Human Ventricular Action Potential Models

Tomek et al. 2020 (ToR-ORd-dynCl)

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Journal Paper: ToR-ORd-dynCl: an update of the ToR-ORd model of human ventricular cardiomyocyte with dynamic intracellular chloride
Tomek J, Bueno-Orovio A, Rodriguez B. BioRxiv. 2020.

Tomek et al. 2019 (ToR-ORd)

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Journal Paper: Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block
Tomek J, Bueno-Orovio A, Passini E, Zhou X, Minchole  A, BrittonO, Bartolucci C, Severi S, Shrier A, Virag L, Varro A, Rodriguez B. eLife. 2019.

Chang et al. 2017 (ORd - CiPA version)

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Journal Paper: Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment Chang KC, Dutta S, Mirams GR, Beattie KA, Sheng J, Tran PN, Wu M, Wu WW, Colatsky T, Strauss DG, Li Z. Front Physiol. 2017.

Asakura et al. 2011. 

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Journal Paper: EAD and DAD mechanisms analyzed by developing a new human ventricular cell model
Asakura K, Cha CY, Yamaoka H, Horikawa Y, Memida H, Powell T, Amano A, Noma A. Prog Biophys Mol Bio. 2014.

O’Hara et al. 2011 (ORd)

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Journal Paper: Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation
O’Hara T, Virág L, Varró A, Rudy Y. PLoS Comput Biol. 2011.

Carro et al. 2011. 

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Journal Paper: A human ventricular cell model for investigation of cardiac arrhythmias under hyperkalaemic conditions
Carro J, Rodríguez JF, Laguna P, Pueyo E. Philos T Roy Soc A. 2011.

Grandi et al. 2010 

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Journal Paper: A novel computational model of the human ventricular action potential and Ca transient 
Grandi E, Pasqualini FS, Bers DM. J Mol Cell Cardiol. 2010.  

Grandi et al. 2009

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Journal Paper: Theoretical investigation of action potential duration dependence on extracellular Ca2+ in human cardiomyocytes
Grandi E, Pasqualini FS, Pes C, Corsi C, Zaza A, Severi S. J Mol Cell Cardiol. 2009.

Fink et al. 2008

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Journal Paper: Contributions of HERG K+ current to repolarization of the human ventricular action potential
Fink M, Noble D, Virag L, Varro A, Giles WR. Prog Biophys Mol Bio. 2008.

Ten Tusscher et al. 2006

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Journal Paper: Alternans and spiral breakup in a human ventricular tissue model
Ten Tusscher KHWJ, Panfilov AV. Am J Physiol-Heart C. 2006.

Ten Tusscher et al. 2004

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Journal Paper: A model for human ventricular tissue
Ten Tusscher KHWJ, Noble D, Noble PJ, Panfilov AV. Am J Physiol-Heart C. 2004.

Iyer et al. 2004.

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Journal Paper: A computational model of the human left-ventricular sub-epicardial cellscardial myocyte
Iyer V, Mazhari R, Winslow RL. Biophys  J. 2004.

Priebe et al. 1998

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Journal Paper: Simulation Study of Cellular Electric Properties in Heart Failure
Priebe L, Beuckelmann DJ. Circ Res. 1998.