG_map00340
KEGG:map00410
http://purl.org/obo/owl/KEGG#KEGG_map00410
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200438
http://purl.org/obo/owl/IMR#IMR_0200438
IMR:0200137
http://purl.org/obo/owl/IMR#IMR_0200137
EC:3.4.13.20
http://purl.org/obo/owl/EC#EC_3.4.13.20
IMR:0200178
http://purl.org/obo/owl/IMR#IMR_0200178
KEGG:R01166
http://purl.org/obo/owl/KEGG#KEGG_R01166
ATP + 1D-myo-Inositol 1,4,5-trisphosphate => ADP + 1D-myo-Inositol 1,3,4,5-tetrakisphosphate( EC:2.7.1.127 )
event
IMR:0100029
http://purl.org/obo/owl/IMR#IMR_0100029
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
KEGG:map04070
http://purl.org/obo/owl/KEGG#KEGG_map04070
KEGG:R03433
http://purl.org/obo/owl/KEGG#KEGG_R03433
EC:2.7.1.127
http://purl.org/obo/owl/EC#EC_2.7.1.127
IMR:0100028
http://purl.org/obo/owl/IMR#IMR_0100028
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
ATP + L-Aspartic acid + tRNA(Asp) => AMP + L-Aspartyl-tRNA(Asp) + Pyrophosphate( EC:6.1.1.12 )
event
KEGG:map00970
http://purl.org/obo/owl/KEGG#KEGG_map00970
KEGG:R05577
http://purl.org/obo/owl/KEGG#KEGG_R05577
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200459
http://purl.org/obo/owl/IMR#IMR_0200459
IMR:0200249
http://purl.org/obo/owl/IMR#IMR_0200249
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0200006
http://purl.org/obo/owl/IMR#IMR_0200006
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:6.1.1.12
http://purl.org/obo/owl/EC#EC_6.1.1.12
ATP + Thymidine => ADP + dTMP( EC:2.7.1.21 )
event
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
EC:2.7.1.21
http://purl.org/obo/owl/EC#EC_2.7.1.21
IMR:0200384
http://purl.org/obo/owl/IMR#IMR_0200384
IMR:0200187
http://purl.org/obo/owl/IMR#IMR_0200187
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
KEGG:R01567
http://purl.org/obo/owl/KEGG#KEGG_R01567
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
1D-myo-Inositol 1,3,4-trisphosphate + H2O => 1D-myo-Inositol 3,4-bisphosphate + Orthophosphate( EC:3.1.3.57 )
event
IMR:0200334
http://purl.org/obo/owl/IMR#IMR_0200334
IMR:0200124
http://purl.org/obo/owl/IMR#IMR_0200124
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
EC:3.1.3.57
http://purl.org/obo/owl/EC#EC_3.1.3.57
KEGG:map04070
http://purl.org/obo/owl/KEGG#KEGG_map04070
KEGG:map00562
http://purl.org/obo/owl/KEGG#KEGG_map00562
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:R03427
http://purl.org/obo/owl/KEGG#KEGG_R03427
CTP + H2O => CDP + Orthophosphate( EC:3.6.1.5 )
event
EC:3.6.1.5
http://purl.org/obo/owl/EC#EC_3.6.1.5
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:R00569
http://purl.org/obo/owl/KEGG#KEGG_R00569
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200468
http://purl.org/obo/owl/IMR#IMR_0200468
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200202
http://purl.org/obo/owl/IMR#IMR_0200202
NAD+ + Imidazole-4-acetaldehyde + H2O = NADH + Imidazole-4-acetic acid + H+( EC:1.2.1.3 )
NAD+ + Imidazole-4-acetaldehyde + H2O = NADH + Imidazole-4-acetic acid( EC:1.2.1.3 )
event
KEGG:R04065
http://purl.org/obo/owl/KEGG#KEGG_R04065
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
KEGG:map00340
http://purl.org/obo/owl/KEGG#KEGG_map00340
IMR:0200352
http://purl.org/obo/owl/IMR#IMR_0200352
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0200321
http://purl.org/obo/owl/IMR#IMR_0200321
EC:1.2.1.3
http://purl.org/obo/owl/EC#EC_1.2.1.3
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
Phosphatidylserine => Phosphatidyl-ethanolamine + CO2( EC:4.1.1.65 )
O-Phosphatidyl-L-serine => Phosphatidyl-ethanolamine + CO2( EC:4.1.1.65 )
event
KEGG:R02055
http://purl.org/obo/owl/KEGG#KEGG_R02055
KEGG:map00564
http://purl.org/obo/owl/KEGG#KEGG_map00564
IMR:0001358
http://purl.org/obo/owl/IMR#IMR_0001358
EC:4.1.1.65
http://purl.org/obo/owl/EC#EC_4.1.1.65
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
IMR:0200317
http://purl.org/obo/owl/IMR#IMR_0200317
IMP + H2O => Inosine + Orthophosphate( EC:3.1.3.5 )
event
IMR:0200221
http://purl.org/obo/owl/IMR#IMR_0200221
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R01126
http://purl.org/obo/owl/KEGG#KEGG_R01126
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
EC:3.1.3.5
http://purl.org/obo/owl/EC#EC_3.1.3.5
IMR:0200194
http://purl.org/obo/owl/IMR#IMR_0200194
D-Aspartic acid + H2O + O2 => Oxaloacetic acid + NH3 + H2O2( EC:1.4.3.1 )
event
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
EC:1.4.3.1
http://purl.org/obo/owl/EC#EC_1.4.3.1
KEGG:R00359
http://purl.org/obo/owl/KEGG#KEGG_R00359
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
IMR:0200487
http://purl.org/obo/owl/IMR#IMR_0200487
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200126
http://purl.org/obo/owl/IMR#IMR_0200126
IMR:0200339
http://purl.org/obo/owl/IMR#IMR_0200339
ATP + 5-Formyl-tetrahydro-folic acid + H+ => ADP + 5,10-Methenyl-tetrahydro-folic acid + Orthophosphate( EC:6.3.3.2 )
ATP + 5-Formyl-tetrahydro-folic acid => ADP + 5,10-Methenyl-tetrahydro-folic acid + Orthophosphate( EC:6.3.3.2 )
event
KEGG:map00670
http://purl.org/obo/owl/KEGG#KEGG_map00670
KEGG:R02301
http://purl.org/obo/owl/KEGG#KEGG_R02301
IMR:0200159
http://purl.org/obo/owl/IMR#IMR_0200159
IMR:0200512
http://purl.org/obo/owl/IMR#IMR_0200512
EC:6.3.3.2
http://purl.org/obo/owl/EC#EC_6.3.3.2
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
dTTP + H2O => dTDP + Orthophosphate( EC:3.6.1.5 )
event
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200338
http://purl.org/obo/owl/IMR#IMR_0200338
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
KEGG:R02095
http://purl.org/obo/owl/KEGG#KEGG_R02095
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
IMR:0200084
http://purl.org/obo/owl/IMR#IMR_0200084
EC:3.6.1.5
http://purl.org/obo/owl/EC#EC_3.6.1.5
S-Adenosyl-L-methionine + H+ => S-Adenosylmethioninamine + CO2( EC:4.1.1.50 )
S-Adenosyl-L-methionine => S-Adenosyl-L-methioninamine + CO2( EC:4.1.1.50 )
event
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
IMR:0200054
http://purl.org/obo/owl/IMR#IMR_0200054
IMR:0200285
http://purl.org/obo/owl/IMR#IMR_0200285
EC:4.1.1.50
http://purl.org/obo/owl/EC#EC_4.1.1.50
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
KEGG:map00270
http://purl.org/obo/owl/KEGG#KEGG_map00270
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
KEGG:R00178
http://purl.org/obo/owl/KEGG#KEGG_R00178
S-Adenosyl-L-methionine + Nicotinamide + H+ => S-Adenosyl-L-homocysteine + 1-Methyl-nicotinamide( EC:2.1.1.1 )
S-Adenosyl-L-methionine + Nicotinamide => S-Adenosyl-L-homocysteine + 1-Methyl-nicotinamide( EC:2.1.1.1 )
event
IMR:0200188
http://purl.org/obo/owl/IMR#IMR_0200188
KEGG:map00760
http://purl.org/obo/owl/KEGG#KEGG_map00760
KEGG:R01269
http://purl.org/obo/owl/KEGG#KEGG_R01269
IMR:0200025
http://purl.org/obo/owl/IMR#IMR_0200025
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200054
http://purl.org/obo/owl/IMR#IMR_0200054
IMR:0200151
http://purl.org/obo/owl/IMR#IMR_0200151
EC:2.1.1.1
http://purl.org/obo/owl/EC#EC_2.1.1.1
ATP + (R)-Mevalonic acid => ADP + (R)-Mevalonic acid 5-phosphate( EC:2.7.1.36 )
event
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200118
http://purl.org/obo/owl/IMR#IMR_0200118
IMR:0200139
http://purl.org/obo/owl/IMR#IMR_0200139
KEGG:map00900
http://purl.org/obo/owl/KEGG#KEGG_map00900
KEGG:R02245
http://purl.org/obo/owl/KEGG#KEGG_R02245
EC:2.7.1.36
http://purl.org/obo/owl/EC#EC_2.7.1.36
ATP + Acetyl-CoA + HCO3- = ADP + Malonyl-CoA + Orthophosphate( EC:6.4.1.2 )
ATP + Acetyl-CoA + CO2 + H2O = ADP + Malonyl-CoA + Orthophosphate( EC:6.4.1.2 )
event
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
EC:6.4.1.2
http://purl.org/obo/owl/EC#EC_6.4.1.2
KEGG:C00288
http://purl.org/obo/owl/KEGG#KEGG_C00288
IMR:0200464
http://purl.org/obo/owl/IMR#IMR_0200464
IMR:0200414
http://purl.org/obo/owl/IMR#IMR_0200414
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
KEGG:R00742
http://purl.org/obo/owl/KEGG#KEGG_R00742
KEGG:map00640
http://purl.org/obo/owl/KEGG#KEGG_map00640
KEGG:map00620
http://purl.org/obo/owl/KEGG#KEGG_map00620
KEGG:map00253
http://purl.org/obo/owl/KEGG#KEGG_map00253
NADP+ + 5,10-Methylene-tetrahydro-folic acid = NADPH + 5,10-Methenyl-tetrahydro-folic acid( EC:1.5.1.5 )
event
EC:1.5.1.5
http://purl.org/obo/owl/EC#EC_1.5.1.5
KEGG:map00630
http://purl.org/obo/owl/KEGG#KEGG_map00630
KEGG:map00670
http://purl.org/obo/owl/KEGG#KEGG_map00670
KEGG:R01220
http://purl.org/obo/owl/KEGG#KEGG_R01220
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200159
http://purl.org/obo/owl/IMR#IMR_0200159
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200517
http://purl.org/obo/owl/IMR#IMR_0200517
Acetyl-CoA + alkane-alpha,omega-diamine = CoA + N-acetyldiamine( EC:2.3.1.57 )
event
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
EC:2.3.1.57
http://purl.org/obo/owl/EC#EC_2.3.1.57
KEGG:C02297
http://purl.org/obo/owl/KEGG#KEGG_C02297
IMR:0200414
http://purl.org/obo/owl/IMR#IMR_0200414
KEGG:R03910
http://purl.org/obo/owl/KEGG#KEGG_R03910
KEGG:C03687
http://purl.org/obo/owl/KEGG#KEGG_C03687
Acetyl-CoA + 2-arylethylamine = CoA + N-acetyl-2-arylethylamine( EC:2.3.1.87 )
event
KEGG:R03760
http://purl.org/obo/owl/KEGG#KEGG_R03760
KEGG:C15535
http://purl.org/obo/owl/KEGG#KEGG_C15535
KEGG:C15534
http://purl.org/obo/owl/KEGG#KEGG_C15534
EC:2.3.1.87
http://purl.org/obo/owl/EC#EC_2.3.1.87
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
IMR:0200414
http://purl.org/obo/owl/IMR#IMR_0200414
UDP + H2O => UMP + Orthophosphate( EC:3.6.1.6 )
event
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200206
http://purl.org/obo/owl/IMR#IMR_0200206
EC:3.6.1.6
http://purl.org/obo/owl/EC#EC_3.6.1.6
KEGG:map00240
http://purl.org/obo/owl/KEGG#KEGG_map00240
KEGG:R00155
http://purl.org/obo/owl/KEGG#KEGG_R00155
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200409
http://purl.org/obo/owl/IMR#IMR_0200409
GDP + H2O => GMP + Orthophosphate( EC:3.6.1.6 )
event
KEGG:R00328
http://purl.org/obo/owl/KEGG#KEGG_R00328
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200292
http://purl.org/obo/owl/IMR#IMR_0200292
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
EC:3.6.1.6
http://purl.org/obo/owl/EC#EC_3.6.1.6
IDP + H2O => IMP + Orthophosphate( EC:3.6.1.5 )
event
EC:3.6.1.6
http://purl.org/obo/owl/EC#EC_3.6.1.6
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
KEGG:R00961
http://purl.org/obo/owl/KEGG#KEGG_R00961
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200511
http://purl.org/obo/owl/IMR#IMR_0200511
IMR:0200221
http://purl.org/obo/owl/IMR#IMR_0200221
L-Cysteic acid => Taurine + CO2( EC:4.1.1.29 )
event
KEGG:map00430
http://purl.org/obo/owl/KEGG#KEGG_map00430
KEGG:R01682
http://purl.org/obo/owl/KEGG#KEGG_R01682
IMR:0100120
http://purl.org/obo/owl/IMR#IMR_0100120
EC:4.1.1.29
http://purl.org/obo/owl/EC#EC_4.1.1.29
IMR:0200417
http://purl.org/obo/owl/IMR#IMR_0200417
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
L-Cysteine-sulfinic acid => Hypotaurine + CO2( EC:4.1.1.15 )
event
IMR:0200305
http://purl.org/obo/owl/IMR#IMR_0200305
EC:4.1.1.15
http://purl.org/obo/owl/EC#EC_4.1.1.15
IMR:0200402
http://purl.org/obo/owl/IMR#IMR_0200402
IMR:0200324
http://purl.org/obo/owl/IMR#IMR_0200324
KEGG:R02466
http://purl.org/obo/owl/KEGG#KEGG_R02466
KEGG:map00430
http://purl.org/obo/owl/KEGG#KEGG_map00430
NAD+ + 4-Amino-butyraldehyde + H2O => NADH + 4-Amino-butanoic acid + H+( EC:1.2.1.3 )
NAD+ + 4-Amino-butyraldehyde + H2O => NADH + 4-Amino-butanoic acid( EC:1.2.1.3 )
event
KEGG:map00410
http://purl.org/obo/owl/KEGG#KEGG_map00410
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
KEGG:R02549
http://purl.org/obo/owl/KEGG#KEGG_R02549
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200521
http://purl.org/obo/owl/IMR#IMR_0200521
IMR:0200142
http://purl.org/obo/owl/IMR#IMR_0200142
IMR:0200248
http://purl.org/obo/owl/IMR#IMR_0200248
IMR:0100117
http://purl.org/obo/owl/IMR#IMR_0100117
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.2.1.3
http://purl.org/obo/owl/EC#EC_1.2.1.3
2-Methyl-propanoyl-CoA + Acceptor = 2-Methylprop-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.2 )
event
KEGG:R02661
http://purl.org/obo/owl/KEGG#KEGG_R02661
IMR:0200164
http://purl.org/obo/owl/IMR#IMR_0200164
EC:1.3.99.2
http://purl.org/obo/owl/EC#EC_1.3.99.2
KEGG:map00280
http://purl.org/obo/owl/KEGG#KEGG_map00280
IMR:0200300
http://purl.org/obo/owl/IMR#IMR_0200300
IMR:0200224
http://purl.org/obo/owl/IMR#IMR_0200224
IMR:0200174
http://purl.org/obo/owl/IMR#IMR_0200174
AMP + Pyrophosphate = Adenine + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.8 )
AMP + Pyrophosphate = Adenine + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.8 )
event
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200179
http://purl.org/obo/owl/IMR#IMR_0200179
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200350
http://purl.org/obo/owl/IMR#IMR_0200350
KEGG:R00190
http://purl.org/obo/owl/KEGG#KEGG_R00190
EC:2.4.2.8
http://purl.org/obo/owl/EC#EC_2.4.2.8
GMP + Pyrophosphate = Guanine + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.8 )
GMP + Pyrophosphate = Guanine + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.8 )
event
KEGG:R01229
http://purl.org/obo/owl/KEGG#KEGG_R01229
IMR:0200292
http://purl.org/obo/owl/IMR#IMR_0200292
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0200319
http://purl.org/obo/owl/IMR#IMR_0200319
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
IMR:0200179
http://purl.org/obo/owl/IMR#IMR_0200179
EC:2.4.2.8
http://purl.org/obo/owl/EC#EC_2.4.2.8
2-Oxo-glutaric acid + L-Phenylalanine = L-Glutamic acid + Phenyl-pyruvic acid( EC:2.6.1.1 )
event
EC:2.6.1.1
http://purl.org/obo/owl/EC#EC_2.6.1.1
KEGG:map00360
http://purl.org/obo/owl/KEGG#KEGG_map00360
KEGG:R00694
http://purl.org/obo/owl/KEGG#KEGG_R00694
KEGG:map00400
http://purl.org/obo/owl/KEGG#KEGG_map00400
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0200274
http://purl.org/obo/owl/IMR#IMR_0200274
IMR:0200380
http://purl.org/obo/owl/IMR#IMR_0200380
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
Citric acid = Isocitric acid( EC:4.2.1.3 )
two-step reaction
event
KEGG:R01324
http://purl.org/obo/owl/KEGG#KEGG_R01324
IMR:0200473
http://purl.org/obo/owl/IMR#IMR_0200473
IMR:0200023
http://purl.org/obo/owl/IMR#IMR_0200023
