Quiescence as a mechanism for cyclical hypoxia and acidosis
K. Smallbone‚ DJ Gavaghan‚ PK Maini and JM Brady
Abstract
Tumour tissue characteristically experiences fluctuations in substrate supply. This unstable microenvironment drives constitutive metabolic changes within cellular populations and, ultimately, leads to a more aggressive phenotype. Previously, variations in substrate levels were assumed to occur through oscillations in the h ae modynamics of nearby and distant blood vessels. In this paper we examine an alternative hypothesis, that cycles of metabolite concentrations are also driven by cycles of cellular quiescence and proliferation. Using a mathemat
Details
| Journal |
JOURNAL OF MATHEMATICAL BIOLOGY |
| Keywords |
ph |
| Month |
Nov |
| Number |
5 |
| Pages |
767–779 |
| Volume |
55 |
| Year |
2007 |
Links
Related pages
|
People |