interaction of phospholipase A2 with a phospholipid bilayer: Coarse−grained molecular dynamics simulations
CL Wee‚ K. Balali−Mood‚ DJ Gavaghan and MSP Sansom
Abstract
A number of membrane-active enzymes act in a complex environment formed by the interface between a lipid bilayer and bulk water. Although x-ray diffraction studies yield structures of isolated enzyme molecules, a detailed characterization of their interactions with the interface requires a measure of how deeply such a membrane-associated protein penetrates into a lipid bilayer. Here, we apply coarse-grained (
Details
| Journal |
BIOPHYSICAL JOURNAL |
| Keywords |
force−field |
| Number |
4 |
| Pages |
1649–1657 |
| Volume |
95 |
| Year |
2008 |
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