part of
type: ObjectProperty
type: TransitiveProperty
has OBO namespace: mouse_pathology.ontology

is a
type: ObjectProperty
has OBO namespace: mouse_pathology.ontology

pathology_ontology
type: Class
has OBO namespace: mouse_pathology.ontology
has definition: pathology_ontology
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

cell and tissue damage
type: Class
subclass of: pathological anatomical entity
has OBO namespace: mouse_pathology.ontology
has definition: The sum of morphological and functional disturbances induced by cell and tissue damage, either from intrinsic gene dysfunction or as a result of external factors.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

gangrene
type: Class
subclass of: necrosis
has OBO namespace: mouse_pathology.ontology
has definition: Extensive necrosis from whatever cause, often following chronic ischemia.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286
has related synonym: Mortification
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

placental abnormality
type: Class
subclass of: organ specific developmental defect
has OBO namespace: mouse_pathology.ontology
has definition: Defect in placental growth, differentiation of circulation; maternal or embryonic component.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

glycogen cell defect
type: Class
subclass of: placental abnormality
has OBO namespace: mouse_pathology.ontology
has definition: Lack of, displacement of, or abnormality in function or growth of the glycogen cells.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

labyrinth zone defect
type: Class
subclass of: placental abnormality
has OBO namespace: mouse_pathology.ontology
has definition: Defect in size, cellular composition, function or organisation of the labyrinthine zone of the placenta.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

placental vascular defect
type: Class
subclass of: placental abnormality
has OBO namespace: mouse_pathology.ontology
has definition: Any defect in the maternal or embryonic placental circulation.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

spongiotrophoblast defect
type: Class
subclass of: placental abnormality
has OBO namespace: mouse_pathology.ontology
has definition: Defect in size, cellular composition, function or organisation of the spongiotrophoblast zone of the placenta.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

circulatory disorder
type: Class
subclass of: pathological anatomical entity
has OBO namespace: mouse_pathology.ontology
has definition: Lesions leading to or consequent on failure of, or atypical movement of, blood throughout the body.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

fluid accumulation
type: Class
subclass of: circulatory disorder
has OBO namespace: mouse_pathology.ontology
has definition: Abnormal accumulation of fluid; blood or lymph.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

congestion
type: Class
subclass of: fluid accumulation
has OBO namespace: mouse_pathology.ontology
has definition: Presence of an abnormal amount of fluid (but especially of blood) in the vessels or passages of a part or organ.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

disseminated intravascular coagulation
type: Class
subclass of: circulatory disorder
comment: Diagnosed by microthrombi in many organs.
has OBO namespace: mouse_pathology.ontology
has related synonym: DIC
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Definition
  label: A syndrome consequent to uncontrolled activation of blood clotting factors leading to disseminated platelet lysis, and fibrin deposition, ultimately leading to bleeding and necrosis as a consequence of inhibition of fibrin polymerisation by degradation products.
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

edema
type: Class
subclass of: fluid accumulation
has OBO namespace: mouse_pathology.ontology
has definition: An accumulation of an excessive amount of watery fluid in cells or intercellular tissues.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

hemorrhagic necrosis
type: Class
subclass of: necrosis
has OBO namespace: mouse_pathology.ontology
has definition: Necrosis associated with local hemorrhage.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

embolus
type: Class
subclass of: circulatory disorder
has OBO namespace: mouse_pathology.ontology
has definition: A plug formed from a variety of materials occluding a vessel or tube.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

air embolism
type: Class
subclass of: embolus
has OBO namespace: mouse_pathology.ontology
has definition: An bubble of air occluding flow through a blood or lymphatic vessel.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

amniotic fluid embolism
type: Class
subclass of: embolus
has OBO namespace: mouse_pathology.ontology
has definition: Occlusion of vessels caused by entry of amniotic fluid, cell and debris into the maternal circulation.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

atrial embolism
type: Class
subclass of: embolus
has OBO namespace: mouse_pathology.ontology
has definition: Occlusion of the outflow tract of the right atrium by a thrombus.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

bone marrow embolism
type: Class
subclass of: embolus
has OBO namespace: mouse_pathology.ontology
has definition: Occlusion of vessels caused by entry of bone marrow, often fatty debris into the circulation. Usually following trauma.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

fat embolism
type: Class
subclass of: embolus
has OBO namespace: mouse_pathology.ontology
has definition: Occlusion of vessels caused by entry of lipid or fatty cells into the circulation. Usually following trauma.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

pulmonary embolism
type: Class
subclass of: embolus
has OBO namespace: mouse_pathology.ontology
has definition: Occlusion of pulmonary vessels by an embolus.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

skin embolism
type: Class
subclass of: embolus
has OBO namespace: mouse_pathology.ontology
has definition: Occlusion of vessels, usually small arterioles in the dermis by various emboli.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

systemic embolism
type: Class
subclass of: embolus
has OBO namespace: mouse_pathology.ontology
has definition: Production of systemic vessel occlusion by emboli released from the left side of the heart, or the aorta.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

hemorrhage and non-specified extravasation
type: Class
subclass of: circulatory disorder
has OBO namespace: mouse_pathology.ontology
has definition: Abnormal release of whole blood or the cellular component from the circulation.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

liquefactive necrosis
type: Class
subclass of: necrosis
has OBO namespace: mouse_pathology.ontology
has definition: Soft or fluid tissue remains of a circumscribed area of necrosis digested by proteolytic enzymes.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

ecchymosis
type: Class
subclass of: hemorrhage and non-specified extravasation
comment: May also be used for any organ, although more generally used with respect to the skin.
has OBO namespace: mouse_pathology.ontology
has definition: A red/purple patch caused by extravasation of blood into the skin. Larger than petechiae.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

hematoma
type: Class
subclass of: hemorrhage and non-specified extravasation
has OBO namespace: mouse_pathology.ontology
has related synonym: Bruise
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: A localised deposition of clotted or partially clotted extravasated blood.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

petechia
type: Class
subclass of: hemorrhage and non-specified extravasation
comment: Usually used with reference to the skin but can be used in the context of other organs.
has OBO namespace: mouse_pathology.ontology
has definition: Small hemorrhagic spots in the skin caused by blood vessel breakdown.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

purpura
type: Class
subclass of: hemorrhage and non-specified extravasation
has OBO namespace: mouse_pathology.ontology
has definition: Purple and variously colored lesions caused by extensive haemorrhage into the skin through ecchymoses/petechia.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

infarct
type: Class
subclass of: circulatory disorder
has OBO namespace: mouse_pathology.ontology
has definition: An area of necrosis resulting from a sudden cessation of arterial or venous blood supply.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

thrombosis
type: Class
subclass of: circulatory disorder
has OBO namespace: mouse_pathology.ontology
has definition: Presence of an occluding or mural thrombus in a blood vessel.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

growth and differentiation defect
type: Class
subclass of: pathological anatomical entity
has OBO namespace: mouse_pathology.ontology
has definition: Defects in growth (changes in proliferation or mass) and differentiation of cells tissues or organs.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

atrophy
type: Class
subclass of: defective growth and differentiation process
has OBO namespace: mouse_pathology.ontology
has definition: A reduction in size of organs or tissues as a result of cell death, loss of cellularity of whatever cause, reduced cellular proliferation or decreased cellular volume.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

intra-epithelial neoplasia
type: Class
subclass of: potentially cancerous lesions
comment: This term has been previously used as a synonym for pre-malignant dysplasia or carcinoma in situ and is now to be preferred.
has OBO namespace: mouse_pathology.ontology
has related synonym: intra-epithelial lesion
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Non-invasive changes characterized by alteration in the size, shape and organization of the cellular components of an epithelial tissue. Do not confuse with developmental dysplasia MPATH:64.
  type: Definition
  has db xref: Journal:_Ward;_J.M._(_2002)_J_Toxicol._Pathol._15;_123-128
    type: DbXref
    has URI: http://purl.org/obo/owl/Journal#Journal__Ward;_J.M._(_2002)_J_Toxicol._Pathol._15;_123-128

epithelial dysplasia
type: Class
subclass of: ObsoleteClass
comment: obsolete due to renaming of preneoplastic dysplasias and Intraepithelial neoplasias Use MPATH:128.
has OBO namespace: mouse_pathology.ontology
has definition: epithelial dysplasia
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

piecemeal necrosis
type: Class
subclass of: necrosis
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Sensu; hepaticobiliary system. Loss and degeneration of hepatocytes at the portal-lobular interface producing a moth-eaten irregular appearance. Piecemeal necrosis is associated with a lymphocytic infiltrate.
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

mild intra-epithelial neoplasia
type: Class
subclass of: intra-epithelial neoplasia
has OBO namespace: mouse_pathology.ontology
has related synonym: IENI
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Mild non-invasive changes in cell morphology and tissue architecture confined to the epithelium alone.
  type: Definition
  has db xref: Journal:_Ward;_J.M._(_2002)_J_Toxicol._Pathol._15;_123-128
    type: DbXref
    has URI: http://purl.org/obo/owl/Journal#Journal__Ward;_J.M._(_2002)_J_Toxicol._Pathol._15;_123-128
has related synonym: mild epithelial dysplasia.
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: low grade intraepithelial lesion
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

moderate intra-epithelial epithelial neoplasia
type: Class
subclass of: intra-epithelial neoplasia
has OBO namespace: mouse_pathology.ontology
has definition: Moderate non-invasive changes in cell morphology and tissue architecture confined to the epithelium alone.
  type: Definition
  has db xref: Journal:_Ward;_J.M._(_2002)_J_Toxicol._Pathol._15;_123-128
    type: DbXref
    has URI: http://purl.org/obo/owl/Journal#Journal__Ward;_J.M._(_2002)_J_Toxicol._Pathol._15;_123-128
has related synonym: IENII
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: high grade intraepithelial lesion
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: moderate epithelial dysplasia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

severe intra-epithelial neoplasia
type: Class
subclass of: intra-epithelial neoplasia
comment: Carcinoma in situ may be used in some systems as a synonym.
has OBO namespace: mouse_pathology.ontology
has related synonym: carcinoma in situ
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: IENIII
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: high grade intra-epithelial lesion
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: severe epithelial dysplasia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Severe non-invasive malignancy associated changes in cell morphology and tissue architecture confined to the epithelium alone.
  type: Definition
  has db xref: Journal:_Ward;_J.M._(_2002)_J_Toxicol._Pathol._15;_123-128
    type: DbXref
    has URI: http://purl.org/obo/owl/Journal#Journal__Ward;_J.M._(_2002)_J_Toxicol._Pathol._15;_123-128

hypoplasia
type: Class
subclass of: defective growth and differentiation process
has OBO namespace: mouse_pathology.ontology
has related synonym: Developmental hypoplasia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Small organ or structure; failure to develop to normal size.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

hyperplasia
type: Class
subclass of: defective growth and differentiation process
has OBO namespace: mouse_pathology.ontology
has definition: An increase in cell numbers in comparison to normal as a consequence of increased cell proliferation. Non -neoplastic process.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

epithelial and stromal hyperplasia
type: Class
subclass of: hyperplastic tissue
has OBO namespace: mouse_pathology.ontology
has definition: Abnormal proliferation of epithelial and stromal cells.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

fibroepithelial polyp
type: Class
subclass of: epithelial hyperplasia
has OBO namespace: mouse_pathology.ontology
has definition: A polypoid outgrowth of both epidermis and dermal fibrovascular tissue.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286
has related synonym: skin tag
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

fibroglandular hyperplasia
type: Class
subclass of: epithelial and stromal hyperplasia
has OBO namespace: mouse_pathology.ontology
has definition: Benign proliferation of glandular epithelium accompanied by proliferation of fibroblastic stroma.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

epithelial hyperplasia
type: Class
subclass of: hyperplastic tissue
has OBO namespace: mouse_pathology.ontology
has definition: Abnormal proliferation of epithelial cells and epithelial components.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

goblet cell hyperplasia
type: Class
subclass of: epithelial hyperplasia
has OBO namespace: mouse_pathology.ontology
has definition: Benign proliferation of goblet cells.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

process of degenerative change
type: Class
subclass of: cell and tissue damage process
has OBO namespace: mouse_pathology.ontology
has definition: A pathological process of loss or degradation of function, or structural integrity, of a tissue, organ or cell.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

hyperplastic polyp
type: Class
subclass of: polyp
has OBO namespace: mouse_pathology.ontology
has definition: A benign polyp, usually in the colon, showing hyperplasia.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

inflammatory polyp
type: Class
subclass of: polyp
has OBO namespace: mouse_pathology.ontology
has related synonym: pseudopolyp
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: A projecting mass of granulation tissue which may become covered by regenerating epithelium.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

intraductal hyperplasia
type: Class
subclass of: epithelial hyperplasia
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Benign hyperplasia of the ducts of the mammary gland. Ducts exhibit more than the usual two layer epithelium (inner cuboidal to columnar cells; outer layer of myoepithelium) without cytological atypia.
  has db xref: PMID:10713680
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_10713680

microglandular hyperplasia
type: Class
subclass of: epithelial hyperplasia
has OBO namespace: mouse_pathology.ontology
has related synonym: microglandular adenosis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Benign proliferation of glandular epithelia, eg. Endocervical glands. Consists of tightly packed glandular or tubular units, which vary in size, lined by a flattened-to-cuboidal epithelium.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

myoepithelial hyperplasia
type: Class
subclass of: epithelial hyperplasia
has OBO namespace: mouse_pathology.ontology
has definition: Benign proliferation of glandular myoepithelial cells.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

fat cell hyperplasia
type: Class
subclass of: hyperplastic tissue
has OBO namespace: mouse_pathology.ontology
has definition: Benign proliferation of adipose tissue.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

histiocytosis
type: Class
subclass of: hyperplastic tissue
has OBO namespace: mouse_pathology.ontology
has definition: Benign proliferation of histiocytes.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

lymphoid hyperplasia
type: Class
subclass of: hyperplastic tissue
has OBO namespace: mouse_pathology.ontology
has related synonym: lymphoid hypertrophy
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Benign enlargement of lymphoid tissues.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

mesothelial hyperplasia
type: Class
subclass of: hyperplastic tissue
has OBO namespace: mouse_pathology.ontology
has definition: Benign proliferation of mesothelial cells lining body cavities presenting as small solid cell clusters or multiple layers with columnar morphology and delicate eosinophilic cytoplasm.
  type: Definition
  has db xref: Pathbase:_Mohr
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Mohr
has related synonym: mesothelioma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

squamous hyperplasia
type: Class
subclass of: hyperplastic tissue
has OBO namespace: mouse_pathology.ontology
has definition: Benign proliferation of epidermal cells with hyperkeratosis. Variable growth pattern, regular to papillary (exophytic squamous cell hyperplasia).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee
has related synonym: epidermal hyperplasia.
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: squamous cell hyperplasia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

general degenerative process
type: Class
subclass of: process of degenerative change
has OBO namespace: mouse_pathology.ontology
has definition: Change of tissue to a lower state of integrity or less functional form, as in heart failure.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

acanthosis
type: Class
subclass of: squamous hyperplasia
has OBO namespace: mouse_pathology.ontology
has definition: Hyperplasia of the Malpighian layer (prickle cell) of the epidermis.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

actinic keratosis
type: Class
subclass of: squamous hyperplasia
subclass of: potentially cancerous lesions
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Discrete, flat or elevated, verrucous, keratotic lesions. Epidermal changes are characterized by acanthosis, parakeratosis, and dyskeratoses. Dysplastic change is present and the keratinocytes vary in size and shape. Associated with UV exposure in humans. Not defined in mice to date.
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

basal cell hyperplasia
type: Class
subclass of: squamous hyperplasia
has OBO namespace: mouse_pathology.ontology
has definition: Benign proliferation of the basal layer cells of the skin.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

hypergranulosis
type: Class
subclass of: squamous hyperplasia
has OBO namespace: mouse_pathology.ontology
has definition: Increased thickness of the granular layer of a stratified squamous epithelium, associated with hyperorthokeratosis.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

hyperkeratosis
type: Class
subclass of: squamous hyperplasia
has OBO namespace: mouse_pathology.ontology
has definition: Thickening of the surface layers (stratum corneum) in the skin or other stratified squamous epithelium. Cf. ortho- and para-keratosis.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee
has related synonym: hyperparakeratosis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: hyperorthokeratosis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: cornification
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

orthokeratosis
type: Class
subclass of: hyperkeratosis
has OBO namespace: mouse_pathology.ontology
has definition: Thickening of the anuclear cell layer limited to the stratum corneum, as in a stratified squamous epithelium.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

parakeratosis
type: Class
subclass of: hyperkeratosis
has OBO namespace: mouse_pathology.ontology
has definition: Thickening of the surface cell layer of a stratified squamous epithelium with retention of nuclei in the cells of the stratum corneum.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

pseudoepithelioma/pseudocarcinoma
type: Class
subclass of: squamous hyperplasia
has OBO namespace: mouse_pathology.ontology
has related synonym: pseudocarcinomatous hyperplasia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Benign hyperplasia and down-growth of epidermal cells. Microscopically resembling well-differentiated squamous cell carcinoma.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286
has related synonym: pseudocarcinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: pseudoepitheliomatous hyperplasia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

seborrheic keratosis
type: Class
subclass of: squamous hyperplasia
has OBO namespace: mouse_pathology.ontology
has definition: Superficial, benign, verrucous, often pigmented, greasy lesions consisting of proliferating epidermal cells, resembling basal cells, enclosing cornifying cysts.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286
has related synonym: seborrheic verruca
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Basal cell papilloma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

hypertrophy
type: Class
subclass of: defective growth and differentiation process
has OBO namespace: mouse_pathology.ontology
has definition: Increase in size or mass of a cell, tissue or organ without increase in cell proliferation. Cf. Hyperplasia MPATH: 133.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

myxoid/myxomatous degeneration
type: Class
subclass of: general degenerative process
has OBO namespace: mouse_pathology.ontology
has related synonym: myxomatosis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Mucoid degeneration
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: A conversion of the connective tissues into a gelatinous or mucous substance.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

metaplasia
type: Class
subclass of: defective growth and differentiation process
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Abnormal transformation of an fully differentiated adult cell or tissue of one kind into a differentiated tissue of another kind. An adult instance of developmental transdifferentiation MPATH:85 Traditionally defined as a form of abnormal regeneration in which a type of cell different from that found normally in a given location is produced.
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

cartilaginous metaplasia
type: Class
subclass of: metaplastic tissue
has OBO namespace: mouse_pathology.ontology
has definition: Metaplasia resulting in heterotopic formation of cartilage.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

epithelial metaplasia
type: Class
subclass of: metaplastic tissue
has OBO namespace: mouse_pathology.ontology
has definition: Metaplasia occurring within epithelia.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

apocrine metaplasia
type: Class
subclass of: epithelial metaplasia
has OBO namespace: mouse_pathology.ontology
has definition: Alteration of acinar epithelium of, for example, mammary tissue to resemble apocrine glands.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

gastric metaplasia
type: Class
subclass of: epithelial metaplasia
has OBO namespace: mouse_pathology.ontology
has definition: Appearance of heterotopic gastric epithelium.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

glandular metaplasia
type: Class
subclass of: epithelial metaplasia
has OBO namespace: mouse_pathology.ontology
has definition: Development of heterotopic glandular epithelia.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

goblet cell metaplasia
type: Class
subclass of: epithelial metaplasia
has OBO namespace: mouse_pathology.ontology
has definition: Metaplasia resulting in formation of mucus secreting goblet cells.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

intestinal metaplasia
type: Class
subclass of: epithelial metaplasia
has OBO namespace: mouse_pathology.ontology
has definition: Appearance of heterotopic intestinal epithelium.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

lipomatous metaplasia
type: Class
subclass of: metaplastic tissue
has OBO namespace: mouse_pathology.ontology
has definition: Metaplasia resulting in formation of fat cells.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

nephrogenic metaplasia
type: Class
subclass of: epithelial metaplasia
has OBO namespace: mouse_pathology.ontology
has definition: .A rare benign neoplasm of the mucosa of the urinary bladder or the urethra, consisting of tubular structures resembling those of the nephron.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286
has related synonym: nephrogenic adenoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

subcellular defect
type: Class
subclass of: cell and tissue damage
has OBO namespace: mouse_pathology.ontology
has definition: Defect of a subcellular structure or organelle.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

oncocytic metaplasia
type: Class
subclass of: epithelial metaplasia
comment: An oncocyte is an acidophilic cell containing numerous mitochondria - an oxophil cell.
has OBO namespace: mouse_pathology.ontology
has definition: Appearance of oncocytic cells in for example an epithelium or tumor.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

squamous metaplasia
type: Class
subclass of: epithelial metaplasia
has OBO namespace: mouse_pathology.ontology
has definition: Change of a glandular or mucosal epithelium into squamous epithelium.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

transitional cell metaplasia
type: Class
subclass of: epithelial metaplasia
has OBO namespace: mouse_pathology.ontology
has definition: Metaplastic response of the transitional epithelium, for example in the bladder to give squamous metaplasia and glandular metaplasia for example.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

myeloid metaplasia
type: Class
subclass of: myeloproliferative disease
has OBO namespace: mouse_pathology.ontology
has definition: A progressive disease of the bone marrow where neoplastic bone marrow stem cells lodge and grow at sites outside the bone marrow.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

osseous metaplasia
type: Class
subclass of: metaplastic tissue
has OBO namespace: mouse_pathology.ontology
has broad synonym: ectopic bone
has definition: Metaplasia resulting in formation of bone.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

healing and repair process
type: Class
subclass of: pathological process
has OBO namespace: mouse_pathology.ontology
has definition: The process, normal or abnormal, of damage repair or wound closure.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

connective tissue replacement
type: Class
subclass of: healing and repair process
has OBO namespace: mouse_pathology.ontology
has definition: Replacement of connective tissue by fibro-fatty deposits and scar tissue.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

angiogenesis
type: Class
subclass of: connective tissue replacement
has OBO namespace: mouse_pathology.ontology
has definition: Aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network by vasculogenesis.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

extracellular matrix deposition
type: Class
subclass of: connective tissue replacement
has OBO namespace: mouse_pathology.ontology
has definition: Abnormal deposition of extracellular matrix proteins or other components.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

fibrin deposition
type: Class
subclass of: connective tissue replacement
has OBO namespace: mouse_pathology.ontology
has definition: Deposition of fibrin.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

cytoskeletal defect
type: Class
subclass of: subcellular defect
has OBO namespace: mouse_pathology.ontology
has definition: Defect in the structure or function of the cytoskeleton.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

fibroblast proliferation
type: Class
subclass of: connective tissue replacement
has OBO namespace: mouse_pathology.ontology
has definition: Abnormal or reactive proliferation of fibroblasts.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

fibrosis
type: Class
subclass of: connective tissue replacement
has OBO namespace: mouse_pathology.ontology
has definition: Reactive formation of fibrous tissue.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

gliosis
type: Class
subclass of: connective tissue replacement
has OBO namespace: mouse_pathology.ontology
has definition: Proliferation of astrocytes in an area of damage in the brain or spinal cord.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

granulation tissue
type: Class
subclass of: healing and repair structure
has OBO namespace: mouse_pathology.ontology
has definition: Newly formed connective (vascular or fibrous)tissue caused by inflammation or healing (repair) processes. Microscopically consists of capillaries fibroblastic cells and inflammatory cells.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

sclerosis
type: Class
subclass of: connective tissue replacement
has OBO namespace: mouse_pathology.ontology
has related synonym: Induration
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Any pathological thickening or hardening of a tissue.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

parenchymal regeneration
type: Class
subclass of: healing and repair process
has OBO namespace: mouse_pathology.ontology
has definition: Post-injury regeneration of the functional tissue parenchyma. Eg. Liver.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

complete parenchymal regeneration
type: Class
subclass of: parenchymal regeneration
has OBO namespace: mouse_pathology.ontology
has definition: Complete healing through parenchymal regeneration - no fibrosis.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

incomplete parenchymal regeneration
type: Class
subclass of: parenchymal regeneration
has OBO namespace: mouse_pathology.ontology
has definition: Incomplete healing usually accompanied by fibrosis.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

immunopathology
type: Class
subclass of: pathological process
has OBO namespace: mouse_pathology.ontology
has definition: Conditions resulting from inappropriate activation or suppression of the immune or inflammatory response.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

hypersensitivity disease
type: Class
subclass of: immunopathology
has OBO namespace: mouse_pathology.ontology
has definition: Immune response resulting in tissue injury.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

endoplasmic reticulum defect
type: Class
subclass of: subcellular defect
has OBO namespace: mouse_pathology.ontology
has definition: Defect in the structure or function of the endoplasmic reticulum.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

