Computational Biology Group

The Computational Biology Group, led by Professor David Gavaghan, is an interdisciplinary group based within the Department of Computer Science. The group engages in theoretical and applied, interdisciplinary and practise-based research at the interface between computer science and the biomedical sciences, focussing on applying computer science and mathematical techniques to clinically and biologically pressing problems. Key applications include physiological modelling (heart, cardiovascular and cardiorespiratory systems, soft tissue mechanics and cancer), biological image and signal analysis, and systems biology. Work is almost entirely done jointly with domain specialists in life sciences and clinical departments. The Computational Biology Group also plays a key role in interdisciplinary initiatives across the University, including the Life Sciences Interface and Systems Biology DTCs which are led by Professor Gavaghan and the BBSRC/EPSRC-funded Centre for Integrative Systems Biology.

Sub-Activities

Related seminar series

People

Faculty	Kevin Burrage David Gavaghan Peter Jeavons David Kay Steve McKeever Blanca Rodriguez Jonathan Whiteley
Visitors	T Alexander Quinn Nic Smith
Research	Rafel Bordas Kelly Burrowes Ramón Casero Cañas Jonathan Cooper Gary Mirams James Osborne Pras Pathmanathan Joe Pitt-Francis Geoff Williams
Students	Valentina Carapella Jonathan Cooper Tom Doel Mandeep Gill Ayush Goyal Katie Leonard Tahir Mansoori Margarita Satraki
Administration	Janet Sadler
Past Members	Miguel Bernabeu Martin Bishop Dan Chen Kathryn Gillow Jack Lee Steven Niederer Michal Plotkowiak James Southern Gareth Stevenson Kirsten Yost

Selected Publications

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Chaste: A test−driven approach to software development for biological modelling

J. Pitt−Francis‚ P. Pathmanathan‚ M.O. Bernabeu‚ R. Bordas‚ J. Cooper‚ A.G. Fletcher‚ G.R. Mirams‚ P. Murray‚ J.M. Osborne‚ A. Walter‚ S.J. Chapman‚ A. Garny‚ I.M.M. van Leeuwen‚ P.K. Maini‚ B. Rodriguez‚ S.L. Waters‚ J.P. Whiteley‚ H.M. Byrne and D.J. Gavaghan

In Computer Physics Communications. Vol. 180. No. 12. Pages 2452−2471. 2009.

Details | BibTeX | DOI (10.1016/j.cpc.2009.07.019)

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk

G. R. Mirams‚ Y. Cui‚ A. Sher‚ M. Fink‚ J. Cooper‚ B. M. Heath‚ N. C. McMahon‚ D. J. Gavaghan and D. Noble

In Cardiovascular Research. Vol. 91. No. 1. Pages 53–61. 2011.

Details | BibTeX | DOI (10.1093/cvr/cvr044)

High−throughput functional curation of cellular electrophysiology models

Niederer S.A. Cooper J. Mirams G.R.

In Progress in Biophysics and Molecular Biology. Vol. 107. Pages 11 − 20. 2011.

Details | BibTeX | DOI (10.1016/j.pbiomolbio.2011.06.003)