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A model of cardiac cellular electromechanics

D. P. Nickerson‚ N. P. Smith and P. J. Hunter

Abstract

A coupled electromechanics model of a single cardiac cell is used to interpret a wide variety of experimental tests and is compared to a limited extent (since no other cardiac model dealing with the full range of mechanical tests is available) with other models of myofilament mechanics. We consider the passive elasticity of the cell, troponin-C-calcium binding kinetics, thin filament kinetics, the length dependence of steady-state tension, cross-bridge kinetics, and the coupling of mechanics to cell electrophysiology (the Noble 98 model) via the calcium transient.

Journal
Philosophical Transactions of the Royal Society of London Series a−Mathematical Physical and Engineering Sciences
Keywords
cardiac electromechanics mathematical modelling cellular mechanics intracellular calcium sarcomere−length muscle force contraction tension titin deactivation transients mechanisms
Note
443TM Times Cited:24 Cited References Count:40
Number
1783
Pages
1159−1172
Volume
359
Year
2001