EC:4.2.1.3
http://purl.org/obo/owl/EC#EC_4.2.1.3
ATP + ADP = ADP + ATP( EC:2.7.4.6 )
event
KEGG:R00124
http://purl.org/obo/owl/KEGG#KEGG_R00124
EC:2.7.4.6
http://purl.org/obo/owl/EC#EC_2.7.4.6
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
KEGG:map00230
http://purl.org/obo/owl/KEGG#KEGG_map00230
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
FGF8 signaling pathway(Xenopus)
event
OBSOLETE: remap to 'FGF8 signaling pathway' IEV:0003405.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
FGF8 signaling pathway(Mouse)
event
OBSOLETE: remap to 'FGF8 signaling pathway' IEV:0003405.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Binding of FGF8 and FGFR1 in extracellular
event
IMR:0002055
http://purl.org/obo/owl/IMR#IMR_0002055
IMR:0100558
http://purl.org/obo/owl/IMR#IMR_0100558
FGF8:FGFR1 dimerization in plasma membrane
event
IMR:0002055
http://purl.org/obo/owl/IMR#IMR_0002055
IMR:0100558
http://purl.org/obo/owl/IMR#IMR_0100558
Autophosphorylation of FGFR1 in plasma membrane
event
IMR:0002055
http://purl.org/obo/owl/IMR#IMR_0002055
Binding of FGFR1_p and FRS2 in cytosol
event
IMR:0001836
http://purl.org/obo/owl/IMR#IMR_0001836
IMR:0002055
http://purl.org/obo/owl/IMR#IMR_0002055
Phosphorylation of FRS2 by FGFR1_p in cytosol
event
IMR:0001836
http://purl.org/obo/owl/IMR#IMR_0001836
IMR:0002055
http://purl.org/obo/owl/IMR#IMR_0002055
Phosphorylation of ETS1/2 by ERK1/2_p in inner space of nucleus
event
IMR:0000400
http://purl.org/obo/owl/IMR#IMR_0000400
IMR:0000399
http://purl.org/obo/owl/IMR#IMR_0000399
IMR:0000227
http://purl.org/obo/owl/IMR#IMR_0000227
Binding of ETS1/2_p and responsive element in inner space of nucleus
event
IGS:0000028
http://purl.org/obo/owl/IGS#IGS_0000028
IMR:0000399
http://purl.org/obo/owl/IMR#IMR_0000399
IMR:0000400
http://purl.org/obo/owl/IMR#IMR_0000400
Transcription of ETS target gene in nucleus
event
IMR:0000397
http://purl.org/obo/owl/IMR#IMR_0000397
Negative feedback regulation of FGF8 signaling by Sprouty2
event
IMR:0002082
http://purl.org/obo/owl/IMR#IMR_0002082
Binding of Grb2 and Sprouty2 in cytosol
event
IMR:0000340
http://purl.org/obo/owl/IMR#IMR_0000340
IMR:0002082
http://purl.org/obo/owl/IMR#IMR_0002082
Phosphorylation of Sprouty2 by FGFR1 in cytosol
event
IMR:0002055
http://purl.org/obo/owl/IMR#IMR_0002055
IMR:0002082
http://purl.org/obo/owl/IMR#IMR_0002082
Gene expression of Sprouty2 by ETS1/2
event
IMR:0000400
http://purl.org/obo/owl/IMR#IMR_0000400
IMR:0000399
http://purl.org/obo/owl/IMR#IMR_0000399
IMR:0002082
http://purl.org/obo/owl/IMR#IMR_0002082
Translation of Sprouty2 in cytosol
event
IMR:0002082
http://purl.org/obo/owl/IMR#IMR_0002082
Nuclear export of mRNA (Sprouty2)
event
IMR:0002082
http://purl.org/obo/owl/IMR#IMR_0002082
Transcription of Sprouty2 gene in nucleus
event
IMR:0002082
http://purl.org/obo/owl/IMR#IMR_0002082
Negative feedback regulation of FGF8 signaling by Sef
event
IMR:0002086
http://purl.org/obo/owl/IMR#IMR_0002086
Binding of FGFR1 and Sef in cytosol
event
IMR:0002086
http://purl.org/obo/owl/IMR#IMR_0002086
IMR:0002055
http://purl.org/obo/owl/IMR#IMR_0002055
Gene expression of Sef by ETS1/2
event
IMR:0002086
http://purl.org/obo/owl/IMR#IMR_0002086
IMR:0000400
http://purl.org/obo/owl/IMR#IMR_0000400
IMR:0000399
http://purl.org/obo/owl/IMR#IMR_0000399
Transcription of Sef gene in nucleus
event
IMR:0002086
http://purl.org/obo/owl/IMR#IMR_0002086
Nuclear export of mRNA (Sef)
event
IMR:0002086
http://purl.org/obo/owl/IMR#IMR_0002086
Translation of Sef in cytosol
event
IMR:0002086
http://purl.org/obo/owl/IMR#IMR_0002086
Negative feedback regulation of FGF8 signaling by Mkp3
event
IMR:0100235
http://purl.org/obo/owl/IMR#IMR_0100235
Binding of ERK1/2_p and Mkp3 in cytosol
event
IMR:0000227
http://purl.org/obo/owl/IMR#IMR_0000227
IMR:0100235
http://purl.org/obo/owl/IMR#IMR_0100235
Gene expression of Mkp3 by ETS1/2
event
PubMed:18321244
http://purl.org/obo/owl/PubMed#PubMed_18321244
IMR:0100235
http://purl.org/obo/owl/IMR#IMR_0100235
IMR:0000400
http://purl.org/obo/owl/IMR#IMR_0000400
IMR:0000399
http://purl.org/obo/owl/IMR#IMR_0000399
Transcription of Mkp3 gene in nucleus
event
IMR:0100235
http://purl.org/obo/owl/IMR#IMR_0100235
Nuclear export of mRNA (Mkp3)
event
IMR:0100235
http://purl.org/obo/owl/IMR#IMR_0100235
Translation of Mkp3 in cytosol
event
IMR:0100235
http://purl.org/obo/owl/IMR#IMR_0100235
Negative feedback regulation of FGF8 signaling by Sprouty1
event
IMR:0002081
http://purl.org/obo/owl/IMR#IMR_0002081
Binding of Grb2 and Sprouty1_p in cytosol
event
IMR:0002081
http://purl.org/obo/owl/IMR#IMR_0002081
IMR:0000340
http://purl.org/obo/owl/IMR#IMR_0000340
Phosphorylation of Sprouty1 by FGFR1 in cytosol
event
IMR:0002081
http://purl.org/obo/owl/IMR#IMR_0002081
IMR:0002055
http://purl.org/obo/owl/IMR#IMR_0002055
Gene expression of Sprouty1 by ETS1/2
event
IMR:0000399
http://purl.org/obo/owl/IMR#IMR_0000399
IMR:0000400
http://purl.org/obo/owl/IMR#IMR_0000400
IMR:0002081
http://purl.org/obo/owl/IMR#IMR_0002081
Transcription of Sprouty1 gene in nucleus
event
IMR:0002081
http://purl.org/obo/owl/IMR#IMR_0002081
Nuclear export of mRNA (Sprouty1)
event
IMR:0002081
http://purl.org/obo/owl/IMR#IMR_0002081
Translation of Sprouty1 in cytosol
event
IMR:0002081
http://purl.org/obo/owl/IMR#IMR_0002081
Expression of antimicrobial peptide by DIF [Drosophila]
event
OBSOLETE: remap to 'Expression of antimicrobial peptide by DIF' IEV:0003511.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Expression of cecropin by DIF [Drosophila]
event
OBSOLETE: remap to 'Expression of cecropin by DIF' IEV:0003513.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Expression of drosomycin by DIF [Drosophila]
event
OBSOLETE: remap to 'Expression of drosomycin by DIF' IEV:0003515.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Expression of diptericin by DIF [Drosophila]
event
OBSOLETE: remap to 'Expression of diptericin by DIF' IEV:0003514.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Expression of antimicrobial peptide by DIF:Dorsal [Drosophila]
event
OBSOLETE: remap to 'Expression of antimicrobial peptide by DIF:Dorsal' IEV:0003525.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Expression of antimicrobial peptide by Dorsal [Drosophila]
event
OBSOLETE: remap to 'Expression of antimicrobial peptide by Dorsal' IEV:0003533.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Expression of drosomycin by Dorsal [Drosophila]
event
OBSOLETE: remap to 'Expression of drosomycin by Dorsal' IEV:0003535.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Transcription of drosomycin by Dorsal [Drosophila]
event
OBSOLETE: remap to 'Transcription of drosomycin by Dorsal' IEV:0003536.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Transcription of cecropin by DIF [Drosophila]
event
OBSOLETE: remap to 'Transcription of cecropin by DIF' IEV:0003516.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Transcription of drosomycin by DIF [Drosophila]
event
OBSOLETE: remap to 'Transcription of drosomycin by DIF' IEV:0003519.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Transcription of diptericin by DIF [Drosophila]
event
OBSOLETE: remap to 'Transcription of diptericin by DIF' IEV:0003520.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Autophosphorylation of JAK1 and JAK2 in cytosol
event
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
Autophosphorylation of JAK1 and TYK2 in cytosol
event
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0100322
http://purl.org/obo/owl/IMR#IMR_0100322
Autophosphorylation of JAK2 and TYK2 in cytosol
event
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
IMR:0100322
http://purl.org/obo/owl/IMR#IMR_0100322
Autophosphorylation of JAK1 and JAK3 in cytosol
event
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0100321
http://purl.org/obo/owl/IMR#IMR_0100321
Phosphorylation of ATF-2 by p38 in inner space of nucleus
event
IMR:0000226
http://purl.org/obo/owl/IMR#IMR_0000226
IMR:0000827
http://purl.org/obo/owl/IMR#IMR_0000827
Phosphorylation of MKK3/6 by TAK1 in cytosol
event
IMR:0000232
http://purl.org/obo/owl/IMR#IMR_0000232
IMR:0000263
http://purl.org/obo/owl/IMR#IMR_0000263
Phosphorylation of MKK4 by TAK1 in cytosol
event
IMR:0000232
http://purl.org/obo/owl/IMR#IMR_0000232
IMR:0100454
http://purl.org/obo/owl/IMR#IMR_0100454
Cell division
event
GO:0051301
http://purl.org/obo/owl/GO#GO_0051301
The processes resulting in the physical partitioning and separation of a cell into daughter cells.
GO:0051301
http://purl.org/obo/owl/GO#GO_0051301
Phosphorylation of TAB2 and TAK1 in cytosol
event
IMR:0000232
http://purl.org/obo/owl/IMR#IMR_0000232
IMR:0000893
http://purl.org/obo/owl/IMR#IMR_0000893
Dissociation of TRAF6:TAK1:TAB1:TAB2 and IRAK in cytosol
event
IMR:0000232
http://purl.org/obo/owl/IMR#IMR_0000232
Dissociation of IRAK from TRAF6:TAK1:TAB1:TAB2:IRAK in cytosol
IMR:0100488
http://purl.org/obo/owl/IMR#IMR_0100488
IMR:0100427
http://purl.org/obo/owl/IMR#IMR_0100427
IMR:0000441
http://purl.org/obo/owl/IMR#IMR_0000441
IMR:0000893
http://purl.org/obo/owl/IMR#IMR_0000893
Processing of MEKK1 in cytosol
event
IMR:0100222
http://purl.org/obo/owl/IMR#IMR_0100222
Gene expression by AP-1
event
IMR:0000414
http://purl.org/obo/owl/IMR#IMR_0000414
Transcription by AP-1 in nucleus
event
IMR:0000414
http://purl.org/obo/owl/IMR#IMR_0000414
Phosphorylation of MKK by TAK1 in cytosol
event
IMR:0000259
http://purl.org/obo/owl/IMR#IMR_0000259
IMR:0000232
http://purl.org/obo/owl/IMR#IMR_0000232
Phosphorylation of MKK by MEKK1 in cytosol
event
IMR:0100222
http://purl.org/obo/owl/IMR#IMR_0100222
IMR:0000259
http://purl.org/obo/owl/IMR#IMR_0000259
Elongation
event
PubMed:14755292
http://purl.org/obo/owl/PubMed#PubMed_14755292
GO:0006271
http://purl.org/obo/owl/GO#GO_0006271
DNA strand elongation
MI:0701
http://purl.org/obo/owl/MI#MI_0701
MI:0701
http://purl.org/obo/owl/MI#MI_0701
EC:2.7.7.7
http://purl.org/obo/owl/EC#EC_2.7.7.7
The process by which a DNA strand is synthesized from template DNA by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand.
MI:0701
http://purl.org/obo/owl/MI#MI_0701
Phosphotransfer
event
EC:2.7.1.61
http://purl.org/obo/owl/EC#EC_2.7.1.61
EC:2.7.1.42
http://purl.org/obo/owl/EC#EC_2.7.1.42
EC:2.7.1.62
http://purl.org/obo/owl/EC#EC_2.7.1.62
EC:2.7.1.63
http://purl.org/obo/owl/EC#EC_2.7.1.63
EC:2.7.1.69
http://purl.org/obo/owl/EC#EC_2.7.1.69
PubMed:16712436
http://purl.org/obo/owl/PubMed#PubMed_16712436
MI:0844
http://purl.org/obo/owl/MI#MI_0844
PubMed:14755292
http://purl.org/obo/owl/PubMed#PubMed_14755292
Reaction where a phosphate is transferred between two proteins of a phosphorelay system.
MI:0844
http://purl.org/obo/owl/MI#MI_0844
synthetic interaction
event
PubMed:15833125
http://purl.org/obo/owl/PubMed#PubMed_15833125
synthetic
MI:0794
http://purl.org/obo/owl/MI#MI_0794
The phenotype resulting from genetic perturbation A and the phenotype resulting from genetic perturbation B have no effect on the WT background, but the combined genetic perturbation of A and B has a phenotypic effect.
MI:0794
http://purl.org/obo/owl/MI#MI_0794
asynthetic interaction
event
MI:0795
http://purl.org/obo/owl/MI#MI_0795
PubMed:15833125
http://purl.org/obo/owl/PubMed#PubMed_15833125
The phenotype resulting from genetic perturbation of A alone, B alone and AB combined have the same effect on the WT background.
MI:0795
http://purl.org/obo/owl/MI#MI_0795
asynthetic
suppressive interaction
event
The phenotype resulting from genetic perturbation of A has an effect on WT, but that effect is abolished by adding the suppressor B, which itself shows no single-mutant effect (for example, WT = B = AB < A).
MI:0796
http://purl.org/obo/owl/MI#MI_0796
PubMed:15833125
http://purl.org/obo/owl/PubMed#PubMed_15833125
MI:0796
http://purl.org/obo/owl/MI#MI_0796
epistatic interaction
event
epistatic
The phenotype resulting from genetic perturbation of A and B have different effects (in terms of direction or magnitude) on the wild-type background and the double mutant has the same phenotype as either A or B (for example, A < WT < B = AB).
MI:0797
http://purl.org/obo/owl/MI#MI_0797
MI:0797
http://purl.org/obo/owl/MI#MI_0797
PubMed:15833125
http://purl.org/obo/owl/PubMed#PubMed_15833125
conditional interaction
event
conditional
The phenotype resulting from genetic perturbation of A has an effect only in the B background, or the B mutant has an effect only in the A background.
MI:0798
http://purl.org/obo/owl/MI#MI_0798
MI:0798
http://purl.org/obo/owl/MI#MI_0798
PubMed:15833125
http://purl.org/obo/owl/PubMed#PubMed_15833125
enhancement interaction
event
PubMed:15833125
http://purl.org/obo/owl/PubMed#PubMed_15833125
enhancement
The A genetic perturbation enhances the phenotype of the B perturbation, or vice versa (e.g. WT = A < B < AB or WT = B < A < AB). This could be conditional or additive by the above scheme.
MI:0802
http://purl.org/obo/owl/MI#MI_0802
MI:0802
http://purl.org/obo/owl/MI#MI_0802
additive interaction
event
PubMed:15833125
http://purl.org/obo/owl/PubMed#PubMed_15833125
MI:0799
http://purl.org/obo/owl/MI#MI_0799
Single-mutant phenotype effects combine to give a double-mutant effect different from the wild type and different from single mutant effect. For instance WT < A= B < AB, B < WT = AB < A, WT < A < B < AB, B < WT < AB < A, and all additional inequalities obtained by interchanging A and B, or reversing the effect of both A and B.
MI:0799
http://purl.org/obo/owl/MI#MI_0799
additive
single nonmonotonic interaction
event
single nonmonotonic
The phenotype resulting from genetic perturbation of B shows opposing effects in the WT and A backgrounds (for example, B > WT and AB< A); or, A shows opposing effects in the WT and B backgrounds, but not both.
MI:0800
http://purl.org/obo/owl/MI#MI_0800
MI:0800
http://purl.org/obo/owl/MI#MI_0800
PubMed:15833125
http://purl.org/obo/owl/PubMed#PubMed_15833125
double nonmonotonic interaction
event
MI:0801
http://purl.org/obo/owl/MI#MI_0801
PubMed:15833125
http://purl.org/obo/owl/PubMed#PubMed_15833125
The phenotype resulting from genetic perturbation of both A and B show opposing effects in the WT background and the background with the other mutant gene.
