Professor Peter Kohl MD, PhD, FHRS
Peter Kohl, Chair in Cardiac Biophysics and Systems Biology, is a Visiting Professor at Oxford Computing Science.
Peter studied Medicine and Biophysics at the Moscow Pirogov Institute (1981-1987) and, after post-graduate training and research at the Berlin Charité (PhD 1990, Facharzt 1991), he joined the Cardiac Electrophysiology Chair of Professor Denis Noble at Oxford (1992). In 1998, Peter set up the Oxford Cardiac Mechano-Electric Feedback lab, initially as a Royal Society Research Fellow, and subsequently as a Senior Fellow of the British Heart Foundation. While at Oxford, he held a Research Fellowship at Keble College (2002-2004) and was the Tutorial Fellow in Biomedical Sciences at Balliol (2004-2010). Since 2010, he is also an Affiliated Senior Fellow of the Oxford Computing Laboratory.
Peter’s team enjoys a strong international reputation in cardiac mechano-electrical interaction studies, in particular as a result of their ability to cross traditional boundaries between fields (engineering, biophysics, biology, computing) and levels (ion channel to whole organ) of investigation. Building on a solid track-record in the development and application of novel techniques, they combine experiment and computation to integrate cardiac structure-function data to address clinically-relevant research targets. The group maintains close links with leading experimental and modelling teams in the UK and elsewhere, including Auckland, Baltimore, Boulder, Ekaterinburg, Heidelberg and Okayama.
Peter directs a significant portfolio of externally-funded research, and has been a driver of international collaboration actions, such as the Network of Excellence for the EU Virtual Physiological Human Initiative whose founding director he was. He serves on editorial boards and as a reviewer for international journals and funding bodies. Peter is the coordinating editor of the primary textbook on Cardiac Mechano-Electric Coupling and Arrhythmias, and chairman of the leading international workshop series on the same topic.
Kohl P, Hunter PJ & Winslow RL. Model interactions: 'It is the simple, which is so difficult'. Progress in Biophysics and Molecular Biology 2011/107:1-3. (PBMB)
Lee P, Bollensdorff C, Quinn TA, Wuskell JP, Loew LM & Kohl P. Single-sensor system for spatially-resolved, continuous, simultaneous and multi-parametric optical mapping of cardiac tissue. Heart Rhythm 2011/8:1482-1491. (ScienceDirect)
Bub G, Tecza M, Helmes M, Lee P & Kohl P. Pixel Multiplexing for high-speed multi-resolution fluorescence imaging. Nature Methods 2010/7:209-211. (DOI)
Bub G, Camelliti P, Bollensdorff C, Stuckey D, Picton G, Burton RAB, Clarke K & Kohl P. Measurement and analysis of sarcomere length in rat cardiomycoytes in situ and in vitro. Am J Physiol 2010/298:H1616-H1625. (AJP)
Bishop MJ, Plank G, Burton RA, Schneider JE, Gavaghan DJ, Grau V & Kohl P. Development of an anatomically-detailed MRI-derived rabbit ventricular model and assessment of its impact on simulation of electrophysiological function. Am J Physiol 2010/298:H699-H718. (AJP)
Kohl P & Noble D. Systems Biology and the Virtual Physiological Human. Nature Mol Sys Biol 2009/292:1-6. (full text)
Iribe G, Ward CW, Camelliti P, Bollensdorff C, Mason F, Burton RAB, Garny A, Morphew M, Hoenger A, Lederer WJ & Kohl P. Axial stretch of rat single ventricular cardiomyocytes causes an acute and transient increase in Ca2+ spark rate. Circ Res 2009/104:787-795. (DOI)
Pellis T, Kette F, Lovisa D, Franceschino E, Maganin L, Mercante WP & Kohl P. Utility of precordial thump for treatment of out-of-hospital cardiac arrest: A prospective study. Resuscitation 2009/80:17-23. (DOI)
Garny A, Noble D, Hunter PJ & Kohl P. Cellular open resource (COR): current status and future directions. Philosophical Transactions of the Royal Society A 2009/367(1895):1885-1905. (DOI)
Cardiac Tissue Slices: Preparation‚ Handling‚ and Successful Optical Mapping
K Wang‚ P Lee‚ GR Mirams‚ P Sarathchandra‚ T Borg‚ DJ Gavaghan‚ P Kohl and C Bollensdorff
In American Journal of Physiology: Heart and Circulatory Physiology. Vol. 308. Pages H1112−H1125. 2015.
Application of cardiac electrophysiology simulations to pro−arrhythmic safety testing
Gary R. Mirams‚ Mark R. Davies‚ Yi Cui‚ Peter Kohl and Denis Noble
In British Journal of Pharmacology. Vol. 167. No. 5. Pages 932−945. 2012.
Single−sensor system for spatially resolved‚ continuous‚ and multiparametric optical mapping of cardiac tissue
P. Lee‚ C. Bollensdorff‚ T.A. Quinn‚ J.P. Wuskell‚ L.M. Loew and P. Kohl
In Heart Rhythm. Vol. 8. Pages 1482−91. 2011.