Metabolic changes during carcinogenesis: Potential impact on invasiveness
K. Smallbone‚ RA Gatenby‚ RJ Gillies‚ PK Maini and DJ Gavaghan
Abstract
Successful adaptation to varying microenvironmental constraints plays a crucial role during carcinogenesis. We develop a hybrid cellular automation approach to investigate the cell-microenvironmental interactions that mediate somatic evolution of cancer cells. This allows investigation of the hypothesis that regions of premalignant lesions develop a substrate-limited environment as proliferation carries cells away from blood vessels which remain separated by the intact basement membr
Details
| Journal |
JOURNAL OF THEORETICAL BIOLOGY |
| Keywords |
spheroids |
| Number |
4 |
| Pages |
703–713 |
| Volume |
244 |
| Year |
2007 |
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