Gary Mirams : Publications
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[1] |
Application of cardiac electrophysiology simulations to pro−arrhythmic safety testing Gary R. Mirams‚ Mark R. Davies‚ Yi Cui‚ Peter Kohl and Denis Noble In British Journal of Pharmacology. 2012. |
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[2] |
Application of Human Stem Cell−derived Cardiomyocytes in Safety Pharmacology Requires Caution Beyond hERG M. Jonsson‚ M.A. Vos‚ G.R. Mirams‚ G. Duker‚ P. Sartipy‚ T.P. de Boer and T.A.B van Veen In Journal of Molecular and Cellular Cardiology. Vol. 52. No. 5. Pages 998−1008. 2012. |
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[3] |
Distinguishing possible mechanisms for auxin−mediated developmental control in Arabidopsis: Models with two Aux/IAA and ARF proteins‚ and two target gene−sets L. J. Bridge‚ G. R. Mirams‚ M. L. Kieffer‚ J. R. King and S. Kepinski In Mathematical Biosciences. Vol. 235. No. 1. Pages 32−44. 2012. |
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[4] |
Stochasticity in Action Potential duration Enhances Dispersion of Repolarisation at Fast Pacing Rates John Walmsley‚ Kevin Burrage‚ Joe M. Pitt−Francis‚ Gary R. Mirams and Blanca Rodriguez Vol. 102. No. 3. Pages 592a−593a. 2012. |
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[5] |
Is it time for in silico simulation of drug cardiac side effects? G.R. Mirams and D. Noble In Annals of the New York Academy of Sciences. Vol. 1245. Pages 44−47. 2011. |
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[6] |
A Local Sensitivity Analysis Method for Developing Biological Models with Identifiable Parameters: Application to Cardiac Ionic Channel Modelling (in press) A. Sher‚ K. Wang‚ A. Wathen‚ P.J. Maybank‚ G.R. Mirams‚ D. Abramson‚ D. Noble and D.J. Gavaghan In Future Generation Computer Systems. 2011. |
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[7] |
Minimum information about a cardiac electrophysiology experiment (MICEE): Standardised reporting for model reproducibility‚ interoperability‚ and data sharing T.A. Quinn‚ S. Granite‚ M.A. Allessie‚ C. Antzelevitch‚ C. Bollensdorff‚ G. Bub‚ R.A.B. Burton‚ E. Cerbaig‚ P.S. Chen‚ M. Delmar‚ D. DiFrancesco‚ Y.E. Earm‚ I.R. Efimov‚ M. Egger‚ E. Entcheva‚ M. Fink‚ R. Fischmeister‚ M.R. Franz‚ A. Garny‚ W.R. Giles‚ T. Hannes‚ S.E. Harding‚ P.J. Hunter‚ G. Iribe‚ J. Jalife‚ C.R. Johnson‚ R.S. Kass‚ I. Kodama‚ G. Koren‚ P. Lord‚ V.S. Markhasin‚ S. Matsuoka‚ A.D. McCulloch‚ G.R. Mirams‚ G.E. Morley‚ S. Nattel‚ D. Noble‚ S.P. Olesen‚ A.V. Panfilov‚ N.A. Trayanova‚ U. Ravens‚ S. Richard‚ D.S. Rosenbaum‚ Y. Rudy‚ F. Sachs‚ F.B. Sachse‚ D.A. Saint‚ U. Schotten‚ O. Solovyova‚ P. Taggart‚ L. Tung‚ A. Varró‚ P.G. Volders‚ K. Wang‚ J.N. Weiss‚ E. Wettwer‚ E. White‚ R. Wilders‚ R.L. Winslow and P. Kohl In Progress in Biophysics and Molecular Biology. Vol. 107. Pages 4 − 10. 2011. |
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[8] |
High−throughput functional curation of cellular electrophysiology models Niederer S.A. Cooper J. Mirams G.R. In Progress in Biophysics and Molecular Biology. Vol. 107. Pages 11 − 20. 2011. |
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[9] |
The significant effect of the choice of ionic current integration method in cardiac electrophysiological simulations P. Pathmanathan G.R. Mirams J.A. Southern and J.P. Whiteley In International Journal for Numerical Methods in Biomedical Engineering. Vol. 27. Pages 1751–1770. 2011. |
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[10] |
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk G. R. Mirams‚ Y. Cui‚ A. Sher‚ M. Fink‚ J. Cooper‚ B. M. Heath‚ N. C. McMahon‚ D. J. Gavaghan and D. Noble In Cardiovascular Research. Vol. 91. No. 1. Pages 53–61. 2011. |
