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Dynamics of molecular networks and developmental landscapes during stem cell differentiation

Professor Michael Stumpf ( Chair in Theoretical Systems Biology, Imperial College London )

Gene regulation networks coordinate and control cellular behaviour throughout life. Over the course of development of multicellular organisms these networks change profoundly and in a highly controlled manner. Here I will discuss information theoretical approaches that allow us to infer aspects of these networks and how they change over development. I will discuss the improved insights that result from the application of suitable multivariate information measures.

I will then discuss the dynamical processes underlying the changes in gene regulation networks, and link these to a popular graphical representation of developmental and stem cell differentiation processes, the Waddington landscape model.




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