MI:0801
http://purl.org/obo/owl/MI#MI_0801
double nonmonotonic
Binding of Fas and DAXX in cytosol
event
IMR:0010252
http://purl.org/obo/owl/IMR#IMR_0010252
IMR:0002642
http://purl.org/obo/owl/IMR#IMR_0002642
Phosphorylation of transcriptional regulator by JNK_p in inner space of nucleus
event
IMR:0000369
http://purl.org/obo/owl/IMR#IMR_0000369
IMR:0000225
http://purl.org/obo/owl/IMR#IMR_0000225
Phosphorylation of Itch by JNK_p in inner space of nucleus
event
IMR:0000225
http://purl.org/obo/owl/IMR#IMR_0000225
IMR:0001945
http://purl.org/obo/owl/IMR#IMR_0001945
FGFR1 signaling pathway
event
FGF8 signaling pathway
FGF8 signaling pathway(Xenopus)
FGF8 signaling pathway(Mouse)
Activation of ASK1 by DAXX in cytosol
event
IMR:0002642
http://purl.org/obo/owl/IMR#IMR_0002642
IMR:0100218
http://purl.org/obo/owl/IMR#IMR_0100218
Phosphorylation of 14-3-3 by JNK_p in cytosol
event
IMR:0000456
http://purl.org/obo/owl/IMR#IMR_0000456
IMR:0000225
http://purl.org/obo/owl/IMR#IMR_0000225
Dissociation of 14-3-3_p and Bax in cytosol
event
IMR:0000453
http://purl.org/obo/owl/IMR#IMR_0000453
IMR:0000456
http://purl.org/obo/owl/IMR#IMR_0000456
Cleavage in extracellular
event
Cleavage of Spaetzle by serine protease [Drosophila]
event
OBSOLETE: remap to 'Cleavage of Spaetzle by serine protease' IEV:0003502.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Cleavage of Spaetzle by PSH [Drosophila]
event
OBSOLETE: remap to 'Cleavage of Spaetzle by PSH' IEV:0003505.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
Caspase3 activation signaling (not through mitochondria)
event
Caspase3 activation signaling (through mitochondria)
event
Caspase3 homodimer formation in cytosol
event
IMR:0100296
http://purl.org/obo/owl/IMR#IMR_0100296
Hydrolysis of Procaspase3 by caspase8 in cytosol
event
IMR:0100296
http://purl.org/obo/owl/IMR#IMR_0100296
IMR:0100300
http://purl.org/obo/owl/IMR#IMR_0100300
Ubiquitination of c-FLIP by Itch_p in cytosol
event
IMR:0002641
http://purl.org/obo/owl/IMR#IMR_0002641
IMR:0001945
http://purl.org/obo/owl/IMR#IMR_0001945
Dimerization of TRADD:TRAF2:RIP complex in cytosol
event
IMR:0000269
http://purl.org/obo/owl/IMR#IMR_0000269
IMR:0100423
http://purl.org/obo/owl/IMR#IMR_0100423
IMR:0100464
http://purl.org/obo/owl/IMR#IMR_0100464
Proteasome degradation of c-FLIP in cytosol
event
IMR:0002641
http://purl.org/obo/owl/IMR#IMR_0002641
Phosphorylation of IKK complex by RIP in cytosol
event
IMR:0000243
http://purl.org/obo/owl/IMR#IMR_0000243
IMR:0000269
http://purl.org/obo/owl/IMR#IMR_0000269
Gene expression of c-FLIP by NF-kappaB
event
IMR:0000382
http://purl.org/obo/owl/IMR#IMR_0000382
IMR:0002641
http://purl.org/obo/owl/IMR#IMR_0002641
Transcription of c-FLIP gene in nucleus
event
IMR:0002641
http://purl.org/obo/owl/IMR#IMR_0002641
Nuclear export of mRNA (c-FLIP)
event
IMR:0002641
http://purl.org/obo/owl/IMR#IMR_0002641
Translation of c-FLIP in cytosol
event
IMR:0002641
http://purl.org/obo/owl/IMR#IMR_0002641
Binding of DAG and PKC delta and active conformational change of PKC delta in cytosol
event
IMR:0100027
http://purl.org/obo/owl/IMR#IMR_0100027
IMR:0001148
http://purl.org/obo/owl/IMR#IMR_0001148
Phosphorylation of Raf by PKC delta in cytosol
event
IMR:0001148
http://purl.org/obo/owl/IMR#IMR_0001148
IMR:0000231
http://purl.org/obo/owl/IMR#IMR_0000231
Binding of DAG and nPKC and active conformational change of nPKC in cytosol
event
IMR:0100027
http://purl.org/obo/owl/IMR#IMR_0100027
IMR:0000246
http://purl.org/obo/owl/IMR#IMR_0000246
Phosphorylation of Raf1 by PKC in cytosol
event
IMR:0000245
http://purl.org/obo/owl/IMR#IMR_0000245
IMR:0100355
http://purl.org/obo/owl/IMR#IMR_0100355
Binding of Epac1 and cAMP in cytosol
event
IMR:0001968
http://purl.org/obo/owl/IMR#IMR_0001968
IMR:0100024
http://purl.org/obo/owl/IMR#IMR_0100024
Binding of Epac1 and Rap1 in cytosol
event
IMR:0001968
http://purl.org/obo/owl/IMR#IMR_0001968
IMR:0001504
http://purl.org/obo/owl/IMR#IMR_0001504
Binding of Adenosine and Adenosine A2A receptor in extracellular
event
IMR:0002671
http://purl.org/obo/owl/IMR#IMR_0002671
IMR:0100126
http://purl.org/obo/owl/IMR#IMR_0100126
Binding of Adenosine A2A receptor and G alpha s in cytosol
event
IMR:0002671
http://purl.org/obo/owl/IMR#IMR_0002671
IMR:0100366
http://purl.org/obo/owl/IMR#IMR_0100366
Dissociation of Adenosine A2A receptor, G alpha s-GTP and G beta:G gamma in cytosol
event
IMR:0100366
http://purl.org/obo/owl/IMR#IMR_0100366
IMR:0100018
http://purl.org/obo/owl/IMR#IMR_0100018
IMR:0002671
http://purl.org/obo/owl/IMR#IMR_0002671
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Phosphorylation of STAT1 by JAK2_p in cytosol
event
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
Binding of EPO and EPO receptor complex and conformational change of receptors in plasma membrane
event
IMR:0000016
http://purl.org/obo/owl/IMR#IMR_0000016
IMR:0000127
http://purl.org/obo/owl/IMR#IMR_0000127
Phosphorylation of EPO receptor by JAK2 in cytosol
event
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
IMR:0000127
http://purl.org/obo/owl/IMR#IMR_0000127
Binding of EPO receptor and STAT5 in cytosol
event
IMR:0000127
http://purl.org/obo/owl/IMR#IMR_0000127
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
Dissociation of EPO receptor and STAT5 in cytosol
event
IMR:0000127
http://purl.org/obo/owl/IMR#IMR_0000127
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
Binding of EPO receptor and STAT3 in cytosol
event
IMR:0000127
http://purl.org/obo/owl/IMR#IMR_0000127
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
Dissociation of EPO receptor and STAT3 in cytosol
event
IMR:0000127
http://purl.org/obo/owl/IMR#IMR_0000127
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
Binding of EPO receptor and PI3K in cytosol
event
IMR:0000265
http://purl.org/obo/owl/IMR#IMR_0000265
IMR:0000127
http://purl.org/obo/owl/IMR#IMR_0000127
Phosphorylation of PI3K by JAK2_p in cytosol
event
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
IMR:0000265
http://purl.org/obo/owl/IMR#IMR_0000265
Phosphorylation of CARMA1 by PKC theta in cytosol
event
IMR:0002655
http://purl.org/obo/owl/IMR#IMR_0002655
IMR:0100484
http://purl.org/obo/owl/IMR#IMR_0100484
Binding of CARMA1 and BCL10 in cytosol
event
IMR:0002655
http://purl.org/obo/owl/IMR#IMR_0002655
IMR:0002658
http://purl.org/obo/owl/IMR#IMR_0002658
IKK activation signaling (through PKC beta and CARMA1:BCL10:MALT1)
event
Phosphorylation of CARMA1 by PKC beta in cytosol
event
IMR:0002655
http://purl.org/obo/owl/IMR#IMR_0002655
IMR:0001146
http://purl.org/obo/owl/IMR#IMR_0001146
Demethylation
event
The cleavage of a methyl group from a polypeptide. Methylation is generally an irreversible reaction except in mamalian.
MI:0871
http://purl.org/obo/owl/MI#MI_0871
MI:0871
http://purl.org/obo/owl/MI#MI_0871
GO:0006482
http://purl.org/obo/owl/GO#GO_0006482
nucleoside triphosphatase reaction
event
GO:0017111
http://purl.org/obo/owl/GO#GO_0017111
MI:0881
http://purl.org/obo/owl/MI#MI_0881
Catalysis of the hydrolisis of a nucleoside triphosphate into a nucleoside diphosphate plus phosphate.
MI:0881
http://purl.org/obo/owl/MI#MI_0881
atpase reaction
event
GO:0016887
http://purl.org/obo/owl/GO#GO_0016887
Catalysis of the hydrolisis of ATP+ H2O = ADP + phosphate.
MI:0882
http://purl.org/obo/owl/MI#MI_0882
MI:0882
http://purl.org/obo/owl/MI#MI_0882
gtpase reaction
event
GO:0003924
http://purl.org/obo/owl/GO#GO_0003924
Catalysis of the hydrolisis of GTP+ H2O = GDP + phosphate.
MI:0883
http://purl.org/obo/owl/MI#MI_0883
MI:0883
http://purl.org/obo/owl/MI#MI_0883
Binding of IRS_p and Grb2 in cytosol
event
REACT:646.3
http://purl.org/obo/owl/REACT#REACT_646.3
IMR:0000351
http://purl.org/obo/owl/IMR#IMR_0000351
IMR:0000340
http://purl.org/obo/owl/IMR#IMR_0000340
Translocation of GLUT4 from cytosol to plasma membrane
event
IMR:0010283
http://purl.org/obo/owl/IMR#IMR_0010283
Binding of GHR_p and SOCS-2 in cytosol
event
IMR:0100735
http://purl.org/obo/owl/IMR#IMR_0100735
IMR:0100838
http://purl.org/obo/owl/IMR#IMR_0100838
Binding of JAK2_p and SOCS-1 in cytosol
event
IMR:0100837
http://purl.org/obo/owl/IMR#IMR_0100837
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
Binding of GHR_p and SOCS-3 in cytosol
event
IMR:0100839
http://purl.org/obo/owl/IMR#IMR_0100839
IMR:0100735
http://purl.org/obo/owl/IMR#IMR_0100735
Endoderm induction Wnt signaling pathway
event
C. elegans endoderm induction Wnt signaling pathway
PubMed:12210516
http://purl.org/obo/owl/PubMed#PubMed_12210516
IMD signaling pathway
event
Drosophila IMD pathway [Drosophila]
Binding of PGRP-LC and LPS in extracellular
event
IMR:0001787
http://purl.org/obo/owl/IMR#IMR_0001787
Binding of PGRP-LC and LPS [Drosophila]
IMR:0001655
http://purl.org/obo/owl/IMR#IMR_0001655
Binding of FADD and caspase8 in cytosol
event
IMR:0100300
http://purl.org/obo/owl/IMR#IMR_0100300
IMR:0100463
http://purl.org/obo/owl/IMR#IMR_0100463
Binding of dFADD and Dredd [Drosophila]
Activation of TAK1 by IMD in cytosol
event
Activation of TAK1 by IMD [Drosophila]
IMR:0000232
http://purl.org/obo/owl/IMR#IMR_0000232
IMR:0001808
http://purl.org/obo/owl/IMR#IMR_0001808
Binding of DIF:Relish and NF-kappaB binding sequence in inner space of nucleus
event
IGS:0000010
http://purl.org/obo/owl/IGS#IGS_0000010
Binding of DIF:Relish and NF-kappaB binding sequence [Drosophila]
IMR:0001814
http://purl.org/obo/owl/IMR#IMR_0001814
IMR:0001806
http://purl.org/obo/owl/IMR#IMR_0001806
Binding of PGRP-LC and IMD in cytosol
event
IMR:0001808
http://purl.org/obo/owl/IMR#IMR_0001808
IMR:0001787
http://purl.org/obo/owl/IMR#IMR_0001787
Binding of PGRP-LC and IMD [Drosophila]
Binding of Dnr-1 and caspase8 in cytosol
event
IMR:0001816
http://purl.org/obo/owl/IMR#IMR_0001816
IMR:0100300
http://purl.org/obo/owl/IMR#IMR_0100300
Binding of Dnr-1 and Dredd [Drosophila]
Binding of IMD and FADD in cytosol
event
IMR:0001808
http://purl.org/obo/owl/IMR#IMR_0001808
IMR:0100463
http://purl.org/obo/owl/IMR#IMR_0100463
Binding of IMD and dFADD [Drosophila]
Expression of antimicrobial peptide by Relish
event
Expression of antimicrobial peptide by Relish [Drosophila]
IMR:0001814
http://purl.org/obo/owl/IMR#IMR_0001814
IMR:0001815
http://purl.org/obo/owl/IMR#IMR_0001815
Binding of PGRP-LC and PGN in extracellular
event
IMR:0001787
http://purl.org/obo/owl/IMR#IMR_0001787
Binding of PGRP-LC and PGN [Drosophila]
IMR:0001699
http://purl.org/obo/owl/IMR#IMR_0001699
Binding of PGRP-LE and PGN in extracellular
event
Binding of PGRP-LE and PGN [Drosophila]
IMR:0001699
http://purl.org/obo/owl/IMR#IMR_0001699
IMR:0001788
http://purl.org/obo/owl/IMR#IMR_0001788
Cleavage and activation of Relish by caspase8 in cytosol
event
Cleavage and activation of Relish by Dredd [Drosophila]
IMR:0100300
http://purl.org/obo/owl/IMR#IMR_0100300
IMR:0001814
http://purl.org/obo/owl/IMR#IMR_0001814
Binding of Relish and NF-kappaB binding sequence in inner space of nucleus
event
IGS:0000010
http://purl.org/obo/owl/IGS#IGS_0000010
IMR:0001814
http://purl.org/obo/owl/IMR#IMR_0001814
Binding of Relish and NF-kappaB binding sequence [Drosophila]
Phosphorylation of Relish by IKK in cytosol
event
Phosphorylation of Relish by IKK [Drosophila]
IMR:0000243
http://purl.org/obo/owl/IMR#IMR_0000243
IMR:0001814
http://purl.org/obo/owl/IMR#IMR_0001814
Nuclear import of Relish
event
Nuclear import of Relish [Drosophila]
IMR:0001814
http://purl.org/obo/owl/IMR#IMR_0001814
Expression of diptericin by Relish
event
IMR:0001817
http://purl.org/obo/owl/IMR#IMR_0001817
IMR:0001814
http://purl.org/obo/owl/IMR#IMR_0001814
Expression of diptericin by Relish [Drosophila]
Expression of drosocin by Relish
event
Expression of drosocin by Relish [Drosophila]
IMR:0001814
http://purl.org/obo/owl/IMR#IMR_0001814
IMR:0001827
http://purl.org/obo/owl/IMR#IMR_0001827
Expression of attacin by Relish
event
IMR:0001814
http://purl.org/obo/owl/IMR#IMR_0001814
IMR:0001823
http://purl.org/obo/owl/IMR#IMR_0001823
Expression of attacin by Relish [Drosophila]
Expression of drosomycin by Relish
event
Expression of drosomycin by Relish [Drosophila]
IMR:0001814
http://purl.org/obo/owl/IMR#IMR_0001814
IMR:0001818
http://purl.org/obo/owl/IMR#IMR_0001818
Transcription of attacin by Relish in nucleus
event
IMR:0001814
http://purl.org/obo/owl/IMR#IMR_0001814
Transcription of attacin by Relish [Drosophila]
IMR:0001823
http://purl.org/obo/owl/IMR#IMR_0001823
Expression of defensin by DIF:Relish
event
IMR:0001814
http://purl.org/obo/owl/IMR#IMR_0001814
IMR:0001806
http://purl.org/obo/owl/IMR#IMR_0001806
Expression of defensin by DIF:Relish [Drosophila]
IMR:0001828
http://purl.org/obo/owl/IMR#IMR_0001828
Transcription of antimicrobial peptide by Relish in nucleus
event
Transcription of antimicrobial peptide by Relish [Drosophila]
IMR:0001815
http://purl.org/obo/owl/IMR#IMR_0001815
IMR:0001814
http://purl.org/obo/owl/IMR#IMR_0001814
Transcription of drosomycin by Relish in nucleus
event
IMR:0001814
http://purl.org/obo/owl/IMR#IMR_0001814
IMR:0001818
http://purl.org/obo/owl/IMR#IMR_0001818
Transcription of drosomycin by Relish [Drosophila]
Transcription of cecropin by Relish in nucleus
event
IMR:0001814
http://purl.org/obo/owl/IMR#IMR_0001814
Transcription of cecropin by Relish [Drosophila]
IMR:0001819
http://purl.org/obo/owl/IMR#IMR_0001819
Transcription of defensin by DIF:Relish in nucleus
event
IMR:0001814
http://purl.org/obo/owl/IMR#IMR_0001814
IMR:0001828
http://purl.org/obo/owl/IMR#IMR_0001828
IMR:0001806
http://purl.org/obo/owl/IMR#IMR_0001806
Transcription of defensin by DIF:Relish [Drosophila]
Transcription of drosocin by Relish in nucleus
event
IMR:0001814
http://purl.org/obo/owl/IMR#IMR_0001814
IMR:0001827
http://purl.org/obo/owl/IMR#IMR_0001827
Transcription of drosocin by Relish [Drosophila]
Transcription of diptericin by Relish in nucleus
event
Transcription of diptericin by Relish [Drosophila]
IMR:0001814
http://purl.org/obo/owl/IMR#IMR_0001814
IMR:0001817
http://purl.org/obo/owl/IMR#IMR_0001817
Translation of drosomycin in cytosol
event
IMR:0001818
http://purl.org/obo/owl/IMR#IMR_0001818
Translation of drosomycin [Drosophila]
Translation of attacin in cytosol
event
IMR:0001823
http://purl.org/obo/owl/IMR#IMR_0001823
Translation of attacin [Drosophila]
Translation of cecropin in cytosol
event
IMR:0001819
http://purl.org/obo/owl/IMR#IMR_0001819
Translation of cecropin [Drosophila]
Translation of defensin in cytosol
event
IMR:0001828
http://purl.org/obo/owl/IMR#IMR_0001828
Translation of Defensin [Drosophila]
Translation of drosocin in cytosol
event
IMR:0001827
http://purl.org/obo/owl/IMR#IMR_0001827
Translation of drosocin [Drosophila]
Translation of diptericin in cytosol
event
IMR:0001817
http://purl.org/obo/owl/IMR#IMR_0001817
Translation of diptericin [Drosophila]
Toll receptor signaling
event
Tl signaling pathway
The series of molecular signals initiated by binding of a ligand to an extracellular ligand to the Toll receptor on the surface of the target cell.