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[11] |
Novel approaches to assessing cardiac safety−proceedings of a workshop: regulators‚ industry and academia discuss the future of in silico cardiac modelling to predict the proarrhythmic safety of drugs. K. Fletcher‚ R.R. Shah‚ A. Thomas‚ F. Tobin‚ B. Rodriguez‚ G.R. Mirams‚ J. Saiz and D. Noble In Drug safety: an international journal of medical toxicology and drug experience. Vol. 34. No. 5. Pages 439. 2011. |
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[12] |
A hybrid approach to multi−scale modelling of cancer J. M. Osborne‚ A. Walter‚ S. K. Kershaw‚ G. R. Mirams‚ A. G. Fletcher‚ P. Pathmanathan‚ D. Gavaghan‚ O. E. Jensen‚ P. K. Maini and H. M. Byrne In Philosophical Transactions of the Royal Society A: Mathematical‚ Physical and Engineering Sciences. Vol. 368. No. 1930. Pages 5013–5028. November, 2010. |
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[13] |
A Local Sensitivity Analysis Method for Developing Biological Models with Identifiable Parameters: Application to L−type Calcium Channel Modelling A. Sher‚ K. Wang‚ A. Wathen‚ G. Mirams‚ D. Abramson and D. Gavaghan In 2010 IEEE Sixth International Conference on e ??: Science. Pages 176–181. 2010. |
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[14] |
Modelling Spatially Regulated beta−Catenin Dynamics and Invasion in Intestinal Crypts Philip J. Murray‚ JW Kang‚ Gary R. Mirams‚ SY Shin‚ Helen M. Byrne‚ Philip K. Maini and KH Cho In Biophysical Journal. Vol. 99. No. 3. Pages 716–725. 2010. |
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[15] |
Phenomenological modeling of cell−to−cell and beat−to−beat variability in isolated Guinea Pig ventricular myocytes J. Walmsley‚ G. Mirams‚ M. Bahoshy‚ C. Bollensdorff‚ B. Rodriguez and K. Burrage In Engineering in Medicine and Biology Society (EMBC)‚ 2010 Annual International Conference of the IEEE. Pages 1457–1460. IEEE. , 2010. |
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[16] |
A multiple timescale analysis of a mathematical model of the Wnt/β−catenin signalling pathway G. R. Mirams‚ H. M. Byrne and J. R. King In Journal of mathematical biology. Vol. 60. No. 1. Pages 131–160. September, 2009. |
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[17] |
An integrative computational model for intestinal tissue renewal HM Byrne IMM van Leeuwen GR Mirams A Walter A Fletcher P Murray J Osborne S Varma SJ Young J Cooper B Doyle J Pitt−Francis L Momtahan P Pathmanathan JP Whiteley SJ Chapman DJ Gavaghan OE Jensen JR King PK Maini SL Waters In Cell Proliferation. Vol. 42. Pages 617−636. 2009. |
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[18] |
L−TYPE CALCIUM CHANNELS AND CALCIUM REGULATION IN VENTRICULAR MYOCYTES: IN SILICO STUDIES A. Sher‚ G. Mirams‚ DJ Gavaghan‚ D. Noble and M. Fink In JOURNAL OF PHYSIOLOGICAL SCIENCES . Vol. 59. Pages 259–259. 2009. |
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[19] |
A computational study of discrete mechanical tissue models P Pathmanathan‚ J Cooper‚ A Fletcher‚ G Mirams‚ P Murray‚ J Osborne‚ J Pitt−Francis‚ A Walter and S J Chapman In Physical Biology. Vol. 6. No. 3. 2009. |
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[20] |
Chaste: A test−driven approach to software development for biological modelling J. Pitt−Francis‚ P. Pathmanathan‚ M.O. Bernabeu‚ R. Bordas‚ J. Cooper‚ A.G. Fletcher‚ G.R. Mirams‚ P. Murray‚ J.M. Osborne‚ A. Walter‚ S.J. Chapman‚ A. Garny‚ I.M.M. van Leeuwen‚ P.K. Maini‚ B. Rodriguez‚ S.L. Waters‚ J.P. Whiteley‚ H.M. Byrne and D.J. Gavaghan In Computer Physics Communications. Vol. 180. No. 12. Pages 2452−2471. 2009. |
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[21] |
Subcellular phenomena in colorectal cancer Gary R. Mirams PhD Thesis University of Nottingham. 2008. |