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Inference Models in DNA Computing

Inaki Sainz de Murieta Fuentes ( Imperial College London )

Biomolecular Computation is a discipline that deals with the design and implementation of processing devices using a biological substrate. Due to the stability of the DNA molecule and the ease to predict the interactions between DNA strands, it has become one of the most widely used substrates, to the extend that the discipline is often related as DNA Computing. After the early models that mainly focused on the resolution of NP-complete problems, it was understood that biomolecular computers could not compete in speed and accuracy with silicon based computers. Therefore the objectives of the discipline changed, moving away from the resolution of classical computing problems towards problems where biomolecular computers show their strength with in vitro and in vivo biomedical applications. The talk will present different models of DNA devices able to implement various types of inference (logical or probabilistic) exploiting different biomolecular computation techniques (DNA strand displacement and enzymatic reactions) with potential applications in genetic diagnosis.

Speaker bio

Iñaki Sainz de Murieta is Research Associate in the Department of Bioengineering, Imperial College London.

After completion of his Computer Engineering degree from the University of Zaragoza, in 2000 he joins Procter & Gamble as information systems consultant. During this time he takes part on several international implementations of ERP and CRM systems. In 2003 he joins Hewlett Packard, where he continues working in application development focusing on project and program management.

In 2008 he decides to turn his career towards R&D, so he leaves Hewlett Packard to focus on his Artificial Intelligence PhD studies at Universidad Politécnica de Madrid. While developing his Thesis on inference models in DNA computing, under the supervision of Dr. Alfonso Rodríguez-Patón, he approached disciplines in the interplay between computer science, biology and nanotechnology. During this time he also completed the Master on Systems & Synthetic Biology at the ISSB in Paris.

After completion of his PhD in 2013 he joins the Bioengineering Department of Imperial College London as Research Associate, under the supervision of Prof. Richard Kitney.



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