type I hypersensitivity
type: Class
subclass of: hypersensitivity disease
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: This is manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized. It is IgE-mediated, and mast cell activation and degranulation are hallmarks.
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

type II hypersensitivity
type: Class
subclass of: hypersensitivity disease
comment: Most often involves IgG and IgM. Complement activation is usually involved.
has OBO namespace: mouse_pathology.ontology
has definition: Caused by an antibody/antigen reaction: antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

type III hypersensitivity
type: Class
subclass of: hypersensitivity disease
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Tissue injury mediated by immune complexes. Generally involves immune complexes formed in the blood via antibodies encountering circulating antigens. Immune complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury.
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

type IV hypersensitivity
type: Class
subclass of: hypersensitivity disease
has OBO namespace: mouse_pathology.ontology
has definition: An antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation. The response is seen at the area of contact.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

immune mediated disease
type: Class
subclass of: immunopathology
has OBO namespace: mouse_pathology.ontology
has definition: Tissue response to inappropriate immune/inflammatory process.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

arthritis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology
has definition: Inflammation of a joint.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

dermatitis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology
has definition: Inflammation of the skin.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

glomerulonephritis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology
has definition: Renal disease characterised by diffuse inflammatory changes in glomeruli not in response to an infectious agent or treatment.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

immune mediated hemolytic anaemia
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology
has definition: An anemic/erythrocytopenic condition resulting from an increased rate of immune mediated erythrocyte destruction.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

immune mediated thrombocytopenia
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology
has definition: A condition resulting from an increased rate of immune mediated platelet destruction.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

cell death
type: Class
subclass of: cell and tissue damage process
has OBO namespace: mouse_pathology.ontology
has definition: Complete and irreversible cessation of metabolic activity.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

golgi defect
type: Class
subclass of: subcellular defect
has OBO namespace: mouse_pathology.ontology
has definition: Defect in the structure or function of the golgi apparatus.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

myositis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology
has definition: Inflammation of a muscle.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Initis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

vasculitis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology
has definition: Inflammation of a blood vessel.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee
has related synonym: angiitis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: arteritis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: lymphangiitis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: phlebitis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

immunodeficiency disease
type: Class
subclass of: immunopathology
has OBO namespace: mouse_pathology.ontology
has definition: Defective immune response; can be primary due to defect in immune system or secondary/acquired due to disease.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

general immunodeficiency disease
type: Class
subclass of: ObsoleteClass
comment: obsolete. Subsumed into MPATH:202
has OBO namespace: mouse_pathology.ontology
has definition: general immunodeficiency disease
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

chronic/recurrent inflammatory disease
type: Class
subclass of: ObsoleteClass
comment: obsolete. Subsumed into MPATH: 214.
has OBO namespace: mouse_pathology.ontology
has definition: chronic/recurrent inflammatory disease
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

immunodeficiency associated infection
type: Class
subclass of: ObsoleteClass
has OBO namespace: mouse_pathology.ontology
has definition: Infection with bacteria, viruses or fungi subsequent to immunodeficiency.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

primary immunodeficiency disease
type: Class
subclass of: immunodeficiency disease
has OBO namespace: mouse_pathology.ontology
has definition: Disease due to primary molecular or cellular defect in the immune system or its development.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

immunodeficiency - lymphoid defect
type: Class
subclass of: primary immunodeficiency disease
has OBO namespace: mouse_pathology.ontology
has definition: Primary defect in the lymphoid arm of the immune system.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

immunodeficiency - myeloid/phagocytic defect
type: Class
subclass of: primary immunodeficiency disease
has OBO namespace: mouse_pathology.ontology
has definition: Primary defect in the myeloid arm of the immune system.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

secondary immunodeficiency disease
type: Class
subclass of: immunodeficiency disease
has OBO namespace: mouse_pathology.ontology
has definition: Defect in the immune system subsequent to external injury, infection, ablation or deficiency.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

lysosomal defect
type: Class
subclass of: subcellular defect
has OBO namespace: mouse_pathology.ontology
has definition: Defect in the structure or function of the lysosomes.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

acquired immunodeficiency
type: Class
subclass of: secondary immunodeficiency disease
has OBO namespace: mouse_pathology.ontology
has definition: Defect in the immune system subsequent to external injury, infection or ablation.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

failed transfer of maternal immunoglobulin
type: Class
subclass of: secondary immunodeficiency disease
has OBO namespace: mouse_pathology.ontology
has definition: Defect in the immune system subsequent to failure to attain passive immunity from maternal transfer of immunoglobulins.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

inflammation
type: Class
subclass of: immune mediated disease
has OBO namespace: mouse_pathology.ontology
has definition: A tissue reaction to an internal or external injury.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

acute inflammation
type: Class
subclass of: inflammation
comment: The five classical signs of inflammation: Rubor, tumor, calor, dolor, functio laesa (Galen 300BC).
has OBO namespace: mouse_pathology.ontology
has definition: Inflammation with a recent onset, characterised histologically by primarily granulocyte infiltration, edema and hyperemia.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

chronic inflammation
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology
has definition: Chronic inflammatory condition characterised by infiltration of primarily lymphocytes.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

granulomatous inflammation
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology
has definition: Nodular inflammatory reaction, containing compactly grouped epithelioid cells, giant cells, and other macrophages. The basic inflammatory unit is termed a granuloma.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

necrotic inflammation
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology
has definition: Acute inflammatory reaction in which the predominant histological change is rapid diffuse necrosis throughout the affected tissue.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

ulcerative inflammation
type: Class
subclass of: ObsoleteClass
comment: Ulcers may be a component or inflammation. Use MPATH: Ulcer
has OBO namespace: mouse_pathology.ontology
has definition: Combination of inflammation, often suppurative or granulomatous, with ulceration.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

neoplasm
type: Class
subclass of: pathological anatomical entity
has OBO namespace: mouse_pathology.ontology
has definition: A tumor resulting from abnormal and uncontrolled autonomous new cell growth (proliferation)that may be benign or malignant.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

adnexal and skin appendage tumor
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: Tumors of the skin, its constituent structures and glands including the mammary gland, apocrine and eccrine glands, hair follicles and associated structures.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

mitochondrial defect
type: Class
subclass of: subcellular defect
has OBO namespace: mouse_pathology.ontology
has definition: Defect in the structure or function of the mitochondria.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

apocrine adenocarcinoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenocarcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Carcinoma of the glandular epithelium of apocrine glands (M-8401/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

apocrine adenoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology
has definition: Benign neoplasm of the epithelium of apocrine glands (M-8401/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

ceruminous adenocarcinoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenocarcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Malignant carcinoma of the ceruminous gland (M-8420/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

ceruminous adenoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology
has definition: Benign adenomatous neoplasia of the ceruminous glands of the external auditory meatus (M-8420/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

clear cell hidradenoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology
has related synonym: nodular hidradenoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Eccrine acrospiroma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Tumor derived from eccrine sweat glands composed of clear glycogen rich cells. ( M-84020 ).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

eccrine gland adenocarcinoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenocarcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Malignant neoplasm of the eccrine gland (M-8413/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

eccrine gland adenoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology
has definition: Benign neoplasm of the eccrine gland (M-8408/0).
  type: Definition
  has db xref: NULL:Papillary_adenoma
    type: DbXref
    has URI: http://purl.org/obo/owl/NULL#NULL_Papillary_adenoma

eccrine papillary adenoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology
has related synonym: Papillary adenoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Papillary form of eccrine sweat gland adenoma. (M -8408/0).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee
has related synonym: benign neoplasm of the eccrine gland, papillary form
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

papillary hidradenoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology
has definition: Benign apocrine sweat gland tumor (8405/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Hidradenoma papilliferum
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

sebaceous adenocarcinoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenocarcinoma
has OBO namespace: mouse_pathology.ontology
has related synonym: sebaceous carcinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Malignant neoplasm of the sebaceous cells - rare areas of differentiation, severe nuclear atypia (M-8410/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

peroxysomal defect
type: Class
subclass of: subcellular defect
has OBO namespace: mouse_pathology.ontology
has definition: Defect in the structure or function of the peroxysomes.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

sebaceous adenoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology
has definition: Adenoma of sebaceous cells; regular architecture of gland not mantained. Large numbers of immature germinative cells present. Mitoses. (M-8410/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Epithelioma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

syringoma
type: Class
subclass of: adnexal and skin appendage tumor
has OBO namespace: mouse_pathology.ontology
has definition: A benign, often multiple, sometimes eruptive neoplasm of the sweat gland ducts composed of very small round cysts. (M-8407/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

trichoepithelioma
type: Class
subclass of: basaloid follicular neoplasms
has OBO namespace: mouse_pathology.ontology
has related synonym: benign
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Epithelioma adenoides cysticum
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: hair follicle tumor
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Multiple small benign nodules derived from basal cells of hair follicles enclosing small cornified cell containing cysts. (M-8100/0).
  type: Definition
  has db xref: URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models
    type: DbXref
    has URI: http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models

basal cell tumor
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology
has related synonym: basal cell adenoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Benign basal cell tumor
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Well circumscribed tumor of the basal cells of the epidermis. Rare mitotic figures, benign. (M8147/0).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

basal cell carcinoma
type: Class
subclass of: carcinoma
subclass of: basaloid follicular neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Malignant neoplasm of the basal cells of the epidermis with local invasion. (M-8090/3).
  type: Definition
  has db xref: URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models
    type: DbXref
    has URI: http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models

blood vessel tumor
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: Tumor of venous or arterial vessels or capillaries.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

angiofibroma
type: Class
subclass of: blood vessel tumor
has OBO namespace: mouse_pathology.ontology
has definition: .A benign neoplasm of fibrous tissue in which there are multiple large and small dilated vascular channels ( M9160/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Telangiectatic fibroma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

angiokeratoma
type: Class
subclass of: blood vessel tumor
has OBO namespace: mouse_pathology.ontology
has related synonym: telangiectatic wart
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: An intradermal capillary telangiectasis with hyperkeratosis and acanthosis (M-9141/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: keratoangioma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: telangiectasia verrucosa
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

hemangioblastoma
type: Class
subclass of: blood vessel tumor
has OBO namespace: mouse_pathology.ontology
has related synonym: Angioblastoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: A benign neoplasm frequently arising in the cerebellum composed of capillary vessel forming endothelial cells and stromal cells. (M-9161/1).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

hemangioendothelioma
type: Class
subclass of: ObsoleteClass
comment: obsolete Use Hemangioma MPATH: 240
has OBO namespace: mouse_pathology.ontology
has definition: hemangioendothelioma
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

plasma membrane defect
type: Class
subclass of: subcellular defect
has OBO namespace: mouse_pathology.ontology
has definition: Defect in the structure or function of the plasma membrane.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

hemangioma
type: Class
subclass of: blood vessel tumor
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasm derived from endothelial cells. May be of capillary or cavernous type with large vascular channels. (M-9130/0 + M-9120/0 respectively).
  type: Definition
  has db xref: PMID:8569146
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_8569146
has related synonym: Hemangioendothelioma, benign
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Angioendothelioma.
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

hemangiopericytoma
type: Class
subclass of: blood vessel tumor
has OBO namespace: mouse_pathology.ontology
has definition: A vascular, usually benign, neoplasm composed of round and spindle cells derived from the pericytes and surround endothelium-lined vessels. (M-9150/0/1/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee
has related synonym: Pericytoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

hemangiosarcoma
type: Class
subclass of: blood vessel tumor
subclass of: sarcoma
has OBO namespace: mouse_pathology.ontology
has related synonym: Hemangioma malignant
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: hemangioendothelioma malignant.
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Malignant neoplasm derived from pluripotential mesenchymal stem cells or endothelial cells of blood vessels. (M-9120/3).
  type: Definition
  has db xref: PMID:8569146
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_8569146
has related synonym: hemangioendothelioma malignant, angiosarcoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

central nervous system tumor
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasm of the neurones, glia or meninges of the CNS.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

astrocytoma
type: Class
subclass of: glioma
comment: Also see comments in Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.
has OBO namespace: mouse_pathology.ontology
has related synonym: Astrocytic glioma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Glioma derived from astrocytes, both benign and malignant forms (M-9400/3).
  type: Definition
  has db xref: ISBN-13:9783794515530
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN-13#ISBN-13_9783794515530
has related synonym: astroglioma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

choroid plexus carcinoma
type: Class
subclass of: carcinoma
subclass of: tumors of neurepithelial tissue
has OBO namespace: mouse_pathology.ontology
has definition: Malignant neoplasm derived from the epithelial cells of the choroid plexus. (M-9390/3).
  type: Definition
  has db xref: ISBN-13:9783794515530
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN-13#ISBN-13_9783794515530

choroid plexus papilloma
type: Class
subclass of: fibroepithelial tumor
subclass of: tumors of neurepithelial tissue
has OBO namespace: mouse_pathology.ontology
has definition: Benign neoplasm derived from the epithelial cells of the choroid plexus. (M-9390/0).
  type: Definition
  has db xref: ISBN-13:9783794515530
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN-13#ISBN-13_9783794515530

ependymoma
type: Class
subclass of: glioma
comment: Also see general scheme in Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasm derived from the ependymal cells lining the ventricles and aqueduct of the brain and the central canal of the spinal cord. Malignant or benign. (M-9391/3).
  type: Definition
  has db xref: ISBN-13:9783794515530
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN-13#ISBN-13_9783794515530

ependymoma malignant
type: Class
subclass of: ObsoleteClass
comment: obsolete -subsumed into MPATH:247
has OBO namespace: mouse_pathology.ontology
has definition: ependymoma malignant
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

glioma
type: Class
subclass of: tumors of neurepithelial tissue
comment: Also see comments in: Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasm derived from astrocytes and oligodendrocytes. (M-9380/3, M-9440/3).
  type: Definition
  has db xref: ISBN-13:9783794515530
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN-13#ISBN-13_9783794515530

tissue specific degenerative process
type: Class
subclass of: process of degenerative change
has OBO namespace: mouse_pathology.ontology
has definition: Degenerative process characteristic of a particular tissue.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

medulloblastoma
type: Class
subclass of: CNS progenitor tumor
comment: Also see Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasm derived from the primitive neurectodermal cells of the cerebellum. (M-9470/3). May be considered by some authorities a synonym of PNET in the CNS.
  type: Definition
  has db xref: ISBN-13:9783794515530
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN-13#ISBN-13_9783794515530

meningioma
type: Class
subclass of: tumors of the meninges
comment: Benign or malignant neoplasm derived from the meninges. (M-9530/0).
has OBO namespace: mouse_pathology.ontology
has definition: meningioma
  type: Definition
  has db xref: ISBN-13:9783794515530
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN-13#ISBN-13_9783794515530
has related synonym: Sarcoma, meningeal ( sensu malignant tumor)
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

oligodendroglioma
type: Class
subclass of: glioma
comment: Also see Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.
has OBO namespace: mouse_pathology.ontology
has definition: Benign or malignant neoplasm derived form oligodendrocytes (M-9450/3).
  type: Definition
  has db xref: ISBN-13:9783794515530
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN-13#ISBN-13_9783794515530
has related synonym: Glioma, oligodendritic, benign
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: glioma oligodendritic, malignant
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

sub-ependymoma
type: Class
subclass of: glioma
comment: Also see general scheme in Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasm derived from sub-ependymal astrocytes (M-9383/1).
  type: Definition
  has db xref: ISBN-13:9783794515530
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN-13#ISBN-13_9783794515530

complex tumor
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: Tumors showing mutiple histological componants/differentiation.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

adenoacanthoma
type: Class
subclass of: complex tumor
has OBO namespace: mouse_pathology.ontology
has definition: Mixed tumor of glandular epithelia with squamous and glandular diffferentiation. (M-8570/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: adenoid squamous cell carcinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

carcinosarcoma
type: Class
subclass of: complex tumor
subclass of: carcinoma
subclass of: sarcoma
has OBO namespace: mouse_pathology.ontology
has definition: Possible origin from smooth muscle cells or pluripotential embryonic mesenchymal cells. May show up to three cellular componants including carcinoma and sarcoma type appearances. (M-8980/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

craniopharyngioma
type: Class
subclass of: complex tumor
has OBO namespace: mouse_pathology.ontology
has related synonym: pituitary ameloblastoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Pituitary adamantinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Rathke pouch tumor
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: suprasellar cyst
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Erdheim tumor
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: A benign or malignant neoplasm, which may be cystic, developing from the epithelium of Rathke`s pouch and occuring with or close to the pituitary gland. (M-9350/1).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

mesodermal mixed tumor
type: Class
subclass of: complex tumor
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasm showing multiple phases, derived from mesoderm (M-8951/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

mucoepidermoid carcinoma
type: Class
subclass of: complex tumor
has OBO namespace: mouse_pathology.ontology
has definition: Most commonly a salivary gland carcinoma of low grade malignancy composed of mucous, epidermoid, and intermediate cells. (M-8430/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

alopecia
type: Class
subclass of: tissue specific degenerative process
has OBO namespace: mouse_pathology.ontology
has definition: Absence of hair or loss of hair.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

mullerian mixed tumor
type: Class
subclass of: complex tumor
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasm usually of the uterus or adnexae containing carcinomatous and sarcomatous elements, sometimes with third or fourth components. (M-8950/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

nephroblastoma
type: Class
subclass of: complex tumor
has OBO namespace: mouse_pathology.ontology
has definition: Embryonal tumor thought to be derived from metanephric blastema. Mono, bi or triphasic, sometimes with heterotypic differentiation. (M-8960/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee
has related synonym: nephroma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

pulmonary blastoma
type: Class
subclass of: complex tumor
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: A biphasic tumor containing a primitive epithelial component, that may resemble well-differentiated fetal adenocarcinoma and a primitive mesenchymal stroma, which occasionally has foci of osteosarcoma, chondrosarcoma or rhadomyosarcoma. (M-8972/3).
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

rhabdoid sarcoma
type: Class
subclass of: complex tumor
subclass of: sarcoma
has OBO namespace: mouse_pathology.ontology
has definition: Sarcomatous tumors, presenting a wide histological, ultrastructural, and immunocytochemical spectrum. M-8963/3.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Malignant rhabdoid tumor
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

fibroepithelial tumor
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: Tumors with epithelial invaginations/linings and a fibrillary and fibrocytic stroma. (M-9000 - M-9030).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

adenofibroma
type: Class
subclass of: fibroepithelial tumor
has OBO namespace: mouse_pathology.ontology
has definition: A benign neoplasm composed of glandular and fibrous tissues, predominantly glandular. (M-9013/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: papillary adenofibroma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Cystadenofibroma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

fibroadenoma
type: Class
subclass of: fibroepithelial tumor
has OBO namespace: mouse_pathology.ontology
has definition: A benign neoplasm derived from glandular epithelium, in which there is a abundant stroma of proliferating fibroblasts and connective tissue. (M-9010/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

glandular tumor
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasms derived from glandular epithelial cells.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

adenocarcinoma
type: Class
subclass of: glandular tumor
subclass of: carcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Malignant neoplasm of epithelial cells in glandular or glandlike pattern. (M-8140/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

adenocarcinoma in situ
type: Class
subclass of: adenocarcinoma
subclass of: potentially cancerous lesions
has OBO namespace: mouse_pathology.ontology
has definition: A noninvasive abnormal proliferation of glands believed to precede the appearance of invasive adenocarcinoma. (M-8140/2).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

arthrosis
type: Class
subclass of: tissue specific degenerative process
has OBO namespace: mouse_pathology.ontology
has related synonym: osteoarthrosis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Degenerative joint disease
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Changes characterized by erosion of articular cartilage, either primary or secondary to trauma or other conditions. Not primarily an inflammatory process.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

adenoma
type: Class
subclass of: glandular tumor
subclass of: potentially cancerous lesions
has OBO namespace: mouse_pathology.ontology
has definition: A benign epithelial neoplasm in which the tumor cells may form glands or glandlike structures. In different instances this may remain a benign tumor or progress to malignancy.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

adenomatous polyposis coli
type: Class
subclass of: glandular tumor
subclass of: potentially cancerous lesions
has OBO namespace: mouse_pathology.ontology
has definition: Spontaneous intestinal adenoma formation. Polyps increase in number, causing symptoms of chronic colitis and potentially transform into adenocarcinoma. (M-8220/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

bronchioloalveolar adenoma
type: Class
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology
has related synonym: Bronchial adenoma, BA adenoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has db xref: URL:_http://emice.nci.nih.gov/mouse_models/organ_models/lung_models/murinecancer/tumorclass
  type: DbXref
  has URI: _http://emice.nci.nih.gov/mouse_models/organ_models/lung_models/murinecancer/tumorclass
has definition: Benign epithelial neoplasm of the lung. (M-8140/1) 1.2.1.2 in MMHCC classification.
  type: Definition
  has db xref: PMID:15059877
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_15059877
has related synonym: Bronchial adenoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

bronchioloalveolar carcinoma
type: Class
subclass of: adenocarcinoma
subclass of: carcinoma
has OBO namespace: mouse_pathology.ontology
has related synonym: Bronchioloalveolar adenocarcinoma, bronchioalveolar carcinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Malignant epithelial neoplasm of the lung. (M-8250/3) 1.2.3.2, 1.2.3.5 of MMHCC classification.
  type: Definition
  has db xref: PMID:15059877
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_15059877
has related synonym: Bronchioloalveolar adenocarcinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has db xref: URL:_http://emice.nci.nih.gov/mouse_models/organ_models/lung_models/murinecancer/tumorclass
  type: DbXref
  has URI: _http://emice.nci.nih.gov/mouse_models/organ_models/lung_models/murinecancer/tumorclass

clear cell adenocarcinoma
type: Class
subclass of: adenocarcinoma
has OBO namespace: mouse_pathology.ontology
has definition: An adenocarcinoma characterised by the presence of varying combinations of clear and hobnail-shaped tumor cells. (M-8310/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

comedocarcinoma
type: Class
subclass of: glandular tumor
subclass of: carcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Form of carcinoma of the breast or other organ in which plugs of necrotic malignant cells are present in the ducts. (M -8501/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

cystadenocarcinoma
type: Class
subclass of: adenocarcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (M-8440/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

cystadenoma
type: Class
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology
has definition: A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (M-8440/0).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

follicular adenocarcinoma
type: Class
subclass of: adenocarcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Originates in the follicular cells of thyroid follicles. Papillary, solid and follicular forms. (M- 8330/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Follicular carcinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

follicular adenoma
type: Class
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology
has definition: Adenoma derived from the follicular cells of the thyroid follicles. Follicular, paipillary and solid forms. M- 8330/0.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

atherosclerosis
type: Class
subclass of: tissue specific degenerative process
comment: Note that in mouse and rats the initial lesions are mostly in the medial layer while in human they occur in the intima.
has OBO namespace: mouse_pathology.ontology
has definition: Characterised by irregular lipid deposits in the wall of arteries, causing narrowing of their lumens and proceeding eventually to fibrosis and calcification.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

Harderian gland adenoma
type: Class
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology
has definition: Adenoma derived from acinar epithelium of the harderian gland. Papillary, cystic, cystic-papillary and acinar forms.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

