Multi-scale modelling to predict strain in the femoral neck during level walking

Femoral neck response to physiological loading during level walking can be better understood, if personalized muscle and bone anatomy is considered. Finite element (FE) models of in vivo cadaveric bones combined with gait data from body-matched volunteers were used in the earlier studies, which could introduce errors in the results. The aim of the current study is to report the first fully personalized multiscale model to investigate the strains predicted at the femoral neck during a full gait cycle. CT-based Finite element models (CT/FE) of the right femur were developed following a validated framework. Muscle forces estimated by the musculoskeletal model were applied to the CT/FE model. For most of the cases, two overall peaks were predicted around 15% and 50% of the gait. Maximum strains were predicted at the superior neck region in the model. Anatomical muscle variations seem to affect femur response leading to considerable variations among individuals, both in term of the strains level and the trend at the femoral neck.