Pras Pathmanathan

Dr Pras Pathmanathan

Research Officer

pras@cs.ox.ac.uk

Wolfson Building, Parks Road, Oxford OX1 3QD

Interests

I am a jointly a researcher in the Computational Biology Group, a multi-disciplinary group based in the Department of Computer Science, and a research fellow at the Center for Devices and Radiological Health, Food and Drug Administration (FDA). As of May 2012 I am based at the FDA just outside of Washington DC.

I work in the modelling of biological function, generally at the cellular or organ levels. My main research interests are modelling cardiac electro-physiological activity, cardiac mechanical activity and soft-tissue mechanics in general, mostly from a numerical methods and mathematical modelling view, and with extensive use of nonlinear elasticity theory and the finite element method. I am also involved in work on discrete cellular modelling (with applications in advancing understanding of the onset of cancer) and lung modelling. I am heavily involved with the Chaste (Cancer, Heart and Soft Tissue Environment) project, in which we have developed a powerful, efficient, general and reliable tool for solving computationally-demanding problems in biological modelling. I am also an Associate Fellow in the 2020 Science Program.

Numerical Methods and Object-Oriented Design:

This 6 hour course (run summer 2011) describes numerical schemes for solving ODEs and PDEs, and discusses how to implement solvers in an object-oriented manner. General designs are described, as well as (slightly simplified) descriptions of the designs used in Chaste.

All lectures - all lectures (no transitions) - lecture 1 - lecture 2 - lecture 3 - lecture 4 - lecture 5 - lecture 6

Selected Publications

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Manage publications

The significant effect of the choice of ionic current integration method in cardiac electrophysiological simulations

P. Pathmanathan G.R. Mirams J.A. Southern and J.P. Whiteley

In International Journal for Numerical Methods in Biomedical Engineering. Vol. 27. Pages 1751–1770. 2011.

Details | BibTeX | DOI (10.1002/cnm.1438)

A hybrid approach to multi−scale modelling of cancer

J. M. Osborne‚ A. Walter‚ S. K. Kershaw‚ G. R. Mirams‚ A. G. Fletcher‚ P. Pathmanathan‚ D. Gavaghan‚ O. E. Jensen‚ P. K. Maini and H. M. Byrne

In Philosophical Transactions of the Royal Society A: Mathematical‚ Physical and Engineering Sciences. Vol. 368. No. 1930. Pages 5013–5028. November, 2010.

Details | BibTeX | DOI (10.1098/rsta.2010.0173)

A numerical guide to the solution of the bidomain equations of cardiac electrophysiology

P. Pathmanathan‚ M.O. Bernabeu‚ R. Bordas‚ J. Cooper‚ A. Garny‚ J. Pitt−Francis‚ J.P. Whiteley and D.J. Gavaghan

In Progress in Biophysics and Molecular Biology. Vol. 102. No. (2−3). Pages 136−155. 2010.

Details | BibTeX | DOI (10.1016/j.pbiomolbio.2010.05.006)