GO:0008063
http://purl.org/obo/owl/GO#GO_0008063
Toll receptor signaling pathway
GO:0008063
http://purl.org/obo/owl/GO#GO_0008063
Drosophila Toll-like receptor signaling
Activation of serine protease in extracellular
event
IMR:0000304
http://purl.org/obo/owl/IMR#IMR_0000304
Activation of serine protease [Drosophila]
Activation of PSH by GNBP3 in extracellular
event
IMR:0001796
http://purl.org/obo/owl/IMR#IMR_0001796
IMR:0001795
http://purl.org/obo/owl/IMR#IMR_0001795
Activation of PSH by GNBP3 [Drosophila]
Autophosphorylation of Pelle in cytosol
event
IMR:0001802
http://purl.org/obo/owl/IMR#IMR_0001802
Autophosphorylation of Pelle [Drosophila]
Binding of GNBP3 and beta1-3 glucan in extracellular
event
IMR:0001795
http://purl.org/obo/owl/IMR#IMR_0001795
IMR:0001789
http://purl.org/obo/owl/IMR#IMR_0001789
Binding of GNBP3 and beta1-3 glucan [Drosophila]
Binding of TRAF2 and Ref2P:aPKC in cytosol
event
IMR:0100423
http://purl.org/obo/owl/IMR#IMR_0100423
Binding of dTRAF2 and Ref(2):DaPKC [Drosophila]
IMR:0001803
http://purl.org/obo/owl/IMR#IMR_0001803
Binding of TRAF2 and Ref(2):DaPKC in cytosol
IMR:0000247
http://purl.org/obo/owl/IMR#IMR_0000247
Binding of PGRP-SA and GNBP1 in extracellular
event
IMR:0001793
http://purl.org/obo/owl/IMR#IMR_0001793
IMR:0001785
http://purl.org/obo/owl/IMR#IMR_0001785
Binding of PGRP-SA and GNBP1 [Drosophila]
Binding of PGRP-SA:GNBP1 and PGN in extracellular
event
IMR:0001785
http://purl.org/obo/owl/IMR#IMR_0001785
Binding of PGRP-SA:GNBP1 and PGN [Drosophila]
IMR:0001793
http://purl.org/obo/owl/IMR#IMR_0001793
IMR:0001699
http://purl.org/obo/owl/IMR#IMR_0001699
Binding of PGRP-SD and PGN in extracellular
event
Binding of PGRP-SD and PGN [Drosophila]
IMR:0001786
http://purl.org/obo/owl/IMR#IMR_0001786
IMR:0001699
http://purl.org/obo/owl/IMR#IMR_0001699
Binding of Toll and MyD88:Tube in cytosol
event
IMR:0100465
http://purl.org/obo/owl/IMR#IMR_0100465
IMR:0001799
http://purl.org/obo/owl/IMR#IMR_0001799
IMR:0001467
http://purl.org/obo/owl/IMR#IMR_0001467
Binding of Toll and dMyD88:Tube [Drosophila]
Binding of Toll and Spaetzle in extracellular
event
IMR:0001467
http://purl.org/obo/owl/IMR#IMR_0001467
Binding of Toll and Spaetzle [Drosophila]
IMR:0001798
http://purl.org/obo/owl/IMR#IMR_0001798
Binding of Toll:MyD88:Tube and Pelle in cytosol
event
Binding of Toll:dMyD88:Tube and Pelle [Drosophila]
IMR:0001467
http://purl.org/obo/owl/IMR#IMR_0001467
IMR:0001799
http://purl.org/obo/owl/IMR#IMR_0001799
IMR:0001802
http://purl.org/obo/owl/IMR#IMR_0001802
IMR:0100465
http://purl.org/obo/owl/IMR#IMR_0100465
Cleavage of Spaetzle by serine protease in extracellular
event
IMR:0001798
http://purl.org/obo/owl/IMR#IMR_0001798
IMR:0000304
http://purl.org/obo/owl/IMR#IMR_0000304
Cleavage of Spaetzle by serine protease [Drosophila]
Activation of Spaetzle by PSH in extracellular
event
Activation of Spaetzle by PSH [Drosophila]
IMR:0001796
http://purl.org/obo/owl/IMR#IMR_0001796
IMR:0001798
http://purl.org/obo/owl/IMR#IMR_0001798
Activation of Spaetzle by serine protease in extracellular
event
IMR:0000304
http://purl.org/obo/owl/IMR#IMR_0000304
IMR:0001798
http://purl.org/obo/owl/IMR#IMR_0001798
Activation of Spaetzle by serine protease [Drosophila]
Cleavage of Spaetzle by PSH in extracellular
event
IMR:0001796
http://purl.org/obo/owl/IMR#IMR_0001796
IMR:0001798
http://purl.org/obo/owl/IMR#IMR_0001798
Cleavage of Spaetzle by PSH [Drosophila]
DIF signaling
event
DIF signaling [Drosophila]
Dorsal signaling
event
Dorsal signaling [Drosophila]
DIF:Dorsal signaling
event
DIF:Dorsal signaling [Drosophila]
Activation of DIF in cytosol
event
Activation of DIF [Drosophila]
IMR:0001806
http://purl.org/obo/owl/IMR#IMR_0001806
Dissociation of Cactus_p and DIF in cytosol
event
Dissociation of Cactus_p and DIF [Drosophila]
IMR:0001806
http://purl.org/obo/owl/IMR#IMR_0001806
IMR:0001805
http://purl.org/obo/owl/IMR#IMR_0001805
Expression of antimicrobial peptide by DIF
event
Expression of antimicrobial peptide by DIF [Drosophila]
IMR:0001815
http://purl.org/obo/owl/IMR#IMR_0001815
IMR:0001806
http://purl.org/obo/owl/IMR#IMR_0001806
Binding of DIF and NF-kappaB binding sequence in inner space of nucleus
event
IGS:0000010
http://purl.org/obo/owl/IGS#IGS_0000010
IMR:0001806
http://purl.org/obo/owl/IMR#IMR_0001806
Binding of DIF and NF-kappaB binding sequence [Drosophila]
Expression of cecropin by DIF
event
Expression of cecropin by DIF [Drosophila]
IMR:0001819
http://purl.org/obo/owl/IMR#IMR_0001819
IMR:0001806
http://purl.org/obo/owl/IMR#IMR_0001806
Expression of diptericin by DIF
event
Expression of diptericin by DIF [Drosophila]
IMR:0001806
http://purl.org/obo/owl/IMR#IMR_0001806
IMR:0001817
http://purl.org/obo/owl/IMR#IMR_0001817
Expression of drosomycin by DIF
event
IMR:0001818
http://purl.org/obo/owl/IMR#IMR_0001818
IMR:0001806
http://purl.org/obo/owl/IMR#IMR_0001806
Expression of drosomycin by DIF [Drosophila]
Transcription of cecropin by DIF in nucleus
event
IMR:0001819
http://purl.org/obo/owl/IMR#IMR_0001819
Transcription of cecropin by DIF [Drosophila]
IMR:0001806
http://purl.org/obo/owl/IMR#IMR_0001806
Transcription of antimicrobial peptide by DIF in nucleus
event
IMR:0001815
http://purl.org/obo/owl/IMR#IMR_0001815
IMR:0001806
http://purl.org/obo/owl/IMR#IMR_0001806
Transcription of antimicrobial peptide by DIF [Drosophila]
Transcription of antimicrobial peptide in nucleus
event
IMR:0001815
http://purl.org/obo/owl/IMR#IMR_0001815
Transcription of antimicrobial peptide [Drosophila]
Transcription of drosomycin by DIF in nucleus
event
IMR:0001806
http://purl.org/obo/owl/IMR#IMR_0001806
IMR:0001818
http://purl.org/obo/owl/IMR#IMR_0001818
Transcription of drosomycin by DIF [Drosophila]
Transcription of diptericin by DIF in nucleus
event
Transcription of diptericin by DIF [Drosophila]
IMR:0001806
http://purl.org/obo/owl/IMR#IMR_0001806
IMR:0001817
http://purl.org/obo/owl/IMR#IMR_0001817
Nuclear import of DIF
event
IMR:0001806
http://purl.org/obo/owl/IMR#IMR_0001806
Nuclear import of DIF [Drosophila]
Phosphorylation of Cactus in cytosol
event
Phosphorylation of Cactus [Drosophila]
IMR:0001805
http://purl.org/obo/owl/IMR#IMR_0001805
Activation of DIF:Dorsal in cytosol
event
IMR:0001807
http://purl.org/obo/owl/IMR#IMR_0001807
IMR:0001806
http://purl.org/obo/owl/IMR#IMR_0001806
Activation of DIF:Dorsal [Drosophila]
Dissociation of Cactus_p and Dorsal:DIF in cytosol
event
IMR:0001806
http://purl.org/obo/owl/IMR#IMR_0001806
IMR:0001805
http://purl.org/obo/owl/IMR#IMR_0001805
IMR:0001807
http://purl.org/obo/owl/IMR#IMR_0001807
Dissociation of Cactus_p and Dorsal:DIF [Drosophila]
Expression of antimicrobial peptide by DIF:Dorsal
event
IMR:0001815
http://purl.org/obo/owl/IMR#IMR_0001815
Expression of antimicrobial peptide by DIF:Dorsal [Drosophila]
IMR:0001807
http://purl.org/obo/owl/IMR#IMR_0001807
IMR:0001806
http://purl.org/obo/owl/IMR#IMR_0001806
Binding of DIF:Dorsal and NF-kappaB binding sequence in inner space of nucleus
event
IGS:0000010
http://purl.org/obo/owl/IGS#IGS_0000010
Binding of DIF:Dorsal and NF-kappaB binding sequence [Drosophila]
IMR:0001806
http://purl.org/obo/owl/IMR#IMR_0001806
IMR:0001807
http://purl.org/obo/owl/IMR#IMR_0001807
Transcription of antimicrobial peptide by DIF:Dorsal in nucleus
event
IMR:0001806
http://purl.org/obo/owl/IMR#IMR_0001806
Transcription of antimicrobial peptide by DIF:Dorsal [Drosophila]
IMR:0001807
http://purl.org/obo/owl/IMR#IMR_0001807
IMR:0001815
http://purl.org/obo/owl/IMR#IMR_0001815
Nuclear import of Dorsal:DIF
event
IMR:0001806
http://purl.org/obo/owl/IMR#IMR_0001806
IMR:0001807
http://purl.org/obo/owl/IMR#IMR_0001807
Nuclear import of Dorsal:DIF [Drosophila]
Dimerization of Toll by Spaetzle in plasma membrane
event
Dimerization of Toll by Spaetzle [Drosophila]
IMR:0001798
http://purl.org/obo/owl/IMR#IMR_0001798
IMR:0001467
http://purl.org/obo/owl/IMR#IMR_0001467
Dissociation of Toll:MyD88:Tube and Pelle in cytosol
event
Dissociation of Toll:dMyD88:Tube and Pelle [Drosophila]
IMR:0001467
http://purl.org/obo/owl/IMR#IMR_0001467
IMR:0001799
http://purl.org/obo/owl/IMR#IMR_0001799
IMR:0001802
http://purl.org/obo/owl/IMR#IMR_0001802
IMR:0100465
http://purl.org/obo/owl/IMR#IMR_0100465
Activation of Dorsal in cytosol
event
Activation of Dorsal [Drosophila]
IMR:0001807
http://purl.org/obo/owl/IMR#IMR_0001807
Dissociation of Cactus_p and Dorsal in cytosol
event
Dissociation of Cactus_p and Dorsal [Drosophila]
IMR:0001805
http://purl.org/obo/owl/IMR#IMR_0001805
IMR:0001807
http://purl.org/obo/owl/IMR#IMR_0001807
Expression of antimicrobial peptide by Dorsal
event
IMR:0001807
http://purl.org/obo/owl/IMR#IMR_0001807
Expression of antimicrobial peptide by Dorsal [Drosophila]
IMR:0001815
http://purl.org/obo/owl/IMR#IMR_0001815
Binding of Dorsal and NF-kappaB binding sequence in inner space of nucleus
event
IMR:0001807
http://purl.org/obo/owl/IMR#IMR_0001807
IGS:0000010
http://purl.org/obo/owl/IGS#IGS_0000010
Binding of Dorsal and NF-kappaB binding sequence [Drosophila]
Expression of drosomycin by Dorsal
event
Expression of drosomycin by Dorsal [Drosophila]
IMR:0001807
http://purl.org/obo/owl/IMR#IMR_0001807
IMR:0001818
http://purl.org/obo/owl/IMR#IMR_0001818
Transcription of drosomycin by Dorsal in nucleus
event
IMR:0001818
http://purl.org/obo/owl/IMR#IMR_0001818
IMR:0001807
http://purl.org/obo/owl/IMR#IMR_0001807
Transcription of drosomycin by Dorsal [Drosophila]
Transcription of antimicrobial peptide by Dorsal in nucleus
event
Transcription of antimicrobial peptide by Dorsal [Drosophila]
IMR:0001815
http://purl.org/obo/owl/IMR#IMR_0001815
IMR:0001807
http://purl.org/obo/owl/IMR#IMR_0001807
Nuclear import of Dorsal
event
IMR:0001807
http://purl.org/obo/owl/IMR#IMR_0001807
Nuclear import of Dorsal [Drosophila]
Nuclear import of TRAF2:Ref2P:aPKC
event
IMR:0000247
http://purl.org/obo/owl/IMR#IMR_0000247
Nuclear import of TRAF2:Ref(2)P:DaPKC
IMR:0001803
http://purl.org/obo/owl/IMR#IMR_0001803
Nuclear import of dTRAF2:Ref(2)P:DaPKC [Drosophila]
IMR:0100423
http://purl.org/obo/owl/IMR#IMR_0100423
Phosphorylation of TRAF2 by Pelle_p in cytosol
event
IMR:0001802
http://purl.org/obo/owl/IMR#IMR_0001802
IMR:0100423
http://purl.org/obo/owl/IMR#IMR_0100423
Phosphorylation of dTRAF2 by Pelle_p [Drosophila]
Activation of Deltex in cytosol
event
Activation of Deltex [Mammalian]
Activation of Deltex [Drosophila]
IMR:0001935
http://purl.org/obo/owl/IMR#IMR_0001935
Activation of Numb in cytosol
event
Activation of Numb [Mammalian]
IMR:0001955
http://purl.org/obo/owl/IMR#IMR_0001955
Regulation of Ras-Raf-MAPK signaling by spred
event
Regulation of Ras-Raf-MAPK signaling by spred [Drosophila]
Negative regulation of Ras-Raf-MAPK signaling by spred
event
Negative regulation of Ras-Raf-MAPK signaling by spred (Drosophila)
Positive regulation of Ras-Raf-MAPK signaling by spred
event
Positive regulation of Ras-Raf-MAPK signaling by spred (Drosophila)
Negative feedback regulation of Ras-Raf-MAPK signaling by spred
event
Negative feedback regulation of Ras-Raf-MAPK signaling by spred (Drosophila)
Negative feedback regulation of Ras-Raf-MAPK signaling by Sprouty
event
Negative feedback regulation of Ras-Raf-MAPK signaling by Sprouty (Drosophila)
IMR:0002072
http://purl.org/obo/owl/IMR#IMR_0002072
Inactivation in plasma membrane
event
Transcription in nucleus
event
Translation in cytosol
event
Binding of IGF-1 and IGF-1 receptor in extracellular
event
IMR:0100144
http://purl.org/obo/owl/IMR#IMR_0100144
IMR:0100677
http://purl.org/obo/owl/IMR#IMR_0100677
Autophosphorylation of IGF-1 receptor in plasma membrane
event
IMR:0100677
http://purl.org/obo/owl/IMR#IMR_0100677
Binding of IGF-1 receptor_p and Shc in cytosol
event
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
IMR:0100677
http://purl.org/obo/owl/IMR#IMR_0100677
Phosphorylation of Shc by IGF receptor_p in cytosol
event
IMR:0100677
http://purl.org/obo/owl/IMR#IMR_0100677
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
Binding of IGF-1 receptor_p and IRS-1 in cytosol
event
IMR:0100393
http://purl.org/obo/owl/IMR#IMR_0100393
IMR:0100677
http://purl.org/obo/owl/IMR#IMR_0100677
Phosphorylation of IRS-1 by IGF-1 receptor in cytosol
event
IMR:0100677
http://purl.org/obo/owl/IMR#IMR_0100677
IMR:0100393
http://purl.org/obo/owl/IMR#IMR_0100393
Binding of IRS-1_p and PI3K in cytosol
event
IMR:0100393
http://purl.org/obo/owl/IMR#IMR_0100393
IMR:0000265
http://purl.org/obo/owl/IMR#IMR_0000265
Binding of IRS-1_p and Grb2 in cytosol
event
IMR:0000340
http://purl.org/obo/owl/IMR#IMR_0000340
IMR:0100393
http://purl.org/obo/owl/IMR#IMR_0100393
IGF1 signaling pathway
event
Negative regulation of IGF1 signaling pathway
event
Binding of IGF-1 and IGFBP in extracellular
event
IMR:0002688
http://purl.org/obo/owl/IMR#IMR_0002688
IMR:0100144
http://purl.org/obo/owl/IMR#IMR_0100144
Regulation of IGF1 signaling pathway
event
Positive regulation of IGF1 signaling pathway
event
Binding of IGF-1 and IGFBP-3 in extracellular
event
IMR:0002691
http://purl.org/obo/owl/IMR#IMR_0002691
IMR:0100144
http://purl.org/obo/owl/IMR#IMR_0100144
Cleavage of IGFBP-3 by PSA in extracellular
event
IMR:0002691
http://purl.org/obo/owl/IMR#IMR_0002691
IMR:0002713
http://purl.org/obo/owl/IMR#IMR_0002713
Binding of IGF-1 and IGFBP-5 in extracellular
event
IMR:0100144
http://purl.org/obo/owl/IMR#IMR_0100144
IMR:0002693
http://purl.org/obo/owl/IMR#IMR_0002693
Complex formation of Estrogen receptor in cytosol
event
IMR:0000088
http://purl.org/obo/owl/IMR#IMR_0000088
Binding of Estrogen and Estrogen receptor in cytosol
event
IMR:0000088
http://purl.org/obo/owl/IMR#IMR_0000088
CHEBI:50114
http://purl.org/obo/owl/CHEBI#CHEBI_50114
Regulation of Toll receptor signaling
event
regulation of Tl signaling pathway
Regulation of Toll receptor signaling pathway
GO:0008592
http://purl.org/obo/owl/GO#GO_0008592
Any process that modulates the frequency, rate or extent of the Tl signaling pathway.
GO:0008592
http://purl.org/obo/owl/GO#GO_0008592
Binding of BMP2 and BMP receptor II in extracellular
event
IMR:0000702
http://purl.org/obo/owl/IMR#IMR_0000702
IMR:0001424
http://purl.org/obo/owl/IMR#IMR_0001424
Binding of BMP and BMP receptor II in extracellular
event
IMR:0000702
http://purl.org/obo/owl/IMR#IMR_0000702
IMR:0000040
http://purl.org/obo/owl/IMR#IMR_0000040
Binding of BMP2:BMP receptor II and BMP receptor I in extracellular
event
IMR:0000702
http://purl.org/obo/owl/IMR#IMR_0000702
IMR:0001424
http://purl.org/obo/owl/IMR#IMR_0001424
IMR:0001425
http://purl.org/obo/owl/IMR#IMR_0001425
Binding of BMP and BMP receptor I/II in extracellular
event
IMR:0000702
http://purl.org/obo/owl/IMR#IMR_0000702
IMR:0001425
http://purl.org/obo/owl/IMR#IMR_0001425
IMR:0000040
http://purl.org/obo/owl/IMR#IMR_0000040
Binding of BMP:BMP receptor II and BMP receptor I in plasma membrane
event
IMR:0000040
http://purl.org/obo/owl/IMR#IMR_0000040
IMR:0000702
http://purl.org/obo/owl/IMR#IMR_0000702
IMR:0001425
http://purl.org/obo/owl/IMR#IMR_0001425
Complex formation of Smad5 and Smad4 in cytosol
event
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
IMR:0100313
http://purl.org/obo/owl/IMR#IMR_0100313
Complex formation of Smad8 and Smad4 in cytosol
event
IMR:0100314
http://purl.org/obo/owl/IMR#IMR_0100314
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
Complex formation of Smad2 and Smad4 in cytosol
event
IMR:0100311
http://purl.org/obo/owl/IMR#IMR_0100311
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
Complex formation of Smad3 and Smad4 in cytosol
event
IMR:0100312
http://purl.org/obo/owl/IMR#IMR_0100312
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
Binding of BMP receptor complex and Smad1 in cytosol
event
IMR:0000702
http://purl.org/obo/owl/IMR#IMR_0000702
IMR:0001425
http://purl.org/obo/owl/IMR#IMR_0001425
IMR:0100310
http://purl.org/obo/owl/IMR#IMR_0100310
Dissociation of BMP receptor complex and Smad1 in cytosol
event
IMR:0001425
http://purl.org/obo/owl/IMR#IMR_0001425
IMR:0100310
http://purl.org/obo/owl/IMR#IMR_0100310
IMR:0000702
http://purl.org/obo/owl/IMR#IMR_0000702
Binding of BMP receptor complex and R-Smad in cytosol
event
IMR:0000702
http://purl.org/obo/owl/IMR#IMR_0000702
IMR:0001425
http://purl.org/obo/owl/IMR#IMR_0001425
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
Dissociation of BMP receptor complex and R-Smad in cytosol
event
IMR:0001425
http://purl.org/obo/owl/IMR#IMR_0001425
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
IMR:0000702
http://purl.org/obo/owl/IMR#IMR_0000702
Phosphorylation of TGF beta superfamily receptor I by TGF beta superfamily receptor II in cytosol
event
IMR:0000094
http://purl.org/obo/owl/IMR#IMR_0000094
IMR:0000093
http://purl.org/obo/owl/IMR#IMR_0000093
Phosphorylation of R-Smad by TGF beta superfamily receptor I in cytosol
event
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
IMR:0000093
http://purl.org/obo/owl/IMR#IMR_0000093
Phosphorylation of R-Smad by BMP receptor I in cytosol
event
IMR:0001425
http://purl.org/obo/owl/IMR#IMR_0001425
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
Complex formation of R-Smad and Co-Smad in cytosol
event
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
IMR:0000372
http://purl.org/obo/owl/IMR#IMR_0000372
Cleavage of BMP in extracellular
event
IMR:0000040
http://purl.org/obo/owl/IMR#IMR_0000040
Dephosphorylation of R-Smad in inner space of nucleus
event
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
Dissociation of R-Smad and Smad4 in inner space of nucleus
event
IMR:0100315
http://purl.org/obo/owl/IMR#IMR_0100315
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
Nuclear export of R-Smad
event
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
Dissociation of TGF beta superfamily receptor complex and R-Smad in cytosol
event
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
IMR:0000092
http://purl.org/obo/owl/IMR#IMR_0000092
Binding of TGF beta superfamily receptor complex and R-Smad in cytosol
event
IMR:0000092
http://purl.org/obo/owl/IMR#IMR_0000092
IMR:0000371
http://purl.org/obo/owl/IMR#IMR_0000371
Binding of TGF beta super family:Type II receptor and Type I receptor in plasma membrane
event
IEV:0001256
Complex formation of TGF beta superfamily receptor in plasma membrane
TGF beta superfamily receptor complex formation
IMR:0000094
http://purl.org/obo/owl/IMR#IMR_0000094
The aggregation and bonding together of a type II transforming growth factor beta (TGFbeta) receptor dimer with a type I TGFbeta receptor dimer, following ligand binding, to form a heterotetrameric TGFbeta receptor complex.
