Computational Cardiovascular Science aims at the combination of computational methods in cardiovascular research to integrate and expand the information extracted from a range of experimental and clinical data including biosignals and medical images.Our group is part of the BHF Centre of Research Excellence at Oxford, and includes scientists based at the Department of Computer Science and the Bioengineering Institute, with strong links with the Departments of Cardiovascular Medicine and Physiology, and established collaborations with clinical and experimental collaborators in academia, hospitals, pharmaceutical companies and regulatory agencies.
Sessions will include Drug development, Therapies in ischemic cardiomyopathy, Sudden cardiac death, Precision medicine, Digital twins and big date and In the clinic and beyond.
The full programme is available here.
If you would like to attend this free Symposium please email Blanca Rodriguez ASAP as spaces in the lecture theatre are limited.
Registration is free (including lunches on both days and dinner on December 5th).
Remodelling of potassium currents underlies arrhythmic action potential prolongation under beta-adrenergic stimulation in hypertrophic cardiomyopathy
Doste R, Coppini R, Bueno-Orovio A. J Mol Cell Cardiol. 2022 Nov; 172:120-131. doi: 10.1016/j.yjmcc.2022.08.361. Epub 2022 Sep 2.
Cross clinical-experimental-computational qualification of in silico drug trials on human cardiac purkinje cells for proarrhythmia risk prediction
Trovato C, Mohr M, Schmidt F, Passini E, Rodriguez B. Front Toxicol. 2022 Oct 5;4:992650. doi: 10.3389/ftox.2022.992650. eCollection 2022.
In-silico drug trials for precision medicine in atrial fibrillation: From ionic mechanisms to electrocardiogram-based predictions in structurally-healthy human atria
Dasí A, Roy A, Sachetto R, Camps J, Bueno-Orovio A, Rodriguez B. Front Physiol. 2022 Sep 15;13:966046. doi: 10.3389/fphys.2022.966046. eCollection 2022.
Understanding and Improving Risk Assessment After Myocardial Infarction Using Automated Left Ventricular Shape Analysis
Corral Acero J, Schuster A, Zacur E, Lange T, Stiermaier T, Backhaus SJ, Thiele H, Bueno-Orovio A, Lamata P, Eitel I, Grau V. JACC Cardiovasc Imaging. 2022 Sep;15(9):1563-1574. doi: 10.1016/j.jcmg.2021.11.027. Epub 2022 Jan 12.
Graph-based homogenisation for modelling cardiac fibrosis
Farquhar ME, Burrage K, Weber Dos Santos R, Bueno-Orovio A, Lawson BAJ. J Comput Phys. 2022 Jun 15; 459: none, doi: 10.1016/j.jcp.2022.111126.
Pharmacological Management of Hypertrophic Cardiomyopathy: From Bench to Bedside
Palandri C, Santini L, Argirò A, Margara F, Doste R, Bueno-Orovio A, Olivotto I, Coppini R. Drugs. 2022 Jun; 82(8):889-912. doi: 10.1007/s40265-022-01728-w. Epub 2022 Jun 13.
Multi-Domain Variational Autoencoders for Combined Modeling of MRI-Based Biventricular Anatomy and ECG-Based Cardiac Electrophysiology
Beetz M, Banerjee A, Grau V. Front Physiol. 2022 Jun 8; 13:886723. doi: 10.3389/fphys.2022.886723. eCollection 2022.
Paradoxical prolongation of QT interval during exercise in patients with hypertrophic cardiomyopathy: cellular mechanisms and implications for diastolic function
Coppini R, Beltrami M, Doste R, Bueno-Orovio A, Ferrantini C, Vitale G, Pioner JM, Santini L, Argirò A, Berteotti M, Mori F, Marchionni N, Stefàno P, Cerbai E, Poggesi C, Olivotto I. Eur Heart J Open. 2022 May 10;2(3): oeac034. doi: 10.1093/ehjopen/oeac034. eCollection 2022 May.
Basic Research Approaches to Evaluate Cardiac Arrhythmia in Heart Failure and Beyond
Cumberland MJ, Riebel LL, Roy A, O'Shea C, Holmes AP, Denning C, Kirchhof P, Rodriguez B, Gehmlich K. Front Physiol. 2022 Feb 7;13:806366. doi: 10.3389/fphys.2022.806366. eCollection 2022.