Latest News

Interested in joining us for a DPhil/PhD in Oxford Computational Cardiovascular Science?

Posted 11/11/2021

Several routes listed below. Please read through requirements, check alignment with our latest publications and research programme, and send your application before the deadline:

Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility

Posted 11/11/2021

Musuamba FT, Skottheim Rusten I, Lesage R, Russo G, Bursi R, Emili L, Wangorsch G, Manolis E, Karlsson KE, Kulesza A, Courcelles E, Boissel JP, Rousseau CF, Voisin EM, Alessandrello R, Curado N, Dall'ara E, Rodriguez B, Pappalardo F, Geris L. CPT Pharmacometrics Syst Pharmacol, 2021. doi: 10.1002/psp4.12669.

Comparison of the Simulated Response of Three in Silico Human Stem Cell-Derived Cardiomyocytes Models and in Vitro Data Under 15 Drug Actions

Posted 16/06/2021
Paci M, Passini E, Klimas A, Severi S, Hyttinen J, Rodriguez B, Entcheva E. In Silico hiPSC Cardiomyocytes: Front Pharmacol (2021). doi: 10.3389/fphar.2021.604713

Inference of ventricular activation properties from non-invasive electrocardiography

Posted 16/07/2021
Camps J, Lawson B, Drovandib C, Minchole A, Wanga Z J, Graud V, Burragea K, Rodriguez B. Medical Image Analysis, 2021, 1361-1376

A Completely Automated Pipeline for 3D Reconstruction of Human Heart from 2D Cine MR Slices

Posted 16/06/2021
Banerjee A, Camps J, Zacur E, Choudhury R P, Rodriguez B, Grau V. Philosophical Transactions of the Royal Society, 2021. doi: 10.1098/rsta.2020.0257

Best poster presentation at FiMH 2021

Posted 16/06/2021
Alfonso Beuno-Orovio in collaboration with Rafa Sebastian's group received the best post presentation award at FiMH 2021. Take a look (limited free access until end of July.

The Rosanna Degani Young Investigator Finalist Award at CinC 2021

Posted 16/06/2021
Francesca Margara awarded Finalist award of the CinC Rosanna Degani Young Investigator Award

The Rosanna Degani Young Investigator Semi-Finalist Awards at CinC 2021

Posted 16/06/2021
Julia Camps and James Coleman both were Semi-Finalists of the CinC 2021 Rosanna Degani Young Investigator Award.

EPSRC Doctoral Award

Posted 16/06/2021
Julia Camps has been awarded an EPSRC Doctoral Prize to increase the impact of his PhD, entitled Bayesian inference and Machine learning methods for the advanced analysis of electrocardiographic signals. This prize includes nine months of salary for Julia to stay as a postdoctoral researcher in our group.

Wellcome Trust Sir Henry Wellcome Fellowship awarded to Dr. Jakub Tomek

Posted 16/06/2021

Dr. Jakub Tomek has been awarded the Wellcome Trust Sir Henry Wellcome Fellowship that he will pursue at the University of Oxford and UC Davis, California, focusing on the theme of diabetic arrhythmogenesis.

Diabetes mellitus is a highly prevalent disease and cardiac arrhythmia is among the leading causes of death among diabetic patients. However, the mechanisms of how diabetes contributes to arrhythmogenesis remain highly underresearched, perhaps due to difficulty of clinical and experimental investigation. Jakub will tackle the topic by combining state-of-the-art human-specific computational simulations, focused experimental studies, and analyses of clinical data. The project will improve our understanding of diabetic arrhythmia and aims to lead to population-level and personalised translational applications.

CalTrack: High-Throughput Automated Calcium Transient Analysis in Cardiomyocytes

Posted 16/04/2021
Psaras Y, Margara F, Cicconet M, Sparrow A J, Repetti G G, Schmid M, Steeples V, Wilcox J A L, Bueno-Orovio A, Redwood C S, Watkins H C, Robinson P, Rodriguez B, Seidman J G, Seidman C E, Toepfer C N. Circulation Research 2021; 129:326-341.

Human biventricular electromechanical simulations on the progression of electrocardiographic and mechanical abnormalities in post-myocardial infarction

Posted 16/04/2021
Wang ZJ, Santiago A, Zhou X, Wang L, Margara F, Levrero-Florencio F, Das A, Kelly, C, Dall'Armellina E, Vazquez M, Rodriguez B. EP Europace, Volume 23, (Supplement_1, March 2021, Pages i143–i152.

Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalities - JMCC's "Papers of the Year" of 2020

Posted 04/02/2021

Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalities paper, published in the Journal of Molecular and Cellular Cardiology, has been selected as one of JMCC’s “Papers of the Year” of 2020. 

The article was selected as one of 4 Papers of the Year from among nearly 200 articles published in JMCC last year. The contribution has generated immediate impact in the field of cardiology, and has contributed to JMCC’s status as among the most widely accessed journals in the field.

