An Analysis of Deformation Dependent Electromechanical Coupling in the Mouse Heart
Sander Land‚ Steven Niederer‚ Jan Magnus Aronsen‚ Emil K. S. Espe‚ Lili Zhang‚ William E. Louch‚ Ivar Sjaastad‚ Ole M. Sejersted and Nicolas Smith
Abstract
To investigate the effects of the coupling between excitation and contraction on whole-organ function, we have developed a novel biophysically based multiscale electromechanical model of the murine heart. Through comparison with a comprehensive in vivo experimental data set, we show good agreement with pressure and volume measurements at both physiological temperatures and pacing frequencies. ...
ISSN
0022−3751‚ 1469−7793
Journal
The Journal of Physiology
Keywords
Electrical coupling‚ Force−velocity relationship‚ Modelling
Month
may
Year
2012