Harderian gland carcinoma
type: Class
subclass of: glandular tumor
subclass of: carcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Malignant tumor derived form acinar epithelium of the Harderian gland.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

infiltrating duct carcinoma
type: Class
subclass of: adenocarcinoma
subclass of: carcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Derived from the mammary ductal epithelium and penetrating the stroma (M-8500/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee
has related synonym: Infiltrating ductal adenocarcinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: duct adenocarcinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: ductal carcinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

intraductal carcinoma
type: Class
subclass of: ObsoleteClass
comment: Made obsolete by inclusion in MPATH: 486 Ductal intra-epithelial neoplasia
has OBO namespace: mouse_pathology.ontology
has definition: In situ carcinoma of the mammary ductal epithelium. (M- 8500/2).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Ductal carcinoma in situ
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: intraductal adenocarcinoma, non-infiltrating
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

intraductal papillary carcinoma
type: Class
subclass of: glandular tumor
subclass of: carcinoma
has OBO namespace: mouse_pathology.ontology
has related synonym: Intraductal papillary adenocarcinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Infiltrating tumor with papillary morphology derived from the breast epithelium (M-8503/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

intraductal papilloma
type: Class
subclass of: glandular tumor
subclass of: papilloma
subclass of: Restriction
  on property: part of
  some values from: intraductal papillomatosis
has OBO namespace: mouse_pathology.ontology
has related synonym: Duct adenoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Benign papilloma arising from ductal epithelium (M- 8503/0 ).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: ductal papilloma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

intraductal papillomatosis
type: Class
subclass of: glandular tumor
has OBO namespace: mouse_pathology.ontology
has definition: Diffuse multiple adenomatous papillomas derived from the ductal epithelium of the breast. (M- 8505/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Diffuse intraductal papillomatosis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

islet cell adenoma
type: Class
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology
has related synonym: islet (pancreatic) cell tumor benign
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Usually pancreatic B cell derived tumors mostly producing insulin. (M- 8150/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Adenoma, endocrine pancreas
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: adenomatosis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

islet cell carcinoma
type: Class
subclass of: glandular tumor
subclass of: carcinoma
has OBO namespace: mouse_pathology.ontology
has related synonym: islet cell tumor, malignant
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Adenocarcinoma, endocrine pancreas
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Rare tumor of the islets of Langerhans, most of which produce insulin. (M- 8150/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

lobular carcinoma
type: Class
subclass of: glandular tumor
subclass of: carcinoma
has OBO namespace: mouse_pathology.ontology
has related synonym: Lobular adenocarcinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: lobular infiltrating carcinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: A form of breast adenocarcinoma derived from lobular cells. (M-8520/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

cataract
type: Class
subclass of: cell and tissue damage
has OBO namespace: mouse_pathology.ontology
has definition: Opacity of the lens.
  type: Definition
  has db xref: PMID:9309781
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_9309781

lobular carcinoma in situ
type: Class
subclass of: glandular tumor
subclass of: potentially cancerous lesions
has OBO namespace: mouse_pathology.ontology
has definition: Non-infiltrating form of lobular adenocarcinoma derived from the ductal epithelium. (M-8520/2).
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286
has related synonym: mammary intra-epithelial neoplasia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

medullary carcinoma
type: Class
subclass of: glandular tumor
subclass of: carcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Derived from calcitonin-producing cells (thyroid). In humans a type of carcinoma composed of epithelial elements with considerable lymphoid stroma (breast). Not yet reported in mice. (M-8510/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee
has related synonym: Medullary adenocarcinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

mucinous cystadenocarcinoma
type: Class
subclass of: cystadenocarcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Malignant neoplasm derived from a glandular epithelium, eg. Ovary. Consisting of a solid to cystic mass lined with cuboidal pleomorphic epithelial cells producing a mucinous material. (M- 8470/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

mucinous cystadenoma
type: Class
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology
has definition: A benign neoplasm derived from glandular epithelium, in which cystic accumulations of mucinous retained secretions are formed. (M-8470/0).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

myoepithelioma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology
has definition: Tumor originating in myoepithelial cells of exocrine glandular structures; for example mammary gland, salivary gland and preputial/clitoral glands. (M-8982/0).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee
has related synonym: myoepithelial adenoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

papillary adenocarcinoma
type: Class
subclass of: adenocarcinoma
has OBO namespace: mouse_pathology.ontology
has definition: A malignant neoplasm derived from a glandular epithelium, in which solid tumors show papillary structures projecting onto fibrovascular stroma. (M-8260/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

papillary adenoma
type: Class
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology
has definition: A benign neoplasm derived from a glandular epithelium, in which solid tumors show papillary structures projecting onto fibrovascular stroma. (M-8260/0).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

papillary cystadenocarcinoma
type: Class
subclass of: cystadenocarcinoma
has OBO namespace: mouse_pathology.ontology
has definition: A malignant neoplasm derived from glandular epithelium, in which cysts contain folds or papillary projections into the lumen. (M-8450/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

papillary cystadenoma
type: Class
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology
has definition: A benign neoplasm derived from glandular epithelium, in which cysts contain folds or papillary projections into the lumen. (M-8450/0).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

pinealoma
type: Class
subclass of: glandular tumor
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Originating from differentiated cells of the pineal parenchyma. Not to be confused with human pinealoma (syn: germinoma) non-gonadal germ cell tumors found in the pineal believed to be atypical teratomas. May be benign or malignant. If ectopic teratomas/teratocarcinomas use MP322 or MP321. (M-9360/1).
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

apoptosis
type: Class
subclass of: cell death
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Energy dependent cell death induced by intrinsic genetic or developmental programme, or external stimuli such as addition or withdrawal of cytokines or trophic factors, radiation, chemotherapeutic agents etc. Characterised by cell shrinkage, increases in membrane permeability, endonucleolyis and nuclear fragmentation resulting in the formation of rapidly endocytosed apoptotic bodies.
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee
has related synonym: programmed cell death
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

cystic medial necrosis
type: Class
subclass of: necrosis
has OBO namespace: mouse_pathology.ontology
has definition: Loss of muscle fibers and elastin in the media of the aorta, with accumulation of mucopolysaccharide.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286
has related synonym: Erdheim disease
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: media necrosis aortae idiopathica cystica
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: media necrosis of the aorta
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Mucoid medial degeneration
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

pineoblastoma
type: Class
subclass of: glandular tumor
has OBO namespace: mouse_pathology.ontology
has related synonym: Mixed pineal tumor
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: pineal parenchymal tumor of intermediate differentiation
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Malignant neoplasms which arise from pineoblasts, the primitive pineal stem cells. (M-9362/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee
has related synonym: transitional pineal tumor
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

pineocytoma
type: Class
subclass of: glandular tumor
has OBO namespace: mouse_pathology.ontology
has definition: A tumor arising in the pineal gland that resembles normal pineal parenchyma. (M-9361/1).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

pituicytoma
type: Class
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology
has related synonym: pituitary adenoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Benign tumor derived from the pituicytes ( glial cells of neurohypophysis) (M-8272/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

pseudomyxoma peritonei
type: Class
subclass of: glandular tumor
has OBO namespace: mouse_pathology.ontology
has definition: Tumor characterized by extensive spread of a mucin-secreting neoplasm along the peritoneal surfaces (M-8480/6).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

serous adenocarcinoma
type: Class
subclass of: adenocarcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Adenocarcinoma from a serous gland producing and containing serous proteinaceous secretions (M-8441/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

serous cystadenoma
type: Class
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology
has definition: Ovarian cystadenoma composed of cells similar to tubal epithelium (M-8441/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

signet ring cell carcinoma
type: Class
subclass of: adenocarcinoma
has OBO namespace: mouse_pathology.ontology
has related synonym: Signet ring cell adenocarcinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Adenocarcinoma of signet ring type arising from exocrine cells of the gastric mucosa or enterocytes of intestinal mucosa. (M-8490/3).
  type: Definition
  has db xref: PMID:12612914
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12612914
has related synonym: signet ring cell carcinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

thyroid C-cell adenoma
type: Class
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology
has related synonym: tumor c-cell benign
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Benign neoplasm derived from the calcitonin producing C-cells of the thyroid gland.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Adenoma, parafollicular cell
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

thyroid C-cell carcinoma
type: Class
subclass of: glandular tumor
subclass of: carcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Malignant neoplasm derived from the calcitonin producing C-cells of the thyroid gland. (M-8510/3, M-8345/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Medullary carcinoma, parafollicular cell
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: tumor c-cell malignant
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

gonadal tumor
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: Germ cell and non-germ cell tumors of the testis and ovary.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

emphysema
type: Class
subclass of: tissue specific degenerative process
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Abnormal accumulation of air in the interstitial connective tissue of a structure. Sensu Lung: Pulmonary emphysema; characterised by abnormal increase in the size of air (alveolar) spaces distal to the terminal bronchiole with degenerative changes in their walls and reduction in their number.
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

germ cell tumor
type: Class
subclass of: gonadal tumor
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasms derived from germ cells. May be gonadal or extragonadal and are derived from primordial germ cells.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

dermoid cyst
type: Class
subclass of: complex tumor
subclass of: germ cell tumor
subclass of: carcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Cystic ovarian teratomas with different mature cell types (M-9084/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

dysgerminoma
type: Class
subclass of: germ cell tumor
has OBO namespace: mouse_pathology.ontology
has definition: Undifferentiated germ cell tumor of the ovary composed of solid sheets of large polygonal cells with rim of clear cytoplasm (M-9060/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Seminoma (sensu male)
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

embryonal carcinoma
type: Class
subclass of: germ cell tumor
subclass of: carcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Germ cell derived malignant neoplasm of the testis or ovary, composed of anaplastic cells with indistinct cellular borders and large ovoid, round, or bean-shaped nuclei that may have large nucleoli. (M-9070/3 ).
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

endodermal sinus tumor
type: Class
subclass of: germ cell tumor
subclass of: carcinoma
has OBO namespace: mouse_pathology.ontology
has related synonym: Yolk sac carcinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Germ cell derived tumors resembling parietal or visceral yolk sac endoderm derivatives. Abundant eosinophilic matrix surrounding nests and cords of neoplastic cells. (M-9071-3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

gonadoblastoma
type: Class
subclass of: germ cell tumor
has OBO namespace: mouse_pathology.ontology
has related synonym: Gonocytoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Gonadal neoplasms that consist of aggregates of germ cells and sex cord elements (M-9073/1).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

mixed germ cell tumor
type: Class
subclass of: complex tumor
subclass of: germ cell tumor
has OBO namespace: mouse_pathology.ontology
has related synonym: Mixed teratoma and seminoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Malignant neoplasm of the testis/ovary including various elements of germ cell tumors (M-9085/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

seminoma
type: Class
subclass of: germ cell tumor
has OBO namespace: mouse_pathology.ontology
has related synonym: Germinoma, malignant
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: dysgerminoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Tumor derived from spermatogenic cells resembling spermatogenia or spermatocytes. NOS ( M9061/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: spermatoblastoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: spermatocytoma, malignant.
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

classical seminoma
type: Class
subclass of: seminoma
has OBO namespace: mouse_pathology.ontology
has definition: As MPATH:317, but not spermatocytic (M-9061/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

spermatocytic seminoma
type: Class
subclass of: seminoma
has OBO namespace: mouse_pathology.ontology
has related synonym: Spermatoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Definition
  label: Neoplasm of the testis usually found within the tubule. Some debate as to whether it is of germ cell origin in contrast to classical seminoma. Three types of cells are identified in spermatocytic seminomas: those with small, intermediate, and large nuclei in humans. (M-9063/3).
  has db xref: NULL:Walt;_H.;_Oosterhuis;_J.W._and_Stevens;_L.C._(1993)_Int_J_Androl;_16;_267-271
    type: DbXref
    has URI: http://purl.org/obo/owl/NULL#NULL_Walt;_H.;_Oosterhuis;_J.W._and_Stevens;_L.C._(1993)_Int_J_Androl;_16;_267-271

glaucoma
type: Class
subclass of: tissue specific degenerative process
has OBO namespace: mouse_pathology.ontology
has definition: Increase in the intraocular pressure.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

struma ovarii
type: Class
subclass of: germ cell tumor
subclass of: carcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Rare ovarian tumor, regarded as monodermal teratoma, in which thyroid tissue has surpassed the other elements; occasionally associated with hyperthyroidism (M-9090/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

teratocarcinoma
type: Class
subclass of: complex tumor
subclass of: germ cell tumor
subclass of: carcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Mixed germ cell neoplasm contaning elements of embryonal carcinoma and teratoma (M-9081/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

teratoma
type: Class
subclass of: complex tumor
subclass of: germ cell tumor
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Malignant tumors are highly metatstatic. (M-9080/1).
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

gonadal somatic cell tumor
type: Class
subclass of: gonadal tumor
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasms derived from the non-germ cell derived tissues of the testis and ovary.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

androblastoma
type: Class
subclass of: ObsoleteClass
has OBO namespace: mouse_pathology.ontology
has definition: obsolete use Sertoli cell tumor MPATH: 331.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

fibrothecoma
type: Class
subclass of: ObsoleteClass
has OBO namespace: mouse_pathology.ontology
has definition: obsolete use thecoma MPATH:334.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

granulosa cell tumor
type: Class
subclass of: gonadal somatic cell tumor
has OBO namespace: mouse_pathology.ontology
has definition: . Derived from sex cord stromal cells. In male thought to be Sertoli cells. (M- 8620/1).
  type: Definition
  has db xref: PMID:9789961
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_9789961
has related synonym: Tumor, sex cord stromal, benign, granulosa cell type
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: gynoblastoma (sensu malignant form in ovary)
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

gynandroblastoma
type: Class
subclass of: ObsoleteClass
comment: obsolete Use sertoli-leydig cell tumor MPATH 332
has OBO namespace: mouse_pathology.ontology
has definition: gynandroblastoma
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

leydig cell tumor
type: Class
subclass of: gonadal somatic cell tumor
has OBO namespace: mouse_pathology.ontology
has definition: Tumor derived from Leydig cells (M-8650/1).
  type: Definition
  has db xref: Mahler_M;_Sundberg_JP_(_1997)_Spontaneous_Leydig_cell_tumors_in_inbred_laboratory_mice_Lab_Animal_Science_47:148-52
    type: DbXref
    has URI: http://purl.org/obo/owl/Mahler_M#Mahler_M;_Sundberg_JP_(_1997)_Spontaneous_Leydig_cell_tumors_in_inbred_laboratory_mice_Lab_Animal_Science_47_148-52
has related synonym: Leydig cell adenoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Interstitial cell tumor, benign
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

luteal cell tumor
type: Class
subclass of: gonadal somatic cell tumor
has OBO namespace: mouse_pathology.ontology
has definition: Tumor derived from sex cords composed of highly luteinised cells with extensive pale granular cytoplasm. (M- 8610/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: luteinised granulosa cell tumor, benign. Gonadal sex cord stromal tumor, benign, luteoma type
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Luteoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

intracellular and extracellular accumulation
type: Class
subclass of: cell and tissue damage
has OBO namespace: mouse_pathology.ontology
has definition: Accumulation of substances within, on the surface of or between cells.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

ovarian stromal tumor
type: Class
subclass of: complex tumor
subclass of: gonadal somatic cell tumor
has OBO namespace: mouse_pathology.ontology
has definition: Tumor consists of a mixture of granulosa, luteal thecal, Sertoli and stromal cells. (M-8590/1).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

sertoli cell tumor
type: Class
subclass of: gonadal somatic cell tumor
has OBO namespace: mouse_pathology.ontology
has related synonym: sustentacluar tumor
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: sex cord stromal tumor
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Tumor derived from sex cord/stromal cells; Sertoli cells and can occur in both testis and ovary. (M-8640/1).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee
has related synonym: gonadal stromal tumor
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: arrhenoblastoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Androblastoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

sertoli-leydig cell tumor
type: Class
subclass of: gonadal somatic cell tumor
has OBO namespace: mouse_pathology.ontology
has related synonym: Gynandroblastoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Tumor of the ovary or testis containing granulosa or theca cell elements with a tubular componant of Sertoli cell type and producing simultaneous androgenic and estrogenic effects. (M-8631/0).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

sex cord tumor
type: Class
subclass of: ObsoleteClass
comment: obsolete: Use more specific terms: MPATH: 334, 331, 329, 326
has OBO namespace: mouse_pathology.ontology
has definition: sex cord tumor
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

thecoma
type: Class
subclass of: gonadal somatic cell tumor
has OBO namespace: mouse_pathology.ontology
has related synonym: Fibrothecoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Derived from sex cord stromal cells, spindle shaped cells arranged in whorls or interlacing bundles. (M- 8600/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: theca cell tumor
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

hematopoietic/lymphoid malignancies/disorder
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: Proliferative disorders and malignancies of the lymphoid and non lymphoid haematopoietic lineages.
  type: Definition
  has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
    type: DbXref
    has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2

leukaemia
type: Class
subclass of: ObsoleteClass
comment: obsolete folowing reclassification.
has OBO namespace: mouse_pathology.ontology
has definition: leukaemia
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

erythroid leukaemia
type: Class
subclass of: Non-Lymphoid leukaemias
has OBO namespace: mouse_pathology.ontology
has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
  type: DbXref
  has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has definition: Leukaemia with at least 50% of nucleated erythroid cells infiltrating haematopoietic tissue.
  type: Definition
  has db xref: PMID:12070033
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070033

granulocytic leukaemia
type: Class
subclass of: ObsoleteClass
comment: obsolete following reclassification see: MPATH505
has OBO namespace: mouse_pathology.ontology
has definition: granulocytic leukaemia
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

lymphatic leukaemia
type: Class
subclass of: ObsoleteClass
has OBO namespace: mouse_pathology.ontology
has definition: lymphatic leukaemia
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

amyloid deposition
type: Class
subclass of: intracellular and extracellular accumulation
comment: Any group of chemically diverse proteins that appears microscopically homogeneous, but is composed of linear non-branching aggregated fibrils aranged in sheets when see under the electron microscope.
has OBO namespace: mouse_pathology.ontology
has related synonym: Amyloidosis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Extracellular deposition of amyloid protein.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

megakaryocytic leukaemia
type: Class
subclass of: Non-Lymphoid leukaemias
has OBO namespace: mouse_pathology.ontology
has definition: Leukaemia with at least 50% of megakaryocytic cells infiltrating haematopoietic tissue.
  type: Definition
  has db xref: PMID:12070033
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070033
has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
  type: DbXref
  has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2

myelodysplastic disorder
type: Class
subclass of: myeloid dysplasias
has OBO namespace: mouse_pathology.ontology
has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
  type: DbXref
  has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has definition: Haematopoietic proliferation with evidence of trilineage dysplasia. Less than 20% should be blasts.
  type: Definition
  has db xref: PMID:12070033
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070033

myeloid leukaemia
type: Class
subclass of: Non-Lymphoid leukaemias
has OBO namespace: mouse_pathology.ontology
has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
  type: DbXref
  has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has related synonym: granulocytic leukaemia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Leukaemias of the myeloid lineage.
  type: Definition
  has db xref: PMID:12070033
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070033

lymphoma
type: Class
subclass of: ObsoleteClass
comment: obsolete; divided between subtypes of MPATH516, MPATH535
has OBO namespace: mouse_pathology.ontology
has definition: lymphoma
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

follicle center cell lymphoma
type: Class
subclass of: ObsoleteClass
comment: obsolete; see MPATH 522
has OBO namespace: mouse_pathology.ontology
has definition: follicle center cell lymphoma
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

immunoblastic lymphoma
type: Class
subclass of: ObsoleteClass
comment: obsolete; see MPATH525
has OBO namespace: mouse_pathology.ontology
has definition: immunoblastic lymphoma
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

autoimmune mediated disease
type: Class
subclass of: immune mediated disease
has OBO namespace: mouse_pathology.ontology

small lymphocytic lymphoma
type: Class
subclass of: ObsoleteClass
comment: obsolete; see MPATH520
has OBO namespace: mouse_pathology.ontology
has definition: small lymphocytic lymphoma
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

thymic lymphoma
type: Class
subclass of: ObsoleteClass
comment: obsolete
has OBO namespace: mouse_pathology.ontology
has definition: thymic lymphoma
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

mast cell tumor
type: Class
subclass of: ObsoleteClass
comment: obsolete; see MPATH507
has OBO namespace: mouse_pathology.ontology
has definition: mast cell tumor
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

bile deposition
type: Class
subclass of: pigmentation
has OBO namespace: mouse_pathology.ontology
has definition: Intra- or extracellular deposition of bile pigments and their metabolites.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

mastocytoma
type: Class
subclass of: ObsoleteClass
comment: obsolete. See MPATH507
has OBO namespace: mouse_pathology.ontology
has definition: mastocytoma
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

thymoma
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: A neoplasm in the anterior mediastinum, originating from thymic tissue, usually benign, and frequently encapsulated; occasionally invasive, but metastases are rare; histologically, consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. (M-8580/1).
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

hepatic tumor
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: Tumors of the liver and biliary apparatus.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

hepatocellular adenoma
type: Class
subclass of: adenoma
subclass of: hepatic tumor
has OBO namespace: mouse_pathology.ontology
has related synonym: hepatic adenoma, benign, liver cell tumor, benign
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Benign neoplasm derived from hepatocytes. (M- 8170/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: hepatoma, benign
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: nodule type A
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

cholangiocarcinoma
type: Class
subclass of: hepatic tumor
subclass of: carcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Malignant tumor derived from the bile duct epithelium. (M8160/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

cholangiofibroma
type: Class
subclass of: hepatic tumor
has OBO namespace: mouse_pathology.ontology
has definition: Develops from cholangiofibrosis, fibrosis of the biliary ducts and is only potentially malignant.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

hepatoblastoma
type: Class
subclass of: hepatic tumor
has OBO namespace: mouse_pathology.ontology
has related synonym: tumor, mixed, poorly differentiated
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: embryonal hepatoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Malignant neoplasm of the liver of unknown origin . Liver blastemal cells, neoplastic hepatocytes, oval cells and biliary epithelial cells have been proposed. (M- 8970/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

hepatocellular carcinoma
type: Class
subclass of: hepatic tumor
subclass of: carcinoma
has OBO namespace: mouse_pathology.ontology
has related synonym: carcinoma, trabecular
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: nodule type B
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Malignant tumor derived from hepatocytes. (M- 8170/3).
  type: Definition
  has db xref: DbXref
    label: Book:_Bannasche;_P_and_Zerban;_H._Preneoplastic_and_neoplastic_lesions_of_the_rat_iver._In;_Pathology_of_neoplasia_and_preneoplasia_in_rodents;_P._Bannasch_and_W._Goessner;_Editors._1997._Schattauer;_Stuttgart._p._18-63
    has URI: http://purl.org/obo/owl/Book#Book__Bannasche;_P_and_Zerban;_H._Preneoplastic_and_neoplastic_lesions_of_the_rat_iver._In;_Pathology_of_neoplasia_and_preneoplasia_in_rodents;_P._Bannasch_and_W._Goessner…
has related synonym: hepatoma, malignant
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: carcinoma, trabecular (liver)
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

melanocytic tumor
type: Class
subclass of: adnexal and skin appendage tumor
has OBO namespace: mouse_pathology.ontology
has definition: Tumors derived from melanocytes.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

melanoma
type: Class
subclass of: melanocytic tumor
has OBO namespace: mouse_pathology.ontology
has definition: Tumor of neurectodermal origin, usually melanocytes, showing dense deposition of melanin granules, although amelanotic melanomas have been reported. (M-8720/3).
  type: Definition
  has db xref: DbXref
    label: Book:_Klein-Szanto;_A.J.;_Neoplastic_and_preneoplastic_lesions_of_the_mouse_skin;_in_Pathology_of_neoplasia_and_preneoplasia_in_rodents;_P._Bannasch_and_W._Goessner;_Editors._1997._Schattauer;_Stuttgart._p._1-18
    has URI: http://purl.org/obo/owl/Book#Book__Klein-Szanto;_A.J.;_Neoplastic_and_preneoplastic_lesions_of_the_mouse_skin;_in_Pathology_of_neoplasia_and_preneoplasia_in_rodents;_P._Bannasch_and_W._Goessner;_Edito…
has related synonym: melanosarcoma, malignant melanoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has db xref: URL:_http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models/malignant_melanoma#melanoma_table
  type: DbXref
  has URI: _http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models/malignant_melanoma#melanoma_table
has related synonym: melanosarcoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

calcium deposition
type: Class
subclass of: mineralisation
has OBO namespace: mouse_pathology.ontology
has definition: Intra or extracellular deposition of calcium usually as calcium phosphate.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

melanoma in situ
type: Class
subclass of: melanocytic tumor
subclass of: potentially cancerous lesions
has OBO namespace: mouse_pathology.ontology
has related synonym: level I melanoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Definition
  label: A potentially malignant lesion, melanoma in situ is the first phase of growth of melanoma, in which it is still confined to the epithelial domain (epidermis and adnexa) and has not passed through the basement membrane. (M-8720/2).
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

naevus
type: Class
subclass of: melanocytic tumor
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Local lesion of the skin, often colored by hyperpigmentation or increased vascularity. May be predominantly epidermal, adnexal, melanocytic, vascular, or mesodermal, or a compound overgrowth of these tissues. Not necessarily pre-malignant. (M-8720/0).
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee
has related synonym: mole (sensu melanocytic nevus)
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

mesonephroma
type: Class
subclass of: adenocarcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Benign or malignant neoplasm of the ovary and corpus uteri, thought to originate in mesonephric structures. (M-9110/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee
has related synonym: mesonephric adenocarcinoma, wolffian duct carcinoma, mesonephroid tumor
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

mesonephric tumor
type: Class
subclass of: mesonephroma
has OBO namespace: mouse_pathology.ontology
has related synonym: mesonephroid clear cell adenocarcinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Tumor beleived to be derived from mesonephric remnants. (M-8310/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

mesothelial tumor
type: Class
subclass of: ObsoleteClass
comment: obsolete; subsumed into MPATH365
has OBO namespace: mouse_pathology.ontology
has definition: mesothelial tumor
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

mesothelioma
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Benign or malignant neoplasm derived from the lining cells of the pleura and peritoneum, composed of spindle cells or fibrous tissue which may enclose glandlike spaces lined by cuboidal cells. Epithelioid, fibrous, cystis, papillary, and sarcomatoid variants. (M- 9050/3).
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

neuroendocrine tumor
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasms derived from the neuroendocrine system.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

carcinoid tumor
type: Class
subclass of: neuroendocrine tumor
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Carcinoid tumors are of neuroendocrine origin and derived from primitive stem cells. Found predominantly in the lung and gut they are capable of secreting a large range of substances and have a number of histological subtypes. May resemble but are distinct from small cell lung carcinoma in the lung. (M-8240/3).
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

endocrine adenocarcinoma
type: Class
subclass of: ObsoleteClass
has OBO namespace: mouse_pathology.ontology
has definition: obsolete.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

endocrine adenoma
type: Class
subclass of: ObsoleteClass
has OBO namespace: mouse_pathology.ontology
has definition: endocrine adenoma
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

ceroid deposition
type: Class
subclass of: pigmentation
has OBO namespace: mouse_pathology.ontology
has definition: Intracellular deposition of golden or yellow-brown pigment, acid fast and insoluble in lipid solvents. Believed to be a type of lipofuscin.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

primitive neurectodermal tumor
type: Class
subclass of: CNS progenitor tumor
subclass of: peripheral nervous system tumors
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Primitive neuroectodermal tumors (PNET) are neoplasms derived from primitive neural stem cells either in the CNS or the periphery . These are small-cell, malignant embryonal tumors showing divergent differentiation of variable degree along neuronal, glial, or rarely mesenchymal lines. (M-9473/3, M-9364/3).
  has db xref: ISBN-13:9783794515530
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN-13#ISBN-13_9783794515530
has related synonym: PNET
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

small cell carcinoma
type: Class
subclass of: neuroendocrine tumor
subclass of: carcinoma
comment: see: Meuwissen, R., Linn, S.C., Linnoila, R.I. et al. (2003) Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model. Cancer cell, 4: 181-189. AND Calbo, J., Meuwissen, R., van Montfort, E. et al. (2005) Genotype-phenotype relationships in a mouse model for human small-cell lung cancer. Cold Spring Harbor symposia on quantitative biology, 70: 225-232. AND Meuwissen, R. and Berns, A. (2005) Mouse models for human lung cancer. Genes & development, 19: 643-664.
has OBO namespace: mouse_pathology.ontology
has related synonym: oat cell carcinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has db xref: URL:_http://emice.nci.nih.gov/mouse_models/organ_models/lung_models/murinecancer/tumorclass
  type: DbXref
  has URI: _http://emice.nci.nih.gov/mouse_models/organ_models/lung_models/murinecancer/tumorclass
has definition: Neuroendocrine cell derived anaplastic carcinoma composed of small cells, usually of the lung producing a variety of peptide hormones. (M-8041/3). 1.2.3.4 of MMHCC classification.
  type: Definition
  has db xref: PMID:15059877
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_15059877

tumorlet
type: Class
subclass of: neuroendocrine tumor
has OBO namespace: mouse_pathology.ontology
has definition: Small disseminated foci of atypical bronchiolar epithelial hyperplasia. Benign. (M- 8040/1).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

