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Digging genomes and structuromes: towards “ab initio” computational biology

Professor Aleksandr Sahakyan ( Weatherall Institute of Molecular Medicine, University of Oxford )

In this talk, I shall present the past research track passing through quantum mechanical studies of small molecules to biomolecules, to proteome-wide big data analyses and computational genomics. Next, the ongoing research in our group will be presented that builds upon the expertise on different levels of information processing in life (genome, transcriptome, proteins, small molecules), to develop self-consistent “first principles” models in biology with a wide spectrum of usage. The immediate benefits and the targeted processes will be described covering different layers of the central dogma of biology, multigenic diseases and disease driver/passenger mutation predictions.

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