Xin Zhou : Publications
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@article{bertrand_sex-specific_2025,
title = "Sex-specific cardiometabolic multimorbidity, metabolic syndrome and left ventricular function in heart failure with preserved ejection fraction in the {UK} {Biobank}",
author = "Bertrand, Ambre and Zhou, Xin and Lewis, Andrew and Monfeuga, Thomas and Gupta, Ramneek and Grau, Vicente and Rodriguez, Blanca",
year = "2025",
issn = "1475-2840",
journal = "Cardiovascular Diabetology",
keywords = "Aged, Aged, 80 and over, Biological Specimen Banks, cardiac magnetic resonance imaging, cardiometabolic diseases, Cardiometabolic Risk Factors, Cross-Sectional Studies, Female, Health Status Disparities, Heart Failure, HFpEF, Humans, machine learning, phenomapping, Male, metabolic syndrome, Metabolic Syndrome, Middle Aged, Multimorbi",
language = "eng",
month = "jun",
number = "1",
volume = "24",
doi = "10.1186/s12933-025-02788-4",
}
@article{martinez-navarro_mechanisms_2025,
title = "Mechanisms and {Implications} of {Electrical} {Heterogeneity} in {Cardiac} {Function} in {Ischemic} {Heart} {Disease}",
author = "Martinez-Navarro, Hector and Zhou, Xin and Rodriguez, Blanca",
year = "2025",
issn = "0066-4278, 1545-1585",
journal = "Annual Review of Physiology",
language = "en",
month = "feb",
note = "Publisher: Annual Reviews",
number = "Volume 87, 2025",
pages = "25--51",
url = "https://www.annualreviews.org/content/journals/10.1146/annurev-physiol-042022-020541",
volume = "87",
doi = "10.1146/annurev-physiol-042022-020541",
}
@article{riebel_silico_2024,
title = "In silico evaluation of cell therapy in acute versus chronic infarction: role of automaticity, heterogeneity and {Purkinje} in human",
author = "Riebel, Leto Luana and Wang, Zhinuo Jenny and Martinez-Navarro, Hector and Trovato, Cristian and Camps, Julia and Berg, Lucas Arantes and Zhou, Xin and Doste, Ruben and Sachetto Oliveira, Rafael and Weber dos Santos, Rodrigo and Biasetti, Jacopo and Rodriguez, Blanca",
year = "2024",
copyright = "2024 The Author(s)",
issn = "2045-2322",
journal = "Scientific Reports",
keywords = "Arrhythmias, Computational models, Cardiac regeneration",
language = "en",
month = "sep",
note = "Publisher: Nature Publishing Group",
number = "1",
pages = "21584",
url = "https://www.nature.com/articles/s41598-024-67951-5",
volume = "14",
doi = "10.1038/s41598-024-67951-5",
}
@article{zhou_lower_2024,
title = "Lower diastolic tension may be indicative of higher proarrhythmic propensity in failing human cardiomyocytes",
author = "Zhou, Xin and Levesque, Paul and Chaudhary, Khuram and Davis, Myrtle and Rodriguez, Blanca",
year = "2024",
copyright = "2024 The Author(s)",
issn = "2045-2322",
journal = "Scientific Reports",
keywords = "Ventricular tachycardia, Computational models",
language = "en",
month = "jul",
note = "Publisher: Nature Publishing Group",
number = "1",
pages = "17351",
url = "https://www.nature.com/articles/s41598-024-65249-0",
volume = "14",
doi = "10.1038/s41598-024-65249-0",
}
@article{camps_digital_2024,
title = "Digital twinning of the human ventricular activation sequence to {Clinical} 12-lead {ECGs} and magnetic resonance imaging using realistic {Purkinje} networks for in silico clinical trials",
author = "Camps, Julia and Berg, Lucas Arantes and Wang, Zhinuo Jenny and Sebastian, Rafael and Riebel, Leto Luana and Doste, Ruben and Zhou, Xin and Sachetto, Rafael and Coleman, James and Lawson, Brodie and Grau, Vicente and Burrage, Kevin and Bueno-Orovio, Alfonso and Weber Dos Santos, Rodrigo and Rodriguez, Blanca",
year = "2024",
issn = "1361-8423",
journal = "Medical Image Analysis",