CNS progenitor tumor
type: Class
subclass of: tumors of neurepithelial tissue
comment: Renamed from neuroepitheliomatous tumor, to reflect primitive origins of this class of tumor.
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasms derived from neuroepithelial precursors.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

esthesioneuroblastoma
type: Class
subclass of: CNS progenitor tumor
has OBO namespace: mouse_pathology.ontology
has definition: A neoplasm of immature, poorly differentiated neuronal cells believed to arise from neuroepithelial precursors in the olfactory epithelium. (M- 9522/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: neuroblastoma, olfactory
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: neuroepithelial carcinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: neuroepithelioma, olfactory
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

ganglioneuroma
type: Class
subclass of: peripheral nervous system tumors
has OBO namespace: mouse_pathology.ontology
has definition: A benign neoplasm composed of mature ganglionic neurons scattered singly or in clumps within a relatively abundant and dense stroma of neurofibrils and collagenous fibers. (M-9490/0).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

neuroblastoma
type: Class
subclass of: CNS progenitor tumor
has OBO namespace: mouse_pathology.ontology
has definition: A malignant neoplasm characterized by immature, poorly differentiated nerve cells of embryonic type. (M-9500/3).
  type: Definition
  has db xref: ISBN-13:9783794515530
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN-13#ISBN-13_9783794515530

pheochromocytoma
type: Class
subclass of: neuroendocrine tumor
has OBO namespace: mouse_pathology.ontology
has definition: A catecholamine-secreting tumor arising from the chromaffin cells of the sympathetic nervous system or adrenal medulla. May be benign or malignant. [See MPATH 398]. (M- 8510/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

retinoblastoma
type: Class
subclass of: CNS progenitor tumor
has OBO namespace: mouse_pathology.ontology
has definition: Malignant juvenile neoplasm of the eye derived from primitive retinal precursor cells. (M- 9510/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

odontogenic tumor
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Neoplasm arising from the tissues of the odontogenic apparatus. These tumors are derived from ectodermal tissue (epithelial tumors) or from mesodermal tissue (connective tissue tumors) or are composed of both components (mixed or composite odontogenic tumors) .
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

copper deposition
type: Class
subclass of: protein deposition
subclass of: mineralisation
has OBO namespace: mouse_pathology.ontology
has definition: Intra and extracellular deposition of copper and copper containing proteins.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

ameloblastic fibroma
type: Class
subclass of: odontogenic tumor
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: A tumor consisting of proliferating strands and clumps of odontogenic epithelium in a highly cellular fibroblastic stroma resembling the dental papilla of developing teeth. The epithelial component are composed of peripheral cuboidal or cylindrical cells enclosing scant stellate cells. (M-9330/0).
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

ameloblastoma
type: Class
subclass of: odontogenic tumor
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Benign odontogenic epithelial neoplasm that histologically mimics the embryonic enamel organ but does not differentiate to the point of forming dental hard tissue. Histologically dominated by epithelial cells in a scant fibroblastic stroma. (M-9310/0).
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

cementifying fibroma
type: Class
subclass of: odontogenic tumor
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Benign neoplasm derived from pluripotential mesenchymal cells or cementoblasts. Well demarcated tumor occurring exclusively in the jaw containing spindle cells which undergo transformation to cuboidal cementoblasts forming multiple cementicle like bodies. ( M-9274/0).
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: ossifying fibroma, cemento-ossifying fibroma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

cementoblastoma
type: Class
subclass of: odontogenic tumor
has OBO namespace: mouse_pathology.ontology
has definition: A neoplasm arising from the periodontal ligament (M-9273/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: True cementoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

cementoma
type: Class
subclass of: odontogenic tumor
has OBO namespace: mouse_pathology.ontology
has definition: Reactive fibro-osseous lesion derived from odotongenic cells in the periodontal ligament (M-9272/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

dentinoma
type: Class
subclass of: odontogenic tumor
has OBO namespace: mouse_pathology.ontology
has definition: Similar lesion to ameloblastic fibroma (MPATH380) , but also showing inductive changes that lead to the formation of dentine (M-9271/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: ameloblastic fibrodentinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

odontogenic tumor
type: Class
subclass of: ObsoleteClass
comment: redundant
has OBO namespace: mouse_pathology.ontology
has definition: odontogenic tumor
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

odontoma
type: Class
subclass of: complex tumor
subclass of: odontogenic tumor
subclass of: hamartoma
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Hamartomatous malformation of odontogenic tissue. It may vary from nondescript masses of dental tissue (complex odontoma) to multiple well-formed teeth (compound odontoma). Cf ameloblastic fibro-odontoma. (M-9280/0).
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

osseous and chondromatous tumor
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasms of bone and cartilage.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

chondroblastoma
type: Class
subclass of: osseous and chondromatous tumor
has OBO namespace: mouse_pathology.ontology
has definition: A benign or malignant neoplasm occuring in the epiphyses of long bones, consisting of highly cellular tissue resembling embryonic cartilage. (M-9230/0, /3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

glycogen deposition
type: Class
subclass of: intracellular and extracellular accumulation
has OBO namespace: mouse_pathology.ontology
has definition: Intracellular deposition of glycogen.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

chondroblastoma, malignant
type: Class
subclass of: ObsoleteClass
comment: Subsumed into MPATH:389
has OBO namespace: mouse_pathology.ontology
has definition: chondroblastoma, malignant
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

chondroma
type: Class
subclass of: osseous and chondromatous tumor
has OBO namespace: mouse_pathology.ontology
has definition: A benign neoplasm derived from mesodermal cells that form cartilage composed of well differentiated hyaline cartilage (M-9220/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

chondrosarcoma
type: Class
subclass of: osseous and chondromatous tumor
has OBO namespace: mouse_pathology.ontology
has definition: Malignant neoplasm derived form pluripotential mesenchymal cells, chondrocytes or chondroblasts. No production of osteoid. (M-9220/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

osteoblastoma
type: Class
subclass of: osseous and chondromatous tumor
has OBO namespace: mouse_pathology.ontology
has related synonym: giant osteoid osteoma, benign osteoblastoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Generally benign osteogenic neoplasm of unknown aetiology. Aggressive form may be confused with osteosarcoma. NOT a syn for osteofibroma. (M-9200/0).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

osteochondroma
type: Class
subclass of: osseous and chondromatous tumor
has OBO namespace: mouse_pathology.ontology
has related synonym: cartilaginous exostosis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Benign bone tumor characterized by hyaline cartilage capped bony growths that project from the surface of the affected bone. (M-9210/0).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

osteofibroma
type: Class
subclass of: osseous and chondromatous tumor
has OBO namespace: mouse_pathology.ontology
has definition: Benign neoplasm derived from pluripotential mesenchymal stem cells or osteoblasts composed of mature nbone trabelculae seperated by a stroma of spindle cells. (M- 9262/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

osteoma
type: Class
subclass of: osseous and chondromatous tumor
has OBO namespace: mouse_pathology.ontology
has related synonym: juxtacortical osteoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: medullary osteoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: cancellous osteoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: osteoid osteoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Benign neoplasm derived from osteoblasts or osteocytes composed of very dense bone with predominantly woven structure. ( M-9180/0).
  type: Definition
  has db xref: DbXref
    label: Book:_Luz;_A_and_Gessner;_W._;_Neoplastic_bone_lesions_of_the_mouse;_in_Pathology_of_neoplasia_and_preneoplasia_in_rodents;_P._Bannasch_and_W._Goessner;_Editors._1997._Schattauer;_Stuttgart._p._142-154
    has URI: http://purl.org/obo/owl/Book#Book__Luz;_A_and_Gessner;_W._;_Neoplastic_bone_lesions_of_the_mouse;_in_Pathology_of_neoplasia_and_preneoplasia_in_rodents;_P._Bannasch_and_W._Goessner;_Editors._1997._Sch…
has related synonym: spongious osteoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: trabecular osteoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: compact osteoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

osteosarcoma
type: Class
subclass of: osseous and chondromatous tumor
has OBO namespace: mouse_pathology.ontology
has definition: Malignant neoplasm derived form mesenchymal stem cells, osteoblasts or osteocytes. Highly invasive and destructive tumor rising in the skeleton with osteoid and immature woven bone. (M-9180/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: osteogenic sarcoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

paragangliomas and glomus tumor
type: Class
subclass of: neuroendocrine tumor
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Generally benign neoplasms of CHIEF cells arising from neuroectodermal tissues, found in various parts of the body. Note that until recently, glomus tumors were believed to be derived from specialised vascular cells, which is incorrect. Paraganglioma is the preferred term.The nomenclature for pheochromocytoma and paraganglioma is inconsistent. The term paraganglioma is used to refer to any extra-adrenal tumor of the paraganglion system or nonfunctional tumor of the paraganglion system. Functional tumors are referred extra-adrenal pheochromocytoma.
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

aortic body tumor
type: Class
subclass of: paragangliomas and glomus tumor
has OBO namespace: mouse_pathology.ontology
has related synonym: aortic body paraganglioma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Paraganglioma arising in the CHIEF cells of the aortic body (M-8691/1).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

necrosis
type: Class
subclass of: cell death
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Morpholological changes after intravital (Pathologic) death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage;characterised by mitochondrial swelling, nuclear pyknosis, karyolysis, swollen and abnormally pale basophilic staining; or karyorrhexis, rupture and fragmentation of the nucleus. Energy independent cf. Apoptosis MPATH 3.
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

hyalinosis
type: Class
subclass of: intracellular and extracellular accumulation
has OBO namespace: mouse_pathology.ontology
has definition: Intracellular deposition of eosinophilic material.
  type: Definition
  has db xref: PMID:_11794381
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID__11794381
has related synonym: Hyaline degeneration, Eosinophilic cytoplasmic change
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

carotid body tumor
type: Class
subclass of: paragangliomas and glomus tumor
has OBO namespace: mouse_pathology.ontology
has related synonym: carotid body paraganglioma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Paraganglioma arising in the CHIEF cells of the carotid body (M-8692/1).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

glomus jugulare tumor
type: Class
subclass of: paragangliomas and glomus tumor
has OBO namespace: mouse_pathology.ontology
has definition: A glomus tumor arising from the chief cells of the paraganglia ( neurectodermal derivatives) , or glomus bodies, located within the wall (adventitia) of the jugular bulb. (8690/1).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

glomus tumor
type: Class
subclass of: ObsoleteClass
comment: obsolete; use paraganglioma M-8711/0) or specific example terms, MPATH399-401.
has OBO namespace: mouse_pathology.ontology
has definition: glomus tumor
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

paraganglioma
type: Class
subclass of: paragangliomas and glomus tumor
has OBO namespace: mouse_pathology.ontology
has definition: A neoplasm composed of derivatives of CHIEF cells usually in single encapsulated nodular masses surrounded with sustentacular cells. ( M- 8711/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: chemodectomas
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: glomus tumor
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: non-chromaffin paragangliomas
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

soft tissue tumor
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasms of the soft and connective tissues.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

chordoma
type: Class
subclass of: soft tissue tumor
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Believed to arise from primitive notochord remnants . Usually occurs along the axial skeleton and is characterised by the presence of bubble cells containing large unstained cytoplasmic vacuoles with central or eccentricc nuclei. Benign but locally invasive. (M-9370/3).
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

dermatofibrosarcoma
type: Class
subclass of: soft tissue tumor
subclass of: sarcoma
has OBO namespace: mouse_pathology.ontology
has definition: Highly recurrent, infiltrative skin tumors of intermediate malignancy derived from fibroblasts/fibrocytes. Human condition dermatofibrosarcoma protruberans (M-8832/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

fibroma
type: Class
subclass of: soft tissue tumor
subclass of: sarcoma
comment: "Soft tissue" qualifier removed by Pathology Panel to increase scope of term.
has OBO namespace: mouse_pathology.ontology
has definition: Benign neoplasm of fibroblasts/fibrocytes with poor/moderate cellularity. (M-8810/0).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

soft tissue fibrosarcoma
type: Class
subclass of: soft tissue tumor
subclass of: sarcoma
has OBO namespace: mouse_pathology.ontology
has definition: Malignant tumor derived from pluripotential mesenchymal stem cells; fibroblasts, fibrocytes (M-8810/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

fibrous histiocytoma
type: Class
subclass of: soft tissue tumor
has OBO namespace: mouse_pathology.ontology
has definition: Benign or maligant tumor derived from pluripotential mesenchymal stem cells showing fibrous and histiocytic differentiation (M-8830/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

iron deposition
type: Class
subclass of: protein deposition
subclass of: mineralisation
has OBO namespace: mouse_pathology.ontology
has definition: Extra- or intra-cellular deposition of iron, iron containing proteins or hemosiderin.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

giant cell tumor of soft tissue
type: Class
subclass of: soft tissue tumor
has OBO namespace: mouse_pathology.ontology
has definition: Malignant or benign tumor of pluripotential mesenchymal stem cells giving rise to large multinucleated cells (M- 9251/1).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee
has related synonym: giant cell fibrous histiocytoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

granular cell tumor/alveolar sarcoma
type: Class
subclass of: ObsoleteClass
comment: obsolete. Use specific terms MPATH: 412 or MPATH: 413
has OBO namespace: mouse_pathology.ontology
has definition: granular cell tumor/alveolar sarcoma
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

alveolar soft part sarcoma
type: Class
subclass of: soft tissue tumor
subclass of: sarcoma
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Malignant tumor of unknown origin though probably myogenic due to expression of MyoD and other myogenic lineage markers. Consists of grouped polygonal tumor cells with granular eosinophilic cytoplasm arranged in an organ-like configuration separated by thin fibrovascular septa. Central areas within these nests of cells become necrotic, and the loss of architecture produces an alveolar appearance. (M-9581/3).
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

granular cell tumor
type: Class
subclass of: myomatous tumor
has OBO namespace: mouse_pathology.ontology
has related synonym: myoblastoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Large polygonal or round cell tumors with abundant acidophilic cytoplasm containing PAS positive granules. Found especially in the uterine cervix. Aetiology unknown. (M-9580/0).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

histiocytic sarcoma
type: Class
subclass of: ObsoleteClass
comment: redundant use MPATH506
has OBO namespace: mouse_pathology.ontology
has definition: histiocytic sarcoma
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

lipomatous tumor
type: Class
subclass of: soft tissue tumor
has OBO namespace: mouse_pathology.ontology
has definition: Tumors derived from the lipogenic lineage or showing predominantly lipomatous differentiation.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

angiomyolipoma
type: Class
subclass of: complex tumor
subclass of: lipomatous tumor
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Benign renal neoplasm composed of fat, vascular, and smooth muscle elements. Associated with tuberous sclerosis in humans. Aetiology unknown, but the combination of elements may reflect a lesion specific pattern of metaplasia. (M-8860/0).
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

lipoma
type: Class
subclass of: lipomatous tumor
has OBO namespace: mouse_pathology.ontology
has definition: Benign neoplasia derived from lipoblasts or lipocytes of white or brown fat. May be angiomatous or hibernomatous. (M- 8850/0).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

liposarcoma
type: Class
subclass of: lipomatous tumor
subclass of: sarcoma
has OBO namespace: mouse_pathology.ontology
has definition: Malignant neoplasms which probably originate in primitive mesenchymal stem cell populations differentiating down a lipomatous pathway. (M-8850/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

lymphatic vessel tumor
type: Class
subclass of: soft tissue tumor
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasms of the lymphatic vessels.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

lipid deposition
type: Class
subclass of: intracellular and extracellular accumulation
has OBO namespace: mouse_pathology.ontology
has definition: Extra or intracellular deposition of lipid.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

lymphangioma
type: Class
subclass of: lymphatic vessel tumor
subclass of: hamartoma
has OBO namespace: mouse_pathology.ontology
has definition: Benign hamartomatous malformation of the lymphatic ducts. Usually found in the skin and may be superficial or deep. (M-9170/0).
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286
has related synonym: Cystic hygroma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

lymphangiomyomatosis
type: Class
subclass of: lymphatic vessel tumor
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Characterized by benign peribronchial, perivascular, and perilymphatic proliferation of atypical smooth muscle resulting in vascular and airway obstruction, cyst formation, and a progressive decline in lung function. (M- 9174/1).
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Lymphangioleiomyomatosis.
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

lymphangiosarcoma
type: Class
subclass of: lymphatic vessel tumor
subclass of: sarcoma
has OBO namespace: mouse_pathology.ontology
has definition: A malignant neoplasm derived from vascular tissue in which the neoplastic cells originate from the endothelial cells of lymphatic vessels. (M-9170/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

myomatous tumor
type: Class
subclass of: soft tissue tumor
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasms derived from myogenic lineages or predominantly composed of cells showing myomatous differentiation.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

intravascular leiomyomatosis
type: Class
subclass of: myomatous tumor
has OBO namespace: mouse_pathology.ontology
has definition: Benign leiomyoma that invades vascular spaces. (M-8890/1).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

leiomyoma
type: Class
subclass of: myomatous tumor
has OBO namespace: mouse_pathology.ontology
has definition: Benign neoplasm derived from smooth muscle cells. (M-8890/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

leiomyosarcoma
type: Class
subclass of: myomatous tumor
subclass of: sarcoma
has OBO namespace: mouse_pathology.ontology
has definition: Malignant tumor derived form pluripotential mesenchymal stem cells or smooth muscle cells. (M- 8890/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

myoblastoma
type: Class
subclass of: ObsoleteClass
comment: obsolete. Syn of granular cell tumor. MPATH 413
has OBO namespace: mouse_pathology.ontology
has definition: myoblastoma
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

rhabdomyosarcoma
type: Class
subclass of: myomatous tumor
subclass of: sarcoma
has OBO namespace: mouse_pathology.ontology
has definition: Malignant tumor of striated muscle or pluripotential mesenchymal stem cells. (M-8900/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

myxomatous tumor
type: Class
subclass of: soft tissue tumor
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasms resembling primitive mesenchymal tissue with a soft mucous matrix.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

lipofuscin deposition
type: Class
subclass of: pigmentation
has OBO namespace: mouse_pathology.ontology
has definition: Intracellular deposition of brown pigment granules probably representing lipid-containing residues of lysosomal digestion. Often age related.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

angiomyxoma
type: Class
subclass of: myxomatous tumor
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Angiomyxoma is a poorly circumscribed, slowly growing lesion composed of spindle-shaped and stellate cells evenly distributed in an abundant myxoid matrix. The lesion contains numerous vessels, often showing some hyalinization of their walls, and occasionally surrounded by a few smooth muscle cells. Immunohistochemically, tumor cells may express desmin and/ or smooth muscle actin (M-8841/1).
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

myxoma
type: Class
subclass of: myxomatous tumor
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: A benign neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix. May show multiple differentiated components. (M-8840/0).
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

myxosarcoma
type: Class
subclass of: myxomatous tumor
subclass of: sarcoma
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: A malignant neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix. (M-8840/3).
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

nerve sheath tumor
type: Class
subclass of: soft tissue tumor
subclass of: peripheral nervous system tumors
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasms of the nerve sheath.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

neurilemmoma
type: Class
subclass of: ObsoleteClass
comment: obsolete. Use schwannoma MPATH438
has OBO namespace: mouse_pathology.ontology
has definition: neurilemmoma
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

neurofibroma
type: Class
subclass of: nerve sheath tumor
has OBO namespace: mouse_pathology.ontology
has definition: Peripheral nerve tumor consisting of chaotic arrays of wavy schwann cell bundles and fibroblasts interspersed within a matrix rich in collagen and mucopolysaccharide. (M9540/0).
  type: Definition
  has db xref: ISBN-13:9783794515530
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN-13#ISBN-13_9783794515530

neurofibromatosis
type: Class
subclass of: nerve sheath tumor
has OBO namespace: mouse_pathology.ontology
has definition: Systemic manifestation of MPATH:435 ( M-9540/1).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

neurofibrosarcoma
type: Class
subclass of: nerve sheath tumor
subclass of: sarcoma
has OBO namespace: mouse_pathology.ontology
has related synonym: malignant peripheral nerve sheath tumor
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Malignant neoplasm derived from Schwann cells. (M-9540/3).
  type: Definition
  has db xref: ISBN-13:9783794515530
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN-13#ISBN-13_9783794515530

schwannoma
type: Class
subclass of: nerve sheath tumor
has OBO namespace: mouse_pathology.ontology
has related synonym: neurilemoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: May be malignant or benign, Schwann cell derived tumor considered to be neurectodermal with some acquired mesenchymal features. (M-9560/0).
  type: Definition
  has db xref: ISBN-13:9783794515530
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN-13#ISBN-13_9783794515530
has related synonym: neurinoma, benign
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

synovial-like tumor
type: Class
subclass of: soft tissue tumor
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasms of synovial origin.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

melanin deposition
type: Class
subclass of: pigmentation
has OBO namespace: mouse_pathology.ontology
has definition: Intra or extracellular deposition of melanin.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

synovial sarcoma
type: Class
subclass of: synovial-like tumor
subclass of: sarcoma
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Malignant neoplasm occurring in close association with tendon sheaths and joint capsules. Biphasic in humans , showing a mixed spindle cell and epithelioid like morphology; this is not seen in rodents to date. (M-9040/3).
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee
has related synonym: Synovial cell sarcoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