 JMCC is extremely honored to work with the leading scientists in cardiovascular research and look forward to future contributions.

New Paper - In-silico human electro-mechanical ventricular modelling and simulation for drug-induced pro-arrhythmia and inotropic risk assessment

Posted 18/01/2021

Margara F, Wang Z J, Levrero-Florencio F, Santiago A, Vaquez M, Bueno-Orovio A, Rodriguez B. Progress in Biophysics and Molecular Biology. 2020. DOI: 10.1016/j.pbiomolbio.2020.06.007.

Oxford-Bristol Myers Squibb Fellowship

Posted 16/12/2020
Dr Xin Zhou is awarded the Oxford-Bristol Myers Squibb Fellowship to work on drug target evaluation for the treatment of chronic heart failure. Chronic heart failure is an unmet medical need with a huge health care burden, and it is a major therapeutic area of interest of BMS. The project aims to identify the most promising, safe, and effective targets for heart failure treatment using advanced computer modelling and simulation technology developed at Oxford.

Awards and distinctions to our group at the Computing in Cardiology 2020 Conference

Posted 18/09/2020

Members of our team remotely attended the Computing in Cardiology, Rimini, Italy, 2020 conference this past week and garnered the following awards and distinctions: Finalist placing for the Roanna Degani Young Investigator Award to Hannah Smith MPhys, Semi-finalist placing for the same award to Francesca Margara MSc, and Best Remote Poster Presentation Award to Dr Zhinuo Jenny Wang. We also contributed with oral presentations by Dr Xin Zhou, Dr Cristian Trovato, and a special session oral presentation by Professor Blanca Rodriguez. The research we presented included novel human Purkinje fibre models and electromechanically coupled cell models for drug assessment, investigations of cellular and organ level electromechanical remodelling in post myocardial infarction, and an overview of our progress towards the vision of precision cardiology and the ‘Digital Twin’.  

New paper: The virtual assay software for human in silico drug trials to augment drug cardiac testing

Posted 26/08/2020

Passini E, Zhou X, Trovato C, Britton OJ, Bueno-Orovio A, Rodriguez B. Journal of Computational Science, 2020. DOI 10.1016/j.jocs.2020.101202.

New paper: In silico pace-mapping: prediction of left vs. right outflow tract origin in idiopathic ventricular arrhythmias with patient-specific electrophysiological simulations

Posted 26/08/2020

Doste R, Sebastian R, Francisco Gomez J, Soto-Inglesias D, Alcaine A, Mont L, Berruezo A, Penela D, Camara O. EP Europace July 2020; euaa102. DOI: 10.1093

New paper: In-silico human electro-mechanical ventricular modelling and simulation for drug-induced pro-arrhythmia and inotropic risk assessment

Posted 26/08/2020

Margaraa F, Wanga ZJ, Levrero-Florencioa F, Santiagob A, Vázquezbc M, Bueno-Orovioa A, Rodrigueza B. Progress in Biophysics and Molecular Biology 2020.06.007;  DOI: 10.1016.

New paper: The cardiac sympathetic co-transmitter neuropeptide Y is pro-arrhythmic following ST-elevation myocardial infarction despite beta-blockade

Posted 26/08/2020

Kalla M, Hao G, Tapoulal N, Tomek J, Liu K, Woodward L, Dall’Armellina E, Banning AP, Choudhury RP, Neubauer S, Kharbanda RK, Channon KM, Ajijola OA, Shivkumar K, Paterson DJ, Herring N. European Heart Journal, Volume 41, Issue 23, June 2020, Pages 2168–2179.

New paper: All-Optical Electrophysiology Refines Populations of In Silico Human iPSC-CMs for Drug Evaluation

Posted 03/06/2020

All-Optical Electrophysiology Refines Populations of In Silico Human iPSC-CMs for Drug Evaluation

Michelangelo P, Passini E, Klimas A, Severi S, Hyttinen J, Rodriguez B, Entcheva E. Biophysical Journal; 118(10):2596-2611, 2020. DOI: 10.1016/j.bpj.2020.03.018. Epub 2020 Apr 4.

New paper: Dual Transcriptomic and Molecular Machine Learning Predicts all Major Clinical Forms of Drug Cardiotoxicity

Posted 03/06/2020

Dual Transcriptomic and Molecular Machine Learning Predicts all Major Clinical Forms of Drug Cardiotoxicity. Mamoshina P, Bueno-Orovio A, Rodriguez B. Frontiers in Pharmacology;  2020 10.3389/fpha.2020.00639.

New paper: "Human purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalities

Posted 30/04/2020

Trovato C, Passini E, Nagy N, et al., Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalities, Journal of Molecular and Cellular Cardiology (2019), https://doi.org/10.1016/j.yjmcc.2020.04.001 

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