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About us

Our group is part of the BHF Centre of Research Excellence at Oxford, and includes scientists based at the Department of Computer Science and the Bioengineering Institute, with strong links with the Departments of Cardiovascular Medicine and Physiology, and established collaborations with clinical and experimental collaborators in academia, hospitals, pharmaceutical companies and regulatory agencies.

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Awards and distinctions to our group at the Computing in Cardiology 2020 Conference

Posted 18/09/2020

Members of our team remotely attended the Computing in Cardiology, Rimini, Italy, 2020 conference this past week and garnered the following awards and distinctions: Finalist placing for the Roanna Degani Young Investigator Award to Hannah Smith MPhys, Semi-finalist placing for the same award to Francesca Margara MSc, and Best Remote Poster Presentation Award to Dr Zhinuo Jenny Wang. We also contributed with oral presentations by Dr Xin Zhou, Dr Cristian Trovato, and a special session oral presentation by Professor Blanca Rodriguez. The research we presented included novel human Purkinje fibre models and electromechanically coupled cell models for drug assessment, investigations of cellular and organ level electromechanical remodelling in post myocardial infarction, and an overview of our progress towards the vision of precision cardiology and the ‘Digital Twin’.  

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Latest Publications

The ‘Digital Twin’ to enable the vision ofprecision cardiology

J. Corral-Acero, F. Margara, M. Marciniak, C. Rodero, F. Loncaric, Y. Feng, A. Gilbert, J. F. Fernandes, H. A. Bukhari, A. Wajdan, M. V. Martinez, M. S. Santos, M. Shamohammdi, H. Luo, P. Westphal, P. Leeson, P. DiAchille, V. Gurev, M. Mayr, L. Geris, P. Pathmanathan, T. Morrison, R. Cornelussen, F. Prinzen, T. Delhaas, A. Doltra, M. Sitges, E. J. Vigmond, E. Zacur, V. Grau, B. Rodriguez, E. W. Remme, S. Niederer, P. Mortier, K. McLeod, M. Potse, E. Pueyo, A. Bueno-Orovio, and P. Lamata. European Heart Journal (2020). DOI:10.1093/eurheartj/ehaa159.

Sensitivity analysis of a strongly-coupled human-based electromechanical cardiac model: Effect of mechanical parameters on physiologically relevant biomarkers

F. Levrero-Florencio, F. Margara, E. Zacur, A. Bueno-Orovio, Z. J. Wang, A. Santiago, J. Aguado-Sierra, G. Houzeaux, V. Grau, D. Kay, M. Vázquez, R. Ruiz-Baier, B. Rodriguez. Comput. Methods Appl. Mech. Engrg. 361 (2020) 112762. DOI: 10.1016/j.cma.2019.112762.

Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment.
Zhou X, Qu Y, Passini E, Bueno-Orovio A, Liu Y, Vargas H, Rodriguez B. Frontiers in Pharmacology. 2020; 10:1643. doi: 10.3389/fphar.2019.01643.

Development, calibration, and validation of a novel human ventricular myocyte model in health, disease and drug block.
Tomek J, Bueno-Orovio A, Passini E, Zhou X, Mincholé A, Britton O, Bartolucci C, Severi S, Shrier A, Virag L, Varro A, Rodriguez B. 
eLife. 2019 Dec 23; 8. pii: e48890. doi: 10.7554/eLife.48890.

High arrhythmic risk in antero-septal acute myocardial ischemia is explained by increased transmural reentry occurrence.
Martinez-Navarro H, Mincholé A, Bueno-Orovio A, Rodriguez B. Sci Rep. 2019 Nov 14;9(1):16803. doi: 10.1038/s41598-019-53221-2. PMID: 31728039.