synovioma
type: Class
subclass of: ObsoleteClass
comment: Obsolete. Use MPATH:440
has OBO namespace: mouse_pathology.ontology
has definition: synovioma
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

squamous cell tumor
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasms of stratified squamous epithelial cells.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

inverted squamous papilloma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: squamous cell tumor
subclass of: papilloma
has OBO namespace: mouse_pathology.ontology
has related synonym: endophytic papilloma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: invaginated papilloma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Definition
  label: A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells in which proliferating epithelium is invaginated beneath the surface and is more smoothly rounded. (M-8053/0).
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

keratoacanthoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: squamous cell tumor
has OBO namespace: mouse_pathology.ontology
has related synonym: epithelioma, intracutaneous, cornifying
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Definition
  label: Skin type is thought to arise from follicular epithelium of hair follicles; found in other epithelia. Composed of multiple cup shaped cavities filled with lamellated concentrically arranged or homogeneous cornified masses.
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

papilloma
type: Class
subclass of: fibroepithelial tumor
subclass of: potentially cancerous lesions
has OBO namespace: mouse_pathology.ontology
has definition: A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells (M-8050/0).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

squamous cell carcinoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: squamous cell tumor
subclass of: carcinoma
has OBO namespace: mouse_pathology.ontology
has related synonym: carcinoma, epidermoid ( sensu epidermal derived tumors)
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Malignant tumor derived from stratified squamous cells. (M-8070/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

squamous cell carcinoma in situ
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: squamous cell tumor
subclass of: potentially cancerous lesions
has OBO namespace: mouse_pathology.ontology
has related synonym: severe intra-epithelial neoplasia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: IENIII
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Pre-neoplastic intraepithelial lesion of squamous cells (M-8070/2).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

squamous cell papilloma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: squamous cell tumor
subclass of: papilloma
has OBO namespace: mouse_pathology.ontology
has related synonym: Exophytic papilloma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic squamous epithelial cells.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

verrucous carcinoma
type: Class
subclass of: squamous cell tumor
subclass of: carcinoma
has OBO namespace: mouse_pathology.ontology
has definition: A well-differentiated papillary squamous cell carcinoma. (M-8051/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

protein deposition
type: Class
subclass of: intracellular and extracellular accumulation
has OBO namespace: mouse_pathology.ontology
has definition: Non-specified intra or extracellular deposition of protein.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

transitional cell tumor
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasms of transitional epithelia, eg kidney, ureter , bladder , cervix.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

transitional cell carcinoma
type: Class
subclass of: transitional cell tumor
subclass of: carcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Malignant neoplasm of transitional cells (M-8120/3).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

transitional cell carcinoma in situ
type: Class
subclass of: transitional cell tumor
subclass of: potentially cancerous lesions
has OBO namespace: mouse_pathology.ontology
has related synonym: severe intra-epithelial neoplasia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Pre-malignant intra-epithelial neoplasm of transitional cells (M-8120/2).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

transitional cell papilloma
type: Class
subclass of: transitional cell tumor
has OBO namespace: mouse_pathology.ontology
has definition: Pre-malignant lesion of transitional cells, papillomatous form ( M- 8120/1).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

trophoblastic tumor
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: Tumors derived directly from trophoblastic tissue or differentiated from germ cell tumor origins.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

choriocarcinoma
type: Class
subclass of: germ cell tumor
subclass of: trophoblastic tumor
has OBO namespace: mouse_pathology.ontology
has related synonym: Chorioepithelioma, malignant.
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Tumor derived from malignant trophoblastic cells. May be found in the uterus, ovary and testis. May also be derived from teratomas and teratocarcinomas in males. (M-9100/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

hydatidiform mole
type: Class
subclass of: trophoblastic tumor
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Vesicular or cystic tumor with hydropic villi resulting from the proliferation of trophoblast in the absence ( complete) or the presence ( partial) of an embryo. Most complete moles are homozygous androgenetic XX 46.(M-9100/0).
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: gestational trophoblastic disease
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: cystic mole
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

placental site trophoblastic tumor
type: Class
subclass of: trophoblastic tumor
has OBO namespace: mouse_pathology.ontology
has definition: Neoplastic proliferation of intermediate trophoblasts that invades the myometrium at the placental site after a pregnancy. (M-9104/1).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

normal
type: Class
subclass of: pathology_ontology
has OBO namespace: mouse_pathology.ontology
has definition: Normal.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

obsolete
type: Class
subclass of: ObsoleteClass
has OBO namespace: mouse_pathology.ontology
has definition: obsolete
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

uric acid deposition
type: Class
subclass of: intracellular and extracellular accumulation
has OBO namespace: mouse_pathology.ontology
has definition: Extracellular deposition of uric acid crystals.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

nuclear defect
type: Class
subclass of: subcellular defect
has OBO namespace: mouse_pathology.ontology
has definition: Defect in the structure or function of the nuclear membrane or matrix or other component.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

cataract; capsular-epithelial
type: Class
subclass of: cataract
has OBO namespace: mouse_pathology.ontology
has definition: Proliferation of lens epithelium and capsule leading to fibrous metaplasia and anterior subcapsular cataract ( ASC) . Possible developmental origin.
  type: Definition
  has db xref: ISBN:08493086_4X
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_08493086_4X

cataract; nuclear and cortical
type: Class
subclass of: cataract
has OBO namespace: mouse_pathology.ontology
has definition: Nuclear cataract of developmental origin with tendency to progress with age and involve the cortex and capsule.
  type: Definition
  has db xref: ISBN:08493086_4X
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_08493086_4X

cataract; cortical liquefactive
type: Class
subclass of: cataract
has OBO namespace: mouse_pathology.ontology
has definition: Of developmental origins; nucleus and cortex become completely liquefied in post-natal life.
  type: Definition
  has db xref: ISBN:08493086_4X
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_08493086_4X

cataract; lens extrusion
type: Class
subclass of: cataract
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Involves capsular rupture usually of the posterior lens capsule, close to birth or in the first few weeks postpartum. Cortical material spills into the vitreous humor and may be disseminated through the eye.
  has db xref: ISBN:08493086_4X
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_08493086_4X

glaucoma developmental
type: Class
subclass of: glaucoma
has OBO namespace: mouse_pathology.ontology
has definition: Consequent on developmental abnormalities in the trabecular network and Schlemm`s canal in the angle.
  type: Definition
  has db xref: ISBN:08493086_4X
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_08493086_4X

glaucoma; open angle
type: Class
subclass of: glaucoma
has OBO namespace: mouse_pathology.ontology
has definition: Failure of drainage of the eye for unknown reasons.
  type: Definition
  has db xref: ISBN:08493086_4X
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_08493086_4X

glaucoma; angle closure
type: Class
subclass of: glaucoma
has OBO namespace: mouse_pathology.ontology
has definition: Develops when the angle caused by the iris and cornea closes. May occur because of anatomically narrow angles or adhesions.
  type: Definition
  has db xref: ISBN:08493086_4X
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_08493086_4X

pseudocyst
type: Class
subclass of: cell and tissue damage
has OBO namespace: mouse_pathology.ontology
has definition: Formation of extracellular (sensu pancreas) non-epithelial bounded spaces containing accumulated products or substances.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

symmetry defect
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has definition: Any aberration of the normal symmetrical organisation of the body pattern.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

intracellular and extracellular depletion
type: Class
subclass of: cell and tissue damage
has OBO namespace: mouse_pathology.ontology
has definition: Loss or dispersion of specific intra- and extracellular substances.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

left/right axis defect
type: Class
subclass of: symmetry defect
comment: For example as seen in the mutation <situs inversus>.
has OBO namespace: mouse_pathology.ontology
has definition: Left/Right (mediolateral) axis aberration of the normal symmetrical organisation of the body pattern.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

anterior/posterior axis defect
type: Class
subclass of: symmetry defect
has OBO namespace: mouse_pathology.ontology
has definition: Anteroposterior aberration of the normal symmetrical organisation of the body pattern.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

Dorsal/ventral axis defect
type: Class
subclass of: symmetry defect
has OBO namespace: mouse_pathology.ontology
has definition: Dorsoventral aberration of the normal symmetrical organisation of the body pattern.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

developmental cystic dysplasia
type: Class
subclass of: developmental dysplasia
has OBO namespace: mouse_pathology.ontology
has definition: Developmental dysplasia showing epithelial cell bounded cavities.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

ectasia
type: Class
subclass of: dilatation
comment: Often associated with an obstruction.
has OBO namespace: mouse_pathology.ontology
has definition: Dilation of a tubular structure.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

ductal ectasia
type: Class
subclass of: ectasia
has OBO namespace: mouse_pathology.ontology
has definition: Dilation of a ductal structure.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

telangiectasia
type: Class
subclass of: ectasia
has OBO namespace: mouse_pathology.ontology
has definition: A lesion formed by a dilated capillary or terminal artery.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

choristoma
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has definition: Similar to hamartoma, including the mass lesion requirement, but unlike hamartoma, includes heterotopic tissue of an adult or embryonic nature ( topographical and developmental anomaly).
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286
has related synonym: Choristoblastoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

angiogenesis defect
type: Class
subclass of: developmental process abnormalities
has OBO namespace: mouse_pathology.ontology
has definition: Abnormality in developmental angiogenesis.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

vasculogenesis defect
type: Class
subclass of: developmental process abnormalities
has OBO namespace: mouse_pathology.ontology
has definition: Defect in formation of blood vessels by vasculogenesis, proliferation or recruitment of endothelial cells.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

decalcification
type: Class
subclass of: intracellular and extracellular depletion
has OBO namespace: mouse_pathology.ontology
has definition: Process of loss of calcium from normally calcified tissue, usually bone.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

decidual defect
type: Class
subclass of: placental abnormality
has OBO namespace: mouse_pathology.ontology
has definition: Any defect in the formation, architecture, cellular composition or function of the maternal decidua.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

pre-neoplastic lesions
type: Class
subclass of: ObsoleteClass
comment: Obsolete; replaced by potentially pre-cancerous lesions (MPATH 556) as many are actually neoplastic but do not progress to cancer.
has OBO namespace: mouse_pathology.ontology
has definition: Lesions likely to result in progression to frank tumors, which may be classified as pre-neoplastic or pre-cancerous.
  type: Definition
  has db xref: Journal:_Ward;_J.M._(_2002)_J_Toxicol._Pathol._15;_123-128
    type: DbXref
    has URI: http://purl.org/obo/owl/Journal#Journal__Ward;_J.M._(_2002)_J_Toxicol._Pathol._15;_123-128

focal hyperplasia
type: Class
subclass of: hyperplastic tissue
has OBO namespace: mouse_pathology.ontology
has definition: Localised hyperplastic lesion. Polyclonal lesions are probably benign but clonal lesions may progress to malignancy.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

atypical hyperplasia
type: Class
subclass of: ObsoleteClass
comment: Considered to be too vague to be useful.
has OBO namespace: mouse_pathology.ontology
has definition: Presence of localised areas within for example adenomas showing characteristics of neoplastic (tumor) progression, eg focal carcinoma.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

hyperplastic nodule
type: Class
subclass of: hyperplastic tissue
has OBO namespace: mouse_pathology.ontology
has related synonym: hyperplastic nodules
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Expansion of small hyperplastic lesions to become macroscopically nodules, compressing adjacent cells.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

carcinoma in situ
type: Class
subclass of: ObsoleteClass
comment: Subsumed into MPATH: 132
has OBO namespace: mouse_pathology.ontology
has related synonym: severe intraepithelial neoplasia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Definition
  label: May be used in some systems in preference to its synonyms to indicate lesion specific aprearances. A lesion characterised by changes of the type associated with invasive carcinoma, but physically bounded by the lining epithelium and without local invasion.
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee
has related synonym: severe epithelial dysplasia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

ductal intra-epithelial neoplasia
type: Class
subclass of: glandular tumor
subclass of: potentially cancerous lesions
comment: This term covers the range of DIN (MIN) including severe intra-epithelial neoplasia (IENIII), alternatively termed in situ carcinoma of the mammary ductal epithelium. (M- 8500/2). See Tavassoli FA. (1998) Mod Pathol. 11:140-54. Ductal carcinoma in situ: introduction of the concept of ductal intraepithelial neoplasia for further definition.
has OBO namespace: mouse_pathology.ontology
has definition: Pre-malignant hyperplastic and/or dysplastic change in the mammary gland epithelium with the potential to give rise to malignant tumors.
  type: Definition
  has db xref: PMID:10713680
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_10713680
has related synonym: DIN
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Ductal carcinoma in situ
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: intraductal adenocarcinoma, non-infiltrating
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: mammary intra-epithelial neoplasia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: MIN
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

intestinal intra-epithelial neoplasia
type: Class
subclass of: intra-epithelial neoplasia
has OBO namespace: mouse_pathology.ontology
has definition: Histologically apparent areas of dysplasia that are not grossly visible (smaller than 0.5-1 mm). Lesions may involve single or multiple glands.
  type: Definition
  has db xref: PMID:12612914
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12612914
has related synonym: microadenoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: IIN
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: GIN
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

prostate intra-epithelial neoplasia
type: Class
subclass of: intra-epithelial neoplasia
has OBO namespace: mouse_pathology.ontology
has db xref: URL:_http://emice.nci.nih.gov/emice/mouse_models/organ_models/prostate_models/path_class_mouse
  type: DbXref
  has URI: _http://emice.nci.nih.gov/emice/mouse_models/organ_models/prostate_models/path_class_mouse
has related synonym: PIN
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: See reference for definition.
  type: Definition
  has db xref: ISBN:0-19-512338-7
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0-19-512338-7

stomach, oesophagus and pancreatic intra-epithelial neoplasia
type: Class
subclass of: intra-epithelial neoplasia
has OBO namespace: mouse_pathology.ontology
has definition: stomach, oesophagus and pancreatic intra-epithelial neoplasia
  type: Definition
  has db xref: ISBN:0-19-512338-7
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0-19-512338-7
has related synonym: PANIN
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

demyelination
type: Class
subclass of: intracellular and extracellular depletion
has OBO namespace: mouse_pathology.ontology
has definition: Reduction of myelin content in neuronal sheath.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

adenomatous polyp
type: Class
subclass of: adenoma
subclass of: Restriction
  on property: part of
  some values from: adenomatous polyposis coli
has OBO namespace: mouse_pathology.ontology
has definition: Benign neoplastic growth containing areas of adenomatous structure (progression).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: polypoid adenoma, cellular polyp.
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

polyp
type: Class
subclass of: epithelial hyperplasia
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: A mass of tissue which projects outward or upward from the normal surface level being macroscopically visible as a hemispheroidal, spheroidal, or irregular moundlike structure growing from a relatively broad base or a slender stalk.
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

membraneous glomerulonephritis
type: Class
subclass of: glomerulonephritis
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Glomerulonephritis characterized by diffuse thickening of glomerular capillary basement membranes, due in part to subepithelial deposits of immunoglobulins separated by spikes of basement membrane material,.
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

membraneoproliferative glomerulonephritis
type: Class
subclass of: glomerulonephritis
has OBO namespace: mouse_pathology.ontology
has definition: A chronic glomerulonephritis characterized by mesangial cell proliferation, increased lobular separation of glomeruli, thickening of glomerular capillary walls and increased mesangial matrix,.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

autoimmune glomerulonephritis
type: Class
subclass of: glomerulonephritis
comment: Needs multiple parentage with autoimmune mediated disease
has OBO namespace: mouse_pathology.ontology
has definition: Glomerulonephritis caused by autoimmune attack on the glomerulus.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

glomangioma
type: Class
subclass of: blood vessel tumor
has OBO namespace: mouse_pathology.ontology
has definition: Tumor derived from the capillary glomus with arteriovenous capillary anastomoses. Often characterized by multiple tumors resembling cavernous hemangioma (M-8712/0).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

Non-Lymphoid leukaemias
type: Class
subclass of: Non-Lymphoid neoplasias
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasms of non-lymphoid haematopoietic lineage. Must have at least 20% blast cells to meet this definition.
  type: Definition
  has db xref: PMID:12070033
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070033
has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
  type: DbXref
  has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2

myeloid leukaemia without maturation
type: Class
subclass of: myeloid leukaemia
has OBO namespace: mouse_pathology.ontology
has related synonym: myeloid leukaemia (myeloblastic type)
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: poorly differentiated myeloid leukaemia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Leukaemia in which neoplastic cells are poorly differentiated and not monocytic. At least 90% of the cells have to be blasts.
  type: Definition
  has db xref: PMID:12070033
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070033
has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
  type: DbXref
  has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has related synonym: myeloblastic leukaemia without maturation
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

myeloid leukaemia with maturation
type: Class
subclass of: myeloid leukaemia
has OBO namespace: mouse_pathology.ontology
has related synonym: myeloblastic laeukaemia with maturation
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Leukaemia in which neoplastic cells are moderately differentiated with a neutrophilic but not monocytic component. At least 20% of the cells have to be blasts.
  type: Definition
  has db xref: PMID:12070033
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070033
has related synonym: poorly differentiated myeloid leukaemia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
  type: DbXref
  has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2

nesidioblastosis
type: Class
subclass of: developmental dysplasia
has OBO namespace: mouse_pathology.ontology
has related synonym: diffused or generalised islet cell hyperplasia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: nesidioblastoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: nesidiodysplasia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: focal adenomatosis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: endocrine dysplasia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: multifocal and focal ductulo-insular proliferation (nesidioblastosis)
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: microadenomatosis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: congenital insulinomas
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Beta-cell nesidioblastosis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Abnormal proliferation of beta cells of developing islets often leading to marked diffuse or focal beta-cell hyperplasia. Considered to generate a potentially cancerous lesion.
  type: Definition
  has db xref: PMCID:_1964945
    type: DbXref
    has URI: http://purl.org/obo/owl/PMCID#PMCID__1964945

bridging necrosis
type: Class
subclass of: necrosis
has OBO namespace: mouse_pathology.ontology
has definition: Area of liver necrosis that bridges adjacent portal areas and central veins.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

glycogen depletion
type: Class
subclass of: intracellular and extracellular depletion
has OBO namespace: mouse_pathology.ontology
has definition: Reduction in intracellular glycogen content.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

myeloproliferative disease-like myeloid leukaemia
type: Class
subclass of: myeloid leukaemia
has OBO namespace: mouse_pathology.ontology
has related synonym: myeloid leukaemia, chonic type
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
  type: DbXref
  has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has definition: Leukaemia in which neoplastic cells are well differentiated and in which there are fewer than 20% blasts.
  type: Definition
  has db xref: PMID:12070033
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070033
has related synonym: well differentiated myeloid leukaemia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

myelomonocytic leukaemia
type: Class
subclass of: myeloid leukaemia
has OBO namespace: mouse_pathology.ontology
has related synonym: myeloid leukaemia, myelomonocytic type
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Leukaemia in which neoplastic cells are moderately differentiated with a neutrophilic and a monocytic component. At least 20% of the cells have to be blasts.
  type: Definition
  has db xref: PMID:12070033
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070033
has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
  type: DbXref
  has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2

monocytic leukaemia
type: Class
subclass of: myeloid leukaemia
has OBO namespace: mouse_pathology.ontology
has definition: Leukaemia in which neoplastic cells are poorly or moderately differentiated with a monocytic but no neutrophilic component. At least 20% of the cells must be blasts.
  type: Definition
  has db xref: PMID:12070033
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070033
has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
  type: DbXref
  has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2

biphenotypic leukaemia
type: Class
subclass of: Non-Lymphoid leukaemias
has OBO namespace: mouse_pathology.ontology
has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
  type: DbXref
  has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has definition: A leukaemia with at least 90% blasts and differentiation markers of the myeloid and lymphoid lineage.
  type: Definition
  has db xref: PMID:12070033
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070033

non-lymphoid hematopoietic sarcomas
type: Class
subclass of: hematopoietic/lymphoid malignancies/disorder
subclass of: sarcoma
has OBO namespace: mouse_pathology.ontology
has definition: Solid tumor mass composed of non-lymphoid haematopoietic cells.
  type: Definition
  has db xref: PMID:12070033
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070033
has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
  type: DbXref
  has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2

granulocytic sarcoma
type: Class
subclass of: non-lymphoid hematopoietic sarcomas
has OBO namespace: mouse_pathology.ontology
has definition: Solid tumor mass composed predominantly of granulocytic or relatively undifferentiated non-lymphoid haematopoietic cells.
  type: Definition
  has db xref: PMID:12070033
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070033
has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
  type: DbXref
  has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2

histiocytic sarcoma
type: Class
subclass of: non-lymphoid hematopoietic sarcomas
has OBO namespace: mouse_pathology.ontology
has related synonym: histiocytic lymphoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Kupffer cell sarcoma (sensu liver)
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Solid tumor mass composed predominantly of histiocytic cells (M-9775/3).
  type: Definition
  has db xref: PMID:12070033
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070033
has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
  type: DbXref
  has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has related synonym: reticulum cell sarcoma, type A, reticulosarcoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: malignant lymphoma, histiocytic type
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: reticulum cell sarcoma, type A
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

mast cell sarcoma
type: Class
subclass of: non-lymphoid hematopoietic sarcomas
has OBO namespace: mouse_pathology.ontology
has related synonym: mastocytosis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
  type: DbXref
  has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has related synonym: mast cell tumor
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Solid tumor mass composed of mast cells.
  type: Definition
  has db xref: PMID:12070033
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070033
has related synonym: malignant mastocytoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

myeloid dysplasias
type: Class
subclass of: Non-Lymphoid neoplasias
has OBO namespace: mouse_pathology.ontology
has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
  type: DbXref
  has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has definition: Haematopoietic proliferation with evidence of trilineage dysplasia.
  type: Definition
  has db xref: PMID:12070033
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070033

cytopenia with increased blasts
type: Class
subclass of: myeloid dysplasias
has OBO namespace: mouse_pathology.ontology
has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
  type: DbXref
  has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has definition: Haematopoietic proliferation with evidence of trilineage dysplasia. More than 20% should be blasts.
  type: Definition
  has db xref: PMID:12070033
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070033

hypocalcification
type: Class
subclass of: intracellular and extracellular depletion
has OBO namespace: mouse_pathology.ontology
has definition: Intrinsic abnormally low level of calcification in a tissue cf. MPATH: 48.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

myeloid proliferations (non-reactive)
type: Class
subclass of: Non-Lymphoid neoplasias
has OBO namespace: mouse_pathology.ontology
has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
  type: DbXref
  has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has definition: Non-reactive persistent accumulation of non-lymphoid haematopoietic cells. Genetically determined.
  type: Definition
  has db xref: PMID:12070033
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070033

Myeloproliferation (genetic)
type: Class
subclass of: myeloid proliferations (non-reactive)
has OBO namespace: mouse_pathology.ontology
has definition: Non-reactive persistent accumulation of non-lymphoid haematopoietic cells in the blood which do not infiltrate the spleen and the bone marrow. Genetically determined.
  type: Definition
  has db xref: PMID:12070033
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070033
has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
  type: DbXref
  has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2

myeloproliferative disease
type: Class
subclass of: myeloid proliferations (non-reactive)
has OBO namespace: mouse_pathology.ontology
has definition: Non-reactive persistent accumulation of non-lymphoid haematopoietic cells in the blood which infiltrate the spleen and the bone marrow.
  type: Definition
  has db xref: PMID:12070033
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070033
has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
  type: DbXref
  has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2

Lymphoid neoplasms
type: Class
subclass of: hematopoietic/lymphoid malignancies/disorder
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasms of the B or T cell lineage.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034

B cell neoplasms
type: Class
subclass of: ObsoleteClass
has OBO namespace: mouse_pathology.ontology
has definition: B cell neoplasms
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

Non-Lymphoid neoplasias
type: Class
subclass of: hematopoietic/lymphoid malignancies/disorder
has OBO namespace: mouse_pathology.ontology
has definition: Hematological neoplasias of non-lymphoid origin.
  type: Definition
  has db xref: PMID:12070033
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070033
has db xref: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
  type: DbXref
  has URI: http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2

B-cell neoplasms
type: Class
subclass of: Lymphoid neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasm of the B cell lymphoid lineage.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

precursor B cell neoplasms
type: Class
subclass of: B-cell neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Lymphoma originating from precursor B-cells.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034

precursor B -cell lymphoblastic lymphoma/leukaemia
type: Class
subclass of: precursor B cell neoplasms
has OBO namespace: mouse_pathology.ontology
has related synonym: lymphoblastic leukaemia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: lymphoblastic lymphoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Lymphoma originating in a precursor B-cell.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034

