I use an integrative approach to cardiac electrophysiology research, combining clinical and experimental data, modelling and simulation, to investigate cardiac arrhythmias and possible therapeutic targets.
Due to the multiscale nature of cardiac electrophysiology, computational models represent the perfect framework to augment and fully analyse experimental and clinical findings. They allow for the integration of existing and new knowledge, enabling investigations of cellular processes and cardiac arrhythmias with high spatio-temporal resolution. Such an approach involves a deep understanding of multiple data sources, from cellular ionic mechanisms and signaling pathways to electrical conduction at the tissue and whole organ levels. In order to further advance our current understanding of heart function, our methodology is based on a synergistic clinical, experimental and computational approach, aiming to develop novel hypotheses, therapeutic targets, and technologies to improve risk identification under different disease conditions. Translation of results from basic science to clinical and industrial applications is central to my work via collaboration with clinicians and industrial partners.
Research areas and Collaborators:
I'm a member of the Computational Cardiovascular Science team, which is part of the Oxford BHF Centre of Research Excellence. For further details on our research and collaborators, please visit our team's website.
- Impact Acceleration Award (EPSRC, UK, 2013-2014).
- Torres Quevedo Award (Ministry of Science and Innovation, Spain, 2008).
- Computational Science and Engineering Student Prize (BGCE, Germany, 2007).
- SIAM Student Prize (Society for Industrial and Applied Mathematics, USA, 2004).
- Oliver Britton (expected October 2014).
- Xin Zhou (expected October 2015).
- Louie Cardone-Noott (expected October 2015).
- Anna Muszkiewicz (expected October 2016).
- Oliver Britton, NC3Rs Prize (Reduction, Refinement and Replacement of Animal Experimentation), 2015.
- Anna Muszkiewicz, Young Investigation Award Honorable Mention, Computing in Cardiology, 2014.
- Oliver Britton, Finalist, UK ICT Pioneers Awards, 2014.
- Oliver Britton, EPSRC PhD Prize, 2014.
- Xin Zhou, Microsoft Research Project Award, Systems Biology Doctoral Training Centre, Oxford, 2012.
- Oliver Britton, Best Project Award, Systems Biology Doctoral Training Centre, Oxford, 2011.
I obtained a MSc in Industrial Engineering (2002) and a PhD in Physics and Mathematics (2007) from the University of Castilla-La Mancha, Spain. After completion of my studies I spent two years working in industry, in the development of telecommunication networks and as Research & Development Manager. This was followed by a Postdoctoral position at the Department of Mathematics and Computer Science of the Technical University of Madrid, under a research initiative funded by AIRBUS for advanced aeronautical design. In September 2010, I joined the Computational Biology Group (Department of Computer Science, Oxford), as a Research Assistant in Computational Cardiac Electrophysiology with Prof. Blanca Rodriguez, funded by the EU preDiCT project and later by Prof. Rodriguez’ MRC award. In February 2012 I joined the Oxford Collaborative Centre for Applied Mathematics, developing innovative frameworks to describe electrical propagation in cardiac tissue. Now I'm back to the Department of Computer Science, where I continue collaborating with Prof. Rodriguez funded by her Wellcome Trust Senior Research Fellowship in Biomedical Sciences.
Inter−subject variability in human atrial action potential in sinus rhythm versus atrial fibrillation patients
C. Sánchez‚ A. Bueno−Orovio‚ E. Wettwer‚ S. Loose‚ J. Simon‚ U. Ravens‚ E. Pueyo and B.Rodriguez
In PLoS ONE. Vol. 9. No. 8. Pages e105897. 2014.
Fractional diffusion models of cardiac electrical propagation: role of structural heterogeneity in dispersion of repolarization
A. Bueno−Orovio‚ D. Kay‚ V. Grau‚ B. Rodriguez and K. Burrage
In J R Soc Interface. Vol. 11. No. 97. Pages 20140352. 2014.
Slow Adaptation of Ventricular Repolarization as a Cause of Arrhythmia?
A. Bueno−Orovio‚ B.M. Hanson‚ J.S. Gill‚ P. Taggart and B. Rodriguez
In Methods of Information in Medicine. Vol. 53. No. 4. Pages 320−323. 2014.