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Biological Simulation – from simple cells to multiscale frameworks

Dr Dawn Walker ( University Lecturer, Department of Biomedical Engineering, University of Sheffield )

As the fundamental unit of life, the biological cell is a natural focus for computational simulations of growing cell population and tissues. However, models developed at the cellular scale can also be integrated into more complex multiscale models in order to examine complex biological and physical process that scan scales from the molecule to the organ.

This seminar will present a selection of the cellular scale agent-based modelling that has taken place at the University of Sheffield (where one software agent represents one biological cell) and how such models can be used to examine collective behaviour in cellular systems. Finally some of the issues in extending to multiscale models and the theoretical and computational methodologies being developed in Sheffield and by the wider community in this area will be presented.



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