XX:<new_dbxref>
http://purl.org/obo/owl/XX#XX_<new_dbxref>
IMR:0000036
http://purl.org/obo/owl/IMR#IMR_0000036
IMR:0000093
http://purl.org/obo/owl/IMR#IMR_0000093
GO:0007181
http://purl.org/obo/owl/GO#GO_0007181
Binding of TGF beta superfamily and TGF beta superfamily receptor II in extracellular
event
IMR:0000036
http://purl.org/obo/owl/IMR#IMR_0000036
IMR:0000094
http://purl.org/obo/owl/IMR#IMR_0000094
IL23 signaling pathway (JAK2, TYK2, STAT3, STAT4)
event
Binding of IL-23 and IL-23 receptor and conformational change of receptors in plasma membrane
event
IMR:0002717
http://purl.org/obo/owl/IMR#IMR_0002717
IMR:0002716
http://purl.org/obo/owl/IMR#IMR_0002716
Phosphorylation of IL-23 receptor by JAK2 and TYK2 in cytosol
event
IMR:0002717
http://purl.org/obo/owl/IMR#IMR_0002717
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
IMR:0100322
http://purl.org/obo/owl/IMR#IMR_0100322
Binding of IL-23 receptor and STAT4 in cytosol
event
IMR:0002717
http://purl.org/obo/owl/IMR#IMR_0002717
IMR:0000378
http://purl.org/obo/owl/IMR#IMR_0000378
Binding of IL-23 receptor and STAT3 in cytosol
event
IMR:0002717
http://purl.org/obo/owl/IMR#IMR_0002717
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
Phosphorylation of STAT3 by JAK2_p and TYK2_p in cytosol
event
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
IMR:0100322
http://purl.org/obo/owl/IMR#IMR_0100322
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
Dissociation of IL-23 receptor and STAT3 in cytosol
event
IMR:0002717
http://purl.org/obo/owl/IMR#IMR_0002717
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
Dissociation of IL-23 receptor and STAT4 in cytosol
event
IMR:0000378
http://purl.org/obo/owl/IMR#IMR_0000378
IMR:0002717
http://purl.org/obo/owl/IMR#IMR_0002717
Dimerization of STAT3 and STAT4 in cytosol
event
IMR:0000378
http://purl.org/obo/owl/IMR#IMR_0000378
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
Nuclear import of STAT3:STAT4 heterodimer
event
IMR:0000378
http://purl.org/obo/owl/IMR#IMR_0000378
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
Binding of STAT3:STAT4 heterodimer and responsive element in inner space of nucleus
event
IMR:0000377
http://purl.org/obo/owl/IMR#IMR_0000377
IMR:0000378
http://purl.org/obo/owl/IMR#IMR_0000378
IGS:0000028
http://purl.org/obo/owl/IGS#IGS_0000028
RNA cleavage
event
MI:0902
http://purl.org/obo/owl/MI#MI_0902
GO:0006396
http://purl.org/obo/owl/GO#GO_0006396
Any process by which an RNA molecule is cleaved at specific sites or in a regulated manner.
MI:0902
http://purl.org/obo/owl/MI#MI_0902
nucleic acid cleavage
event
Covalent bond breakage of a nucleic acid molecule leading to the formation of smaller fragments.
MI:0910
http://purl.org/obo/owl/MI#MI_0910
MI:0910
http://purl.org/obo/owl/MI#MI_0910
Phosphorylation of STAT6 by JAK1_p and TYK2_p in cytosol
event
IMR:0100322
http://purl.org/obo/owl/IMR#IMR_0100322
IMR:0000381
http://purl.org/obo/owl/IMR#IMR_0000381
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IL13 signaling pathway (JAK1, TYK2, STAT6)
event
Binding of IL-13 and IL-13 receptor and conformational change of receptors in plasma membrane
event
IMR:0000115
http://purl.org/obo/owl/IMR#IMR_0000115
IMR:0000595
http://purl.org/obo/owl/IMR#IMR_0000595
Phosphorylation of IL-4 receptor by JAK1 and TYK2 in cytosol
event
IMR:0100319
http://purl.org/obo/owl/IMR#IMR_0100319
IMR:0000107
http://purl.org/obo/owl/IMR#IMR_0000107
IMR:0100322
http://purl.org/obo/owl/IMR#IMR_0100322
Regulation of IL13 signaling pathway (JAK1, TYK2, STAT6)
event
Negative regulation of IL13 signaling pathway (JAK1, TYK2, STAT6)
event
Binding of IL-13 and IL-13 receptor in extracellular
event
IMR:0000115
http://purl.org/obo/owl/IMR#IMR_0000115
IMR:0000595
http://purl.org/obo/owl/IMR#IMR_0000595
Binding of IL-5 receptor and Shc in cytosol
event
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
IMR:0000101
http://purl.org/obo/owl/IMR#IMR_0000101
Phosphorylation of Shc by JAK2_p in cytosol
event
IMR:0000347
http://purl.org/obo/owl/IMR#IMR_0000347
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
Binding of IRS and IL-4 receptor in cytosol
event
IMR:0000107
http://purl.org/obo/owl/IMR#IMR_0000107
IMR:0000351
http://purl.org/obo/owl/IMR#IMR_0000351
Binding of IRS-1 and IL-4 receptor in cytosol
event
IMR:0100393
http://purl.org/obo/owl/IMR#IMR_0100393
IMR:0000107
http://purl.org/obo/owl/IMR#IMR_0000107
Binding of IRS-2 and IL-4 receptor in cytosol
event
IMR:0000107
http://purl.org/obo/owl/IMR#IMR_0000107
IMR:0100394
http://purl.org/obo/owl/IMR#IMR_0100394
IL5 signaling pathway (JAK1, JAK2, STAT1, STAT5)
event
Binding of IL5 and IL5 receptor and conformational change of receptors in plasma membrane
event
IMR:0000009
http://purl.org/obo/owl/IMR#IMR_0000009
IMR:0000101
http://purl.org/obo/owl/IMR#IMR_0000101
Phosphorylation of IL-5 receptor and JAK2 in cytosol
event
IMR:0100320
http://purl.org/obo/owl/IMR#IMR_0100320
IMR:0000101
http://purl.org/obo/owl/IMR#IMR_0000101
Binding of IL-5 receptor and STAT5 in cytosol
event
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
IMR:0000101
http://purl.org/obo/owl/IMR#IMR_0000101
Binding of IL-5 receptor and STAT1 in cytosol
event
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
IMR:0000101
http://purl.org/obo/owl/IMR#IMR_0000101
Dissociation of IL-5 receptor and STAT5 in cytosol
event
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
IMR:0000101
http://purl.org/obo/owl/IMR#IMR_0000101
Dissociation of IL-5 receptor and STAT1 in cytosol
event
IMR:0000375
http://purl.org/obo/owl/IMR#IMR_0000375
IMR:0000101
http://purl.org/obo/owl/IMR#IMR_0000101
Binding of insulin receptor and PI3K in cytosol
event
IMR:0000265
http://purl.org/obo/owl/IMR#IMR_0000265
IMR:0000078
http://purl.org/obo/owl/IMR#IMR_0000078
Gene expression by FOXO
IEV:0003649
event
Gene expression by Forkhead box domain transcription factor
IMR:0002804
http://purl.org/obo/owl/IMR#IMR_0002804
Binding of insulin receptor and Grb2 in cytosol
event
IMR:0000340
http://purl.org/obo/owl/IMR#IMR_0000340
IMR:0000078
http://purl.org/obo/owl/IMR#IMR_0000078
Dephosphorylation of Raf by PP2A in cytosol
event
IMR:0000280
http://purl.org/obo/owl/IMR#IMR_0000280
IMR:0000231
http://purl.org/obo/owl/IMR#IMR_0000231
Binding of Ras-GTP and Raf in cytosol
event
IMR:0000290
http://purl.org/obo/owl/IMR#IMR_0000290
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000231
http://purl.org/obo/owl/IMR#IMR_0000231
Dissociation of Ras-GTP and Raf in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000290
http://purl.org/obo/owl/IMR#IMR_0000290
IMR:0000231
http://purl.org/obo/owl/IMR#IMR_0000231
Phosphorylation of TSC2 by AKT in cytosol
event
IMR:0002759
http://purl.org/obo/owl/IMR#IMR_0002759
IMR:0000250
http://purl.org/obo/owl/IMR#IMR_0000250
Hydrolysis of GTP by Rheb and TSC2 in cytosol
event
IMR:0002759
http://purl.org/obo/owl/IMR#IMR_0002759
IMR:0002752
http://purl.org/obo/owl/IMR#IMR_0002752
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
GDP-GTP exchange of Rheb in cytosol
event
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0002752
http://purl.org/obo/owl/IMR#IMR_0002752
Activation of TORC1 in cytosol
event
IMR:0002721
http://purl.org/obo/owl/IMR#IMR_0002721
IMR:0002730
http://purl.org/obo/owl/IMR#IMR_0002730
IMR:0002736
http://purl.org/obo/owl/IMR#IMR_0002736
Activation of TOR:LST8:Raptor in cytosol
Binding of eIF4F and mRNA in cytosol
event
IMR:0000909
http://purl.org/obo/owl/IMR#IMR_0000909
Phosphorylation of p70S6K by TOR of TORC1 in cytosol
event
Phosphorylation of p70S6K by TOR of TOR:LST8:Raptor in cytosol
IMR:0001845
http://purl.org/obo/owl/IMR#IMR_0001845
IMR:0002721
http://purl.org/obo/owl/IMR#IMR_0002721
IMR:0002730
http://purl.org/obo/owl/IMR#IMR_0002730
IMR:0002736
http://purl.org/obo/owl/IMR#IMR_0002736
Phosphorylation of 4EBP-1 by TOR of TORC1 in cytosol
event
IMR:0002730
http://purl.org/obo/owl/IMR#IMR_0002730
IMR:0002721
http://purl.org/obo/owl/IMR#IMR_0002721
Phosphorylation of 4EBP-1 by TOR of TOR:LST8:Raptor in cytosol
IMR:0011156
http://purl.org/obo/owl/IMR#IMR_0011156
IMR:0002736
http://purl.org/obo/owl/IMR#IMR_0002736
Phosphorylation of S6RP by S6K1 in cytosol
event
IMR:0100711
http://purl.org/obo/owl/IMR#IMR_0100711
IMR:0002798
http://purl.org/obo/owl/IMR#IMR_0002798
Phosphorylation of S6RP by p70S6K in cytosol
event
IMR:0100711
http://purl.org/obo/owl/IMR#IMR_0100711
IMR:0001845
http://purl.org/obo/owl/IMR#IMR_0001845
Dissociation of 4EBP-1 and eIF4E in cytosol
event
IMR:0011155
http://purl.org/obo/owl/IMR#IMR_0011155
IMR:0011156
http://purl.org/obo/owl/IMR#IMR_0011156
Complex formation of eIF4F in cytosol
event
IMR:0000909
http://purl.org/obo/owl/IMR#IMR_0000909
Binding of 4EBP-1 and eIF4E in cytosol
event
IMR:0011155
http://purl.org/obo/owl/IMR#IMR_0011155
IMR:0011156
http://purl.org/obo/owl/IMR#IMR_0011156
Binding of rapamycin:FKBP12 and TOR in cytosol
event
IMR:0002818
http://purl.org/obo/owl/IMR#IMR_0002818
IMR:0002721
http://purl.org/obo/owl/IMR#IMR_0002721
IMR:0100489
http://purl.org/obo/owl/IMR#IMR_0100489
Phosphorylation of Glycogen synthase by GSK3b in cytosol
event
IMR:0002770
http://purl.org/obo/owl/IMR#IMR_0002770
IMR:0100737
http://purl.org/obo/owl/IMR#IMR_0100737
Phosphorylation of TSC2 by AMPK in cytosol
event
IMR:0002775
http://purl.org/obo/owl/IMR#IMR_0002775
IMR:0002759
http://purl.org/obo/owl/IMR#IMR_0002759
Phosphorylation of TSC2 by GSK3b in cytosol
event
IMR:0002759
http://purl.org/obo/owl/IMR#IMR_0002759
IMR:0100737
http://purl.org/obo/owl/IMR#IMR_0100737
Nuclear import of AKT
event
IMR:0000250
http://purl.org/obo/owl/IMR#IMR_0000250
Negative regulation of transcription by AKT
event
IMR:0000250
http://purl.org/obo/owl/IMR#IMR_0000250
Phosphorylation of AKT by TOR of TORC2 in cytosol
event
IMR:0002742
http://purl.org/obo/owl/IMR#IMR_0002742
IMR:0002747
http://purl.org/obo/owl/IMR#IMR_0002747
IMR:0000250
http://purl.org/obo/owl/IMR#IMR_0000250
IMR:0002721
http://purl.org/obo/owl/IMR#IMR_0002721
IMR:0002736
http://purl.org/obo/owl/IMR#IMR_0002736
Phosphorylation of AKT by TOR of TOR:LST8:SIN1:Rictor in cytosol
Circulatory system process
event
A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.
GO:0003013
http://purl.org/obo/owl/GO#GO_0003013
GO:0003013
http://purl.org/obo/owl/GO#GO_0003013
Phosphorylation of FOXO by AKT in inner space of nucleus
event
IEV:0003653
Phosphorylation of Forkhead box transcription factor by AKT in inner space of nucleus
IMR:0002804
http://purl.org/obo/owl/IMR#IMR_0002804
IMR:0000250
http://purl.org/obo/owl/IMR#IMR_0000250
Binding of FOXO and responsive element in inner space of nucleus
IEV:0003650
event
Binding of Forkhead box domain transcription factor and responsive element in inner space of nucleus
IGS:0000028
http://purl.org/obo/owl/IGS#IGS_0000028
IMR:0002804
http://purl.org/obo/owl/IMR#IMR_0002804
Transcription of FOXO target gene in nucleus
IEV:0003651
event
IMR:0002804
http://purl.org/obo/owl/IMR#IMR_0002804
Transcription of Forkhead box transcription factor target gene in nucleus
Muscle system process
event
A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.
GO:0003012
http://purl.org/obo/owl/GO#GO_0003012
GO:0003012
http://purl.org/obo/owl/GO#GO_0003012
Gene expression of MAFbx by FOXO
event
UniProt:Q969P5
http://purl.org/obo/owl/UniProt#UniProt_Q969P5
IMR:0002804
http://purl.org/obo/owl/IMR#IMR_0002804
Gene expression of MuRF1 by FOXO
event
IMR:0002804
http://purl.org/obo/owl/IMR#IMR_0002804
UniProt:Q969Q1
http://purl.org/obo/owl/UniProt#UniProt_Q969Q1
Transcription of MAFbx in nucleus
event
UniProt:Q969P5
http://purl.org/obo/owl/UniProt#UniProt_Q969P5
Transcription of MuRF1 in nucleus
event
UniProt:Q969Q1
http://purl.org/obo/owl/UniProt#UniProt_Q969Q1
Binding of TORC1 and PRAS40 in cytosol
event
IMR:0002823
http://purl.org/obo/owl/IMR#IMR_0002823
IMR:0002736
http://purl.org/obo/owl/IMR#IMR_0002736
IMR:0002730
http://purl.org/obo/owl/IMR#IMR_0002730
IMR:0002721
http://purl.org/obo/owl/IMR#IMR_0002721
Binding of TOR:LST8:Raptor and PRAS40 in cytosol
Phosphorylation of PRAS40 by AKT in cytosol
event
IMR:0000250
http://purl.org/obo/owl/IMR#IMR_0000250
IMR:0002823
http://purl.org/obo/owl/IMR#IMR_0002823
Binding of TORC1 and FKBP38 in cytosol
event
IMR:0002721
http://purl.org/obo/owl/IMR#IMR_0002721
Binding of TOR:LST8:Raptor and FKBP38 in cytosol
IMR:0002736
http://purl.org/obo/owl/IMR#IMR_0002736
IMR:0002730
http://purl.org/obo/owl/IMR#IMR_0002730
IMR:0002826
http://purl.org/obo/owl/IMR#IMR_0002826
Binding of TSC1:TSC2 complex and TORC2 in cytosol
event
Binding of TSC1:TSC2 complex and TOR:LST8:SIN1:Rictor in cytosol
IMR:0002721
http://purl.org/obo/owl/IMR#IMR_0002721
IMR:0002764
http://purl.org/obo/owl/IMR#IMR_0002764
IMR:0002747
http://purl.org/obo/owl/IMR#IMR_0002747
IMR:0002759
http://purl.org/obo/owl/IMR#IMR_0002759
IMR:0002736
http://purl.org/obo/owl/IMR#IMR_0002736
IMR:0002742
http://purl.org/obo/owl/IMR#IMR_0002742
Skeletal muscle atrophy
event
GO:0014732
http://purl.org/obo/owl/GO#GO_0014732
A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse.
