Kelly Burrowes
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Dr Kelly Burrowes
EPSRC Post-Doctoral Research Fellow
kelly.burrowes@cs.ox.ac.uk
+44 (0) 1865 610807
Wolfson Building, Parks Road, Oxford OX1 3QD |
Interests
My research interest is in the application of anatomically-based computational models to increase our understanding of respiratory physiology. To date, my research has focussed on the pulmonary circulation, however with new projects starting in 2011 my research will begin to encompass modelling ventilation in the airways, gas exchange, with application to the diseases of asthma and COPD.
Respiratory modelling, in particular Physiome and VPH-related respiratory projects, has developed somewhat in the shadows of other physiological areas, such as cardiac and musculo-skeletal modelling. However, the prominence of respiratory disease and the increasing morbidity and mortality of respiratory illnesses such as chronic obstructive pulmonary disease (COPD, currently the fourth biggest killer) provides strong motivation for development within this area.
We have two exciting European projects starting early 2011. These projects are both funded through the Seventh Framework Programme to contribute to the development of a Virtual Physiological Human (VPH), in particular development of a virtual lung. Patient-specific respiratory models investigating ventilation and perfusion relationships and gas exchange in patients with asthma and COPD will be developed, linking in with several industrial, academic and clinical partners across Europe.
The main aspects of our work within this field include:
- Building models from medical data: Deriving species- and patient-specific geometric models from imaging data;
- Analysis of hyperpolarised gas MRI data;
- Simulating ventilation and perfusion distributions within the lung;
- Application of perfusion models to investigate pulmonary embolism and arterial spin labelling MRI measurements;
- Development of airway and ventilation models for application to understanding remodelling in asthma and chronic obstructive pulmonary disease.
- Models of tissue deformation linked to ventilation, perfusion, and gas exchange.
Biography
I obtained an undergraduate degree in Chemical and Materials Engineering(with first class honours) at the University of Auckland, New Zealand. I continued with a PhD in Biomedical Engineering at the Auckland Bioengineering Institute, graduating in 2005. My thesis was on developing a mathematical model of the human pulmonary circulation, supervised by Associate Professor Merryn Tawhai (still a close collaborator) and Professor Peter Hunter. Most recently, I have completed a 3 year post-doctoral fellowship, funded through the EPSRC at the Life Sciences Interface, where I was based here in the Oxford Computational Biology Group.
Selected Publications
| Assessing the impact of micro−embolism size on hemodynamic changes in a spatially−distributed model of the intra−acinar blood vessels M H Tawhai A R Clark K S Burrowes 2010. |
| Contribution of serial and parallel micro−perfusion to spatial variability in pulmonary inter− and intra−acinar blood flow M H Tawhai A R Clark K S Burrowes 2010. |
| Coupling of lung tissue tethering force to fluid dynamics in the pulmonary circulation K S Burrowes and M H Tawhai 2010. |
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