Variation of venous admixture‚ SF6 shunt‚ Pa−O2‚ and the Pa−O2/F−IO2 ratio with F−IO2
JP Whiteley‚ DJ Gavaghan and CEW Hahn
Abstract
Background. Measures of impairment of oxygenation can be affected by the inspired oxygen fraction.Methods. We used a mathematical model of an inhomogenous lung to predict the effect of increasing inspired oxygen concentration (FIO2) on: (1) venous admixture ((Q) over dotva/(Q) over dott); (2) arterial oxygen partial pressure (Pa-O2); (3) the Pa-O2/FIO2 index of hypoxaemia; and (4) sulphur hexafluoride (SF6) retention (often taken to be true right-to-left shunt). This model predicts whether or not atelectasis will occur.Results. For lungs with regions of low (V) over dot/(Q) over
Details
| Journal |
British Journal Of Anaesthesia |
| Keywords |
hypoxemia |
| Month |
Jun |
| Number |
6 |
| Pages |
771–778 |
| Publisher |
Oxford University Press |
| Volume |
88 |
| Year |
2002 |
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