Xin Zhou : Publications

Sex−specific cardiometabolic multimorbidity‚ metabolic syndrome and left ventricular function in heart failure with preserved ejection fraction in the UK Biobank

Ambre Bertrand‚ Xin Zhou‚ Andrew Lewis‚ Thomas Monfeuga‚ Ramneek Gupta‚ Vicente Grau and Blanca Rodriguez

In Cardiovascular Diabetology. Vol. 24. No. 1. June, 2025.

Details about Sex−specific cardiometabolic multimorbidity‚ metabolic syndrome and left ventricular function in heart failure with preserved ejection fraction in the UK Biobank | BibTeX data for Sex−specific cardiometabolic multimorbidity‚ metabolic syndrome and left ventricular function in heart failure with preserved ejection fraction in the UK Biobank | DOI (10.1186/s12933-025-02788-4)

Mechanisms and Implications of Electrical Heterogeneity in Cardiac Function in Ischemic Heart Disease

Hector Martinez−Navarro‚ Xin Zhou and Blanca Rodriguez

In Annual Review of Physiology. Vol. 87. No. Volume 87‚ 2025. Pages 25–51. February, 2025.

Publisher: Annual Reviews

Details about Mechanisms and Implications of Electrical Heterogeneity in Cardiac Function in Ischemic Heart Disease | BibTeX data for Mechanisms and Implications of Electrical Heterogeneity in Cardiac Function in Ischemic Heart Disease | DOI (10.1146/annurev-physiol-042022-020541) | Link to Mechanisms and Implications of Electrical Heterogeneity in Cardiac Function in Ischemic Heart Disease

Lower diastolic tension may be indicative of higher proarrhythmic propensity in failing human cardiomyocytes

Xin Zhou‚ Paul Levesque‚ Khuram Chaudhary‚ Myrtle Davis and Blanca Rodriguez

In Scientific Reports. Vol. 14. No. 1. Pages 17351. July, 2024.

Publisher: Nature Publishing Group

Details about Lower diastolic tension may be indicative of higher proarrhythmic propensity in failing human cardiomyocytes | BibTeX data for Lower diastolic tension may be indicative of higher proarrhythmic propensity in failing human cardiomyocytes | DOI (10.1038/s41598-024-65249-0) | Link to Lower diastolic tension may be indicative of higher proarrhythmic propensity in failing human cardiomyocytes

In silico evaluation of cell therapy in acute versus chronic infarction: role of automaticity‚ heterogeneity and Purkinje in human

Leto Luana Riebel‚ Zhinuo Jenny Wang‚ Hector Martinez−Navarro‚ Cristian Trovato‚ Julia Camps‚ Lucas Arantes Berg‚ Xin Zhou‚ Ruben Doste‚ Rafael Sachetto Oliveira‚ Rodrigo Weber dos Santos‚ Jacopo Biasetti and Blanca Rodriguez

In Scientific Reports. Vol. 14. No. 1. Pages 21584. September, 2024.

Publisher: Nature Publishing Group

Details about In silico evaluation of cell therapy in acute versus chronic infarction: role of automaticity‚ heterogeneity and Purkinje in human | BibTeX data for In silico evaluation of cell therapy in acute versus chronic infarction: role of automaticity‚ heterogeneity and Purkinje in human | DOI (10.1038/s41598-024-67951-5) | Link to In silico evaluation of cell therapy in acute versus chronic infarction: role of automaticity‚ heterogeneity and Purkinje in human

Digital twinning of the human ventricular activation sequence to Clinical 12−lead ECGs and magnetic resonance imaging using realistic Purkinje networks for in silico clinical trials

Julia Camps‚ Lucas Arantes Berg‚ Zhinuo Jenny Wang‚ Rafael Sebastian‚ Leto Luana Riebel‚ Ruben Doste‚ Xin Zhou‚ Rafael Sachetto‚ James Coleman‚ Brodie Lawson‚ Vicente Grau‚ Kevin Burrage‚ Alfonso Bueno−Orovio‚ Rodrigo Weber Dos Santos and Blanca Rodriguez

In Medical Image Analysis. Vol. 94. Pages 103108. May, 2024.

Details about Digital twinning of the human ventricular activation sequence to Clinical 12−lead ECGs and magnetic resonance imaging using realistic Purkinje networks for in silico clinical trials | BibTeX data for Digital twinning of the human ventricular activation sequence to Clinical 12−lead ECGs and magnetic resonance imaging using realistic Purkinje networks for in silico clinical trials | DOI (10.1016/j.media.2024.103108)

Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations

Xin Zhou‚ Zhinuo Jenny Wang‚ Julia Camps‚ Jakub Tomek‚ Alfonso Santiago‚ Adria Quintanas‚ Mariano Vazquez‚ Marmar Vaseghi and Blanca Rodriguez

In eLife. Vol. 13. Pages RP93002. December, 2024.

