role of acidity in solid tumour growth and invasion
K. Smallbone‚ DJ Gavaghan‚ RA Gatenby and PK Maini
Abstract
Acidic pH is a common characteristic of human tumours. It has a significant impact on tumour progression and response to therapies. In this paper, we develop a simple model of three-dimensional tumour growth to examine the role of acidosis in the interaction between normal and tumour cell populations. Both vascular and avascular tumour dynamics are investigated, and a number of different behaviours are observed. Whilst an avascular tumour always proceeds to a benign steady state, a vascular tumour may display either benign or invasive
Details
| Journal |
Journal of theoretical biology |
| Keywords |
cells |
| Number |
4 |
| Pages |
476–484 |
| Publisher |
Elsevier Science |
| Volume |
235 |
| Year |
2005 |
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