Dr Kelly Burrowes
Since 2001, I have been involved in biomedical engineering research centred around creating patient-based computational models of the respiratory system. My initial work focussed on developing models of the pulmonary circulation and these models have been applied to investigate perfusion distribution and gas exchange during pulmonary embolism and to understand the limitations in magnetic resonance imaging (MRI) of pulmonary perfusion. More recently my research has turned towards simulation of aspects of ventilation and forced expiration with particular application to understanding links between structure-function changes in the obstructive lung diseases of asthma and chronic obstructive pulmonary disease (COPD).My ongoing research goal is to develop efficient novel computational tools - combining mathematical and computational techniques with experimental, imaging and clinical studies - to provide an increased understanding of the pathophysiological mechanisms occurring in obstructive lung and pulmonary vascular diseases. My passion is for the application and translation of computational and image processing techniques to the clinical environment.
Specific active research collaborations include:
- simulating impedance and ventilation in the lung (with Drs Rafel Bordas (Oxford) and Salman Siddiqui (Leciester));
- predicting forced expiration pre- and post-clinical intervention (with Professors Tawhai (Auckland) and Brightling (Leicester) and Dr Kerry Hedges (Auckland));
- application of computational models to understanding the physiological assumption in proton MRI (with Professors Kim Prisk, Rick Buxton, Sue Hopkins (San Diego) and Robb Glenny (Washington));
- developing a multi-scale model of the airway (with Professor Rod Smallwood (Sheffield) and Dr Bindi Brook (Nottingham));
- application of hyperpolarised gas MR images to computational model parameterisation (with Prof Jim Wild (Sheffield), Dr Rafel Bordas (Oxford));
- investigating the impact of BMI on lung density measurements (with Professor Merryn Tawhai and Dr Alys Clark (Auckland));
- developing an educational web application for smoking-related disease and smoking cessation (with Professor Merryn Tawhai and Dr Richard Christie (Auckland)).
Current sources of funding:
- EU Framework 7 (AirPROM, 2011-2016);
- NIH BRP grant (2014-2018).
- EU Framework 7 (Synergy-COPD, 2011-2014);
- EPSRC Post-doctoral Fellowship at the Life Sciences Interface (2007-2010);
- Health Research Council of New Zealand (2009-2012);
- Greenlane Hospital Research and Educational Fund Post-doctoral Scholarship (2005);
- Foundation for Research, Science and Technology PhD Scholarship (2001-2004).
I obtained an undergraduate degree in Chemical and Materials Engineering (with first class honours) at the University of Auckland, New Zealand. I continued with a PhD in Biomedical Engineering at the Auckland Bioengineering Institute, graduating in 2005. My thesis was on developing a mathematical model of the human pulmonary circulation, supervised by Professor Merryn Tawhai (still a close collaborator) and Professor Peter Hunter. I was awarded a 3 year post-doctoral fellowship, funded through the EPSRC at the Life Sciences Interface, where I was based here in the Oxford Computational Biology Group and subsequently was lead PI in Oxford on two large European grants (AirPROM and Synergy-COPD). I am currently based at the University of Auckland as a visiting acedemic.
Dynamic flow characteristics in normal and asthmatic lungs
Burrowes KS Kim M Bordas R Vos W Hartley RA Brightling CE Kay D Grau V
In Int J Numer Methods Biomed Eng. 2015.
A poroelastic model coupled to a fluid network with applications in lung modelling
Lorenz Berger‚ Rafel Bordas‚ Kelly Burrowes‚ Vicente Grau‚ Simon Tavener and David Kay
In International journal for numerical methods in biomedical engineering. 2015.
A combined image−modelling approach assessing the impact of hyperinflation due to emphysema on regional ventilation–perfusion matching
KS Burrowes‚ T Doel‚ M Kim‚ C Vargas‚ J Roca‚ V Grau and D Kay
In Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization. No. ahead−of−print. Pages 1–17. 2015.