Publisher: eLife Sciences Publications‚ Ltd

Details about Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations | BibTeX data for Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations | DOI (10.7554/eLife.93002) | Link to Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations

Blockade of sodium‑calcium exchanger via ORM−10962 attenuates cardiac alternans

Jozefina Szlovák‚ Jakub Tomek‚ Xin Zhou‚ Noémi Tóth‚ Roland Veress‚ Balázs Horváth‚ Norbert Szentandrássy‚ Jouko Levijoki‚ Julius Gy Papp‚ Neil Herring‚ András Varró‚ David A. Eisner‚ Blanca Rodriguez and Norbert Nagy

In Journal of Molecular and Cellular Cardiology. Vol. 153. Pages 111–122. April, 2021.

Publisher: Elsevier

Details about Blockade of sodium‑calcium exchanger via ORM−10962 attenuates cardiac alternans | BibTeX data for Blockade of sodium‑calcium exchanger via ORM−10962 attenuates cardiac alternans | DOI (10.1016/j.yjmcc.2020.12.015) | Link to Blockade of sodium‑calcium exchanger via ORM−10962 attenuates cardiac alternans

Human biventricular electromechanical simulations on the progression of electrocardiographic and mechanical abnormalities in post−myocardial infarction

Zhinuo J. Wang‚ Alfonso Santiago‚ Xin Zhou‚ Lei Wang‚ Francesca Margara‚ Francesc Levrero−Florencio‚ Arka Das‚ Chris Kelly‚ Erica Dall'Armellina‚ Mariano Vazquez and Blanca Rodriguez

In Europace: European Pacing‚ Arrhythmias‚ and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing‚ Arrhythmias‚ and Cardiac Cellular Electrophysiology of the European Society of Cardiology. Vol. 23. No. Supplement_1. Pages i143–i152. March, 2021.

Details about Human biventricular electromechanical simulations on the progression of electrocardiographic and mechanical abnormalities in post−myocardial infarction | BibTeX data for Human biventricular electromechanical simulations on the progression of electrocardiographic and mechanical abnormalities in post−myocardial infarction | DOI (10.1093/europace/euaa405)

Electrophysiological and anatomical factors determine arrhythmic risk in acute myocardial ischaemia and its modulation by sodium current availability.

Hector Martinez−Navarro‚ Xin Zhou‚ Alfonso Bueno−Orovio and Blanca Rodriguez

In The Royal Society Interface Focus. 2020.

Details about Electrophysiological and anatomical factors determine arrhythmic risk in acute myocardial ischaemia and its modulation by sodium current availability. | BibTeX data for Electrophysiological and anatomical factors determine arrhythmic risk in acute myocardial ischaemia and its modulation by sodium current availability.

The virtual assay software for human in silico drug trials to augment drug cardiac testing.

Blanca Rodriguez Elisa Passini Xin Zhou Cristian Trovato Oliver J Britton Alfonso Bueno−Orovio

In Journal of Computational Science. 2020.

Details about The virtual assay software for human in silico drug trials to augment drug cardiac testing. | BibTeX data for The virtual assay software for human in silico drug trials to augment drug cardiac testing.

Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment.

Xin Zhou‚ Yusheng Qu‚ Elisa Passini‚ Alfonso Bueno−Orovio‚ Yang Liu‚ Hugo Vargas and Blanca Rodriguez.

In Frontiers in Pharmacology. Pages 10:1643. January, 2020.

Details about Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment. | BibTeX data for Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment. | DOI (10.3389/fphar.2019.01643)

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico.

David G. Strauss. Zhihua Li Gary R. Mirams Takashi Yoshinaga Bradley J Ridder Xiaomei Han Janell E. Chen Norman L. Stockbridge Todd A. Wisialowski Bruce Damiano Stefano Severi Pierre Morissette Peter R. Kowey Mark Holbrook Godfrey Smith Randall L. Rasmusson Michael Liu Zhen Song Zhilin Qu Derek J. Leishman Jill Steidl−Nichols Blanca Rodriguez Alfonso Bueno−Orovio Xin Zhou Elisa Passini Andrew G. Edwards Stefano Morotti Haibo Ni Eleonora Grandi Colleen E. Clancy Jamie Vandenberg Adam Hill Mikiko Nakamura Thomas Singer Liudmila Polonchuk Andrea Greiter−Wilke Ken Wang Stephane Nave Aaron Fullerton Eric A. Sobie Michelangelo Paci Flora Musuamba Tshinanu

In Clinical Pharmacology and Therapeutics. Pages 107(1):102−111. January, 2020.

