Left Ventricular Diastolic Myocardial Stiffness and End−Diastolic Myofibre Stress in Human Heart Failure Using Personalised Biomechanical Analysis
Zhinuo J. Wang‚ Vicky Y. Wang‚ Chris P. Bradley‚ Martyn P. Nash‚ Alistair A. Young and J. Jane Cao
Abstract
Understanding the aetiology of heart failure with preserved (HFpEF) and reduced (HFrEF) ejection fraction requires knowledge of biomechanical factors such as diastolic myocardial stiffness and stress. Cine CMR images and intra-ventricular pressure recordings were acquired in 8 HFrEF, 11 HFpEF and 5 control subjects. Diastolic myocardial stiffness was estimated using biomechanical models and found to be greater in HFrEF (6.4þinspace\textpmþinspace1.2 kPa) than HFpEF (2.7þinspace\textpmþinspace0.6 kPa, pþinspaceþinspace0.05). Personalised biomechanical analysis may provide more specific information about myocardial mechanical behaviour than global chamber indices, which are confounded by variations in ventricular geometry.