Metadata−Driven Software for Clinical Trials
Charles Crichton‚ Jim Davies‚ Jeremy Gibbons‚ Steve Harris‚ Andrew Tsui and James Brenton
Abstract
The CancerGrid approach to clinical trials information systems is based on a metamodel developed from the CONSORT statement of best practice in reporting randomised controlled trials. The metamodel is instantiated with metadata elements drawn from a repository, to create a model of a particular clinical trial. The model is then used to derive automatically a trial management system customized for that trial: generating electronic case report forms, configuring randomisation and eligibility services, and parameterising the security subsystem. The key benefits of the approach are a uniform mechanism for trial registration and discovery, reduced cost and rapid implementation of information systems, and shared semantics leading to improved opportunities for meta-analysis. We describe our implementation of this approach, and outline two applications: for a breast cancer study in the UK, and for a rheumatoid arthritis study run by the US Veterans' Health Administration.
Details
| Book Title |
ICSE Workshop on Software Engineering and Health Care |
| Month |
May |
| Year |
2009 |
Links
Related pages
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People |
Charles Crichton | Jim Davies | Jeremy Gibbons | Steve Harris | Pui Wo (Andrew) Tsui |
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Projects |
Accelerating Cancer Research Using Semantics-Driven Technology | CancerGrid | Semantic Frameworks |
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Activities |