News

How can safety pharmacology benefit from human heart disease modelling and simulations?

How can safety pharmacology benefit from human heart disease modelling and simulations?

Posted 05/12/2019
Elisa Passini will deliver a SPS webinar on the 5th of December, giving a comprehensive overview about how computer modelling and simulations can contribute to safety pharmacology.

White paper about Validation Principles for Proarrhythmia Risk Prediction Models now available online

Posted 05/12/2019

The manuscript, published in Clinical Pharmacology and Therapeutics, presents principles for validating proarrhythmia risk prediction models for regulatory use, based on the example of the CiPA paradigm, and it constitutes the results of a combined effort across regulators, industry and academia.

In Silico Human Drug Safety and Efficacy at the Safety Pharmacology Meeting this September in Barcelona

In Silico Human Drug Safety and Efficacy at the Safety Pharmacology Meeting this September in Barcelona

Posted 22/08/2019

Elisa Passini, Cristian Trovato, Francesca Margara and Polina Mamoshina will present their research at the upcoming Safety Pharmacology Society Annual Meeting in Barcelona, together with many of our collaborators. Look out for our posters and presentations!

Simulating a human heart - Elisa Passini's interview for "The Nakes Scientists" now online!

Simulating a human heart - Elisa Passini's interview for "The Nakes Scientists" now online!

Posted 22/08/2019

Listen to Elisa Passini's interview for "The Naked Scientists" podcast about computer simulations of the human heart:

https://www.thenakedscientists.com/articles/interviews/simulating-human-heart

Many visitors and seminars in the last two months!

Many visitors and seminars in the last two months!

Posted 22/08/2019
Over the last two months, we have been fortunate to receive the visit of world-leading scientists including Kevin Burrage, Elizabeth Cherry, Flavio Fenton, Rodrigo Weber, Eleonora Grandi, Rachel Myles, Don Bers and Richard Clayton. Very stimulating!
Elisa Passini at the Safety Pharmacology Society Annual Meeting

Elisa Passini at the Safety Pharmacology Society Annual Meeting

Posted 22/08/2019
Elisa Passini presented our research at the Safety Pharmacology Society 2018 Annual Meeting held in Washington DC, 29th September – 3rd October 2018. Elisa Passini presented a poster on: "Human in silico trials on drug-induced changes in electrophysiology and calcium dynamics, using the Virtual Assay software". Three more posters on our research will be presented by our collaborators from Amgen, Merck and UCB.
Elisa Passini keynote speaker at 3Rs Midlands Symposium

Elisa Passini keynote speaker at 3Rs Midlands Symposium

Posted 22/08/2019
Elisa Passini was the keynote speaker at 3Rs Midlands Symposium on 19th September 2018. Elisa Passini was invited to deliver the keynote lecture at the 3Rs Midlands Symposium 2018, at the University of Birmingham, on our research about the use of computational models of the heart for drug safety and efficacy assessment.
Alfonso Bueno-Orovio presenting at the 18th World Congress of Basic and Clinical Pharmacology

Alfonso Bueno-Orovio presenting at the 18th World Congress of Basic and Clinical Pharmacology

Posted 22/08/2019
The 18th World Congress of Basic and Clinical Pharmacology is taking place on the 01-06 July, 2018 in Kyoto, Japan. Alfonso Bueno is presenting our research on “Prediction of all forms of drug-induced cardiotoxicity by combined transcriptome analysis and machine learning” by Alfonso Bueno-Orovio, Polina Mamoshina and Blanca Rodriguez and “Computational methods for safety pharmacology and anti-arrhythmic drug discovery: Towards in silico clinical trials in human” by Alfonso Bueno-Orovio, Elisa Passini, Oliver J. Britton and Blanca Rodriguez.
VPH Conference 2018

VPH Conference 2018

Posted 29/06/2018

The Virtual Phisiological Human conference 2018 is taking place in Zaragoza, 5-7 September, 2018.

One of the main challenges in the field of Computational Systems Biomedicine is to merge these fields together. The Physiome and Virtual Physiological Human aim to deliver computational modelling frameworks for integrating every level in human biology – one that links genes, proteins, cells and organs to the whole body. Ultimately, the goal of the VPH/Physiome Project is to piece together the complete virtual physiological human: a personalised, 3-D model of an individual’s unique physiological make-up. 

Blanca Rodriguez is a keynote speaker at the Conference. Ana Minchole is giving a talk on “Clinical MRI-based multiscale computational models of heart and torso to investigate the role of anatomy on ECG” and Hector Martinez is presenting the research on “Arrhythmogenic mechanisms in silent acute myocardial ischemia”.

Gordon Conference on Contemporary Advances and Challenges in Drug Safety Assessment

Posted 29/06/2018

The Gordon conference on Contemporary Advances and Challenges in Drug Safety Assessment is held on June 10 - 15, 2018.

Delivering safe and effective drugs remains a major challenge in biomedical science. To address this important challenge, the Drug Safety GRC program is designed to span safety science across the development pipeline from target selection and complex systems biology through the patient experience. 

The computational Cardiovascular Science team took this opportunity to present the latest research on in silico drug trials.