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Positional information theory

Professor Karen Page ( Department of Mathematics, University College London )

We study the positional information conferred by the morphogens Sonic Hedgehog and BMP in neural tube patterning. We use the mathematics of information theory to quantify the information that cells use to decide their fate. We study the encoding, recoding and decoding that take place as the morphogen gradient is formed, triggers a nuclear response and determines cell fates using a gene regulatory network.



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