The 18th World Congress of Basic and Clinical Pharmacology is taking place on the 01-06 July, 2018 in Kyoto, Japan. Alfonso Bueno is presenting our research on “Prediction of all forms of drug-induced cardiotoxicity by combined transcriptome analysis and machine learning” by Alfonso Bueno-Orovio, Polina Mamoshina and Blanca Rodriguez and “Computational methods for safety pharmacology and anti-arrhythmic drug discovery: Towards in silico clinical trials in human” by Alfonso Bueno-Orovio, Elisa Passini, Oliver J. Britton and Blanca Rodriguez.
Francesc Levrero-Florencio will give a talk on “Effect of Fibre and Sheetlet Distribution on Physiological Models for Heart Contraction” (Francesc Levrero-Florencio, Ricardo Ruiz Baier, Alfonso Bueno-Orovio, Vicente Grau and Blanca Rodriguez) at the World Congress in Computational Mechanics 2018, New York, 22-27 July, 2018.
The 13th World Congress in Computational Mechanics is expected to be one of the largest Computational Mechanics gatherings in the United States, with an expected participation from all parts of the globe, representing multiple sectors, including academia, government and industry.
Blanca Rodriguez is a keynote speaker on “frontiers of simulation and experimentation for personalised cardiovascular management and treatment” and Hector Martinez will give a talk on “Arrhythmogenic mechanisms in silent acute myocardial ischemia”. The Conference will take place at University College London, 19-20 July, 2018.
The International Conference on Machine Learning 2018 (ICML 2018) is a leading international machine learning conference supported by the International Machine Learning Society (IMLS).The 35th ICML 2018 is held in Stockholm, Sweden, Tuesday July 10 - Sunday July 15, 2018.
Julia Camps is presenting the research on “ConvNet-based QRS Multilead Delineator in Electrocardiogram signals” (Julia Camps, Ana Minchole and Blanca Rodriguez).
The Gordon conference on Contemporary Advances and Challenges in Drug Safety Assessment is held on June 10 - 15, 2018.
Delivering safe and effective drugs remains a major challenge in biomedical science. To address this important challenge, the Drug Safety GRC program is designed to span safety science across the development pipeline from target selection and complex systems biology through the patient experience.
Blanca Rodriguez is presenting a talk on "Computational Modeling of Cardiac Adverse Events". Elisa Passini and Crisitan Trovato are preseting posters on “Human In Silico Drug Trials in Diseased Populations Predict Clinical Risk of Torsade de Pointes” and on "In Silico Trials in Human Ventricular and Purkinje Cell Models Predict Safety and Efficacy of 10 Anti-Arrhythmic Drugs".
As part of the CompBioMed project, we are presenting the film “the Virtual Human” followed by a discussion. Roger Highfield talks to Peter Coveney, Ana Mincholé and Andrea Townsend-Nicholson who are bridging the fields of human biology, chemistry and computational science to pioneer the personalised medicine.
Elisa Passini is presenting at the Hay Festival, the 30th of May, a journey into the Virtual Heart to understand how human-based computer models and simulations can be used to predict risk of cardiac side effects in patients taking drugs. This technology shows high accuracy and has the potential to play a major role in the reduction and replacement of animal testing in the early stages of drug development.
The adoption of big data, machine learning, and simulation software in biology and drug discovery have allowed for rapid progress in these fields. So far these technologies have aided discoveries, but can they eventually replace human effort and experiments? Prof. Blanca Rodriguez, Dr. Alina Rakhimova and Dr. Romain Talon will try to answer this question and evaluate the role of computers in the future of biology and medicine.
The talk is held at the Department of Computer Science of the University of Oxford on Wednesday the 23rd of May 2018.
We have published an article on the research we are doing on in silico heart models and the potential this technology has on reducing the use of animals on the drug development process.
Before new medicines reach patients several tests are done to detect possible risks and side effects. This is the reason why drugs are tested on millions of animals worldwide each year. But this landscape is changing: research shows computer simulations of the heart have the potential to improve the drug development process and to reduce the need for animal testing.
Drug development requires a long and costly pipeline, where the drug is tested in a gradually more realistic setting (i.e. the experimental model), where animals are the last step before human volunteers. The challenge is to identify the correct threads for human health, and not to miss the potential risk or value of a drug for example due to the differences between animals and humans.
The revolutionary idea is to test a new drug in a “virtual human”, an experimental model entirely built on the circuits of a computer. Recent research by the our team demonstrates that computational models representing human heart cells show higher accuracy than animal models in predicting adverse drug effects such as dangerous arrhythmias.
This research has recently been awarded with the International 3Rs Prize (from the National Centre for the Replacement Refinement and Reduction of Animals in Research) because of its potential to replace animal testing in labs. Instead of a one-model-fits-all method, the team uses an approach that simulates a wide range of responses under several conditions tested against experimental data. Everyone is different, and some drugs can have harmful side effects only for certain parts of the population, such as people with a specific genetic mutation or disease. This research also won the Technological Innovation Award at the Safety Pharmacology Society Meeting 2017.
Elisa Passini is presenting at the Multiscale modelling in electrophysiology: from atoms to organs workshop in Lugano, March 26- March 28.
This workshop brings together chemists, physicists, engineers and biologists working in different aspects of ion channels with the aim of establishing links and foster collaboration between basic science researchers and those in bioengineering and medicine. Progress in this area will be realized with the availability of suitable computational techniques, and new developments will be covered.
She is presenting the research on “Human multiscale computer models of cardiac electrophysiology for drug safety and efficacy assessment”.
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