The Gordon conference on Contemporary Advances and Challenges in Drug Safety Assessment is held on June 10 - 15, 2018.
Delivering safe and effective drugs remains a major challenge in biomedical science. To address this important challenge, the Drug Safety GRC program is designed to span safety science across the development pipeline from target selection and complex systems biology through the patient experience.
Blanca Rodriguez is presenting a talk on "Computational Modeling of Cardiac Adverse Events". Elisa Passini and Crisitan Trovato are preseting posters on “Human In Silico Drug Trials in Diseased Populations Predict Clinical Risk of Torsade de Pointes” and on "In Silico Trials in Human Ventricular and Purkinje Cell Models Predict Safety and Efficacy of 10 Anti-Arrhythmic Drugs".
Distinct ECG phenotypes identified in hypertrophic cardiomyopathy using machine learning associate with arrhythmic risk markers.
A. Lyon, R. Ariga, A Minchole, M. Mahmod, E. Ormondroyd, P. Laguna, N. de Freitas, S. Neubauer, H. Watkins, Blanca Rodriguez. Doi: 10.3389/fphys.2018.00213. 2018.
In silico evaluation of arrhythmia
X. Zhou, A. Bueno-Orovio, B. Rodriguez. Current Opinion in Physiology. 1: 95–103. Doi: 10.1016/j.cophys.2017.11.003. 2017.