Details about General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico. | BibTeX data for General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico. | DOI (10.1002/cpt.1647)

A modeling and machine learning approach to ECG feature engineering for the detection of ischemia using pseudo−ECG.

Vanessa Díaz−Zuccarini. Carlos A. Ledezma Xin Zhou Blanca Rodríguez P. J. Tan

In Plos One. Pages 12;14(8): e0220294. August, 2019.

Details about A modeling and machine learning approach to ECG feature engineering for the detection of ischemia using pseudo−ECG. | BibTeX data for A modeling and machine learning approach to ECG feature engineering for the detection of ischemia using pseudo−ECG. | DOI (10.1371/journal.pone.0220294)

Investigating the complex arrhythmic phenotype caused by a potassium channel gain−of−function mutation.

Blanca Rodriguez Xin Zhou Alfonso Bueno−Orovio Richard J. Schilling Claire Kirkby Chris Denning Divya Rajamohan Kevin Burrage Andrew Tinker and Stephen C. Harmer.

In Frontiers in Physiology. Pages 10: 259. March, 2019.

Details about Investigating the complex arrhythmic phenotype caused by a potassium channel gain−of−function mutation. | BibTeX data for Investigating the complex arrhythmic phenotype caused by a potassium channel gain−of−function mutation. | DOI (10.3389/fphys.2019.00259)

Development‚ calibration‚ and validation of a novel human ventricular myocyte model in health‚ disease and drug block.

Jakub Tomek‚ Alfonso Bueno−Orovio‚ Elisa Passini‚ Xin Zhou‚ Ana Minchole‚ Oliver Britton‚ Chiara Bartolucci‚ Stefano Severi‚ Alvin Shrier‚ Laszlo Virag‚ Andras Varro and Blanca Rodriguez.

In eLife. Pages 8. pii: e48890. December, 2019.

Details about Development‚ calibration‚ and validation of a novel human ventricular myocyte model in health‚ disease and drug block. | BibTeX data for Development‚ calibration‚ and validation of a novel human ventricular myocyte model in health‚ disease and drug block. | DOI (10.7554/eLife.48890)

Modulation of cardiac alternans by altered sarcoplasmic reticulum calcium release: a simulation study.

Jakub Tomek‚ Markéta Tomková‚ Xin Zhou‚ Gil Bub and Blanca Rodriguez.

In Frontiers in Physiology. Pages 9:1306. September, 2018.

Details about Modulation of cardiac alternans by altered sarcoplasmic reticulum calcium release: a simulation study. | BibTeX data for Modulation of cardiac alternans by altered sarcoplasmic reticulum calcium release: a simulation study. | DOI (10.3389/fphys.2018.01306)

In silico evaluation of arrhythmia.

Xin Zhou‚ Alfonso Bueno−Orovio and Blanca Rodriguez.

In Current Opinion in Physiology. Pages 01:95–103. 2018.

Details about In silico evaluation of arrhythmia. | BibTeX data for In silico evaluation of arrhythmia. | DOI (10.1016/j.cophys.2017.11.003)

Variability in cardiac electrophysiology: Using experimentally−calibrated populations of models to move beyond the single virtual physiological human paradigm.

Anna Muszkiewicz‚ Oliver J. Britton‚ Philip Gemmell‚ Elisa Passini‚ Carlos Sánchez‚ Xin Zhou‚ Annamaria Carusi‚ T. Alexander Quinn‚ Kevin Burrage‚ Alfonso Bueno−Orovio and Blanca Rodriguez

In Progress in Biophysics and Molecular Biology. 2016.

Details about Variability in cardiac electrophysiology: Using experimentally−calibrated populations of models to move beyond the single virtual physiological human paradigm. | BibTeX data for Variability in cardiac electrophysiology: Using experimentally−calibrated populations of models to move beyond the single virtual physiological human paradigm. | DOI (10.1016/j.pbiomolbio.2015.12.002) | Link to Variability in cardiac electrophysiology: Using experimentally−calibrated populations of models to move beyond the single virtual physiological human paradigm.

How can a gain−of−function mutation in KCNQ1 lead to action potential prolongation?