keywords = "Humans, Myocardium, Computer Simulation, Electrocardiography, Purkinje Fibers, Magnetic Resonance Imaging, Cardiac magnetic resonance, Bayesian inference, Cardiac digital twin, Purkinje network",
language = "eng",
month = "may",
pages = "103108",
volume = "94",
doi = "10.1016/j.media.2024.103108",
}
@article{zhou_clinical_2024,
title = "Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations",
author = "Zhou, Xin and Wang, Zhinuo Jenny and Camps, Julia and Tomek, Jakub and Santiago, Alfonso and Quintanas, Adria and Vazquez, Mariano and Vaseghi, Marmar and Rodriguez, Blanca",
year = "2024",
editor = "Chiamvimonvat, Nipavan and Barton, Matthias",
issn = "2050-084X",
journal = "eLife",
keywords = "electrocardiogram, modelling and simulation, cardiac electromechanics, disease mechanisms, multiscale, post-myocardial infarction",
month = "dec",
note = "Publisher: eLife Sciences Publications, Ltd",
pages = "RP93002",
url = "https://doi.org/10.7554/eLife.93002",
volume = "13",
doi = "10.7554/eLife.93002",
}
@article{szlovak_blockade_2021,
title = "Blockade of sodium‑calcium exchanger via {ORM}-10962 attenuates cardiac alternans",
author = "Szlovák, Jozefina and Tomek, Jakub and Zhou, Xin and Tóth, Noémi and Veress, Roland and Horváth, Balázs and Szentandrássy, Norbert and Levijoki, Jouko and Papp, Julius Gy and Herring, Neil and Varró, András and Eisner, David A. and Rodriguez, Blanca and Nagy, Norbert",
year = "2021",
issn = "0022-2828, 1095-8584",
journal = "Journal of Molecular and Cellular Cardiology",
language = "English",
month = "apr",
note = "Publisher: Elsevier",
pages = "111--122",
url = "https://www.jmmc-online.com/article/S0022-2828(20)30355-2/abstract",
volume = "153",
doi = "10.1016/j.yjmcc.2020.12.015",
}
@article{wang_human_2021,
title = "Human biventricular electromechanical simulations on the progression of electrocardiographic and mechanical abnormalities in post-myocardial infarction",
author = "Wang, Zhinuo J. and Santiago, Alfonso and Zhou, Xin and Wang, Lei and Margara, Francesca and Levrero-Florencio, Francesc and Das, Arka and Kelly, Chris and Dall'Armellina, Erica and Vazquez, Mariano and Rodriguez, Blanca",
year = "2021",
issn = "1532-2092",
journal = "Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology",
keywords = "Myocardial infarction, Electrocardiogram, Ejection fraction, Computer modelling, Electromechanical simulations",
language = "eng",
month = "mar",
number = "Supplement\_1",
pages = "i143--i152",
volume = "23",
doi = "10.1093/europace/euaa405",
}
@article{13818,
title = "Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment.",
author = "Xin Zhou and Yusheng Qu and Elisa Passini and Alfonso Bueno-Orovio and Yang Liu and Hugo Vargas and Blanca Rodriguez.",
year = "2020",
journal = "Frontiers in Pharmacology",
month = "January",
pages = "10:1643",
doi = "10.3389/fphar.2019.01643",
}
@article{13816,
title = "General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico.",
author = "Zhihua Li, Gary R. Mirams, Takashi Yoshinaga, Bradley J Ridder, Xiaomei Han, Janell E. Chen, Norman L. Stockbridge, Todd A. Wisialowski, Bruce Damiano, Stefano Severi, Pierre Morissette, Peter R. Kowey, Mark Holbrook, Godfrey Smith, Randall L. Rasmusson, Michael Liu, Zhen Song, Zhilin Qu, Derek J. Leishman, Jill Steidl-Nichols, Blanca Rodriguez, Alfonso Bueno-Orovio, Xin Zhou, Elisa Passini, Andrew G. Edwards, Stefano Morotti, Haibo Ni, Eleonora Grandi, Colleen E. Clancy, Jamie Vandenberg, Adam Hill, Mikiko Nakamura, Thomas Singer, Liudmila Polonchuk, Andrea Greiter-Wilke, Ken Wang, Stephane Nave, Aaron Fullerton, Eric A. Sobie, Michelangelo Paci, Flora Musuamba Tshinanu, David G. Strauss.",
year = "2020",
journal = "Clinical Pharmacology and Therapeutics",
month = "January",
