Mathematical modelling of the heart: cell to organ
N. P. Smith‚ P. J. Mulquiney‚ M. P. Nash‚ C. P. Bradley‚ D. P. Nickerson and P. J. Hunter
Abstract
Single cell and whole organ mathematical models of cardiac electrophysiology, mechanics and metabolism are presented. The important elements of each model are outlined and, in particular, the methods, techniques and considerations for coupling each element together to create an integrated cardiac model are discussed. Results for both individual tissue and whole organ simulations are presented along with preliminary results from coupled models. (C) 2002 Published by Elsevier Science Ltd.
Details
| Journal |
Chaos Solitons & Fractals |
| Keywords |
enzyme−kinetic equations 2‚3−bisphosphoglycerate metabolism ca2+ dynamics generation currents |
| Note |
517YQ Times Cited:17 Cited References Count:26 |
| Number |
8 |
| Pages |
1613−1621 |
| Volume |
13 |
| Year |
2002 |
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