Mature B-cell neoplasms
type: Class
subclass of: B-cell neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Lymphomas originating in peripheral B cells.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034

lipid depletion
type: Class
subclass of: intracellular and extracellular depletion
has OBO namespace: mouse_pathology.ontology
has definition: Reduction in cellular or plasma lipid content.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

small B-cell lymphoma
type: Class
subclass of: Mature B-cell neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Diffuse accumulation of small mature B-cells.
  type: Definition
  has db xref: Book:_Morse;_et_al._(2002)_Blood_100;_246-258
    type: DbXref
    has URI: http://purl.org/obo/owl/Book#Book__Morse;_et_al._(2002)_Blood_100;_246-258
has related synonym: small lymphocytic lymphoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: well differentiated lymphocytic lymphoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

splenic marginal zone lymphoma
type: Class
subclass of: Mature B-cell neoplasms
has OBO namespace: mouse_pathology.ontology
has related synonym: SMZL
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: A lymphoid proliferation of cells of the marginal zone of the white pulp of the spleen.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034

follicular B cell lymphoma
type: Class
subclass of: Mature B-cell neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: A lymphoid proliferation composed of a mixture of centroblasts and centrocytes that may or may not have a nodular(follicular)pattern. The follicular dendritic cell network is not present, unlike in the human. The equivalent typical translocation (Chr. 14:18 )seen in humans has not been reported in the mouse.
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034
has related synonym: centroblastic/centrocytic lymphoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: follicular center cell lymphoma, small cell or mixed
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: follicular lymphoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

Diffuse large B-cell lymphoma
type: Class
subclass of: Mature B-cell neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Diffuse proliferation of large B lymphoid cells.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034
has related synonym: DLBCL
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

diffuse large B-cell lymphoma, centroblastic type
type: Class
subclass of: Diffuse large B-cell lymphoma
has OBO namespace: mouse_pathology.ontology
has definition: Diffuse follicular centre cell lymphoma mainly composed of centroblasts.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034
has related synonym: centroblastic lymphoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

diffuse large B-cell lymphoma, immunoblastic type
type: Class
subclass of: Diffuse large B-cell lymphoma
has OBO namespace: mouse_pathology.ontology
has related synonym: Immunoblastic lymphoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Diffuse large B cell lymphoma with increased number of immunoblasts.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034

diffuse large B-cell lymphoma, histiocyte associated
type: Class
subclass of: Diffuse large B-cell lymphoma
has OBO namespace: mouse_pathology.ontology
has related synonym: DLCL (HS)
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Diffuse large B-cell lymphoma with more than 50% histiocytes.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034

primary mediastinal (thymic) diffuse large B cell lymphoma
type: Class
subclass of: Diffuse large B-cell lymphoma
has OBO namespace: mouse_pathology.ontology
has definition: Primary B-cell lymphoma of the thymus. Reported in C57BL/6 mice infected with replication defective MuLV. Not clear that this is the equivalent of the human disease.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034

classic Burkitt lymphoma
type: Class
subclass of: Mature B-cell neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Highly proliferative B-cell lymphoma characteristically seen in c-Myc transgenic mice, derived from mature B cells.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034

Burkitt-like lymphoma
type: Class
subclass of: Mature B-cell neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Highly proliferative mature B-cell lymphoma, poorly defined.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034

osteopenia
type: Class
subclass of: intracellular and extracellular depletion
has OBO namespace: mouse_pathology.ontology
has definition: Reduced bone mass due to inadequate synthesis of osteoid, resulting in decreased calcification.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

Plasma cell neoplasms
type: Class
subclass of: B-cell neoplasms
has OBO namespace: mouse_pathology.ontology
has db xref: URL:_http://emice.nci.nih.gov/emice/mouse_models/organ_models/hema_models/hema_mouse_class
  type: DbXref
  has URI: _http://emice.nci.nih.gov/emice/mouse_models/organ_models/hema_models/hema_mouse_class
has related synonym: Myeloma ( human )
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Diffuse proliferation of mature plasma cells. Clonal by definition. Includes the equivalent of human myeloma (ICD-O 9732/3).
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034

B-natural killer cell lymphoma
type: Class
subclass of: B-cell neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Unusual lymphoma type described in thymectomised (SL/Kh x AKR/Ms) F1 mice. No equivalent found in human to date. See reference for detailed phenotype.
  type: Definition
  has db xref: Lu;_L-M.;_et_al_(1999)_Jpn_J._Cancer_Res._90:_1218-1223
    type: DbXref
    has URI: http://purl.org/obo/owl/Lu#Lu;_L-M.;_et_al_(1999)_Jpn_J._Cancer_Res._90__1218-1223

plasmacytoma
type: Class
subclass of: Plasma cell neoplasms
comment: Tissue, usually lymph nodes, that contain unusually large numbers of normal appearing plasma cells. While these may be plasmacytomas, additional work is needed to confirm this latter diagnosis.
has OBO namespace: mouse_pathology.ontology
has definition: Diffuse proliferation of mature plasma cells. Clonal by definition.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034
has db xref: URL:_http://emice.nci.nih.gov/emice/mouse_models/organ_models/hema_models/hema_mouse_class
  type: DbXref
  has URI: _http://emice.nci.nih.gov/emice/mouse_models/organ_models/hema_models/hema_mouse_class

extraosseous plasmacytoma
type: Class
subclass of: Plasma cell neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Diffuse proliferation of mature plasma cells. Clonal by definition. Frequently found in IL6 transgenic mice. Characteristically involves spleen and nodes rather than peritoneum.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034

anaplastic plasmacytoma
type: Class
subclass of: Plasma cell neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Diffuse proliferation of immature plasma cells or plasma blasts.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034

T-cell neoplasms
type: Class
subclass of: Lymphoid neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasms derived from cells of the T lymphocyte lineage.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034

precursor T-cell neoplasms
type: Class
subclass of: T-cell neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasms of precursor T cells.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034

precursor T-cell lymphoblastic lymphoma/leukaemia
type: Class
subclass of: precursor T-cell neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Precursor T cell derived neoplasia. Most commonly found in the thymus.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034
has related synonym: thymic lymphoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

mature T-cell neoplasms
type: Class
subclass of: T-cell neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Non-thymic neoplasms of mature T cell origin.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034

small T-cell lymphoma
type: Class
subclass of: mature T-cell neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Accumulation of small mature T cells. No human counterpart known to date.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034

osteoporosis
type: Class
subclass of: intracellular and extracellular depletion
has OBO namespace: mouse_pathology.ontology
has definition: Reduction in the quantity of bone or atrophy of skeletal tissue. More severe than MPATH: 53 with gross changes to bone matrix.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

T cell neoplasms character undetermined
type: Class
subclass of: T-cell neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: T cell neoplasms which cannot currently be classified into known subtypes.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034

T large cell anaplastic lymphoma
type: Class
subclass of: T cell neoplasms character undetermined
has OBO namespace: mouse_pathology.ontology
has definition: Diffuse large pleiomorphic T cell lymphoma. This entity does not correspond to human anaplastic large cell lymphoma.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034

T natural killer cell lymphoma
type: Class
subclass of: T-cell neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Neoplasm of large granular T cells of CD8 phenotype.
  type: Definition
  has db xref: PMID:12070034
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12070034

cholangioma
type: Class
subclass of: hepatic tumor
has OBO namespace: mouse_pathology.ontology
has definition: Benign neoplasm of the biliary duct. Occurs in solid and cystic forms. (M-8160/0).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

hepatocholangiocellular adenoma
type: Class
subclass of: complex tumor
subclass of: adenoma
subclass of: hepatic tumor
has OBO namespace: mouse_pathology.ontology
has definition: Benign tumor of unknown origin showing features of hepatocelluar adenoma and cholangioma.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

hepatocholangiocellular carcinoma
type: Class
subclass of: complex tumor
subclass of: hepatic tumor
subclass of: carcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Malignant tumor of unknown origin showing features of hepatocelluar carcinoma and cholangiocarcinoma. (M-8180/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

blepharitis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology

mucous secretions
type: Class
subclass of: intracellular and extracellular accumulation
comment: Mucus is the clear viscous secretion of the mucous membranes. Consisting of mucin, epithelial cells, leukocytes and various inorganic salts dissolved in water.
has OBO namespace: mouse_pathology.ontology
has definition: Extracellular accumulation of mucous secretions.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

papillary transitional cell carcinoma
type: Class
subclass of: fibroepithelial tumor
subclass of: transitional cell tumor
has OBO namespace: mouse_pathology.ontology
has definition: A generally malignant neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by atypical neoplastic epithelial or urothelial cells cells.
  type: Definition
  has db xref: DbXref
    label: Book:_Kunze;_E._(1994)_Preneoplastic_and_neoplastic_lesions_of_the_Rat_urinary_bladder._In;_Pathology_of_Neoplasia_and_Preneoplasia_in_Rodents._Eds._Bannach;_P.;_and_Goessner;_W.;_Vol_1_p_114._Schattauer;_Stuttgart_New_York
    has URI: http://purl.org/obo/owl/Book#Book__Kunze;_E._(1994)_Preneoplastic_and_neoplastic_lesions_of_the_Rat_urinary_bladder._In;_Pathology_of_Neoplasia_and_Preneoplasia_in_Rodents._Eds._Bannach;_P.;_and_Goess…

carcinoma
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: Any of various types of malignant neoplasm derived from epithelial cells, chiefly glandular (adenocarcinoma) or squamous (squamous cell carcinoma).
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

developmental and structural abnormality
type: Class
subclass of: pathological anatomical entity
has OBO namespace: mouse_pathology.ontology
has definition: Developmental and structural abnormalities occurring during embryonic development or during adult life.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

sarcoma
type: Class
subclass of: ObsoleteClass
has OBO namespace: mouse_pathology.ontology
has definition: A connective tissue neoplasm, usually highly malignant, formed by proliferation of mesodermal cells.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

sarcoma
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: A connective tissue neoplasm, usually highly malignant, formed by proliferation of mesodermal cells.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

Clara cell adenoma
type: Class
subclass of: ObsoleteClass
comment: Merged with MPATH:272 following recommendations of MMHC 2003.
has OBO namespace: mouse_pathology.ontology
has definition: Benign tumor of the Clara cells of the bronchioalveolar epithelium.
  type: Definition
  has db xref: Book:_Hahn;_F.F._and_Boorman;_GA._neoplasia_and_pre-neoplasia_in_the_lung._In_Pathology_of_Neoplasia_and_Preneoplasia_in_Rodents._Vol.2._p_39._(1997)_Schattauer_(_Stuttgart_and_New_York)
    type: DbXref
    has URI: http://purl.org/obo/owl/Book#Book__Hahn;_F.F._and_Boorman;_GA._neoplasia_and_pre-neoplasia_in_the_lung._In_Pathology_of_Neoplasia_and_Preneoplasia_in_Rodents._Vol.2._p_39._(1997)_Schattauer_(_Stuttgar…
has db xref: URL:_http://emice.nci.nih.gov/mouse_models/organ_models/lung_models/murinecancer/tumorclass
  type: DbXref
  has URI: _http://emice.nci.nih.gov/mouse_models/organ_models/lung_models/murinecancer/tumorclass

neuritis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology
has definition: Inflammation of a nerve.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

dystrophy
type: Class
subclass of: process of degenerative change
comment: Most often used for diseases in which a structure does not develop properly (not necessarily in an embryonic context) and undergoes degradation.
has OBO namespace: mouse_pathology.ontology
has definition: Regressive changes which may increase in severity, and which may result from defective nutrition or support of a tissue or organ.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

mineralisation
type: Class
subclass of: intracellular and extracellular accumulation
has OBO namespace: mouse_pathology.ontology
has definition: Deposition of any homogeneous inorganic material.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

potentially cancerous lesions
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: Lesions which in some cases have the potential to become progressively growing malignant tumors.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

aberrant crypt foci
type: Class
subclass of: ObsoleteClass
comment: Use IEN1 MPATH:130 instead. Suppressed as not strictly a histological diagnosis.
has OBO namespace: mouse_pathology.ontology
has related synonym: ACF
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Definition
  label: Sensu gastrointsestinal tract. visible microscopically in whole mount colonic tissue. One or more crypts larger than most, have a thickened layer of epithelial cells that stain more intensely with methylene blue. Some have a slit shaped luminal opening, and increased pericryptal space and are elevated from the focal plane of the microscope. ACF is not a histologic diagnosis.
  has db xref: PMID:12612914
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12612914

adenomyoepithelioma
type: Class
subclass of: complex tumor
has OBO namespace: mouse_pathology.ontology
has definition: Adenocarcinoma type tumor with both glandular and squamous differentiation. (M-8983/0).
  type: Definition
  has db xref: PMID:10713680
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_10713680

Acinar adenocarcinoma
type: Class
subclass of: adenocarcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Tumor composed of small glandular clusters with small lumens.
  type: Definition
  has db xref: PMID:10713680
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_10713680

developmental or adult structural defect
type: Class
subclass of: developmental and structural abnormality
has OBO namespace: mouse_pathology.ontology
has definition: Structural, physical or other general defect of prenatal development of the embryo and the placenta, or such as are acquired in the adult.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

cribriform adenocarcinoma
type: Class
subclass of: adenocarcinoma
has OBO namespace: mouse_pathology.ontology
has definition: Tumor composed of sheets or nests of cells forming lumens with round, punched out spaces.
  type: Definition
  has db xref: PMID:10713680
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_10713680

adenosquamous carcinoma
type: Class
subclass of: adenocarcinoma
subclass of: squamous cell tumor
has OBO namespace: mouse_pathology.ontology
has definition: Mixed adeno- and squamous cell carcinoma. Not yet reported in mice. M-8560/3.
  type: Definition
  has db xref: PMID:12612914
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12612914

torsion
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has definition: The twisting of a bodily organ or part on its own axis.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

mucinous carcinoma
type: Class
subclass of: adenocarcinoma
has OBO namespace: mouse_pathology.ontology
has definition: carcinoma derived from gastrointestinal epithelium with a high mucinous content. (M-8480/3).
  type: Definition
  has db xref: PMID:12612914
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_12612914
has related synonym: mucinous adenocarcinoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

glioblastoma
type: Class
subclass of: glioma
comment: Also see Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Develop primarily through increasing anaplasia of well differentiated gliomas, mainly astrocytomas or oligodendrogliomas. Typically large and contain cells of different sizes with irrregular nuclei and atypical mitotic figures. (M-9440/3).
  has db xref: ISBN-13:9783794515530
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN-13#ISBN-13_9783794515530
has related synonym: monstrocytoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: glioblastoma multiforme
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

tumors of neurepithelial tissue
type: Class
subclass of: central nervous system tumor
has OBO namespace: mouse_pathology.ontology
has definition: Tumors of neuronal and non-neuronal cells derived from embryonic neurepithelium.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

tumors of the meninges
type: Class
subclass of: central nervous system tumor
has OBO namespace: mouse_pathology.ontology
has definition: tumors of the meninges
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

pilocytic astrocytoma
type: Class
subclass of: astrocytoma
comment: Often cystic in children and generally considered benign.
has OBO namespace: mouse_pathology.ontology
has related synonym: cystic cerebellar astrocytoma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Glial cell derived tumor composed of bipolar cells with long `hairlike` GFAP-positive processes. (M9421/1).
  type: Definition
  has db xref: Nervous_System._Radovsky_A_and_Mahler;_J.S._In:_Maronpot;_R._Pathology_of_the_Mouse._(1999)_Cache_River_Press._Vienna_IL
    type: DbXref
    has URI: http://purl.org/obo/owl/Nervous_System._Radovsky_A_and_Mahler#Nervous_System._Radovsky_A_and_Mahler;_J.S._In__Maronpot;_R._Pathology_of_the_Mouse._(1999)_Cache_River_Press._Vienna_IL

mixed glioma
type: Class
subclass of: glioma
subclass of: complex tumor
comment: Also see Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.
has OBO namespace: mouse_pathology.ontology
has definition: Mixed tumor containing astrocytes within an oligodendroglioma or vice versa. In some cases both components may be neoplastic. (M-9382/3).
  type: Definition
  has db xref: ISBN-13:9783794515530
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN-13#ISBN-13_9783794515530

granular cell tumor
type: Class
subclass of: ObsoleteClass
comment: Subsumed into MP:413 as incidence in meninges, whilst a characteristic lesion, is the same type of tumor as that originally classified under myomatous tumors. Describe meningeal granular cell tumor using MP:413 and the anatomical descriptor.
has OBO namespace: mouse_pathology.ontology
has definition: granular cell tumor
  type: Definition
  has db xref: ISBN-13:9783794515530
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN-13#ISBN-13_9783794515530

agenesis
type: Class
subclass of: developmental process abnormalities
has OBO namespace: mouse_pathology.ontology
has definition: Failure of a tissue or organ to develop.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee
has related synonym: Agenesia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

peripheral nervous system tumors
type: Class
subclass of: neoplasm
has OBO namespace: mouse_pathology.ontology
has definition: Tumors of the peripheral nervous system.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

pilomatricoma
type: Class
subclass of: basaloid follicular neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Tumor composed of the epithelial components of the most proximal (trichogenic) portion of the hair follicle associated with an aberrent hair cortex type of cornification (ghost cells or shadow cells). The most primitive cellular component consists of basophilic cells having scanty cytoplasm and nuclei that occasionally overlap to some extent. In humans mineralisation is common.
  has db xref: See:_Gat;_U.;_DasGupta;_R.;_Degenstein;_L._and_Fuchs;_E._(1998)_De_Novo_hair_follicle_morphogenesis_and_hair_tumors_in_mice_expressing_a_truncated_beta-catenin_in_skin_Cell;_95;_605-614.
    type: DbXref
    has URI: http://purl.org/obo/owl/See#See__Gat;_U.;_DasGupta;_R.;_Degenstein;_L._and_Fuchs;_E._(1998)_De_Novo_hair_follicle_morphogenesis_and_hair_tumors_in_mice_expressing_a_truncated_beta-catenin_in_skin_Cell…

ossifying fibroma
type: Class
subclass of: osseous and chondromatous tumor
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Ossifying fibromas are benign tumors derived from pluripotential mesenchymal stem cells or osteoblasts. Occur spontaneously or in response to radiation. Preferentially located in mandible, maxilla and caudal spine. Composed of a characteristically regular trabecular bone pattern embedded in a fibrous stroma. Proliferating component consists of spindle cells which give rise to cuboidal osteoblasts to form rounded bodies or trabeculae. Bone trabeculae resemble the alphabet soup shapes characteristic of fibrous dysplasia in humans. In contrast to fibrous dysplasia the bone trabeculae of ossifying fibroma are mostly lamellar and ringed by active osteoblasts.
  has db xref: DbXref
    label: Book:_Luz_A;_Goessner;_W.;and_Murray_AB.(1991)_Ossifying_fibroma;_mouse._In;_Jones_TC;_Mohr_U;_Hunt_RD_(eds)_Monographs_on_pathology_of_laboratory_animals._Cardiovascular_and_musculoskeletal_systems._Springer;_Berlin_Heidelberg_New_York_Tokyo;_pp_228-232
    has URI: http://purl.org/obo/owl/Book#Book__Luz_A;_Goessner;_W.;and_Murray_AB.(1991)_Ossifying_fibroma;_mouse._In;_Jones_TC;_Mohr_U;_Hunt_RD_(eds)_Monographs_on_pathology_of_laboratory_animals._Cardiovascular_…

inverted transitional cell papilloma
type: Class
subclass of: transitional cell papilloma
has OBO namespace: mouse_pathology.ontology
has definition: Pre-malignant lesion of transitional cells, papillomatous form, in which proliferating epithelium is invaginated beneath the surface.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

nephroblastomatosis
type: Class
subclass of: developmental dysplasia
has OBO namespace: mouse_pathology.ontology
has definition: Persistence of metanephrogenic blastema or its presence in the wrong place or at the wrong time. Associated with hyperplastic nephrogenic rests.
  type: Definition
  has db xref: PMID:8383276
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_8383276

basaloid follicular neoplasms
type: Class
subclass of: adnexal and skin appendage tumor
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: This is a new diagnostic term that the MMHC pathology panel felt best described a diagnostically challenging set of tumors that share the feature of being compose of basaloid cells showing follicular differentiation to some extent. These tumors are common in GEM involving the hedgehog signaling pathway and frequently have more than one of the histologic patterns listed below. The designation of benign and malignant has been excluded from the primary diagnosis purposely, as this is frequently difficult to determine in these characteristically well circumscribed tumors. The presence of a disorganized (non-palisaded) sheet-like growth pattern, tumor necrosis, or numerous mitoses are felt to represent malignant transformation.
  has db xref: URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models
    type: DbXref
    has URI: http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models

trichofolliculoma
type: Class
subclass of: Restriction
  on property: part of
  some values from: basaloid follicular neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Basaloid neoplasm with numerous mature hair follicles and hair formation.
  type: Definition
  has db xref: URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models
    type: DbXref
    has URI: http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models

spiradenoma
type: Class
subclass of: basaloid follicular neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Cellular neoplasm with well formed palisades of basaloid cells adjacent to less basophilic smaller cells with occasional central deposition of amorphous eosinophilic material. These tumors share some features with cylindroma type tumors but have a less well developed jigsaw puzzle-like architecture and tend to be more cellular.
  has db xref: URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models/hierarchical_classification
    type: DbXref
    has URI: http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models/hierarchical_classification

trichoblastoma
type: Class
subclass of: basaloid follicular neoplasms
has OBO namespace: mouse_pathology.ontology
has definition: Basaloid neoplasm with frequent primitive hair follicles.
  type: Definition
  has db xref: URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models/hierarchical_classification
    type: DbXref
    has URI: http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models/hierarchical_classification

ulcer
type: Class
subclass of: cell and tissue damage
has OBO namespace: mouse_pathology.ontology
has definition: Loss of epithelium and the basement membrane (full thickness). Cf Erosion.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

aplasia
type: Class
subclass of: developmental process abnormalities
has OBO namespace: mouse_pathology.ontology
has definition: Absence of an organ or tissue coupled with persistence of the organ/tissue primordium, which fails to develop completely.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

erosion
type: Class
subclass of: general degenerative process
has OBO namespace: mouse_pathology.ontology
has definition: Partial epithelial denudation not penetrating to the basement membrane.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

desmoplasia
type: Class
subclass of: defective growth and differentiation process
has OBO namespace: mouse_pathology.ontology
has related synonym: scirrhous
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: sclerosis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Connective tissue proliferative reaction induced by a neoplastic process.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

Cicatricial alopecia
type: Class
subclass of: alopecia
has OBO namespace: mouse_pathology.ontology
has definition: Scarring of the hair follicle without affecting the adjacent dermis. Pigment may be associated with fibrous tract in pigmented individuals.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

scarring alopecia
type: Class
subclass of: alopecia
has OBO namespace: mouse_pathology.ontology
has definition: Loss of hair follicles in a diffuse dermal scar.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

myelofibrosis
type: Class
subclass of: tissue specific degenerative process
has OBO namespace: mouse_pathology.ontology
has definition: In mice the term refers to accumulation of fibrous connective tissue in the medullary cavity of bones; usually in old mice. In humans the term is synonymous with myeloid metaplasia.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

acidophilic macrophage pneumonia
type: Class
subclass of: intracellular and extracellular accumulation
comment: Crystals and acidophilic material have been reported as various materials including Ym1 and Ym2 proteins and blood pigment derivatives and Eotaxin.
has OBO namespace: mouse_pathology.ontology
has definition: A mixed inflammatory infiltrate in the pulmonary airways with predominant intra-alveolar macrophage component with intra- and extracellular, elongated, bright eosinophilic/acidophilic crystals.
  type: Definition
  has db xref: NULL:Murray_AB;_Luz_A_(_1990_)_Acidophilic_macrophage_pneumonia_in_laboratory_mice._Vet_Pathol._27;_274-81
    type: DbXref
    has URI: http://purl.org/obo/owl/NULL#NULL_Murray_AB;_Luz_A_(_1990_)_Acidophilic_macrophage_pneumonia_in_laboratory_mice._Vet_Pathol._27;_274-81

polycystic disease
type: Class
subclass of: tissue specific degenerative process
has OBO namespace: mouse_pathology.ontology
has related synonym: polycystic liver disease
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: polycystic kidney disease
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: polycystic ovary
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: A group of degenerative disorders resulting in multiple cysts in tissues.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

Cribriform epididymal hyperplasia
type: Class
subclass of: hyperplastic tissue
comment: Cribriform epididymal hyperplasia was initially described as an incidental finding in human orchidectomy specimens. Recently, this condition was also described in mice, homozygous for a targeted mutation in p53.
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: The lesion is characterized microscopically by epithelial cells with atypical hyperchromatic nuclei, vacuolization, intratubular lumina formation, infrequent apoptosis, and rare mitotic figures. In contrast to germ cells, the cells of CEH do not express alpha-fetoprotein, carcinoembryonic antigen, or S-100. Ultrastructurally, the cells are pleomorphic with stereocilia at their apical borders and within intratubular lumina, and are supported by a basement membrane. CEH does not appear to be a preneoplastic change.
  has db xref: Journal:_La_Perle_KM;_Blomme_EA;_Sagartz_JE;_Capen_CC_(2002)_Epididymal_cribriform_hyperplasia_with_nuclear_atypia_in_p53_homozygous_knockout._Comp_Med._2002_52:568-71.
    type: DbXref
    has URI: http://purl.org/obo/owl/Journal#Journal__La_Perle_KM;_Blomme_EA;_Sagartz_JE;_Capen_CC_(2002)_Epididymal_cribriform_hyperplasia_with_nuclear_atypia_in_p53_homozygous_knockout._Comp_Med._2002_52:568-71.

