role of the Na+/Ca2+ exchangers in Ca2+ dynamics in ventricular myocytes
AA Sher‚ PJ Noble‚ R. Hinch‚ DJ Gavaghan and D. Noble
Abstract
The role of the Na+/Ca2+ exchanger (NCX) as the main pathway for Ca2+ extrusion from ventricular myocytes is well established. However, both the role of the Ca2+ entry mode of NCX in regulating local Ca2+ dynamics and the role or the Ca2+ exit mode during the majority of the physiological action potential (AP) are subjects of controversy. The functional significance of NCXs location in T-tubules and potential co-l
Details
| Journal |
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY |
| Keywords |
induced release |
| Month |
00 |
| Number |
1 |
| Pages |
377–398 |
| Volume |
96 |
| Year |
2008 |
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