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Sara-Jane Dunn

Personal photo - Sara-Jane Dunn
Sara-Jane Dunn
Doctoral Student
Student, Queen's College

Wolfson Building, Parks Road, Oxford OX1 3QD

Interests

Mathematical modelling     --     Cancer     --     Chaste

Colorectal cancer (CRC) is thought to originate via genetic alterations that cause disruption to the dynamics of the crypts of Lieberkuhn, test-tube shaped glands that line the small and large intestine. It is believed that during carcinogenesis,cells accumulate genetic mutations that destabilise cell-cell contacts and disturb division and migration. The resulting abnormal behaviour can increase stress on the walls of the crypt, causing buckling. Such dysplastic crypts can allow the formation of a benign adenoma if mutated cells do not leave the crypt as they should, but rather persist and proliferate in a localised area. Over time and via accumulated mutations, such a growth can progress to a malignant lesion that can break through to the underlying tissue stroma, and so aid metastasis. To provide insight into the tissue-level effects of the initial genetic mutations, a multi-scale model of the crypt with a realistic, deformable geometry is required. My research concerns the development of such a model, and its usefulness as a predictive tool to further the understanding of interactions across spatial scales in the context of CRC.

Selected Publications

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PROCEEDINGS OF THE OXFORD UNIVERSITY COMPUTING LABORATORY STUDENT CONFERENCE 2010

Programme Committee: Sara−Jane Dunn‚ Joe Loughry‚ Ivan Lubenko (chair) and Huy Vu

No. RR−10−22. OUCL. November, 2010.

Modeling Alveolar Volume Changes During Periodic Breathing in Heterogeneously Ventilated Lungs

Jonathan P. Whiteley Sara−Jane Dunn

In Annals of Biomedical Engineering. 2010.

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