GO:0014732
http://purl.org/obo/owl/GO#GO_0014732
Dissociation of 4EBP and eIF4E in cytosol
event
IMR:0011155
http://purl.org/obo/owl/IMR#IMR_0011155
IMR:0000898
http://purl.org/obo/owl/IMR#IMR_0000898
Gene expression of 4EBP by FOXO
event
IMR:0002804
http://purl.org/obo/owl/IMR#IMR_0002804
IMR:0000898
http://purl.org/obo/owl/IMR#IMR_0000898
Negative regulation of FOXO-mediated transcription by AKT
event
IEV:0003657
Negative regulation of Forkhead box transcription factor-mediated transcription by AKT
IMR:0000250
http://purl.org/obo/owl/IMR#IMR_0000250
IMR:0002804
http://purl.org/obo/owl/IMR#IMR_0002804
Nuclear export of FOXO
IEV:0003654
event
Nuclear export of Forkhead box transcription factor
IMR:0002804
http://purl.org/obo/owl/IMR#IMR_0002804
Transcription of 4EBP in nucleus
event
IMR:0000898
http://purl.org/obo/owl/IMR#IMR_0000898
Binding of Melted and TSC1 in cytosol
event
IMR:0002764
http://purl.org/obo/owl/IMR#IMR_0002764
Regulation of AKT(PKB)-TOR signaling
event
Negative regulation of AKT(PKB)-TOR signaling
event
Positive regulation of AKT(PKB)-TOR signaling
event
signal transduction regulation pathway
event
Any process that modulates the frequency, rate or extent of a signaling pathway.
GO:0035466
http://purl.org/obo/owl/GO#GO_0035466
GO:0035466
http://purl.org/obo/owl/GO#GO_0035466
Regulation of G alpha-GTP hydrolysis signaling
event
Phosphorylation of FOXO by AKT in cytosol
event
IMR:0000250
http://purl.org/obo/owl/IMR#IMR_0000250
IMR:0002804
http://purl.org/obo/owl/IMR#IMR_0002804
Insulin receptor family signaling pathway
event
Transcription of Raptor gene in nucleus
event
IMR:0002730
http://purl.org/obo/owl/IMR#IMR_0002730
Gene expression of vvl by STAT dimer
event
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
IMR:0002932
http://purl.org/obo/owl/IMR#IMR_0002932
Transcription of vvl by STAT dimer in nucleus
event
IMR:0002932
http://purl.org/obo/owl/IMR#IMR_0002932
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
Nuclear export of mRNA (vvl)
event
IMR:0002932
http://purl.org/obo/owl/IMR#IMR_0002932
Translation of vvl in cytosol
event
IMR:0002932
http://purl.org/obo/owl/IMR#IMR_0002932
Binding of trans-activator and PIAS in inner space of nucleus
event
IMR:0002914
http://purl.org/obo/owl/IMR#IMR_0002914
Binding of STAT and PIAS in inner space of nucleus
event
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
IMR:0002914
http://purl.org/obo/owl/IMR#IMR_0002914
Binding of STAT and PIAS in cytosol
event
IMR:0002914
http://purl.org/obo/owl/IMR#IMR_0002914
IMR:0000374
http://purl.org/obo/owl/IMR#IMR_0000374
Negative regulation of transcription by BCL-6
event
IMR:0000417
http://purl.org/obo/owl/IMR#IMR_0000417
Binding of BCL-6 and GAS in inner space of nucleus
event
IMR:0000417
http://purl.org/obo/owl/IMR#IMR_0000417
IGS:0000018
http://purl.org/obo/owl/IGS#IGS_0000018
Negative regulation of transcription in JAK STAT pathway
event
Binding of trans-activator and PIAS in cytosol
event
IMR:0002914
http://purl.org/obo/owl/IMR#IMR_0002914
Binding of TGF alpha and EGFR in extracellular
event
IMR:0100278
http://purl.org/obo/owl/IMR#IMR_0100278
IMR:0000081
http://purl.org/obo/owl/IMR#IMR_0000081
Gene expression by ets domain transcription factor
event
IMR:0000397
http://purl.org/obo/owl/IMR#IMR_0000397
PubMed:11715049
http://purl.org/obo/owl/PubMed#PubMed_11715049
PubMed:11175369
http://purl.org/obo/owl/PubMed#PubMed_11175369
PubMed:9570133
http://purl.org/obo/owl/PubMed#PubMed_9570133
Gene expression by ETS1/2
event
IMR:0000399
http://purl.org/obo/owl/IMR#IMR_0000399
IMR:0000400
http://purl.org/obo/owl/IMR#IMR_0000400
Gene expression by Elk-1
event
IMR:0001094
http://purl.org/obo/owl/IMR#IMR_0001094
Negative regulation of FGFR1 signaling pathway
event
Phosphorylation of transcriptional regulator by MAPK_p in cytosol
event
Dually phosphorylated MAPK, or dpERK, phosphorylates protein targets in both the cytoplasm and nucleus.
PubMed:16771628
http://purl.org/obo/owl/PubMed#PubMed_16771628
IMR:0000369
http://purl.org/obo/owl/IMR#IMR_0000369
IMR:0000224
http://purl.org/obo/owl/IMR#IMR_0000224
Gene expression of Mae by ETS1
event
IMR:0002987
http://purl.org/obo/owl/IMR#IMR_0002987
IMR:0000399
http://purl.org/obo/owl/IMR#IMR_0000399
Nuclear export of mRNA (Mae)
event
IMR:0002987
http://purl.org/obo/owl/IMR#IMR_0002987
Transcription of Mae gene in nucleus
event
IMR:0002987
http://purl.org/obo/owl/IMR#IMR_0002987
Translation of Mae in cytosol
event
IMR:0002987
http://purl.org/obo/owl/IMR#IMR_0002987
Phosphorylation of Tel-1 by ERK1/2_p in inner space of nucleus
event
IMR:0000227
http://purl.org/obo/owl/IMR#IMR_0000227
IMR:0002980
http://purl.org/obo/owl/IMR#IMR_0002980
Binding of Tel-1 and responsive element in inner space of nucleus
event
IGS:0000028
http://purl.org/obo/owl/IGS#IGS_0000028
IMR:0002980
http://purl.org/obo/owl/IMR#IMR_0002980
Negative regulation of transcription by Tel-1
event
IMR:0002980
http://purl.org/obo/owl/IMR#IMR_0002980
Degradation
event
Binding TGF alpha and Star in extracellular
event
IMR:0100278
http://purl.org/obo/owl/IMR#IMR_0100278
IMR:0002965
http://purl.org/obo/owl/IMR#IMR_0002965
Translocation of TGF alpha:Star from ER to Golgi
event
IMR:0002965
http://purl.org/obo/owl/IMR#IMR_0002965
IMR:0100278
http://purl.org/obo/owl/IMR#IMR_0100278
Cleavage of TGF alpha by Rhomboid in Golgi
event
IMR:0002959
http://purl.org/obo/owl/IMR#IMR_0002959
IMR:0100278
http://purl.org/obo/owl/IMR#IMR_0100278
Cleavage in Golgi
event
Translocation of TGF alpha from Golgi to extracellular
event
IMR:0100278
http://purl.org/obo/owl/IMR#IMR_0100278
Translocation from Golgi to extracellular
event
Gene expression of Sprouty by ETS1/2
event
IMR:0002072
http://purl.org/obo/owl/IMR#IMR_0002072
IMR:0000400
http://purl.org/obo/owl/IMR#IMR_0000400
IMR:0000399
http://purl.org/obo/owl/IMR#IMR_0000399
Nuclear export of mRNA (Sprouty)
event
IMR:0002072
http://purl.org/obo/owl/IMR#IMR_0002072
Transcription of Sprouty gene in nucleus
event
IMR:0002072
http://purl.org/obo/owl/IMR#IMR_0002072
Translation of Sprouty in cytosol
event
IMR:0002072
http://purl.org/obo/owl/IMR#IMR_0002072
Gene expression of Argos by ETS1
event
IMR:0000399
http://purl.org/obo/owl/IMR#IMR_0000399
IMR:0002967
http://purl.org/obo/owl/IMR#IMR_0002967
Transcription of Argos gene in nucleus
event
IMR:0002967
http://purl.org/obo/owl/IMR#IMR_0002967
Nuclear export of mRNA (Argos)
event
IMR:0002967
http://purl.org/obo/owl/IMR#IMR_0002967
Translation of Argos gene in cytosol
event
IMR:0002967
http://purl.org/obo/owl/IMR#IMR_0002967
Gene expression of Kek by ETS1
event
IMR:0002988
http://purl.org/obo/owl/IMR#IMR_0002988
IMR:0000399
http://purl.org/obo/owl/IMR#IMR_0000399
Transcription of Kek gene in nucleus
event
IMR:0002988
http://purl.org/obo/owl/IMR#IMR_0002988
Nuclear export of mRNA (Kek)
event
IMR:0002988
http://purl.org/obo/owl/IMR#IMR_0002988
Translation of Kek gene in cytosol
event
IMR:0002988
http://purl.org/obo/owl/IMR#IMR_0002988
Binding of Tel-1 and Crm1 in inner space of nucleus
event
IMR:0002980
http://purl.org/obo/owl/IMR#IMR_0002980
IMR:0001090
http://purl.org/obo/owl/IMR#IMR_0001090
Nuclear export of Tel-1:Crm1
event
IMR:0001090
http://purl.org/obo/owl/IMR#IMR_0001090
IMR:0002980
http://purl.org/obo/owl/IMR#IMR_0002980
Binding of EGFR and Kek in plasma membrane
event
IMR:0002988
http://purl.org/obo/owl/IMR#IMR_0002988
IMR:0000081
http://purl.org/obo/owl/IMR#IMR_0000081
Translocation of Kek from cytosol to plasma membrane
event
IMR:0002988
http://purl.org/obo/owl/IMR#IMR_0002988
Negative feedback regulation of EGF receptor signaling by Sprouty
event
IMR:0002072
http://purl.org/obo/owl/IMR#IMR_0002072
Negative feedback regulation of EGF receptor signaling by Kek
event
IMR:0002988
http://purl.org/obo/owl/IMR#IMR_0002988
Negative feedback regulation of EGF receptor signaling by Argos
event
IMR:0002967
http://purl.org/obo/owl/IMR#IMR_0002967
Translocation of Argos from the cytosol to the extracellular
event
IMR:0002967
http://purl.org/obo/owl/IMR#IMR_0002967
Binding of Argos and TGF alpha in extracellular
event
IMR:0002967
http://purl.org/obo/owl/IMR#IMR_0002967
IMR:0100278
http://purl.org/obo/owl/IMR#IMR_0100278
Phosphorylation of Sprouty by EGFR in cytosol
event
IMR:0000081
http://purl.org/obo/owl/IMR#IMR_0000081
IMR:0002072
http://purl.org/obo/owl/IMR#IMR_0002072
Binding of Sprouty and cbl in cytosol
event
IMR:0000356
http://purl.org/obo/owl/IMR#IMR_0000356
IMR:0002072
http://purl.org/obo/owl/IMR#IMR_0002072
Proteasome degradation of Sprouty in cytosol
event
IMR:0002072
http://purl.org/obo/owl/IMR#IMR_0002072
Binding of Sprouty and Grb2 in cytosol
event
IMR:0002072
http://purl.org/obo/owl/IMR#IMR_0002072
IMR:0000340
http://purl.org/obo/owl/IMR#IMR_0000340
Eye development
event
The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
GO:0001654
http://purl.org/obo/owl/GO#GO_0001654
GO:0001654
http://purl.org/obo/owl/GO#GO_0001654
Compound eye development
event
GO:0048749
http://purl.org/obo/owl/GO#GO_0048749
insect-type retina development
compound eye development (sensu Endopterygota)
eye development (sensu Endopterygota)
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure.
GO:0048749
http://purl.org/obo/owl/GO#GO_0048749
Vulval development
event
GO:0040025
http://purl.org/obo/owl/GO#GO_0040025
vulval development (sensu Nematoda)
The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
GO:0040025
http://purl.org/obo/owl/GO#GO_0040025
Multicellular organismal development
event
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
GO:0007275
http://purl.org/obo/owl/GO#GO_0007275
GO:0007275
http://purl.org/obo/owl/GO#GO_0007275
Larval development
event
The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of any animal when more or less of a metamorphosis takes place, before the assumption of the mature shape.
GO:0002164
http://purl.org/obo/owl/GO#GO_0002164
GO:0002164
http://purl.org/obo/owl/GO#GO_0002164
Reproductive process in a multicellular organism
event
GO:0048609
http://purl.org/obo/owl/GO#GO_0048609
The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.
GO:0048609
http://purl.org/obo/owl/GO#GO_0048609
organismal reproductive process
Multicellular organism reproduction
event
GO:0032504
http://purl.org/obo/owl/GO#GO_0032504
The biological process by which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
GO:0032504
http://purl.org/obo/owl/GO#GO_0032504
Ovulation
event
The release of a mature ovum/oocyte from an ovary.
GO:0030728
http://purl.org/obo/owl/GO#GO_0030728
GO:0030728
http://purl.org/obo/owl/GO#GO_0030728
Phosphorylation of Smo by PKA in cytosol
event
IMR:0000249
http://purl.org/obo/owl/IMR#IMR_0000249
IMR:0100802
http://purl.org/obo/owl/IMR#IMR_0100802
Phosphorylation of Smo by CK1 in cytosol
event
IMR:0100809
http://purl.org/obo/owl/IMR#IMR_0100809
IMR:0100802
http://purl.org/obo/owl/IMR#IMR_0100802
Translocation of Smo from endosome to plasma membrane
event
IMR:0100802
http://purl.org/obo/owl/IMR#IMR_0100802
Phosphorylation of Smo by GRK2 in cytosol
event
IMR:0002955
http://purl.org/obo/owl/IMR#IMR_0002955
IMR:0100802
http://purl.org/obo/owl/IMR#IMR_0100802
Binding of Smo and beta-arrestin2 in cytosol
event
IMR:0100802
http://purl.org/obo/owl/IMR#IMR_0100802
IMR:0002957
http://purl.org/obo/owl/IMR#IMR_0002957
Translocation into the cilia
event
Translocation of Smo into the cilia
event
IMR:0100802
http://purl.org/obo/owl/IMR#IMR_0100802
Binding of Cos2, Fu, Ci/Gli, PKA, GSK3 and CK1 in cytosol
event
IMR:0000257
http://purl.org/obo/owl/IMR#IMR_0000257
IMR:0001372
http://purl.org/obo/owl/IMR#IMR_0001372
IMR:0100806
http://purl.org/obo/owl/IMR#IMR_0100806
IMR:0100809
http://purl.org/obo/owl/IMR#IMR_0100809
IMR:0100807
http://purl.org/obo/owl/IMR#IMR_0100807
IMR:0000249
http://purl.org/obo/owl/IMR#IMR_0000249
Ubiquitination of Ci/Gli by SCF ubiquitin ligase complex in cytosol
event
IMR:0100470
http://purl.org/obo/owl/IMR#IMR_0100470
IMR:0001372
http://purl.org/obo/owl/IMR#IMR_0001372
Regulation of Hedgehog signaling pathway
event
GO:0008589
http://purl.org/obo/owl/GO#GO_0008589
regulation of smoothened signalling pathway
GO:0008589
http://purl.org/obo/owl/GO#GO_0008589
Any process that modulates the frequency, rate or extent of smoothened signaling.
GO:0008589
http://purl.org/obo/owl/GO#GO_0008589
Negative regulation of Hedgehog signaling pathway
event
negative regulation of smoothened signalling pathway
downregulation of smoothened signaling pathway
down-regulation of smoothened signaling pathway
down regulation of smoothened signaling pathway
Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling.
GO:0045879
http://purl.org/obo/owl/GO#GO_0045879
GO:0045879
http://purl.org/obo/owl/GO#GO_0045879
Binding of Hedgehog and Hip in extracellular
event
IMR:0000004
http://purl.org/obo/owl/IMR#IMR_0000004
IMR:0002945
http://purl.org/obo/owl/IMR#IMR_0002945
Binding of Hedgehog and Ihog/Boi/Cdo/Boc in extracellular
event
IMR:0000004
http://purl.org/obo/owl/IMR#IMR_0000004
IMR:0002933
http://purl.org/obo/owl/IMR#IMR_0002933
Translocation of Smo from plasma membrane to endosome
event
IMR:0100802
http://purl.org/obo/owl/IMR#IMR_0100802
Translocation from plasma membrane to endosome
event
Degradation in lysosome
event
Degradation of Smo in lysosome
event
IMR:0100802
http://purl.org/obo/owl/IMR#IMR_0100802
Dissociation of Cos2:Fu:Ci/Gli and PKA, GSK3, CK1 in cytosol
event
IMR:0100807
http://purl.org/obo/owl/IMR#IMR_0100807
IMR:0100809
http://purl.org/obo/owl/IMR#IMR_0100809
IMR:0001372
http://purl.org/obo/owl/IMR#IMR_0001372
IMR:0100806
http://purl.org/obo/owl/IMR#IMR_0100806
IMR:0000249
http://purl.org/obo/owl/IMR#IMR_0000249
IMR:0000257
http://purl.org/obo/owl/IMR#IMR_0000257
Autophosphorylation of Fu in cytosol
event
IMR:0100806
http://purl.org/obo/owl/IMR#IMR_0100806
Phosphorylation of Cos2 by Fu in cytosol
event
IMR:0100806
http://purl.org/obo/owl/IMR#IMR_0100806
IMR:0100807
http://purl.org/obo/owl/IMR#IMR_0100807
Phosphorylation of Sufu by Fu in cytosol
event
IMR:0003011
http://purl.org/obo/owl/IMR#IMR_0003011
IMR:0100806
http://purl.org/obo/owl/IMR#IMR_0100806
Dissociation of Sufu and Ci/Gli in cytosol
event
IMR:0001372
http://purl.org/obo/owl/IMR#IMR_0001372
IMR:0003011
http://purl.org/obo/owl/IMR#IMR_0003011
Dissociation of Ci/Gli and Smo:Cos2:Fu in cytosol
event
IMR:0100807
http://purl.org/obo/owl/IMR#IMR_0100807
IMR:0100802
http://purl.org/obo/owl/IMR#IMR_0100802
IMR:0100806
http://purl.org/obo/owl/IMR#IMR_0100806
Dissociation of Ci/Gli from Smo:Cos2:Fu:Ci/Gli in cytosol
IMR:0001372
http://purl.org/obo/owl/IMR#IMR_0001372
Binding of Ci/Gli, CBP and Hedgehog target gene promoter in inner space of nucleus
event
IMR:0000426
http://purl.org/obo/owl/IMR#IMR_0000426
IMR:0001372
http://purl.org/obo/owl/IMR#IMR_0001372
IGS:0000029
http://purl.org/obo/owl/IGS#IGS_0000029
Binding of Ci/Gli, CBP and dpp gene promoter in inner space of nucleus
event
IMR:0001981
http://purl.org/obo/owl/IMR#IMR_0001981
IMR:0001372
http://purl.org/obo/owl/IMR#IMR_0001372
IMR:0000426
http://purl.org/obo/owl/IMR#IMR_0000426
IGS:0000029
http://purl.org/obo/owl/IGS#IGS_0000029
Binding of Ci/Gli, CBP and ptc gene promoter in inner space of nucleus
event
IGS:0000029
http://purl.org/obo/owl/IGS#IGS_0000029
IMR:0000141
http://purl.org/obo/owl/IMR#IMR_0000141
IMR:0000426
http://purl.org/obo/owl/IMR#IMR_0000426
IMR:0001372
http://purl.org/obo/owl/IMR#IMR_0001372
Transcription of Gli1 gene in nucleus
event
IMR:0001363
http://purl.org/obo/owl/IMR#IMR_0001363
Binding of Ci/GliR and Hedgehog target gene promoter in inner space of nucleus
event
IGS:0000029
http://purl.org/obo/owl/IGS#IGS_0000029
IMR:0001372
http://purl.org/obo/owl/IMR#IMR_0001372
Gene expression by Ci/Gli
event
IMR:0001372
http://purl.org/obo/owl/IMR#IMR_0001372
Autocleavage and cholesterol modification of Hedgehog in ER
IEV:0002578
IEV:0002577
event
IMR:0000004
http://purl.org/obo/owl/IMR#IMR_0000004
PubMed:12208857
http://purl.org/obo/owl/PubMed#PubMed_12208857
Autocleavage of hedgehog in ER
Cholesterol modification of hedgehog in ER
IMR:0200486
http://purl.org/obo/owl/IMR#IMR_0200486
It is further processed by internal cleavage to generate a 19-kDa N-terminal fragment (N-Hh) and a 25-kDa C-terminal fragment (C-Hh) with the concomitant addition of cholesterol at the C-terminus of N-Hh (N-Hhchol).