Dysplasia
type: Class
subclass of: ObsoleteClass
has OBO namespace: mouse_pathology.ontology
has definition: Dysplasia
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

dysplasia
type: Class
subclass of: defective growth and differentiation process
comment: Note that with respect to developmental processes the term dysplasia is often used with greater specificity to describe aberrant developmental processes of proliferation and differentation, in which case MPATH: 64 Developmental dysplasia should be used.
has OBO namespace: mouse_pathology.ontology
has definition: Distortion or deficiency of the tissue or cellular architecture.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

defective branching morphogenesis
type: Class
subclass of: developmental process abnormalities
has OBO namespace: mouse_pathology.ontology
has definition: Defect in the process determining number, angle, pattern or rate of branching of tubular branched structures eg. Glandular ducts.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

fibro-osseous lesion
type: Class
subclass of: dysplasia
comment: The benign fibro-osseous lesions (BFOL) represent a clinically diverse group of disorders of bone that share similar histopathologic features. As a group, they are relatively common in the craniofacial complex, especially the jaws. Common in some inbred strains notably B6C3F1 females. Note that many of the synonyms have been used historically and may not be accurate. See: Albassam MA, Courtney CL (1996) Nonneoplastic and neoplastic lesions of the bone. In: Mohr U, Dungworth DL, Capen CC, Carlton WW, Sundberg JP, Ward JM (eds) Pathobiology of the aging mouse. Vol 2. Musculoskeletal system. ILSI Press, Washington D.C., pp 425-437. AND Albassam MA, Wojcinski ZW, Barsoum NJ, Smith, GS (1991) Spontaneous fibro-osseous proliferative lesions in the sternums and femurs of B6C3F1 mice. Vet Path 28: 381-388.
has OBO namespace: mouse_pathology.ontology
has related synonym: osteofibrosis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: fibrous dysplasia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: osteodystrophy
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: osteodysplasia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Lesion of bone showing accelerated osteoclastic bone resorption coupled with fibroplasia. Later stages show proliferation of osteoblasts.
  type: Definition
  has db xref: DbXref
    label: Book:_Albassam_MA;_Courtney_CL_(1996)_Nonneoplastic_and_neoplastic_lesions_of_the_bone._In;_Mohr_U;_Dungworth_DL;_Capen_CC;_Carlton_WW;_Sundberg_JP;_Ward_JM_(eds)_Pathobiology_of_the_aging_mouse._Vol_2._Musculoskeletal_system._ILSI_Press;_Washington_D.C.;_pp_425-437
    has URI: http://purl.org/obo/owl/Book#Book__Albassam_MA;_Courtney_CL_(1996)_Nonneoplastic_and_neoplastic_lesions_of_the_bone._In;_Mohr_U;_Dungworth_DL;_Capen_CC;_Carlton_WW;_Sundberg_JP;_Ward_JM_(eds)_Pathobio…
has related synonym: fibrous osteodystrophy
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

fatty infiltration
type: Class
subclass of: healing and repair structure
has OBO namespace: mouse_pathology.ontology
has definition: Accumulation of mature adipose tissue in a healing wound site or otherwise in response to tissue damage.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

osteopetrosis
type: Class
subclass of: dysplasia
has OBO namespace: mouse_pathology.ontology
has related synonym: marble bones
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Albers-Schoenberg disease
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: marble bone disease
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Definition
  label: Excessive formation of dense trabecular bone and mineralized cartilage, especially in long bones, leading to obliteration of marrow spaces and to anemia with myeloid metaplasia and hepatosplenomegaly beginning in infancy, to bone fragility, and to progressive deafness and blindness.
  has db xref: PMID:15625335
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_15625335

Myeloma
type: Class
subclass of: ObsoleteClass
has OBO namespace: mouse_pathology.ontology
has definition: Plasma cell myeloma - (ICD-O 9732/3).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

cystic hyperplasia
type: Class
subclass of: epithelial and stromal hyperplasia
has OBO namespace: mouse_pathology.ontology
has definition: Formation of multiple retention cysts from obstruction of ducts or glands by hyperplasia of the lining epithelium.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

extramedullary hemopoiesis
type: Class
subclass of: Non-Lymphoid neoplasias
comment: Production of blood cells in tissues other than the bone marrow. In the mouse, this is usually the liver.
has OBO namespace: mouse_pathology.ontology
has definition: The formation of and development of blood cells outside the red pulp of the spleen. Composed of varying numbers of megakaryocytes as well as myeloid and erythroid precursors.
  type: Definition
  has db xref: NULL:Ward;_J.M.;_Mann;_P.C.;_Mrishima;_H.;_and_Frith;_C.H._Thymus;_Spleen_and_Lymph_nodes._Ch_13._p342._In_Maronpot;_R._Pathology_of_the_Mouse._(1999)_Cache_River_Press._Vienna_IL
    type: DbXref
    has URI: http://purl.org/obo/owl/NULL#NULL_Ward;_J.M.;_Mann;_P.C.;_Mrishima;_H.;_and_Frith;_C.H._Thymus;_Spleen_and_Lymph_nodes._Ch_13._p342._In_Maronpot;_R._Pathology_of_the_Mouse._(1999)_Cache_River_Press._V…

pathological process
type: Class
subclass of: pathology_ontology
has OBO namespace: mouse_pathology.ontology
has definition: The organic response of tissues to external insult, injury or underlying genetic or epigenetic lesion.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

cell and tissue damage process
type: Class
subclass of: pathological process
has OBO namespace: mouse_pathology.ontology
has definition: Processes occurring during cell and tissue damage of either intrinsic or extrinsic etiology.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

degenerative entity
type: Class
subclass of: ObsoleteClass
has OBO namespace: mouse_pathology.ontology
has definition: degenerative entity
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

developmental process abnormalities
type: Class
subclass of: pathological process
has OBO namespace: mouse_pathology.ontology
has definition: developmental process abnormalities
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

caseous necrosis
type: Class
subclass of: necrosis
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Necrosis characteristic of some inflammatory conditions which represents necrosis with loss of structure of the various cellular and tissue elements; affected tissue manifests a friable, crumbly consistency.
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

communication defect
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has definition: Failure of two cavities, voids or lumens to connect.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

branching defect
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has definition: Aberrant branch or branching pattern of a branched structure such as the bronchus.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

developmental hypertrophy
type: Class
subclass of: developmental process abnormalities
has OBO namespace: mouse_pathology.ontology
has definition: Increase of the size or cellularity of an organ or tissue as a consequence of loss of normal regulation of cell proliferation.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

hyperplastic tissue
type: Class
subclass of: growth and differentiation defect
has OBO namespace: mouse_pathology.ontology
has definition: An organ or a tissue with an abnormal increase in the number of cells as a consequence of cell proliferation.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

pathological anatomical entity
type: Class
subclass of: pathology_ontology
has OBO namespace: mouse_pathology.ontology
has definition: Anatomically located instance of pathological response or entity.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

defective growth and differentiation process
type: Class
subclass of: pathological process
comment: Excludes abnormalities of developmental proliferation and differentiation.
has OBO namespace: mouse_pathology.ontology
has definition: Abnormal increase or decrease in the rate of cell growth or cell division including associated changes in the differentiation state of adult cells.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

metaplastic tissue
type: Class
subclass of: growth and differentiation defect
comment: Nearly exclusively used in an adult context.
has OBO namespace: mouse_pathology.ontology
has definition: A tissue or group of cells in which there has been abnormal transformation of an fully differentiated adult cell or tissue of one kind into a differentiated tissue of another kind.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

neoplasia
type: Class
subclass of: pathological process
comment: Literally: new growth of cells. Neoplasia refers to the unscheduled or abnormal growth of cells, potentially resulting in a benign or malignant tumour. Neoplasms include potentially cancerous lesions as well as full malignancies but not all neoplasms are potentially cancerous.
has OBO namespace: mouse_pathology.ontology
has related synonym: neoplastic process
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: The pathological process that results in the formation and growth of a neoplasm.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

healing and repair structure
type: Class
subclass of: pathological anatomical entity
has OBO namespace: mouse_pathology.ontology
has definition: Physical entity or structure associated with normal or abnormal tissue healing or repair following extrinsic or intrinsic damage.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

abscess
type: Class
subclass of: healing and repair structure
comment: Generally occur following damage or infection with subsequent inflammatory response. Result of the body`s defensive reaction to foreign material.
has OBO namespace: mouse_pathology.ontology
has definition: A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

empyema
type: Class
subclass of: healing and repair structure
has OBO namespace: mouse_pathology.ontology
has definition: Pus in a body cavity; when used without qualification, refers specifically to pyothorax.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

curvature defect
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has definition: Inappropriate curvature of a structure.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

angiectasia
type: Class
subclass of: ectasia
has OBO namespace: mouse_pathology.ontology
has definition: Dilatation of a blood vessel or valve.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

glossitis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology
has definition: Acute or chronic inflammation of the tongue.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

Abscess
type: Class
subclass of: ObsoleteClass
comment: Alternately a cavity formed by liquefactive necrosis within solid tissue. Obsoleted by MPATH 608
has OBO namespace: mouse_pathology.ontology
has definition: A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

pigmentation
type: Class
subclass of: intracellular and extracellular accumulation
has OBO namespace: mouse_pathology.ontology
has definition: Coloration, either normal or pathologic, of the skin or tissues resulting from a deposit of pigment.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

concretion
type: Class
subclass of: intracellular and extracellular accumulation
has OBO namespace: mouse_pathology.ontology
has definition: Solid material formed by aggregation of discrete units or particles.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

cardiomyopathy
type: Class
subclass of: tissue specific degenerative process
comment: Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive.
has OBO namespace: mouse_pathology.ontology
has definition: A disease of the heart muscle or myocardium proper.
  type: Definition
  has db xref: NULL:NCI_Thesaurus_/_A7567983
    type: DbXref
    has URI: http://purl.org/obo/owl/NULL#NULL_NCI_Thesaurus_/_A7567983

hyperostosis
type: Class
subclass of: hypertrophy
has OBO namespace: mouse_pathology.ontology
has related synonym: osteosclerosis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Hypertrophy of bone characterised by an abnormal increase in non-neoplastic skeletal bone mass. These may be proliferative or non-proliferative lesions.
  type: Definition
  has db xref: Long;_P.H.;_and_Leininger;_J.R_(_1999)_Bones_Joints_and_synovia;_p663._in:_Pathology_of_the_Mouse._Ed_Maronpot;_R._Cache_River_Press
    type: DbXref
    has URI: http://purl.org/obo/owl/Long#Long;_P.H.;_and_Leininger;_J.R_(_1999)_Bones_Joints_and_synovia;_p663._in__Pathology_of_the_Mouse._Ed_Maronpot;_R._Cache_River_Press

focus of cellular alteration
type: Class
subclass of: potentially cancerous lesions
comment: More recently amphophilic cell foci, diffusely basophilic cell foci and vacuolated cell foci have been described.
has OBO namespace: mouse_pathology.ontology
has related synonym: Enzyme altered focus
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Areas of cellular alteration
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Preneoplastic focus
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Hyperplastic focus
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Phenotypically altered focus
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Focus of altered hepatocytes (fah)
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Focal lesions of hepatocytes characterised primarily by altered cytoplasmic tinctorial properties. Classified as basophilic, eosinophilic, clear cell or mixed type.
  type: Definition
  has db xref: Pathbase:_Mohr
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Mohr

myeloid hyperplasia
type: Class
subclass of: Non-Lymphoid neoplasias
comment: Myeloid hyperplasia ia a common diagnosis in mouse spleen. In the normal mouse spleen, a low degree of production of myeloid cells occurs (neutrophils, erythroid cells and megakaryocytes). Commonly in aging mice, due to tumors and inflammatory lesions, the mouse myeloid system in bone marrow and spleen react and become hyperplastic. In the spleen it is diagnosed as "myeloid hyperplasia" (MH), in the past it was often extramedullary hematopoiesis, which is still used by some but it is normal to a low degree in normal mouse spleen.
has OBO namespace: mouse_pathology.ontology
has definition: Hyperplasia of myeloid lineage, usually in the spleen.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

truncoconal septal defect
type: Class
subclass of: cardiac septation defect
has OBO namespace: mouse_pathology.ontology
has definition: Septal defect lying between the aorta and pulmonary trunks caused by failure of the spiral septum to separate the truncus arteriosus.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

cyst
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has definition: Formation of an epithelium bounded cavity not associated with neoplasia.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

inter-atrial septal defect
type: Class
subclass of: cardiac septation defect
has OBO namespace: mouse_pathology.ontology
has definition: Incomplete closure of the inter-atrial septum due to failure of the primary or secondary septum.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

inter-ventricular septal defect
type: Class
subclass of: cardiac septation defect
has OBO namespace: mouse_pathology.ontology
has definition: Failure of the inter-ventricular septum to completely close between the left and right ventricles.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

steatosis
type: Class
subclass of: intracellular and extracellular accumulation
comment: Most commonly associated with degenerative change in the liver.
has OBO namespace: mouse_pathology.ontology
has related synonym: adipose degeneration
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: fatty change
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Abnormal retention of lipids within a cell. Physically apparent as lipid within liposomes of parenchymal cells.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: fatty degeneration
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

synechia
type: Class
subclass of: developmental or adult structural defect
comment: May also be seen in the uterus ( in humans Asherman`s syndrome).
has OBO namespace: mouse_pathology.ontology
has definition: An adhesion, usually between the iris and the cornea or the lens capsule.
  type: Definition
  has db xref: Millodot;_Michel_and_Daniel_Laby._Dictionary_of_Ophthalmology._London:_Butterworth_Heinemann;_2002
    type: DbXref
    has URI: http://purl.org/obo/owl/Millodot#Millodot;_Michel_and_Daniel_Laby._Dictionary_of_Ophthalmology._London__Butterworth_Heinemann;_2002

involution
type: Class
subclass of: developmental or adult structural defect
comment: Not return of an enlarged organ to its normal size.
has OBO namespace: mouse_pathology.ontology
has definition: Turning in of the edges of a structure.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

avulsion
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has definition: Tearing away or separation of two structures or parts.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

prolapse
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has definition: To sink down, said of an organ or other part. A sinking of an organ or other part, especially its appearance at a natural or artificial orifice.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

pyogranulomatous inflammation
type: Class
subclass of: granulomatous inflammation
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: An inflammatory process in which there is infiltration of polymorphonuclear cells into a more chronic area of inflammation characterized by mononuclear cells, macrophages, lymphocytes and possibly plasma cells.
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

pyogenic granuloma
type: Class
subclass of: hemangioma
has OBO namespace: mouse_pathology.ontology
has definition: A small rounded mass of inflamed, highly vascular granulation tissue on the skin, frequently having an ulcerated surface. More likely a true neoplasm rather than a reactive lesion.
  type: Definition
  has db xref: DbXref
    label: Mills;_S.E.;_Cooper;_P.H._&_Fechner;_R.E._(1980)._Lobular_capillary_hemangioma:_the_underlying_lesion_of_pyogenic_granuloma._A_study_of_73_cases_from_the_oral_and_nasal_mucous_membranes._Am_J_Surg_Pathol;_4;_470-9.
    has URI: http://purl.org/obo/owl/Mills#Mills;_S.E.;_Cooper;_P.H._&_Fechner;_R.E._(1980)._Lobular_capillary_hemangioma__the_underlying_lesion_of_pyogenic_granuloma._A_study_of_73_cases_from_the_oral_and_nasal_m…
has related synonym: lobular capillary hemangioma
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

cavernous hemangioma
type: Class
subclass of: hemangioma
has OBO namespace: mouse_pathology.ontology
has definition: Deep cutaneous hemangioma with large dilated vascular spaces that manifests spontaneous involution.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

depletion
type: Class
subclass of: developmental process abnormalities
has OBO namespace: mouse_pathology.ontology
has definition: The removal of accumulated fluids or solids.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

karyomegaly
type: Class
subclass of: nuclear defect
has OBO namespace: mouse_pathology.ontology
has definition: Abnormally increased nuclear size.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

hypertrophic tissue
type: Class
subclass of: growth and differentiation defect
has OBO namespace: mouse_pathology.ontology
has definition: Tissue or cells undergoing hypertrophy, MPATH: 159.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

Hepatocytomegaly
type: Class
subclass of: hypertrophic tissue
comment: Hepatocytomegaly is an enlargement of the hepatocytes and is generally classified into three types: hepatocellular hypertrophy, megalocytosis, and hepatocellular vacuolation. Hepatocellular hypertrophy is an enlargement of cellular diameter without accompanying nuclear changes, leading to a net gain in the dry mass of the liver. Megalocytosis is characterized by enlargement of both the cell and the nucleus, and hepatocellular vacuolation is characterized by vacuolation, or formation of pockets of fluid within the hepatocytes.
has OBO namespace: mouse_pathology.ontology
has definition: Increase in size of hepatocytes characterised by organelle hyperplasia and enlarged cellular volume.
  type: Definition
  has db xref: Journal:_Ward;_J.M.;_Anver;_M.R.;_Haines;_D.C._&_Benveniste;_R.E._(1994)._Chronic_active_hepatitis_in_mice_caused_by_Helicobacter_hepaticus._Am_J_Pathol;_145;_959-68.
    type: DbXref
    has URI: http://purl.org/obo/owl/Journal#Journal__Ward;_J.M.;_Anver;_M.R.;_Haines;_D.C._&_Benveniste;_R.E._(1994)._Chronic_active_hepatitis_in_mice_caused_by_Helicobacter_hepaticus._Am_J_Pathol;_145;_959-68.
has db xref: PMID:7943185
  type: DbXref
  has URI: http://purl.org/obo/owl/PMID#PMID_7943185

cholelithiasis
type: Class
subclass of: concretion
has OBO namespace: mouse_pathology.ontology
has definition: Presence of concretions in the gallbladder or bile ducts.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

furunculosis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology
has definition: Focal suppurative inflammation of the skin and subcutaneous tissues, enclosing a central slough or `core`.
  type: Definition
  has db xref: ISBN:9780702027888
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_9780702027888
has related synonym: Boil
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

hydronephrosis
type: Class
subclass of: pyelectasia
has OBO namespace: mouse_pathology.ontology
has definition: Swelling of the kidneys when urine flow is obstructed in any of part of the urinary tract. Severe form of pyelectasia.
  type: Definition
  has db xref: ISBN:9780702027888
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_9780702027888

steatitis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology
has definition: Inflammation of fatty tissue.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

bursal cyst
type: Class
subclass of: cyst
has OBO namespace: mouse_pathology.ontology
has definition: A retention cyst, resulting from an obstruction to the duct of a gland, within a bursa.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

cellulitis
type: Class
subclass of: inflammation
comment: It is usually caused by infection of an operative or traumatic wound, burn or other cutaneous lesion by various bacteria, but group A streptococci and Staphylococcus aureus are the most common aetiological agents.
has OBO namespace: mouse_pathology.ontology
has definition: An acute, diffuse, spreading, edematous, suppurative inflammation of the deep subcutaneous tissues and sometimes muscle, which may be associated with abscess formation.
  type: Definition
  has db xref: URL:http://cancerweb.ncl.ac.uk/cgi-bin/omd?action=Search+OMD&query=cellulitis
    type: DbXref
    has URI: http://cancerweb.ncl.ac.uk/cgi-bin/omd

hydrocephalus
type: Class
subclass of: intracellular and extracellular accumulation
has OBO namespace: mouse_pathology.ontology
has definition: Accumulation of water in the ventricles of the brain.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

developmental dysplasia
type: Class
subclass of: developmental process abnormalities
comment: The word dysplasia as commonly used refers to a precursor state to neoplasia. This is not the context used for this MPATH term.
has OBO namespace: mouse_pathology.ontology
has definition: Abnormal development (of organs or tissues) or an abnormal structure resulting from such growth.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

osteoid deposition
type: Class
subclass of: extracellular matrix deposition
has OBO namespace: mouse_pathology.ontology
has definition: Deposition of organic bone matrix.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

epidermal inclusion cyst
type: Class
subclass of: cyst
has OBO namespace: mouse_pathology.ontology
has definition: Intradermal or subcutaneous cyst, the wall of which is stratified epithelium containing keratohyalin granules, surrounding a core of debris.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

cholesterol deposition
type: Class
subclass of: intracellular and extracellular accumulation
comment: Often diagnosed morphologically by the presence of cholesterol clefts - bare regions of a section where accumulated cholesterol has been removed by histological processing.
has OBO namespace: mouse_pathology.ontology
has definition: Intra or extracellular deposition of cholesterol.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

serous exudate
type: Class
subclass of: fluid accumulation
has OBO namespace: mouse_pathology.ontology
has definition: Non-cellular fluid that filters from the circulatory system and accumulates in lesions or areas of inflammation.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

crystalloid formation
type: Class
subclass of: intracellular and extracellular accumulation
has OBO namespace: mouse_pathology.ontology
has definition: Accumulation of chitinase-like protein.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

epicarditis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology

chondroarthritis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology

interstitial nephritis
type: Class
subclass of: inflammation
subclass of: nephritis
has OBO namespace: mouse_pathology.ontology

interstitial pancreatitis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology

otitis media
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology

developmental hypoplasia
type: Class
subclass of: ObsoleteClass
has OBO namespace: mouse_pathology.ontology
has definition: Underdevelopment of an organ due to a decrease in the number of cells through failure to proliferate leading to lack of development.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

proliferative dermatitis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology

ventral glossitis
type: Class
subclass of: glossitis
has OBO namespace: mouse_pathology.ontology

histiocytosis
type: Class
subclass of: immune mediated disease
has OBO namespace: mouse_pathology.ontology

langerhans cell histiocytosis
type: Class
subclass of: histiocytosis
has OBO namespace: mouse_pathology.ontology
has exact synonym: histiocytosis X

non-Langerhans cell histiocytosis
type: Class
subclass of: histiocytosis
has OBO namespace: mouse_pathology.ontology
has exact synonym: hemophagocytic syndrome

lingual adenitis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology

hemolysis
type: Class
subclass of: tissue specific degenerative process
comment: May be immune-mediated, induced by infectious organisms, or intrinsic disturbance of cell physiology or membrane/cytoskeletal integrity.
has OBO namespace: mouse_pathology.ontology
has definition: Rupture or disruption of erythrocytes with release of contents.
  type: Definition
  has db xref: MPATH:Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/MPATH#MPATH_Curation

rhinitis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology

foreign body rhinitis
type: Class
subclass of: rhinitis
has OBO namespace: mouse_pathology.ontology

foreign body dermatitis
type: Class
subclass of: dermatitis
has OBO namespace: mouse_pathology.ontology

dilatation
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has definition: Increase in the diameter of an orifice or tubular structure beyond its normal dimensions.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

gastritis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology

foreign body gastritis
type: Class
subclass of: gastritis
has OBO namespace: mouse_pathology.ontology

foreign body glossitis
type: Class
subclass of: glossitis
has OBO namespace: mouse_pathology.ontology

peritonitis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology

granulomatous peritonitis
type: Class
subclass of: granulomatous inflammation
subclass of: peritonitis
has OBO namespace: mouse_pathology.ontology

foreign body granulomatous peritonitis
type: Class
subclass of: granulomatous inflammation
subclass of: peritonitis
has OBO namespace: mouse_pathology.ontology

periodontitis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology

foreign body periodontitis
type: Class
subclass of: periodontitis
has OBO namespace: mouse_pathology.ontology

tracheitis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology

foreign body tracheitis
type: Class
subclass of: tracheitis
has OBO namespace: mouse_pathology.ontology