pages = "107(1):102-111",
doi = "10.1002/cpt.1647",
}
@article{https://doi.org/10.1098/rsfs.2019.0124,
title = "Electrophysiological and anatomical factors determine arrhythmic risk in acute myocardial ischaemia and its modulation by sodium current availability.",
author = "Hector Martinez-Navarro and Xin Zhou and Alfonso Bueno-Orovio and Blanca Rodriguez",
year = "2020",
journal = "The Royal Society Interface Focus",
}
@article{https://doi.org/10.1016/j.jocs.2020.101202,
title = "The virtual assay software for human in silico drug trials to augment drug cardiac testing.",
author = "Elisa Passini, Xin Zhou, Cristian Trovato, Oliver J Britton, Alfonso Bueno-Orovio, Blanca Rodriguez",
year = "2020",
journal = "Journal of Computational Science",
}
@article{13815,
title = "A modeling and machine learning approach to ECG feature engineering for the detection of ischemia using pseudo-ECG.",
author = "Carlos A. Ledezma, Xin Zhou, Blanca Rodríguez, P. J. Tan, Vanessa Díaz-Zuccarini.",
year = "2019",
journal = "Plos One",
month = "August",
pages = "12;14(8): e0220294",
doi = "10.1371/journal.pone.0220294",
}
@article{13814,
title = "Investigating the complex arrhythmic phenotype caused by a potassium channel gain-of-function mutation.",
author = "Xin Zhou, Alfonso Bueno-Orovio, Richard J. Schilling, Claire Kirkby, Chris Denning, Divya Rajamohan, Kevin Burrage, Andrew Tinker, Blanca Rodriguez and Stephen C. Harmer.",
year = "2019",
journal = "Frontiers in Physiology",
month = "March",
pages = "10: 259",
doi = "10.3389/fphys.2019.00259",
}
@article{13817,
title = "Development, calibration, and validation of a novel human ventricular myocyte model in health, disease and drug block.",
author = "Jakub Tomek and Alfonso Bueno-Orovio and Elisa Passini and Xin Zhou and Ana Minchole and Oliver Britton and Chiara Bartolucci and Stefano Severi and Alvin Shrier and Laszlo Virag and Andras Varro and Blanca Rodriguez.",
year = "2019",
journal = "eLife",
month = "December",
pages = "8. pii: e48890",
doi = "10.7554/eLife.48890",
}
@article{13813,
title = "Modulation of cardiac alternans by altered sarcoplasmic reticulum calcium release: a simulation study.",
author = "Jakub Tomek and Markéta Tomková and Xin Zhou and Gil Bub and Blanca Rodriguez.",
year = "2018",
journal = "Frontiers in Physiology",
month = "September",
pages = "9:1306",
doi = "10.3389/fphys.2018.01306",
}
@article{13812,
title = "In silico evaluation of arrhythmia.",
author = "Xin Zhou and Alfonso Bueno-Orovio and Blanca Rodriguez.",
year = "2018",
journal = "Current Opinion in Physiology",
pages = "01:95–103",
doi = "10.1016/j.cophys.2017.11.003",
}
@article{10264,
title = "In Vivo and In Silico Investigation into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular Cardiomyocytes",
author = "Xin Zhou and Alfonso Bueno-Orovio and Michele Orini and Ben Hanson and Martin Hayward and Peter Taggart and Pier D. Lambiase and Kevin Burrage and Blanca Rodriguez",
year = "2016",
journal = "Circulation Research",
url = "http://circres.ahajournals.org/content/early/2015/11/24/CIRCRESAHA.115.307836.abstract",
doi = "10.1161/CIRCRESAHA.115.307836",
}
@article{10263,
title = "Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm.",
author = "Anna Muszkiewicz and Oliver J. Britton and Philip Gemmell and Elisa Passini and Carlos Sánchez and Xin Zhou and Annamaria Carusi and T. Alexander Quinn and Kevin Burrage and Alfonso Bueno-Orovio and Blanca Rodriguez",
year = "2016",
journal = "Progress in Biophysics and Molecular Biology",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26701222",
doi = "10.1016/j.pbiomolbio.2015.12.002",
}
@article{10262,
title = "Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop",
