The research of the Computational Cardiovascular Science group in Hypertrophic Cardiomyopathy, by combining electrocardiogram and imaging data with machine learning and computer simulations, has been highlighted by the Virtual Physiological Human Institute as their very first success story on how computational techniques can revolutionize the knowledge of cardiac diseases and improve patient care. You can read their summary following this link, or read the full paper here.
Other recent works include our clinical translational study on explaining mechanisms of drug action and efficacy in Hypertrophic Cardiomyopathy, that can be found in this link.
Professor Blanca Rodriguez gave a keynote talk on human silico trials in cardiac pharmacology at the IX Annual Meeting of the Italian Chapter of the European Society of Biomechanics (ESB-ITA) held in Bologna, Italy on the 30th of September 2019.
Hector Martinez-Navarro attended the Compbiomed Conference, 25-27 September 2019. He delivered the talk "HPC simulations for in-silico drug trials in humans: therapeutic strategies in acute myocardial ischemia". He also chaired the session "Organ Modelling and Simulation", focused on haemodynamics, and with great presentations by Mirko Bonfanti, Gaia Franzetti and Giulia Luraghi, among others.
4 members of our team (Elisa Passini, Cristian Trovato, Polina Mamoshina and Francesca Margara) attended the Safety Pharmacology Society Annual Meeting 2019 in Barcelona last week, presenting 4 posters and giving 2 oral presentations. We received a total of 4 awards: Student Travel Award to Francesca Margara; Junior Investigator Travel Award to Cristian Trovato; two 3rd places (tie) in the poster competition, to Cristian Trovato and Elisa Passini. Our research was well received and we came back with lots of new ideas on how to apply our computer models to safety pharmacology.
We are looking for two great scientists to join us as postdocs for 3 years from October 2019:
1) Conducting original research under the supervision of Dr Alfonso Bueno, you will be developing personalised human ventricular models, based on multi-modality magnetic resonance and electrocardiographic imaging studies from patients, and conducting high performance computing studies using the personalised models, in order to investigate risk stratification and tailoring of pharmacological therapy.http://www.cs.ox.ac.uk/news/1705-full.html
2) Under the supervision of Professor Blanca Rodriguez (Professor of Computational Medicine) and Doctor Alfonso Bueno-Orovio (BHF Intermediate Fellow), you will have responsibility for carrying out impactful research on atrial fibrillation at the interface of cardiology and computational modelling and simulation science. You will work in close collaboration with our clinical and industrial partners, and other members of the team.http://www.cs.ox.ac.uk/news/1704-full.html
We will support your career development, through supporting your scientific work, and also through attendance to conferences, student supervision and supporting applications for personal fellowships, as appropriate.
Listen to Elisa Passini's interview for "The Naked Scientists" podcast about computer simulations of the human heart:
Elisa Passini has been elected as Junior Research Fellow at Kellogg College in Oxford for 3 years from October 2019.
Over the last two months, we have been fortunate to receive the visit of world-leading scientists including Kevin Burrage, Elizabeth Cherry, Flavio Fenton, Rodrigo Weber, Eleonora Grandi, Rachel Myles, Don Bers and Richard Clayton. Very stimulating!
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