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role of the Na+/Ca2+ exchangers in Ca2+ dynamics in ventricular myocytes

AA Sher‚ PJ Noble‚ R. Hinch‚ DJ Gavaghan and D. Noble

Abstract

The role of the Na+/Ca2+ exchanger (NCX) as the main pathway for Ca2+ extrusion from ventricular myocytes is well established. However, both the role of the Ca2+ entry mode of NCX in regulating local Ca2+ dynamics and the role or the Ca2+ exit mode during the majority of the physiological action potential (AP) are subjects of controversy. The functional significance of NCXs location in T-tubules and potential co-l

Journal
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY    
Keywords
induced release
Month
00
Number
1
Pages
377–398
Volume
96
Year
2008