author = "Blanca Rodriguez and Annamaria Carusi and Najah Abi-Gerges and Rina Ariga and Oliver Britton and Gil Bub and Alfonso Bueno-Orovio and Rebecca A. B. Burton and Valentina Carapella and Louie Cardone-Noott and Matthew J. Daniels and Mark R. Davies and Sara Dutta and Andre Ghetti and Vicente Grau and Stephen Harmer and Ivan Kopljar and Pier Lambiase and Hua Rong Lu and Aurore Lyon and Ana Minchole and Anna Muszkiewicz and Julien Oster and Michelangelo Paci and Elisa Passini and Stefano Severi and Peter Taggart and Andy Tinker and Jean-Pierre Valentin and Andras Varro and Mikael Wallman and Xin Zhou",
year = "2016",
journal = "Europace",
url = "http://europace.oxfordjournals.org/content/early/2015/11/29/europace.euv320.long",
doi = "10.1093/europace/euv320",
}
@conference{13811,
title = "How can a gain-of-function mutation in KCNQ1 lead to action potential prolongation?",
author = "Xin Zhou and Stephen Harmer and Alfonso Bueno-Orovio and Kevin Burrage and Andrew Tinker and Blanca Rodriguez.",
year = "2016",
journal = "Heart Rhythm",
pages = "13(5) S545",
}
@conference{13810,
title = "Effects and underlying mechanisms of refractory period pacing on repolarization dynamics in the human heart.",
author = "Diogo Santos and Michele Orini and Xin Zhou and Alfonso Bueno-Orovio and Ben Hanson and Peter Taggart and Martin Hayward and Blanca Rodriguez and Pier Lambiase",
year = "2016",
journal = "Conf Proc IEEE Eng Med Biol Soc",
pages = "157-160",
}
@inproceedings{title = "HERG determines alternating behavior at fast pacing by modulating action potential morphology and sarcolemmal Ca2+ balance",
title = "HERG determines alternating behavior at fast pacing by modulating action potential morphology and sarcolemmal Ca2+ balance",
author = "Xin Zhou and Bueno-Orovio, A. and Orini, M. and Hanson, B. and Hayward, M. and Taggart, P. and Lambiase, P.D. and Burrage, K. and Rodriguez, B.",
year = "2014",
booktitle = "Heart Rhythm",
issn = "1547-5271",
month = "May",
number = "5 Supplement",
url = "http://www.heartrhythmjournal.com/article/S1547-5271(14)00309-9/abstract",
volume = "11",
}
@inproceedings{6713512,
title = "Population of human ventricular cell models calibrated with in vivo measurements unravels ionic mechanisms of cardiac alternans",
author = "Xin Zhou and Bueno-Orovio, A. and Orini, M. and Hanson, B. and Hayward, M. and Taggart, P. and Lambiase, P.D. and Burrage, K. and Rodriguez, B.",
year = "2013",
booktitle = "Computing in Cardiology Conference (CinC), 2013",
issn = "2325-8861",
keywords = "bioelectric potentials;calcium;calibration;cardiovascular system;cellular biophysics;diseases;electrocardiography;ion exchange;potassium;rectification;sodium;surgery;L-type calcium current;O'Hara-Rudy dynamic model;SR calcium reuptake flux;arrhythmia;cardiac alternans;cardiac physiology;cardiac surgery;fast sodium current;human ventricular cell model calibration population;human ventricular electrophysiology;in silico population;in vivo measurements;ionic currents;ionic mechanisms;pathological conditions;rapid delayed rectifier potassium current;sarcoplasmic reticulum calcium release flux;sodium calcium exchanger current;Abstracts;Acceleration;Analytical models;Biological system modeling;Computational modeling;Lead",
month = "Sept",
pages = "855-858",
}
@article{Vinod20131,
title = "The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles",
author = "P.K. Vinod and Xin Zhou and Tongli Zhang and Thomas U. Mayer and Bela Novak",
year = "2013",
issn = "0301-4622",
journal = "Biophysical Chemistry",
number = "0",
pages = "1 - 6",
url = "http://www.sciencedirect.com/science/article/pii/S0301462213000574",
volume = "177–178",
doi = "10.1016/j.bpc.2013.03.002",
}