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About us

Our group is part of the BHF Centre of Research Excellence at Oxford, and includes scientists based at the Department of Computer Science and the Bioengineering Institute, with strong links with the Departments of Cardiovascular Medicine and Physiology, and established collaborations with clinical and experimental collaborators in academia, hospitals, pharmaceutical companies and regulatory agencies.

Latest News

New paper: All-Optical Electrophysiology Refines Populations of In Silico Human iPSC-CMs for Drug Evaluation

Posted 03/06/2020

All-Optical Electrophysiology Refines Populations of In Silico Human iPSC-CMs for Drug Evaluation

Michelangelo P, Passini E, Klimas A, Severi S, Hyttinen J, Rodriguez B, Entcheva E. Biophysical Journal; 118(10):2596-2611, 2020. DOI: 10.1016/j.bpj.2020.03.018. Epub 2020 Apr 4.

News & Events Archive

Latest Publications

The ‘Digital Twin’ to enable the vision ofprecision cardiology

J. Corral-Acero, F. Margara, M. Marciniak, C. Rodero, F. Loncaric, Y. Feng, A. Gilbert, J. F. Fernandes, H. A. Bukhari, A. Wajdan, M. V. Martinez, M. S. Santos, M. Shamohammdi, H. Luo, P. Westphal, P. Leeson, P. DiAchille, V. Gurev, M. Mayr, L. Geris, P. Pathmanathan, T. Morrison, R. Cornelussen, F. Prinzen, T. Delhaas, A. Doltra, M. Sitges, E. J. Vigmond, E. Zacur, V. Grau, B. Rodriguez, E. W. Remme, S. Niederer, P. Mortier, K. McLeod, M. Potse, E. Pueyo, A. Bueno-Orovio, and P. Lamata. European Heart Journal (2020). DOI:10.1093/eurheartj/ehaa159.

Sensitivity analysis of a strongly-coupled human-based electromechanical cardiac model: Effect of mechanical parameters on physiologically relevant biomarkers

F. Levrero-Florencio, F. Margara, E. Zacur, A. Bueno-Orovio, Z. J. Wang, A. Santiago, J. Aguado-Sierra, G. Houzeaux, V. Grau, D. Kay, M. Vázquez, R. Ruiz-Baier, B. Rodriguez. Comput. Methods Appl. Mech. Engrg. 361 (2020) 112762. DOI: 10.1016/j.cma.2019.112762.

Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment.
Zhou X, Qu Y, Passini E, Bueno-Orovio A, Liu Y, Vargas H, Rodriguez B. Frontiers in Pharmacology. 2020; 10:1643. doi: 10.3389/fphar.2019.01643.

Development, calibration, and validation of a novel human ventricular myocyte model in health, disease and drug block.
Tomek J, Bueno-Orovio A, Passini E, Zhou X, Mincholé A, Britton O, Bartolucci C, Severi S, Shrier A, Virag L, Varro A, Rodriguez B. 
eLife. 2019 Dec 23; 8. pii: e48890. doi: 10.7554/eLife.48890.

High arrhythmic risk in antero-septal acute myocardial ischemia is explained by increased transmural reentry occurrence.
Martinez-Navarro H, Mincholé A, Bueno-Orovio A, Rodriguez B. Sci Rep. 2019 Nov 14;9(1):16803. doi: 10.1038/s41598-019-53221-2. PMID: 31728039.