Xin Zhou‚ Stephen Harmer‚ Alfonso Bueno−Orovio‚ Kevin Burrage‚ Andrew Tinker and Blanca Rodriguez.

Pages 13(5) S545. 2016.

Details about How can a gain−of−function mutation in KCNQ1 lead to action potential prolongation? | BibTeX data for How can a gain−of−function mutation in KCNQ1 lead to action potential prolongation?

Human−based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop

Blanca Rodriguez‚ Annamaria Carusi‚ Najah Abi−Gerges‚ Rina Ariga‚ Oliver Britton‚ Gil Bub‚ Alfonso Bueno−Orovio‚ Rebecca A. B. Burton‚ Valentina Carapella‚ Louie Cardone−Noott‚ Matthew J. Daniels‚ Mark R. Davies‚ Sara Dutta‚ Andre Ghetti‚ Vicente Grau‚ Stephen Harmer‚ Ivan Kopljar‚ Pier Lambiase‚ Hua Rong Lu‚ Aurore Lyon‚ Ana Minchole‚ Anna Muszkiewicz‚ Julien Oster‚ Michelangelo Paci‚ Elisa Passini‚ Stefano Severi‚ Peter Taggart‚ Andy Tinker‚ Jean−Pierre Valentin‚ Andras Varro‚ Mikael Wallman and Xin Zhou

In Europace. 2016.

Details about Human−based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop | BibTeX data for Human−based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop | DOI (10.1093/europace/euv320) | Link to Human−based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop

Effects and underlying mechanisms of refractory period pacing on repolarization dynamics in the human heart.

Diogo Santos‚ Michele Orini‚ Xin Zhou‚ Alfonso Bueno−Orovio‚ Ben Hanson‚ Peter Taggart‚ Martin Hayward‚ Blanca Rodriguez and Pier Lambiase

Pages 157−160. 2016.

Details about Effects and underlying mechanisms of refractory period pacing on repolarization dynamics in the human heart. | BibTeX data for Effects and underlying mechanisms of refractory period pacing on repolarization dynamics in the human heart.

In Vivo and In Silico Investigation into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular Cardiomyocytes

Xin Zhou‚ Alfonso Bueno−Orovio‚ Michele Orini‚ Ben Hanson‚ Martin Hayward‚ Peter Taggart‚ Pier D. Lambiase‚ Kevin Burrage and Blanca Rodriguez

In Circulation Research. 2016.

Details about In Vivo and In Silico Investigation into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular Cardiomyocytes | BibTeX data for In Vivo and In Silico Investigation into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular Cardiomyocytes | DOI (10.1161/CIRCRESAHA.115.307836) | Link to In Vivo and In Silico Investigation into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular Cardiomyocytes

HERG determines alternating behavior at fast pacing by modulating action potential morphology and sarcolemmal Ca2+ balance

Xin Zhou‚ A. Bueno−Orovio‚ M. Orini‚ B. Hanson‚ M. Hayward‚ P. Taggart‚ P.D. Lambiase‚ K. Burrage and B. Rodriguez

In Heart Rhythm. Vol. 11. No. 5 Supplement. May, 2014.

Details about HERG determines alternating behavior at fast pacing by modulating action potential morphology and sarcolemmal Ca2+ balance | BibTeX data for HERG determines alternating behavior at fast pacing by modulating action potential morphology and sarcolemmal Ca2+ balance | Link to HERG determines alternating behavior at fast pacing by modulating action potential morphology and sarcolemmal Ca2+ balance

The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles

P.K. Vinod‚ Xin Zhou‚ Tongli Zhang‚ Thomas U. Mayer and Bela Novak

In Biophysical Chemistry. Vol. 177–178. No. 0. Pages 1 − 6. 2013.

Details about The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles | BibTeX data for The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles | DOI (10.1016/j.bpc.2013.03.002) | Link to The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles

Population of human ventricular cell models calibrated with in vivo measurements unravels ionic mechanisms of cardiac alternans

Xin Zhou‚ A. Bueno−Orovio‚ M. Orini‚ B. Hanson‚ M. Hayward‚ P. Taggart‚ P.D. Lambiase‚ K. Burrage and B. Rodriguez

In Computing in Cardiology Conference (CinC)‚ 2013. Pages 855−858. September, 2013.

Details about Population of human ventricular cell models calibrated with in vivo measurements unravels ionic mechanisms of cardiac alternans | BibTeX data for Population of human ventricular cell models calibrated with in vivo measurements unravels ionic mechanisms of cardiac alternans