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Xin Zhou

Personal photo - Xin Zhou

Xin Zhou

Oxford-BMS Fellow

E: xin.zhou<at>cs.ox.ac.uk

Wolfson Building, Parks Road, Oxford OX1 3QD

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I use an integrative approach to computational cardiovascular research, combining clinical and experimental data with multi-scale modelling and simulation to investigate cardiac disease mechanisms and support in silico drug evaluation.

My work focuses on the electromechanical function of the human heart, particularly in the context of ischemic heart disease and heart failure. Computational models provide a powerful framework to augment experimental and clinical findings, enabling mechanistic investigations with high spatio-temporal resolution. This approach involves understanding ionic currents, tissue-level conduction, and organ-level dynamics, and translating these insights into clinical and industrial applications.

I collaborate closely with clinicians and pharmaceutical partners to develop predictive models for cardiac safety and efficacy, contributing to regulatory science and drug development. My research aims to improve patient stratification and reduce reliance on animal testing through validated human-based simulations.

Funding and Awards

Oxford-Bristol Myers Squibb Fellowship, University of Oxford (Co-applicant and Fellow)

EPSRC Impact Acceleration Account Technology Fund, University of Oxford (Principal Investigator)

Model of the Year 2024, BioModels

Recognition Award for Excellence, Department of Computer Science, University of Oxford (2019)

Microsoft Research Project Award, Systems Biology DTC, Oxford (2012)


Teaching and Supervision

PhD Students:

Milda Folkmanaite, Department of Physiology, Anatomy and Genetics, University of Oxford (2024)

Beth McMillan, Department of Computer Science, University of Oxford (2022)

MSc Students:

Ioana Gherman, Department of Computer Science, University of Oxford (2017)

Francesca Margara, Department of Computer Science, University of Oxford / University of Bologna (2017–2018)

Course Marking:

Computational Medicine, Department of Computer Science, University of Oxford (2024–2025)

 

Biography

Dr Xin Zhou obtained her DPhil in Computational Biology from the University of Oxford, following MSc and BSc degrees in Life Sciences from Beijing Normal University. Her doctoral research focused on modelling and simulation of human ventricular electrophysiology, combining in vivo human data with computational approaches to investigate cardiac alternans.

She began her postdoctoral research in the Computational Cardiovascular Science group at Oxford in 2016, where her work expanded to multi-scale modelling of cardiac electromechanics and post-infarction remodelling. In 2021, she became an Oxford-Bristol Myers Squibb Fellow, developing human-based models of heart failure and collaborating with pharmaceutical companies to support in silico drug testing.

Her research has been published in Circulation Research, eLife, Scientific Reports, and Cardiovascular Diabetology, and was awarded “Model of the Year 2024” by BioModels. She serves as an editorial board member of Frontiers in Physiology since 2020.

Selected Publications

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