Student, Queen's College
Wolfson Building, Parks Road, Oxford OX1 3QD
Mathematical modelling -- Cancer -- Chaste
Colorectal cancer (CRC) is thought to originate via genetic alterations that cause disruption to the dynamics of the crypts of Lieberkuhn, test-tube shaped glands that line the small and large intestine. It is believed that during carcinogenesis,cells accumulate genetic mutations that destabilise cell-cell contacts and disturb division and migration. The resulting abnormal behaviour can increase stress on the walls of the crypt, causing buckling. Such dysplastic crypts can allow the formation of a benign adenoma if mutated cells do not leave the crypt as they should, but rather persist and proliferate in a localised area. Over time and via accumulated mutations, such a growth can progress to a malignant lesion that can break through to the underlying tissue stroma, and so aid metastasis. To provide insight into the tissue-level effects of the initial genetic mutations, a multi-scale model of the crypt with a realistic, deformable geometry is required. My research concerns the development of such a model, and its usefulness as a predictive tool to further the understanding of interactions across spatial scales in the context of CRC.
A two−dimensional model of the colonic crypt accounting for the role of the basement membrane and pericryptal fibroblast sheath
J.M. Osborne S.−J. Dunn P.L. Appleton S.A. Nelson I.S. Näthke D.J. Gavaghan
In Plos Computational Biology. No. 5. Pages e1002515. 2012.
Modelling the role of the basement membrane in the colonic epithelium
J.M. Osborne S.−J. Dunn A.G. Fletcher S.J. Chapman D.J. Gavaghan
In J. Theor. Biol.. No. 298. Pages 82−91. 2012.
PROCEEDINGS OF THE OXFORD UNIVERSITY COMPUTING LABORATORY STUDENT CONFERENCE 2010
Programme Committee: Sara−Jane Dunn‚ Joe Loughry‚ Ivan Lubenko (chair) and Huy Vu
No. RR−10−22. OUCL. November, 2010.