displacement and deformity
type: Class
subclass of: developmental process abnormalities
has OBO namespace: mouse_pathology.ontology
has definition: Abnormal location, orientation, number, loss or non-specified deformity of a structure or tissue.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

granulomatous epicarditis
type: Class
subclass of: granulomatous inflammation
subclass of: epicarditis
has OBO namespace: mouse_pathology.ontology

mastitis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology

mastocytosis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology
has exact synonym: Urticaria pigmentosa

metritis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology

osteomyelitis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology

psoriasiform dermatitis
type: Class
subclass of: dermatitis
has OBO namespace: mouse_pathology.ontology

nephritis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology

pyelonephritis
type: Class
subclass of: nephritis
has OBO namespace: mouse_pathology.ontology

septic nephritis
type: Class
subclass of: nephritis
has OBO namespace: mouse_pathology.ontology

urocystitis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology

diverticulum
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has definition: A blind ended outpouching through the wall of a tubular organ or bounded cavity.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

septic urocystitis
type: Class
subclass of: urocystitis
has OBO namespace: mouse_pathology.ontology

septicemia
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology

arteritis
type: Class
subclass of: vasculitis
has OBO namespace: mouse_pathology.ontology

degenerative arthritis
type: Class
subclass of: arthritis
subclass of: tissue specific degenerative process
subclass of: arthropathy
has OBO namespace: mouse_pathology.ontology

arthropathy
type: Class
subclass of: tissue specific degenerative process
subclass of: lingual adenitis
has OBO namespace: mouse_pathology.ontology

accessory organ
type: Class
subclass of: supernumerary structure
has OBO namespace: mouse_pathology.ontology

amputation
type: Class
subclass of: displacement and deformity
has OBO namespace: mouse_pathology.ontology

autoamputation
type: Class
subclass of: amputation
has OBO namespace: mouse_pathology.ontology

aortitis
type: Class
subclass of: vasculitis
has OBO namespace: mouse_pathology.ontology

lymphangitis
type: Class
subclass of: vasculitis
has OBO namespace: mouse_pathology.ontology

ectopia
type: Class
subclass of: ObsoleteClass
comment: obsolete - Subsumed into heterotopia MPATH:76
has OBO namespace: mouse_pathology.ontology
has definition: ectopia
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

phlebitis
type: Class
subclass of: vasculitis
has OBO namespace: mouse_pathology.ontology

pustule
type: Class
subclass of: abscess
has OBO namespace: mouse_pathology.ontology
has exact synonym: cutaneous abscess

ulcerative blepharitis
type: Class
subclass of: blepharitis
has OBO namespace: mouse_pathology.ontology

pyometra
type: Class
subclass of: metritis
has OBO namespace: mouse_pathology.ontology

acidophilic anterior pituitary gland adenoma
type: Class
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology

spindle cell sarcoma
type: Class
subclass of: sarcoma
has OBO namespace: mouse_pathology.ontology

spindle cell hyperplasia
type: Class
subclass of: hyperplastic tissue
has OBO namespace: mouse_pathology.ontology

alopecia areata
type: Class
subclass of: alopecia
has OBO namespace: mouse_pathology.ontology

exostosis
type: Class
subclass of: growth and differentiation defect
has OBO namespace: mouse_pathology.ontology

ankylosing exostosis
type: Class
subclass of: exostosis
has OBO namespace: mouse_pathology.ontology

coagulation necrosis
type: Class
subclass of: necrosis
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: A type of necrosis in which the affected cells or tissue are reduced to homogeneous eosinophilic mass without nuclear staining, as a result of the protein coagulation, eg. Infarct. Tissue architecture persists.
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

fistula
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has definition: An abnormal passage between two internal organs or leading from a cavity to the body surface.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

ascites
type: Class
subclass of: intracellular and extracellular accumulation
has OBO namespace: mouse_pathology.ontology

developmental aspermia
type: Class
subclass of: developmental process abnormalities
has OBO namespace: mouse_pathology.ontology

acquired aspermia
type: Class
subclass of: defective growth and differentiation process
has OBO namespace: mouse_pathology.ontology

developmental hypoplasia
type: Class
subclass of: developmental process abnormalities
has OBO namespace: mouse_pathology.ontology

thyroiditis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology

acinar atrophy
type: Class
subclass of: atrophy
has OBO namespace: mouse_pathology.ontology

cryptorchidism
type: Class
subclass of: organ specific developmental defect
has OBO namespace: mouse_pathology.ontology

angiolipoma
type: Class
subclass of: lipomatous tumor
has OBO namespace: mouse_pathology.ontology

pyelectasia
type: Class
subclass of: intracellular and extracellular accumulation
comment: May be fetal or adult.
has OBO namespace: mouse_pathology.ontology
has definition: Distension of the renal pelvis by accumulated fluid or urine.
  type: Definition
  has db xref: NULL:NULL
    type: DbXref
    has URI: http://purl.org/obo/owl/NULL#NULL_NULL

alveolar rhabdomyosarcoma
type: Class
subclass of: rhabdomyosarcoma
has OBO namespace: mouse_pathology.ontology
has definition: Malignant tumor of striated muscle or pluripotential mesenchymal stem cells composed mainly of small round cells, with some partial skeletal muscle differentiation.
  type: Definition
  has db xref: ICD-O:8920/3
    type: DbXref
    has URI: http://purl.org/obo/owl/ICD-O#ICD-O_8920/3

fusion defect
type: Class
subclass of: developmental process abnormalities
has OBO namespace: mouse_pathology.ontology
has definition: Failure of two or more structures ( not voids or lumens) to join together.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

embryonal rhabdomyosarcoma
type: Class
subclass of: rhabdomyosarcoma
comment: Includes spindle cell, botryoid, anaplastic.
has OBO namespace: mouse_pathology.ontology
has definition: Malignant mesenchymal tumor that morphologically and phenotypically resembles embryonal skeletal muscle.
  type: Definition
  has db xref: ICDO-:8912/3
    type: DbXref
    has URI: http://purl.org/obo/owl/ICDO-#ICDO-_8912/3
  has db xref: ICD-O:8910/3
    type: DbXref
    has URI: http://purl.org/obo/owl/ICD-O#ICD-O_8910/3
has related synonym: Rhabdopoietic Sarcoma
has related synonym: Sarcoma Botryoides [Soft Tissues]
has exact synonym: Myosarcoma
has related synonym: Embryonal Sarcoma
has related synonym: Malignant Rhabdomyoma

situs ambiguus
type: Class
subclass of: left/right axis defect
has OBO namespace: mouse_pathology.ontology

heterotaxy
type: Class
subclass of: left/right axis defect
has OBO namespace: mouse_pathology.ontology

situs ambiguus totalis
type: Class
subclass of: situs inversus
has OBO namespace: mouse_pathology.ontology
has db xref: XX:<new_dbxref>
  type: DbXref
  has URI: http://purl.org/obo/owl/XX#XX_<new_dbxref>
has related synonym: situs inversus with dextrocardia

situs inversus with levocardia
type: Class
subclass of: situs inversus
has OBO namespace: mouse_pathology.ontology

sinusitis
type: Class
subclass of: inflammation
has OBO namespace: mouse_pathology.ontology

ciliary motility defect
type: Class
subclass of: subcellular defect
has OBO namespace: mouse_pathology.ontology
has related synonym: primary ciliary dyskinesis

sequestrum
type: Class
subclass of: cell and tissue damage
comment: Most often used in the context of bone.
has OBO namespace: mouse_pathology.ontology

pre-sacral teratoma
type: Class
subclass of: teratoma
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Pre-sacral tumors located in the retrorectal space between the rectum and the sacrococcygeal part of the spine.
  has db xref: NULL:NULL
    type: DbXref
    has URI: http://purl.org/obo/owl/NULL#NULL_NULL

bronchiectasia
type: Class
subclass of: ectasia
has OBO namespace: mouse_pathology.ontology

growth acceleration
type: Class
subclass of: developmental process abnormalities
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Increase in the rate of growth of an organism, organ or tissue as a consequence of increased proliferation, reduced cell death, or a combination. Not due to an increase in cell size; see Hypertrophy MPATH: 159.
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

situs inversus
type: Class
subclass of: left/right axis defect
has OBO namespace: mouse_pathology.ontology

Sacrococcygeal teratoma
type: Class
subclass of: teratoma
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Sacrococcygeal tumors are located at the base of the coccyx.
  has db xref: NULL:NULL
    type: DbXref
    has URI: http://purl.org/obo/owl/NULL#NULL_NULL

rhabdomyoma
type: Class
subclass of: sarcoma
comment: Adult and fetal types.
has OBO namespace: mouse_pathology.ontology
has definition: Benign stromal tumors of the soft tissue with skeletal muscle differentiation.
  type: Definition
  has db xref: PMID:3525381
    type: DbXref
    has URI: http://purl.org/obo/owl/PMID#PMID_3525381
  has db xref: ICD-O:M-8900/0
    type: DbXref
    has URI: http://purl.org/obo/owl/ICD-O#ICD-O_M-8900/0

fibromatosis
type: Class
subclass of: fibroma
has OBO namespace: mouse_pathology.ontology
has exact synonym: Desmoid Tumor
has related synonym: Plantar Fibromatosis (Ledderhose Disease)
has definition: Systemic manifestation of MPATH: 407.
  type: Definition
  has db xref: ICDO:M-8822/1
    type: DbXref
    has URI: http://purl.org/obo/owl/ICDO#ICDO_M-8822/1
has related synonym: Musculoaponeurotic Fibromatosis
has related synonym: Aggressive Fibromatosis

xanthoma
type: Class
subclass of: lipid deposition
has OBO namespace: mouse_pathology.ontology
has definition: Dermal, subcutaneous, or tendinous lesions characterized by accumulations of lipid-laden macrophages often rich in cholesterol.
  type: Definition
  has db xref: MPATH:Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/MPATH#MPATH_Pathology_Committee

chronic interstitial nephritis
type: Class
subclass of: interstitial nephritis
has OBO namespace: mouse_pathology.ontology

hemosiderosis
type: Class
subclass of: iron deposition
has OBO namespace: mouse_pathology.ontology

hepatic hemosiderosis
type: Class
subclass of: hemosiderosis
has OBO namespace: mouse_pathology.ontology

pulmonary hemosiderosis
type: Class
subclass of: hemosiderosis
has OBO namespace: mouse_pathology.ontology

splenic melanosis
type: Class
subclass of: melanin deposition
has OBO namespace: mouse_pathology.ontology

growth arrest
type: Class
subclass of: developmental process abnormalities
has OBO namespace: mouse_pathology.ontology
has definition: The cessation of fetal or embryonic growth beyond a particular stage.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

renal tubular concretion
type: Class
subclass of: concretion
has OBO namespace: mouse_pathology.ontology

Leydig cell hyperplasia
type: Class
subclass of: hyperplastic tissue
has OBO namespace: mouse_pathology.ontology

tracheal gland ectasia
type: Class
subclass of: ectasia
has OBO namespace: mouse_pathology.ontology

mucometra
type: Class
subclass of: mucous secretions
has OBO namespace: mouse_pathology.ontology
has definition: A uterus distended with a fluid containing large quantities of mucin.
  type: Definition
  has db xref: MPATH:Sundberg
    type: DbXref
    has URI: http://purl.org/obo/owl/MPATH#MPATH_Sundberg

acute blepharitis
type: Class
subclass of: blepharitis
has OBO namespace: mouse_pathology.ontology

molar hypercementosis
type: Class
subclass of: intracellular and extracellular accumulation
comment: This is usually a normal adaptive response, serving to improve the functional properties of teeth during aging.
has OBO namespace: mouse_pathology.ontology
has definition: Thickening of the cementum layer of the molars.
  type: Definition
  has db xref: MPATH:Sundberg
    type: DbXref
    has URI: http://purl.org/obo/owl/MPATH#MPATH_Sundberg

ovarian follicular cyst
type: Class
subclass of: cyst
comment: A variety of cysts develop in the ovary. They are subdivided based on where they develop anatomically. Ovarian follicles in this case become large and fluid filled.
has OBO namespace: mouse_pathology.ontology

retinal degeneration
type: Class
subclass of: tissue specific degenerative process
comment: Usually rd6-outer retinal photoreceptor degeneration
has OBO namespace: mouse_pathology.ontology

uterine cystic endometrial hyperplasia
type: Class
subclass of: hyperplasia
comment: The uterus of older female mice often becomes distended with numerous fluid filled cysts that extend from the endometrium.
has OBO namespace: mouse_pathology.ontology

sub-retinal hemorrhage
type: Class
subclass of: hemorrhage and non-specified extravasation
has OBO namespace: mouse_pathology.ontology
has definition: Extravascular blood between retina and choroid
  type: Definition
  has db xref: MPATH:Sundberg
    type: DbXref
    has URI: http://purl.org/obo/owl/MPATH#MPATH_Sundberg

hamartoma
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: A focal malformation resembling a neoplasm which results from faulty development of an organ; composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element. Growth and location are usually normal for that tissue cf. Heterotopia/Choristoma MPATH:76/MPATH:477.
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

drusen
type: Class
subclass of: protein deposition
has OBO namespace: mouse_pathology.ontology
has definition: Tiny yellow or white deposits of lamellar or amorphous extracellular material that build up between retina and retinal pigment epithelium.
  type: Definition
  has db xref: MPATH:Sundberg
    type: DbXref
    has URI: http://purl.org/obo/owl/MPATH#MPATH_Sundberg

splenomegaly
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has definition: An increase in size of the spleen.
  type: Definition
  has db xref: MPATH:Sundberg
    type: DbXref
    has URI: http://purl.org/obo/owl/MPATH#MPATH_Sundberg

intervertebral disk prolapse
type: Class
subclass of: prolapse
comment: These become more common with age.
has OBO namespace: mouse_pathology.ontology
has definition: Rupture of the intervertebral disc, usually dorsally to compress the spinal cord, secondary to trauma.
  type: Definition
  has db xref: MPATH:Sundberg
    type: DbXref
    has URI: http://purl.org/obo/owl/MPATH#MPATH_Sundberg

hepatic centrolobular fatty metamorphosis
type: Class
subclass of: steatosis
has OBO namespace: mouse_pathology.ontology
has definition: Accumulation of clear large vacuoles in hepatocytes (most likely lipid pending frozen sections and oil red O or other lipid stains) around central veins.
  type: Definition
  has db xref: MPATH:Sundberg
    type: DbXref
    has URI: http://purl.org/obo/owl/MPATH#MPATH_Sundberg

pigmentary incontinence
type: Class
subclass of: intracellular and extracellular depletion
comment: Observed as melanin pigment within macrophages in the dermis. Inflammation in the epidermis stimulates melanocytes to increase the synthesis of melanin and subsequently to transfer the pigment to surrounding keratinocytes. If the basal layer is injured (e.g. lichen planus), melanin pigment is released and subsequently trapped by macrophages in the papillary dermis.
has OBO namespace: mouse_pathology.ontology
has definition: Release of melanin pigment in the dermis.
  type: Definition
  has db xref: MPATH:Sundberg
    type: DbXref
    has URI: http://purl.org/obo/owl/MPATH#MPATH_Sundberg

zenker's necrosis
type: Class
subclass of: necrosis
has OBO namespace: mouse_pathology.ontology
has definition: Degenerative changes in skeletal muscle including hyalinization, swelling, fragmentation, vacuolation eventually resulting in death of muscle fibers.
  type: Definition
  has db xref: MPATH:Sundberg
    type: DbXref
    has URI: http://purl.org/obo/owl/MPATH#MPATH_Sundberg

cartilagenous erosion
type: Class
subclass of: tissue specific degenerative process
has OBO namespace: mouse_pathology.ontology
has definition: Fragmentation and erosion of articular cartilage.
  type: Definition
  has db xref: MPATH::Sundberg
    type: DbXref
    has URI: http://purl.org/obo/owl/MPATH#MPATH_:Sundberg

renal tubular amyloidosis
type: Class
subclass of: amyloid deposition
has OBO namespace: mouse_pathology.ontology
has definition: Pink amorphous material (amyloid) deposited within the renal tubules.
  type: Definition
  has db xref: MPATH:Sundberg
    type: DbXref
    has URI: http://purl.org/obo/owl/MPATH#MPATH_Sundberg

recanalised thrombus
type: Class
subclass of: thrombosis
has OBO namespace: mouse_pathology.ontology
has definition: An old organized thrombus that has been recanalized to permit blood flow.
  type: Definition
  has db xref: MPATH:Sundberg
    type: DbXref
    has URI: http://purl.org/obo/owl/MPATH#MPATH_Sundberg

focal pulmonary fibrosis
type: Class
subclass of: fibrosis
has OBO namespace: mouse_pathology.ontology
has definition: Various degrees of pulmonary interstitial fibrosis.
  type: Definition
  has db xref: MPATH:Sundberg
    type: DbXref
    has URI: http://purl.org/obo/owl/MPATH#MPATH_Sundberg

hernia
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has definition: Protrusion of a loop or wall of an organ through an abnormal opening.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

pulmonary adenomatosis
type: Class
subclass of: adenoma
has OBO namespace: mouse_pathology.ontology
has definition: Neoplastic proliferation of cuboidal cells lining alveoli most likely type II pneumocytes.
  type: Definition
  has db xref: MPATH:Sundberg
    type: DbXref
    has URI: http://purl.org/obo/owl/MPATH#MPATH_Sundberg

pigment dispersion
type: Class
subclass of: intracellular and extracellular depletion
has OBO namespace: mouse_pathology.ontology
has definition: Free pigment in anterior chamber/elsewhere in eye.
  type: Definition
  has db xref: MPATH:Sundberg
    type: DbXref
    has URI: http://purl.org/obo/owl/MPATH#MPATH_Sundberg

barbered
type: Class
subclass of: developmental or adult structural defect
comment: This is a form of trichotillomania.
has OBO namespace: mouse_pathology.ontology
has definition: loss of hair resulting from a behavioral abnormality in which the mouse, or more often other mice mice in the same box, remove hairs, initially vibrissae, from each other.
  type: Definition
  has db xref: MPATH:Sundberg
    type: DbXref
    has URI: http://purl.org/obo/owl/MPATH#MPATH_Sundberg

gastric forestomach papillomatous hyperplasia
type: Class
subclass of: epithelial hyperplasia
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: The forestomach of the mouse is lined by stratified squamous epithelia. At the limiting ridge there is hyperplasia to various degrees in which this epithelium proliferates to form raised areas on thin fibrovascular stalks.
  has db xref: MPATH:Sundberg
    type: DbXref
    has URI: http://purl.org/obo/owl/MPATH#MPATH_Sundberg

heterotopia
type: Class
subclass of: displacement and deformity
has OBO namespace: mouse_pathology.ontology
has definition: Congenital appearance of a body part or tissue or cell type in a region where it is not normally found ( topographical anomaly).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee
has related synonym: Ectopia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

homoeotic change
type: Class
subclass of: developmental process abnormalities
has OBO namespace: mouse_pathology.ontology
has definition: Definition
  label: Stricto sensu: replacement of one body part or tissue by an homologous structure or tissue, but commonly used incorrectly to describe non-homologous transformations better described as heterotopias or ectopias.
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

incomplete closure
type: Class
subclass of: developmental process abnormalities
has OBO namespace: mouse_pathology.ontology
has definition: Incomplete closure of a void or lumen due to failure of growth or fusion of bounding walls.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

malposition
type: Class
subclass of: heterotopia
has OBO namespace: mouse_pathology.ontology
has definition: Abnormal position or orientation of a structure insufficient to be called a heterotopia.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Misplacement
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

fat necrosis
type: Class
subclass of: necrosis
has OBO namespace: mouse_pathology.ontology
has definition: Dead and dying adipose tissue, characterized by the formation of small gray or white foci of soapy (saponified) cellular debris.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

obstruction and stenosis
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has definition: Occlusion ( partial or complete) of a lumen or space, internally by a space occupying mass or, in the case of stenosis, by local reduction in the diameter of a vessel, duct or the intestine.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

perforation
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has definition: Presence of a hole/channel through a normally imperforate structure often a membrane or septum.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

persistent embryonic structure
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has related synonym: Embryonic rest.
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Persistence of an embryonic structure or tissue into the post-natal period in its normal location; (Chronological/temporal anomaly).
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

septation defect
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has definition: Any defect in the formation of septae not describable as perforation.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

supernumerary structure
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has definition: Additional structure whether normally located or not.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

transdifferentiation
type: Class
subclass of: developmental process abnormalities
comment: This term is generally used in the context of embryonic cells or stem cells.
has OBO namespace: mouse_pathology.ontology
has definition: Alteration in the differentiation of a cell or tissue already showing a different, recognisable, differentiated state.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

organ specific developmental defect
type: Class
subclass of: developmental and structural abnormality
has OBO namespace: mouse_pathology.ontology
has definition: Developmental defect characteristic of a particular organ or organ system which may be a recognised syndrome or a complex defect showing multiple manifestations.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

germ cell defect
type: Class
subclass of: organ specific developmental defect
has OBO namespace: mouse_pathology.ontology
has definition: Abnormal morphology, differentiation or location of primordial germ cells or their descendents. Not neoplastic.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

nephroblastomatosis
type: Class
subclass of: ObsoleteClass
comment: Obsolete - subsumed into MPATH:82
has OBO namespace: mouse_pathology.ontology
has definition: nephroblastomatosis
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

cardiovascular developmental defect
type: Class
subclass of: organ specific developmental defect
has OBO namespace: mouse_pathology.ontology
has definition: Abnormal development of the heart or vascular tissue resulting in morphological abnormality.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

fibrinoid necrosis
type: Class
subclass of: necrosis
comment: Frequently occurs in the walls of blood vessels and in connective tissue in diseases such as disseminated Lupus erythrematosis and polyarteritis nodosa, scleroderma, dermatomyositis and rheumatic fever.
has OBO namespace: mouse_pathology.ontology
has definition: Necrosis in which the necrotic tissue shows deeply eosinophilic staining similar to that of fibrin.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

aneurysm
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has definition: Localised dilation of an artery or heart chamber usually due to an acquired or congenital weakness of the wall of the artery or chamber.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

arteriovenous anastomosis
type: Class
subclass of: cardiovascular developmental defect
has OBO namespace: mouse_pathology.ontology
has related synonym: arteriolovenular anastomosis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: anastomosis arteriovenosa
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: Formation of vessels between arterioles and venules bypassing capillary circulation.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: Anastomosis arteriolovenularis
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

cardiac defect
type: Class
subclass of: cardiovascular developmental defect
has OBO namespace: mouse_pathology.ontology
has definition: Structural, organisational or growth related defects in cardiac development.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has related synonym: heart abnormalities
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

cardiac septation defect
type: Class
subclass of: cardiac defect
has OBO namespace: mouse_pathology.ontology
has definition: Abnormality in the wall between the atria or ventricles, or defects in the truncoconal septum, of the heart; usually incomplete closure.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

valve defect
type: Class
subclass of: cardiac defect
has OBO namespace: mouse_pathology.ontology
has definition: Malformation of the membranous folds of the heart that prevent reflux of fluid.
  type: Definition
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

hypertrophic ventricle
type: Class
subclass of: cardiac defect
has OBO namespace: mouse_pathology.ontology
has definition: Thickening of the wall of one or both of the heart ventricles.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

hypoplastic ventricle
type: Class
subclass of: cardiac defect
has OBO namespace: mouse_pathology.ontology
has definition: Reduction in cell number of one or both of the two lower chambers of the heart.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee

dissecting aneurysm
type: Class
subclass of: aneurysm
has OBO namespace: mouse_pathology.ontology
has definition: Follows the presence of a hematoma in the wall of an artery Splitting of the media occurs, blood enters the split through a tear in the intima.
  type: Definition
  has db xref: ISBN:0781727286
    type: DbXref
    has URI: http://purl.org/obo/owl/ISBN#ISBN_0781727286

lymphangiectasis
type: Class
subclass of: ectasia
subclass of: cardiovascular developmental defect
has OBO namespace: mouse_pathology.ontology
has related synonym: telangiectasia lymphatica
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation
has definition: A stretching and widening of the lymphatic vessels.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee
has related synonym: Lymphectasia
  type: Synonym
  has db xref: Pathbase:_Curation
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Curation

varices
type: Class
subclass of: developmental or adult structural defect
has OBO namespace: mouse_pathology.ontology
has definition: An enlarged and often tortuous vein.
  type: Definition
  has db xref: Pathbase:_Pathology_Committee
    type: DbXref
    has URI: http://purl.org/obo/owl/Pathbase#Pathbase__Pathology_Committee