PubMed:12208857
http://purl.org/obo/owl/PubMed#PubMed_12208857
Hedgehog cleavage and lipidation
event
MOD:00314
http://purl.org/obo/owl/MOD#MOD_00314
It is further processed by internal cleavage to generate a 19-kDa N-terminal fragment (N-Hh) and a 25-kDa C-terminal fragment (C-Hh) with the concomitant addition of cholesterol at the C-terminus of N-Hh (N-Hhchol).
PubMed:12208857
http://purl.org/obo/owl/PubMed#PubMed_12208857
PubMed:12208857
http://purl.org/obo/owl/PubMed#PubMed_12208857
Gene expression of FGF receptor by ETS1
event
IMR:0000399
http://purl.org/obo/owl/IMR#IMR_0000399
IMR:0000080
http://purl.org/obo/owl/IMR#IMR_0000080
Transcription of FGF receptor gene in nucleus
event
IMR:0000080
http://purl.org/obo/owl/IMR#IMR_0000080
Nuclear export of mRNA (FGF receptor)
event
IMR:0000080
http://purl.org/obo/owl/IMR#IMR_0000080
Translation of FGF receptor gene in cytosol
event
IMR:0000080
http://purl.org/obo/owl/IMR#IMR_0000080
Gene expression of SRF by ETS1
event
IMR:0002996
http://purl.org/obo/owl/IMR#IMR_0002996
IMR:0000399
http://purl.org/obo/owl/IMR#IMR_0000399
Transcription of SRF gene in nucleus
event
IMR:0002996
http://purl.org/obo/owl/IMR#IMR_0002996
Nuclear export of mRNA (SRF)
event
IMR:0002996
http://purl.org/obo/owl/IMR#IMR_0002996
Translation of SRF gene in cytosol
event
IMR:0002996
http://purl.org/obo/owl/IMR#IMR_0002996
Translocation of FGF receptor from cytosol to plasma membrane
event
IMR:0000080
http://purl.org/obo/owl/IMR#IMR_0000080
Mesoderm migration
event
GO:0007509
http://purl.org/obo/owl/GO#GO_0007509
The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism.
GO:0007509
http://purl.org/obo/owl/GO#GO_0007509
Open tracheal system development
event
GO:0007424
http://purl.org/obo/owl/GO#GO_0007424
The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.
GO:0007424
http://purl.org/obo/owl/GO#GO_0007424
Respiratory system development
event
The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange.
GO:0060541
http://purl.org/obo/owl/GO#GO_0060541
GO:0060541
http://purl.org/obo/owl/GO#GO_0060541
Trachea development
event
GO:0060438
http://purl.org/obo/owl/GO#GO_0060438
The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches.
GO:0060438
http://purl.org/obo/owl/GO#GO_0060438
System development
event
GO:0048731
http://purl.org/obo/owl/GO#GO_0048731
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
GO:0048731
http://purl.org/obo/owl/GO#GO_0048731
Anatomical structure development
event
GO:0048856
http://purl.org/obo/owl/GO#GO_0048856
The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
GO:0048856
http://purl.org/obo/owl/GO#GO_0048856
Tissue development
event
histogenesis
GO:0009888
http://purl.org/obo/owl/GO#GO_0009888
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
GO:0009888
http://purl.org/obo/owl/GO#GO_0009888
Reproductive structure development
event
The reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures.
GO:0048608
http://purl.org/obo/owl/GO#GO_0048608
GO:0048608
http://purl.org/obo/owl/GO#GO_0048608
Sex differentiation
event
The establishment of the sex of an organism by physical differentiation.
GO:0007548
http://purl.org/obo/owl/GO#GO_0007548
GO:0007548
http://purl.org/obo/owl/GO#GO_0007548
Reproductive developmental process
event
A developmental process by which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring.
GO:0003006
http://purl.org/obo/owl/GO#GO_0003006
GO:0003006
http://purl.org/obo/owl/GO#GO_0003006
Binding of FGFR and Grb2 in cytosol
event
IMR:0000080
http://purl.org/obo/owl/IMR#IMR_0000080
IMR:0000340
http://purl.org/obo/owl/IMR#IMR_0000340
Negative regulation of FGF receptor signaling pathway
event
Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.
GO:0040037
http://purl.org/obo/owl/GO#GO_0040037
downregulation of fibroblast growth factor receptor signaling pathway
GO:0040037
http://purl.org/obo/owl/GO#GO_0040037
GO:0040037
http://purl.org/obo/owl/GO#GO_0040037
down-regulation of fibroblast growth factor receptor signaling pathway
GO:0040037
http://purl.org/obo/owl/GO#GO_0040037
negative regulation of FGF receptor signalling pathway
GO:0040037
http://purl.org/obo/owl/GO#GO_0040037
down regulation of fibroblast growth factor receptor signaling pathway
GO:0040037
http://purl.org/obo/owl/GO#GO_0040037
negative regulation of FGFR signaling pathway
GO:0040037
http://purl.org/obo/owl/GO#GO_0040037
Dephosphorylation of FGFR by CLR-1 in cytosol
event
IMR:0000080
http://purl.org/obo/owl/IMR#IMR_0000080
IMR:0003010
http://purl.org/obo/owl/IMR#IMR_0003010
BMK cascade
event
GO:0070375
http://purl.org/obo/owl/GO#GO_0070375
A cascade of protein kinase activities, culminating in the phosphorylation and activation of big MAP kinase (BMK1/ERK5), which is a type of mitogen-activated protein (MAP) kinase.
GO:0070375
http://purl.org/obo/owl/GO#GO_0070375
MAPK7 cascade
ERK5 cascade
BMK1 cascade
receptor clustering
event
Grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
GO:0043113
http://purl.org/obo/owl/GO#GO_0043113
GO:0043113
http://purl.org/obo/owl/GO#GO_0043113
Nonribosomal peptide biosynthesis
event
GO:0019184
http://purl.org/obo/owl/GO#GO_0019184
nonribosomal peptide anabolism
The biosynthetic process whereby peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione.
GO:0019184
http://purl.org/obo/owl/GO#GO_0019184
nonribosomal peptide biosynthetic process
nonribosomal peptide formation
nonribosomal peptide synthesis
Neurotransmitter transport
event
The directed movement of a neurotransmitter into, out of, within or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.
GO:0006836
http://purl.org/obo/owl/GO#GO_0006836
GO:0006836
http://purl.org/obo/owl/GO#GO_0006836
Rhythmic process
event
Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism.
GO:0048511
http://purl.org/obo/owl/GO#GO_0048511
GO:0048511
http://purl.org/obo/owl/GO#GO_0048511
Circadian behavior
event
circadian rhythm behavior
GO:0048512
http://purl.org/obo/owl/GO#GO_0048512
The specific actions or reactions of an organism that recur with a regularity of approximately 24 hours.
GO:0048512
http://purl.org/obo/owl/GO#GO_0048512
Receptor recycling mediated signaling
event
Carboxylic acid metabolism
event
The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
GO:0019752
http://purl.org/obo/owl/GO#GO_0019752
GO:0019752
http://purl.org/obo/owl/GO#GO_0019752
carboxylic acid metabolic process
Alcohol metabolism
event
The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
GO:0006066
http://purl.org/obo/owl/GO#GO_0006066
GO:0006066
http://purl.org/obo/owl/GO#GO_0006066
alcohol metabolic process
Amino acid and derivative metabolism
event
GO:0006519
http://purl.org/obo/owl/GO#GO_0006519
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.
GO:0006519
http://purl.org/obo/owl/GO#GO_0006519
cellular amino acid and derivative metabolic process
Amide metabolism
event
The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells.
GO:0043603
http://purl.org/obo/owl/GO#GO_0043603
GO:0043603
http://purl.org/obo/owl/GO#GO_0043603
cellular amide metabolic process
Nucleobase, nucleoside, nucleotide and nucleic acid metabolism
event
The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
GO:0006139
http://purl.org/obo/owl/GO#GO_0006139
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO:0006139
http://purl.org/obo/owl/GO#GO_0006139
CoA biosynthesis
event
coenzyme A biosynthetic process
coenzyme A formation
KEGG:map00770
http://purl.org/obo/owl/KEGG#KEGG_map00770
GO:0015937
http://purl.org/obo/owl/GO#GO_0015937
coenzyme A biosynthesis
coenzyme A synthesis
CoA biosynthesis: The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
GO:0015937
http://purl.org/obo/owl/GO#GO_0015937
coenzyme A anabolism
Phosphorylation of PLC gamma by receptor tyrosine kinase in cytosol
event
IMR:0000285
http://purl.org/obo/owl/IMR#IMR_0000285
IMR:0000063
http://purl.org/obo/owl/IMR#IMR_0000063
Phosphorylation of PLC gamma by tyrosine kinase in cytosol
event
IMR:0000285
http://purl.org/obo/owl/IMR#IMR_0000285
IMR:0000210
http://purl.org/obo/owl/IMR#IMR_0000210
PubMed:10579907
http://purl.org/obo/owl/PubMed#PubMed_10579907
Phosphorylation of PLC gamma1 by PDGF receptor in cytosol
event
IMR:0000732
http://purl.org/obo/owl/IMR#IMR_0000732
IMR:0000068
http://purl.org/obo/owl/IMR#IMR_0000068
Phosphorylation of PLC by tyrosine kinase in cytosol
event
IMR:0000284
http://purl.org/obo/owl/IMR#IMR_0000284
IMR:0000210
http://purl.org/obo/owl/IMR#IMR_0000210
Binding of PLC and tyrosine kinase in cytosol
event
IMR:0000284
http://purl.org/obo/owl/IMR#IMR_0000284
IMR:0000210
http://purl.org/obo/owl/IMR#IMR_0000210
Binding of PDGF receptor_p and PLC gamma1 in cytosol
event
IMR:0000068
http://purl.org/obo/owl/IMR#IMR_0000068
IMR:0000732
http://purl.org/obo/owl/IMR#IMR_0000732
Binding of PLC gamma and tyrosine kinase in cytosol
event
IMR:0000285
http://purl.org/obo/owl/IMR#IMR_0000285
IMR:0000210
http://purl.org/obo/owl/IMR#IMR_0000210
Binding of FGFR and Dof in cytosol
event
IMR:0000080
http://purl.org/obo/owl/IMR#IMR_0000080
IMR:0002990
http://purl.org/obo/owl/IMR#IMR_0002990
Binding of FGFR and adaptor protein in cytosol
event
IMR:0000080
http://purl.org/obo/owl/IMR#IMR_0000080
IMR:0000333
http://purl.org/obo/owl/IMR#IMR_0000333
Phosphorylation of adaptor protein by FGFR in cytosol
event
IMR:0000080
http://purl.org/obo/owl/IMR#IMR_0000080
IMR:0000333
http://purl.org/obo/owl/IMR#IMR_0000333
Phosphorylation of Dof by FGFR in cytosol
event
IMR:0002990
http://purl.org/obo/owl/IMR#IMR_0002990
IMR:0000080
http://purl.org/obo/owl/IMR#IMR_0000080
Binding of Dof and SHP-2 in cytosol
event
IMR:0002990
http://purl.org/obo/owl/IMR#IMR_0002990
IMR:0000276
http://purl.org/obo/owl/IMR#IMR_0000276
Hydrolysis of GTP by small GTPase and GAP in cytosol
event
IMR:0000288
http://purl.org/obo/owl/IMR#IMR_0000288
IMR:0000442
http://purl.org/obo/owl/IMR#IMR_0000442
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Hydrolysis of GTP by trimeric G-protein in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Hydrolysis of GTP by Ras and RasGAP in cytosol
event
IMR:0000290
http://purl.org/obo/owl/IMR#IMR_0000290
IMR:0000443
http://purl.org/obo/owl/IMR#IMR_0000443
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
GDP-GTP exchange of Ras by Sos1 in cytosol
event
IMR:0000290
http://purl.org/obo/owl/IMR#IMR_0000290
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
IMR:0002063
http://purl.org/obo/owl/IMR#IMR_0002063
Dephosphorylation of PDGF receptor by SHP-2 in cytosol
event
IMR:0000276
http://purl.org/obo/owl/IMR#IMR_0000276
IMR:0000068
http://purl.org/obo/owl/IMR#IMR_0000068
Binding of Ras-GTP and Raf1 in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0100355
http://purl.org/obo/owl/IMR#IMR_0100355
IMR:0000290
http://purl.org/obo/owl/IMR#IMR_0000290
Phosphorylation of Sap-1 by ERK1/2_p in inner space of nucleus
event
IMR:0000227
http://purl.org/obo/owl/IMR#IMR_0000227
IMR:0001095
http://purl.org/obo/owl/IMR#IMR_0001095
Binding of Smo:beta-arrestin 2 and Kif3A in cytosol
event
IMR:0003014
http://purl.org/obo/owl/IMR#IMR_0003014
IMR:0002957
http://purl.org/obo/owl/IMR#IMR_0002957
IMR:0100802
http://purl.org/obo/owl/IMR#IMR_0100802
Movement of Ptc1 out of the cilia
event
IMR:0100742
http://purl.org/obo/owl/IMR#IMR_0100742
Translocation out of the cilia
event
Binding of Nck and PAK1 in cytosol
event
IMR:0000343
http://purl.org/obo/owl/IMR#IMR_0000343
IMR:0100356
http://purl.org/obo/owl/IMR#IMR_0100356
GDP-GTP exchange of Cdc42 by RhoGEF6 in cytosol
event
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
IMR:0000699
http://purl.org/obo/owl/IMR#IMR_0000699
UniProt:Q15052
http://purl.org/obo/owl/UniProt#UniProt_Q15052
IMR:0001357
http://purl.org/obo/owl/IMR#IMR_0001357
Binding of PAK1 and RhoGEF6 in cytosol
event
UniProt:Q15052
http://purl.org/obo/owl/UniProt#UniProt_Q15052
IMR:0100356
http://purl.org/obo/owl/IMR#IMR_0100356
2-Oxo-glutaric acid + N2-Succinyl-L-ornithine = L-Glutamic acid + N-Succinyl-L-glutamate 5-semialdehyde( EC:2.6.1.81 )
event
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
KEGG:R04217
http://purl.org/obo/owl/KEGG#KEGG_R04217
IMR:0200013
http://purl.org/obo/owl/IMR#IMR_0200013
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
EC:2.6.1.81
http://purl.org/obo/owl/EC#EC_2.6.1.81
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
IMR:0200369
http://purl.org/obo/owl/IMR#IMR_0200369
Tetrahydrobiopterin + NADP+ = 6-Lactoyl-5,6,7,8-tetrahydropterin + NADPH + H+( EC:1.1.1.153 )
event
KEGG:R01813
http://purl.org/obo/owl/KEGG#KEGG_R01813
EC:1.1.1.153
http://purl.org/obo/owl/EC#EC_1.1.1.153
KEGG:map00790
http://purl.org/obo/owl/KEGG#KEGG_map00790
KEGG:C04244
http://purl.org/obo/owl/KEGG#KEGG_C04244
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200209
http://purl.org/obo/owl/IMR#IMR_0200209
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
6-Lactoyl-5,6,7,8-tetrahydropterin + NADP+ = 6-Pyruvoyltetrahydropterin + NADPH + H+( EC:1.1.1.153 )
event
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
EC:1.1.1.153
http://purl.org/obo/owl/EC#EC_1.1.1.153
KEGG:C04244
http://purl.org/obo/owl/KEGG#KEGG_C04244
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200063
http://purl.org/obo/owl/IMR#IMR_0200063
KEGG:R04285
http://purl.org/obo/owl/KEGG#KEGG_R04285
KEGG:map00790
http://purl.org/obo/owl/KEGG#KEGG_map00790
GTP + H2O = Formamidopyrimidine nucleoside triphosphate( EC:3.5.4.16 )
subsequently IEV:0003845
event
KEGG:R00428
http://purl.org/obo/owl/KEGG#KEGG_R00428
KEGG:C05922
http://purl.org/obo/owl/KEGG#KEGG_C05922
KEGG:map00790
http://purl.org/obo/owl/KEGG#KEGG_map00790
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
EC:3.5.4.16
http://purl.org/obo/owl/EC#EC_3.5.4.16
Formamidopyrimidine nucleoside triphosphate + H2O = 2,5-Diaminopyrimidine nucleoside triphosphate + Formic acid( EC:3.5.4.16 )
subsequently IEV:0003846
event
KEGG:R05046
http://purl.org/obo/owl/KEGG#KEGG_R05046
EC:3.5.4.16
http://purl.org/obo/owl/EC#EC_3.5.4.16
IMR:0200110
http://purl.org/obo/owl/IMR#IMR_0200110
KEGG:map00790
http://purl.org/obo/owl/KEGG#KEGG_map00790
KEGG:C05923
http://purl.org/obo/owl/KEGG#KEGG_C05923
KEGG:C05922
http://purl.org/obo/owl/KEGG#KEGG_C05922
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
2,5-Diaminopyrimidine nucleoside triphosphate = 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine( EC:3.5.4.16 )
subsequently IEV:0003847
event
KEGG:C05923
http://purl.org/obo/owl/KEGG#KEGG_C05923
KEGG:C06148
http://purl.org/obo/owl/KEGG#KEGG_C06148
KEGG:map00790
http://purl.org/obo/owl/KEGG#KEGG_map00790
EC:3.5.4.16
http://purl.org/obo/owl/EC#EC_3.5.4.16
KEGG:R05048
http://purl.org/obo/owl/KEGG#KEGG_R05048
2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate + H2O = 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine( EC:3.5.4.16 )
event
IMR:0200406
http://purl.org/obo/owl/IMR#IMR_0200406
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00790
http://purl.org/obo/owl/KEGG#KEGG_map00790
KEGG:C06148
http://purl.org/obo/owl/KEGG#KEGG_C06148
KEGG:R04639
http://purl.org/obo/owl/KEGG#KEGG_R04639
EC:3.5.4.16
http://purl.org/obo/owl/EC#EC_3.5.4.16
L-Glutamate + Glyoxylic acid = 2-Oxo-glutaric acid + Glycine( EC:2.6.1.44 )
event
EC:2.6.1.44
http://purl.org/obo/owl/EC#EC_2.6.1.44
KEGG:R00372
http://purl.org/obo/owl/KEGG#KEGG_R00372
KEGG:map00260
