Comparison of Rule−Based and DTMRI−Derived Fibre Architecture in a Whole Rat Ventricular Computational Model

Abstract

The anisotropic electrical conduction within myocardial tissue due to preferential cardiac myocyte orientation (fibre orientation) is known to impact strongly in electrical wavefront dynamics, particularly during arrhythmogenesis. Faithful representation of cardiac fibre architecture within computational cardiac models which seek to investigate such phenomena is thus imperative. Drawbacks in derivation of fibre structure from imaging modalities often render rule-based representations based on a priori knowledge pr