EFFECT OF METHYLENE−BLUE ON THE VASODILATOR ACTION OF INHALED NITRIC−OXIDE IN HYPOXIC SHEEP
JD YOUNG‚ OJ DYAR‚ L. XIONG‚ J. ZHANG and D. GAVAGHAN
Abstract
We have examined the effect of methylene blue 4 mg kg(-1) on the pulmonary vasodilator action of inhaled nitric oxide (8, 32, 128 and 512 volumes per million) in nine sheep with pulmonary hypertension induced by hypoxia (Fl(o2) = 0.12). The dose-response to nitric oxide was unchanged by methylene blue, but increased cardiac output was noted (P < 0.01). These results indicate that methylene
Details
| Journal |
British Journal Of Anaesthesia |
| Keywords |
responses |
| Month |
Oct |
| Number |
4 |
| Pages |
511–516 |
| Publisher |
Oxford University Press |
| Volume |
73 |
| Year |
1994 |
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