http://purl.org/obo/owl/KEGG#KEGG_map00260
IMR:0200480
http://purl.org/obo/owl/IMR#IMR_0200480
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
IMR:0200184
http://purl.org/obo/owl/IMR#IMR_0200184
IMR:0100118
http://purl.org/obo/owl/IMR#IMR_0100118
ATP + Propanoic acid = Diphosphate + Propionyladenylate( EC:6.2.1.1 )
subsequently IEV:0003850
event
KEGG:map00640
http://purl.org/obo/owl/KEGG#KEGG_map00640
KEGG:C05983
http://purl.org/obo/owl/KEGG#KEGG_C05983
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
KEGG:R01354
http://purl.org/obo/owl/KEGG#KEGG_R01354
EC:6.2.1.1
http://purl.org/obo/owl/EC#EC_6.2.1.1
IMR:0200081
http://purl.org/obo/owl/IMR#IMR_0200081
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
Propionyladenylate + CoA = AMP + Propanoyl-CoA( EC:6.2.1.1 )
event
KEGG:map00640
http://purl.org/obo/owl/KEGG#KEGG_map00640
KEGG:R00926
http://purl.org/obo/owl/KEGG#KEGG_R00926
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
EC:6.2.1.1
http://purl.org/obo/owl/EC#EC_6.2.1.1
IMR:0200484
http://purl.org/obo/owl/IMR#IMR_0200484
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
KEGG:C05983
http://purl.org/obo/owl/KEGG#KEGG_C05983
Arachidonic acid + O2 = Leukotriene A4 + H2O( EC:1.13.11.34 )
two-step reaction
event
EC:1.13.11.34
http://purl.org/obo/owl/EC#EC_1.13.11.34
IMR:0200212
http://purl.org/obo/owl/IMR#IMR_0200212
IMR:0200461
http://purl.org/obo/owl/IMR#IMR_0200461
KEGG:R08527
http://purl.org/obo/owl/KEGG#KEGG_R08527
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
Arachidonic acid + Reduced acceptor + 2 O2 = Prostaglandin H2 + Acceptor + H2O( EC:1.14.99.1 )
multi-step reaction
event
EC:1.14.99.1
http://purl.org/obo/owl/EC#EC_1.14.99.1
IMR:0200253
http://purl.org/obo/owl/IMR#IMR_0200253
KEGG:R01599
http://purl.org/obo/owl/KEGG#KEGG_R01599
IMR:0200224
http://purl.org/obo/owl/IMR#IMR_0200224
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200300
http://purl.org/obo/owl/IMR#IMR_0200300
IMR:0200212
http://purl.org/obo/owl/IMR#IMR_0200212
ATP + Acetic acid = Pyrophosphate + Acetyl adenylate( EC:6.2.1.1 )
subsequently IEV:0003854
event
EC:6.2.1.1
http://purl.org/obo/owl/EC#EC_6.2.1.1
KEGG:map00620
http://purl.org/obo/owl/KEGG#KEGG_map00620
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
KEGG:R00316
http://purl.org/obo/owl/KEGG#KEGG_R00316
IMR:0200208
http://purl.org/obo/owl/IMR#IMR_0200208
IMR:0200280
http://purl.org/obo/owl/IMR#IMR_0200280
KEGG:C05993
http://purl.org/obo/owl/KEGG#KEGG_C05993
Acetyl adenylate + CoA = AMP + Acetyl-CoA( EC:6.2.1.1 )
event
IMR:0200354
http://purl.org/obo/owl/IMR#IMR_0200354
KEGG:C05993
http://purl.org/obo/owl/KEGG#KEGG_C05993
IMR:0200414
http://purl.org/obo/owl/IMR#IMR_0200414
IMR:0200083
http://purl.org/obo/owl/IMR#IMR_0200083
EC:6.2.1.1
http://purl.org/obo/owl/EC#EC_6.2.1.1
KEGG:R00236
http://purl.org/obo/owl/KEGG#KEGG_R00236
KEGG:map00620
http://purl.org/obo/owl/KEGG#KEGG_map00620
L-Arginine + O2 + NADPH + H+ = N-(omega)-Hydroxyarginine + NADP+ + H2O( EC:1.14.13.39 )
subsequently IEV:0003856
event
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200428
http://purl.org/obo/owl/IMR#IMR_0200428
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
EC:1.14.13.39
http://purl.org/obo/owl/EC#EC_1.14.13.39
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
KEGG:C05933
http://purl.org/obo/owl/KEGG#KEGG_C05933
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
KEGG:R00558
http://purl.org/obo/owl/KEGG#KEGG_R00558
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
NADPH + 2 N-(omega)-Hydroxyarginine + 2 O2 + H+ = NADP+ + 2 Nitric oxide + 2 L-Citrulline + 2 H2O( EC:1.14.13.39 )
event
IMR:0200030
http://purl.org/obo/owl/IMR#IMR_0200030
IMR:0200463
http://purl.org/obo/owl/IMR#IMR_0200463
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
KEGG:C05933
http://purl.org/obo/owl/KEGG#KEGG_C05933
IMR:0200019
http://purl.org/obo/owl/IMR#IMR_0200019
KEGG:R00111
http://purl.org/obo/owl/KEGG#KEGG_R00111
IMR:0100128
http://purl.org/obo/owl/IMR#IMR_0100128
EC:1.14.13.39
http://purl.org/obo/owl/EC#EC_1.14.13.39
IMR:0200217
http://purl.org/obo/owl/IMR#IMR_0200217
IMR:0200067
http://purl.org/obo/owl/IMR#IMR_0200067
L-Glutamine + H2O = L-Glutamate + NH3( EC:6.3.5.5 )
the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor
event
IMR:0100119
http://purl.org/obo/owl/IMR#IMR_0100119
KEGG:map00910
http://purl.org/obo/owl/KEGG#KEGG_map00910
KEGG:R00256
http://purl.org/obo/owl/KEGG#KEGG_R00256
EC:6.3.5.5
http://purl.org/obo/owl/EC#EC_6.3.5.5
KEGG:map00330
http://purl.org/obo/owl/KEGG#KEGG_map00330
KEGG:map00471
http://purl.org/obo/owl/KEGG#KEGG_map00471
IMR:0200448
http://purl.org/obo/owl/IMR#IMR_0200448
KEGG:map00250
http://purl.org/obo/owl/KEGG#KEGG_map00250
IMR:0200357
http://purl.org/obo/owl/IMR#IMR_0200357
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
2 ATP + HCO3- + NH3 = 2 ADP + Orthophosphate + Carbamoyl phosphate( EC:6.3.5.5 )
multi-step reaction
event
IMR:0001351
http://purl.org/obo/owl/IMR#IMR_0001351
IMR:0001360
http://purl.org/obo/owl/IMR#IMR_0001360
IMR:0200075
http://purl.org/obo/owl/IMR#IMR_0200075
IMR:0200102
http://purl.org/obo/owl/IMR#IMR_0200102
IMR:0200109
http://purl.org/obo/owl/IMR#IMR_0200109
KEGG:C00288
http://purl.org/obo/owl/KEGG#KEGG_C00288
KEGG:R07641
http://purl.org/obo/owl/KEGG#KEGG_R07641
EC:6.3.5.5
http://purl.org/obo/owl/EC#EC_6.3.5.5
Activation of NF-kappaB in cytosol
event
IMR:0000382
http://purl.org/obo/owl/IMR#IMR_0000382
Binding of CDK and cyclin in cytosol
event
IMR:0100596
http://purl.org/obo/owl/IMR#IMR_0100596
IMR:0100606
http://purl.org/obo/owl/IMR#IMR_0100606
Negative regulation of G1 phase
event
Binding of G alpha 12/13-GTP and effector in cytosol
event
IMR:0000324
http://purl.org/obo/owl/IMR#IMR_0000324
IMR:0001354
http://purl.org/obo/owl/IMR#IMR_0001354
Nuclear export of mRNA (INK4 family)
event
IMR:0000447
http://purl.org/obo/owl/IMR#IMR_0000447
Nuclear export of mRNA (Cip/Kip family)
event
IMR:0000446
http://purl.org/obo/owl/IMR#IMR_0000446
Nuclear export of mRNA (CKI)
event
IMR:0000445
http://purl.org/obo/owl/IMR#IMR_0000445
Transcription of CKI by Smad complex in nucleus
event
IMR:0000370
http://purl.org/obo/owl/IMR#IMR_0000370
IMR:0000445
http://purl.org/obo/owl/IMR#IMR_0000445
Translation of CKI in cytosol
event
IMR:0000445
http://purl.org/obo/owl/IMR#IMR_0000445
Binding of ETS1_p and responsive element in inner space of nucleus
event
IGS:0000028
http://purl.org/obo/owl/IGS#IGS_0000028
IMR:0000399
http://purl.org/obo/owl/IMR#IMR_0000399
Phosphorylation of ets domain transcription factor by ERK_p in inner space of nucleus
event
IMR:0000397
http://purl.org/obo/owl/IMR#IMR_0000397
IMR:0000227
http://purl.org/obo/owl/IMR#IMR_0000227
Dissociation of Axin, APC, GSK3beta and beta-catenin in cytosol
event
IMR:0000177
http://purl.org/obo/owl/IMR#IMR_0000177
IMR:0100737
http://purl.org/obo/owl/IMR#IMR_0100737
IMR:0000432
http://purl.org/obo/owl/IMR#IMR_0000432
IMR:0000205
http://purl.org/obo/owl/IMR#IMR_0000205
B cell proliferation
event
The expansion of a B cell population by cell division. Follows B cell activation.
GO:0042100
http://purl.org/obo/owl/GO#GO_0042100
B lymphocyte proliferation
B-cell proliferation
GO:0042100
http://purl.org/obo/owl/GO#GO_0042100
B-lymphocyte proliferation
T cell proliferation
event
GO:0042098
http://purl.org/obo/owl/GO#GO_0042098
T-lymphocyte proliferation
T-cell proliferation
The expansion of a T cell population by cell division. Follows T cell activation.
GO:0042098
http://purl.org/obo/owl/GO#GO_0042098
T lymphocyte proliferation
Th2 cell proliferation
event
Th1 cell proliferation
event
T cell differentiation
event
The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
GO:0030217
http://purl.org/obo/owl/GO#GO_0030217
T-lymphocyte differentiation
GO:0030217
http://purl.org/obo/owl/GO#GO_0030217
T lymphocyte differentiation
T-cell differentiation
Th1 cell differentiation
event
Th2 cell differentiation
event
Cell activation
event
GO:0001775
http://purl.org/obo/owl/GO#GO_0001775
A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.
GO:0001775
http://purl.org/obo/owl/GO#GO_0001775
lymphocyte activation
event
GO:0046649
http://purl.org/obo/owl/GO#GO_0046649
A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.
GO:0046649
http://purl.org/obo/owl/GO#GO_0046649
NK cell activation
event
GO:0030101
http://purl.org/obo/owl/GO#GO_0030101
The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.
GO:0030101
http://purl.org/obo/owl/GO#GO_0030101
natural killer cell activation
Amnioserosa formation
event
Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift.
GO:0007378
http://purl.org/obo/owl/GO#GO_0007378
GO:0007378
http://purl.org/obo/owl/GO#GO_0007378
Ectoderm formation
event
The formation of ectoderm during gastrulation.
GO:0001705
http://purl.org/obo/owl/GO#GO_0001705
GO:0001705
http://purl.org/obo/owl/GO#GO_0001705
Ectoderm development
event
The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.
GO:0007398
http://purl.org/obo/owl/GO#GO_0007398
GO:0007398
http://purl.org/obo/owl/GO#GO_0007398
Complex formation of BMP in ER
event
IMR:0000040
http://purl.org/obo/owl/IMR#IMR_0000040
Translocation of BMP from ER to plasma membrane
event
IMR:0000040
http://purl.org/obo/owl/IMR#IMR_0000040
Binding of Tsg, Chordin and BMP in extracellular
event
IMR:0000040
http://purl.org/obo/owl/IMR#IMR_0000040
IMR:0003020
http://purl.org/obo/owl/IMR#IMR_0003020
IMR:0003022
http://purl.org/obo/owl/IMR#IMR_0003022
Translocation of BMP to the dorsal midline
event
IMR:0000040
http://purl.org/obo/owl/IMR#IMR_0000040
Translocation in extracellular
event
Cleavage of Chordin by Tld in extracellular
event
Autophosphorylation of PAK1 in cytosol
event
IMR:0100356
http://purl.org/obo/owl/IMR#IMR_0100356
Binding of Nck and NIK in cytosol
event
IMR:0000242
http://purl.org/obo/owl/IMR#IMR_0000242
IMR:0000343
http://purl.org/obo/owl/IMR#IMR_0000343
Binding of PAK1 and Cdc42 and conformational change of PAK1 in cytosol
event
IMR:0100356
http://purl.org/obo/owl/IMR#IMR_0100356
IMR:0000699
http://purl.org/obo/owl/IMR#IMR_0000699
Dissociation of PAK1 in cytosol
event
IMR:0100356
http://purl.org/obo/owl/IMR#IMR_0100356
Binding of PDGF receptor and Crk in cytosol
event
IMR:0000335
http://purl.org/obo/owl/IMR#IMR_0000335
IMR:0000068
http://purl.org/obo/owl/IMR#IMR_0000068
Binding of PDGF receptor and PI3K in cytosol
event
IMR:0000068
http://purl.org/obo/owl/IMR#IMR_0000068
IMR:0000265
http://purl.org/obo/owl/IMR#IMR_0000265
Binding of PDGF receptor and SHP-2 in cytosol
event
IMR:0000276
http://purl.org/obo/owl/IMR#IMR_0000276
IMR:0000068
http://purl.org/obo/owl/IMR#IMR_0000068
Binding of PDGF receptor and Nck in cytosol
event
IMR:0000068
http://purl.org/obo/owl/IMR#IMR_0000068
IMR:0000343
http://purl.org/obo/owl/IMR#IMR_0000343
Binding of PDGF receptor and RasGAP in cytosol
event
IMR:0000068
http://purl.org/obo/owl/IMR#IMR_0000068
IMR:0100431
http://purl.org/obo/owl/IMR#IMR_0100431
Binding of PDGF receptor and STAT5 in cytosol
event
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
IMR:0000068
http://purl.org/obo/owl/IMR#IMR_0000068
Dissociation of PDGF receptor and PLC gamma1 in cytosol
event
IMR:0000732
http://purl.org/obo/owl/IMR#IMR_0000732
IMR:0000068
http://purl.org/obo/owl/IMR#IMR_0000068
Dissociation of PDGF receptor and STAT5 in cytosol
event
IMR:0000068
http://purl.org/obo/owl/IMR#IMR_0000068
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
Phosphorylation of Nck by PDGF receptor in cytosol
event
IMR:0000343
http://purl.org/obo/owl/IMR#IMR_0000343
IMR:0000068
http://purl.org/obo/owl/IMR#IMR_0000068
Phosphorylation of Raf1 by PAK1 in cytosol
event
IMR:0100355
http://purl.org/obo/owl/IMR#IMR_0100355
IMR:0100356
http://purl.org/obo/owl/IMR#IMR_0100356
Phosphorylation of STAT5 by PDGF receptor in cytosol
event
IMR:0100733
http://purl.org/obo/owl/IMR#IMR_0100733
IMR:0000068
http://purl.org/obo/owl/IMR#IMR_0000068
Lung development
event
GO:0030324
http://purl.org/obo/owl/GO#GO_0030324
The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
GO:0030324
http://purl.org/obo/owl/GO#GO_0030324
Skin development
event
The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.
GO:0043588
http://purl.org/obo/owl/GO#GO_0043588
GO:0043588
http://purl.org/obo/owl/GO#GO_0043588
Male gonad development
event
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
GO:0008584
http://purl.org/obo/owl/GO#GO_0008584
GO:0008584
http://purl.org/obo/owl/GO#GO_0008584
chemotaxis
event
GO:0006935
http://purl.org/obo/owl/GO#GO_0006935
taxis in response to chemical stimulus
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
GO:0006935
http://purl.org/obo/owl/GO#GO_0006935
mitosis
event
A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
GO:0007067
http://purl.org/obo/owl/GO#GO_0007067
GO:0007067
http://purl.org/obo/owl/GO#GO_0007067
Epithelial cell differentiation
event
GO:0030855
http://purl.org/obo/owl/GO#GO_0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
GO:0030855
http://purl.org/obo/owl/GO#GO_0030855
Endothelial cell differentiation
event
GO:0045446
http://purl.org/obo/owl/GO#GO_0045446
The process in which a mesodermal angioblast acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
GO:0045446
http://purl.org/obo/owl/GO#GO_0045446
Epithelium development
event
The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.
GO:0060429
http://purl.org/obo/owl/GO#GO_0060429
GO:0060429
http://purl.org/obo/owl/GO#GO_0060429
Endothelium development
event
The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. An endothelium is an epithelium that lines an anatomical structure.
GO:0003158
http://purl.org/obo/owl/GO#GO_0003158
GO:0003158
http://purl.org/obo/owl/GO#GO_0003158
Epidermis development
event
GO:0008544
http://purl.org/obo/owl/GO#GO_0008544
The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of a plant or animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
GO:0008544
http://purl.org/obo/owl/GO#GO_0008544
Palate development
event
palatum development
The biological process whose specific outcome is the progression of the palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The palate is the partition that separates the nasal and oral cavities.
GO:0060021
http://purl.org/obo/owl/GO#GO_0060021
GO:0060021
http://purl.org/obo/owl/GO#GO_0060021
Glial cell differentiation
event
The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.
GO:0010001
http://purl.org/obo/owl/GO#GO_0010001
GO:0010001
http://purl.org/obo/owl/GO#GO_0010001
glia cell differentiation
Oligodendrocyte development
event
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
GO:0014003
http://purl.org/obo/owl/GO#GO_0014003
GO:0014003
http://purl.org/obo/owl/GO#GO_0014003
oligodendrocyte cell development
Blood vessel morphogenesis
event
The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
GO:0048514
http://purl.org/obo/owl/GO#GO_0048514
GO:0048514
http://purl.org/obo/owl/GO#GO_0048514
Artery morphogenesis
event
arterial morphogenesis
GO:0048844
http://purl.org/obo/owl/GO#GO_0048844
arteriogenesis
The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs.
GO:0048844
http://purl.org/obo/owl/GO#GO_0048844
angiogenesis
event
blood vessel formation from pre-existing blood vessels
GO:0001525
http://purl.org/obo/owl/GO#GO_0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
GO:0001525
http://purl.org/obo/owl/GO#GO_0001525