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Transmural electrophysiological heterogeneities in action potential duration increase the upper limit of vulnerability

T. Maharaj‚ B. Rodriguez‚ R. Blake‚ N. A. Trayanova and D. J. Gavaghan

Abstract

Transmural dispersion in action potential duration (APD) has been shown to contribute to arrhythmia induction in the heart. However, its role in termination of lethal arrhythmias by defibrillation shocks has never been examined. The goal of this study is to investigate how transmural dispersion in APD affects cardiac vulnerability to electric shocks, in an attempt

Journal
Conf Proc IEEE Eng Med Biol Soc  
Keywords
ventricular fibrillation
Pages
4043–6
Volume
1
Year
2006