Lipid bilayer deformation and the free energy of interaction of a Kv channel gating−modifier toxin
CL Wee‚ DJ Gavaghan and MSP Sansom
Abstract
A number of membrane proteins act via binding at the water/lipid bilayer interface. An important example of such proteins is provided by the gating-modifier toxins that act on voltage-gated potassium (Kv) channels. They are thought to partition to the headgroup region of lipid bilayers, and so provide a good system for probing the nature of interactions of a protein with the water/bilayer interface. We
Details
| Journal |
Biophysical Journal |
| Keywords |
phospholipid−bilayer |
| Number |
8 |
| Pages |
3816–3826 |
| Publisher |
Biophysical Society |
| Volume |
95 |
| Year |
2008 |
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