InterestsCardiac electro-mechanics Coronary Blood Flow
BiographyMy research program is characterised by the development of integrated multi-scale and multi-physics models primarily of the heart which provide the ability to link biophysically detailed experimental and clinical data to integrated function from sub-cellular to whole organ level. Within the scope of this work I am interested in developed computational techniques to enable model development and specific models to provide insight into cardiac physiology. This work is focused on cardiac electrophysiology and contraction at the cellular level and the multi-scale translation of these models to simulate blood flow and cardiac electro-mechanics at the tissue level. The application of these models to understand the mechanisms of underlying coronary artery disease and heart failure to assist the development of new treatments and guide existing therapies is the ultimate goal of this work.
Theoretical Modeling in Hemodynamics of Microcirculation
Lee J. and Smith N.P.
In Microcirculation. Vol. 15(8). Pages 730−745. 2008.
The role of theoretical modeling in microcirculation research
Secomb T.W.‚ Beard D.A‚ Frisbee J.C.‚ Smith N.P. and Pries A.R.
In Microcirculation. Vol. 15(8). Pages 693−698. 2008.
Three−dimensional visualisation of cutaneous head and neck melanoma lymphoscintigraphy data
Reynolds H.M.‚ Smith N.P.‚ Uren R.‚ Thompson J.F. and Dunbar R.
In Head and Neck. 2008.
- Modelling the Cellular Cardiac-Neural Axis in the control of Myocardial Excitability
- Dissecting heart failure mechanisms
- Computer to Clinic: Personalised Fluid-Mechanical Models Applied to Heart Failure